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Jane McKeating

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Laetitia Zona; Amy Barnes; Laurent Brino; François-Loïc Cosset; François H T Duong; Sarah C Durand; Jonathan Florentin; Helen J Harris; Markus H Heim; Ivan Hirsch; François Le Naour; Joachim Lupberger; Jane A McKeating; Didier Samuel; Nazha Sidahmed-Adrar; Rajiv G Tawar; Christine Thumann; Marine Turek; Fei Xiao; Mirjam B Zeisel; Thomas F Baumert
HRas signal transduction promotes hepatitis C virus cell entry by triggering assembly of the host tetraspanin receptor complex.
H J Harris; K Hu; S C Ijzendoorn; Peter Balfe; C Clerte; Patrice Dosset; M J Farquhar; M Goodall; Pierre-Emmanuel Milhiet; P Rassam; G K Wilson; Jane A McKeating
Hepatoma polarization limits CD81 and hepatitis C virus dynamics.
Courtney Wilkins; Jessica Woodward; Amy Barnes; Michael Joyce; Daryl T-Y Lau; Nicola McFarlane; Jane A McKeating; D Lorne Tyrrell; Michael Gale
IFITM1 is a tight junction protein that inhibits hepatitis C virus entry.

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All Publications

2013: Laetitia Zona; Amy Barnes; Laurent Brino; François-Loïc Cosset; François H T Duong; Sarah C Durand; Jonathan Florentin; Helen J Harris; Markus H Heim; Ivan Hirsch; François Le Naour; Joachim Lupberger; Jane A McKeating; Didier Samuel; Nazha Sidahmed-Adrar; Rajiv G Tawar; Christine Thumann; Marine Turek; Fei Xiao; Mirjam B Zeisel; Thomas F Baumert
HRas signal transduction promotes hepatitis C virus cell entry by triggering assembly of the host tetraspanin receptor complex.
Cell host & microbe 2013;13(3):302-13.
2013: H J Harris; K Hu; S C Ijzendoorn; Peter Balfe; C Clerte; Patrice Dosset; M J Farquhar; M Goodall; Pierre-Emmanuel Milhiet; P Rassam; G K Wilson; Jane A McKeating
Hepatoma polarization limits CD81 and hepatitis C virus dynamics.
Cellular microbiology 2013;15(3):430-45.
2013: Courtney Wilkins; Jessica Woodward; Amy Barnes; Michael Joyce; Daryl T-Y Lau; Nicola McFarlane; Jane A McKeating; D Lorne Tyrrell; Michael Gale
IFITM1 is a tight junction protein that inhibits hepatitis C virus entry.
Hepatology (Baltimore, Md.) 2013;57(2):461-9.
2013: Helen J Harris; Stefan G Hübscher; Garrick K Wilson; Jane A McKeating
Heterogeneous claudin-1 expression in human liver.
Hepatology (Baltimore, Md.) 2013;57(2):854-5.
2012: Christopher Davis; Heidi E Drummer; Helen J Harris; Ke Hu; Jane A McKeating; Jonathan G L Mullins; Peter Balfe
In silico directed mutagenesis identifies the CD81/claudin-1 hepatitis C virus receptor interface.
Cellular microbiology 2012;14(12):1892-903.
2012: Richard J P Brown; Ke Hu; Natalia Hudson; Sara Jabbari; Michael Joyce; Norman Kneteman; Mansun Law; Jamie Lewis; Jane A McKeating; Shafiq Ur Rehman; Alexander W Tarr; D Lorne Tyrrell; Garrick Wilson; Lin Fu Zhu; Persephone Borrow; Jonathan K Ball
Hepatitis C virus envelope glycoprotein fitness defines virus population composition following transmission to a new host.
Journal of virology 2012;86(22):11956-66.
2012: N F Fletcher; Jane A McKeating
Hepatitis C virus and the brain.
Journal of viral hepatitis 2012;19(5):301-6.
2012: Luke W Meredith; Garrick K Wilson; Nicola F Fletcher; Jane A McKeating
Hepatitis C virus entry: beyond receptors.
Reviews in medical virology 2012;22(3):182-93.
2012: Michelle J Farquhar; Sarah J Fletcher; Helen J Harris; Ke Hu; Peter Balfe; Thomas F Baumert; Claire L Brimacombe; Christopher Davis; Joshua Z Rappoport; Jane A McKeating
Hepatitis C virus induces CD81 and claudin-1 endocytosis.
Journal of virology 2012;86(8):4305-16.
2012: Garrick K Wilson; Christopher J Mee; Ragai R Mitry; Gary M Reynolds; Ian A Rowe; Maria L Simões; Zania Stamataki; Simon C Afford; Margaret Ashcroft; Peter Balfe; Ricky H Bhogal; Claire L Brimacombe; Anil Dhawan; Nicola F Fletcher; Stefan G Hübscher; Jane A McKeating
A dual role for hypoxia inducible factor-1α in the hepatitis C virus lifecycle and hepatoma migration.
Journal of hepatology 2012;56(4):803-9.
2012: Nicola F Fletcher; Colin Howard; Jane A McKeating
Over the fence or through the gate: how viruses infect polarized cells.
Immunotherapy 2012;4(3):249-51.
2012: Alexander W Tarr; Richard Urbanowicz; Richard J P Brown; William L Irving; Dhanya Jayaraj; Jane A McKeating; Jonathan K Ball
Naturally occurring antibodies that recognize linear epitopes in the amino terminus of the hepatitis C virus E2 protein confer noninterfering, additive neutralization.
Journal of virology 2012;86(5):2739-49.
2012: Nicola F Fletcher; Ke Hu; Catherine Jopling; Kwang S Kim; Andrew Lewis; Miguel A Lopez-Ramirez; Guangxiang Luo; Luke W Meredith; Susan Morgello; Jacinta Murray; Gary M Reynolds; Ignacio A Romero; Ian A Rowe; Zania Stamataki; Babette Weksler; Garrick K Wilson; Peter Balfe; Thomas F Baumert; Pierre-Olivier Couraud; Jane A McKeating
Hepatitis C virus infects the endothelial cells of the blood-brain barrier.
Gastroenterology 2012;142(3):634-643.e6.
2011: Zania Stamataki; Sergio Abrignani; Stephen R Coates; Michael Houghton; Jane A McKeating
Immunization of human volunteers with hepatitis C virus envelope glycoproteins elicits antibodies that cross-neutralize heterologous virus strains.
The Journal of infectious diseases 2011;204(5):811-3.
2011: Danijela Petrovic; Zania Stamataki; Eugene Dempsey; Lucy Golden-Mason; Michael Freeley; Derek Doherty; David Prichard; Catherine Keogh; Jennifer Conroy; Siobhan Mitchell; Yuri Volkov; Jane A McKeating; Cliona O'Farrelly; Dermot Kelleher; Aideen Long
Hepatitis C virus targets the T cell secretory machinery as a mechanism of immune evasion.
Hepatology (Baltimore, Md.) 2011;53(6):1846-53.
2011: Joachim Lupberger; Mirjam B Zeisel; Fei Xiao; Christine Thumann; Isabel Fofana; Laetitia Zona; Christopher Davis; Christopher J Mee; Marine Turek; Sebastian Gorke; Cathy Royer; Benoit Fischer; Muhammad N Zahid; Dimitri Lavillette; Judith Fresquet; François-Loïc Cosset; S Michael Rothenberg; Thomas Pietschmann; Arvind H Patel; Patrick Pessaux; Michel Doffoël; Wolfgang Raffelsberger; Olivier Poch; Jane A McKeating; Laurent Brino; Thomas F Baumert
EGFR and EphA2 are host factors for hepatitis C virus entry and possible targets for antiviral therapy.
Nature medicine 2011;17(5):589-95.
2011: Nicklas Bonander; Mohammed Jamshad; Ke Hu; Michelle J Farquhar; Zania Stamataki; Peter Balfe; Jane A McKeating; Roslyn M Bill
Structural characterization of CD81-Claudin-1 hepatitis C virus receptor complexes.
Biochemical Society transactions 2011;39(2):537-40.
2011: Michelle J Farquhar; Helen J Harris; Jane A McKeating
Hepatitis C virus entry and the tetraspanin CD81.
Biochemical Society transactions 2011;39(2):532-6.
2011: Zania Stamataki; Samantha Tilakaratne; David H Adams; Jane A McKeating
Rituximab treatment in hepatitis C infection: an in vitro model to study the impact of B cell depletion on virus infectivity.
PloS one 2011;6(9):e25789.
2011: Claire L Brimacombe; Joe Grove; Luke W Meredith; Ke Hu; Andrew J Syder; Maria Victoria Flores; Jennifer Timpe; Sophie E Krieger; Thomas F Baumert; Timothy L Tellinghuisen; Flossie Wong-Staal; Peter Balfe; Jane A McKeating
Neutralizing antibody-resistant hepatitis C virus cell-to-cell transmission.
Journal of virology 2011;85(1):596-605.
2011: Andrew J Syder; Haekyung Lee; Mirjam B Zeisel; Joe Grove; Eric Soulier; James Macdonald; Stephine Chow; Julia Chang; Thomas F Baumert; Jane A McKeating; Jeffrey McKelvy; Flossie Wong-Staal
Small molecule scavenger receptor BI antagonists are potent HCV entry inhibitors.
Journal of hepatology 2011;54(1):48-55.
2010: Nicola F Fletcher; Jian Ping Yang; Michelle J Farquhar; Ke Hu; Christopher Davis; Qiuchen He; Kimberly Dowd; Stuart C Ray; Sophie E Krieger; Johan Neyts; Thomas F Baumert; Peter Balfe; Jane A McKeating; Flossie Wong-Staal
Hepatitis C virus infection of neuroepithelioma cell lines.
Gastroenterology 2010;139(4):1365-74.
2010: Isabel Fofana; Sophie E Krieger; Fritz Grunert; Sandra Glauben; Fei Xiao; Samira Fafi-Kremer; Eric Soulier; Cathy Royer; Christine Thumann; Christopher J Mee; Jane A McKeating; Tanya Dragic; Patrick Pessaux; Françoise Stoll-Keller; Catherine Schuster; John Thompson; Thomas F Baumert
Monoclonal anti-claudin 1 antibodies prevent hepatitis C virus infection of primary human hepatocytes.
Gastroenterology 2010;139(3):953-64, 964.e1-4.
2010: Jennifer A Thorley; Jane A McKeating; Joshua Z Rappoport
Mechanisms of viral entry: sneaking in the front door.
Protoplasma 2010;244(1-4):15-24.
2010: Helen J Harris; Christopher Davis; Jonathan G L Mullins; Ke Hu; Margaret Goodall; Michelle J Farquhar; Christopher J Mee; Kitty McCaffrey; Stephen Young; Heidi Drummer; Peter Balfe; Jane A McKeating
Claudin association with CD81 defines hepatitis C virus entry.
The Journal of biological chemistry 2010;285(27):21092-102.
2010: Jessica Wagoner; Amina Negash; Olivia J Kane; Laura E Martinez; Yaakov Nahmias; Nigel Bourne; David M Owen; Joe Grove; Claire Brimacombe; Jane A McKeating; Eve-Isabelle Pécheur; Tyler N Graf; Nicholas H Oberlies; Volker Lohmann; Feng Cao; John E Tavis; Stephen Polyak
Multiple effects of silymarin on the hepatitis C virus lifecycle.
Hepatology (Baltimore, Md.) 2010;51(6):1912-21.
2010: Stanley M Lemon; Jane A McKeating; Thomas Pietschmann; David N Frick; Jeffrey S Glenn; Timothy L Tellinghuisen; Julian Symons; Phillip A Furman
Development of novel therapies for hepatitis C.
Antiviral research 2010;86(1):79-92.
2010: Sophie E Krieger; Mirjam B Zeisel; Christopher Davis; Christine Thumann; Helen J Harris; Eva K Schnober; Christopher Mee; Eric Soulier; Cathy Royer; Mélanie Lambotin; Fritz Grunert; Viet Loan Dao Thi; Marlène Dreux; François-Loïc Cosset; Jane A McKeating; Catherine Schuster; Thomas F Baumert
Inhibition of hepatitis C virus infection by anti-claudin-1 antibodies is mediated by neutralization of E2-CD81-claudin-1 associations.
Hepatology (Baltimore, Md.) 2010;51(4):1144-57.
2010: Christopher J Mee; Michelle J Farquhar; Helen J Harris; Ke Hu; Wenda Ramma; Asif Ahmed; Patrick Maurel; Roy Bicknell; Peter Balfe; Jane A McKeating
Hepatitis C virus infection reduces hepatocellular polarity in a vascular endothelial growth factor-dependent manner.
Gastroenterology 2010;138(3):1134-42.
2009: Anne K Schwarz; Joe Grove; Ke Hu; Christopher J Mee; Peter Balfe; Jane A McKeating
Hepatoma cell density promotes claudin-1 and scavenger receptor BI expression and hepatitis C virus internalization.
Journal of virology 2009;83(23):12407-14.
2009: Peter Balfe; Jane A McKeating
The complexities of hepatitis C virus entry.
Journal of hepatology 2009;51(3):609-11.
2009: Christopher J Mee; Helen J Harris; Michelle J Farquhar; Garrick Wilson; Gary Reynolds; Christopher Davis; Sven C D van IJzendoorn; Peter Balfe; Jane A McKeating
Polarization restricts hepatitis C virus entry into HepG2 hepatoma cells.
Journal of virology 2009;83(12):6211-21.
2009: Zhen-Yong Keck; Sophia H Li; Jinming Xia; Thomas von Hahn; Peter Balfe; Jane A McKeating; Jeroen Witteveldt; Arvind H Patel; Harvey Alter; Charles M Rice; Steven K H Foung
Mutations in hepatitis C virus E2 located outside the CD81 binding sites lead to escape from broadly neutralizing antibodies but compromise virus infectivity.
Journal of virology 2009;83(12):6149-60.
2009: Zania Stamataki; Claire Shannon-Lowe; Jean Shaw; David Mutimer; Alan B Rickinson; John Gordon; David H Adams; Peter Balfe; Jane A McKeating
Hepatitis C virus association with peripheral blood B lymphocytes potentiates viral infection of liver-derived hepatoma cells.
Blood 2009;113(3):585-93.
2008: Meital Gal-Tanamy; Zhen-Yong Keck; MinKyung Yi; Jane A McKeating; Arvind H Patel; Steven K H Foung; Stanley M Lemon
In vitro selection of a neutralization-resistant hepatitis C virus escape mutant.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(49):19450-5.
2008: Joe Grove; Søren Nielsen; Jin Zhong; Margaret F Bassendine; Heidi E Drummer; Peter Balfe; Jane A McKeating
Identification of a residue in hepatitis C virus E2 glycoprotein that determines scavenger receptor BI and CD81 receptor dependency and sensitivity to neutralizing antibodies.
Journal of virology 2008;82(24):12020-9.
2008: Michelle Farquhar; Helen J Harris; Mandy Diskar; Sarah Jones; Christopher J Mee; Søren U Nielsen; Claire L Brimacombe; Sonia Molina; Geoffrey L Toms; Patrick Maurel; John Howl; Friedrich W Herberg; Sven C D van IJzendoorn; Peter Balfe; Jane A McKeating
Protein kinase A-dependent step(s) in hepatitis C virus entry and infectivity.
Journal of virology 2008;82(17):8797-811.
2008: Zania Stamataki; Joe Grove; Peter Balfe; Jane A McKeating
Hepatitis C virus entry and neutralization.
Clinics in liver disease 2008;12(3):693-712, x.
2008: Eishiro Mizukoshi; Christoph Eisenbach; Brian R Edlin; Kimberly P Newton; Sukanya Raghuraman; Christina Weiler-Normann; Leslie H Tobler; Michael P Busch; Mary Carrington; Jane A McKeating; Thomas R O'Brien; Barbara Rehermann
Hepatitis C virus (HCV)-specific immune responses of long-term injection drug users frequently exposed to HCV.
The Journal of infectious diseases 2008;198(2):203-12.
2008: Helen J Harris; Michelle Farquhar; Christopher J Mee; Christopher Davis; Gary M Reynolds; Adam Jennings; Ke Hu; Fei Yuan; HongKui Deng; Stefan G Hubscher; Jang H Han; Peter Balfe; Jane A McKeating
CD81 and claudin 1 coreceptor association: role in hepatitis C virus entry.
Journal of virology 2008;82(10):5007-20.
2008: Gary M Reynolds; Helen J Harris; Adam Jennings; Ke Hu; Joe Grove; Patricia F Lalor; David H Adams; Peter Balfe; Stefan G Hübscher; Jane A McKeating
Hepatitis C virus receptor expression in normal and diseased liver tissue.
Hepatology (Baltimore, Md.) 2008;47(2):418-27.
2008: Mohammed Jamshad; Sundaresan Rajesh; Zania Stamataki; Jane A McKeating; Timothy R Dafforn; Michael Overduin; Roslyn M Bill
Structural characterization of recombinant human CD81 produced in Pichia pastoris.
Protein expression and purification 2008;57(2):206-16.
2008: Mansun Law; Toshiaki Maruyama; Jamie Lewis; Erick Giang; Alexander W Tarr; Zania Stamataki; Pablo Gastaminza; Francis V Chisari; Ian M Jones; Robert I Fox; Jonathan K Ball; Jane A McKeating; Norman M Kneteman; Dennis R Burton
Broadly neutralizing antibodies protect against hepatitis C virus quasispecies challenge.
Nature medicine 2008;14(1):25-7.
2008: Christopher J Mee; Joe Grove; Helen J Harris; Ke Hu; Peter Balfe; Jane A McKeating
Effect of cell polarization on hepatitis C virus entry.
Journal of virology 2008;82(1):461-70.
2008: Sonia Molina; Valérie Castet; Lydiane Pichard-Garcia; Czeslaw Wychowski; Eliane F Meurs; Jean-Marc Pascussi; Camille Sureau; Jean-Michel Fabre; Antonio SaCunha; Dominique Larrey; Jean Dubuisson; Joliette Coste; Jane A McKeating; Patrick Maurel; Chantal Fournier-Wirth
Serum-derived hepatitis C virus infection of primary human hepatocytes is tetraspanin CD81 dependent.
Journal of virology 2008;82(1):569-74.
2008: Jennifer Timpe; Zania Stamataki; Adam Jennings; Ke Hu; Michelle Farquhar; Helen J Harris; Anne Schwarz; Isabelle Desombere; Geert Leroux Roels; Peter Balfe; Jane A McKeating
Hepatitis C virus cell-cell transmission in hepatoma cells in the presence of neutralizing antibodies.
Hepatology (Baltimore, Md.) 2008;47(1):17-24.
2007: Zania Stamataki; Stephen R Coates; Matthew J Evans; Mark Wininger; Kevin Crawford; Christine Dong; Yiu-Lian Fong; David Chien; Sergio Abrignani; Peter Balfe; Charles M Rice; Jane A McKeating; Michael Houghton
Hepatitis C virus envelope glycoprotein immunization of rodents elicits cross-reactive neutralizing antibodies.
Vaccine 2007;25(45):7773-84.
2007: Vincent Lai; Stuart M Curbishley; Sarah Goddard; Edward Alabraba; Jean Shaw; Janine Youster; Jane A McKeating; David H Adams
Hepatitis C is associated with perturbation of intrahepatic myeloid and plasmacytoid dendritic cell function.
Journal of hepatology 2007;47(3):338-47.
2007: François Helle; Anne Goffard; Virginie Morel; Gilles Duverlie; Jane A McKeating; Zhen-Yong Keck; Steven K H Foung; François Penin; Jean Dubuisson; Cécile Voisset
The neutralizing activity of anti-hepatitis C virus antibodies is modulated by specific glycans on the E2 envelope protein.
Journal of virology 2007;81(15):8101-11.
2007: Matthew J Evans; Thomas von Hahn; Donna M Tscherne; Andrew J Syder; Maryline Panis; Benno Wölk; Theodora Hatziioannou; Jane A McKeating; Paul D Bieniasz; Charles M Rice
Claudin-1 is a hepatitis C virus co-receptor required for a late step in entry.
Nature 2007;446(7137):801-5.
2007: Donna M Tscherne; Matthew J Evans; Thomas von Hahn; Christopher T Jones; Zania Stamataki; Jane A McKeating; Brett D Lindenbach; Charles M Rice
Superinfection exclusion in cells infected with hepatitis C virus.
Journal of virology 2007;81(8):3693-703.
2007: Joe Grove; Thierry Huby; Zania Stamataki; Thomas Vanwolleghem; Philip Meuleman; Michelle Farquhar; Anne Schwarz; Martine Moreau; James S Owen; Geert Leroux-Roels; Peter Balfe; Jane A McKeating
Scavenger receptor BI and BII expression levels modulate hepatitis C virus infectivity.
Journal of virology 2007;81(7):3162-9.
2007: Thomas von Hahn; Jane A McKeating
In vitro veritas? The challenges of studying hepatitis C virus infectivity in a test tube.
Journal of hepatology 2007;46(3):355-8.
2007: David Edward Kaplan; Kazushi Sugimoto; Kimberly Newton; Mary E Valiga; Fusao Ikeda; Ayse Aytaman; Frederick A Nunes; Michael R Lucey; Barbara A Vance; Robert H Vonderheide; K Rajender Reddy; Jane A McKeating; Kyong-Mi Chang
Discordant role of CD4 T-cell response relative to neutralizing antibody and CD8 T-cell responses in acute hepatitis C.
Gastroenterology 2007;132(2):654-66.
2007: Thomas von Hahn; Joo Chun Yoon; Harvey Alter; Charles M Rice; Barbara Rehermann; Peter Balfe; Jane A McKeating
Hepatitis C virus continuously escapes from neutralizing antibody and T-cell responses during chronic infection in vivo.
Gastroenterology 2007;132(2):667-78.
2007: Gerond Lake-Bakaar; Lynn Dustin; Jane A McKeating; Kimberley Newton; Victoria Freeman; Simon D W Frost
Hepatitis C virus and alanine aminotransferase kinetics following B-lymphocyte depletion with rituximab: evidence for a significant role of humoral immunity in the control of viremia in chronic HCV liver disease.
Blood 2007;109(2):845-6.
2007: Sharookh B Kapadia; Heidi Barth; Thomas Baumert; Jane A McKeating; Francis V Chisari
Initiation of hepatitis C virus infection is dependent on cholesterol and cooperativity between CD81 and scavenger receptor B type I.
Journal of virology 2007;81(1):374-83.
2006: Jin Zhong; Pablo Gastaminza; Josan Chung; Zania Stamataki; Masanori Isogawa; Guofeng Cheng; Jane A McKeating; Francis V Chisari
Persistent hepatitis C virus infection in vitro: coevolution of virus and host.
Journal of virology 2006;80(22):11082-93.
2006: Mike Flint; Thomas von Hahn; Jie Zhang; Michelle Farquhar; Christopher T Jones; Peter Balfe; Charles M Rice; Jane A McKeating
Diverse CD81 proteins support hepatitis C virus infection.
Journal of virology 2006;80(22):11331-42.
2006: Vincent Lai; Phoebe J Sun; Jie Zhang; Adam Jennings; Patricia F Lalor; Stefan G Hubscher; Jane A McKeating; David H Adams
Expression of DC-SIGN and DC-SIGNR on human sinusoidal endothelium: a role for capturing hepatitis C virus particles.
The American journal of pathology 2006;169(1):200-8.
2006: Thomas von Hahn; Brett D Lindenbach; Agnès Boullier; Oswald Quehenberger; Matthew Paulson; Charles M Rice; Jane A McKeating
Oxidized low-density lipoprotein inhibits hepatitis C virus cell entry in human hepatoma cells.
Hepatology (Baltimore, Md.) 2006;43(5):932-42.
2006: Brett D Lindenbach; Philip Meuleman; Alexander Ploss; Thomas Vanwolleghem; Andrew J Syder; Jane A McKeating; Robert E Lanford; Stephen M Feinstone; Marian E Major; Geert Leroux-Roels; Charles M Rice
Cell culture-grown hepatitis C virus is infectious in vivo and can be recultured in vitro.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(10):3805-9.
2006: Yves Rouillé; François Helle; David Delgrange; Philippe Roingeard; Cécile Voisset; Emmanuelle Blanchard; Sandrine Belouzard; Jane A McKeating; Arvind H Patel; Geert Maertens; Takaji Wakita; Czeslaw Wychowski; Jean Dubuisson
Subcellular localization of hepatitis C virus structural proteins in a cell culture system that efficiently replicates the virus.
Journal of virology 2006;80(6):2832-41.
2006: Donna M Tscherne; Christopher T Jones; Matthew J Evans; Brett D Lindenbach; Jane A McKeating; Charles M Rice
Time- and temperature-dependent activation of hepatitis C virus for low-pH-triggered entry.
Journal of virology 2006;80(4):1734-41.
2005: Dale Netski; Timothy Mosbruger; Erik Depla; Geert Maertens; Stuart C Ray; Robert G Hamilton; Stacy Roundtree; David L Thomas; Jane A McKeating; Andrea L Cox
Humoral immune response in acute hepatitis C virus infection.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2005;41(5):667-75.
2005: Brett D Lindenbach; Matthew J Evans; Andrew J Syder; Benno Wölk; Timothy L Tellinghuisen; Christopher C Liu; Toshiaki Maruyama; Richard O Hynes; Dennis R Burton; Jane A McKeating; Charles M Rice
Complete replication of hepatitis C virus in cell culture.
Science (New York, N.Y.) 2005;309(5734):623-6.
2004: Jane A McKeating; L Q Zhang; Carine Logvinoff; Mike Flint; Jie Zhang; Jian Yu; David Butera; David D Ho; Lynn B Dustin; Charles M Rice; Peter Balfe
Diverse hepatitis C virus glycoproteins mediate viral infection in a CD81-dependent manner.
Journal of virology 2004;78(16):8496-505.
2004: Carine Logvinoff; Marian E Major; David W Oldach; S Heyward; Andrew H Talal; Peter Balfe; Stephen M Feinstone; Harvey Alter; Charles M Rice; Jane A McKeating
Neutralizing antibody response during acute and chronic hepatitis C virus infection.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(27):10149-54.
2004: Mike Flint; Carine Logvinoff; Charles M Rice; Jane A McKeating
Characterization of infectious retroviral pseudotype particles bearing hepatitis C virus glycoproteins.
Journal of virology 2004;78(13):6875-82.
2004: Jie Zhang; Glenn Randall; Adrian Higginbottom; Peter N Monk; Charles M Rice; Jane A McKeating
CD81 is required for hepatitis C virus glycoprotein-mediated viral infection.
Journal of virology 2004;78(3):1448-55.
2003: Mayla Hsu; Jie Zhang; Mike Flint; Carine Logvinoff; Cecilia Cheng-Mayer; Charles M Rice; Jane A McKeating
Hepatitis C virus glycoproteins mediate pH-dependent cell entry of pseudotyped retroviral particles.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(12):7271-6.
2003: Stefan Pöhlmann; Jie Zhang; Frédéric Baribaud; Zhiwei Chen; George J Leslie; George Lin; Angela Granelli-Piperno; Robert W Doms; Charles M Rice; Jane A McKeating
Hepatitis C virus glycoproteins interact with DC-SIGN and DC-SIGNR.
Journal of virology 2003;77(7):4070-80.
2003: Keril J. Blight; Jane A McKeating; Joseph Marcotrigiano; Charles M Rice
Efficient replication of hepatitis C virus genotype 1a RNAs in cell culture.
Journal of virology 2003;77(5):3181-90.
2003: Rosa Maria Roccasecca; Helenia Ansuini; alessandra vitelli; Annalisa Meola; Elisa Scarselli; Stefano Acali; Monica Pezzanera; Bruno Bruni Ercole; Jane A McKeating; Asutosh Yagnik; Armin Lahm; Anna Tramontano; Riccardo Cortese; Alfredo Nicosia
Binding of the hepatitis C virus E2 glycoprotein to CD81 is strain specific and is modulated by a complex interplay between hypervariable regions 1 and 2.
Journal of virology 2003;77(3):1856-67.
2002: Keril J. Blight; Jane A McKeating; Charles M Rice
Highly permissive cell lines for subgenomic and genomic hepatitis C virus RNA replication.
Journal of virology 2002;76(24):13001-14.
2002: SA Jeffs; C Shotton; Peter Balfe; Jane A McKeating
Truncated gp120 envelope glycoprotein of human immunodeficiency virus 1 elicits a broadly reactive neutralizing immune response.
The Journal of general virology 2002;83(Pt 11):2723-32.
2002: Anja Mueller; Nasir G Mahmoud; Marc C Goedecke; Jane A McKeating; Philip G Strange
Pharmacological characterization of the chemokine receptor, CCR5.
British journal of pharmacology 2002;135(4):1033-43.
2001: Ania M Owsianka; Reginald F Clayton; L D Loomis-Price; Jane A McKeating; Arvind H Patel
Functional analysis of hepatitis C virus E2 glycoproteins and virus-like particles reveals structural dissimilarities between different forms of E2.
The Journal of general virology 2001;82(Pt 8):1877-83.
2001: A L Hammond; J Lewis; J May; J Albert; Peter Balfe; Jane A McKeating
Antigenic variation within the CD4 binding site of human immunodeficiency virus type 1 gp120: effects on chemokine receptor utilization.
Journal of virology 2001;75(12):5593-603.
2000: Arvind H Patel; J Wood; F Penin; Jean Dubuisson; Jane A McKeating
Construction and characterization of chimeric hepatitis C virus E2 glycoproteins: analysis of regions critical for glycoprotein aggregation and CD81 binding.
The Journal of general virology 2000;81(Pt 12):2873-83.
2000: Annalisa Meola; ANDREA SBARDELLATI; B Bruni Ercole; Mauro Cerretani; Monica Pezzanera; A Ceccacci; alessandra vitelli; S Levy; Alfredo Nicosia; Cinzia Traboni; Jane A McKeating; Elisa Scarselli
Binding of hepatitis C virus E2 glycoprotein to CD81 does not correlate with species permissiveness to infection.
Journal of virology 2000;74(13):5933-8.
2000: Adrian Higginbottom; Elizabeth Quinn; C C Kuo; Mike Flint; L H Wilson; E Bianchi; A Nicosia; Peter N Monk; Jane A McKeating; Shoshana Levy
Identification of amino acid residues in CD81 critical for interaction with hepatitis C virus envelope glycoprotein E2.
Journal of virology 2000;74(8):3642-9.
2000: Mike Flint; Jane A McKeating
The role of the hepatitis C virus glycoproteins in infection.
Reviews in medical virology 2000;10(2):101-17.
2000: Mike Flint; J Dubuisson; CM Maidens; R Harrop; G R Guile; P Borrow; Jane A McKeating
Functional characterization of intracellular and secreted forms of a truncated hepatitis C virus E2 glycoprotein.
Journal of virology 2000;74(2):702-9.
1999: Mike Flint; Jane A McKeating
The C-terminal region of the hepatitis C virus E1 glycoprotein confers localization within the endoplasmic reticulum.
The Journal of general virology 1999;80 ( Pt 8)():1943-7.
1999: Mike Flint; J M Thomas; CM Maidens; C Shotton; Shoshana Levy; Wendy S Barclay; Jane A McKeating
Functional analysis of cell surface-expressed hepatitis C virus E2 glycoprotein.
Journal of virology 1999;73(8):6782-90.
1999: Mike Flint; CM Maidens; L D Loomis-Price; C Shotton; J Dubuisson; Peter N Monk; Adrian Higginbottom; Shoshana Levy; Jane A McKeating
Characterization of hepatitis C virus E2 glycoprotein interaction with a putative cellular receptor, CD81.
Journal of virology 1999;73(8):6235-44.
1999: Jane A McKeating; Peter Balfe
The role of the viral glycoprotein in HIV-1 persistence.
Immunology letters 1999;65(1-2):63-70.
1998: J Lewis; Peter Balfe; Cath Arnold; S Kaye; Richard S Tedder; Jane A McKeating
Development of a neutralizing antibody response during acute primary human immunodeficiency virus type 1 infection and the emergence of antigenic variants.
Journal of virology 1998;72(11):8943-51.
1998: Peter Balfe; Y Churcher; M Penny; Philippa J Easterbrook; Ruth L Goodall; S Galpin; F Gotch; Rod S Daniels; Jane A McKeating
Association between a defective CCR-5 gene and progression to disease in HIV infection.
AIDS research and human retroviruses 1998;14(14):1229-34.
1997: D G Fox; Peter Balfe; C P Palmer; J C May; Cath Arnold; Jane A McKeating
Length polymorphism within the second variable region of the human immunodeficiency virus type 1 envelope glycoprotein affects accessibility of the receptor binding site.
Journal of virology 1997;71(1):759-65.
1996: Jane A McKeating
Biological consequences of human immunodeficiency virus type 1 envelope polymorphism: does variation matter? 1995 Fleming Lecture.
The Journal of general virology 1996;77 ( Pt 12)():2905-19.
1996: S A Jeffs; Jane A McKeating; S Lewis; H Craft; D Biram; P E Stephens; R L Brady
Antigenicity of truncated forms of the human immunodeficiency virus type 1 envelope glycoprotein.
The Journal of general virology 1996;77 ( Pt 7)():1403-10.
1996: Jane A McKeating; Y J Zhang; Cath Arnold; R Frederiksson; E M Fenyö; Peter Balfe
Chimeric viruses expressing primary envelope glycoproteins of human immunodeficiency virus type I show increased sensitivity to neutralization by human sera.
Virology 1996;220(2):450-60.
1996: C Palmer; Peter Balfe; D Fox; J C May; R Frederiksson; E M Fenyö; Jane A McKeating
Functional characterization of the V1V2 region of human immunodeficiency virus type 1.
Virology 1996;220(2):436-49.
1996: Jane A McKeating; C Shotton; S Jeffs; C Palmer; A Hammond; J Lewis; K Oliver; J May; Peter Balfe
Immunogenicity of full length and truncated forms of the human immunodeficiency virus type I envelope glycoprotein.
Immunology letters 1996;51(1-2):101-5.
1995: Z Wu; Samuel C Kayman; W Honnen; K Revesz; H Chen; S Vijh-Warrier; S A Tilley; Jane A McKeating; C Shotton; Abraham Pinter
Characterization of neutralization epitopes in the V2 region of human immunodeficiency virus type 1 gp120: role of glycosylation in the correct folding of the V1/V2 domain.
Journal of virology 1995;69(4):2271-8.
1995: C Shotton; C Arnold; Q Sattentau; Joseph Sodroski; Jane A McKeating
Identification and characterization of monoclonal antibodies specific for polymorphic antigenic determinants within the V2 region of the human immunodeficiency virus type 1 envelope glycoprotein.
Journal of virology 1995;69(1):222-30.
1994: C Rose; W Andrews; M Ferguson; Jane A McKeating; Jeffrey W Almond; D Evans
The construction and characterization of poliovirus antigen chimeras presenting defined regions of the human T lymphocyte marker CD4.
The Journal of general virology 1994;75 ( Pt 5)():969-77.
1993: N L Paul; M Marsh; Jane A McKeating; T F Schulz; P Liljeström; H Garoff; Robin A Weiss
Expression of HIV-1 envelope glycoproteins by Semliki Forest virus vectors.
AIDS research and human retroviruses 1993;9(10):963-70.
1993: Per Johan Klasse; Jane A McKeating; Martin Schutten; Marvin Reitz; M Robert-Guroff
An immune-selected point mutation in the transmembrane protein of human immunodeficiency virus type 1 (HXB2-Env:Ala 582(-->Thr)) decreases viral neutralization by monoclonal antibodies to the CD4-binding site.
Virology 1993;196(1):332-7.
1993: Jane A McKeating; J Bennett; Susan Zolla-Pazner; Martin Schutten; S Ashelford; A L Brown; Peter Balfe
Resistance of a human serum-selected human immunodeficiency virus type 1 escape mutant to neutralization by CD4 binding site monoclonal antibodies is conferred by a single amino acid change in gp120.
Journal of virology 1993;67(9):5216-25.
1993: Jane A McKeating; C Shotton; J Cordell; S Graham; Peter Balfe; N Sullivan; M Charles; M Page; Anders Bolmstedt; Sven-Olof Olofsson
Characterization of neutralizing monoclonal antibodies to linear and conformation-dependent epitopes within the first and second variable domains of human immunodeficiency virus type 1 gp120.
Journal of virology 1993;67(8):4932-44.
1993: Per Johan Klasse; Jane A McKeating
Soluble CD4 and CD4 immunoglobulin-selected HIV-1 variants: a phenotypic characterization.
AIDS research and human retroviruses 1993;9(7):595-604.
1993: Martin Schutten; Aine McKnight; R C Huisman; M Thali; Jane A McKeating; Joseph Sodroski; J Goudsmit; A D Osterhaus
Further characterization of an antigenic site of HIV-1 gp120 recognized by virus neutralizing human monoclonal antibodies.
AIDS (London, England) 1993;7(7):919-23.
1992: Jane A McKeating; J Cordell; C J Dean; Peter Balfe
Synergistic interaction between ligands binding to the CD4 binding site and V3 domain of human immunodeficiency virus type I gp120.
Virology 1992;191(2):732-42.
1992: Jane A McKeating; M Thali; C Furman; S Karwowska; Miroslaw K Gorny; J Cordell; Susan Zolla-Pazner; Joseph Sodroski; Robin A Weiss
Amino acid residues of the human immunodeficiency virus type I gp120 critical for the binding of rat and human neutralizing antibodies that block the gp120-sCD4 interaction.
Virology 1992;190(1):134-42.
1992: J P Moore; G Simpson; Jane A McKeating; S J Burakoff; S L Schreiber; Robin A Weiss
CPF-DD is an inhibitor of infection by human immunodeficiency virus and other enveloped viruses in vitro.
Virology 1992;188(2):537-44.
1992: Jane A McKeating
CD4 antagonists.
Biochemical Society transactions 1992;20(2):521-5.
1992: J P Moore; Jane A McKeating; Y X Huang; A Ashkenazi; D D Ho
Virions of primary human immunodeficiency virus type 1 isolates resistant to soluble CD4 (sCD4) neutralization differ in sCD4 binding and glycoprotein gp120 retention from sCD4-sensitive isolates.
Journal of virology 1992;66(1):235-43.
1991: J Cordell; J P Moore; C J Dean; Per Johan Klasse; Robin A Weiss; Jane A McKeating
Rat monoclonal antibodies to nonoverlapping epitopes of human immunodeficiency virus type 1 gp120 block CD4 binding in vitro.
Virology 1991;185(1):72-9.
1991: Jane A McKeating; Peter Balfe; Paul R Clapham; Robin A Weiss
Recombinant CD4-selected human immunodeficiency virus type 1 variants with reduced gp120 affinity for CD4 and increased cell fusion capacity.
Journal of virology 1991;65(9):4777-85.
1991: J P Moore; Jane A McKeating; W A Norton; Quentin J Sattentau
Direct measurement of soluble CD4 binding to human immunodeficiency virus type 1 virions: gp120 dissociation and its implications for virus-cell binding and fusion reactions and their neutralization by soluble CD4.
Journal of virology 1991;65(3):1133-40.
1991: Jane A McKeating; Aine McKnight; J P Moore
Differential loss of envelope glycoprotein gp120 from virions of human immunodeficiency virus type 1 isolates: effects on infectivity and neutralization.
Journal of virology 1991;65(2):852-60.
1991: G J Clements; M J Price-Jones; P E Stephens; C Sutton; T F Schulz; Paul R Clapham; Jane A McKeating; Myra O McClure; S Thomson; M Marsh
The V3 loops of the HIV-1 and HIV-2 surface glycoproteins contain proteolytic cleavage sites: a possible function in viral fusion?
AIDS research and human retroviruses 1991;7(1):3-16.
1991: K S Steimer; Per Johan Klasse; Jane A McKeating
HIV-1 neutralization directed to epitopes other than linear V3 determinants.
AIDS (London, England) 1991;5 Suppl 2():S135-43.
1990: J P Moore; Jane A McKeating; Robin A Weiss; Quentin J Sattentau
Dissociation of gp120 from HIV-1 virions induced by soluble CD4.
Science (New York, N.Y.) 1990;250(4984):1139-42.
1990: J P Moore; Jane A McKeating; I M Jones; P E Stephens; G Clements; S Thomson; Robin A Weiss
Characterization of recombinant gp120 and gp160 from HIV-1: binding to monoclonal antibodies and soluble CD4.
AIDS (London, England) 1990;4(4):307-15.
1990: Jane A McKeating; P D Griffiths; Robin A Weiss
HIV susceptibility conferred to human fibroblasts by cytomegalovirus-induced Fc receptor.
Nature 1990;343(6259):659-61.
1989: Jane A McKeating; Aine McKnight; K McIntosh; Paul R Clapham; C Mulder; Robin A Weiss
Evaluation of human and simian immunodeficiency virus plaque and neutralization assays.
The Journal of general virology 1989;70 ( Pt 12)():3327-33.
1989: Jane A McKeating; J Gow; J Goudsmit; L H Pearl; C Mulder; Robin A Weiss
Characterization of HIV-1 neutralization escape mutants.
AIDS (London, England) 1989;3(12):777-84.
1989: J Weber; Paul R Clapham; Jane A McKeating; M Stratton; E Robey; R Weiss
Infection of brain cells by diverse human immunodeficiency virus isolates: role of CD4 as receptor.
The Journal of general virology 1989;70 ( Pt 10)():2653-60.
1989: David J Evans; Jane A McKeating; J M Meredith; K L Burke; K Katrak; A John; M Ferguson; Philip D Minor; R A Weiss; Jeffrey W Almond
An engineered poliovirus chimaera elicits broadly reactive HIV-1 neutralizing antibodies.
Nature 1989;339(6223):385-8, 340.
1989: Myra O McClure; T F Schulz; R S Tedder; J Gow; Jane A McKeating; Robin A Weiss; A Baskerville
Inoculation of New World primates with the human immunodeficiency virus.
Journal of medical primatology 1989;18(3-4):329-35.
1989: Jane A McKeating; R L Willey
Structure and function of the HIV envelope.
AIDS (London, England) 1989;3 Suppl 1():S35-41.
1988: Robin A Weiss; Paul R Clapham; Myra O McClure; Jane A McKeating; Aine McKnight; A G Dalgleish; Quentin J Sattentau; J N Weber
Human immunodeficiency viruses: neutralization and receptors.
Journal of acquired immune deficiency syndromes 1988;1(6):536-41.

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