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Pamela McLean

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TOP 3
Lorraine V Kalia; Suneil K Kalia; Andres M Lozano; Pamela J McLean; Anthony E Lang
α-Synuclein oligomers and clinical implications for Parkinson disease.
Darius Ebrahimi-Fakhari; Lara Wahlster; Pamela J McLean
Protein degradation pathways in Parkinson's disease: curse or blessing.
Darius Ebrahimi-Fakhari; Pamela J McLean; Vivek K Unni
Alpha-synuclein's degradation in vivo: opening a new (cranial) window on the roles of degradation pathways in Parkinson disease.

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All Publications

2013: Lorraine V Kalia; Suneil K Kalia; Andres M Lozano; Pamela J McLean; Anthony E Lang
α-Synuclein oligomers and clinical implications for Parkinson disease.
Annals of neurology 2013;73(2):155-69.
2012: Darius Ebrahimi-Fakhari; Lara Wahlster; Pamela J McLean
Protein degradation pathways in Parkinson's disease: curse or blessing.
Acta neuropathologica 2012;124(2):153-72.
2012: Darius Ebrahimi-Fakhari; Pamela J McLean; Vivek K Unni
Alpha-synuclein's degradation in vivo: opening a new (cranial) window on the roles of degradation pathways in Parkinson disease.
Autophagy 2012;8(2):281-3.
2012: Karin M Danzer; Lisa R Kranich; Ozge Cagsal-Getkin; Wolfgang P Ruf; Charles R Vanderburg; Ashley R Winslow; Liya Zhu; Pamela J McLean
Exosomal cell-to-cell transmission of alpha synuclein oligomers.
Molecular neurodegeneration 2012;7():42.
2011: Darius Ebrahimi-Fakhari; Zhanyun Fan; Bradley T Hyman; Eliezer Masliah; Pamela J McLean; Edward Rockenstein; Ippolita Cantuti-Castelvetri; Vivek K Unni
Distinct roles in vivo for the ubiquitin-proteasome system and the autophagy-lysosomal pathway in the degradation of α-synuclein.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2011;31(41):14508-20.
2011: Karin M Danzer; Pamela J McLean
Drug targets from genetics: alpha-synuclein.
CNS & neurological disorders drug targets 2011;10(6):712-23.
2011: Joseph R Mazzulli; Pamela J McLean; Ellen Sidransky; Ying Sun; You-Hai Xu; Guy A Caldwell; Gregory A Grabowski; Adam L Knight; Dimitri Krainc
Gaucher disease glucocerebrosidase and α-synuclein form a bidirectional pathogenic loop in synucleinopathies.
Cell 2011;146(1):37-52.
2011: Vivek K Unni; Darius Ebrahimi-Fakhari; Charles R Vanderburg; Pamela J McLean; Bradley T Hyman
Studying protein degradation pathways in vivo using a cranial window-based approach.
Methods (San Diego, Calif.) 2011;53(3):194-200.
2011: Lorraine V Kalia; Suneil K Kalia; Hien Chau; Andres M Lozano; Bradley T Hyman; Pamela J McLean
Ubiquitinylation of α-synuclein by carboxyl terminus Hsp70-interacting protein (CHIP) is regulated by Bcl-2-associated athanogene 5 (BAG5).
PloS one 2011;6(2):e14695.
2011: Karin M Danzer; Wolfgang P Ruf; Preeti Putcha; Daniel Joyner; Tadafumi Hashimoto; Charles G Glabe; Bradley T Hyman; Pamela J McLean
Heat-shock protein 70 modulates toxic extracellular α-synuclein oligomers and rescues trans-synaptic toxicity.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2011;25(1):326-36.
2010: S K Kalia; L V Kalia; Pamela J McLean
Molecular chaperones as rational drug targets for Parkinson's disease therapeutics.
CNS & neurological disorders drug targets 2010;9(6):741-53.
2010: Preeti Putcha; Karin M Danzer; Lisa R Kranich; Anisa Scott; Melanie Silinski; Sarah Mabbett; Carol D Hicks; James M Veal; Paul M Steed; Bradley T Hyman; Pamela J McLean
Brain-permeable small-molecule inhibitors of Hsp90 prevent alpha-synuclein oligomer formation and rescue alpha-synuclein-induced toxicity.
The Journal of pharmacology and experimental therapeutics 2010;332(3):849-57.
2010: Vivek K Unni; Tamily A Weissman; Edward Rockenstein; Eliezer Masliah; Pamela J McLean; Bradley T Hyman
In vivo imaging of alpha-synuclein in mouse cortex demonstrates stable expression and differential subcellular compartment mobility.
PloS one 2010;5(5):e10589.
2009: Nikolaus R McFarland; Zhanyun Fan; Kui Xu; Michael A Schwarzschild; Mel B Feany; Bradley T Hyman; Pamela J McLean
Alpha-synuclein S129 phosphorylation mutants do not alter nigrostriatal toxicity in a rat model of Parkinson disease.
Journal of neuropathology and experimental neurology 2009;68(5):515-24.
2009: Nikolaus R McFarland; Jeng-Shin Lee; Bradley T Hyman; Pamela J McLean
Comparison of transduction efficiency of recombinant AAV serotypes 1, 2, 5, and 8 in the rat nigrostriatal system.
Journal of neurochemistry 2009;109(3):838-45.
2009: Tiago Outeiro; Jochen Klucken; Kathryn Bercury; Julie Tetzlaff; Preeti Putcha; Luis M A Oliveira; Alexandre Quintas; Pamela J McLean; Bradley T Hyman
Dopamine-induced conformational changes in alpha-synuclein.
PloS one 2009;4(9):e6906.
2008: Shaji Theodore; Shuwen Cao; Pamela J McLean; David G Standaert
Targeted overexpression of human alpha-synuclein triggers microglial activation and an adaptive immune response in a mouse model of Parkinson disease.
Journal of neuropathology and experimental neurology 2008;67(12):1149-58.
2008: Julie E Tetzlaff; Preeti Putcha; Tiago Outeiro; Alexander Ivanov; Oksana Berezovska; Bradley T Hyman; Pamela J McLean
CHIP targets toxic alpha-Synuclein oligomers for degradation.
The Journal of biological chemistry 2008;283(26):17962-8.
2008: Talene A Yacoubian; Ippolita Cantuti-Castelvetri; Bérengère Bouzou; Georgios Asteris; Pamela J McLean; Bradley T Hyman; David G Standaert
Transcriptional dysregulation in a transgenic model of Parkinson disease.
Neurobiology of disease 2008;29(3):515-28.
2008: Tiago Outeiro; Preeti Putcha; Julie E Tetzlaff; Robert Spoelgen; Mirjam Koker; Filipe Carvalho; Bradley T Hyman; Pamela J McLean
Formation of toxic oligomeric alpha-synuclein species in living cells.
PloS one 2008;3(4):e1867.
2007: Tiago Outeiro; Eirene Kontopoulos; Stephen M Altmann; Irina Kufareva; Katherine E Strathearn; Allison M Amore; Catherine B Volk; Michele M Maxwell; Jean-Christophe Rochet; Pamela J McLean; Anne B Young; Ruben Abagyan; Mel B Feany; Bradley T Hyman; Aleksey G Kazantsev
Sirtuin 2 inhibitors rescue alpha-synuclein-mediated toxicity in models of Parkinson's disease.
Science (New York, N.Y.) 2007;317(5837):516-9.
2007: Jessie L St Martin; Jochen Klucken; Tiago Outeiro; Paul Nguyen; Christine Keller-McGandy; Ippolita Cantuti-Castelvetri; Tom N Grammatopoulos; David G Standaert; Bradley T Hyman; Pamela J McLean
Dopaminergic neuron loss and up-regulation of chaperone protein mRNA induced by targeted over-expression of alpha-synuclein in mouse substantia nigra.
Journal of neurochemistry 2007;100(6):1449-57.
2006: Tiago Outeiro; Jochen Klucken; Katherine E Strathearn; Fang Liu; Paul Nguyen; Jean-Christophe Rochet; Bradley T Hyman; Pamela J McLean
Small heat shock proteins protect against alpha-synuclein-induced toxicity and aggregation.
Biochemical and biophysical research communications 2006;351(3):631-8.
2006: Jochen Klucken; Tiago Outeiro; Paul Nguyen; Pamela J McLean; Bradley T Hyman
Detection of novel intracellular alpha-synuclein oligomeric species by fluorescence lifetime imaging.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2006;20(12):2050-7.
2006: Ruth A Bodner; Tiago Outeiro; Stephen M Altmann; Michele M Maxwell; Stephanie H Cho; Bradley T Hyman; Pamela J McLean; Anne B Young; David E Housman; Aleksey G Kazantsev
Pharmacological promotion of inclusion formation: a therapeutic approach for Huntington's and Parkinson's diseases.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(11):4246-51.
2006: Jochen Klucken; Martin Ingelsson; Youngah Shin; Michael C Irizarry; E Tessa Hedley-Whyte; M Frosch; John H Growdon; Pamela J McLean; Bradley T Hyman
Clinical and biochemical correlates of insoluble alpha-synuclein in dementia with Lewy bodies.
Acta neuropathologica 2006;111(2):101-8.
2005: Ippolita Cantuti-Castelvetri; Jochen Klucken; Martin Ingelsson; Karunya Ramasamy; Pamela J McLean; Matthew P Frosch; Bradley T Hyman; David G Standaert
Alpha-synuclein and chaperones in dementia with Lewy bodies.
Journal of neuropathology and experimental neurology 2005;64(12):1058-66.
2005: Tara L Spires; Melanie Meyer-Luehmann; Edward A Stern; Pamela J McLean; Jesse Skoch; Paul T Nguyen; Brian J Bacskai; Bradley T Hyman
Dendritic spine abnormalities in amyloid precursor protein transgenic mice demonstrated by gene transfer and intravital multiphoton microscopy.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2005;25(31):7278-87.
2005: Youngah Shin; Jochen Klucken; Winston Patterson; Bradley T Hyman; Pamela J McLean
The co-chaperone carboxyl terminus of Hsp70-interacting protein (CHIP) mediates alpha-synuclein degradation decisions between proteasomal and lysosomal pathways.
The Journal of biological chemistry 2005;280(25):23727-34.
2004: Jochen Klucken; Youngah Shin; Bradley T Hyman; Pamela J McLean
A single amino acid substitution differentiates Hsp70-dependent effects on alpha-synuclein degradation and toxicity.
Biochemical and biophysical research communications 2004;325(1):367-73.
2004: Pamela J McLean; Jochen Klucken; Youngah Shin; Bradley T Hyman
Geldanamycin induces Hsp70 and prevents alpha-synuclein aggregation and toxicity in vitro.
Biochemical and biophysical research communications 2004;321(3):665-9.
2004: Jochen Klucken; Youngah Shin; Eliezer Masliah; Bradley T Hyman; Pamela J McLean
Hsp70 Reduces alpha-Synuclein Aggregation and Toxicity.
The Journal of biological chemistry 2004;279(24):25497-502.
2003: Jochen Klucken; Pamela J McLean; E Gomez-Tortosa; Martin Ingelsson; Bradley T Hyman
Neuritic alterations and neural system dysfunction in Alzheimer's disease and dementia with Lewy bodies.
Neurochemical research 2003;28(11):1683-91.
2002: Pamela J McLean; Hibiki Kawamata; Saadat Shariff; Jeffrey W Hewett; Nutan Sharma; Kenji Ueda; Xandra O Breakefield; Bradley T Hyman
TorsinA and heat shock proteins act as molecular chaperones: suppression of alpha-synuclein aggregation.
Journal of neurochemistry 2002;83(4):846-54.
2002: Pamela J McLean; Bradley T Hyman
An alternatively spliced form of rodent alpha-synuclein forms intracellular inclusions in vitro: role of the carboxy-terminus in alpha-synuclein aggregation.
Neuroscience letters 2002;323(3):219-23.
2001: Nutan Sharma; Pamela J McLean; Hibiki Kawamata; Michael C Irizarry; Bradley T Hyman
Alpha-synuclein has an altered conformation and shows a tight intermolecular interaction with ubiquitin in Lewy bodies.
Acta neuropathologica 2001;102(4):329-34.
2001: N Sharma; Jeffrey W Hewett; Laurie J Ozelius; Vijaya Ramesh; Pamela J McLean; Xandra O Breakefield; Bradley T Hyman
A close association of torsinA and alpha-synuclein in Lewy bodies: a fluorescence resonance energy transfer study.
The American journal of pathology 2001;159(1):339-44.
2001: Hibiki Kawamata; Pamela J McLean; Nutan Sharma; Bradley T Hyman
Interaction of alpha-synuclein and synphilin-1: effect of Parkinson's disease-associated mutations.
Journal of neurochemistry 2001;77(3):929-34.
2001: Pamela J McLean; Hibiki Kawamata; Bradley T Hyman
Alpha-synuclein-enhanced green fluorescent protein fusion proteins form proteasome sensitive inclusions in primary neurons.
Neuroscience 2001;104(3):901-12.
2000: Oksana Berezovska; Christine Jack; Pamela J McLean; Jon C Aster; C Hicks; Weiming Xia; Michael S Wolfe; W Taylor Kimberly; G Weinmaster; Dennis J Selkoe; Bradley T Hyman
Aspartate mutations in presenilin and gamma-secretase inhibitors both impair notch1 proteolysis and nuclear translocation with relative preservation of notch1 signaling.
Journal of neurochemistry 2000;75(2):583-93.
2000: Pamela J McLean; Hibiki Kawamata; S Ribich; Bradley T Hyman
Membrane association and protein conformation of alpha-synuclein in intact neurons. Effect of Parkinson's disease-linked mutations.
The Journal of biological chemistry 2000;275(12):8812-6.
2000: Oksana Berezovska; Christine Jack; Pamela J McLean; Jon C Aster; C Hicks; Weiming Xia; Michael S Wolfe; G Weinmaster; Dennis J Selkoe; Bradley T Hyman
Rapid Notch1 nuclear translocation after ligand binding depends on presenilin-associated gamma-secretase activity.
Annals of the New York Academy of Sciences 2000;920():223-6.
2000: Pamela J McLean; S Ribich; Bradley T Hyman
Subcellular localization of alpha-synuclein in primary neuronal cultures: effect of missense mutations.
Journal of neural transmission. Supplementum 2000;(58):53-63.
1999: Oksana Berezovska; M Frosch; Pamela J McLean; R Knowles; Edward H Koo; David E Kang; Jie Shen; F M Lu; Samuel E Lux; Susumu Tonegawa; Bradley T Hyman
The Alzheimer-related gene presenilin 1 facilitates notch 1 in primary mammalian neurons.
Brain research. Molecular brain research 1999;69(2):273-80.
1999: Oksana Berezovska; Pamela J McLean; R Knowles; M Frosh; F M Lu; Samuel E Lux; Bradley T Hyman
Notch1 inhibits neurite outgrowth in postmitotic primary neurons.
Neuroscience 1999;93(2):433-9.