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Ruth McKernan

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John R Atack; D J Hallett; S Tye; Keith A Wafford; C Ryan; S M Sanabria-Bohórquez; Wai-Si Eng; R E Gibson; H Donald Burns; Gerard R Dawson; R W Carling; Leslie J Street; Andrew Pike; I De Lepeleire; K Van Laere; G Bormans; J N de Hoon; A Van Hecken; Ruth M McKernan; M G Murphy; Richard Hargreaves
Preclinical and clinical pharmacology of TPA023B, a GABAA receptor α2/α3 subtype-selective partial agonist.
John R Atack; Keith A Wafford; Leslie J Street; Gerard R Dawson; S Tye; K Van Laere; G Bormans; S M Sanabria-Bohórquez; I De Lepeleire; J N de Hoon; A Van Hecken; H D Burns; Ruth M McKernan; M G Murphy; Richard Hargreaves
MRK-409 (MK-0343), a GABAA receptor subtype-selective partial agonist, is a non-sedating anxiolytic in preclinical species but causes sedation in humans.
John R Atack; Dean F Wong; Tim D Fryer; Christine Ryan; Sandra Sanabria; Yun Zhou; Robert F Dannals; Wai-si Eng; Raymond E Gibson; H Donald Burns; Jose M Vega; Laura Vessy; Paul Scott-Stevens; John S Beech; Jean-Claude Baron; Bindi Sohal; Michael L Schrag; Franklin I Aigbirhio; Ruth M McKernan; Richard Hargreaves
Benzodiazepine binding site occupancy by the novel GABAA receptor subtype-selective drug 7-(1,1-dimethylethyl)-6-(2-ethyl-2H-1,2,4-triazol-3-ylmethoxy)-3-(2-fluorophenyl)-1,2,4-triazolo[4,3-b]pyridazine (TPA023) in rats, primates, and humans.

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All Publications

2011: John R Atack; D J Hallett; S Tye; Keith A Wafford; C Ryan; S M Sanabria-Bohórquez; Wai-Si Eng; R E Gibson; H Donald Burns; Gerard R Dawson; R W Carling; Leslie J Street; Andrew Pike; I De Lepeleire; K Van Laere; G Bormans; J N de Hoon; A Van Hecken; Ruth M McKernan; M G Murphy; Richard Hargreaves
Preclinical and clinical pharmacology of TPA023B, a GABAA receptor α2/α3 subtype-selective partial agonist.
Journal of psychopharmacology (Oxford, England) 2011;25(3):329-44.
2011: John R Atack; Keith A Wafford; Leslie J Street; Gerard R Dawson; S Tye; K Van Laere; G Bormans; S M Sanabria-Bohórquez; I De Lepeleire; J N de Hoon; A Van Hecken; H D Burns; Ruth M McKernan; M G Murphy; Richard Hargreaves
MRK-409 (MK-0343), a GABAA receptor subtype-selective partial agonist, is a non-sedating anxiolytic in preclinical species but causes sedation in humans.
Journal of psychopharmacology (Oxford, England) 2011;25(3):314-28.
2010: John R Atack; Dean F Wong; Tim D Fryer; Christine Ryan; Sandra Sanabria; Yun Zhou; Robert F Dannals; Wai-si Eng; Raymond E Gibson; H Donald Burns; Jose M Vega; Laura Vessy; Paul Scott-Stevens; John S Beech; Jean-Claude Baron; Bindi Sohal; Michael L Schrag; Franklin I Aigbirhio; Ruth M McKernan; Richard Hargreaves
Benzodiazepine binding site occupancy by the novel GABAA receptor subtype-selective drug 7-(1,1-dimethylethyl)-6-(2-ethyl-2H-1,2,4-triazol-3-ylmethoxy)-3-(2-fluorophenyl)-1,2,4-triazolo[4,3-b]pyridazine (TPA023) in rats, primates, and humans.
The Journal of pharmacology and experimental therapeutics 2010;332(1):17-25.
2007: Andrew Pike; Susan M Cook; Alan P Watt; Paul Scott-Stevens; Thomas W Rosahl; Ruth M McKernan; Luanda Pym; Alec Guiblin; Christopher Moyes; Bindi Sohal; John R Atack
Contribution of specific binding to the central benzodiazepine site to the brain concentrations of two novel benzodiazepine site ligands.
Biopharmaceutics & drug disposition 2007;28(6):275-82.
2007: John R Atack; Y Ohashi; Ruth M McKernan
Characterization of [35S]t-butylbicyclophosphorothionate ([35S]TBPS) binding to GABAA receptors in postmortem human brain.
British journal of pharmacology 2007;150(8):1066-74.
2006: John R Atack; Peter J Bayley; Guy R Seabrook; Keith A Wafford; Ruth M McKernan; Gerard R Dawson
L-655,708 enhances cognition in rats but is not proconvulsant at a dose selective for alpha5-containing GABAA receptors.
Neuropharmacology 2006;51(6):1023-9.
2006: John R Atack; Peter J Bayley; Stephen R Fletcher; Ruth M McKernan; Keith A Wafford; Gerard R Dawson
The proconvulsant effects of the GABAA alpha5 subtype-selective compound RY-080 may not be alpha5-mediated.
European journal of pharmacology 2006;548(1-3):77-82.
2006: John R Atack; Andrew Pike; Ashley Clarke; Susan M Cook; Bindi Sohal; Ruth M McKernan; Gerard R Dawson
Rat pharmacokinetics and pharmacodynamics of a sustained release formulation of the GABAA alpha5-selective compound L-655,708.
Drug metabolism and disposition: the biological fate of chemicals 2006;34(5):887-93.
2006: John R Atack; Andrew Pike; George Marshall; Joanna Stanley; Rachael Lincoln; Susan M Cook; Richard T Lewis; Wesley P Blackaby; Simon C Goodacre; Ruth M McKernan; Gerard R Dawson; Keith A Wafford; David S Reynolds
The in vivo properties of pagoclone in rat are most likely mediated by 5'-hydroxy pagoclone.
Neuropharmacology 2006;50(6):677-89.
2006: John R Atack; Keith A Wafford; Spencer J Tye; Susan M Cook; Bindi Sohal; Andrew Pike; Cyrille Sur; David Melillo; Linda J Bristow; Frances A Bromidge; Ian Ragan; Julie Kerby; Leslie J Street; Robert W Carling; José L Castro; Paul Whiting; Gerard R Dawson; Ruth M McKernan
TPA023 [7-(1,1-dimethylethyl)-6-(2-ethyl-2H-1,2,4-triazol-3-ylmethoxy)-3-(2-fluorophenyl)-1,2,4-triazolo[4,3-b]pyridazine], an agonist selective for alpha2- and alpha3-containing GABAA receptors, is a nonsedating anxiolytic in rodents and primates.
The Journal of pharmacology and experimental therapeutics 2006;316(1):410-22.
2005: Robert W Carling; Andrew Madin; Alec Guiblin; Michael G N Russell; Kevin W Moore; Andrew Mitchinson; Bindi Sohal; Andrew Pike; Susan M Cook; Ian C Ragan; Ruth M McKernan; Kathleen Quirk; Pushpinder Ferris; George Marshall; Sally-Anne Thompson; Keith A Wafford; Gerard R Dawson; John R Atack; Timothy Harrison; José L Castro; Leslie J Street
7-(1,1-Dimethylethyl)-6-(2-ethyl-2H-1,2,4-triazol-3-ylmethoxy)-3-(2-fluorophenyl)-1,2,4-triazolo[4,3-b]pyridazine: a functionally selective gamma-aminobutyric acid(A) (GABA(A)) alpha2/alpha3-subtype selective agonist that exhibits potent anxiolytic activity but is not sedating in animal models.
Journal of medicinal chemistry 2005;48(23):7089-92.
2005: Rebecca Dias; Wayne F A Sheppard; Rosa L Fradley; Elizabeth M Garrett; Joanna L Stanley; Spencer J Tye; Simon C Goodacre; Rachael Lincoln; Susan M Cook; Rachel Conley; David J Hallett; Alexander C Humphries; Sally-Anne Thompson; Keith A Wafford; Leslie J Street; José L Castro; Paul J Whiting; Thomas W Rosahl; John R Atack; Ruth M McKernan; Gerard R Dawson; David S Reynolds
Evidence for a significant role of alpha 3-containing GABAA receptors in mediating the anxiolytic effects of benzodiazepines.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2005;25(46):10682-8.
2005: Wesley P Blackaby; John R Atack; Frances A Bromidge; Richard Lewis; Michael G N Russell; Alison Smith; Keith A Wafford; Ruth M McKernan; Leslie J Street; José L Castro
Pyrazolopyridinones as functionally selective GABAA ligands.
Bioorganic & medicinal chemistry letters 2005;15(22):4998-5002.
2005: Luanda Pym; Susan M Cook; Thomas W Rosahl; Ruth M McKernan; John R Atack
Selective labelling of diazepam-insensitive GABAA receptors in vivo using [3H]Ro 15-4513.
British journal of pharmacology 2005;146(6):817-25.
2005: John R Atack; Luanda Alder; Susan M Cook; Alison J Smith; Ruth M McKernan
In vivo labelling of alpha5 subunit-containing GABA(A) receptors using the selective radioligand [(3)H]L-655,708.
Neuropharmacology 2005;49(2):220-9.
2005: Michael G N Russell; Robert W Carling; John R Atack; Frances A Bromidge; Susan M Cook; Peter Hunt; Catherine Isted; Matt Lucas; Ruth M McKernan; Andrew Mitchinson; Kevin W Moore; Robert Narquizian; Alison Macaulay; David Thomas; Sally-Anne Thompson; Keith A Wafford; José L Castro
Discovery of functionally selective 7,8,9,10-tetrahydro-7,10-ethano-1,2,4-triazolo[3,4-a]phthalazines as GABA A receptor agonists at the alpha3 subunit.
Journal of medicinal chemistry 2005;48(5):1367-83.
2005: John R Atack; Peter H Hutson; Neil Collinson; George Marshall; Graham Bentley; Christopher Moyes; Susan M Cook; Ian Collins; Keith A Wafford; Ruth M McKernan; Gerard R Dawson
Anxiogenic properties of an inverse agonist selective for alpha3 subunit-containing GABA A receptors.
British journal of pharmacology 2005;144(3):357-66.
2004: Andrew Mitchinson; John R Atack; Peter Blurton; Robert W Carling; José L Castro; Karen S Curley; Michael G N Russell; George Marshall; Ruth M McKernan; Kevin W Moore; Robert Narquizian; Alison Smith; Leslie J Street; Sally-Anne Thompson; Keith A Wafford
2,5-Dihydropyrazolo[4,3-c]pyridin-3-ones: functionally selective benzodiazepine binding site ligands on the GABAA receptor.
Bioorganic & medicinal chemistry letters 2004;14(13):3441-4.
2004: Leslie J Street; Francine Sternfeld; Richard A Jelley; Austin J Reeve; Robert W Carling; Kevin W Moore; Ruth M McKernan; Bindi Sohal; Susan Cook; Andrew Pike; Gerard R Dawson; Frances A Bromidge; Keith A Wafford; Guy R Seabrook; Sally-Anne Thompson; George Marshall; Gopalan V Pillai; José L Castro; John R Atack; Angus M MacLeod
Synthesis and biological evaluation of 3-heterocyclyl-7,8,9,10-tetrahydro-(7,10-ethano)-1,2,4-triazolo[3,4-a]phthalazines and analogues as subtype-selective inverse agonists for the GABA(A)alpha5 benzodiazepine binding site.
Journal of medicinal chemistry 2004;47(14):3642-57.
2004: Robert W Carling; Kevin W Moore; Leslie J Street; Deborah Wild; Catherine Isted; Paul D Leeson; Steven Thomas; desmond oconnor; Ruth M McKernan; Kathleen Quirk; Susan M Cook; John R Atack; Keith A Wafford; Sally-Anne Thompson; Gerard R Dawson; Pushpinder Ferris; José L Castro
3-phenyl-6-(2-pyridyl)methyloxy-1,2,4-triazolo[3,4-a]phthalazines and analogues: high-affinity gamma-aminobutyric acid-A benzodiazepine receptor ligands with alpha 2, alpha 3, and alpha 5-subtype binding selectivity over alpha 1.
Journal of medicinal chemistry 2004;47(7):1807-22.
2003: David S Reynolds; Thomas W Rosahl; Jennifer Cirone; Gillian F O'Meara; Alison Haythornthwaite; Richard J Newman; Janice Myers; Cyrille Sur; Owain Howell; A Richard Rutter; John R Atack; Alison Macaulay; Karen L Hadingham; Peter H Hutson; Delia Belelli; Jeremy J Lambert; Gerard R Dawson; Ruth M McKernan; Paul J Whiting; Keith A Wafford
Sedation and anesthesia mediated by distinct GABA(A) receptor isoforms.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2003;23(24):8608-17.
2002: Neil Collinson; Frederick M Kuenzi; Wolfgang Jarolimek; Karen A Maubach; Rosa Cothliff; Cyrille Sur; Alison Smith; Otu Franklin; Owain Howell; John R Atack; Ruth M McKernan; Guy R Seabrook; Gerard R Dawson; Paul J Whiting; Thomas W Rosahl
Enhanced learning and memory and altered GABAergic synaptic transmission in mice lacking the alpha 5 subunit of the GABAA receptor.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2002;22(13):5572-80.
2002: Ian Collins; Christopher Moyes; William B Davey; Michael Rowley; Frances A Bromidge; Kathleen Quirk; John R Atack; Ruth M McKernan; Sally-Anne Thompson; Keith A Wafford; Gerard R Dawson; Andrew Pike; Bindi Sohal; Nancy N Tsou; Richard G Ball; José L Castro
3-Heteroaryl-2-pyridones: benzodiazepine site ligands with functional delectivity for alpha 2/alpha 3-subtypes of human GABA(A) receptor-ion channels.
Journal of medicinal chemistry 2002;45(9):1887-900.
2001: Peter B Simpson; J I Bacha; E L Palfreyman; Anthony J Woollacott; Ruth M McKernan; Julie Kerby
Retinoic acid evoked-differentiation of neuroblastoma cells predominates over growth factor stimulation: an automated image capture and quantitation approach to neuritogenesis.
Analytical biochemistry 2001;298(2):163-9.
2001: C E Adkins; Gopalan V Pillai; Julie Kerby; Timothy P Bonnert; Christine Haldon; Ruth M McKernan; J E Gonzalez; K Oades; Paul J Whiting; Peter B Simpson
alpha4beta3delta GABA(A) receptors characterized by fluorescence resonance energy transfer-derived measurements of membrane potential.
The Journal of biological chemistry 2001;276(42):38934-9.
2001: David S Reynolds; Ruth M McKernan; Gerard R Dawson
Anxiolytic-like action of diazepam: which GABA(A) receptor subtype is involved?
Trends in pharmacological sciences 2001;22(8):402-3.
2001: Cyrille Sur; Keith A Wafford; David S Reynolds; Karen L Hadingham; Frances A Bromidge; Alison Macaulay; Neil Collinson; Gillian F O'Meara; Owain Howell; Robert Newman; Janice Myers; John R Atack; Gerard R Dawson; Ruth M McKernan; Paul J Whiting; Thomas W Rosahl
Loss of the major GABA(A) receptor subtype in the brain is not lethal in mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2001;21(10):3409-18.
2001: Alison J Smith; L Alder; Jonathan Silk; Charles H Adkins; A E Fletcher; T Scales; Julie Kerby; George Marshall; Keith A Wafford; Ruth M McKernan; John R Atack
Effect of alpha subunit on allosteric modulation of ion channel function in stably expressed human recombinant gamma-aminobutyric acid(A) receptors determined using (36)Cl ion flux.
Molecular pharmacology 2001;59(5):1108-18.
2001: Gordon Y K Ng; Sandrine Bertrand; R Sullivan; Nathalie Ethier; J Wang; James A Yergey; Michel Belley; Laird A Trimble; Kevin Bateman; L Alder; A Smith; Ruth M McKernan; Kathleen M Metters; Gary P O'Neill; Jean-Claude Lacaille; Terence E Hébert
Gamma-aminobutyric acid type B receptors with specific heterodimer composition and postsynaptic actions in hippocampal neurons are targets of anticonvulsant gabapentin action.
Molecular pharmacology 2001;59(1):144-52.
2000: Gerard R Dawson; Keith A Wafford; A Smith; G R Marshall; Peter J Bayley; J M Schaeffer; Peter T Meinke; Ruth M McKernan
Anticonvulsant and adverse effects of avermectin analogs in mice are mediated through the gamma-aminobutyric acid(A) receptor.
The Journal of pharmacology and experimental therapeutics 2000;295(3):1051-60.
2000: Ian Collins; William B Davey; Michael Rowley; Kathleen Quirk; Frances A Bromidge; Ruth M McKernan; Sally-Anne Thompson; Keith A Wafford
N-(indol-3-ylglyoxylyl)piperidines: high affinity agonists of human GABA-A receptors containing the alpha1 subunit.
Bioorganic & medicinal chemistry letters 2000;10(12):1381-4.
2000: Ruth M McKernan; Thomas W Rosahl; David S Reynolds; Cyrille Sur; Keith A Wafford; John R Atack; SJ Farrar; Janice Myers; G Cook; Pushpinder Ferris; L Garrett; Linda J Bristow; George Marshall; Alison Macaulay; Nicola Brown; Owain Howell; Kevin W Moore; Robert W Carling; Leslie J Street; José L Castro; C I Ragan; Gerard R Dawson; Paul J Whiting
Sedative but not anxiolytic properties of benzodiazepines are mediated by the GABA(A) receptor alpha1 subtype.
Nature neuroscience 2000;3(6):587-92.
2000: Giovambattista De Sarro; A Carotti; Francesco Campagna; Ruth M McKernan; M Rizzo; U Falconi; Fausta Palluotto; P Giusti; C Rettore; Angela De Sarro
Benzodiazepine receptor affinities, behavioral, and anticonvulsant activity of 2-aryl-2,5-dihydropyridazino[4,3-b]indol- 3(3H)-ones in mice.
Pharmacology, biochemistry, and behavior 2000;65(3):475-87.
2000: Owain Howell; John R Atack; D Dewar; Ruth M McKernan; Cyrille Sur
Density and pharmacology of alpha5 subunit-containing GABA(A) receptors are preserved in hippocampus of Alzheimer's disease patients.
Neuroscience 2000;98(4):669-75.
1999: Timothy P Bonnert; Ruth M McKernan; SJ Farrar; B Le Bourdellès; Robert P Heavens; DW Smith; Louise Hewson; MR Rigby; DJ Sirinathsinghji; Nicola Brown; Keith A Wafford; Paul J Whiting
theta, a novel gamma-aminobutyric acid type A receptor subunit.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(17):9891-6.
1999: Cyrille Sur; SJ Farrar; Julie Kerby; Paul J Whiting; John R Atack; Ruth M McKernan
Preferential coassembly of alpha4 and delta subunits of the gamma-aminobutyric acidA receptor in rat thalamus.
Molecular pharmacology 1999;56(1):110-5.
1999: Paul J Whiting; Timothy P Bonnert; Ruth M McKernan; SJ Farrar; B Le Bourdellès; Robert P Heavens; DW Smith; Louise Hewson; MR Rigby; DJ Sirinathsinghji; Sally-Anne Thompson; Keith A Wafford
Molecular and functional diversity of the expanding GABA-A receptor gene family.
Annals of the New York Academy of Sciences 1999;868():645-53.
1999: SJ Farrar; Paul J Whiting; Timothy P Bonnert; Ruth M McKernan
Stoichiometry of a ligand-gated ion channel determined by fluorescence energy transfer.
The Journal of biological chemistry 1999;274(15):10100-4.
1999: Cyrille Sur; L Fresu; Owain Howell; Ruth M McKernan; John R Atack
Autoradiographic localization of alpha5 subunit-containing GABAA receptors in rat brain.
Brain research 1999;822(1-2):265-70.
1999: John R Atack; A J Smith; F Emms; Ruth M McKernan
Regional differences in the inhibition of mouse in vivo [3H]Ro 15-1788 binding reflect selectivity for alpha 1 versus alpha 2 and alpha 3 subunit-containing GABAA receptors.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 1999;20(3):255-62.
1999: A J Smith; Ruth M McKernan
Proliferative effects of cholecystokinin in GH3 pituitary cells mediated by CCK2 receptors and potentiated by insulin.
British journal of pharmacology 1999;126(1):79-86.
1998: Cyrille Sur; Kathleen Quirk; D Dewar; John R Atack; Ruth M McKernan
Rat and human hippocampal alpha5 subunit-containing gamma-aminobutyric AcidA receptors have alpha5 beta3 gamma2 pharmacological characteristics.
Molecular pharmacology 1998;54(5):928-33.
1998: Ruth M McKernan; SJ Farrar; Ian Collins; F Emms; A Asuni; Kathleen Quirk; Howard B Broughton
Photoaffinity labeling of the benzodiazepine binding site of alpha1beta3gamma2 gamma-aminobutyric acidA receptors with flunitrazepam identifies a subset of ligands that interact directly with His102 of the alpha subunit and predicts orientation of these within the benzodiazepine pharmacophore.
Molecular pharmacology 1998;54(1):33-43.
1997: Giovambattista De Sarro; Alba Chimirri; Ruth M McKernan; Kathleen Quirk; P Giusti; Angela De Sarro
Anticonvulsant activity of azirino[1,2-d][1,4]benzodiazepines and related 1,4-benzodiazepines in mice.
Pharmacology, biochemistry, and behavior 1997;58(1):281-9.
1996: Sarah Grimwood; B Le Bourdellès; John R Atack; C Barton; W Cockett; S M Cook; E Gilbert; Peter H Hutson; Ruth M McKernan; J Myers; C Ian Ragan; Peter B Wingrove; Paul J Whiting
Generation and characterisation of stable cell lines expressing recombinant human N-methyl-D-aspartate receptor subtypes.
Journal of neurochemistry 1996;66(6):2239-47.
1996: Kathleen Quirk; P Blurton; S Fletcher; P Leeson; F Tang; D Mellilo; C Ian Ragan; Ruth M McKernan
[3H]L-655,708, a novel ligand selective for the benzodiazepine site of GABAA receptors which contain the alpha 5 subunit.
Neuropharmacology 1996;35(9-10):1331-5.
1995: Kathleen Quirk; Paul J Whiting; C Ian Ragan; Ruth M McKernan
Characterisation of delta-subunit containing GABAA receptors from rat brain.
European journal of pharmacology 1995;290(3):175-81.
1995: C Fernando Valenzuela; T K Machu; Ruth M McKernan; P Whiting; B B VanRenterghem; James L McManaman; SJ Brozowski; G B Smith; R W Olsen; R Adron Harris
Tyrosine kinase phosphorylation of GABAA receptors.
Brain research. Molecular brain research 1995;31(1-2):165-72.
1995: Ruth M McKernan; Keith A Wafford; Kathleen Quirk; Karen L Hadingham; E A Harley; C Ian Ragan; Paul J Whiting
The pharmacology of the benzodiazepine site of the GABA-A receptor is dependent on the type of gamma-subunit present.
Journal of receptor and signal transduction research 1995;15(1-4):173-83.
1995: Paul J Whiting; Ruth M McKernan; Keith A Wafford
Structure and pharmacology of vertebrate GABAA receptor subtypes.
International review of neurobiology 1995;38():95-138.
1994: John R Atack; A M Prior; S R Fletcher; Kathleen Quirk; Ruth M McKernan; C Ian Ragan
Effects of L-690,488, a prodrug of the bisphosphonate inositol monophosphatase inhibitor L-690,330, on phosphatidylinositol cycle markers.
The Journal of pharmacology and experimental therapeutics 1994;270(1):70-6.
1994: Kathleen Quirk; N P Gillard; C Ian Ragan; Paul J Whiting; Ruth M McKernan
Model of subunit composition of gamma-aminobutyric acid A receptor subtypes expressed in rat cerebellum with respect to their alpha and gamma/delta subunits.
The Journal of biological chemistry 1994;269(23):16020-8.
1994: Kathleen Quirk; N P Gillard; C Ian Ragan; Paul J Whiting; Ruth M McKernan
gamma-Aminobutyric acid type A receptors in the rat brain can contain both gamma 2 and gamma 3 subunits, but gamma 1 does not exist in combination with another gamma subunit.
Molecular pharmacology 1994;45(6):1061-70.
1994: Keith A Wafford; C J Bain; Kathleen Quirk; Ruth M McKernan; Peter B Wingrove; Paul J Whiting; J A Kemp
A novel allosteric modulatory site on the GABAA receptor beta subunit.
Neuron 1994;12(4):775-82.
1994: Kathleen Quirk; A C Foster; Ruth M McKernan
Characterization of the solubilized NMDA receptor complex from rat brain with [3H]L-689,560, a glycine site antagonist.
Molecular membrane biology 1994;11(1):17-21.
1993: C Ian Ragan; Ruth M McKernan; Keith A Wafford; Paul J Whiting
gamma-Aminobutyric acid-A (GABA-A) receptor/ion channel complex.
Biochemical Society transactions 1993;21 ( Pt 3)(3):622-6.
1992: Karen L Hadingham; P C Harkness; Ruth M McKernan; Kathleen Quirk; B Le Bourdellès; A L Horne; J A Kemp; E A Barnard; C Ian Ragan; Paul J Whiting
Stable expression of mammalian type A gamma-aminobutyric acid receptors in mouse cells: demonstration of functional assembly of benzodiazepine-responsive sites.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(14):6378-82.
1991: Ruth M McKernan; Kathleen Quirk; R Prince; P A Cox; N P Gillard; C Ian Ragan; P Whiting
GABAA receptor subtypes immunopurified from rat brain with alpha subunit-specific antibodies have unique pharmacological properties.
Neuron 1991;7(4):667-76.
1991: Ruth M McKernan; P Cox; N P Gillard; P Whiting
Differential expression of GABAA receptor alpha-subunits in rat brain during development.
FEBS letters 1991;286(1-2):44-6.
1991: M H Bakker; Ruth M McKernan; E H Wong; A C Foster
[3H]MK-801 binding to N-methyl-D-aspartate receptors solubilized from rat brain: effects of glycine site ligands, polyamines, ifenprodil, and desipramine.
Journal of neurochemistry 1991;57(1):39-45.
1991: N P Gillard; Kathleen Quirk; C Ian Ragan; Ruth M McKernan
[125I]iodoclonazepam, a specific high affinity radioligand for the identification of BZ1 and BZ2 sites in rat brain.
European journal of pharmacology 1991;195(3):407-9.
1990: P Whiting; Ruth M McKernan; L L Iversen
Another mechanism for creating diversity in gamma-aminobutyrate type A receptors: RNA splicing directs expression of two forms of gamma 2 phosphorylation site.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(24):9966-70.
1990: T Priestley; A L Horne; Ruth M McKernan; J A Kemp
The effect of NMDA receptor glycine site antagonists on hypoxia-induced neurodegeneration of rat cortical cell cultures.
Brain research 1990;531(1-2):183-8.
1990: Ruth M McKernan; N P Gillard; Kathleen Quirk; C O Kneen; GI Stevenson; Christopher J Swain; C Ian Ragan
Purification of the 5-hydroxytryptamine 5-HT3 receptor from NCB20 cells.
The Journal of biological chemistry 1990;265(23):13572-7.
1990: Ruth M McKernan; C S Biggs; N Gillard; Kathleen Quirk; C Ian Ragan
Molecular size of the 5-HT3 receptor solubilized from NCB 20 cells.
The Biochemical journal 1990;269(3):623-8.
1990: Ruth M McKernan; Kathleen Quirk; R G Jackson; C Ian Ragan
Solubilisation of the 5-hydroxytryptamine3 receptor from pooled rat cortical and hippocampal membranes.
Journal of neurochemistry 1990;54(3):924-30.
1989: Ruth M McKernan; S Castro; J A Poat; E H Wong
Solubilization of the N-methyl-D-aspartate receptor channel complex from rat and porcine brain.
Journal of neurochemistry 1989;52(3):777-85.