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Gordon McKay

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Jiang Ping Luo; Gordon McKay; Kamal K Midha; Sarvesh C Vashishtha; Edward M Hawes; Jim Fang
In vitro identification of the human cytochrome p450 enzymes involved in the oxidative metabolism of loxapine.
Kamal K Midha; Maureen J Rawson; Gordon McKay; John W Hubbard
Exposure measures applied to the bioequivalence of two sustained release formulations of bupropion.
Karen E Mosier; Jiuxue Song; Gordon McKay; John W Hubbard; Jim Fang
Determination of clozapine, and its metabolites, N-desmethylclozapine and clozapine N-oxide in dog plasma using high-performance liquid chromatography.

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2011: Jiang Ping Luo; Gordon McKay; Kamal K Midha; Sarvesh C Vashishtha; Edward M Hawes; Jim Fang
In vitro identification of the human cytochrome p450 enzymes involved in the oxidative metabolism of loxapine.
Biopharmaceutics & drug disposition 2011;32(7):398-407.
2005: Kamal K Midha; Maureen J Rawson; Gordon McKay; John W Hubbard
Exposure measures applied to the bioequivalence of two sustained release formulations of bupropion.
International journal of clinical pharmacology and therapeutics 2005;43(5):244-54.
2003: Karen E Mosier; Jiuxue Song; Gordon McKay; John W Hubbard; Jim Fang
Determination of clozapine, and its metabolites, N-desmethylclozapine and clozapine N-oxide in dog plasma using high-performance liquid chromatography.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2003;783(2):377-82.
2002: J-H Yan; John W Hubbard; Gordon McKay; E D Korchinski; Kamal K Midha
Absolute bioavailability and stereoselective pharmacokinetics of doxepin.
Xenobiotica; the fate of foreign compounds in biological systems 2002;32(7):615-23.
2001: J Fang; Gordon McKay; J Song; A Remillrd; X Li; Kamal K Midha
In vitro characterization of the metabolism of haloperidol using recombinant cytochrome p450 enzymes and human liver microsomes.
Drug metabolism and disposition: the biological fate of chemicals 2001;29(12):1638-43.
2001: Sarvesh C Vashishtha; Edward M Hawes; Gordon McKay; Denis J McCann
Quaternary ammonium-linked glucuronidation of 1-substituted imidazoles: studies of human UDP-glucuronosyltransferases involved and substrate specificities.
Drug metabolism and disposition: the biological fate of chemicals 2001;29(10):1290-5.
2001: Kamal K Midha; Gordon McKay; Maureen J Rawson; E D Korchinski; John W Hubbard
Effects of food on the pharmacokinetics of methylphenidate.
Pharmaceutical research 2001;18(8):1185-9.
2000: J Fang; Gordon McKay; John W Hubbard; Edward M Hawes; Kamal K Midha
Dose staggering as a strategy to reduce drug--drug interactions due to reversible enzyme inhibition between orally administered drugs with high first pass effect: a computer simulation study.
Biopharmaceutics & drug disposition 2000;21(7):249-59.
2000: Sarvesh C Vashishtha; Edward M Hawes; Gordon McKay; Denis J McCann
Synthesis and identification of the quaternary ammonium-linked glucuronide of 1-phenylimidazole in human liver microsomes and investigation of the human UDP-glucuronosyltransferases involved.
Drug metabolism and disposition: the biological fate of chemicals 2000;28(9):1009-13.
2000: I Kowalczyk; Edward M Hawes; Gordon McKay
Stability and enzymatic hydrolysis of quaternary ammonium-linked glucuronide metabolites of drugs with an aliphatic tertiary amine-implications for analysis.
Journal of pharmaceutical and biomedical analysis 2000;22(5):803-11.
1999: Kamal K Midha; John W Hubbard; Gordon McKay; Maureen J Rawson; D Hsia
The role of metabolites in a bioequivalence study II: amoxapine, 7-hydroxyamoxapine, and 8-hydroxyamoxapine.
International journal of clinical pharmacology and therapeutics 1999;37(9):428-38.
1999: John W Hubbard; S Hadad; JP Luo; Gordon McKay; Kamal K Midha
Pharmacokinetics of fluphenazine, a highly lipophilic drug, estimated from a pulse dose of a stable isotopomer in dogs at steady state.
Journal of pharmaceutical sciences 1999;88(9):918-21.
1999: M Tugnait; Edward M Hawes; Gordon McKay; M Eichelbaum; Kamal K Midha
Characterization of the human hepatic cytochromes P450 involved in the in vitro oxidation of clozapine.
Chemico-biological interactions 1999;118(2):171-89.
1998: Kamal K Midha; Gordon McKay; Maureen J Rawson; John W Hubbard
The impact of stereoisomerism in bioequivalence studies.
Journal of pharmaceutical sciences 1998;87(7):797-802.
1998: W Tan; Q Li; Gordon McKay; Hugh A Semple
Identification and determination of phase I metabolites of propafenone in rat liver perfusate.
Journal of pharmaceutical and biomedical analysis 1998;16(6):991-1003.
1997: J H Yan; John W Hubbard; Gordon McKay; Kamal K Midha
Stereoselective in vivo and in vitro studies on the metabolism of doxepin and N-desmethyldoxepin.
Xenobiotica; the fate of foreign compounds in biological systems 1997;27(12):1245-57.
1997: M Tugnait; Edward M Hawes; Gordon McKay; Allan E Rettie; Robert L Haining; Kamal K Midha
N-oxygenation of clozapine by flavin-containing monooxygenase.
Drug metabolism and disposition: the biological fate of chemicals 1997;25(4):524-7.
1997: J Yan; John W Hubbard; Gordon McKay; Kamal K Midha
Stereoselective and simultaneous measurement of cis- and trans-isomers of doxepin and N-desmethyldoxepin in plasma or urine by high-performance liquid chromatography.
Journal of chromatography. B, Biomedical sciences and applications 1997;691(1):131-8.
1996: G O Zhang; Gordon McKay; John W Hubbard; Kamal K Midha
Application of electrospray mass spectrometry in the identification of intact glucuronide and suplate conjugates of clozapine in rat.
Xenobiotica; the fate of foreign compounds in biological systems 1996;26(5):541-50.
1996: Rossen Koytchev; Rudolf-Giesbert Alken; Gordon McKay; T Katzarov
Absolute bioavailability of oral immediate and slow release fluphenazine in healthy volunteers.
European journal of clinical pharmacology 1996;51(2):183-7.
1995: S Hadad; John W Hubbard; Gordon McKay; Edward M Hawes; S Shrikhande; Kamal K Midha
Evidence for the lack of a human metabolic isotope effect of a deuterium analog of fluphenazine.
Pharmaceutical research 1995;12(9):1388-90.
1995: H He; Gordon McKay; Kamal K Midha
Phase I and II metabolites of benztropine in rat urine and bile.
Xenobiotica; the fate of foreign compounds in biological systems 1995;25(8):857-72.
1995: H He; Gordon McKay; B Wirshing; Kamal K Midha
Development and application of a specific and sensitive radioimmunoassay for trihexyphenidyl to a pharmacokinetic study in humans.
Journal of pharmaceutical sciences 1995;84(5):561-7.
1995: H Luo; Edward M Hawes; Gordon McKay; E D Korchinski; Kamal K Midha
N(+)-glucuronidation of aliphatic tertiary amines in human: antidepressant versus antipsychotic drugs.
Xenobiotica; the fate of foreign compounds in biological systems 1995;25(3):291-301.
1994: H Luo; Gordon McKay; Kamal K Midha
Identification of clozapine N(+)-glucuronide in the urine of patients treated with clozapine using electrospray mass spectrometry.
Biological mass spectrometry 1994;23(3):147-8.
1993: John W Hubbard; Kamal K Midha; Edward M Hawes; Gordon McKay; Stephen R Marder; Manickam Aravagiri; E D Korchinski
Metabolism of phenothiazine and butyrophenone antipsychotic drugs. A review of some recent research findings and clinical implications.
The British journal of psychiatry. Supplement 1993;(22):19-24.
1993: G Lin; Edward M Hawes; Gordon McKay; E D Korchinski; Kamal K Midha
Metabolism of piperidine-type phenothiazine antipsychotic agents. IV. Thioridazine in dog, man and rat.
Xenobiotica; the fate of foreign compounds in biological systems 1993;23(10):1059-74.
1993: H He; Gordon McKay; Kamal K Midha
Development of a sensitive and specific radioimmunoassay for benztropine.
Journal of pharmaceutical sciences 1993;82(10):1027-32.
1993: Kamal K Midha; Stephen R Marder; T J Jaworski; Gordon McKay; John W Hubbard; Edward M Hawes; T Van Putten; William C Wirshing; Manickam Aravagiri
Clinical perspectives of some neuroleptics through development and application of their assays.
Therapeutic drug monitoring 1993;15(3):179-89.
1993: Kamal K Midha; John W Hubbard; Gordon McKay; Edward M Hawes; D Hsia
The role of metabolites in a bioequivalence study 1: loxapine, 7-hydroxyloxapine and 8-hydroxyloxapine.
International journal of clinical pharmacology, therapy, and toxicology 1993;31(4):177-83.
1993: T J Jaworski; M S Sardessai; Manickam Aravagiri; G Lin; Y Y Shi; Edward M Hawes; John W Hubbard; Gordon McKay; Kamal K Midha
Synthesis of the N-oxides of phenothiazine antipsychotic agents.
Journal of pharmaceutical sciences 1993;82(3):330-3.
1993: Kamal K Midha; E D Ormsby; John W Hubbard; Gordon McKay; Edward M Hawes; L Gavalas; I J McGilveray
Logarithmic transformation in bioequivalence: application with two formulations of perphenazine.
Journal of pharmaceutical sciences 1993;82(2):138-44.
1993: G Lin; Edward M Hawes; Gordon McKay; E D Korchinski; Kamal K Midha
The metabolism of piperidine-type phenothiazine antipsychotic agents. III. Mesoridazine in dog, human and rat.
Xenobiotica; the fate of foreign compounds in biological systems 1993;23(1):37-52.
1993: G Lin; Edward M Hawes; Gordon McKay; S F Cooper; E D Korchinski; Kamal K Midha
The metabolism of piperidine-type phenothiazine antipsychotic agents. II. Sulforidazine in dog and human.
Xenobiotica; the fate of foreign compounds in biological systems 1993;23(1):27-36.
1992: H Luo; Edward M Hawes; Gordon McKay; Kamal K Midha
Synthesis and characterization of quaternary ammonium-linked glucuronide metabolites of drugs with an aliphatic tertiary amine group.
Journal of pharmaceutical sciences 1992;81(11):1079-83.
1992: G Lin; Edward M Hawes; Gordon McKay; Kamal K Midha
The metabolism of piperidine-type phenothiazine antipsychotic agents. I. Sulforidazine in the rat.
Xenobiotica; the fate of foreign compounds in biological systems 1992;22(3):303-17.
1992: Kamal K Midha; John W Hubbard; Gordon McKay; Edward M Hawes; E D Korchinski; T Gurnsey; J K Cooper; R Schwede
Stereoselective pharmacokinetics of doxepin isomers.
European journal of clinical pharmacology 1992;42(5):539-44.
1991: T J Jaworski; Edward M Hawes; John W Hubbard; Gordon McKay; Kamal K Midha
The metabolites of chlorpromazine N-oxide in rat bile.
Xenobiotica; the fate of foreign compounds in biological systems 1991;21(11):1451-9.
1991: G Muralidharan; Edward M Hawes; Gordon McKay; Kamal K Midha
Quinine is a more potent inhibitor than quinidine in rat of the oxidative metabolic routes of methoxyphenamine which involve debrisoquine 4-hydroxylase.
Xenobiotica; the fate of foreign compounds in biological systems 1991;21(11):1441-50.
1991: H Luo; Edward M Hawes; Gordon McKay; E D Korchinski; Kamal K Midha
N(+)-glucuronidation of aliphatic tertiary amines, a general phenomenon in the metabolism of H1-antihistamines in humans.
Xenobiotica; the fate of foreign compounds in biological systems 1991;21(10):1281-8.
1991: H Luo; Edward M Hawes; Gordon McKay; E D Korchinski; Kamal K Midha
The quaternary ammonium-linked glucuronide of doxepin: a major metabolite in depressed patients treated with doxepin.
Drug metabolism and disposition: the biological fate of chemicals 1991;19(3):722-4.
1991: N R Srinivas; John W Hubbard; Gordon McKay; Edward M Hawes; Kamal K Midha
In vitro hydrolysis of RR,SS-threo-methylphenidate by blood esterases--differential and enantioselective interspecies variability.
Chirality 1991;3(2):99-103.
1991: G Muralidharan; Edward M Hawes; Gordon McKay; E D Korchinski; Kamal K Midha
Quinidine but not quinine inhibits in man the oxidative metabolic routes of methoxyphenamine which involve debrisoquine 4-hydroxylase.
European journal of clinical pharmacology 1991;41(5):471-4.
1991: C J Jackson; John W Hubbard; Gordon McKay; J K Cooper; Edward M Hawes; Kamal K Midha
Identification of phase-I and phase-II metabolites of fluphenazine in rat bile. Intact glucuronide and sulfate conjugates.
Drug metabolism and disposition: the biological fate of chemicals 1991;19(1):188-93.
1991: Y Z Shu; John W Hubbard; Gordon McKay; Edward M Hawes; Kamal K Midha
Cis-flupentixol metabolites in rat plasma and bile. The first proof of glutathione conjugation at the exocyclic double bond.
Drug metabolism and disposition: the biological fate of chemicals 1991;19(1):154-62.
1990: Y Z Shu; John W Hubbard; Gordon McKay; Kamal K Midha
Identification of phenolic doxepin glucuronides from patient urine and rat bile.
Drug metabolism and disposition: the biological fate of chemicals 1990;18(6):1096-9.
1990: Y Z Shu; John W Hubbard; J K Cooper; Gordon McKay; E D Korchinski; R Kumar; Kamal K Midha
The identification of urinary metabolites of doxepin in patients.
Drug metabolism and disposition: the biological fate of chemicals 1990;18(5):735-41.
1990: Kamal K Midha; Gordon McKay; B S Chakraborty; M Young; Edward M Hawes; John W Hubbard; J K Cooper; E D Korchinski
Bioequivalence of two thorazine tablet formulations using radioimmunoassay and gas chromatographic-mass spectrometric methods.
Journal of pharmaceutical sciences 1990;79(3):196-201.
1990: Gordon McKay; T Steeves; J K Cooper; Edward M Hawes; Kamal K Midha
Development and application of a radioimmunoassay for fluphenazine based on monoclonal antibodies and its comparison with alternate assay methods.
Journal of pharmaceutical sciences 1990;79(3):240-3.
1990: T J Jaworski; Edward M Hawes; Gordon McKay; Kamal K Midha
The metabolism of chlorpromazine N-oxide in man and dog.
Xenobiotica; the fate of foreign compounds in biological systems 1990;20(1):107-15.
1990: Kamal K Midha; B S Chakraborty; R Schwede; Edward M Hawes; Gordon McKay; John W Hubbard; J K Cooper; M Moore
Comparative bioavailability of two tablet formulations of fluphenazine dihydrochloride in drug-free psychiatric patients.
Journal of pharmaceutical sciences 1990;79(1):3-8.
1989: B S Chakraborty; Kamal K Midha; Gordon McKay; Edward M Hawes; John W Hubbard; E D Korchinski; MG Choc; W T Robinson
Single dose kinetics of thioridazine and its two psychoactive metabolites in healthy humans: a dose proportionality study.
Journal of pharmaceutical sciences 1989;78(10):796-801.
1989: Kamal K Midha; B S Chakraborty; R Schwede; Edward M Hawes; John W Hubbard; Gordon McKay
Comparative bioavailability of a new commercial tablet formulation and two lots of a reference formulation of haloperidol.
Journal of pharmaceutical sciences 1989;78(6):443-7.
1989: Kamal K Midha; B S Chakraborty; D A Ganes; Edward M Hawes; John W Hubbard; David Keegan; E D Korchinski; Gordon McKay
Intersubject variation in the pharmacokinetics of haloperidol and reduced haloperidol.
Journal of clinical psychopharmacology 1989;9(2):98-104.
1989: G Muralidharan; Kamal K Midha; Gordon McKay; Edward M Hawes; T Inaba
Selective in vivo inhibition by quinidine of methoxyphenamine oxidation in rat models of human debrisoquine polymorphism.
Xenobiotica; the fate of foreign compounds in biological systems 1989;19(2):189-97.
1989: Kamal K Midha; Edward M Hawes; John W Hubbard; E D Korchinski; Gordon McKay
Intersubject variation in the pharmacokinetics of chlorpromazine in healthy men.
Journal of clinical psychopharmacology 1989;9(1):4-8.
1989: N R Srinivas; John W Hubbard; Edward M Hawes; Gordon McKay; Kamal K Midha
Enantioselective gas chromatographic assays with electron-capture detection for methoxyphenamine and its three primary metabolites in human urine.
Journal of chromatography 1989;487(1):61-72.
1989: J K Cooper; Edward M Hawes; John W Hubbard; Gordon McKay; Kamal K Midha
An ultrasensitive method for the measurement of fluphenazine in plasma by high-performance liquid chromatography with coulometric detection.
Therapeutic drug monitoring 1989;11(3):354-60.
1989: B S Chakraborty; John W Hubbard; Edward M Hawes; Gordon McKay; J K Cooper; T Gurnsey; E D Korchinski; Kamal K Midha
Interconversion between haloperidol and reduced haloperidol in healthy volunteers.
European journal of clinical pharmacology 1989;37(1):45-8.
1988: T J Jaworski; Edward M Hawes; Gordon McKay; Kamal K Midha
The metabolism of chlorpromazine N-oxide in the rat.
Xenobiotica; the fate of foreign compounds in biological systems 1988;18(12):1439-47.
1988: A K Chaudhary; John W Hubbard; Gordon McKay; Kamal K Midha
Identification of a quaternary ammonium-linked glucuronide of chlorpromazine in the urine of a schizophrenic patient treated with chlorpromazine.
Drug metabolism and disposition: the biological fate of chemicals 1988;16(3):506-8.
1988: Kamal K Midha; Edward M Hawes; John W Hubbard; Gordon McKay; G Rauw; M S Sardessai; Manickam Aravagiri; M D Moore
Radioimmunoassay for fluphenazine sulfoxide in human plasma.
Journal of pharmacological methods 1988;19(1):63-74.
1988: Kamal K Midha; J K Cooper; Edward M Hawes; John W Hubbard; E D Korchinski; Gordon McKay
An ultrasensitive method for the measurement of haloperidol and reduced haloperidol in plasma by high-performance liquid chromatography with coulometric detection.
Therapeutic drug monitoring 1988;10(2):177-83.
1988: B S Chakraborty; Edward M Hawes; Gordon McKay; John W Hubbard; E D Korchinski; Kamal K Midha; MG Choc; W T Robinson
S-oxidation of thioridazine to psychoactive metabolites: an oral dose-proportionality study in healthy volunteers.
Drug metabolism and drug interactions 1988;6(3-4):425-37.
1988: Kamal K Midha; Edward M Hawes; John W Hubbard; E D Korchinski; Gordon McKay
Variation in the single dose pharmacokinetics of fluphenazine in psychiatric patients.
Psychopharmacology 1988;96(2):206-11.
1988: Kamal K Midha; Edward M Hawes; John W Hubbard; E D Korchinski; Gordon McKay
A pharmacokinetic study of trifluoperazine in two ethnic populations.
Psychopharmacology 1988;95(3):333-8.
1987: Kamal K Midha; John W Hubbard; J K Cooper; T Gurnsey; Edward M Hawes; Gordon McKay; B S Chakraborty; Pollen K F Yeung
Therapeutic monitoring of chlorpromazine. IV: Comparison of a new high-performance liquid chromatographic method with radioimmunoassays for parent drug and some of its major metabolites.
Therapeutic drug monitoring 1987;9(3):358-65.
1987: Kamal K Midha; John W Hubbard; Stephen R Marder; Edward M Hawes; T Van Putten; Gordon McKay; P R May
The sulfoxidation of fluphenazine in schizophrenic patients maintained on fluphenazine decanoate.
Psychopharmacology 1987;93(3):369-73.
1986: Stephen R Marder; John W Hubbard; T Van Putten; Edward M Hawes; Gordon McKay; Jim Mintz; P R May; Kamal K Midha
Plasma fluphenazine levels in patients receiving two doses of fluphenazine decanoate.
Psychopharmacology bulletin 1986;22(1):264-6.
1986: Stephen R Marder; Edward M Hawes; T Van Putten; John W Hubbard; Gordon McKay; Jim Mintz; P R May; Kamal K Midha
Fluphenazine plasma levels in patients receiving low and conventional doses of fluphenazine decanoate.
Psychopharmacology 1986;88(4):480-3.
1985: John W Hubbard; J K Cooper; Edward M Hawes; D J Jenden; P R May; M Martin; Gordon McKay; T Van Putten; Kamal K Midha
Therapeutic monitoring of chlorpromazine I: Pitfalls in plasma analysis.
Therapeutic drug monitoring 1985;7(2):222-8.
1984: Gordon McKay; G A Rauw; M D Stonkus; R A Dulos; R G Gedir; Edward M Hawes; Kamal K Midha
Radioimmunoassay for trimeprazine in human plasma.
Journal of pharmacological methods 1984;12(3):203-11.
1984: Kamal K Midha; G Rauw; Gordon McKay; J K Cooper; J McVittie
Subnanogram quantitation of chlorpheniramine in plasma by a new radioimmunoassay and comparison with a liquid chromatographic method.
Journal of pharmaceutical sciences 1984;73(8):1144-7.
1984: Edward M Hawes; H U Shetty; J K Cooper; G Rauw; Gordon McKay; Kamal K Midha
Radioimmunoassay for psychotropic drugs. III: Synthesis and properties of haptens for trifluoperazine and fluphenazine.
Journal of pharmaceutical sciences 1984;73(2):247-50.
1983: Kamal K Midha; Edward M Hawes; Gordon McKay; John W Hubbard; E D Korchinski; David Keegan
Plasma concentrations of trifluoperazine following single low doses.
Canadian Medical Association journal 1983;129(4):324.
1983: Kamal K Midha; Edward M Hawes; G Rauw; Gordon McKay; J K Cooper; H U Shetty
Development of radioimmunoassays for trifluoperazine and their application to metabolic studies of the drug.
Journal of pharmacological methods 1983;9(4):283-93.
1983: Kamal K Midha; Edward M Hawes; G Rauw; J McVittie; Gordon McKay; J K Cooper; H U Shetty
Radioimmunoassay for prochlorperazine in human plasma.
Therapeutic drug monitoring 1983;5(1):117-21.
1983: Gordon McKay; J Geddes; M J Cowper; T S Gurnsey
Recent advances in the analysis of phenothiazine drugs and their metabolites using high performance liquid chromatography.
Progress in neuro-psychopharmacology & biological psychiatry 1983;7(4-6):703-7.