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James McKerrow

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

Research Profile (preview)

Chemicals & Drugs

Living Beings

Concepts & Ideas

Genes & Molecular Sequences

Amino Acid Sequence

Disorders

Schistosomiasis mansoni

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Publications

TOP 3
Bryant Clifford; Kerr Iain D; Debnath Moumita; Ang Kenny K H; Ratnam Joseline; Ferreira Rafaela S; Jaishankar Priyadarshini; Zhao DongMei; Arkin Michelle R; McKerrow James H; Brinen Linda S; Renslo Adam R
Novel non-peptidic vinylsulfones targeting the S2 and S3 subsites of parasite cysteine proteases.
Abodeely Marla; DuBois Kelly N; Hehl Adrian; Stefanic Sasa; Sajid Mohammed; DeSouza Wanderley; Attias Marcia; Engel Juan C; Hsieh Ivy; Fetter Richard D; McKerrow James H
A contiguous compartment functions as endoplasmic reticulum and endosome/lysosome in Giardia lamblia.
Mallari Jeremy P; Shelat Anang A; Kosinski Aaron; Caffrey Conor R; Connelly Michele; Zhu Fangyi; McKerrow James H; Guy R Kiplin
Structure-guided development of selective TbcatB inhibitors.

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All Publications

2009: Bryant Clifford; Kerr Iain D; Debnath Moumita; Ang Kenny K H; Ratnam Joseline; Ferreira Rafaela S; Jaishankar Priyadarshini; Zhao DongMei; Arkin Michelle R; McKerrow James H; Brinen Linda S; Renslo Adam R
Novel non-peptidic vinylsulfones targeting the S2 and S3 subsites of parasite cysteine proteases.
Bioorganic & medicinal chemistry letters 2009;19(21):6218-21.
2009: Abodeely Marla; DuBois Kelly N; Hehl Adrian; Stefanic Sasa; Sajid Mohammed; DeSouza Wanderley; Attias Marcia; Engel Juan C; Hsieh Ivy; Fetter Richard D; McKerrow James H
A contiguous compartment functions as endoplasmic reticulum and endosome/lysosome in Giardia lamblia.
Eukaryotic cell 2009;8(11):1665-76.
2009: Mallari Jeremy P; Shelat Anang A; Kosinski Aaron; Caffrey Conor R; Connelly Michele; Zhu Fangyi; McKerrow James H; Guy R Kiplin
Structure-guided development of selective TbcatB inhibitors.
Journal of medicinal chemistry 2009;52(20):6489-93.
2009: Kerr Iain D; Lee Ji H; Farady Christopher J; Marion Rachael; Rickert Mathias; Sajid Mohammed; Pandey Kailash C; Caffrey Conor R; Legac Jennifer; Hansell Elizabeth; McKerrow James H; Craik Charles S; Rosenthal Philip J; Brinen Linda S
Vinyl sulfones as antiparasitic agents and a structural basis for drug design.
The Journal of biological chemistry 2009;284(38):25697-703.
2009: McKerrow J H; Doyle P S; Engel J C; Podust L M; Robertson S A; Ferreira R; Saxton T; Arkin M; Kerr I D; Brinen L S; Craik C S
Two approaches to discovering and developing new drugs for Chagas disease.
Memórias do Instituto Oswaldo Cruz 2009;104 Suppl 1():263-9.
2009: Balsitis Scott J; Coloma Josefina; Castro Glenda; Alava Aracely; Flores Diana; McKerrow James H; Beatty P Robert; Harris Eva
Tropism of dengue virus in mice and humans defined by viral nonstructural protein 3-specific immunostaining.
The American journal of tropical medicine and hygiene 2009;80(3):416-24.
2009: Abdulla Maha-Hamadien; Ruelas Debbie S; Wolff Brian; Snedecor June; Lim Kee-Chong; Xu Fengyun; Renslo Adam R; Williams Janice; McKerrow James H; Caffrey Conor R
Drug discovery for schistosomiasis: hit and lead compounds identified in a library of known drugs by medium-throughput phenotypic screening.
PLoS neglected tropical diseases 2009;3(7):e478.
2009: Dvorák Jan; Mashiyama Susan T; Sajid Mohammed; Braschi Simon; Delcroix Melaine; Schneider Eric L; McKerrow Wilson H; Bahgat Mahmoud; Hansell Elizabeth; Babbitt Patricia C; Craik Charles S; McKerrow James H; Caffrey Conor R
SmCL3, a Gastrodermal Cysteine Protease of the Human Blood Fluke Schistosoma mansoni.
PLoS neglected tropical diseases 2009;3(6):e449.
2009: Caffrey Conor R; Rohwer Andreas; Oellien Frank; Marhöfer Richard J; Braschi Simon; Oliveira Guilherme; McKerrow James H; Selzer Paul M
A comparative chemogenomics strategy to predict potential drug targets in the metazoan pathogen, Schistosoma mansoni.
PloS one 2009;4(2):e4413.
2009: Chen Chiung-Kuang; Doyle Patricia S; Yermalitskaya Liudmila V; Mackey Zachary B; Ang Kenny K H; McKerrow James H; Podust Larissa M
Trypanosoma cruzi CYP51 Inhibitor Derived from a Mycobacterium tuberculosis Screen Hit.
PLoS neglected tropical diseases 2009;3(2):e372.
2008: McKerrow James H; Rosenthal Philip J; Swenerton Ryan; Doyle Patricia
Development of protease inhibitors for protozoan infections.
Current opinion in infectious diseases 2008;21(6):668-72.
2008: Chen Yen Ting; Lira Ricardo; Hansell Elizabeth; McKerrow James H; Roush William R
Synthesis of macrocyclic trypanosomal cysteine protease inhibitors.
Bioorganic & medicinal chemistry letters 2008;18(22):5860-3.
2008: O'Brien Theresa C; Mackey Zachary B; Fetter Richard D; Choe Youngchool; O'Donoghue Anthony J; Zhou Min; Craik Charles S; Caffrey Conor R; McKerrow James H
A parasite cysteine protease is key to host protein degradation and iron acquisition.
The Journal of biological chemistry 2008;283(43):28934-43.
2008: Fricker Simon P; Mosi Renee M; Cameron Beth R; Baird Ian; Zhu Youngbao; Anastassov Virginia; Cox Jennifer; Doyle Patricia S; Hansell Elizabeth; Lau Gloria; Langille Jonathan; Olsen Micki; Qin Ling; Skerlj Renato; Wong Rebecca S Y; Santucci Zefferino; McKerrow James H
Metal compounds for the treatment of parasitic diseases.
Journal of inorganic biochemistry 2008;102(10):1839-45.
2008: Kongkerd Natthawan; Uparanukraw Pichart; Morakote Nimit; Sajid Mohammed; McKerrow James H
Identification and characterization of a cathepsin L-like cysteine protease from Gnathostoma spinigerum.
Molecular and biochemical parasitology 2008;160(2):129-37.
2008: DuBois Kelly N; Abodeely Marla; Sakanari Judy; Craik Charles S; Lee Malinda; McKerrow James H; Sajid Mohammed
Identification of the major cysteine protease of Giardia and its role in encystation.
The Journal of biological chemistry 2008;283(26):18024-31.
2008: Brak Katrien; Doyle Patricia S; McKerrow James H; Ellman Jonathan A
Identification of a new class of nonpeptidic inhibitors of cruzain.
Journal of the American Chemical Society 2008;130(20):6404-10.
2008: Mallari Jeremy P; Shelat Anang; Kosinski Aaron; Caffrey Conor R; Connelly Michele; Zhu Fangyi; McKerrow James H; Guy R Kiplin
Discovery of trypanocidal thiosemicarbazone inhibitors of rhodesain and TbcatB.
Bioorganic & medicinal chemistry letters 2008;18(9):2883-5.
2008: Götz Marion G; James Karen Ellis; Hansell Elizabeth; Dvorák Jan; Seshaadri Amritha; Sojka Daniel; Kopácek Petr; McKerrow James H; Caffrey Conor R; Powers James C
Aza-peptidyl Michael acceptors. A new class of potent and selective inhibitors of asparaginyl endopeptidases (legumains) from evolutionarily diverse pathogens.
Journal of medicinal chemistry 2008;51(9):2816-32.
2008: Stack Colin M; Caffrey Conor R; Donnelly Sheila M; Seshaadri Amritha; Lowther Jonathan; Tort Jose F; Collins Peter R; Robinson Mark W; Xu Weibo; McKerrow James H; Craik Charles S; Geiger Sebastian R; Marion Rachel; Brinen Linda S; Dalton John P
Structural and functional relationships in the virulence-associated cathepsin L proteases of the parasitic liver fluke, Fasciola hepatica.
The Journal of biological chemistry 2008;283(15):9896-908.
2008: Mallari Jeremy P; Shelat Anang A; Obrien Terri; Caffrey Conor R; Kosinski Aaron; Connelly Michele; Harbut Michael; Greenbaum Doron; McKerrow James H; Guy R Kiplin
Development of potent purine-derived nitrile inhibitors of the trypanosomal protease TbcatB.
Journal of medicinal chemistry 2008;51(3):545-52.
2008: Dvorák Jan; Mashiyama Susan T; Braschi Simon; Sajid Mohammed; Knudsen Giselle M; Hansell Elizabeth; Lim Kee-Chong; Hsieh Ivy; Bahgat Mahmoud; Mackenzie Bryony; Medzihradszky Katalin F; Babbitt Patricia C; Caffrey Conor R; McKerrow James H
Differential use of protease families for invasion by schistosome cercariae.
Biochimie 2008;90(2):345-58.
2008: Jaishankar Priyadarshini; Hansell Elizabeth; Zhao Dong-Mei; Doyle Patricia S; McKerrow James H; Renslo Adam R
Potency and selectivity of P2/P3-modified inhibitors of cysteine proteases from trypanosomes.
Bioorganic & medicinal chemistry letters 2008;18(2):624-8.
2008: Aslam Akhmed; Quinn Phyllis; McIntosh Richard S; Shi Jianguo; Ghumra Ashfaq; McKerrow James H; Bunting Karen A; Dunne David W; Doenhoff Michael J; Morrison Sherie L; Zhang Ke; Pleass Richard J
Proteases from Schistosoma mansoni cercariae cleave IgE at solvent exposed interdomain regions.
Molecular immunology 2008;45(2):567-74.
2008: Abdulla Maha-Hamadien; O'Brien Theresa; Mackey Zachary B; Sajid Mohamed; Grab Dennis J; McKerrow James H
RNA Interference of Trypanosoma brucei Cathepsin B and L Affects Disease Progression in a Mouse Model.
PLoS neglected tropical diseases 2008;2(9):e298.
2008: Hansell Elizabeth; Braschi Simon; Medzihradszky Katalin F; Sajid Mohammed; Debnath Moumita; Ingram Jessica; Lim K C; McKerrow James H
Proteomic analysis of skin invasion by blood fluke larvae.
PLoS neglected tropical diseases 2008;2(7):e262.
2007: González Florenci V; Izquierdo Javier; Rodríguez Santiago; McKerrow James H; Hansell Elizabeth
Dipeptidyl-alpha,beta-epoxyesters as potent irreversible inhibitors of the cysteine proteases cruzain and rhodesain.
Bioorganic & medicinal chemistry letters 2007;17(24):6697-700.
2007: Davis Fred P; Barkan David T; Eswar Narayanan; McKerrow James H; Sali Andrej
Host pathogen protein interactions predicted by comparative modeling.
Protein science : a publication of the Protein Society 2007;16(12):2585-96.
2007: Doyle Patricia S; Zhou Yuan M; Engel Juan C; McKerrow James H
A cysteine protease inhibitor cures Chagas' disease in an immunodeficient-mouse model of infection.
Antimicrobial agents and chemotherapy 2007;51(11):3932-9.
2007: Kanaji Sachiko; Tanaka Yoko; Sakata Yasuhisa; Takeshita Kohei; Arima Kazuhiko; Ohta Shoichiro; Hansell Elizabeth J; Caffrey Conor; Mottram Jeremy C; Lowther Jonathan; Donnelly Sheila; Stack Colin; Kadowaki Tomoko; Yamamoto Kenji; McKerrow James H; Dalton John P; Coombs Graham H; Izuhara Kenji
Squamous cell carcinoma antigen 1 is an inhibitor of parasite-derived cysteine proteases.
FEBS letters 2007;581(22):4260-4.
2007: Goetz D H; Choe Y; Hansell E; Chen Y T; McDowell M; Jonsson C B; Roush W R; McKerrow J; Craik C S
Substrate specificity profiling and identification of a new class of inhibitor for the major protease of the SARS coronavirus.
Biochemistry 2007;46(30):8744-52.
2007: Meléndez-López Samuel G; Herdman Scott; Hirata Ken; Choi Min-Ho; Choe Youngchool; Craik Charles; Caffrey Conor R; Hansell Elisabeth; Chávez-Munguía Bibiana; Chen Yen Ting; Roush William R; McKerrow James; Eckmann Lars; Guo Jianhua; Stanley Samuel L; Reed Sharon L
Use of recombinant Entamoeba histolytica cysteine proteinase 1 to identify a potent inhibitor of amebic invasion in a human colonic model.
Eukaryotic cell 2007;6(7):1130-6.
2007: Delcroix Melaine; Medzihradsky Katalin; Caffrey Conor R; Fetter Richard D; McKerrow James H
Proteomic analysis of adult S. mansoni gut contents.
Molecular and biochemical parasitology 2007;154(1):95-7.
2007: Debnath Anjan; Tashker Jessica S; Sajid Mohammed; McKerrow James H
Transcriptional and secretory responses of Entamoeba histolytica to mucins, epithelial cells and bacteria.
International journal for parasitology 2007;37(8-9):897-906.
2007: Caffrey Conor R; Steverding Dietmar; Swenerton Ryan K; Kelly Ben; Walshe Deirdre; Debnath Anjan; Zhou Yuan-Min; Doyle Patricia S; Fafarman Aaron T; Zorn Julie A; Land Kirkwood M; Beauchene Jessica; Schreiber Kimberly; Moll Heidrun; Ponte-Sucre Alicia; Schirmeister Tanja; Saravanamuthu Ahilan; Fairlamb Alan H; Cohen Fred E; McKerrow James H; Weisman Jennifer L; May Barnaby C H
Bis-acridines as lead antiparasitic agents: structure-activity analysis of a discrete compound library in vitro.
Antimicrobial agents and chemotherapy 2007;51(6):2164-72.
2007: Sojka Daniel; Hajdusek Ondrej; Dvorák Jan; Sajid Mohammed; Franta Zdenek; Schneider Eric L; Craik Charles S; Vancová Marie; Buresová Veronika; Bogyo Matthew; Sexton Kelly B; McKerrow James H; Caffrey Conor R; Kopácek Petr
IrAE: an asparaginyl endopeptidase (legumain) in the gut of the hard tick Ixodes ricinus.
International journal for parasitology 2007;37(7):713-24.
2007: Wang Stephanie X; Pandey Kailash C; Scharfstein Julio; Whisstock James; Huang Rick K; Jacobelli Jordan; Fletterick Robert J; Rosenthal Philip J; Abrahamson Magnus; Brinen Linda S; Rossi Andrea; Sali Andrej; McKerrow James H
The structure of chagasin in complex with a cysteine protease clarifies the binding mode and evolution of an inhibitor family.
Structure (London, England : 1993) 2007;15(5):535-43.
2007: Hirata Ken K; Que Xuchu; Melendez-Lopez Samuel G; Debnath Anjan; Myers Simona; Herdman D Scott; Orozco Esther; Bhattacharya Alok; McKerrow James H; Reed Sharon L
A phagocytosis mutant of Entamoeba histolytica is less virulent due to deficient proteinase expression and release.
Experimental parasitology 2007;115(2):192-9.
2007: Abdulla Maha-Hamadien; Lim Kee-Chong; Sajid Mohammed; McKerrow James H; Caffrey Conor R
Schistosomiasis mansoni: novel chemotherapy using a cysteine protease inhibitor.
PLoS medicine 2007;4(1):e14.
2007: Jolly Emmitt R; Chin Chen-Shan; Miller Steve; Bahgat Mahmoud M; Lim K C; DeRisi Joseph; McKerrow James H
Gene expression patterns during adaptation of a helminth parasite to different environmental niches.
Genome biology 2007;8(4):R65.
2006: Renslo Adam R; McKerrow James H
Drug discovery and development for neglected parasitic diseases.
Nature chemical biology 2006;2(12):701-10.
2006: Blank Rebecca B; Lamb Erika W; Tocheva Anna S; Crow Emily T; Lim K C; McKerrow James H; Davies Stephen J
The common gamma chain cytokines interleukin (IL)-2 and IL-7 indirectly modulate blood fluke development via effects on CD4+ T cells.
The Journal of infectious diseases 2006;194(11):1609-16.
2006: Delcroix Melaine; Sajid Mohammed; Caffrey Conor R; Lim Kee-C; Dvorák Jan; Hsieh Ivy; Bahgat Mahmoud; Dissous Colette; McKerrow James H
A multienzyme network functions in intestinal protein digestion by a platyhelminth parasite.
The Journal of biological chemistry 2006;281(51):39316-29.
2006: McIntosh R S; Jones F M; Dunne D W; McKerrow J H; Pleass R J
Characterization of immunoglobulin binding by schistosomes.
Parasite immunology 2006;28(9):407-19.
2006: DuBois Kelly N; Abodeely Marla; Sajid Mohammed; Engel Juan C; McKerrow James H
Giardia lamblia cysteine proteases.
Parasitology research 2006;99(4):313-6.
2006: Beckham Simone A; Law Ruby H-P; Smooker Peter M; Quinsey Noelene S; Caffrey Conor R; McKerrow James H; Pike Robert N; Spithill Terry W
Production and processing of a recombinant Fasciola hepatica cathepsin B-like enzyme (FhcatB1) reveals potential processing mechanisms in the parasite.
Biological chemistry 2006;387(8):1053-61.
2006: Wang Stephanie X; Pandey Kailash C; Somoza John R; Sijwali Puran S; Kortemme Tanja; Brinen Linda S; Fletterick Robert J; Rosenthal Philip J; McKerrow James H
Structural basis for unique mechanisms of folding and hemoglobin binding by a malarial protease.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(31):11503-8.
2006: Mackey Zachary B; Baca Arthur M; Mallari Jeremy P; Apsel Beth; Shelat Anang; Hansell Elizabeth J; Chiang Peter K; Wolff Brian; Guy Kiplin R; Williams Janice; McKerrow James H
Discovery of trypanocidal compounds by whole cell HTS of Trypanosoma brucei.
Chemical biology & drug design 2006;67(5):355-63.
2006: Vicik Radim; Hoerr Verena; Glaser Melanie; Schultheis Martina; Hansell Elizabeth; McKerrow James H; Holzgrabe Ulrike; Caffrey Conor R; Ponte-Sucre Alicia; Moll Heidrun; Stich August; Schirmeister Tanja
Aziridine-2,3-dicarboxylate inhibitors targeting the major cysteine protease of Trypanosoma brucei as lead trypanocidal agents.
Bioorganic & medicinal chemistry letters 2006;16(10):2753-7.
2006: Rapp Magdalena; Haubrich Trisha A; Perrault Jacques; Mackey Zachary B; McKerrow James H; Chiang Peter K; Wnuk Stanislaw F
Antitrypanosomal activity of 5'-deoxy-5'-(iodomethylene)adenosine and related 6-N-cyclopropyladenosine analogues.
Journal of medicinal chemistry 2006;49(6):2096-102.
2006: McKerrow James H; Caffrey Conor; Kelly Ben; Loke P'ng; Sajid Mohammed
Proteases in parasitic diseases.
Annual review of pathology 2006;1():497-536.
2005: Barr S C; Warner K L; Kornreic B G; Piscitelli J; Wolfe A; Benet L; McKerrow J H
A cysteine protease inhibitor protects dogs from cardiac damage during infection by Trypanosoma cruzi.
Antimicrobial agents and chemotherapy 2005;49(12):5160-1.
2005: Knudsen Giselle M; Medzihradszky Katalin F; Lim Kee-Chong; Hansell Elizabeth; McKerrow James H
Proteomic analysis of Schistosoma mansoni cercarial secretions.
Molecular & cellular proteomics : MCP 2005;4(12):1862-75.
2005: McKerrow James H
Designing drugs for parasitic diseases of the developing world.
PLoS medicine 2005;2(8):e210.
2005: Dvorák Jan; Delcroix Melaine; Rossi Andrea; Vopálenský Václav; Pospísek Martin; Sedinová Miroslava; Mikes Libor; Sajid Mohammed; Sali Andrej; McKerrow James H; Horák Petr; Caffrey Conor R
Multiple cathepsin B isoforms in schistosomula of Trichobilharzia regenti: identification, characterisation and putative role in migration and nutrition.
International journal for parasitology 2005;35(8):895-910.
2005: Davies Stephen J; Smith Steven J; Lim K C; Zhang Hongbing; Purchio Anthony F; McKerrow James H; West David B
In vivo imaging of tissue eosinophilia and eosinopoietic responses to schistosome worms and eggs.
International journal for parasitology 2005;35(8):851-9.
2005: Pandey Kailash C; Wang Stephanie X; Sijwali Puran S; Lau Anthony L; McKerrow James H; Rosenthal Philip J
The Plasmodium falciparum cysteine protease falcipain-2 captures its substrate, hemoglobin, via a unique motif.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(26):9138-43.
2005: Wippersteg Volker; Sajid Mohammed; Walshe Deirdre; Khiem Dustin; Salter Jason P; McKerrow James H; Grevelding Christoph G; Caffrey Conor R
Biolistic transformation of Schistosoma mansoni with 5' flanking regions of two peptidase genes promotes tissue-specific expression.
International journal for parasitology 2005;35(6):583-9.
2005: Caffrey Conor R; Placha Lenka; Barinka Cyril; Hradilek Martin; Dostál Jirí; Sajid Mohammed; McKerrow James H; Majer Pavel; Konvalinka Jan; Vondrásek Jirí
Homology modeling and SAR analysis of Schistosoma japonicum cathepsin D (SjCD) with statin inhibitors identify a unique active site steric barrier with potential for the design of specific inhibitors.
Biological chemistry 2005;386(4):339-49.
2005: Fujii Naoaki; Mallari Jeremy P; Hansell Elizabeth J; Mackey Z; Doyle Patricia; Zhou Y M; Gut Jiri; Rosenthal Philip J; McKerrow James H; Guy R Kiplin
Discovery of potent thiosemicarbazone inhibitors of rhodesain and cruzain.
Bioorganic & medicinal chemistry letters 2005;15(1):121-3.
2004: Mackey Zachary B; O'Brien Theresa C; Greenbaum Doron C; Blank Rebecca B; McKerrow James H
A cathepsin B-like protease is required for host protein degradation in Trypanosoma brucei.
The Journal of biological chemistry 2004;279(46):48426-33.
2004: Götz Marion G; Caffrey Conor R; Hansell Elizabeth; McKerrow James H; Powers James C
Peptidyl allyl sulfones: a new class of inhibitors for clan CA cysteine proteases.
Bioorganic & medicinal chemistry 2004;12(19):5203-11.
2004: Kaviratne Mallika; Hesse Matthias; Leusink Mary; Cheever Allen W; Davies Stephen J; McKerrow James H; Wakefield Lalage M; Letterio John J; Wynn Thomas A
IL-13 activates a mechanism of tissue fibrosis that is completely TGF-beta independent.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(6):4020-9.
2004: Guiliano David B; Hong Xiqiang; McKerrow James H; Blaxter Mark L; Oksov Yelena; Liu Jing; Ghedin Elodie; Lustigman Sara
A gene family of cathepsin L-like proteases of filarial nematodes are associated with larval molting and cuticle and eggshell remodeling.
Molecular and biochemical parasitology 2004;136(2):227-42.
2004: Debnath Anjan; Das Pradeep; Sajid Mohammed; McKerrow James H
Identification of genomic responses to collagen binding by trophozoites of Entamoeba histolytica.
The Journal of infectious diseases 2004;190(3):448-57.
2004: Williamson Angela L; Lecchi Paolo; Turk Benjamin E; Choe Youngchool; Hotez Peter J; McKerrow James H; Cantley Lewis C; Sajid Mohammed; Craik Charles S; Loukas Alex
A multi-enzyme cascade of hemoglobin proteolysis in the intestine of blood-feeding hookworms.
The Journal of biological chemistry 2004;279(34):35950-7.
2004: Greenbaum Doron C; Mackey Zachary; Hansell Elizabeth; Doyle Patricia; Gut Jiri; Caffrey Conor R; Lehrman Julia; Rosenthal Philip J; McKerrow James H; Chibale Kelly
Synthesis and structure-activity relationships of parasiticidal thiosemicarbazone cysteine protease inhibitors against Plasmodium falciparum, Trypanosoma brucei, and Trypanosoma cruzi.
Journal of medicinal chemistry 2004;47(12):3212-9.
2004: Caffrey Conor R; McKerrow James H; Salter Jason P; Sajid Mohammed
Blood 'n' guts: an update on schistosome digestive peptidases.
Trends in parasitology 2004;20(5):241-8.
2004: Ekici Ozlem Dogan; Götz Marion G; James Karen Ellis; Li Zhao Zhao; Rukamp Brian J; Asgian Juliana L; Caffrey Conor R; Hansell Elizabeth; Dvorák Jan; McKerrow James H; Potempa Jan; Travis James; Mikolajczyk Jowita; Salvesen Guy S; Powers James C
Aza-peptide Michael acceptors: a new class of inhibitors specific for caspases and other clan CD cysteine proteases.
Journal of medicinal chemistry 2004;47(8):1889-92.
2004: Mahmoudzadeh-Niknam H; McKerrow J H
Leishmania tropica: cysteine proteases are essential for growth and pathogenicity.
Experimental parasitology 2004;106(3-4):158-63.
2004: Hernandez David C; Lim K C; McKerrow James H; Davies Stephen J
Schistosoma mansoni: sex-specific modulation of parasite growth by host immune signals.
Experimental parasitology 2004;106(1-2):59-61.
2004: Davies Stephen J; Lim K C; Blank Rebecca B; Kim Jea-Hyoun; Lucas Kimberley D; Hernandez David C; Sedgwick Jonathon D; McKerrow James H
Involvement of TNF in limiting liver pathology and promoting parasite survival during schistosome infection.
International journal for parasitology 2004;34(1):27-36.
2003: James Karen Ellis; Götz Marion G; Caffrey Conor R; Hansell Elizabeth; Carter Wendy; Barrett Alan J; McKerrow James H; Powers James C
Aza-peptide epoxides: potent and selective inhibitors of Schistosoma mansoni and pig kidney legumains (asparaginyl endopeptidases).
Biological chemistry 2003;384(12):1613-8.
2003: Chiyanzu Idan; Hansell Elizabeth; Gut Jiri; Rosenthal Philip J; McKerrow James H; Chibale Kelly
Synthesis and evaluation of isatins and thiosemicarbazone derivatives against cruzain, falcipain-2 and rhodesain.
Bioorganic & medicinal chemistry letters 2003;13(20):3527-30.
2003: Davies Stephen J; McKerrow James H
Developmental plasticity in schistosomes and other helminths.
International journal for parasitology 2003;33(11):1277-84.
2003: Sajid Mohammed; McKerrow James H; Hansell Elizabeth; Mathieu Mary A; Lucas Kimberley D; Hsieh Ivy; Greenbaum Doron; Bogyo Matthew; Salter Jason P; Lim Kee C; Franklin Christopher; Kim Jea-Hyoun; Caffrey Conor R
Functional expression and characterization of Schistosoma mansoni cathepsin B and its trans-activation by an endogenous asparaginyl endopeptidase.
Molecular and biochemical parasitology 2003;131(1):65-75.
2003: Nkemgu Njinkeng Joseph; Grande Rachel; Hansell Elizabeth; McKerrow James H; Caffrey Conor R; Steverding Dietmar
Improved trypanocidal activities of cathepsin L inhibitors.
International journal of antimicrobial agents 2003;22(2):155-9.
2003: Que Xuchu; Kim Soo-Hyun; Sajid Mohammed; Eckmann Lars; Dinarello Charles A; McKerrow James H; Reed Sharon L
A surface amebic cysteine proteinase inactivates interleukin-18.
Infection and immunity 2003;71(3):1274-80.
2003: Bok R A; Hansell E J; Nguyen T P; Greenberg N M; McKerrow J H; Shuman M A
Patterns of protease production during prostate cancer progression: proteomic evidence for cascades in a transgenic model.
Prostate cancer and prostatic diseases 2003;6(4):272-80.
2002: Salter Jason P; Choe Youngchool; Albrecht Hugo; Franklin Christopher; Lim Kee-Chong; Craik Charles S; McKerrow James H
Cercarial elastase is encoded by a functionally conserved gene family across multiple species of schistosomes.
The Journal of biological chemistry 2002;277(27):24618-24.
2002: Du Xiaohui; Guo Chun; Hansell Elizabeth; Doyle Patricia S; Caffrey Conor R; Holler Tod P; McKerrow James H; Cohen Fred E
Synthesis and structure-activity relationship study of potent trypanocidal thio semicarbazone inhibitors of the trypanosomal cysteine protease cruzain.
Journal of medicinal chemistry 2002;45(13):2695-707.
2002: Rodrigues Carlos R; Flaherty Terrence M; Springer Clayton; McKerrow James H; Cohen Fred E
CoMFA and HQSAR of acylhydrazide cruzain inhibitors.
Bioorganic & medicinal chemistry letters 2002;12(11):1537-41.
2002: McKerrow James H; Salter Jason
Invasion of skin by Schistosoma cercariae.
Trends in parasitology 2002;18(5):193-5.
2002: Mathieu Mary A; Bogyo Matthew; Caffrey Conor R; Choe Youngchool; Lee Jewok; Chapman Harold; Sajid Mohammed; Craik Charles S; McKerrow James H
Substrate specificity of schistosome versus human legumain determined by P1-P3 peptide libraries.
Molecular and biochemical parasitology 2002;121(1):99-105.
2002: Caffrey Conor R; Salter Jason P; Lucas Kimberley D; Khiem Dustin; Hsieh Ivy; Lim Kee-Chong; Ruppel Andreas; McKerrow James H; Sajid Mohammed
SmCB2, a novel tegumental cathepsin B from adult Schistosoma mansoni.
Molecular and biochemical parasitology 2002;121(1):49-61.
2002: Caffrey Conor R; Schanz Marvin; Nkemngu Njinkeng Joseph; Brush Matthew; Hansell Elizabeth; Cohen Fred E; Flaherty Terrence M; McKerrow James H; Steverding Dietmar
Screening of acyl hydrazide proteinase inhibitors for antiparasitic activity against Trypanosoma brucei.
International journal of antimicrobial agents 2002;19(3):227-31.
2002: Sajid M; McKerrow J H
Cysteine proteases of parasitic organisms.
Molecular and biochemical parasitology 2002;120(1):1-21.
2002: Que Xuchu; Brinen Linda S; Perkins Penny; Herdman Scott; Hirata Ken; Torian Bruce E; Rubin Harvey; McKerrow James H; Reed Sharon L
Cysteine proteinases from distinct cellular compartments are recruited to phagocytic vesicles by Entamoeba histolytica.
Molecular and biochemical parasitology 2002;119(1):23-32.
2001: Caffrey C R; Hansell E; Lucas K D; Brinen L S; Alvarez Hernandez A; Cheng J; Gwaltney S L; Roush W R; Stierhof Y D; Bogyo M; Steverding D; McKerrow J H
Active site mapping, biochemical properties and subcellular localization of rhodesain, the major cysteine protease of Trypanosoma brucei rhodesiense.
Molecular and biochemical parasitology 2001;118(1):61-73.
2001: Davies S J; Grogan J L; Blank R B; Lim K C; Locksley R M; McKerrow J H
Modulation of blood fluke development in the liver by hepatic CD4+ lymphocytes.
Science (New York, N.Y.) 2001;294(5545):1358-61.
2001: Lecaille F; Cotton J; McKerrow J H; Ferrer-Di Martino M; Boll-Bataillé E; Gauthier F; Lalmanach G
Reversible inhibition of cathepsin L-like proteases by 4-mer pseudopeptides.
FEBS letters 2001;507(3):362-6.
2001: Roush W R; Cheng J; Knapp-Reed B; Alvarez-Hernandez A; McKerrow J H; Hansell E; Engel J C
Potent second generation vinyl sulfonamide inhibitors of the trypanosomal cysteine protease cruzain.
Bioorganic & medicinal chemistry letters 2001;11(20):2759-62.
2001: Paddock C D; McKerrow J H; Hansell E; Foreman K W; Hsieh I; Marshall N
Identification, cloning, and recombinant expression of procalin, a major triatomine allergen.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(5):2694-9.
2000: Salter J P; Lim K C; Hansell E; Hsieh I; McKerrow J H
Schistosome invasion of human skin and degradation of dermal elastin are mediated by a single serine protease.
The Journal of biological chemistry 2000;275(49):38667-73.
2000: Du X; Hansell E; Engel J C; Caffrey C R; Cohen F E; McKerrow J H
Aryl ureas represent a new class of anti-trypanosomal agents.
Chemistry & biology 2000;7(9):733-42.
2000: Troeberg L; Chen X; Flaherty T M; Morty R E; Cheng M; Hua H; Springer C; McKerrow J H; Kenyon G L; Lonsdale-Eccles J D; Coetzer T H; Cohen F E
Chalcone, acyl hydrazide, and related amides kill cultured Trypanosoma brucei brucei.
Molecular medicine (Cambridge, Mass.) 2000;6(8):660-9.
2000: Brinen L S; Hansell E; Cheng J; Roush W R; McKerrow J H; Fletterick R J
A target within the target: probing cruzain's P1' site to define structural determinants for the Chagas' disease protease.
Structure (London, England : 1993) 2000;8(8):831-40.
2000: Brinen L S; Que X; McKerrow J H; Reed S L
Homology modeling of Entamoeba histolytica cysteine proteinases reveals the basis for cathepsin L-like structure with cathepsin B-like specificity.
Archives of medical research 2000;31(4 Suppl):S63-4.
2000: McKerrow J H; Bhargava V; Hansell E; Huling S; Kuwahara T; Matley M; Coussens L; Warren R
A functional proteomics screen of proteases in colorectal carcinoma.
Molecular medicine (Cambridge, Mass.) 2000;6(5):450-60.
2000: Engel J C; Torres C; Hsieh I; Doyle P S; McKerrow J H;
Upregulation of the secretory pathway in cysteine protease inhibitor-resistant Trypanosoma cruzi.
Journal of cell science 2000;113 ( Pt 8)():1345-54.
2000: Stoka V; Turk B; McKerrow J H; Björk I; Cazzulo J J; Turk V
The high stability of cruzipain against pH-induced inactivation is not dependent on its C-terminal domain.
FEBS letters 2000;469(1):29-32.
2000: Caffrey C R; Mathieu M A; Gaffney A M; Salter J P; Sajid M; Lucas K D; Franklin C; Bogyo M; McKerrow J H
Identification of a cDNA encoding an active asparaginyl endopeptidase of Schistosoma mansoni and its expression in Pichia pastoris.
FEBS letters 2000;466(2-3):244-8.
1999: Britton C; Redmond D L; Knox D P; McKerrow J H; Barry J D
Identification of promoter elements of parasite nematode genes in transgenic Caenorhabditis elegans.
Molecular and biochemical parasitology 1999;103(2):171-81.
1999: Selzer P M; Pingel S; Hsieh I; Ugele B; Chan V J; Engel J C; Bogyo M; Russell D G; Sakanari J A; McKerrow J H
Cysteine protease inhibitors as chemotherapy: lessons from a parasite target.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(20):11015-22.
1999: McKerrow J H
Development of cysteine protease inhibitors as chemotherapy for parasitic diseases: insights on safety, target validation, and mechanism of action.
International journal for parasitology 1999;29(6):833-7.
1999: Huete-Pérez J A; Engel J C; Brinen L S; Mottram J C; McKerrow J H
Protease trafficking in two primitive eukaryotes is mediated by a prodomain protein motif.
The Journal of biological chemistry 1999;274(23):16249-56.
1999: Chan V J; Selzer P M; McKerrow J H; Sakanari J A
Expression and alteration of the S2 subsite of the Leishmania major cathepsin B-like cysteine protease.
The Biochemical journal 1999;340 ( Pt 1)():113-7.
1999: McKerrow J H; Engel J C; Caffrey C R
Cysteine protease inhibitors as chemotherapy for parasitic infections.
Bioorganic & medicinal chemistry 1999;7(4):639-44.
1999: Troeberg L; Morty R E; Pike R N; Lonsdale-Eccles J D; Palmer J T; McKerrow J H; Coetzer T H
Cysteine proteinase inhibitors kill cultured bloodstream forms of Trypanosoma brucei brucei.
Experimental parasitology 1999;91(4):349-55.
1999: Lim K C; Sun E; Bahgat M; Bucks D; Guy R; Hinz R S; Cullander C; McKerrow J H
Blockage of skin invasion by schistosome cercariae by serine protease inhibitors.
The American journal of tropical medicine and hygiene 1999;60(3):487-92.
1999: McKerrow J H; Huima T; Lustigman S
Do filarid nematodes have a vascular system?
Parasitology today (Personal ed.) 1999;15(3):123.
1999: Engel J C; Doyle P S; McKerrow J H
[Trypanocidal effect of cysteine protease inhibitors in vitro and in vivo in experimental Chagas disease]
Medicina 1999;59 Suppl 2():171-5.
1998: Scheidt K A; Roush W R; McKerrow J H; Selzer P M; Hansell E; Rosenthal P J
Structure-based design, synthesis and evaluation of conformationally constrained cysteine protease inhibitors.
Bioorganic & medicinal chemistry 1998;6(12):2477-94.
1998: Roush W R; González F V; McKerrow J H; Hansell E
Design and synthesis of dipeptidyl alpha',beta'-epoxy ketones, potent irreversible inhibitors of the cysteine protease cruzain.
Bioorganic & medicinal chemistry letters 1998;8(19):2809-12.
1998: Engel J C; Doyle P S; Hsieh I; McKerrow J H
Cysteine protease inhibitors cure an experimental Trypanosoma cruzi infection.
The Journal of experimental medicine 1998;188(4):725-34.
1998: Stoka V; McKerrow J H; Cazzulo J J; Turk V
Substrate inhibition of cruzipain is not affected by the C-terminal domain.
FEBS letters 1998;429(2):129-33.
1998: Engel J C; Doyle P S; Palmer J; Hsieh I; Bainton D F; McKerrow J H
Cysteine protease inhibitors alter Golgi complex ultrastructure and function in Trypanosoma cruzi.
Journal of cell science 1998;111 ( Pt 5)():597-606.
1998: Britton C; McKerrow J H; Johnstone I L
Regulation of the Caenorhabditis elegans gut cysteine protease gene cpr-1: requirement for GATA motifs.
Journal of molecular biology 1998;283(1):15-27.
1997: Selzer P M; Chen X; Chan V J; Cheng M; Kenyon G L; Kuntz I D; Sakanari J A; Cohen F E; McKerrow J H
Leishmania major: molecular modeling of cysteine proteases and prediction of new nonpeptide inhibitors.
Experimental parasitology 1997;87(3):212-21.
1997: Hagen H E; Kläger S L; McKerrow J H; Ham P J
A simple assay for the detection of native and recombinant protease activity.
Analytical biochemistry 1997;251(1):121-2.
1997: Hagen H E; Kläger S L; McKerrow J H; Ham P J
Simulium damnosum s.l.: isolation and identification of prophenoloxidase following an infection with Onchocerca spp. using targeted differential display.
Experimental parasitology 1997;86(3):213-8.
1997: Ramzy R M; Faris R; Bahgat M; Helmy H; Franklin C; McKerrow J H
Evaluation of a stage-specific proteolytic enzyme of Schistosoma mansoni as a marker of exposure.
The American journal of tropical medicine and hygiene 1997;56(6):668-73.
1997: Ward W; Alvarado L; Rawlings N D; Engel J C; Franklin C; McKerrow J H
A primitive enzyme for a primitive cell: the protease required for excystation of Giardia.
Cell 1997;89(3):437-44.
1997: Ramakrishnan L; Valdivia R H; McKerrow J H; Falkow S
Mycobacterium marinum causes both long-term subclinical infection and acute disease in the leopard frog (Rana pipiens).
Infection and immunity 1997;65(2):767-73.
1997: Leptak C L; McKerrow J H
Schistosome egg granulomas and hepatic expression of TNF-alpha are dependent on immune priming during parasite maturation.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(1):301-7.
1997: McKerrow J H
Cytokine induction and exploitation in schistosome infections.
Parasitology 1997;115 Suppl():S107-12.
1996: Lustigman S; McKerrow J H; Shah K; Lui J; Huima T; Hough M; Brotman B
Cloning of a cysteine protease required for the molting of Onchocerca volvulus third stage larvae.
The Journal of biological chemistry 1996;271(47):30181-9.
1996: Ritter D M; McKerrow J H
Intercellular adhesion molecule 1 is the major adhesion molecule expressed during schistosome granuloma formation.
Infection and immunity 1996;64(11):4706-13.
1996: Wasilewski M M; Lim K C; Phillips J; McKerrow J H
Cysteine protease inhibitors block schistosome hemoglobin degradation in vitro and decrease worm burden and egg production in vivo.
Molecular and biochemical parasitology 1996;81(2):179-89.
1996: McKerrow J H
Parasitic infections--molecular diagnosis and rational drug design.
Biologicals : journal of the International Association of Biological Standardization 1996;24(3):207-8.
1996: Li R; Chen X; Gong B; Selzer P M; Li Z; Davidson E; Kurzban G; Miller R E; Nuzum E O; McKerrow J H; Fletterick R J; Gillmor S A; Craik C S; Kuntz I D; Cohen F E; Kenyon G L
Structure-based design of parasitic protease inhibitors.
Bioorganic & medicinal chemistry 1996;4(9):1421-7.
1996: Ghendler Y; Parizade M; Arnon R; McKerrow J H; Fishelson Z
Schistosoma mansoni: evidence for a 28-kDa membrane-anchored protease on schistosomula.
Experimental parasitology 1996;83(1):73-82.
1995: Hagen H E; Kläger S L; Chan V; Sakanari J A; McKerrow J H; Ham P J
Simulium damnosum s.l.: identification of inducible serine proteases following an Onchocerca infection by differential display reverse transcription PCR.
Experimental parasitology 1995;81(3):249-54.
1995: McKerrow J H; McGrath M E; Engel J C
The cysteine protease of Trypanosoma cruzi as a model for antiparasite drug design.
Parasitology today (Personal ed.) 1995;11(8):279-82.
1995: McGrath M E; Eakin A E; Engel J C; McKerrow J H; Craik C S; Fletterick R J
The crystal structure of cruzain: a therapeutic target for Chagas' disease.
Journal of molecular biology 1995;247(2):251-9.
1995: Brindley P J; Gam A A; McKerrow J H; Neva F A
Ss40: the zinc endopeptidase secreted by infective larvae of Strongyloides stercoralis.
Experimental parasitology 1995;80(1):1-7.
1994: Amiri P; Haak-Frendscho M; Robbins K; McKerrow J H; Stewart T; Jardieu P
Anti-immunoglobulin E treatment decreases worm burden and egg production in Schistosoma mansoni-infected normal and interferon gamma knockout mice.
The Journal of experimental medicine 1994;180(1):43-51.
1994: Mitro K; Bhagavathiammai A; Zhou O M; Bobbett G; McKerrow J H; Chokshi R; Chokshi B; James E R
Partial characterization of the proteolytic secretions of Acanthamoeba polyphaga.
Experimental parasitology 1994;78(4):377-85.
1994: Aldape K; Huizinga H; Bouvier J; McKerrow J
Naegleria fowleri: characterization of a secreted histolytic cysteine protease.
Experimental parasitology 1994;78(2):230-41.
1994: McKerrow J H; Sun E
Hepatic schistosomiasis.
Progress in liver diseases 1994;12():121-35.
1993: Ring C S; Sun E; McKerrow J H; Lee G K; Rosenthal P J; Kuntz I D; Cohen F E
Structure-based inhibitor design by using protein models for the development of antiparasitic agents.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(8):3583-7.
1993: McKerrow J H; Ritter D M
Using scid mice to study parasitic diseases.
Laboratory animal science 1993;43(2):136-8.
1993: Harth G; Andrews N; Mills A A; Engel J C; Smith R; McKerrow J H
Peptide-fluoromethyl ketones arrest intracellular replication and intercellular transmission of Trypanosoma cruzi.
Molecular and biochemical parasitology 1993;58(1):17-24.
1993: Eakin A E; McGrath M E; McKerrow J H; Fletterick R J; Craik C S
Production of crystallizable cruzain, the major cysteine protease from Trypanosoma cruzi.
The Journal of biological chemistry 1993;268(9):6115-8.
1993: Hong X; Bouvier J; Wong M M; Yamagata G Y; McKerrow J H
Brugia pahangi: identification and characterization of an aminopeptidase associated with larval molting.
Experimental parasitology 1993;76(2):127-33.
1993: McKerrow J H; Sun E; Rosenthal P J; Bouvier J
The proteases and pathogenicity of parasitic protozoa.
Annual review of microbiology 1993;47():821-53.
1992: McKerrow J H; Ritter D
Schistosomes and host TNF.
Parasitology today (Personal ed.) 1992;8(12):411-2.
1992: Clawson G A; Norbeck L L; Hatem C L; Rhodes C; Amiri P; McKerrow J H; Patierno S R; Fiskum G
Ca(2+)-regulated serine protease associated with the nuclear scaffold.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1992;3(11):827-38.
1992: Fishelson Z; Amiri P; Friend D S; Marikovsky M; Petitt M; Newport G; McKerrow J H
Schistosoma mansoni: cell-specific expression and secretion of a serine protease during development of cercariae.
Experimental parasitology 1992;75(1):87-98.
1992: Lustigman S; Brotman B; Huima T; Prince A M; McKerrow J H
Molecular cloning and characterization of onchocystatin, a cysteine proteinase inhibitor of Onchocerca volvulus.
The Journal of biological chemistry 1992;267(24):17339-46.
1992: McKerrow J H
The hemoglobinase of Schistosoma mansoni.
Rhode Island medicine 1992;75(4):208-11.
1992: Ray C; McKerrow J H
Gut-specific and developmental expression of a Caenorhabditis elegans cysteine protease gene.
Molecular and biochemical parasitology 1992;51(2):239-49.
1992: Amiri P; Locksley R M; Parslow T G; Sadick M; Rector E; Ritter D; McKerrow J H
Tumour necrosis factor alpha restores granulomas and induces parasite egg-laying in schistosome-infected SCID mice.
Nature 1992;356(6370):604-7.
1992: Eakin A E; Mills A A; Harth G; McKerrow J H; Craik C S
The sequence, organization, and expression of the major cysteine protease (cruzain) from Trypanosoma cruzi.
The Journal of biological chemistry 1992;267(11):7411-20.
1992: McKerrow J H
Pathogenesis in amebiasis: is it genetic or acquired?
Infectious agents and disease 1992;1(1):11-4.
1992: Yuan L; Craig S P; McKerrow J H; Wang C C
Steady-state kinetics of the schistosomal hypoxanthine-guanine phosphoribosyltransferase.
Biochemistry 1992;31(3):806-10.
1992: Reed S; Bouvier J; Hirata K; Que X; Pollack A S; Engel J C; Gillin F; McKerrow J H
A unique cysteine proteinase gene of pathogenic Entamoeba histolytica correlates with virulence.
Archives of medical research 1992;23(2):181-2.
1991: Cohen F E; Gregoret L M; Amiri P; Aldape K; Railey J; McKerrow J H
Arresting tissue invasion of a parasite by protease inhibitors chosen with the aid of computer modeling.
Biochemistry 1991;30(47):11221-9.
1991: McKerrow J H
New insights into the structure of a Trypanosoma cruzi protease.
Parasitology today (Personal ed.) 1991;7(6):132-3.
1991: McKerrow J H; Newport G; Fishelson Z
Recent insights into the structure and function of a larval proteinase involved in host infection by a multicellular parasite.
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.) 1991;197(2):119-24.
1991: Craig S P; Yuan L; Kuntz D A; McKerrow J H; Wang C C
High level expression in Escherichia coli of soluble, enzymatically active schistosomal hypoxanthine/guanine phosphoribosyltransferase and trypanosomal ornithine decarboxylase.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(6):2500-4.
1991: Brown M; Reed S; Levy J A; Busch M; McKerrow J H
Detection of HIV-1 in Entamoeba histolytica without evidence of transmission to human cells.
AIDS (London, England) 1991;5(1):93-6.
1990: Sakanari J A; McKerrow J H
Identification of the secreted neutral proteases from Anisakis simplex.
The Journal of parasitology 1990;76(5):625-30.
1990: Keene W E; Hidalgo M E; Orozco E; McKerrow J H
Entamoeba histolytica: correlation of the cytopathic effect of virulent trophozoites with secretion of a cysteine proteinase.
Experimental parasitology 1990;71(2):199-206.
1990: Yuan L; Craig S P; McKerrow J H; Wang C C
The hypoxanthine-guanine phosphoribosyltransferase of Schistosoma mansoni. Further characterization and gene expression in Escherichia coli.
The Journal of biological chemistry 1990;265(23):13528-32.
1990: Apodaca G; Rutka J T; Bouhana K; Berens M E; Giblin J R; Rosenblum M L; McKerrow J H; Banda M J
Expression of metalloproteinases and metalloproteinase inhibitors by fetal astrocytes and glioma cells.
Cancer research 1990;50(8):2322-9.
1990: Eakin A E; Bouvier J; Sakanari J A; Craik C S; McKerrow J H
Amplification and sequencing of genomic DNA fragments encoding cysteine proteases from protozoan parasites.
Molecular and biochemical parasitology 1990;39(1):1-8.
1990: Resnick S; Zimmer B; Pappagianis D; Eakin A; McKerrow J
Purification and amino-terminal sequence analysis of the complement-fixing and precipitin antigens from Coccidioides immitis.
Journal of clinical microbiology 1990;28(2):385-8.
1990: McKerrow J H; Brindley P; Brown M; Gam A A; Staunton C; Neva F A
Strongyloides stercoralis: identification of a protease that facilitates penetration of skin by the infective larvae.
Experimental parasitology 1990;70(2):134-43.
1990: Hidalgo M E; Hernández R; Keene W E; McKerrow J H; Orozco E
[Direct relation between secretion of proteolytic enzymes and virulence in Entamoeba histolytica]
Archivos de investigación médica 1990;21 Suppl 1():133-8.
1990: Apodaca G; McKerrow J H
Expression of proteolytic activity by cultures of Trichophyton rubrum.
Journal of medical and veterinary mycology : bi-monthly publication of the International Society for Human and Animal Mycology 1990;28(2):159-71.
1989: Reed S L; Keene W E; McKerrow J H
Thiol proteinase expression and pathogenicity of Entamoeba histolytica.
Journal of clinical microbiology 1989;27(12):2772-7.
1989: McKerrow J H
Molecular and biochemical studies of the cercarial proteinase of Schistosoma mansoni.
Memórias do Instituto Oswaldo Cruz 1989;84 Suppl 1():209-10.
1989: Apodaca G; McKerrow J H
Purification and characterization of a 27,000-Mr extracellular proteinase from Trichophyton rubrum.
Infection and immunity 1989;57(10):3072-80.
1989: Apodaca G; McKerrow J H
Regulation of Trichophyton rubrum proteolytic activity.
Infection and immunity 1989;57(10):3081-90.
1989: Sakanari J A; McKerrow J H
Anisakiasis.
Clinical microbiology reviews 1989;2(3):278-84.
1989: Sakanari J A; Staunton C E; Eakin A E; Craik C S; McKerrow J H
Serine proteases from nematode and protozoan parasites: isolation of sequence homologs using generic molecular probes.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(13):4863-7.
1989: Robertson B D; Bianco A T; McKerrow J H; Maizels R M
Toxocara canis: proteolytic enzymes secreted by the infective larvae in vitro.
Experimental parasitology 1989;69(1):30-6.
1989: Reed S L; Keene W E; McKerrow J H; Gigli I
Cleavage of C3 by a neutral cysteine proteinase of Entamoeba histolytica.
Journal of immunology (Baltimore, Md. : 1950) 1989;143(1):189-95.
1989: Rosenthal P J; McKerrow J H; Rasnick D; Leech J H
Plasmodium falciparum: inhibitors of lysosomal cysteine proteinases inhibit a trophozoite proteinase and block parasite development.
Molecular and biochemical parasitology 1989;35(2):177-83.
1989: Craig S P; Muralidhar M G; McKerrow J H; Wang C C
Evidence for a class of very small introns in the gene for hypoxanthine-guanine phosphoribosyltransferase in Schistosoma mansoni.
Nucleic acids research 1989;17(4):1635-47.
1989: Lackey A; James E R; Sakanari J A; Resnick S D; Brown M; Bianco A E; McKerrow J H
Extracellular proteases of Onchocerca.
Experimental parasitology 1989;68(2):176-85.
1989: McKerrow J H
Parasite proteases.
Experimental parasitology 1989;68(1):111-5.
1988: McKerrow J H; Sakanari J; Deardorff T L
Anisakiasis: revenge of the sushi parasite.
The New England journal of medicine 1988;319(18):1228-9.
1988: Rosenthal P J; McKerrow J H; Aikawa M; Nagasawa H; Leech J H
A malarial cysteine proteinase is necessary for hemoglobin degradation by Plasmodium falciparum.
The Journal of clinical investigation 1988;82(5):1560-6.
1988: Newport G R; McKerrow J H; Hedstrom R; Petitt M; McGarrigle L; Barr P J; Agabian N
Cloning of the proteinase that facilitates infection by schistosome parasites.
The Journal of biological chemistry 1988;263(26):13179-84.
1988: Sakanari J A; Loinaz H M; Deardorff T L; Raybourne R B; McKerrow J H; Frierson J G
Intestinal anisakiasis. A case diagnosed by morphologic and immunologic methods.
American journal of clinical pathology 1988;90(1):107-13.
1988: Craig S P; McKerrow J H; Newport G R; Wang C C
Analysis of cDNA encoding the hypoxanthine-guanine phosphoribosyltransferase (HGPRTase) of Schistosoma mansoni; a putative target for chemotherapy.
Nucleic acids research 1988;16(14B):7087-101.
1988: Amiri P; Sakanari J; Basch P; Newport G; McKerrow J H
The Schistosomatium douthitti cercarial elastase is biochemically and structurally distinct from that of Schistosoma mansoni.
Molecular and biochemical parasitology 1988;28(2):113-20.
1987: Newport G R; Harrison R A; McKerrow J; Tarr P; Kallestad J; Agabian N
Molecular cloning of Schistosoma mansoni myosin.
Molecular and biochemical parasitology 1987;26(1-2):29-38.
1987: Resnick S; Pappagianis D; McKerrow J H
Proteinase production by the parasitic cycle of the pathogenic fungus Coccidioides immitis.
Infection and immunity 1987;55(11):2807-15.
1987: Rosenthal P J; Kim K; McKerrow J H; Leech J H
Identification of three stage-specific proteinases of Plasmodium falciparum.
The Journal of experimental medicine 1987;166(3):816-21.
1987: McKerrow J H
Human fibroblast collagenase contains an amino acid sequence homologous to the zinc-binding site of Serratia protease.
The Journal of biological chemistry 1987;262(13):5943.
1987: Walker R; Parsche F; Bierbrier M; McKerrow J H
Tissue identification and histologic study of six lung specimens from Egyptian mummies.
American journal of physical anthropology 1987;72(1):43-8.
1987: Newport G; McKerrow J; Hedstrom R; Culpepper J; McGarrigle L; Agabian N
Schistosome elastases: biological importance, structure, function and stage-specific expression.
Biochemical Society symposium 1987;53():115-21.
1987: Banda M J; Werb Z; McKerrow J H
Elastin degradation.
Methods in enzymology 1987;144():288-305.
1986: Pino-Heiss S; Petitt M; Beckstead J H; McKerrow J H
Preparation of mouse monoclonal antibodies and evidence for a host immune response to the preacetabular gland proteinase of Schistosoma mansoni cercariae.
The American journal of tropical medicine and hygiene 1986;35(3):536-43.
1986: Keene W E; Petitt M G; Allen S; McKerrow J H
The major neutral proteinase of Entamoeba histolytica.
The Journal of experimental medicine 1986;163(3):536-49.
1986: Dovey H F; McKerrow J H; Aldritt S M; Wang C C
Purification and characterization of hypoxanthine-guanine phosphoribosyltransferase from Schistosoma mansoni. A potential target for chemotherapy.
The Journal of biological chemistry 1986;261(2):944-8.
1985: Asahi M; Lindquist R; Fukuyama K; Apodaca G; Epstein W L; McKerrow J H
Purification and characterization of major extracellular proteinases from Trichophyton rubrum.
The Biochemical journal 1985;232(1):139-44.
1985: McKerrow J H; Jones P; Sage H; Pino-Heiss S
Proteinases from invasive larvae of the trematode parasite Schistosoma mansoni degrade connective-tissue and basement-membrane macromolecules.
The Biochemical journal 1985;231(1):47-51.
1985: Dovey H F; McKerrow J H; Wang C C
Action of tubercidin and other adenosine analogs on Schistosoma mansoni schistosomules.
Molecular and biochemical parasitology 1985;16(2):185-98.
1985: Hotez P J; Trang N L; McKerrow J H; Cerami A
Isolation and characterization of a proteolytic enzyme from the adult hookworm Ancylostoma caninum.
The Journal of biological chemistry 1985;260(12):7343-8.
1985: Pino-Heiss S; Brown M; McKerrow J H
Schistosoma mansoni: degradation of host extracellular matrix by eggs and miracidia.
Experimental parasitology 1985;59(2):217-21.
1985: McKerrow J H; Pino-Heiss S; Lindquist R; Werb Z
Purification and characterization of an elastinolytic proteinase secreted by cercariae of Schistosoma mansoni.
The Journal of biological chemistry 1985;260(6):3703-7.
1985: McKerrow J H; Jeong K H; Beckstead J H
Enzyme histochemical comparison of biomphalaria glabrata amebocytes with human granuloma macrophages.
Journal of leukocyte biology 1985;37(3):341-7.
1984: Taylor R N; Welch K L; Sklar D M; McKerrow J H; Creasy R K
Heterotopic skin in the uterus. A report of an unusual case.
The Journal of reproductive medicine 1984;29(11):837-40.
1984: Dovey H F; McKerrow J H; Wang C C
Purine salvage in Schistosoma mansoni schistosomules.
Molecular and biochemical parasitology 1984;11():157-67.
1983: Tzeng S; McKerrow J H; Fukuyama K; Jeong K; Epstein W L
Degradation of purified skin keratin by a proteinase secreted from Schistosoma mansoni cercariae.
The Journal of parasitology 1983;69(5):992-4.
1983: Stark D D; Bass N M; Moss A A; Bacon B R; McKerrow J H; Cann C E; Brito A; Goldberg H I
Nuclear magnetic resonance imaging of experimentally induced liver disease.
Radiology 1983;148(3):743-51.
1983: Keene W E; Jeong K H; McKerrow J H; Werb Z
Degradation of extracellular matrix by larvae of Schistosoma mansoni. II. Degradation by newly transformed and developing schistosomula.
Laboratory investigation; a journal of technical methods and pathology 1983;49(2):201-7.
1983: McKerrow J H; Keene W E; Jeong K H; Werb Z
Degradation of extracellular matrix by larvae of Schistosoma mansoni. I. Degradation by cercariae as a model for initial parasite invasion of host.
Laboratory investigation; a journal of technical methods and pathology 1983;49(2):195-200.
1982: Tzeng S; McKerrow J H; Jeong K; Fukuyama K; Epstein W L
Partial purification and characterization of an inhibitor from newborn-rat epidermis with activity against the proteinase of Schistosoma mansoni cercariae.
The Biochemical journal 1982;207(3):479-84.
1982: Demanes D J; Friedman M A; McKerrow J H; Hoffman P G
Hormone receptors in hepatoblastoma: a demonstration of both estrogen and progesterone receptors.
Cancer 1982;50(9):1828-32.
1982: Werb Z; Banda M J; McKerrow J H; Sandhaus R A
Elastases and elastin degradation.
The Journal of investigative dermatology 1982;79 Suppl 1():154s-159s.
1982: McKerrow J H; Jeong K H
Schistosoma mansoni: cercarial degradation of a radioactively labeled collagen gel.
Experimental parasitology 1982;53(2):249-54.
1982: Townsend J J; Stroop W G; Baringer J R; Wolinsky J S; McKerrow J H; Berg B O
Neuropathology of progressive rubella panencephalitis after childhood rubella.
Neurology 1982;32(2):185-90.

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