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Steven McKenzie

Research Profile

Chemicals & Drugs

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Thrombocytopenia

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Publications

TOP 3
Huiying Zhi; Mortimer Poncz; Lubica Rauova; Brian Boylan; Brian C Cooley; Cunji Gao; Vincent Hayes; Steven E McKenzie; Debra K Newman; Peter J Newman
Cooperative integrin/ITAM signaling in platelets enhances thrombus formation in vitro and in vivo.
Steven E McKenzie
Monocytes in HIT: an evolving story.
Moritz Stolla; Pierrette André; Steven E McKenzie; Timothy D Ouellette; Michael P Reilly; Lucia Stefanini; Wolfgang Bergmeier
CalDAG-GEFI deficiency protects mice in a novel model of Fcγ RIIA-mediated thrombosis and thrombocytopenia.

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All Publications

2013: Huiying Zhi; Mortimer Poncz; Lubica Rauova; Brian Boylan; Brian C Cooley; Cunji Gao; Vincent Hayes; Steven E McKenzie; Debra K Newman; Peter J Newman
Cooperative integrin/ITAM signaling in platelets enhances thrombus formation in vitro and in vivo.
Blood 2013;121(10):1858-67.
2012: Steven E McKenzie
Monocytes in HIT: an evolving story.
Blood 2012;119(22):5065-6.
2011: Moritz Stolla; Pierrette André; Steven E McKenzie; Timothy D Ouellette; Michael P Reilly; Lucia Stefanini; Wolfgang Bergmeier
CalDAG-GEFI deficiency protects mice in a novel model of Fcγ RIIA-mediated thrombosis and thrombocytopenia.
Blood 2011;118(4):1113-20.
2011: Michael Reilly; Uma Sinha; Pierrette André; Scott M Taylor; Yvonne Pak; Francis R Deguzman; Nisha Nanda; Anjali Pandey; Moritz Stolla; Wolfgang Bergmeier; Steven E McKenzie
PRT-060318, a novel Syk inhibitor, prevents heparin-induced thrombocytopenia and thrombosis in a transgenic mouse model.
Blood 2011;117(7):2241-6.
2009: Lubica Rauova; Gowthami M Arepally; Steven E McKenzie; BA Konkle; Douglas B Cines; Mortimer Poncz
Platelet and monocyte antigenic complexes in the pathogenesis of heparin-induced thrombocytopenia (HIT).
Journal of thrombosis and haemostasis : JTH 2009;7 Suppl 1():249-52.
2007: Douglas B Cines; Lubica Rauova; Gowthami M Arepally; Michael Reilly; Steven E McKenzie; Bruce S Sachais; Mortimer Poncz
Heparin-induced thrombocytopenia: an autoimmune disorder regulated through dynamic autoantigen assembly/disassembly.
Journal of clinical apheresis 2007;22(1):31-6.
2007: Ming-Lin Liu; Michael Reilly; Peter Casasanto; Steven E McKenzie; Kevin Jon Williams
Cholesterol enrichment of human monocyte/macrophages induces surface exposure of phosphatidylserine and the release of biologically-active tissue factor-positive microvesicles.
Arteriosclerosis, thrombosis, and vascular biology 2007;27(2):430-5.
2006: Michael Reilly; Scott M Taylor; C Franklin; Bruce S Sachais; Douglas B Cines; Kevin Jon Williams; Steven E McKenzie
Prothrombotic factors enhance heparin-induced thrombocytopenia and thrombosis in vivo in a mouse model.
Journal of thrombosis and haemostasis : JTH 2006;4(12):2687-94.
2006: Randall G Worth; Christopher D Chien; Paul Chien; Michael Reilly; Steven E McKenzie; Alan D Schreiber
Platelet FcgammaRIIA binds and internalizes IgG-containing complexes.
Experimental hematology 2006;34(11):1490-5.
2005: Shayela Suvarna; Lubica Rauova; Emily K E McCracken; Christina M Goss; Bruce S Sachais; Steven E McKenzie; Michael Reilly; Michael Dee Gunn; Douglas B Cines; Mortimer Poncz; Gowthami M Arepally
PF4/heparin complexes are T cell-dependent antigens.
Blood 2005;106(3):929-31.
2005: Lubica Rauova; Mortimer Poncz; Steven E McKenzie; Michael Reilly; Gowthami M Arepally; John W Weisel; Chandrasekaran Nagaswami; Douglas B Cines; Bruce S Sachais
Ultralarge complexes of PF4 and heparin are central to the pathogenesis of heparin-induced thrombocytopenia.
Blood 2005;105(1):131-8.
2004: Steven E McKenzie; Michael Reilly
Heparin-induced thrombocytopenia and other immune thrombocytopenias: lessons from mouse models.
Seminars in thrombosis and hemostasis 2004;30(5):559-68.
2004: Mae M Coleman; Michael L Spear; Mark Finkelstein; Kathleen H Leef; Stephen A Pearlman; Christopher Chien; Scott M Taylor; Steven E McKenzie
Short-term use of umbilical artery catheters may not be associated with increased risk for thrombosis.
Pediatrics 2004;113(4):770-4.
2003: Douglas B Cines; Steven E McKenzie; Don L Siegel
Mechanisms of action of therapeutics in idiopathic thrombocytopenic purpura.
Journal of pediatric hematology/oncology 2003;25 Suppl 1():S52-6.
2003: Jack D Guida; Anette M Kunig; Kathleen H Leef; Steven E McKenzie; David A Paul
Platelet count and sepsis in very low birth weight neonates: is there an organism-specific response?
Pediatrics 2003;111(6 Pt 1):1411-5.
2002: Michael Reilly; Steven E McKenzie
Insights from mouse models of heparin-induced thrombocytopenia and thrombosis.
Current opinion in hematology 2002;9(5):395-400.
2002: Michael Reilly; Steven E McKenzie
Mechanisms of action of IVIg: physiology of Fc receptors.
Vox sanguinis 2002;83 Suppl 1():57-63.
2002: Hung-Ju Su; Saul Surrey; Steven E McKenzie; Paolo Fortina; David J Graves
Kinetics of heterogeneous hybridization on indium tin oxide surfaces with and without an applied potential.
Electrophoresis 2002;23(10):1551-7.
2002: Steven E McKenzie
Humanized mouse models of FcR clearance in immune platelet disorders.
Blood reviews 2002;16(1):3-5.
2001: Michael Reilly; Scott M Taylor; N K Hartman; Gowthami M Arepally; Bruce S Sachais; Douglas B Cines; Mortimer Poncz; Steven E McKenzie
Heparin-induced thrombocytopenia/thrombosis in a transgenic mouse model requires human platelet factor 4 and platelet activation through FcgammaRIIA.
Blood 2001;98(8):2442-7.
2001: Chunyan Zhang; Michael A Thornton; M Anna Kowalska; B S Sachis; M Feldman; Mortimer Poncz; Steven E McKenzie; Michael Reilly
Localization of distal regulatory domains in the megakaryocyte-specific platelet basic protein/platelet factor 4 gene locus.
Blood 2001;98(3):610-7.
2001: Karen W Gripp; Donna M McDonald-McGinn; D La Rossa; D McGain; Noah Federman; Adrianna Vlachos; Bertil E Glader; Steven E McKenzie; Jeffrey Lipton; Elaine H Zackai
Bilateral microtia and cleft palate in cousins with Diamond-Blackfan anemia.
American journal of medical genetics 2001;101(3):268-74.
2000: S M Taylor; Michael Reilly; Alan D Schreiber; Paul Chien; J R Tuckosh; Steven E McKenzie
Thrombosis and shock induced by activating antiplatelet antibodies in human Fc gamma RIIA transgenic mice: the interplay among antibody, spleen, and Fc receptor.
Blood 2000;96(13):4254-60.
2000: D L Cassel; S K Subudhi; Saul Surrey; Steven E McKenzie
GATA and NF-Y participate in transcriptional regulation of FcgammaRIIA in megakaryocytic cells.
Blood cells, molecules & diseases 2000;26(6):587-97.
2000: Elisabetta Manduchi; Gregory R Grant; Steven E McKenzie; GC Overton; Saul Surrey; Christian J Stoeckert
Generation of patterns from gene expression data by assigning confidence to differentially expressed genes.
Bioinformatics (Oxford, England) 2000;16(8):685-98.
1999: Steven E McKenzie; S M Taylor; P Malladi; H Yuhan; D L Cassel; Paul Chien; E Schwartz; Alan D Schreiber; Saul Surrey; Michael Reilly
The role of the human Fc receptor Fc gamma RIIA in the immune clearance of platelets: a transgenic mouse model.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(7):4311-8.
1998: David J Graves; H J Su; Steven E McKenzie; Saul Surrey; Paolo Fortina
System for preparing microhybridization arrays on glass slides.
Analytical chemistry 1998;70(23):5085-92.
1998: Steven E McKenzie; ES Mansfield; E Rappaport; Saul Surrey; Paolo Fortina
Parallel molecular genetic analysis.
European journal of human genetics : EJHG 1998;6(5):417-29.
1998: Z Cui; Michael Reilly; Saul Surrey; E Schwartz; Steven E McKenzie
-245 bp of 5'-flanking region from the human platelet factor 4 gene is sufficient to drive megakaryocyte-specific expression in vivo.
Blood 1998;91(7):2326-33.
1998: Cynthia F Norris; Luminita Pricop; S S Millard; S M Taylor; Saul Surrey; E Schwartz; Jane E Salmon; Steven E McKenzie
A naturally occurring mutation in Fc gamma RIIA: a Q to K127 change confers unique IgG binding properties to the R131 allelic form of the receptor.
Blood 1998;91(2):656-62.
1998: Steven E McKenzie; Alan D Schreiber
Fc gamma receptors in phagocytes.
Current opinion in hematology 1998;5(1):16-21.
1997: Gowthami M Arepally; Steven E McKenzie; X M Jiang; Mortimer Poncz; Douglas B Cines
Fc gamma RIIA H/R 131 polymorphism, subclass-specific IgG anti-heparin/platelet factor 4 antibodies and clinical course in patients with heparin-induced thrombocytopenia and thrombosis.
Blood 1997;89(2):370-5.
1996: X M Jiang; Gowthami M Arepally; Mortimer Poncz; Steven E McKenzie
Rapid detection of the Fc gamma RIIA-H/R 131 ligand-binding polymorphism using an allele-specific restriction enzyme digestion (ASRED).
Journal of immunological methods 1996;199(1):55-9.
1996: C Kiss; Saul Surrey; Alan D Schreiber; E Schwartz; Steven E McKenzie
Human c-kit ligand (stem cell factor) induces platelet Fc receptor expression in megakaryoblastic cells.
Experimental hematology 1996;24(10):1232-7.
1996: Karen D Fairchild; R G Hudson; Steven D Douglas; Steven E McKenzie; Richard A Polin
Effect of gamma interferon on expression of Fc gamma receptors in monocytes of newborn infants and adults.
Clinical and diagnostic laboratory immunology 1996;3(4):464-9.
1996: C F Norris; Saul Surrey; Greta R Bunin; E Schwartz; G R Buchanan; Steven E McKenzie
Relationship between Fc receptor IIA polymorphism and infection in children with sickle cell disease.
The Journal of pediatrics 1996;128(6):813-9.
1995: V Chan; D J Graves; Steven E McKenzie
The biophysics of DNA hybridization with immobilized oligonucleotide probes.
Biophysical journal 1995;69(6):2243-55.
1995: ES Mansfield; J M Worley; Steven E McKenzie; Saul Surrey; Eric F Rappaport; Paolo Fortina
Nucleic acid detection using non-radioactive labelling methods.
Molecular and cellular probes 1995;9(3):145-56.
1995: M A Keller; Steven E McKenzie; D L Cassel; Eric F Rappaport; E Schwartz; Saul Surrey
Lineage-specific alternative splicing of the human Fc gamma RIIA transmembrane exon requires sequences near the 3' splice site.
Gene expression 1995;4(4-5):217-25.
1994: A F Reilly; C F Norris; Saul Surrey; F J Bruchak; Eric F Rappaport; E Schwartz; Steven E McKenzie
Genetic diversity in human Fc receptor II for immunoglobulin G: Fc gamma receptor IIA ligand-binding polymorphism.
Clinical and diagnostic laboratory immunology 1994;1(6):640-4.
1994: Zena K Indik; X Q Pan; M M Huang; Steven E McKenzie; Arnold I Levinson; Alan D Schreiber
Insertion of cytoplasmic tyrosine sequences into the nonphagocytic receptor Fc gamma RIIB establishes phagocytic function.
Blood 1994;83(8):2072-80.
1994: A F Reilly; Saul Surrey; Eric F Rappaport; E Schwartz; Steven E McKenzie
Variation in human FCGR2C gene copy number.
Immunogenetics 1994;40(6):456.
1993: Robert Wasserman; Carolyn A Felix; Steven E McKenzie; S Shane; B Lange; L R Finger
Identification of an altered immunoglobulin heavy-chain gene rearrangement in the central nervous system in B-precursor acute lymphoblastic leukemia.
Leukemia 1993;7(8):1294-9.
1993: M A Keller; D L Cassel; Eric F Rappaport; Steven E McKenzie; E Schwartz; Saul Surrey
Fluorescence-based RT PCR analysis: determination of the ratio of soluble to membrane-bound forms of Fc gamma RIIA transcripts in hematopoietic cell lines.
PCR methods and applications 1993;3(1):32-8.
1993: Steven E McKenzie; J Kline; Steven D Douglas; Richard A Polin
Enhancement in vitro of the low interferon-gamma production of leukocytes from human newborn infants.
Journal of leukocyte biology 1993;53(6):691-6.
1993: Eric F Rappaport; D L Cassel; D O Walterhouse; Steven E McKenzie; Saul Surrey; M A Keller; Alan D Schreiber; E Schwartz
A soluble form of the human Fc receptor Fc gamma RIIA: cloning, transcript analysis and detection.
Experimental hematology 1993;21(5):689-96.
1993: D L Cassel; M A Keller; Saul Surrey; E Schwartz; Alan D Schreiber; Eric F Rappaport; Steven E McKenzie
Differential expression of Fc gamma RIIA, Fc gamma RIIB and Fc gamma RIIC in hematopoietic cells: analysis of transcripts.
Molecular immunology 1993;30(5):451-60.
1992: Steven E McKenzie; M A Keller; D L Cassel; Alan D Schreiber; E Schwartz; Saul Surrey; Eric F Rappaport
Characterization of the 5'-flanking transcriptional regulatory region of the human Fc gamma receptor gene, Fc gamma RIIA.
Molecular immunology 1992;29(10):1165-74.
1992: Zena K Indik; M Salehuddin; Steven E McKenzie; C Kelly; Arnold I Levinson; Alan D Schreiber
Human Fc gamma RII: the structure of the Fc gamma RII cytosolic domain governs phagocytic function.
Transactions of the Association of American Physicians 1992;105():214-21.