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Michael McIntosh

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TOP 3
Maryka Quik; Matthew Chin; Archana Mallela; J Michael McIntosh; Xiomara A Perez; Tanuja Bordia
Nicotine-mediated improvement in L-dopa-induced dyskinesias in MPTP-lesioned monkeys is dependent on dopamine nerve terminal function.
Heidi C O'Neill; Natalie E Patzlaff; J Michael McIntosh; Sheri McKinney; Bruce N Cohen; Carlos Fonck; Sharon R Grady; Duncan C Laverty; Henry A Lester; Jon M Lindstrom; Michael J Marks
Mice expressing the ADNFLE valine 287 leucine mutation of the Β2 nicotinic acetylcholine receptor subunit display increased sensitivity to acute nicotine administration and altered presynaptic nicotinic receptor function.
Layla Azam; J Michael McIntosh
Molecular basis for the differential sensitivity of rat and human α9α10 nAChRs to α-conotoxin RgIA.

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2013: Maryka Quik; Matthew Chin; Archana Mallela; J Michael McIntosh; Xiomara A Perez; Tanuja Bordia
Nicotine-mediated improvement in L-dopa-induced dyskinesias in MPTP-lesioned monkeys is dependent on dopamine nerve terminal function.
Neurobiology of disease 2013;50():30-41.
2013: Heidi C O'Neill; Natalie E Patzlaff; J Michael McIntosh; Sheri McKinney; Bruce N Cohen; Carlos Fonck; Sharon R Grady; Duncan C Laverty; Henry A Lester; Jon M Lindstrom; Michael J Marks
Mice expressing the ADNFLE valine 287 leucine mutation of the Β2 nicotinic acetylcholine receptor subunit display increased sensitivity to acute nicotine administration and altered presynaptic nicotinic receptor function.
Pharmacology, biochemistry, and behavior 2013;103(3):603-21.
2012: Layla Azam; J Michael McIntosh
Molecular basis for the differential sensitivity of rat and human α9α10 nAChRs to α-conotoxin RgIA.
Journal of neurochemistry 2012;122(6):1137-44.
2012: Maryka Quik; Maya Hrachova; Luping Z Huang; Archana Mallela; J Michael McIntosh; Keon Min Park; Sharon R Grady
Role for α6 nicotinic receptors in l-dopa-induced dyskinesias in parkinsonian mice.
Neuropharmacology 2012;63(3):450-9.
2012: Xiomara A Perez; Jason Ly; J Michael McIntosh; Maryka Quik
Long-term nicotine exposure depresses dopamine release in nonhuman primate nucleus accumbens.
The Journal of pharmacology and experimental therapeutics 2012;342(2):335-44.
2012: Tanuja Bordia; Matthew Chin; Maya Hrachova; J Michael McIntosh; Maryka Quik
Varenicline is a potent partial agonist at α6β2* nicotinic acetylcholine receptors in rat and monkey striatum.
The Journal of pharmacology and experimental therapeutics 2012;342(2):327-34.
2012: Elisha D W Mackey; Michael J Marks; J Michael McIntosh; Heidi C O'Neill; Natalie E Patzlaff; Charles R Wageman; Ying Wang; Staci E Engle; Sharon R Grady; Mi Ran Kim; Henry A Lester; Ryan M Drenan
α6* nicotinic acetylcholine receptor expression and function in a visual salience circuit.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2012;32(30):10226-37.
2012: Tanuja Bordia; J Michael McIntosh; Maryka Quik
Nicotine reduces antipsychotic-induced orofacial dyskinesia in rats.
The Journal of pharmacology and experimental therapeutics 2012;340(3):612-9.
2012: Arik J Hone; Melissa McIntyre; Erin L Meyer; J Michael McIntosh
Nicotinic acetylcholine receptors in dorsal root ganglion neurons include the α6β4* subtype.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2012;26(2):917-26.
2012: Alberto Pérez-Alvarez; Angel Tabernero; Sergio Alonso y Gregorio; Alicia Hernández-Vivanco; J Michael McIntosh; Almudena Albillos
Pharmacological characterization of native α7 nicotinic ACh receptors and their contribution to depolarization-elicited exocytosis in human chromaffin cells.
British journal of pharmacology 2012;165(4):908-21.
2011: Isabelle Catherina Roux; Eric Wersinger; Paul A Fuchs; J Michael McIntosh; Elisabeth Glowatzki
Onset of cholinergic efferent synaptic function in sensory hair cells of the rat cochlea.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2011;31(42):15092-101.
2011: Cheng Xiao; Ryan M Drenan; Elisha D W Mackey; J Michael McIntosh; Rahul Srinivasan; Henry A Lester
Characterizing functional α6β2 nicotinic acetylcholine receptors in vitro: mutant β2 subunits improve membrane expression, and fluorescent proteins reveal responsive cells.
Biochemical pharmacology 2011;82(8):852-61.
2010: Layla Azam; Uwe Maskos; Jean-Pierre Changeux; Cheryl Dowell; Sean Christensen; Mariella De Biasi; J Michael McIntosh
α-Conotoxin BuIA[T5A;P6O]: a novel ligand that discriminates between α6ß4 and α6ß2 nicotinic acetylcholine receptors and blocks nicotine-stimulated norepinephrine release.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2010;24(12):5113-23.
2010: Xiomara A Perez; Tanuja Bordia; J Michael McIntosh; Maryka Quik
α6ß2* and α4ß2* nicotinic receptors both regulate dopamine signaling with increased nigrostriatal damage: relevance to Parkinson's disease.
Molecular pharmacology 2010;78(5):971-80.
2010: Ryan M Drenan; Sharon R Grady; Andrew D Steele; Sheri McKinney; Natalie E Patzlaff; J Michael McIntosh; Michael J Marks; Julie M Miwa; Henry A Lester
Cholinergic modulation of locomotion and striatal dopamine release is mediated by alpha6alpha4* nicotinic acetylcholine receptors.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2010;30(29):9877-89.
2010: Sharon R Grady; Outi Salminen; J Michael McIntosh; Michael J Marks; Allan C Collins
Mouse striatal dopamine nerve terminals express alpha4alpha5beta2 and two stoichiometric forms of alpha4beta2*-nicotinic acetylcholine receptors.
Journal of molecular neuroscience : MN 2010;40(1-2):91-5.
2010: Maryka Quik; Carla Campos; Neeraja Parameswaran; J William Langston; J Michael McIntosh; Michael Yeluashvili
Chronic nicotine treatment increases nAChRs and microglial expression in monkey substantia nigra after nigrostriatal damage.
Journal of molecular neuroscience : MN 2010;40(1-2):105-13.
2010: Michael J Marks; Duncan S Laverty; Paul Whiteaker; Outi Salminen; Sharon R Grady; J Michael McIntosh; Allan C Collins
John Daly's compound, epibatidine, facilitates identification of nicotinic receptor subtypes.
Journal of molecular neuroscience : MN 2010;40(1-2):96-104.
2009: Arik J Hone; Paul Whiteaker; Sean Christensen; Yingxian Xiao; Erin L Meyer; J Michael McIntosh
A novel fluorescent alpha-conotoxin for the study of alpha7 nicotinic acetylcholine receptors.
Journal of neurochemistry 2009;111(1):80-9.
2009: J Michael McIntosh; Nathan Absalom; Mary Chebib; Ana Belen Elgoyhen; Michelle Vincler
Alpha9 nicotinic acetylcholine receptors and the treatment of pain.
Biochemical pharmacology 2009;78(7):693-702.
2009: Layla Azam; J Michael McIntosh
Alpha-conotoxins as pharmacological probes of nicotinic acetylcholine receptors.
Acta pharmacologica Sinica 2009;30(6):771-83.
2009: Xiomara A Perez; Kathryn T O'Leary; Neeraja Parameswaran; J Michael McIntosh; Maryka Quik
Prominent role of alpha3/alpha6beta2* nAChRs in regulating evoked dopamine release in primate putamen: effect of long-term nicotine treatment.
Molecular pharmacology 2009;75(4):938-46.
2008: Xiomara A Perez; Tanuja Bordia; J Michael McIntosh; Sharon R Grady; Maryka Quik
Long-term nicotine treatment differentially regulates striatal alpha6alpha4beta2* and alpha6(nonalpha4)beta2* nAChR expression and function.
Molecular pharmacology 2008;74(3):844-53.
2008: Erin L Meyer; Doju Yoshikami; J Michael McIntosh
The neuronal nicotinic acetylcholine receptors alpha 4* and alpha 6* differentially modulate dopamine release in mouse striatal slices.
Journal of neurochemistry 2008;105(5):1761-9.
2008: Layla Azam; Doju Yoshikami; J Michael McIntosh
Amino acid residues that confer high selectivity of the alpha6 nicotinic acetylcholine receptor subunit to alpha-conotoxin MII[S4A,E11A,L15A].
The Journal of biological chemistry 2008;283(17):11625-32.
2008: Michael Ellison; Zhi-Ping Feng; Anthony J Park; Xuecheng Zhang; Baldomero M Olivera; J Michael McIntosh; Raymond S Norton
Alpha-RgIA, a novel conotoxin that blocks the alpha9alpha10 nAChR: structure and identification of key receptor-binding residues.
Journal of molecular biology 2008;377(4):1216-27.
2008: Baldomero M Olivera; Maryka Quik; Michelle Vincler; J Michael McIntosh
Subtype-selective conopeptides targeted to nicotinic receptors: Concerted discovery and biomedical applications.
Channels (Austin, Tex.) 2008;2(2):143-52.
2007: Sharon R Grady; Outi Salminen; Duncan C Laverty; Paul Whiteaker; J Michael McIntosh; Allan C Collins; Michael J Marks
The subtypes of nicotinic acetylcholine receptors on dopaminergic terminals of mouse striatum.
Biochemical pharmacology 2007;74(8):1235-46.
2007: Yaroslav Teper; Douglas Whyte; Elizabeth Cahir; Henry A Lester; Sharon R Grady; Michael J Marks; Bruce N Cohen; Carlos Fonck; Tristan McClure-Begley; J Michael McIntosh; Cesar Labarca; Andrew Lawrence; Feng Chen; Ilse Gantois; Philip J Davies; Steven Petrou; Mark Murphy; John Waddington; Malcolm K Horne; Samuel F Berkovic; John Drago
Nicotine-induced dystonic arousal complex in a mouse line harboring a human autosomal-dominant nocturnal frontal lobe epilepsy mutation.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2007;27(38):10128-42.
2007: Tanuja Bordia; Sharon R Grady; J Michael McIntosh; Maryka Quik
Nigrostriatal damage preferentially decreases a subpopulation of alpha6beta2* nAChRs in mouse, monkey, and Parkinson's disease striatum.
Molecular pharmacology 2007;72(1):52-61.
2007: Paul Whiteaker; Sean Christensen; Doju Yoshikami; Cheryl Dowell; Maren Watkins; Jozsef Gulyas; Jean Rivier; Baldomero M Olivera; J Michael McIntosh
Discovery, synthesis, and structure activity of a highly selective alpha7 nicotinic acetylcholine receptor antagonist.
Biochemistry 2007;46(22):6628-38.
2007: Outi Salminen; Jennifer A Drapeau; J Michael McIntosh; Allan C Collins; Michael J Marks; Sharon R Grady
Pharmacology of alpha-conotoxin MII-sensitive subtypes of nicotinic acetylcholine receptors isolated by breeding of null mutant mice.
Molecular pharmacology 2007;71(6):1563-71.
2007: Mirium Khwaja; Alison L McCormack; J Michael McIntosh; Donato A Di Monte; Maryka Quik
Nicotine partially protects against paraquat-induced nigrostriatal damage in mice; link to alpha6beta2* nAChRs.
Journal of neurochemistry 2007;100(1):180-90.
2006: Vijay A Vishwanath; J Michael McIntosh
Synthesis of fluorescent analogs of alpha-conotoxin MII.
Bioconjugate chemistry 2006;17(6):1612-7.
2006: Tanuja Bordia; Neeraja Parameswaran; Hong Fan; J William Langston; J Michael McIntosh; Maryka Quik
Partial recovery of striatal nicotinic receptors in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-lesioned monkeys with chronic oral nicotine.
The Journal of pharmacology and experimental therapeutics 2006;319(1):285-92.
2006: David L Shiembob; Ryan L Roberts; Charles W Luetje; J Michael McIntosh
Determinants of alpha-conotoxin BuIA selectivity on the nicotinic acetylcholine receptor beta subunit.
Biochemistry 2006;45(37):11200-7.
2006: Layla Azam; J Michael McIntosh
Characterization of nicotinic acetylcholine receptors that modulate nicotine-evoked [3H]norepinephrine release from mouse hippocampal synaptosomes.
Molecular pharmacology 2006;70(3):967-76.
2006: Sarah E McCallum; Neeraja Parameswaran; Tanuja Bordia; Hong Fan; J Michael McIntosh; Maryka Quik
Differential regulation of mesolimbic alpha 3/alpha 6 beta 2 and alpha 4 beta 2 nicotinic acetylcholine receptor sites and function after long-term oral nicotine to monkeys.
The Journal of pharmacology and experimental therapeutics 2006;318(1):381-8.
2006: Michael Ellison; Christian Haberlandt; María E Gomez-Casati; Maren Watkins; Ana Belen Elgoyhen; J Michael McIntosh; Baldomero M Olivera
Alpha-RgIA: a novel conotoxin that specifically and potently blocks the alpha9alpha10 nAChR.
Biochemistry 2006;45(5):1511-7.
2006: Sarah E McCallum; Neeraja Parameswaran; Xiomara A Perez; S Bao; J Michael McIntosh; Sharon R Grady; Maryka Quik
Compensation in pre-synaptic dopaminergic function following nigrostriatal damage in primates.
Journal of neurochemistry 2006;96(4):960-72.
2006: Sarah E McCallum; Neeraja Parameswaran; Tanuja Bordia; Hong Fan; Rachel F Tyndale; J William Langston; J Michael McIntosh; Maryka Quik
Increases in alpha4* but not alpha3*/alpha6* nicotinic receptor sites and function in the primate striatum following chronic oral nicotine treatment.
Journal of neurochemistry 2006;96(4):1028-41.
2006: Maryka Quik; J Michael McIntosh
Striatal alpha6* nicotinic acetylcholine receptors: potential targets for Parkinson's disease therapy.
The Journal of pharmacology and experimental therapeutics 2006;316(2):481-9.
2005: Sarah E McCallum; Neeraja Parameswaran; Tanuja Bordia; J Michael McIntosh; Sharon R Grady; Maryka Quik
Decrease in alpha3*/alpha6* nicotinic receptors but not nicotine-evoked dopamine release in monkey brain after nigrostriatal damage.
Molecular pharmacology 2005;68(3):737-46.
2005: J Michael McIntosh; Paola V Plazas; Maren Watkins; María E Gomez-Casati; Baldomero M Olivera; Ana Belen Elgoyhen
A novel alpha-conotoxin, PeIA, cloned from Conus pergrandis, discriminates between rat alpha9alpha10 and alpha7 nicotinic cholinergic receptors.
The Journal of biological chemistry 2005;280(34):30107-12.
2005: Gloria P Corpuz; Richard B Jacobsen; Elsie C Jimenez; Maren Watkins; Craig Walker; Clark Colledge; James E Garrett; Owen McDougal; Wenqin Li; William R Gray; David R Hillyard; Jean Rivier; J Michael McIntosh; Lourdes J Cruz; Baldomero M Olivera
Definition of the M-conotoxin superfamily: characterization of novel peptides from molluscivorous Conus venoms.
Biochemistry 2005;44(22):8176-86.
2005: Albert Lai; Neeraja Parameswaran; Mirium Khwaja; Paul Whiteaker; Jon M Lindstrom; Hong Fan; J Michael McIntosh; Sharon R Grady; Maryka Quik
Long-term nicotine treatment decreases striatal alpha 6* nicotinic acetylcholine receptor sites and function in mice.
Molecular pharmacology 2005;67(5):1639-47.
2005: Outi Salminen; Paul Whiteaker; Sharon R Grady; Allan C Collins; J Michael McIntosh; Michael J Marks
The subunit composition and pharmacology of alpha-Conotoxin MII-binding nicotinic acetylcholine receptors studied by a novel membrane-binding assay.
Neuropharmacology 2005;48(5):696-705.
2005: Layla Azam; Cheryl Dowell; Maren Watkins; Jerry A Stitzel; Baldomero M Olivera; J Michael McIntosh
Alpha-conotoxin BuIA, a novel peptide from Conus bullatus, distinguishes among neuronal nicotinic acetylcholine receptors.
The Journal of biological chemistry 2005;280(1):80-7.
2005: Maryka Quik; Silvia Vailati; Tanuja Bordia; Jennifer M Kulak; Hong Fan; J Michael McIntosh; Francesco Clementi; Cecilia Gotti
Subunit composition of nicotinic receptors in monkey striatum: effect of treatments with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine or L-DOPA.
Molecular pharmacology 2005;67(1):32-41.
2005: Layla Azam; J Michael McIntosh
Effect of novel alpha-conotoxins on nicotine-stimulated [3H]dopamine release from rat striatal synaptosomes.
The Journal of pharmacology and experimental therapeutics 2005;312(1):231-7.
2004: Michael Ellison; Fan Gao; Hai-Long Wang; Steven M Sine; J Michael McIntosh; Baldomero M Olivera
Alpha-conotoxins ImI and ImII target distinct regions of the human alpha7 nicotinic acetylcholine receptor and distinguish human nicotinic receptor subtypes.
Biochemistry 2004;43(51):16019-26.
2004: Siqin Luo; J Michael McIntosh
Iodo-alpha-conotoxin MI selectively binds the alpha/delta subunit interface of muscle nicotinic acetylcholine receptors.
Biochemistry 2004;43(21):6656-62.
2004: Outi Salminen; Karen L Murphy; J Michael McIntosh; John Drago; Michael J Marks; Allan C Collins; Sharon R Grady
Subunit composition and pharmacology of two classes of striatal presynaptic nicotinic acetylcholine receptors mediating dopamine release in mice.
Molecular pharmacology 2004;65(6):1526-35.
2004: Ameurfina D Santos; J Michael McIntosh; David R Hillyard; Lourdes J Cruz; Baldomero M Olivera
The A-superfamily of conotoxins: structural and functional divergence.
The Journal of biological chemistry 2004;279(17):17596-606.
2004: J Michael McIntosh; Layla Azam; Sarah Staheli; Cheryl Dowell; Jon M Lindstrom; Alexander Kuryatov; James E Garrett; Michael J Marks; Paul Whiteaker
Analogs of alpha-conotoxin MII are selective for alpha6-containing nicotinic acetylcholine receptors.
Molecular pharmacology 2004;65(4):944-52.
2004: Drew Everhart; George Cartier; Arun Malhotra; Aldrin Gomes; J Michael McIntosh; Charles W Luetje
Determinants of potency on alpha-conotoxin MII, a peptide antagonist of neuronal nicotinic receptors.
Biochemistry 2004;43(10):2732-7.
2004: Maryka Quik; Tanuja Bordia; L Forno; J Michael McIntosh
Loss of alpha-conotoxinMII- and A85380-sensitive nicotinic receptors in Parkinson's disease striatum.
Journal of neurochemistry 2004;88(3):668-79.
2004: A Lai; Jocelyn D Sum; H Fan; J Michael McIntosh; Maryka Quik
Selective recovery of striatal 125I-alpha-conotoxinmii nicotinic receptors after nigrostriatal damage in monkeys.
Neuroscience 2004;127(2):399-408.
2003: Changhai Cui; TK Booker; Roberta S Allen; Sharon R Grady; Paul Whiteaker; Michael J Marks; Outi Salminen; Theresa Tritto; Christopher M Butt; W R Allen; Jerry A Stitzel; J Michael McIntosh; Jim Boulter; Allan C Collins; Stephen F Heinemann
The beta3 nicotinic receptor subunit: a component of alpha-conotoxin MII-binding nicotinic acetylcholine receptors that modulate dopamine release and related behaviors.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2003;23(35):11045-53.
2003: Seung-Wook Chi; Kyu-Hwan Park; Jae-Eun Suk; Baldomero M Olivera; J Michael McIntosh; Kyou-Hoon Han
Solution conformation of alphaA-conotoxin EIVA, a potent neuromuscular nicotinic acetylcholine receptor antagonist from Conus ermineus.
The Journal of biological chemistry 2003;278(43):42208-13.
2003: Cheryl Dowell; Baldomero M Olivera; James E Garrett; Sarah T Staheli; Maren Watkins; Alexander Kuryatov; Doju Yoshikami; Jon M Lindstrom; J Michael McIntosh
Alpha-conotoxin PIA is selective for alpha6 subunit-containing nicotinic acetylcholine receptors.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2003;23(24):8445-52.
2003: Maryka Quik; Tanuja Bordia; Michaella Okihara; Hong Fan; Michael J Marks; J Michael McIntosh; Paul Whiteaker
L-DOPA treatment modulates nicotinic receptors in monkey striatum.
Molecular pharmacology 2003;64(3):619-28.
2003: Drew Everhart; Edward Reiller; Armen Mirzoian; J Michael McIntosh; Arun Malhotra; Charles W Luetje
Identification of residues that confer alpha-conotoxin-PnIA sensitivity on the alpha 3 subunit of neuronal nicotinic acetylcholine receptors.
The Journal of pharmacology and experimental therapeutics 2003;306(2):664-70.
2003: Maryka Quik; Jocelyn D Sum; Paul Whiteaker; Sarah E McCallum; Michael J Marks; John L Musachio; J Michael McIntosh; Allan C Collins; Sharon R Grady
Differential declines in striatal nicotinic receptor subtype function after nigrostriatal damage in mice.
Molecular pharmacology 2003;63(5):1169-79.
2003: Michael Ellison; J Michael McIntosh; Baldomero M Olivera
Alpha-conotoxins ImI and ImII. Similar alpha 7 nicotinic receptor antagonists act at different sites.
The Journal of biological chemistry 2003;278(2):757-64.
2002: Jennifer M Kulak; John L Musachio; J Michael McIntosh; Maryka Quik
Declines in different beta2* nicotinic receptor populations in monkey striatum after nigrostriatal damage.
The Journal of pharmacology and experimental therapeutics 2002;303(2):633-9.
2002: J Michael McIntosh; Cheryl Dowell; Maren Watkins; James E Garrett; Doju Yoshikami; Baldomero M Olivera
Alpha-conotoxin GIC from Conus geographus, a novel peptide antagonist of nicotinic acetylcholine receptors.
The Journal of biological chemistry 2002;277(37):33610-5.
2002: Michael J Marks; Paul Whiteaker; Sharon R Grady; Marina R Picciotto; J Michael McIntosh; Allan C Collins
Characterization of [(125) I]epibatidine binding and nicotinic agonist-mediated (86) Rb(+) efflux in interpeduncular nucleus and inferior colliculus of beta2 null mutant mice.
Journal of neurochemistry 2002;81(5):1102-15.
2002: Sharon R Grady; Karen L Murphy; Jian Cao; Michael J Marks; J Michael McIntosh; Allan C Collins
Characterization of nicotinic agonist-induced [(3)H]dopamine release from synaptosomes prepared from four mouse brain regions.
The Journal of pharmacology and experimental therapeutics 2002;301(2):651-60.
2002: Jennifer M Kulak; Jocelyn D Sum; John L Musachio; J Michael McIntosh; Maryka Quik
5-Iodo-A-85380 binds to alpha-conotoxin MII-sensitive nicotinic acetylcholine receptors (nAChRs) as well as alpha4beta2* subtypes.
Journal of neurochemistry 2002;81(2):403-6.
2002: Paul Whiteaker; Cyrus G Peterson; Wei Xu; J Michael McIntosh; Richard Paylor; Arthur L Beaudet; Allan C Collins; Michael J Marks
Involvement of the alpha3 subunit in central nicotinic binding populations.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2002;22(7):2522-9.
2002: Maryka Quik; Y Polonskaya; J Michael McIntosh; Jennifer M Kulak
Differential nicotinic receptor expression in monkey basal ganglia: effects of nigrostriatal damage.
Neuroscience 2002;112(3):619-30.
2002: Jennifer M Kulak; J Michael McIntosh; Maryka Quik
Loss of nicotinic receptors in monkey striatum after 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine treatment is due to a decline in alpha-conotoxin MII sites.
Molecular pharmacology 2002;61(1):230-8.
2001: KH Park; J E Suk; Richard B Jacobsen; William R Gray; J Michael McIntosh; KH Han
Solution conformation of alpha-conotoxin EI, a neuromuscular toxin specific for the alpha 1/delta subunit interface of torpedo nicotinic acetylcholine receptor.
The Journal of biological chemistry 2001;276(52):49028-33.
2001: J Michael McIntosh; R M Jones
Cone venom--from accidental stings to deliberate injection.
Toxicon : official journal of the International Society on Toxinology 2001;39(10):1447-51.
2001: Maryka Quik; Y Polonskaya; Jennifer M Kulak; J Michael McIntosh
Vulnerability of 125I-alpha-conotoxin MII binding sites to nigrostriatal damage in monkey.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2001;21(15):5494-500.
2001: JM Kulak; J Michael McIntosh; Doju Yoshikami; Baldomero M Olivera
Nicotine-evoked transmitter release from synaptosomes: functional association of specific presynaptic acetylcholine receptors and voltage-gated calcium channels.
Journal of neurochemistry 2001;77(6):1581-9.
2001: B Barabino; Silvia Vailati; Milena Moretti; J Michael McIntosh; Renato Longhi; Francesco Clementi; Cecilia Gotti
An alpha4beta4 nicotinic receptor subtype is present in chick retina: identification, characterization and pharmacological comparison with the transfected alpha4beta4 and alpha6beta4 subtypes.
Molecular pharmacology 2001;59(6):1410-7.
2001: Sharon R Grady; N M Meinerz; J Cao; A M Reynolds; Marina R Picciotto; Jean-Pierre Changeux; J Michael McIntosh; Michael J Marks; Allan C Collins
Nicotinic agonists stimulate acetylcholine release from mouse interpeduncular nucleus: a function mediated by a different nAChR than dopamine release from striatum.
Journal of neurochemistry 2001;76(1):258-68.
2000: J Michael McIntosh; G O Corpuz; Richard T Layer; James E Garrett; John D Wagstaff; Grzegorz Bulaj; A Vyazovkina; Doju Yoshikami; Lourdes J Cruz; Baldomero M Olivera
Isolation and characterization of a novel conus peptide with apparent antinociceptive activity.
The Journal of biological chemistry 2000;275(42):32391-7.
2000: Paul Whiteaker; M Jimenez; J Michael McIntosh; Allan C Collins; Michael J Marks
Identification of a novel nicotinic binding site in mouse brain using [(125)I]-epibatidine.
British journal of pharmacology 2000;131(4):729-39.
2000: Steve Bibevski; Y Zhou; J Michael McIntosh; Richard E Zigmond; Mark E Dunlap
Functional nicotinic acetylcholine receptors that mediate ganglionic transmission in cardiac parasympathetic neurons.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2000;20(13):5076-82.
2000: Paul Whiteaker; J Michael McIntosh; S Luo; Allan C Collins; Michael J Marks
125I-alpha-conotoxin MII identifies a novel nicotinic acetylcholine receptor population in mouse brain.
Molecular pharmacology 2000;57(5):913-25.
2000: J Michael McIntosh; S Gardner; Siqin Luo; James E Garrett; Doju Yoshikami
Conus peptides: novel probes for nicotinic acetylcholine receptor structure and function.
European journal of pharmacology 2000;393(1-3):205-8.
2000: J H Cho; K Hun Mok; B M Olivera; J Michael McIntosh; KH Park; KH Han
Nuclear magnetic resonance solution conformation of alpha-conotoxin AuIB, an alpha(3)beta(4) subtype-selective neuronal nicotinic acetylcholine receptor antagonist.
The Journal of biological chemistry 2000;275(12):8680-5.
1999: Siqin Luo; T A Nguyen; George Cartier; Baldomero M Olivera; Doju Yoshikami; J Michael McIntosh
Single-residue alteration in alpha-conotoxin PnIA switches its nAChR subtype selectivity.
Biochemistry 1999;38(44):14542-8.
1999: Richard B Jacobsen; Richard DeLaCruz; J H Grose; J Michael McIntosh; Doju Yoshikami; Baldomero M Olivera
Critical residues influence the affinity and selectivity of alpha-conotoxin MI for nicotinic acetylcholine receptors.
Biochemistry 1999;38(40):13310-5.
1999: J Michael McIntosh; Ameurfina D Santos; Baldomero M Olivera
Conus peptides targeted to specific nicotinic acetylcholine receptor subtypes.
Annual review of biochemistry 1999;68():59-88.
1999: J Michael McIntosh; Baldomero M Olivera; Lourdes J Cruz
Conus peptides as probes for ion channels.
Methods in enzymology 1999;294():605-24.
1998: Siqin Luo; JM Kulak; George Cartier; Richard B Jacobsen; Doju Yoshikami; Baldomero M Olivera; J Michael McIntosh
alpha-conotoxin AuIB selectively blocks alpha3 beta4 nicotinic acetylcholine receptors and nicotine-evoked norepinephrine release.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1998;18(21):8571-9.
1997: KJ Shon; Steven C Koerber; Jean E Rivier; Baldomero M Olivera; J Michael McIntosh
Three-dimensional solution structure of alpha-conotoxin MII, an alpha3beta2 neuronal nicotinic acetylcholine receptor-targeted ligand.
Biochemistry 1997;36(50):15693-700.
1997: Richard B Jacobsen; Doju Yoshikami; Michael Ellison; J Martinez; William R Gray; George Cartier; KJ Shon; DR Groebe; SN Abramson; Baldomero M Olivera; J Michael McIntosh
Differential targeting of nicotinic acetylcholine receptors by novel alphaA-conotoxins.
The Journal of biological chemistry 1997;272(36):22531-7.
1997: JM Kulak; T A Nguyen; Baldomero M Olivera; J Michael McIntosh
Alpha-conotoxin MII blocks nicotine-stimulated dopamine release in rat striatal synaptosomes.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1997;17(14):5263-70.
1997: Sohail F Tavazoie; M F Tavazoie; J Michael McIntosh; Baldomero M Olivera; Doju Yoshikami
Differential block of nicotinic synapses on B versus C neurones in sympathetic ganglia of frog by alpha-conotoxins MII and ImI.
British journal of pharmacology 1997;120(6):995-1000.
1997: A Grey Craig; Elsie C Jimenez; John Dykert; D B Nielsen; Jozsef Gulyas; Fe C Abogadie; J Porter; Jean E Rivier; Lourdes J Cruz; Baldomero M Olivera; J Michael McIntosh
A novel post-translational modification involving bromination of tryptophan. Identification of the residue, L-6-bromotryptophan, in peptides from Conus imperialis and Conus radiatus venom.
The Journal of biological chemistry 1997;272(8):4689-98.
1997: SC Harvey; J Michael McIntosh; George Cartier; Floyd N Maddox; Charles W Luetje
Determinants of specificity for alpha-conotoxin MII on alpha3beta2 neuronal nicotinic receptors.
Molecular pharmacology 1997;51(2):336-42.
1996: Heinrich Terlau; Martin Stocker; KJ Shon; J Michael McIntosh; Baldomero M Olivera
MicroO-conotoxin MrVIA inhibits mammalian sodium channels, but not through site I.
Journal of neurophysiology 1996;76(3):1423-9.
1996: George Cartier; Doju Yoshikami; William R Gray; Siqin Luo; Baldomero M Olivera; J Michael McIntosh
A new alpha-conotoxin which targets alpha3beta2 nicotinic acetylcholine receptors.
The Journal of biological chemistry 1996;271(13):7522-8.
1995: J S Martinez; Baldomero M Olivera; William R Gray; A Grey Craig; D R Groebe; S N Abramson; J Michael McIntosh
alpha-Conotoxin EI, a new nicotinic acetylcholine receptor antagonist with novel selectivity.
Biochemistry 1995;34(44):14519-26.
1995: J Michael McIntosh; A Hasson; Micha E Spira; William R Gray; W Li; M Marsh; David R Hillyard; Baldomero M Olivera
A new family of conotoxins that blocks voltage-gated sodium channels.
The Journal of biological chemistry 1995;270(28):16796-802.
1995: J Michael McIntosh; F Ghomashchi; M H Gelb; David J Dooley; SJ Stoehr; A B Giordani; S R Naisbitt; Baldomero M Olivera
Conodipine-M, a novel phospholipase A2 isolated from the venom of the marine snail Conus magus.
The Journal of biological chemistry 1995;270(8):3518-26.
1994: D B Nielsen; John Dykert; Jean E Rivier; J Michael McIntosh
Isolation of Lys-conopressin-G from the venom of the worm-hunting snail, Conus imperialis.
Toxicon : official journal of the International Society on Toxinology 1994;32(7):845-8.
1994: J Michael McIntosh; Doju Yoshikami; E Mahe; D B Nielsen; Jean E Rivier; William R Gray; Baldomero M Olivera
A nicotinic acetylcholine receptor ligand of unique specificity, alpha-conotoxin ImI.
The Journal of biological chemistry 1994;269(24):16733-9.
1994: Francis M Filloux; A Schapper; S R Naisbitt; Baldomero M Olivera; J Michael McIntosh
Complex patterns of [125I]omega-conotoxin GVIA binding site expression during postnatal rat brain development.
Brain research. Developmental brain research 1994;78(1):131-6.
1993: J Michael McIntosh; T A Foderaro; W Li; Chris M Ireland; Baldomero M Olivera
Presence of serotonin in the venom of Conus imperialis.
Toxicon : official journal of the International Society on Toxinology 1993;31(12):1561-6.
1993: B C Albensi; K T Ryujin; J Michael McIntosh; S R Naisbitt; Baldomero M Olivera; F Fillous
Localization of [125I]omega-conotoxin GVIA binding in human hippocampus and cerebellum.
Neuroreport 1993;4(12):1331-4.
1992: J Michael McIntosh; Michael E Adams; Baldomero M Olivera; Francis M Filloux
Autoradiographic localization of the binding of calcium channel antagonist, [125I]omega-agatoxin IIIA, in rat brain.
Brain research 1992;594(1):109-14.
1992: David R Hillyard; V D Monje; I M Mintz; Bruce P Bean; L Nadasdi; J Ramachandran; GP Miljanich; A Azimi-Zoonooz; J Michael McIntosh; Lourdes J Cruz
A new Conus peptide ligand for mammalian presynaptic Ca2+ channels.
Neuron 1992;9(1):69-77.
1987: Baldomero M Olivera; Lourdes J Cruz; V de Santos; G W LeCheminant; D Griffin; R Zeikus; J Michael McIntosh; R Galyean; J Varga; William R Gray
Neuronal calcium channel antagonists. Discrimination between calcium channel subtypes using omega-conotoxin from Conus magus venom.
Biochemistry 1987;26(8):2086-90.
1987: Jean Rivier; R Galyean; William R Gray; A Azimi-Zonooz; J Michael McIntosh; Lourdes J Cruz; Baldomero M Olivera
Neuronal calcium channel inhibitors. Synthesis of omega-conotoxin GVIA and effects on 45Ca uptake by synaptosomes.
The Journal of biological chemistry 1987;262(3):1194-8.
1985: Baldomero M Olivera; William R Gray; R Zeikus; J Michael McIntosh; J Varga; J Rivier; V de Santos; Lourdes J Cruz
Peptide neurotoxins from fish-hunting cone snails.
Science (New York, N.Y.) 1985;230(4732):1338-43.
1985: B M Olivera; J Michael McIntosh; C Clark; D Middlemas; William R Gray; Lourdes J Cruz
A sleep-inducing peptide from Conus geographus venom.
Toxicon : official journal of the International Society on Toxinology 1985;23(2):277-82.
1984: J Michael McIntosh; B M Olivera; Lourdes J Cruz; William R Gray
Gamma-carboxyglutamate in a neuroactive toxin.
The Journal of biological chemistry 1984;259(23):14343-6.
1984: B M Olivera; J Michael McIntosh; Lourdes J Cruz; F A Luque; William R Gray
Purification and sequence of a presynaptic peptide toxin from Conus geographus venom.
Biochemistry 1984;23(22):5087-90.