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Andrew McMahon

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Physiology

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Yana G Kamberov; Shilin Li; Daniel E Lieberman; Jason Lohmueller; Junhao Mao; Andrew P McMahon; Bruce A Morgan; Madeline Paymer; Adam Powell; Melissa Burnett; Elizabeth Byrne; Hua Chen; Dorian Fuller; Pascale Gerbault; Elizabeth Hostetter; Yuval Itan; Li Jin; Asa Schachar; Clifford J Tabin; Jingze Tan; Longzhi Tan; Kun Tang; Mark Thomas; Sijia Wang; Abigail Wark; Yajun Yang; Pardis C Sabeti
Modeling recent human evolution in mice by expression of a selected EDAR variant.
Kevin A Peterson; Leila Shokri; Alexander van Oudenaarden; Anastasia Vedenko; Wing H Wong; Xiaoxiao Zhang; Tarjei Mikkelsen; Yuichi Nishi; Timothy Lawrence Bailey; José-Manuel Baizabal; Bradley E Bernstein; Martha L Bulyk; Jan Philipp Junker; Wenxiu Ma; Matthew McFarlane; Andrew P McMahon
Neural-specific Sox2 input and differential Gli-binding affinity provide context and positional information in Shh-directed neural patterning.
Joo-Seop Park; Michael T Valerius; Wing Hung Wong; Jill A McMahon; Lori L O'Brien; Jr-Gang Cheng; Eunah Chung; Jin-Jin Guo; Wenxiu Ma; Andrew P McMahon
Six2 and Wnt regulate self-renewal and commitment of nephron progenitors through shared gene regulatory networks.

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All Publications

2013: Yana G Kamberov; Shilin Li; Daniel E Lieberman; Jason Lohmueller; Junhao Mao; Andrew P McMahon; Bruce A Morgan; Madeline Paymer; Adam Powell; Melissa Burnett; Elizabeth Byrne; Hua Chen; Dorian Fuller; Pascale Gerbault; Elizabeth Hostetter; Yuval Itan; Li Jin; Asa Schachar; Clifford J Tabin; Jingze Tan; Longzhi Tan; Kun Tang; Mark Thomas; Sijia Wang; Abigail Wark; Yajun Yang; Pardis C Sabeti
Modeling recent human evolution in mice by expression of a selected EDAR variant.
Cell 2013;152(4):691-702.
2012: Kevin A Peterson; Leila Shokri; Alexander van Oudenaarden; Anastasia Vedenko; Wing H Wong; Xiaoxiao Zhang; Tarjei Mikkelsen; Yuichi Nishi; Timothy Lawrence Bailey; José-Manuel Baizabal; Bradley E Bernstein; Martha L Bulyk; Jan Philipp Junker; Wenxiu Ma; Matthew McFarlane; Andrew P McMahon
Neural-specific Sox2 input and differential Gli-binding affinity provide context and positional information in Shh-directed neural patterning.
Genes & development 2012;26(24):2802-16.
2012: Joo-Seop Park; Michael T Valerius; Wing Hung Wong; Jill A McMahon; Lori L O'Brien; Jr-Gang Cheng; Eunah Chung; Jin-Jin Guo; Wenxiu Ma; Andrew P McMahon
Six2 and Wnt regulate self-renewal and commitment of nephron progenitors through shared gene regulatory networks.
Developmental cell 2012;23(3):637-51.
2012: Yu Wang; Ke Xu; Jin Woo Yoo; Jessica M Y Ng; Vatsal Oza; Lee L Rubin; Anthony C Arvanites; Joel Blanchard; Tom Curran; Lance Davidow; Kelvin Lam; Andrew P McMahon
Glucocorticoid compounds modify smoothened localization and hedgehog pathway activity.
Chemistry & biology 2012;19(8):972-82.
2012: Yu Wang; Jin Woo Yoo; Lee L Rubin; Anthony C Arvanites; Joel Blanchard; Shannon Coy; Lance Davidow; Kelvin Lam; Andrew P McMahon
Selective identification of hedgehog pathway antagonists by direct analysis of smoothened ciliary translocation.
ACS chemical biology 2012;7(6):1040-8.
2012: Melissa H Little; Andrew P McMahon
Mammalian kidney development: principles, progress, and projections.
Cold Spring Harbor perspectives in biology 2012;4(5):.
2012: Jing Yu; Timothy Lawrence Bailey; Mary Duah; Diane Faria; Kylie Georgas; Paul A Gray; Sean M Grimmond; Jin-Jin Guo; Jennifer K Hansard; Jan P Junker; A Michaela Krautzberger; Melissa H Little; Qiufu Ma; Philip Machanick; Jill McMahon; Qun Ren; David H Rowitch; Bree Rumballe; Karl Staser; Charles D Stiles; Rathi D Thiagarajan; Michael T Valerius; Alexander van Oudenaarden; Joe Vaughan; Andrew P McMahon
Identification of molecular compartments and genetic circuitry in the developing mammalian kidney.
Development (Cambridge, England) 2012;139(10):1863-73.
2012: Kaloyan M Tsanov; Manfred Baetscher; Jing Liu; Yuichi Nishi; Kevin A Peterson; Andrew P McMahon
An embryonic stem cell-based system for rapid analysis of transcriptional enhancers.
Genesis (New York, N.Y. : 2000) 2012;50(5):443-50.
2012: Carrie B Wiese; Jing Yu; M Todd Valerius; Jane Armstrong; Jane Brennan; Han Sheng Chiu; Nicole L Fleming; Kylie Georgas; Sara Ireland; Melissa H Little; Andrew P McMahon; E Michelle Southard-Smith
A genome-wide screen to identify transcription factors expressed in pelvic Ganglia of the lower urinary tract.
Frontiers in neuroscience 2012;6():130.
2011: Simon D Harding; Derek Houghton; Melissa H Little; Sue Lloyd-MacGilp; Andrew P McMahon; Cathy Mendelsohn; Xingjun Pi; steven potter; Yogmatee Roochun; Mehran Sharghi; E Michelle Southard-Smith; Christopher Tindal; Chris Armit; Jane Armstrong; Bruce J Aronow; Richard Baldock; Jane Brennan; Eric W Brunskill; Ying Cheng; Jamie Andrew Davies; Kylie Georgas; Brian Gottesman; Bernard Haggarty; Duncan Davidson
The GUDMAP database--an online resource for genitourinary research.
Development (Cambridge, England) 2011;138(13):2845-53.
2011: Benjamin Allen; Irene W Althaus; Frédéric Charron; Luisa Izzi; Jong-Sun Kang; Robert S Krauss; Jane Y Song; Andrew P McMahon
Overlapping roles and collective requirement for the coreceptors GAS1, CDO, and BOC in SHH pathway function.
Developmental cell 2011;20(6):775-87.
2010: Kathy K Niakan; Hongkai Ji; Rene Maehr; Steven A Vokes; Kit T Rodolfa; Richard I Sherwood; Mariko Yamaki; John T Dimos; Alice E Chen; Douglas A Melton; Andrew P McMahon; Kevin Eggan
Sox17 promotes differentiation in mouse embryonic stem cells by directly regulating extraembryonic gene expression and indirectly antagonizing self-renewal.
Genes & development 2010;24(3):312-26.
2009: Charisios Tsiairis; Andrew P McMahon
An Hh-dependent pathway in lateral plate mesoderm enables the generation of left/right asymmetry.
Current biology : CB 2009;19(22):1912-7.
2009: Joshua Mugford; Jing Yu; Akio Kobayashi; Andrew P McMahon
High-resolution gene expression analysis of the developing mouse kidney defines novel cellular compartments within the nephron progenitor population.
Developmental biology 2009;333(2):312-23.
2009: Kylie Georgas; Bree Rumballe; Michael T Valerius; Han Sheng Chiu; Rathi D Thiagarajan; Emmanuelle Lesieur; Bruce Aronow; Eric W Brunskill; Alexander N Combes; Dave Tang; Darrin Taylor; Sean M Grimmond; steven potter; Andrew P McMahon; Melissa H Little
Analysis of early nephron patterning reveals a role for distal RV proliferation in fusion to the ureteric tip via a cap mesenchyme-derived connecting segment.
Developmental biology 2009;332(2):273-86.
2009: Yuichi Nishi; Hongkai Ji; Wing H Wong; Andrew P McMahon; Steven A Vokes
Modeling the spatio-temporal network that drives patterning in the vertebrate central nervous system.
Biochimica et biophysica acta 2009;1789(4):299-305.
2009: junhao mao; Edwina McGlinn; Peng Huang; Clifford J Tabin; Andrew P McMahon
Fgf-dependent Etv4/5 activity is required for posterior restriction of Sonic Hedgehog and promoting outgrowth of the vertebrate limb.
Developmental cell 2009;16(4):600-6.
2009: Yu Wang; Zhe Zhou; Christopher T Walsh; Andrew P McMahon
Selective translocation of intracellular Smoothened to the primary cilium in response to Hedgehog pathway modulation.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(8):2623-8.
2009: Abhik Shah; Toyoaki Tenzen; Andrew P McMahon; Peter J Woolf
Using mechanistic Bayesian networks to identify downstream targets of the sonic hedgehog pathway.
BMC bioinformatics 2009;10():433.
2009: Jing Yu; Thomas J. Carroll; Jay Rajagopal; Akio Kobayashi; Qun Ren; Andrew P McMahon
A Wnt7b-dependent pathway regulates the orientation of epithelial cell division and establishes the cortico-medullary axis of the mammalian kidney.
Development (Cambridge, England) 2009;136(1):161-71.
2008: Joshua Mugford; Petra Sipilä; Jill A McMahon; Andrew P McMahon
Osr1 expression demarcates a multi-potent population of intermediate mesoderm that undergoes progressive restriction to an Osr1-dependent nephron progenitor compartment within the mammalian kidney.
Developmental biology 2008;324(1):88-98.
2008: Jan M Stenman; Jay Rajagopal; Thomas J. Carroll; Makoto Ishibashi; Jill McMahon; Andrew P McMahon
Canonical Wnt signaling regulates organ-specific assembly and differentiation of CNS vasculature.
Science (New York, N.Y.) 2008;322(5905):1247-50.
2008: Steven A Vokes; Hongkai Ji; Wing H Wong; Andrew P McMahon
A genome-scale analysis of the cis-regulatory circuitry underlying sonic hedgehog-mediated patterning of the mammalian limb.
Genes & development 2008;22(19):2651-63.
2008: Ulrich Schüller; Vivi M Heine; junhao mao; Alvin T Kho; Allison K Dillon; Young-Goo Han; Emmanuelle Huillard; Tao Sun; Azra H Ligon; Ying Qian; Qiufu Ma; Arturo Alvarez-Buylla; Andrew P McMahon; David H Rowitch; Keith L Ligon
Acquisition of granule neuron precursor identity is a critical determinant of progenitor cell competence to form Shh-induced medulloblastoma.
Cancer cell 2008;14(2):123-34.
2008: Akio Kobayashi; Michael T Valerius; Joshua Mugford; Thomas J. Carroll; Michelle Self; Guillermo Oliver; Andrew P McMahon
Six2 defines and regulates a multipotent self-renewing nephron progenitor population throughout mammalian kidney development.
Cell stem cell 2008;3(2):169-81.
2008: Zhe Zhou; Alexander Koglin; Yu Wang; Andrew P McMahon; Christopher T Walsh
An eight residue fragment of an acyl carrier protein suffices for post-translational introduction of fluorescent pantetheinyl arms in protein modification in vitro and in vivo.
Journal of the American Chemical Society 2008;130(30):9925-30.
2008: Masako Shimada; Peter A Greer; Andrew P McMahon; Mary L Bouxsein; Ernestina Schipani
In vivo targeted deletion of calpain small subunit, Capn4, in cells of the osteoblast lineage impairs cell proliferation, differentiation, and bone formation.
The Journal of biological chemistry 2008;283(30):21002-10.
2008: Clifford J Tabin; Andrew P McMahon
Developmental biology. Grasping limb patterning.
Science (New York, N.Y.) 2008;321(5887):350-2.
2008: Joshua Mugford; Petra Sipilä; Akio Kobayashi; Richard R Behringer; Andrew P McMahon
Hoxd11 specifies a program of metanephric kidney development within the intermediate mesoderm of the mouse embryo.
Developmental biology 2008;319(2):396-405.
2008: Carl R Walkley; Rameez Qudsi; Vijay G Sankaran; Jennifer A. Perry; Monica Gostissa; Sanford I Roth; Stephen J Rodda; Erin Snay; Patricia Dunning; Frederic H Fahey; Frederick W Alt; Andrew P McMahon; Stuart H Orkin
Conditional mouse osteosarcoma, dependent on p53 loss and potentiated by loss of Rb, mimics the human disease.
Genes & development 2008;22(12):1662-76.
2008: Charisios Tsiairis; Andrew P McMahon
Disp1 regulates growth of mammalian long bones through the control of Ihh distribution.
Developmental biology 2008;317(2):480-5.
2008: Jayaraj Rajagopal; Thomas J. Carroll; J Sawalla Guseh; Sam A Bores; Leah J Blank; William J Anderson; Jing Yu; Qiao Zhou; Andrew P McMahon; Douglas A Melton
Wnt7b stimulates embryonic lung growth by coordinately increasing the replication of epithelium and mesenchyme.
Development (Cambridge, England) 2008;135(9):1625-34.
2008: Michael T Valerius; Andrew P McMahon
Transcriptional profiling of Wnt4 mutant mouse kidneys identifies genes expressed during nephron formation.
Gene expression patterns : GEP 2008;8(5):297-306.
2008: Andrew P McMahon; Bruce Aronow; Duncan R Davidson; Jamie Andrew Davies; Kevin W Gaido; Sean M Grimmond; James L Lessard; Melissa H Little; steven potter; Elizabeth L Wilder; Pumin Zhang
GUDMAP: the genitourinary developmental molecular anatomy project.
Journal of the American Society of Nephrology : JASN 2008;19(4):667-71.
2008: Chester E Chamberlain; Juhee Jeong; Chaoshe Guo; Benjamin Allen; Andrew P McMahon
Notochord-derived Shh concentrates in close association with the apically positioned basal body in neural target cells and forms a dynamic gradient during neural patterning.
Development (Cambridge, England) 2008;135(6):1097-106.
2008: Tatsuya Kobayashi; Jun Lu; Bradley S Cobb; Stephen J Rodda; Andrew P McMahon; Ernestina Schipani; Matthias Merkenschlager; Henry M Kronenberg
Dicer-dependent pathways regulate chondrocyte proliferation and differentiation.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(6):1949-54.
2007: Jeffery R Barrow; William D Howell; Michael Rule; Shigemi Hayashi; Kirk R Thomas; Mario R Capecchi; Andrew P McMahon
Wnt3 signaling in the epiblast is required for proper orientation of the anteroposterior axis.
Developmental biology 2007;312(1):312-20.
2007: Wenlai Zhou; Lizhu Lin; Arindam Majumdar; Xue Li; Xiaoxue Zhang; Wei Liu; Leah Etheridge; Yunqing Shi; James Martin; Wim Van de Ven; Vesa Kaartinen; Anthony Wynshaw-Boris; Andrew P McMahon; Michael G Rosenfeld; Sylvia M Evans
Modulation of morphogenesis by noncanonical Wnt signaling requires ATF/CREB family-mediated transcriptional activation of TGFbeta2.
Nature genetics 2007;39(10):1225-34.
2007: Arhat Abzhanov; Stephen J Rodda; Andrew P McMahon; Clifford J Tabin
Regulation of skeletogenic differentiation in cranial dermal bone.
Development (Cambridge, England) 2007;134(17):3133-44.
2007: Joo-Seop Park; Michael T Valerius; Andrew P McMahon
Wnt/beta-catenin signaling regulates nephron induction during mouse kidney development.
Development (Cambridge, England) 2007;134(13):2533-9.
2007: Benjamin Allen; Toyoaki Tenzen; Andrew P McMahon
The Hedgehog-binding proteins Gas1 and Cdo cooperate to positively regulate Shh signaling during mouse development.
Genes & development 2007;21(10):1244-57.
2007: Steven A Vokes; Hongkai Ji; Scott McCuine; Toyoaki Tenzen; Shane Giles; Sheng Zhong; William J R Longabaugh; Eric H Davidson; Wing H Wong; Andrew P McMahon
Genomic characterization of Gli-activator targets in sonic hedgehog-mediated neural patterning.
Development (Cambridge, England) 2007;134(10):1977-89.
2007: Yu Wang; Andrew P McMahon; Benjamin Allen
Shifting paradigms in Hedgehog signaling.
Current opinion in cell biology 2007;19(2):159-65.
2007: Amel Gritli-Linde; Kristina Hallberg; Brian D Harfe; Azadeh Reyahi; Marie Kannius-Janson; Jeanette Nilsson; Martyn T Cobourne; Paul T Sharpe; Andrew P McMahon; Anders Linde
Abnormal hair development and apparent follicular transformation to mammary gland in the absence of hedgehog signaling.
Developmental cell 2007;12(1):99-112.
2006: junhao mao; Keith L Ligon; Elena Y Rakhlin; Sarah P Thayer; Roderick T Bronson; David H Rowitch; Andrew P McMahon
A novel somatic mouse model to survey tumorigenic potential applied to the Hedgehog pathway.
Cancer research 2006;66(20):10171-8.
2006: Stephen J Rodda; Andrew P McMahon
Distinct roles for Hedgehog and canonical Wnt signaling in specification, differentiation and maintenance of osteoblast progenitors.
Development (Cambridge, England) 2006;133(16):3231-44.
2006: Jing Yu; Andrew P McMahon
Reproducible and inducible knockdown of gene expression in mice.
Genesis (New York, N.Y. : 2000) 2006;44(5):252-61.
2006: Toyoaki Tenzen; Benjamin Allen; Francesca Cole; Jong-Sun Kang; Robert S Krauss; Andrew P McMahon
The cell surface membrane proteins Cdo and Boc are components and targets of the Hedgehog signaling pathway and feedback network in mice.
Developmental cell 2006;10(5):647-56.
2005: Kent Nybakken; Steven A Vokes; Ting-Yi Lin; Andrew P McMahon; Norbert Perrimon
A genome-wide RNA interference screen in Drosophila melanogaster cells for new components of the Hh signaling pathway.
Nature genetics 2005;37(12):1323-32.
2005: Mark Wijgerde; Seth Karp; Jill McMahon; Andrew P McMahon
Noggin antagonism of BMP4 signaling controls development of the axial skeleton in the mouse.
Developmental biology 2005;286(1):149-57.
2005: Forugh Vaziri Sani; Kristina Hallberg; Brian D Harfe; Andrew P McMahon; Anders Linde; Amel Gritli-Linde
Fate-mapping of the epithelial seam during palatal fusion rules out epithelial-mesenchymal transformation.
Developmental biology 2005;285(2):490-5.
2005: Thomas J. Carroll; Joo-Seop Park; Shigemi Hayashi; Arindam Majumdar; Andrew P McMahon
Wnt9b plays a central role in the regulation of mesenchymal to epithelial transitions underlying organogenesis of the mammalian urogenital system.
Developmental cell 2005;9(2):283-92.
2005: junhao mao; Jeffery R Barrow; Jill McMahon; Joe Vaughan; Andrew P McMahon
An ES cell system for rapid, spatial and temporal analysis of gene function in vitro and in vivo.
Nucleic acids research 2005;33(18):e155.
2005: Juhee Jeong; Andrew P McMahon
Growth and pattern of the mammalian neural tube are governed by partially overlapping feedback activities of the hedgehog antagonists patched 1 and Hhip1.
Development (Cambridge, England) 2005;132(1):143-54.
2004: Paul A Gray; Hui Fu; Ping Luo; Qing Zhao; Jing Yu; Annette Ferrari; Toyoaki Tenzen; Dong-In Yuk; Eric F Tsung; Zhaohui Cai; John A Alberta; Le-Ping Cheng; Yang Liu; Jan M Stenman; Michael T Valerius; Nathan Billings; Haesun A Kim; Michael E Greenberg; Andrew P McMahon; David H Rowitch; Charles D Stiles; Qiufu Ma
Mouse brain organization revealed through direct genome-scale TF expression analysis.
Science (New York, N.Y.) 2004;306(5705):2255-7.
2004: Jing Yu; Andrew P McMahon; Michael T Valerius
Recent genetic studies of mouse kidney development.
Current opinion in genetics & development 2004;14(5):550-7.
2004: Marc Fuccillo; Murielle Rallu; Andrew P McMahon; Gord Fishell
Temporal requirement for hedgehog signaling in ventral telencephalic patterning.
Development (Cambridge, England) 2004;131(20):5031-40.
2004: Steven A Vokes; Andrew P McMahon
Hedgehog signaling: iguana debuts as a nuclear gatekeeper.
Current biology : CB 2004;14(16):R668-70.
2004: Brian D Harfe; Paul J Scherz; Sahar Nissim; Hua Tian; Andrew P McMahon; Clifford J Tabin
Evidence for an expansion-based temporal Shh gradient in specifying vertebrate digit identities.
Cell 2004;118(4):517-28.
2004: Hua Tian; Toyoaki Tenzen; Andrew P McMahon
Dose dependency of Disp1 and genetic interaction between Disp1 and other hedgehog signaling components in the mouse.
Development (Cambridge, England) 2004;131(16):4021-33.
2004: Paul J Scherz; Brian D Harfe; Andrew P McMahon; Clifford J Tabin
The limb bud Shh-Fgf feedback loop is terminated by expansion of former ZPA cells.
Science (New York, N.Y.) 2004;305(5682):396-9.
2004: Paula M Lewis; Amel Gritli-Linde; Richard Smeyne; Andreas Kottmann; Andrew P McMahon
Sonic hedgehog signaling is required for expansion of granule neuron precursors and patterning of the mouse cerebellum.
Developmental biology 2004;270(2):393-410.
2004: Ritva Rice; Bradley Spencer-Dene; Elaine C Connor; Amel Gritli-Linde; Andrew P McMahon; Clive Dickson; Irma Thesleff; David P C Rice
Disruption of Fgf10/Fgfr2b-coordinated epithelial-mesenchymal interactions causes cleft palate.
The Journal of clinical investigation 2004;113(12):1692-700.
2004: Juhee Jeong; junhao mao; Toyoaki Tenzen; Andreas Kottmann; Andrew P McMahon
Hedgehog signaling in the neural crest cells regulates the patterning and growth of facial primordia.
Genes & development 2004;18(8):937-51.
2004: Fanxin Long; Ung-il Chung; Shinsuke Ohba; Jill McMahon; Henry M Kronenberg; Andrew P McMahon
Ihh signaling is directly required for the osteoblast lineage in the endochondral skeleton.
Development (Cambridge, England) 2004;131(6):1309-18.
2003: Shigemi Hayashi; Toyoaki Tenzen; Andrew P McMahon
Maternal inheritance of Cre activity in a Sox2Cre deleter strain.
Genesis (New York, N.Y. : 2000) 2003;37(2):51-3.
2003: Robert Machold; Shigemi Hayashi; Michael Rutlin; Mandar Deepak Muzumdar; Susana Nery; Joshua G Corbin; Amel Gritli-Linde; Tammy Dellovade; Jeffery A Porter; Lee L Rubin; Henryk Dudek; Andrew P McMahon; Gord Fishell
Sonic hedgehog is required for progenitor cell maintenance in telencephalic stem cell niches.
Neuron 2003;39(6):937-50.
2003: Arindam Majumdar; Seppo Vainio; Andreas Kispert; Jill McMahon; Andrew P McMahon
Wnt11 and Ret/Gdnf pathways cooperate in regulating ureteric branching during metanephric kidney development.
Development (Cambridge, England) 2003;130(14):3175-85.
2003: Keith L Ligon; Yann Echelard; Stavroula Assimacopoulos; Paul S Danielian; Sovann Kaing; Elizabeth A Grove; Andrew P McMahon; David H Rowitch
Loss of Emx2 function leads to ectopic expression of Wnt1 in the developing telencephalon and cortical dysplasia.
Development (Cambridge, England) 2003;130(10):2275-87.
2003: Jeffery R Barrow; Kirk R Thomas; Oreda Boussadia-Zahui; Robert Moore; Rolf Kemler; Mario R Capecchi; Andrew P McMahon
Ectodermal Wnt3/beta-catenin signaling is required for the establishment and maintenance of the apical ectodermal ridge.
Genes & development 2003;17(3):394-409.
2003: Andrew P McMahon; Philip Ingham; Clifford J Tabin
Developmental roles and clinical significance of hedgehog signaling.
Current topics in developmental biology 2003;53():1-114.
2002: Shigemi Hayashi; Paula Lewis; Larysa Pevny; Andrew P McMahon
Efficient gene modulation in mouse epiblast using a Sox2Cre transgenic mouse strain.
Mechanisms of development 2002;119 Suppl 1():S97-S101.
2002: Amel Gritli-Linde; Marianna Bei; Richard Maas; Xiaoyan Zhang; Anders Linde; Andrew P McMahon
Shh signaling within the dental epithelium is necessary for cell proliferation, growth and polarization.
Development (Cambridge, England) 2002;129(23):5323-37.
2002: Mark Wijgerde; Jill A McMahon; Michael Rule; Andrew P McMahon
A direct requirement for Hedgehog signaling for normal specification of all ventral progenitor domains in the presumptive mammalian spinal cord.
Genes & development 2002;16(22):2849-64.
2002: Shigemi Hayashi; Paula Lewis; Larysa Pevny; Andrew P McMahon
Efficient gene modulation in mouse epiblast using a Sox2Cre transgenic mouse strain.
Gene expression patterns : GEP 2002;2(1-2):93-7.
2002: Jing Yu; Thomas J. Carroll; Andrew P McMahon
Sonic hedgehog regulates proliferation and differentiation of mesenchymal cells in the mouse metanephric kidney.
Development (Cambridge, England) 2002;129(22):5301-12.
2002: Murielle Rallu; Robert Machold; Nicholas Gaiano; Joshua G Corbin; Andrew P McMahon; Gord Fishell
Dorsoventral patterning is established in the telencephalon of mutants lacking both Gli3 and Hedgehog signaling.
Development (Cambridge, England) 2002;129(21):4963-74.
2002: Makoto Ishibashi; Andrew P McMahon
A sonic hedgehog-dependent signaling relay regulates growth of diencephalic and mesencephalic primordia in the early mouse embryo.
Development (Cambridge, England) 2002;129(20):4807-19.
2002: Juhee Jeong; Andrew P McMahon
Cholesterol modification of Hedgehog family proteins.
The Journal of clinical investigation 2002;110(5):591-6.
2002: Sean G Megason; Andrew P McMahon
A mitogen gradient of dorsal midline Wnts organizes growth in the CNS.
Development (Cambridge, England) 2002;129(9):2087-98.
2002: Shigemi Hayashi; Andrew P McMahon
Efficient recombination in diverse tissues by a tamoxifen-inducible form of Cre: a tool for temporally regulated gene activation/inactivation in the mouse.
Developmental biology 2002;244(2):305-18.
2002: Thomas Mulroy; Jill A McMahon; Steven J Burakoff; Andrew P McMahon; Jyoti Misra Sen
Wnt-1 and Wnt-4 regulate thymic cellularity.
European journal of immunology 2002;32(4):967-71.
2002: Tiffany A Heanue; Richard J Davis; David H Rowitch; Andreas Kispert; Andrew P McMahon; Graeme Mardon; Clifford J Tabin
Dach1, a vertebrate homologue of Drosophila dachshund, is expressed in the developing eye and ear of both chick and mouse and is regulated independently of Pax and Eya genes.
Mechanisms of development 2002;111(1-2):75-87.
2001: Amel Gritli-Linde; P Lewis; Andrew P McMahon; Anders Linde
The whereabouts of a morphogen: direct evidence for short- and graded long-range activity of hedgehog signaling peptides.
Developmental biology 2001;236(2):364-86.
2001: Xiaoyan Zhang; Miguel Ramalho-Santos; Andrew P McMahon
Smoothened mutants reveal redundant roles for Shh and Ihh signaling including regulation of L/R symmetry by the mouse node.
Cell 2001;106(2):781-92.
2001: Xiaoyan Zhang; Miguel Ramalho-Santos; Andrew P McMahon
Smoothened mutants reveal redundant roles for Shh and Ihh signaling including regulation of L/R asymmetry by the mouse node.
Cell 2001;105(6):781-92.
2001: Paula M Lewis; M P Dunn; Jill A McMahon; M Logan; J F Martin; B St-Jacques; Andrew P McMahon
Cholesterol modification of sonic hedgehog is required for long-range signaling activity and effective modulation of signaling by Ptc1.
Cell 2001;105(5):599-612.
2001: M Treier; SM O'Connell; Anatoli Gleiberman; J Price; DP Szeto; R Burgess; P T Chuang; Andrew P McMahon; Michael G Rosenfeld
Hedgehog signaling is required for pituitary gland development.
Development (Cambridge, England) 2001;128(3):377-86.
2000: Thomas J. Carroll; Andrew P McMahon
Secreted molecules in metanephric induction.
Journal of the American Society of Nephrology : JASN 2000;11 Suppl 16():S116-9.
2000: Matthias Hebrok; S K Kim; B St Jacques; Andrew P McMahon; Douglas A Melton
Regulation of pancreas development by hedgehog signaling.
Development (Cambridge, England) 2000;127(22):4905-13.
2000: H R Dassule; Paula Lewis; Marianna Bei; R Maas; Andrew P McMahon
Sonic hedgehog regulates growth and morphogenesis of the tooth.
Development (Cambridge, England) 2000;127(22):4775-85.
2000: Andrew P McMahon
Neural patterning: the role of Nkx genes in the ventral spinal cord.
Genes & development 2000;14(18):2261-4.
2000: Miguel Ramalho-Santos; Douglas A Melton; Andrew P McMahon
Hedgehog signals regulate multiple aspects of gastrointestinal development.
Development (Cambridge, England) 2000;127(12):2763-72.
2000: Daniel Bachiller; John Klingensmith; C Kemp; Jose Belo; Ryan M Anderson; S R May; Jill A McMahon; Andrew P McMahon; Richard M Harland; Janet Rossant; Edward M De Robertis
The organizer factors Chordin and Noggin are required for mouse forebrain development.
Nature 2000;403(6770):658-61.
2000: Q Richard Lu; Dong-In Yuk; John A Alberta; Z Zhu; I Pawlitzky; Jennifer A Chan; Andrew P McMahon; Charles D Stiles; David H Rowitch
Sonic hedgehog--regulated oligodendrocyte lineage genes encoding bHLH proteins in the mammalian central nervous system.
Neuron 2000;25(2):317-29.
2000: Andrew P McMahon
More surprises in the Hedgehog signaling pathway.
Cell 2000;100(2):185-8.
1999: David H Rowitch; Andreas Kispert; Andrew P McMahon
Pax-2 regulatory sequences that direct transgene expression in the developing neural plate and external granule cell layer of the cerebellum.
Brain research. Developmental brain research 1999;117(1):99-108.
1999: David H Rowitch; B S-Jacques; SM Lee; Jonathan D Flax; Evan Y Snyder; Andrew P McMahon
Sonic hedgehog regulates proliferation and inhibits differentiation of CNS precursor cells.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1999;19(20):8954-65.
1999: Vladimir A Botchkarev; Natalia V Botchkareva; W Roth; M Nakamura; L H Chen; W Herzog; Gerd Lindner; Jill A McMahon; C Peters; R Lauster; Andrew P McMahon; Ralf Paus
Noggin is a mesenchymally derived stimulator of hair-follicle induction.
Nature cell biology 1999;1(3):158-64.
1999: David H Rowitch; Paul S Danielian; Andrew P McMahon; Natasa Zec
Cystic malformation of the posterior cerebellar vermis in transgenic mice that ectopically express Engrailed-1, a homeodomain transcription factor.
Teratology 1999;60(1):22-8.
1999: Norbert Perrimon; Andrew P McMahon
Negative feedback mechanisms and their roles during pattern formation.
Cell 1999;97(1):13-6.
1999: T P Yamaguchi; Allan Bradley; Andrew P McMahon; S Jones
A Wnt5a pathway underlies outgrowth of multiple structures in the vertebrate embryo.
Development (Cambridge, England) 1999;126(6):1211-23.
1999: P T Chuang; Andrew P McMahon
Vertebrate Hedgehog signalling modulated by induction of a Hedgehog-binding protein.
Nature 1999;397(6720):617-21.
1999: Seppo Vainio; Minna Heikkilä; Andreas Kispert; N Chin; Andrew P McMahon
Female development in mammals is regulated by Wnt-4 signalling.
Nature 1999;397(6718):405-9.
1998: Paul S Danielian; D Muccino; David H Rowitch; S K Michael; Andrew P McMahon
Modification of gene activity in mouse embryos in utero by a tamoxifen-inducible form of Cre recombinase.
Current biology : CB 1998;8(24):1323-6.
1998: Andreas Kispert; Seppo Vainio; Andrew P McMahon
Wnt-4 is a mesenchymal signal for epithelial transformation of metanephric mesenchyme in the developing kidney.
Development (Cambridge, England) 1998;125(21):4225-34.
1998: B A Parr; Andrew P McMahon
Sexually dimorphic development of the mammalian reproductive tract requires Wnt-7a.
Nature 1998;395(6703):707-10.
1998: B A Parr; E J Avery; J A Cygan; Andrew P McMahon
The classical mouse mutant postaxial hemimelia results from a mutation in the Wnt 7a gene.
Developmental biology 1998;202(2):228-34.
1998: C V Pepicelli; Paula M Lewis; Andrew P McMahon
Sonic hedgehog regulates branching morphogenesis in the mammalian lung.
Current biology : CB 1998;8(19):1083-6.
1998: B St-Jacques; H R Dassule; I Karavanova; Vladimir A Botchkarev; Jie Li; P S Danielian; Jill A McMahon; Paula M Lewis; Ralf Paus; Andrew P McMahon
Sonic hedgehog signaling is essential for hair development.
Current biology : CB 1998;8(19):1058-68.
1998: Y Yang; P Guillot; Yvonne Boyd; Mary F Lyon; Andrew P McMahon
Evidence that preaxial polydactyly in the Doublefoot mutant is due to ectopic Indian Hedgehog signaling.
Development (Cambridge, England) 1998;125(16):3123-32.
1998: David H Rowitch; Yann Echelard; Paul S Danielian; K Gellner; Sydney Brenner; Andrew P McMahon
Identification of an evolutionarily conserved 110 base-pair cis-acting regulatory sequence that governs Wnt-1 expression in the murine neural plate.
Development (Cambridge, England) 1998;125(14):2735-46.
1998: M Treier; Anatoli Gleiberman; SM O'Connell; DP Szeto; J A McMahon; Andrew P McMahon; Michael G Rosenfeld
Multistep signaling requirements for pituitary organogenesis in vivo.
Genes & development 1998;12(11):1691-704.
1998: Lisa J Brunet; Jill A McMahon; Andrew P McMahon; Richard M Harland
Noggin, cartilage morphogenesis, and joint formation in the mammalian skeleton.
Science (New York, N.Y.) 1998;280(5368):1455-7.
1998: Jill A McMahon; S Takada; L B Zimmerman; C M Fan; Richard M Harland; Andrew P McMahon
Noggin-mediated antagonism of BMP signaling is required for growth and patterning of the neural tube and somite.
Genes & development 1998;12(10):1438-52.
1998: M Hammerschmidt; Andrew P McMahon
The effect of pertussis toxin on zebrafish development: a possible role for inhibitory G-proteins in hedgehog signaling.
Developmental biology 1998;194(2):166-71.
1997: Paul S Danielian; Yann Echelard; G Vassileva; Andrew P McMahon
A 5.5-kb enhancer is both necessary and sufficient for regulation of Wnt-1 transcription in vivo.
Developmental biology 1997;192(2):300-9.
1997: J A Cygan; R L Johnson; Andrew P McMahon
Novel regulatory interactions revealed by studies of murine limb pattern in Wnt-7a and En-1 mutants.
Development (Cambridge, England) 1997;124(24):5021-32.
1997: SM Lee; Paul S Danielian; B Fritzsch; Andrew P McMahon
Evidence that FGF8 signalling from the midbrain-hindbrain junction regulates growth and polarity in the developing midbrain.
Development (Cambridge, England) 1997;124(5):959-69.
1997: David H Rowitch; Paul S Danielian; SM Lee; Yann Echelard; Andrew P McMahon
Cell interactions in patterning the mammalian midbrain.
Cold Spring Harbor symposia on quantitative biology 1997;62():535-44.
1996: Andreas Kispert; Seppo Vainio; L Shen; David H Rowitch; Andrew P McMahon
Proteoglycans are required for maintenance of Wnt-11 expression in the ureter tips.
Development (Cambridge, England) 1996;122(11):3627-37.
1996: G N Serbedzija; M Dickinson; Andrew P McMahon
Cell death in the CNS of the Wnt-1 mutant mouse.
Journal of neurobiology 1996;31(3):275-82.
1996: M Hammerschmidt; G N Serbedzija; Andrew P McMahon
Genetic analysis of dorsoventral pattern formation in the zebrafish: requirement of a BMP-like ventralizing activity and its dorsal repressor.
Genes & development 1996;10(19):2452-61.
1996: Paul S Danielian; Andrew P McMahon
Engrailed-1 as a target of the Wnt-1 signalling pathway in vertebrate midbrain development.
Nature 1996;383(6598):332-4.
1996: D J Epstein; E Marti; M P Scott; Andrew P McMahon
Antagonizing cAMP-dependent protein kinase A in the dorsal CNS activates a conserved Sonic hedgehog signaling pathway.
Development (Cambridge, England) 1996;122(9):2885-94.
1996: B St-Jacques; Andrew P McMahon
Early mouse development: lessons from gene targeting.
Current opinion in genetics & development 1996;6(4):439-44.
1996: M Hammerschmidt; M J Bitgood; Andrew P McMahon
Protein kinase A is a common negative regulator of Hedgehog signaling in the vertebrate embryo.
Genes & development 1996;10(6):647-58.
1996: M J Bitgood; L Shen; Andrew P McMahon
Sertoli cell signaling by Desert hedgehog regulates the male germline.
Current biology : CB 1996;6(3):298-304.
1996: D A Bumcrot; Andrew P McMahon
Sonic hedgehog: making the gradient.
Chemistry & biology 1996;3(1):13-6.
1995: Andrea Munsterberg; J Kitajewski; D A Bumcrot; Andrew P McMahon; Andrew B Lassar
Combinatorial signaling by Sonic hedgehog and Wnt family members induces myogenic bHLH gene expression in the somite.
Genes & development 1995;9(23):2911-22.
1995: M J Bitgood; Andrew P McMahon
Hedgehog and Bmp genes are coexpressed at many diverse sites of cell-cell interaction in the mouse embryo.
Developmental biology 1995;172(1):126-38.
1995: L W Burrus; Andrew P McMahon
Biochemical analysis of murine Wnt proteins reveals both shared and distinct properties.
Experimental cell research 1995;220(2):363-73.
1995: Nancy Iler; David H Rowitch; Yann Echelard; Andrew P McMahon; Cory Abate-Shen
A single homeodomain binding site restricts spatial expression of Wnt-1 in the developing brain.
Mechanisms of development 1995;53(1):87-96.
1995: E Martí; R Takada; D A Bumcrot; H Sasaki; Andrew P McMahon
Distribution of Sonic hedgehog peptides in the developing chick and mouse embryo.
Development (Cambridge, England) 1995;121(8):2537-47.
1995: M E Dickinson; M A Selleck; Andrew P McMahon; Marianne Bronner-Fraser
Dorsalization of the neural tube by the non-neural ectoderm.
Development (Cambridge, England) 1995;121(7):2099-106.
1995: David H Rowitch; Andrew P McMahon
Pax-2 expression in the murine neural plate precedes and encompasses the expression domains of Wnt-1 and En-1.
Mechanisms of development 1995;52(1):3-8.
1995: D A Bumcrot; Andrew P McMahon
Somite differentiation. Sonic signals somites.
Current biology : CB 1995;5(6):612-4.
1995: E Martí; D A Bumcrot; R Takada; Andrew P McMahon
Requirement of 19K form of Sonic hedgehog for induction of distinct ventral cell types in CNS explants.
Nature 1995;375(6529):322-5.
1995: D A Bumcrot; R Takada; Andrew P McMahon
Proteolytic processing yields two secreted forms of sonic hedgehog.
Molecular and cellular biology 1995;15(4):2294-303.
1995: B A Parr; Andrew P McMahon
Dorsalizing signal Wnt-7a required for normal polarity of D-V and A-P axes of mouse limb.
Nature 1995;374(6520):350-3.
1994: K Stark; Seppo Vainio; G Vassileva; Andrew P McMahon
Epithelial transformation of metanephric mesenchyme in the developing kidney regulated by Wnt-4.
Nature 1994;372(6507):679-83.
1994: Andrew P McMahon
Mouse development. Winged-helix in axial patterning.
Current biology : CB 1994;4(10):903-6.
1994: B A Parr; Andrew P McMahon
Wnt genes and vertebrate development.
Current opinion in genetics & development 1994;4(4):523-8.
1994: Yann Echelard; G Vassileva; Andrew P McMahon
Cis-acting regulatory sequences governing Wnt-1 expression in the developing mouse CNS.
Development (Cambridge, England) 1994;120(8):2213-24.
1994: M E Dickinson; R Krumlauf; Andrew P McMahon
Evidence for a mitogenic effect of Wnt-1 in the developing mammalian central nervous system.
Development (Cambridge, England) 1994;120(6):1453-71.
1994: Z Shang; Y W Ebright; Nancy Iler; P S Pendergrast; Yann Echelard; Andrew P McMahon; Richard H. Ebright; C Abate
DNA affinity cleaving analysis of homeodomain-DNA interaction: identification of homeodomain consensus sites in genomic DNA.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(1):118-22.
1994: S Takada; K L Stark; M J Shea; G Vassileva; J A McMahon; Andrew P McMahon
Wnt-3a regulates somite and tailbud formation in the mouse embryo.
Genes & development 1994;8(2):174-89.
1993: Y Echelard; D J Epstein; B St-Jacques; L Shen; J Mohler; Jill A McMahon; Andrew P McMahon
Sonic hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity.
Cell 1993;75(7):1417-30.
1993: B A Parr; M J Shea; G Vassileva; Andrew P McMahon
Mouse Wnt genes exhibit discrete domains of expression in the early embryonic CNS and limb buds.
Development (Cambridge, England) 1993;119(1):247-61.
1992: F F Del Amo; D E Smith; P J Swiatek; M Gendron-Maguire; Ralph J Greenspan; Andrew P McMahon; Thomas Gridley
Expression pattern of Motch, a mouse homolog of Drosophila Notch, suggests an important role in early postimplantation mouse development.
Development (Cambridge, England) 1992;115(3):737-44.
1992: Andrew P McMahon; Alexandra L Joyner; A Bradley; J A McMahon
The midbrain-hindbrain phenotype of Wnt-1-/Wnt-1- mice results from stepwise deletion of engrailed-expressing cells by 9.5 days postcoitum.
Cell 1992;69(4):581-95.
1992: B J Gavin; Andrew P McMahon
Differential regulation of the Wnt gene family during pregnancy and lactation suggests a role in postnatal development of the mammary gland.
Molecular and cellular biology 1992;12(5):2418-23.
1992: Andrew P McMahon; B J Gavin; B Parr; A Bradley; J A McMahon
The Wnt family of cell signalling molecules in postimplantation development of the mouse.
Ciba Foundation symposium 1992;165():199-212; discussion 212-8.
1991: K L Stark; J A McMahon; Andrew P McMahon
FGFR-4, a new member of the fibroblast growth factor receptor family, expressed in the definitive endoderm and skeletal muscle lineages of the mouse.
Development (Cambridge, England) 1991;113(2):641-51.
1990: B J Gavin; J A McMahon; Andrew P McMahon
Expression of multiple novel Wnt-1/int-1-related genes during fetal and adult mouse development.
Genes & development 1990;4(12B):2319-32.
1990: Andrew P McMahon; A Bradley
The Wnt-1 (int-1) proto-oncogene is required for development of a large region of the mouse brain.
Cell 1990;62(6):1073-85.
1989: J A McMahon; Andrew P McMahon
Nucleotide sequence, chromosomal localization and developmental expression of the mouse int-1-related gene.
Development (Cambridge, England) 1989;107(3):643-50.
1989: Andrew P McMahon; Randall T Moon
Ectopic expression of the proto-oncogene int-1 in Xenopus embryos leads to duplication of the embryonic axis.
Cell 1989;58(6):1075-84.
1989: Andrew P McMahon; Randall T Moon
int-1--a proto-oncogene involved in cell signalling.
Development (Cambridge, England) 1989;107 Suppl():161-7.