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Timothy McKeithan

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Radha M Golla; Timothy C Greiner; Ming Ji; Min Li; Timothy W McKeithan; Yulei Shen; Ying Yan; Kai Fu; Wing C Chan
Inhibition of poly(ADP-ribose) polymerase (PARP) and ataxia telangiectasia mutated (ATM) on the chemosensitivity of mantle cell lymphoma to agents that induce DNA strand breaks.
Xin Huang; Javeed Iqbal; Chunsun Jiang; Miao Liu; Timothy W McKeithan; Yulei Shen; Chengfeng Bi; Wing C Chan; Shi-Jian Ding; Kai Fu
Quantitative proteomics reveals that miR-155 regulates the PI3K-AKT pathway in diffuse large B-cell lymphoma.
Javeed Iqbal; Elaine S Jaffe; Cynthia M Lachel; Cuiling Liu; Yanyan Liu; Zhongfeng Liu; Timothy W McKeithan; German Ott; Lisa M Rimsza; Andreas Rosenwald; Yulei Shen; Louis M Staudt; Raymond R Tubbs; Julie M Vose; Dennis D Weisenburger; James O Armitage; Sharathkumar Bhagavathi; Rita M Braziel; Elias Campo; James R Cook; Karen Deffenbacher; Jan Delabie; Kai Fu; Randy D Gascoyne; Timothy C Greiner; Wing C Chan
Genome-wide miRNA profiling of mantle cell lymphoma reveals a distinct subgroup with poor prognosis.

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All Publications

2012: Radha M Golla; Timothy C Greiner; Ming Ji; Min Li; Timothy W McKeithan; Yulei Shen; Ying Yan; Kai Fu; Wing C Chan
Inhibition of poly(ADP-ribose) polymerase (PARP) and ataxia telangiectasia mutated (ATM) on the chemosensitivity of mantle cell lymphoma to agents that induce DNA strand breaks.
Hematological oncology 2012;30(4):175-9.
2012: Xin Huang; Javeed Iqbal; Chunsun Jiang; Miao Liu; Timothy W McKeithan; Yulei Shen; Chengfeng Bi; Wing C Chan; Shi-Jian Ding; Kai Fu
Quantitative proteomics reveals that miR-155 regulates the PI3K-AKT pathway in diffuse large B-cell lymphoma.
The American journal of pathology 2012;181(1):26-33.
2012: Javeed Iqbal; Elaine S Jaffe; Cynthia M Lachel; Cuiling Liu; Yanyan Liu; Zhongfeng Liu; Timothy W McKeithan; German Ott; Lisa M Rimsza; Andreas Rosenwald; Yulei Shen; Louis M Staudt; Raymond R Tubbs; Julie M Vose; Dennis D Weisenburger; James O Armitage; Sharathkumar Bhagavathi; Rita M Braziel; Elias Campo; James R Cook; Karen Deffenbacher; Jan Delabie; Kai Fu; Randy D Gascoyne; Timothy C Greiner; Wing C Chan
Genome-wide miRNA profiling of mantle cell lymphoma reveals a distinct subgroup with poor prognosis.
Blood 2012;119(21):4939-48.
2011: Ming Ji; Chunsun Jiang; Wing C Chan; Jianxiu Chen; Kai Fu; Yiqiao Hu; Himabindu Ramachandrareddy; Enyu Rao; Angie Rizzino; Yulei Shen; Timothy W McKeithan
The miR-17-92 microRNA cluster is regulated by multiple mechanisms in B-cell malignancies.
The American journal of pathology 2011;179(4):1645-56.
2010: Himabindu Ramachandrareddy; Alyssa Bouska; Yulei Shen; Ming Ji; Angie Rizzino; Wing C Chan; Timothy W McKeithan
BCL6 promoter interacts with far upstream sequences with greatly enhanced activating histone modifications in germinal center B cells.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(26):11930-5.
2010: Javeed Iqbal; Dennis D Weisenburger; Timothy C Greiner; Julie M Vose; Timothy W McKeithan; Can Kucuk; Huimin Geng; Karen Deffenbacher; Lynette Smith; Karen Dybkaer; Shigeo Nakamura; Masao Seto; Jan Delabie; Francoise Berger; Florence Loong; Wing Y Au; Young Hyeh Ko; Ivy Sng; James Olen Armitage; Wing C Chan
Molecular signatures to improve diagnosis in peripheral T-cell lymphoma and prognostication in angioimmunoblastic T-cell lymphoma.
Blood 2010;115(5):1026-36.
2008: Yulei Shen; Baosheng Ge; Himabindu Ramachandrareddy; Timothy W McKeithan; Wing C Chan
Alternative splicing generates a short BCL6 (BCL6S) isoform encoding a compact repressor.
Biochemical and biophysical research communications 2008;375(2):190-3.
2008: Harini Chakravarthy; Brian Boer; Michelle Desler; Sunil Kumar Mallanna; Timothy W McKeithan; Angie Rizzino
Identification of DPPA4 and other genes as putative Sox2:Oct-3/4 target genes using a combination of in silico analysis and transcription-based assays.
Journal of cellular physiology 2008;216(3):651-62.
2007: Javeed Iqbal; Timothy C Greiner; K Patel; Bhavana J Dave; L Smith; J Ji; George Wright; Warren G Sanger; Diane L Pickering; S Jain; Douglas E Horsman; Y Shen; Kai Fu; Dennis D Weisenburger; Christine P Hans; Elias Campo; Randy D Gascoyne; Andreas Rosenwald; Elaine S Jaffe; Jan Delabie; Lisa M Rimsza; German Ott; Hans Konrad Müller-Hermelink; Joseph Michael Connors; Julie M Vose; Timothy W McKeithan; Louis M Staudt; Wing C Chan
Distinctive patterns of BCL6 molecular alterations and their functional consequences in different subgroups of diffuse large B-cell lymphoma.
Leukemia 2007;21(11):2332-43.
2007: Zenggang Pan; Yulei Shen; Baosheng Ge; Cheng Du; Timothy W McKeithan; Wing C Chan
Studies of a germinal centre B-cell expressed gene, GCET2, suggest its role as a membrane associated adapter protein.
British journal of haematology 2007;137(6):578-90.
2006: Katja Brocke-Heidrich; B Ge; H Cvijic; Gabriele Pfeifer; Dennis Löffler; Christian Henze; Timothy W McKeithan; Friedemann Horn
BCL3 is induced by IL-6 via Stat3 binding to intronic enhancer HS4 and represses its own transcription.
Oncogene 2006;25(55):7297-304.
2006: Cheng Du; Baosheng Ge; Xiaoyan Feng; Wing C Chan; Timothy W McKeithan
Generation of variable and fixed length siRNA from a novel siRNA expression vector.
Biochemical and biophysical research communications 2006;345(1):99-105.
2006: Cheng Du; Baosheng Ge; Zhongfeng Liu; Kai Fu; Wing C Chan; Timothy W McKeithan
PCR-based generation of shRNA libraries from cDNAs.
BMC biotechnology 2006;6():28.
2005: Cheng Du; Wing C Chan; Timothy W McKeithan; Kenneth W Nickerson
Surface display of recombinant proteins on Bacillus thuringiensis spores.
Applied and environmental microbiology 2005;71(6):3337-41.
2005: Scott A Wetzel; Timothy W McKeithan; David Parker
Peptide-specific intercellular transfer of MHC class II to CD4+ T cells directly from the immunological synapse upon cellular dissociation.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(1):80-9.
2004: Beverly W Baron; John Anastasi; Anthony G Montag; Dezheng Huo; Rebecca M Baron; Theodore Karrison; Michael J Thirman; Sumit K Subudhi; Robert K Chin; Dean W Felsher; Yang-Xin Fu; Timothy W McKeithan; Joseph M Baron
The human BCL6 transgene promotes the development of lymphomas in the mouse.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(39):14198-203.
2004: Yulei Shen; Javeed Iqbal; Li Xiao; Ryan C Lynch; Andreas Rosenwald; Louis M Staudt; Simon Sherman; Karen Dybkaer; Guimei Zhou; James D Eudy; Jan Delabie; Timothy W McKeithan; Wing C Chan
Distinct gene expression profiles in different B-cell compartments in human peripheral lymphoid organs.
BMC immunology 2004;5():20.
2003: Baosheng Ge; Olga Li; Phillip J Wilder; Angie Rizzino; Timothy W McKeithan
NF-kappa B regulates BCL3 transcription in T lymphocytes through an intronic enhancer.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(8):4210-8.
2003: Zenggang Pan; Yulei Shen; Cheng Du; Guimei Zhou; Andreas Rosenwald; Louis M Staudt; Timothy C Greiner; Timothy W McKeithan; Wing C Chan
Two newly characterized germinal center B-cell-associated genes, GCET1 and GCET2, have differential expression in normal and neoplastic B cells.
The American journal of pathology 2003;163(1):135-44.
2003: Randall J Olsen; J Mazlo; Scott A Koepsell; Timothy W McKeithan; Steven H Hinrichs
Minimal structural elements of an inhibitory anti-ATF1/CREB single-chain antibody fragment (scFv41.4).
Hybridoma and hybridomics 2003;22(2):65-77.
2002: Scott A Wetzel; Timothy W McKeithan; David Parker
Live-cell dynamics and the role of costimulation in immunological synapse formation.
Journal of immunology (Baltimore, Md. : 1950) 2002;169(11):6092-101.
2002: Shantel Corbin; Mary E Neilly; Rafael Espinosa; Elizabeth M Davis; Timothy W McKeithan; Michelle M Le Beau
Identification of unstable sequences within the common fragile site at 3p14.2: implications for the mechanism of deletions within fragile histidine triad gene/common fragile site at 3p14.2 in tumors.
Cancer research 2002;62(12):3477-84.
2002: Beverly W Baron; John Anastasi; Michael J Thirman; Yoichi Furukawa; Scott C Fears; David C Kim; Federico Simone; Mark Birkenbach; Anthony G Montag; Annamma Sadhu; Nancy J Zeleznik-Le; Timothy W McKeithan
The human programmed cell death-2 (PDCD2) gene is a target of BCL6 repression: implications for a role of BCL6 in the down-regulation of apoptosis.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(5):2860-5.
1998: ST Ong; M L Hackbarth; LC Degenstein; DA Baunoch; John Anastasi; Timothy W McKeithan
Lymphadenopathy, splenomegaly, and altered immunoglobulin production in BCL3 transgenic mice.
Oncogene 1998;16(18):2333-43.
1998: Michelle M Le Beau; Harry A Drabkin; Thomas W Glover; Robert M Gemmill; Feyruz V Rassool; Timothy W McKeithan; David I Smith
An FHIT tumor suppressor gene?
Genes, chromosomes & cancer 1998;21(4):281-9.
1998: Michelle M Le Beau; Feyruz V Rassool; Mary E Neilly; Rafael Espinosa; Thomas W Glover; David I Smith; Timothy W McKeithan
Replication of a common fragile site, FRA3B, occurs late in S phase and is delayed further upon induction: implications for the mechanism of fragile site induction.
Human molecular genetics 1998;7(4):755-61.
1997: D L Bundy; Timothy W McKeithan
Diverse effects of BCL3 phosphorylation on its modulation of NF-kappaB p52 homodimer binding to DNA.
The Journal of biological chemistry 1997;272(52):33132-9.
1997: E A Shima-Rich; AM Harden; Timothy W McKeithan; Janet D Rowley; Manuel O Diaz
Molecular analysis of the t(8;14)(q24;q11) chromosomal breakpoint junctions in the T-cell leukemia line MOLT-16.
Genes, chromosomes & cancer 1997;20(4):363-71.
1997: Timothy W McKeithan; G S Takimoto; H Ohno; V S Bjorling; R Morgan; BK Hecht; I Dubé; A A Sandberg; Janet D Rowley
BCL3 rearrangements and t(14;19) in chronic lymphocytic leukemia and other B-cell malignancies: a molecular and cytogenetic study.
Genes, chromosomes & cancer 1997;20(1):64-72.
1997: ST Ong; Kwun M Fong; SA Bader; John D Minna; Michelle M Le Beau; Timothy W McKeithan; Feyruz V Rassool
Precise localization of the FHIT gene to the common fragile site at 3p14.2 (FRA3B) and characterization of homozygous deletions within FRA3B that affect FHIT transcription in tumor cell lines.
Genes, chromosomes & cancer 1997;20(1):16-23.
1997: Beverly W Baron; M Desai; L J Baber; L Paras; Q Zhang; Annamma Sadhu; SJ Duguay; Giuseppina Nucifora; Timothy W McKeithan; Nancy J Zeleznik-Le
BCL6 can repress transcription from the human immunodeficiency virus type I promoter/enhancer region.
Genes, chromosomes & cancer 1997;19(1):14-21.
1997: Annamma Sadhu; M L Shen; M Hackbarth; E Hume; Timothy W McKeithan
CpG-rich sequences close to the site of duplication within the human IGH constant region.
Immunogenetics 1997;45(6):365-70.
1996: Peter F Whitington; C M Rubin; Estella M Alonso; Timothy W McKeithan; J Anastasi; John Hart; J Richard Thistlethwaite
Complete lymphoid chimerism and chronic graft-versus-host disease in an infant recipient of a hepatic allograft from an HLA-homozygous parental living donor.
Transplantation 1996;62(10):1516-9.
1996: Feyruz V Rassool; Michelle M Le Beau; M L Shen; M E Neilly; Rafael Espinosa; ST Ong; F Boldog; Harry A Drabkin; R McCarroll; Timothy W McKeithan
Direct cloning of DNA sequences from the common fragile site region at chromosome band 3p14.2.
Genomics 1996;35(1):109-17.
1995: Timothy W McKeithan
Kinetic proofreading in T-cell receptor signal transduction.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(11):5042-6.
1995: Feyruz V Rassool; M E Neilly; K L McGuire; Timothy W McKeithan; Michelle M Le Beau
Localization of the Chinese hamster MHC locus to chromosome 1q17-->q18 by fluorescence in situ hybridization.
Cytogenetics and cell genetics 1995;71(1):62-3.
1994: Timothy W McKeithan; H Ohno; J Dickstein; E Hume
Genomic structure of the candidate proto-oncogene BCL3.
Genomics 1994;24(1):120-6.
1994: Q Zhang; J A Didonato; Michael Karin; Timothy W McKeithan
BCL3 encodes a nuclear protein which can alter the subcellular location of NF-kappa B proteins.
Molecular and cellular biology 1994;14(6):3915-26.
1993: Beverly W Baron; C Billstrand; L Madronero; Timothy W McKeithan
HindIII polymorphism in the BCL6 gene.
Human molecular genetics 1993;2(9):1513.
1993: D J Birn; Timothy W McKeithan; Giuseppina Nucifora
An EcoRI polymorphism in the AML1 gene.
Human molecular genetics 1993;2(7):1084.
1993: Beverly W Baron; Giuseppina Nucifora; N McCabe; Rafael Espinosa; Michelle M Le Beau; Timothy W McKeithan
Identification of the gene associated with the recurring chromosomal translocations t(3;14)(q27;q32) and t(3;22)(q27;q11) in B-cell lymphomas.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(11):5262-6.
1993: Giuseppina Nucifora; D J Birn; Rafael Espinosa; Paul F Erickson; M M LeBeau; Diane Roulston; Timothy W McKeithan; Harry A Drabkin; Janet D Rowley
Involvement of the AML1 gene in the t(3;21) in therapy-related leukemia and in chronic myeloid leukemia in blast crisis.
Blood 1993;81(10):2728-34.
1992: Timothy W McKeithan; L Warshawsky; Rafael Espinosa; M M LeBeau
Molecular cloning of the breakpoints of a complex Philadelphia chromosome translocation: identification of a repeated region on chromosome 17.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(11):4923-7.
1992: Feyruz V Rassool; Michelle M Le Beau; M E Neilly; E van Melle; Rafael Espinosa; Timothy W McKeithan
Increased genetic instability of the common fragile site at 3p14 after integration of exogenous DNA.
American journal of human genetics 1992;50(6):1243-51.
1992: E N Hatada; A Nieters; F G Wulczyn; M Naumann; R Meyer; Giuseppina Nucifora; Timothy W McKeithan; Claus Scheidereit
The ankyrin repeat domains of the NF-kappa B precursor p105 and the protooncogene bcl-3 act as specific inhibitors of NF-kappa B DNA binding.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(6):2489-93.
1992: Peter St George-Hyslop; H Ohno; James Gusella; Timothy W McKeithan
The BCL3 locus on chromosome 19 displays an informative microsatellite polymorphism.
Nucleic acids research 1992;20(4):927.
1991: Feyruz V Rassool; Timothy W McKeithan; M E Neilly; E van Melle; Rafael Espinosa; Michelle M Le Beau
Preferential integration of marker DNA into the chromosomal fragile site at 3p14: an approach to cloning fragile sites.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(15):6657-61.
1991: R Carter; Ian D Dubé; Timothy W McKeithan; K Carstairs; E DeHarven; D Bailey; J G Scott
Translocation (14;19) in acute biphenotypic leukemia.
Cancer genetics and cytogenetics 1991;53(1):67-73.
1991: A N Lorenzana; C M Rubin; Michelle M Le Beau; James B Nachman; P Connolly; U Subramanian; F L Johnson; Timothy W McKeithan
Immunoglobulin gene rearrangements in acute lymphoblastic leukemia with the 9;11 translocation.
Genes, chromosomes & cancer 1991;3(1):74-7.
1990: M Thangavelu; Olufunmilayo I Olopade; E Beckman; James W Vardiman; Richard A Larson; Timothy W McKeithan; Michelle M Le Beau; Janet D Rowley
Clinical, morphologic, and cytogenetic characteristics of patients with lymphoid malignancies characterized by both t(14;18)(q32;q21) and t(8;14)(q24;q32) or t(8;22)(q24;q11).
Genes, chromosomes & cancer 1990;2(2):147-58.
1990: M A Bitter; W A Franklin; Richard A Larson; Timothy W McKeithan; C M Rubin; Michelle M Le Beau; JK Stephens; James W Vardiman
Morphology in Ki-1(CD30)-positive non-Hodgkin's lymphoma is correlated with clinical features and the presence of a unique chromosomal abnormality, t(2;5)(p23;q35).
The American journal of surgical pathology 1990;14(4):305-16.
1990: H Ohno; G Takimoto; Timothy W McKeithan
The candidate proto-oncogene bcl-3 is related to genes implicated in cell lineage determination and cell cycle control.
Cell 1990;60(6):991-7.
1990: Timothy W McKeithan
Molecular biology of non-Hodgkin's lymphomas.
Seminars in oncology 1990;17(1):30-42.
1990: Timothy W McKeithan; H Ohno; Manuel O Diaz
Identification of a transcriptional unit adjacent to the breakpoint in the 14;19 translocation of chronic lymphocytic leukemia.
Genes, chromosomes & cancer 1990;1(3):247-55.
1989: J K Park; Timothy W McKeithan; Michelle M Le Beau; M A Bitter; W A Franklin; Janet D Rowley; Manuel O Diaz
An (8;14)(q24;q11) translocation involving the T-cell receptor alpha-chain gene and the MYC oncogene 3' region in a B-cell lymphoma.
Genes, chromosomes & cancer 1989;1(1):15-22.
1989: Ian D Dubé; J Dixon; T Beckett; A Grossman; M Weinstein; P Benn; Timothy W McKeithan; C Norman; Peter H Pinkerton
Location of breakpoints within the major breakpoint cluster region (bcr) in 33 patients with bcr rearrangement-positive chronic myeloid leukemia (CML) with complex or absent Philadelphia chromosomes.
Genes, chromosomes & cancer 1989;1(1):106-11.
1989: Timothy W McKeithan; H Ohno; J Rowley; M Diaz
Cloning of the breakpoint junction of the translocation 14;19 in chronic lymphocytic leukemia.
Haematology and blood transfusion 1989;32():335-6.
1987: Timothy W McKeithan; Janet D Rowley; TB Shows; Manuel O Diaz
Cloning of the chromosome translocation breakpoint junction of the t(14;19) in chronic lymphocytic leukemia.
Proceedings of the National Academy of Sciences of the United States of America 1987;84(24):9257-60.