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Sandra McLachlan

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Sepehr Hamidi; Sandra M McLachlan; Ramachandran Murali; Chun-Rong Chen; Basil Rapoport
Probing structural variability at the N terminus of the TSH receptor with a murine monoclonal antibody that distinguishes between two receptor conformational forms.
Chun-Rong Chen; Sandra M McLachlan; Larry M Salazar; Basil Rapoport
The thyrotropin receptor hinge region as a surrogate ligand: identification of loci contributing to the coupling of thyrotropin binding and receptor activation.
Sandra M McLachlan; Holly Aliesky; Chun-Rong Chen; Gao Chong; Basil Rapoport
Breaking tolerance in transgenic mice expressing the human TSH receptor A-subunit: thyroiditis, epitope spreading and adjuvant as a 'double edged sword'.

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2013: Sepehr Hamidi; Sandra M McLachlan; Ramachandran Murali; Chun-Rong Chen; Basil Rapoport
Probing structural variability at the N terminus of the TSH receptor with a murine monoclonal antibody that distinguishes between two receptor conformational forms.
Endocrinology 2013;154(1):562-71.
2012: Chun-Rong Chen; Sandra M McLachlan; Larry M Salazar; Basil Rapoport
The thyrotropin receptor hinge region as a surrogate ligand: identification of loci contributing to the coupling of thyrotropin binding and receptor activation.
Endocrinology 2012;153(10):5058-67.
2012: Sandra M McLachlan; Holly Aliesky; Chun-Rong Chen; Gao Chong; Basil Rapoport
Breaking tolerance in transgenic mice expressing the human TSH receptor A-subunit: thyroiditis, epitope spreading and adjuvant as a 'double edged sword'.
PloS one 2012;7(9):e43517.
2012: Chun-Rong Chen; Sandra M McLachlan; Larry M Salazar; Basil Rapoport
Novel information on the epitope of an inverse agonist monoclonal antibody provides insight into the structure of the TSH receptor.
PloS one 2012;7(2):e31973.
2011: Sandra M McLachlan; Kristine Alpi; Basil Rapoport
Review and hypothesis: does Graves' disease develop in non-human great apes?
Thyroid : official journal of the American Thyroid Association 2011;21(12):1359-66.
2011: Chun-Rong Chen; Holly Aliesky; Basil Rapoport; Sandra M McLachlan
An attempt to induce "Graves' disease of the gonads" by immunizing mice with the luteinizing hormone receptor provides insight into breaking tolerance to self-antigens.
Thyroid : official journal of the American Thyroid Association 2011;21(7):773-81.
2011: Sandra M McLachlan; Lu Lu; Holly Aliesky; Robert Williams; Basil Rapoport
Distinct genetic signatures for variability in total and free serum thyroxine levels in four sets of recombinant inbred mice.
Endocrinology 2011;152(3):1172-9.
2011: Chun-Rong Chen; Sandra M McLachlan; Basil Rapoport
Evidence that the thyroid-stimulating hormone (TSH) receptor transmembrane domain influences kinetics of TSH binding to the receptor ectodomain.
The Journal of biological chemistry 2011;286(8):6219-24.
2011: Sandra M McLachlan; Holly Aliesky; Chun-Rong Chen; Robert W Williams; Basil Rapoport
Exceptional hyperthyroidism and a role for both major histocompatibility class I and class II genes in a murine model of Graves' disease.
PloS one 2011;6(6):e21378.
2011: Sepehr Hamidi; Chun-Rong Chen; Yumiko Mizutori-Sasai; Sandra M McLachlan; Basil Rapoport
Relationship between thyrotropin receptor hinge region proteolytic posttranslational modification and receptor physiological function.
Molecular endocrinology (Baltimore, Md.) 2011;25(1):184-94.
2010: Sepehr Hamidi; Holly Aliesky; Chun-Rong Chen; Basil Rapoport; Sandra M McLachlan
Variable suppression of serum thyroxine in female mice of different inbred strains by triiodothyronine administered in drinking water.
Thyroid : official journal of the American Thyroid Association 2010;20(10):1157-62.
2010: Chun-Rong Chen; Sepehr Hamidi; Helen Braley-Mullen; Yuji Nagayama; Catherine J Bresee; Holly Aliesky; Basil Rapoport; Sandra M McLachlan
Antibodies to thyroid peroxidase arise spontaneously with age in NOD.H-2h4 mice and appear after thyroglobulin antibodies.
Endocrinology 2010;151(9):4583-93.
2010: Venu Lagishetty; Alexander Misharin; Nancy Q Liu; Thomas S Lisse; Rene Chun; Yi Ouyang; Sandra M McLachlan; John S Adams; Martin Hewison
Vitamin D deficiency in mice impairs colonic antibacterial activity and predisposes to colitis.
Endocrinology 2010;151(6):2423-32.
2010: Chun-Rong Chen; Sandra M McLachlan; Basil Rapoport
Thyrotropin (TSH) receptor residue E251 in the extracellular leucine-rich repeat domain is critical for linking TSH binding to receptor activation.
Endocrinology 2010;151(4):1940-7.
2009: Alexander Misharin; Yuji Nagayama; Holly Aliesky; Yumiko Mizutori; Basil Rapoport; Sandra M McLachlan
Attenuation of induced hyperthyroidism in mice by pretreatment with thyrotropin receptor protein: deviation of thyroid-stimulating to nonfunctional antibodies.
Endocrinology 2009;150(8):3944-52.
2009: Chun-Rong Chen; Sandra M McLachlan; Basil Rapoport
A monoclonal antibody with thyrotropin (TSH) receptor inverse agonist and TSH antagonist activities binds to the receptor hinge region as well as to the leucine-rich domain.
Endocrinology 2009;150(7):3401-8.
2009: Alexander Misharin; Yuji Nagayama; Holly Aliesky; Basil Rapoport; Sandra M McLachlan
Studies in mice deficient for the autoimmune regulator (Aire) and transgenic for the thyrotropin receptor reveal a role for Aire in tolerance for thyroid autoantigens.
Endocrinology 2009;150(6):2948-56.
2009: Alexander Misharin; Basil Rapoport; Sandra M McLachlan
Thyroid antigens, not central tolerance, control responses to immunization in BALB/c versus C57BL/6 mice.
Thyroid : official journal of the American Thyroid Association 2009;19(5):503-9.
2009: Yumiko Mizutori; Chun-Rong Chen; Francesco Latrofa; Sandra M McLachlan; Basil Rapoport
Evidence that shed thyrotropin receptor A subunits drive affinity maturation of autoantibodies causing Graves' disease.
The Journal of clinical endocrinology and metabolism 2009;94(3):927-35.
2009: Alexander Misharin; Martin Hewison; Chun-Rong Chen; Venu Lagishetty; Holly Aliesky; Yumiko Mizutori; Basil Rapoport; Sandra M McLachlan
Vitamin D deficiency modulates Graves' hyperthyroidism induced in BALB/c mice by thyrotropin receptor immunization.
Endocrinology 2009;150(2):1051-60.
2008: Yumiko Mizutori; Yuji Nagayama; D Flower; Alexander Misharin; Holly Aliesky; Basil Rapoport; Sandra M McLachlan
Role of the transgenic human thyrotropin receptor A-subunit in thyroiditis induced by A-subunit immunization and regulatory T cell depletion.
Clinical and experimental immunology 2008;154(3):305-15.
2008: Sandra M McLachlan; Basil Rapoport
Thyroid peroxidase autoantibody epitopes revisited*.
Clinical endocrinology 2008;69(4):526-7.
2008: Basil Rapoport; Sandra M McLachlan
Whither TSH receptor blocking antibodies in the treatment of Graves' disease?
Thyroid : official journal of the American Thyroid Association 2008;18(7):695-6.
2008: Chun-Rong Chen; Sandra M McLachlan; Basil Rapoport
Identification of key amino acid residues in a thyrotropin receptor monoclonal antibody epitope provides insight into its inverse agonist and antagonist properties.
Endocrinology 2008;149(7):3427-34.
2008: Yumiko Mizutori; Chun-Rong Chen; Sandra M McLachlan; Basil Rapoport
The thyrotropin receptor hinge region is not simply a scaffold for the leucine-rich domain but contributes to ligand binding and signal transduction.
Molecular endocrinology (Baltimore, Md.) 2008;22(5):1171-82.
2008: Sandra M McLachlan; Holly Aliesky; Pavel N Pichurin; Chun-Rong Chen; Robert Williams; Basil Rapoport
Shared and unique susceptibility genes in a mouse model of Graves' disease determined in BXH and CXB recombinant inbred mice.
Endocrinology 2008;149(4):2001-9.
2007: Sandra M McLachlan; Yuji Nagayama; Pavel N Pichurin; Yumiko Mizutori; Chun-Rong Chen; Alexander Misharin; Holly Aliesky; Basil Rapoport
The link between Graves' disease and Hashimoto's thyroiditis: a role for regulatory T cells.
Endocrinology 2007;148(12):5724-33.
2007: Basil Rapoport; Sandra M McLachlan
The thyrotropin receptor in Graves' disease.
Thyroid : official journal of the American Thyroid Association 2007;17(10):911-22.
2007: Sandra M McLachlan; Basil Rapoport
Thyroid peroxidase as an autoantigen.
Thyroid : official journal of the American Thyroid Association 2007;17(10):939-48.
2007: Chun-Rong Chen; Sandra M McLachlan; Basil Rapoport
Suppression of thyrotropin receptor constitutive activity by a monoclonal antibody with inverse agonist activity.
Endocrinology 2007;148(5):2375-82.
2006: Pavel N Pichurin; Nancy Pham; Chella S David; Basil Rapoport; Sandra M McLachlan
HLA-DR3 transgenic mice immunized with adenovirus encoding the thyrotropin receptor: T cell epitopes and functional analysis of the CD40 Graves' polymorphism.
Thyroid : official journal of the American Thyroid Association 2006;16(12):1221-7.
2006: Holly Aliesky; Pavel N Pichurin; Chun-Rong Chen; Robert Williams; Basil Rapoport; Sandra M McLachlan
Probing the genetic basis for thyrotropin receptor antibodies and hyperthyroidism in immunized CXB recombinant inbred mice.
Endocrinology 2006;147(6):2789-800.
2006: Chun-Rong Chen; Gregorio Chazenbalk; Kolja Wawrowsky; Sandra M McLachlan; Basil Rapoport
Evidence that human thyroid cells express uncleaved, single-chain thyrotropin receptors on their surface.
Endocrinology 2006;147(6):3107-13.
2006: Chun-Rong Chen; Holly Aliesky; Jin Guo; Basil Rapoport; Sandra M McLachlan
Blockade of costimulation between T cells and antigen-presenting cells: an approach to suppress murine Graves' disease induced using thyrotropin receptor-expressing adenovirus.
Thyroid : official journal of the American Thyroid Association 2006;16(5):427-34.
2006: Jin Guo; Sandra M McLachlan; Basil Rapoport
Antibodies focused on the human autoantibody immunodominant region are induced by B lymphocytes that constitutively express thyroid peroxidase diverted to the major histocompatibility complex II pathway.
Thyroid : official journal of the American Thyroid Association 2006;16(4):343-9.
2006: Pavel N Pichurin; Chun-Rong Chen; Gregorio Chazenbalk; Holly Aliesky; Nancy Pham; Basil Rapoport; Sandra M McLachlan
Targeted expression of the human thyrotropin receptor A-subunit to the mouse thyroid: insight into overcoming the lack of response to A-subunit adenovirus immunization.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(1):668-76.
2005: Mrinalini Kala; Chun-Rong Chen; Sandra M McLachlan; Basil Rapoport; Holly Aliesky; Harold A Chapman
Cathepsin S is not crucial to TSHR processing and presentation in a murine model of Graves' disease.
Immunology 2005;116(4):532-40.
2005: Chun-Rong Chen; Rula Abbud; Charles Wang; Yongxi Tan; Basil Rapoport; Sandra M McLachlan
Gene expression profiles differ markedly in mouse strains that are (or are not) susceptible to hyperthyroidism induced using thyrotropin receptor-expressing adenovirus.
Thyroid : official journal of the American Thyroid Association 2005;15(11):1229-37.
2005: Jin Guo; Sandra M McLachlan; Pavel N Pichurin; Chun-Rong Chen; Nancy Pham; Holly Aliesky; Chella S David; Basil Rapoport
Relationship between thyroid peroxidase T cell epitope restriction and antibody recognition of the autoantibody immunodominant region in human leukocyte antigen DR3 transgenic mice.
Endocrinology 2005;146(11):4961-7.
2005: Sandra M McLachlan; Yuji Nagayama; Basil Rapoport
Insight into Graves' hyperthyroidism from animal models.
Endocrine reviews 2005;26(6):800-32.
2005: Gregorio Chazenbalk; Pavel N Pichurin; Jin Guo; Basil Rapoport; Sandra M McLachlan
Interactions between the mannose receptor and thyroid autoantigens.
Clinical and experimental immunology 2005;139(2):216-24.
2005: Sandra M McLachlan; Helen Braley-Mullen; Chun-Rong Chen; Holly Aliesky; Pavel N Pichurin; Basil Rapoport
Dissociation between iodide-induced thyroiditis and antibody-mediated hyperthyroidism in NOD.H-2h4 mice.
Endocrinology 2005;146(1):294-300.
2004: Pavel N Pichurin; Gregorio Chazenbalk; Holly Aliesky; Oxana Pichurina; Basil Rapoport; Sandra M McLachlan
"Hijacking" the thyrotropin receptor: A chimeric receptor-lysosome associated membrane protein enhances deoxyribonucleic acid vaccination and induces Graves' hyperthyroidism.
Endocrinology 2004;145(12):5504-14.
2004: Chun-Rong Chen; Holly Aliesky; Pavel N Pichurin; Yuji Nagayama; Sandra M McLachlan; Basil Rapoport
Susceptibility rather than resistance to hyperthyroidism is dominant in a thyrotropin receptor adenovirus-induced animal model of Graves' disease as revealed by BALB/c-C57BL/6 hybrid mice.
Endocrinology 2004;145(11):4927-33.
2004: Francesco Latrofa; Gregorio Chazenbalk; Sandra M McLachlan; Basil Rapoport
Evidence that the thyrotropin receptor protease is membrane-associated and is not within lipid rafts.
Thyroid : official journal of the American Thyroid Association 2004;14(10):801-5.
2004: Francesco Latrofa; Martin Phillips; Basil Rapoport; Sandra M McLachlan
Human monoclonal thyroglobulin autoantibodies: epitopes and immunoglobulin genes.
The Journal of clinical endocrinology and metabolism 2004;89(10):5116-23.
2004: Damien Bresson; Martine Pugnière; Françoise Roquet; Sandra A Rebuffat; Brigitte N-Guyen; Martine Cerutti; Jin Guo; Sandra M McLachlan; Basil Rapoport; Valérie Estienne; Jean Ruf; Thierry Chardès; Sylvie Péraldi-Roux
Directed mutagenesis in region 713-720 of human thyroperoxidase assigns 713KFPED717 residues as being involved in the B domain of the discontinuous immunodominant region recognized by human autoantibodies.
The Journal of biological chemistry 2004;279(37):39058-67.
2004: Francesco Latrofa; Gregorio Chazenbalk; Pavel N Pichurin; Chun-Rong Chen; Sandra M McLachlan; Basil Rapoport
Affinity-enrichment of thyrotropin receptor autoantibodies from Graves' patients and normal individuals provides insight into their properties and possible origin from natural antibodies.
The Journal of clinical endocrinology and metabolism 2004;89(9):4734-45.
2004: Jin Guo; Pavel N Pichurin; John C Morris; Basil Rapoport; Sandra M McLachlan
Naked deoxyribonucleic acid vaccination induces recognition of diverse thyroid peroxidase T cell epitopes.
Endocrinology 2004;145(8):3671-8.
2004: Sandra M McLachlan; Basil Rapoport
Why measure thyroglobulin autoantibodies rather than thyroid peroxidase autoantibodies?
Thyroid : official journal of the American Thyroid Association 2004;14(7):510-20.
2004: Sandra M McLachlan; Basil Rapoport
Thyroid stimulating monoclonal antibodies: overcoming the road blocks and the way forward.
Clinical endocrinology 2004;61(1):10-8.
2004: Gregorio Chazenbalk; Francesco Latrofa; Sandra M McLachlan; Basil Rapoport
Thyroid stimulation does not require antibodies with identical epitopes but does involve recognition of a critical conformation at the N terminus of the thyrotropin receptor A-subunit.
The Journal of clinical endocrinology and metabolism 2004;89(4):1788-93.
2004: Pavel N Pichurin; Chun-Rong Chen; Yuji Nagayama; Oxana Pichurina; Basil Rapoport; Sandra M McLachlan
Evidence that factors other than particular thyrotropin receptor T cell epitopes contribute to the development of hyperthyroidism in murine Graves' disease.
Clinical and experimental immunology 2004;135(3):391-7.
2004: Pavel N Pichurin; Oxana Pichurina; Russell C Marians; Chun-Rong Chen; terry Davies; Basil Rapoport; Sandra M McLachlan
Thyrotropin receptor knockout mice: studies on immunological tolerance to a major thyroid autoantigen.
Endocrinology 2004;145(3):1294-301.
2004: Chun-Rong Chen; Pavel N Pichurin; Gregorio Chazenbalk; Holly Aliesky; Yuji Nagayama; Sandra M McLachlan; Basil Rapoport
Low-dose immunization with adenovirus expressing the thyroid-stimulating hormone receptor A-subunit deviates the antibody response toward that of autoantibodies in human Graves' disease.
Endocrinology 2004;145(1):228-33.
2004: Gregorio Chazenbalk; Chun-Rong Chen; Sandra M McLachlan; Basil Rapoport
Does thyrotropin cleave its cognate receptor?
Endocrinology 2004;145(1):4-10.
2003: Pavel N Pichurin; Holly Aliesky; Chun-Rong Chen; Yuji Nagayama; Basil Rapoport; Sandra M McLachlan
Thyrotrophin receptor-specific memory T cell responses require normal B cells in a murine model of Graves' disease.
Clinical and experimental immunology 2003;134(3):396-402.
2003: Pavel N Pichurin; Chun-Rong Chen; Oxana Pichurina; Chella S David; Basil Rapoport; Sandra M McLachlan
Thyrotropin receptor-DNA vaccination of transgenic mice expressing HLA-DR3 or HLA-DQ6b.
Thyroid : official journal of the American Thyroid Association 2003;13(10):911-7.
2003: Chun-Rong Chen; Gregorio Chazenbalk; Sandra M McLachlan; Basil Rapoport
Evidence that the C terminus of the A subunit suppresses thyrotropin receptor constitutive activity.
Endocrinology 2003;144(9):3821-7.
2003: Chun-Rong Chen; Pavel N Pichurin; Yuji Nagayama; Francesco Latrofa; Basil Rapoport; Sandra M McLachlan
The thyrotropin receptor autoantigen in Graves disease is the culprit as well as the victim.
The Journal of clinical investigation 2003;111(12):1897-904.
2003: Jin Guo; Pavel N Pichurin; Yuji Nagayama; Basil Rapoport; Sandra M McLachlan
Insight into antibody responses induced by plasmid or adenoviral vectors encoding thyroid peroxidase, a major thyroid autoantigen.
Clinical and experimental immunology 2003;132(3):408-15.
2003: Lise Schwarz-Lauer; Pavel N Pichurin; Chun-Rong Chen; Yuji Nagayama; Charmaine Paras; John C Morris; Basil Rapoport; Sandra M McLachlan
The cysteine-rich amino terminus of the thyrotropin receptor is the immunodominant linear antibody epitope in mice immunized using naked deoxyribonucleic acid or adenovirus vectors.
Endocrinology 2003;144(5):1718-25.
2003: Chun-Rong Chen; Gregorio Chazenbalk; Sandra M McLachlan; Basil Rapoport
Targeted restoration of cleavage in a noncleaving thyrotropin receptor demonstrates that cleavage is insufficient to enhance ligand-independent activity.
Endocrinology 2003;144(4):1324-30.
2003: Francesco Latrofa; Pavel N Pichurin; Jin Guo; Basil Rapoport; Sandra M McLachlan
Thyroglobulin-thyroperoxidase autoantibodies are polyreactive, not bispecific: analysis using human monoclonal autoantibodies.
The Journal of clinical endocrinology and metabolism 2003;88(1):371-8.
2002: Pavel N Pichurin; Jin Guo; Valérie Estienne; Pierre Carayon; Jean Ruf; Basil Rapoport; Sandra M McLachlan
Evidence that the complement control protein-epidermal growth factor-like domain of thyroid peroxidase lies on the fringe of the immunodominant region recognized by autoantibodies.
Thyroid : official journal of the American Thyroid Association 2002;12(12):1085-95.
2002: Pavel N Pichurin; Lise Schwarz-Lauer; Helen Braley-Mullen; Charmaine Paras; Oxana Pichurina; John C Morris; Basil Rapoport; Sandra M McLachlan
Peptide scanning for thyrotropin receptor T-cell epitopes in mice vaccinated with naked DNA.
Thyroid : official journal of the American Thyroid Association 2002;12(9):755-64.
2002: Stéphanie Blanchin; Valérie Estienne; Jin Guo; Basil Rapoport; Sandra M McLachlan; Pierre Carayon; Jean Ruf
Human thyroperoxidase folds in one complex B-cell immunodominant region.
Biochemical and biophysical research communications 2002;295(5):1118-24.
2002: Gregorio Chazenbalk; Pavel N Pichurin; Chun-Rong Chen; Francesco Latrofa; Alan P Johnstone; Sandra M McLachlan; Basil Rapoport
Thyroid-stimulating autoantibodies in Graves disease preferentially recognize the free A subunit, not the thyrotropin holoreceptor.
The Journal of clinical investigation 2002;110(2):209-17.
2002: Pavel N Pichurin; Oxana Pichurina; Gregorio Chazenbalk; Charmaine Paras; Chun-Rong Chen; Basil Rapoport; Sandra M McLachlan
Immune deviation away from Th1 in interferon-gamma knockout mice does not enhance TSH receptor antibody production after naked DNA vaccination.
Endocrinology 2002;143(4):1182-9.
2002: Lise Schwarz-Lauer; Gregorio Chazenbalk; Sandra M McLachlan; Y Ochi; Yuji Nagayama; Basil Rapoport
Evidence for a simplified view of autoantibody interactions with the thyrotropin receptor.
Thyroid : official journal of the American Thyroid Association 2002;12(2):115-20.
2001: Basil Rapoport; Sandra M McLachlan
Thyroid autoimmunity.
The Journal of clinical investigation 2001;108(9):1253-9.
2001: Pavel N Pichurin; XM Yan; Loredana Farilla; Jin Guo; Gregorio Chazenbalk; Basil Rapoport; Sandra M McLachlan
Naked TSH receptor DNA vaccination: A TH1 T cell response in which interferon-gamma production, rather than antibody, dominates the immune response in mice.
Endocrinology 2001;142(8):3530-6.
2001: Chun-Rong Chen; K Tanaka; Gregorio Chazenbalk; Sandra M McLachlan; Basil Rapoport
A full biological response to autoantibodies in Graves' disease requires a disulfide-bonded loop in the thyrotropin receptor N terminus homologous to a laminin epidermal growth factor-like domain.
The Journal of biological chemistry 2001;276(18):14767-72.
2001: Pavel N Pichurin; Jin Guo; X Yan; Basil Rapoport; Sandra M McLachlan
Human monoclonal autoantibodies to B-cell epitopes outside the thyroid peroxidase autoantibody immunodominant region.
Thyroid : official journal of the American Thyroid Association 2001;11(4):301-13.
2001: Gregorio Chazenbalk; Sandra M McLachlan; Chun-Rong Chen; Basil Rapoport
Insight into thyrotropin receptor cleavage by engineering the single polypeptide chain luteinizing hormone receptor into a cleaving, two subunit receptor.
European journal of biochemistry / FEBS 2001;268(8):2261-9.
2001: Gregorio Chazenbalk; Sandra M McLachlan; Pavel N Pichurin; XM Yan; Basil Rapoport
A prion-like shift between two conformational forms of a recombinant thyrotropin receptor A-subunit module: purification and stabilization using chemical chaperones of the form reactive with Graves' autoantibodies.
The Journal of clinical endocrinology and metabolism 2001;86(3):1287-93.
2001: K Tanaka; Gregorio Chazenbalk; Basil Rapoport; Sandra M McLachlan
Reassessment of the location of the thyrotropin receptor 50 amino acid "insertion" provides evidence in favor of a second downstream cleavage site.
Thyroid : official journal of the American Thyroid Association 2001;11(2):111-4.
2001: Jin Guo; XM Yan; Sandra M McLachlan; Basil Rapoport
Search for the autoantibody immunodominant region on thyroid peroxidase: epitopic footprinting with a human monoclonal autoantibody locates a facet on the native antigen containing a highly conformational epitope.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(2):1327-33.
2000: XM Yan; Jin Guo; Pavel N Pichurin; K Tanaka; Juan Carlos Jaume; Basil Rapoport; Sandra M McLachlan
Cytokines, IgG subclasses and costimulation in a mouse model of thyroid autoimmunity induced by injection of fibroblasts co-expressing MHC class II and thyroid autoantigens.
Clinical and experimental immunology 2000;122(2):170-9.
2000: Loredana Farilla; Francesco Dotta; Umberto Di Mario; Basil Rapoport; Sandra M McLachlan
Presence of interleukin 4 or interleukin 10, but not both cytokines, in pancreatic tissue of two patients with recently diagnosed diabetes mellitus type I.
Autoimmunity 2000;32(3):161-6.
2000: K Tanaka; Gregorio Chazenbalk; Sandra M McLachlan; Basil Rapoport
Evidence that cleavage of the thyrotropin receptor involves a "molecular ruler" mechanism: deletion of amino acid residues 305-320 causes a spatial shift in cleavage site 1 independent of amino acid motif.
Endocrinology 2000;141(10):3573-7.
2000: Basil Rapoport; R Alsabeh; D Aftergood; Sandra M McLachlan
Elephantiasic pretibial myxedema: insight into and a hypothesis regarding the pathogenesis of the extrathyroidal manifestations of Graves' disease.
Thyroid : official journal of the American Thyroid Association 2000;10(8):685-92.
2000: Sandra M McLachlan; Basil Rapoport
Autoimmune response to the thyroid in humans: thyroid peroxidase--the common autoantigenic denominator.
International reviews of immunology 2000;19(6):587-618.
2000: Jin Guo; Y Wang; Basil Rapoport; Sandra M McLachlan
Evidence for antigen presentation to sensitized T cells by thyroid peroxidase (TPO)-specific B cells in mice injected with fibroblasts co-expressing TPO and MHC class II.
Clinical and experimental immunology 2000;119(1):38-46.
1999: K Tanaka; Gregorio Chazenbalk; Sandra M McLachlan; Basil Rapoport
Subunit structure of thyrotropin receptors expressed on the cell surface.
The Journal of biological chemistry 1999;274(48):33979-84.
1999: Gregorio Chazenbalk; Pavel N Pichurin; Sandra M McLachlan; Basil Rapoport
A direct binding assay for thyrotropin receptor autoantibodies.
Thyroid : official journal of the American Thyroid Association 1999;9(11):1057-61.
1999: Gregorio Chazenbalk; K Tanaka; Sandra M McLachlan; Basil Rapoport
On the functional importance of thyrotropin receptor intramolecular cleavage.
Endocrinology 1999;140(10):4516-20.
1999: Ayumu Kakinuma; Isao Morimoto; T Kuroda; Takashi Fujihira; Sumiya Eto; Sandra M McLachlan; Basil Rapoport
Comparison of recombinant human thyrotropin receptors versus porcine thyrotropin receptors in the thyrotropin binding inhibition assay for thyrotropin receptor autoantibodies.
Thyroid : official journal of the American Thyroid Association 1999;9(9):849-55.
1999: Jin Guo; Y Wang; Juan Carlos Jaume; Basil Rapoport; Sandra M McLachlan
Rarity of autoantibodies to a major autoantigen, thyroid peroxidase, that interact with denatured antigen or with epitopes outside the immunodominant region.
Clinical and experimental immunology 1999;117(1):19-29.
1999: Juan Carlos Jaume; J Guo; Y Wang; Basil Rapoport; Sandra M McLachlan
Cellular thyroid peroxidase (TPO), unlike purified TPO and adjuvant, induces antibodies in mice that resemble autoantibodies in human autoimmune thyroid disease.
The Journal of clinical endocrinology and metabolism 1999;84(5):1651-7.
1999: K Tanaka; Gregorio Chazenbalk; Sandra M McLachlan; Basil Rapoport
The shed thyrotropin receptor is primarily a carboxyl terminal truncated form of the A subunit, not the entire A subunit.
Molecular and cellular endocrinology 1999;150(1-2):113-9.
1999: Juan Carlos Jaume; Jin Guo; D L Pauls; M Zakarija; J M McKenzie; Janice A Egeland; CAROL BUREK; Noel R Rose; William H Hoffman; Basil Rapoport; Sandra M McLachlan
Evidence for genetic transmission of thyroid peroxidase autoantibody epitopic "fingerprints".
The Journal of clinical endocrinology and metabolism 1999;84(4):1424-31.
1999: Gregorio Chazenbalk; Y Wang; Jin Guo; J S Hutchison; D Segal; Juan Carlos Jaume; Sandra M McLachlan; Basil Rapoport
A mouse monoclonal antibody to a thyrotropin receptor ectodomain variant provides insight into the exquisite antigenic conformational requirement, epitopes and in vivo concentration of human autoantibodies.
The Journal of clinical endocrinology and metabolism 1999;84(2):702-10.
1999: K Tanaka; Gregorio Chazenbalk; Sandra M McLachlan; Basil Rapoport
Thyrotropin receptor cleavage at site 1 involves two discontinuous segments at each end of the unique 50-amino acid insertion.
The Journal of biological chemistry 1999;274(4):2093-6.
1999: Jin Guo; Basil Rapoport; Sandra M McLachlan
Balance of Th1/Th2 cytokines in thyroid autoantibody synthesis in vitro.
Autoimmunity 1999;30(1):1-9.
1999: Juan Carlos Jaume; Basil Rapoport; Sandra M McLachlan
Lack of female bias in a mouse model of autoimmune hyperthyroidism (Graves' disease).
Autoimmunity 1999;29(4):269-72.
1998: Basil Rapoport; Gregorio Chazenbalk; Juan Carlos Jaume; Sandra M McLachlan
The thyrotropin (TSH) receptor: interaction with TSH and autoantibodies.
Endocrine reviews 1998;19(6):673-716.
1998: J Guo; Sandra M McLachlan; S Hutchison; Basil Rapoport
The greater glycan content of recombinant human thyroid peroxidase of mammalian than of insect cell origin facilitates purification to homogeneity of enzymatically protein remaining soluble at high concentration.
Endocrinology 1998;139(3):999-1005.
1998: J Guo; RS McIntosh; B Czarnocka; Anthony P Weetman; Basil Rapoport; Sandra M McLachlan
Relationship between autoantibody epitopic recognition and immunoglobulin gene usage.
Clinical and experimental immunology 1998;111(2):408-14.
1998: K Tanaka; Gregorio Chazenbalk; Sandra M McLachlan; Basil Rapoport
Thyrotropin receptor cleavage at site 1 does not involve a specific amino acid motif but instead depends on the presence of the unique, 50 amino acid insertion.
The Journal of biological chemistry 1998;273(4):1959-63.
1997: Ayumu Kakinuma; Gregorio Chazenbalk; K Tanaka; Yuji Nagayama; Sandra M McLachlan; Basil Rapoport
An N-linked glycosylation motif from the noncleaving luteinizing hormone receptor substituted for the homologous region (Gly367 to Glu369) of the thyrotropin receptor prevents cleavage at its second, downstream site.
The Journal of biological chemistry 1997;272(45):28296-300.
1997: Juan Carlos Jaume; J Guo; Ayumu Kakinuma; Basil Rapoport; Sandra M McLachlan
The epitopic "fingerprint" of thyroid peroxidase-specific Fab isolated from a patient's thyroid gland by the combinatorial library approach resembles that of autoantibodies in the donor's serum.
Clinical immunology and immunopathology 1997;84(2):150-7.
1997: Gregorio Chazenbalk; Juan Carlos Jaume; Sandra M McLachlan; Basil Rapoport
Engineering the human thyrotropin receptor ectodomain from a non-secreted form to a secreted, highly immunoreactive glycoprotein that neutralizes autoantibodies in Graves' patients' sera.
The Journal of biological chemistry 1997;272(30):18959-65.
1997: Ayumu Kakinuma; Gregorio Chazenbalk; Juan Carlos Jaume; Basil Rapoport; Sandra M McLachlan
The human thyrotropin (TSH) receptor in a TSH binding inhibition assay for TSH receptor autoantibodies.
The Journal of clinical endocrinology and metabolism 1997;82(7):2129-34.
1997: Gregorio Chazenbalk; K Tanaka; Yuji Nagayama; Ayumu Kakinuma; Juan Carlos Jaume; Sandra M McLachlan; Basil Rapoport
Evidence that the thyrotropin receptor ectodomain contains not one, but two, cleavage sites.
Endocrinology 1997;138(7):2893-9.
1997: J Guo; Juan Carlos Jaume; Basil Rapoport; Sandra M McLachlan
Recombinant thyroid peroxidase-specific Fab converted to immunoglobulin G (IgG) molecules: evidence for thyroid cell damage by IgG1, but not IgG4, autoantibodies.
The Journal of clinical endocrinology and metabolism 1997;82(3):925-31.
1997: Juan Carlos Jaume; Ayumu Kakinuma; Gregorio Chazenbalk; Basil Rapoport; Sandra M McLachlan
Thyrotropin receptor autoantibodies in serum are present at much lower levels than thyroid peroxidase autoantibodies: analysis by flow cytometry.
The Journal of clinical endocrinology and metabolism 1997;82(2):500-7.
1997: J Guo; Basil Rapoport; Sandra M McLachlan
Thyroid peroxidase autoantibodies of IgE class in thyroid autoimmunity.
Clinical immunology and immunopathology 1997;82(2):157-62.
1997: J Guo; Basil Rapoport; Sandra M McLachlan
Cytokine profiles of in vivo activated thyroid-infiltrating T cells cloned in the presence or absence of interleukin 4.
Autoimmunity 1997;26(2):103-10.
1997: Ayumu Kakinuma; S Portolano; Gregorio Chazenbalk; Basil Rapoport; Sandra M McLachlan
Insight into screening immunoglobulin gene combinatorial libraries in a phage display vector: a tale of two antibodies.
Autoimmunity 1997;25(2):73-84.
1996: Gregorio Chazenbalk; Ayumu Kakinuma; Juan Carlos Jaume; Sandra M McLachlan; Basil Rapoport
Evidence for negative cooperativity among human thyrotropin receptors overexpressed in mammalian cells.
Endocrinology 1996;137(11):4586-91.
1996: J Guo; Sonia Quaratino; Juan Carlos Jaume; G Costante; M Londei; Sandra M McLachlan; Basil Rapoport
Autoantibody-mediated capture and presentation of autoantigen to T cells via the Fc epsilon receptor by a recombinant human autoantibody Fab converted to IgE.
Journal of immunological methods 1996;195(1-2):81-92.
1996: Gregorio Chazenbalk; Sandra M McLachlan; Y Nagayama; Basil Rapoport
Is receptor cleavage into two subunits necessary for thyrotropin action?
Biochemical and biophysical research communications 1996;225(2):479-84.
1996: Ayumu Kakinuma; Gregorio Chazenbalk; Sebastiano Filetti; Sandra M McLachlan; Basil Rapoport
Both the 5' and 3' noncoding regions of the thyrotropin receptor messenger ribonucleic acid influence the level of receptor protein expression in transfected mamalian cells.
Endocrinology 1996;137(7):2664-9.
1996: Basil Rapoport; Sandra M McLachlan; Ayumu Kakinuma; Gregorio Chazenbalk
Critical relationship between autoantibody recognition and thyrotropin receptor maturation as reflected in the acquisition of complex carbohydrate.
The Journal of clinical endocrinology and metabolism 1996;81(7):2525-33.
1996: Juan Carlos Jaume; CAROL BUREK; W H Hoffman; Noel R Rose; Sandra M McLachlan; Basil Rapoport
Thyroid peroxidase autoantibody epitopic 'fingerprints' in juvenile Hashimoto's thyroiditis: evidence for conservation over time and in families.
Clinical and experimental immunology 1996;104(1):115-23.
1996: T Nishikawa; Basil Rapoport; Sandra M McLachlan
The quest for the autoantibody immunodominant region on thyroid peroxidase: guided mutagenesis based on a hypothetical three-dimensional model.
Endocrinology 1996;137(3):1000-6.
1996: Juan Carlos Jaume; S Portolano; Basil Rapoport; Sandra M McLachlan
Influence of the light chain repertoire on immunoglobulin genes encoding thyroid autoantibody Fab from combinatorial libraries.
Autoimmunity 1996;24(1):11-23.
1995: S Portolano; M F Prummel; Basil Rapoport; Sandra M McLachlan
Molecular cloning and characterization of human thyroid peroxidase autoantibodies of lambda light chain type.
Molecular immunology 1995;32(14-15):1157-69.
1995: Sandra M McLachlan; Basil Rapoport
Genetic and epitopic analysis of thyroid peroxidase (TPO) autoantibodies: markers of the human thyroid autoimmune response.
Clinical and experimental immunology 1995;101(2):200-6.
1995: T Nishikawa; Juan Carlos Jaume; Sandra M McLachlan; Basil Rapoport
Human monoclonal autoantibodies against the immunodominant region on thyroid peroxidase: lack of cross-reactivity with related peroxidases or thyroglobulin and inability to inhibit thyroid peroxidase enzymatic activity.
The Journal of clinical endocrinology and metabolism 1995;80(4):1461-6.
1995: Juan Carlos Jaume; G Costante; T Nishikawa; David Phillips; Basil Rapoport; Sandra M McLachlan
Thyroid peroxidase autoantibody fingerprints in hypothyroid and euthyroid individuals. I. Cross-sectional study in elderly women.
The Journal of clinical endocrinology and metabolism 1995;80(3):994-9.
1995: Juan Carlos Jaume; A B Parkes; J H Lazarus; R Hall; G Costante; Sandra M McLachlan; Basil Rapoport
Thyroid peroxidase autoantibody fingerprints. II. A longitudinal study in postpartum thyroiditis.
The Journal of clinical endocrinology and metabolism 1995;80(3):1000-5.
1995: Basil Rapoport; S Portolano; Sandra M McLachlan
Combinatorial libraries: new insights into human organ-specific autoantibodies.
Immunology today 1995;16(1):43-9.
1994: T Nishikawa; Basil Rapoport; Sandra M McLachlan
Exclusion of two major areas on thyroid peroxidase from the immunodominant region containing the conformational epitopes recognized by human autoantibodies.
The Journal of clinical endocrinology and metabolism 1994;79(6):1648-54.
1994: M F Prummel; Gregorio Chazenbalk; Juan Carlos Jaume; Basil Rapoport; Sandra M McLachlan
Profile of lambda light chain variable region genes in Graves' orbital tissue.
Molecular immunology 1994;31(11):793-802.
1994: Juan Carlos Jaume; G Costante; S Portolano; Sandra M McLachlan; Basil Rapoport
Recombinant thyroid peroxidase-specific autoantibodies. I. How diverse is the pool of heavy and light chains in immunoglobulin gene libraries constructed from thyroid tissue-infiltrating plasma cells.
Endocrinology 1994;135(1):16-24.
1994: G Costante; S Portolano; T Nishikawa; Juan Carlos Jaume; Gregorio Chazenbalk; Basil Rapoport; Sandra M McLachlan
Recombinant thyroid peroxidase-specific autoantibodies. II. Role of individual heavy and light chains in determining epitope recognition.
Endocrinology 1994;135(1):25-30.
1994: M F Prummel; S Portolano; G Costante; Basil Rapoport; Sandra M McLachlan
Isolation and characterization of a monoclonal human thyroid peroxidase autoantibody of lambda light chain type.
Molecular and cellular endocrinology 1994;102(1-2):161-6.
1994: Sandra M McLachlan; M F Prummel; Basil Rapoport
Cell-mediated or humoral immunity in Graves' ophthalmopathy? Profiles of T-cell cytokines amplified by polymerase chain reaction from orbital tissue.
The Journal of clinical endocrinology and metabolism 1994;78(5):1070-4.
1994: Sandra M McLachlan; M F Prummel; Juan Carlos Jaume; Basil Rapoport
Immunoglobulin A in Graves' orbital tissue: deoxyribonucleic acid amplification by polymerase chain reaction.
Journal of endocrinological investigation 1994;17(4):247-52.
1994: T Nishikawa; G Costante; M F Prummel; Sandra M McLachlan; Basil Rapoport
Recombinant thyroid peroxidase autoantibodies can be used for epitopic "fingerprinting" of thyroid peroxidase autoantibodies in the sera of individual patients.
The Journal of clinical endocrinology and metabolism 1994;78(4):944-9.
1994: Juan Carlos Jaume; S Portolano; M F Prummel; Sandra M McLachlan; Basil Rapoport
Molecular cloning and characterization of genes for antibodies generated by orbital tissue-infiltrating B-cells in Graves' ophthalmopathy.
The Journal of clinical endocrinology and metabolism 1994;78(2):348-52.
1993: Gregorio Chazenbalk; G Costante; S Portolano; Sandra M McLachlan; Basil Rapoport
The immunodominant region on human thyroid peroxidase recognized by autoantibodies does not contain the monoclonal antibody 47/c21 linear epitope.
The Journal of clinical endocrinology and metabolism 1993;77(6):1715-8.
1993: Sandra M McLachlan; Basil Rapoport
Recombinant thyroid autoantigens: the keys to the pathogenesis of autoimmune thyroid disease.
Journal of internal medicine 1993;234(4):347-59.
1993: S Portolano; Sandra M McLachlan; Basil Rapoport
High affinity, thyroid-specific human autoantibodies displayed on the surface of filamentous phage use V genes similar to other autoantibodies.
Journal of immunology (Baltimore, Md. : 1950) 1993;151(5):2839-51.
1993: P Seto; Y Nagayama; D Foti; Sandra M McLachlan; Basil Rapoport
Autoantibodies in the sera of patients with autoimmune thyroid disease recognize a secreted form of human thyroid peroxidase generated in a baculovirus system.
Molecular and cellular endocrinology 1993;94(1):R5-8.
1993: Gregorio Chazenbalk; S Portolano; D Russo; J S Hutchison; Basil Rapoport; Sandra M McLachlan
Human organ-specific autoimmune disease. Molecular cloning and expression of an autoantibody gene repertoire for a major autoantigen reveals an antigenic immunodominant region and restricted immunoglobulin gene usage in the target organ.
The Journal of clinical investigation 1993;92(1):62-74.
1993: S Portolano; Gregorio Chazenbalk; J S Hutchison; Sandra M McLachlan; Basil Rapoport
Lack of promiscuity in autoantigen-specific H and L chain combinations as revealed by human H and L chain "roulette".
Journal of immunology (Baltimore, Md. : 1950) 1993;150(3):880-7.
1993: Juan Carlos Jaume; M F Prummel; W M Wiersinga; Sandra M McLachlan; Basil Rapoport
Thyrotropin receptor autoantibodies recognizing two different epitopes on the TSH receptor: lack of relationship to patient age, sex, and ophthalmopathy.
Thyroid : official journal of the American Thyroid Association 1993;3(4):291-5.
1992: S Portolano; Gregorio Chazenbalk; P Seto; J S Hutchison; Basil Rapoport; Sandra M McLachlan
Recognition by recombinant autoimmune thyroid disease-derived Fab fragments of a dominant conformational epitope on human thyroid peroxidase.
The Journal of clinical investigation 1992;90(3):720-6.
1992: Sandra M McLachlan; Basil Rapoport
The molecular biology of thyroid peroxidase: cloning, expression and role as autoantigen in autoimmune thyroid disease.
Endocrine reviews 1992;13(2):192-206.
1992: Sandra M McLachlan; R Bahn; Basil Rapoport
Endocrine ophthalmopathy: a re-evaluation of the association with thyroid autoantibodies.
Autoimmunity 1992;14(2):143-8.
1991: S Portolano; P Seto; Gregorio Chazenbalk; Y Nagayama; Sandra M McLachlan; Basil Rapoport
A human Fab fragment specific for thyroid peroxidase generated by cloning thyroid lymphocyte-derived immunoglobulin genes in a bacteriophage lambda library.
Biochemical and biophysical research communications 1991;179(1):372-7.