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Harvey McMahon

Research Profile

Physiology

Endocytosis

Concepts & Ideas

Chemicals & Drugs

Anatomy

Co-author Network

Publications

TOP 3
Michael Meinecke; Rohit Mittal; Emmanuel Boucrot; Gamze Camdere; Wai-Ching Hon; Harvey T McMahon
Cooperative recruitment of dynamin and BIN/amphiphysin/Rvs (BAR) domain-containing proteins leads to GTP-dependent membrane scission.
Katia Cortese; Mark T Howes; Richard Lundmark; Harvey T McMahon; Robert G Parton; Annalisa Petrelli; Paola Bagnato; Maria Bono; Erica Tagliatti; Carlo Tacchetti
The HSP90 inhibitor geldanamycin perturbs endosomal structure and drives recycling ErbB2 and transferrin to modified MVBs/lysosomal compartments.
Chun-Liang Lai; Ralf Langen; Edward Lyman; Harvey T McMahon; Brian J Peter; Jennifer L Gallop; Christine C Jao; Gregory A Voth
Membrane binding and self-association of the epsin N-terminal homology domain.

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All Publications

2013: Michael Meinecke; Rohit Mittal; Emmanuel Boucrot; Gamze Camdere; Wai-Ching Hon; Harvey T McMahon
Cooperative recruitment of dynamin and BIN/amphiphysin/Rvs (BAR) domain-containing proteins leads to GTP-dependent membrane scission.
The Journal of biological chemistry 2013;288(9):6651-61.
2013: Katia Cortese; Mark T Howes; Richard Lundmark; Harvey T McMahon; Robert G Parton; Annalisa Petrelli; Paola Bagnato; Maria Bono; Erica Tagliatti; Carlo Tacchetti
The HSP90 inhibitor geldanamycin perturbs endosomal structure and drives recycling ErbB2 and transferrin to modified MVBs/lysosomal compartments.
Molecular biology of the cell 2013;24(2):129-44.
2012: Chun-Liang Lai; Ralf Langen; Edward Lyman; Harvey T McMahon; Brian J Peter; Jennifer L Gallop; Christine C Jao; Gregory A Voth
Membrane binding and self-association of the epsin N-terminal homology domain.
Journal of molecular biology 2012;423(5):800-17.
2012: Violeta Chitu; Renee Harris; William M Henne; Halley Ketchum; Harvey T McMahon; Viorel Nacu; Mary C Nakamura; Sayan Nandi; Julia F Charles; E Richard Stanley
PSTPIP2 deficiency in mice causes osteopenia and increased differentiation of multipotent myeloid precursors into osteoclasts.
Blood 2012;120(15):3126-35.
2012: Björn Morén; Robert G Parton; Nicole L Schieber; Claudio Shah; Oliver Daumke; Mark T Howes; Harvey T McMahon; Richard Lundmark
EHD2 regulates caveolar dynamics via ATP-driven targeting and oligomerization.
Molecular biology of the cell 2012;23(7):1316-29.
2012: Emmanuel Boucrot; Emma Evergren; Nicole Liska; Harvey T McMahon; Adi Pick; Gamze Çamdere; Michael M Kozlov
Membrane fission is promoted by insertion of amphipathic helices and is restricted by crescent BAR domains.
Cell 2012;149(1):124-36.
2012: María José Sánchez-Barrena; Yvonne Vallis; Dmitry B Veprintsev; Menna R Clatworthy; Gary Doherty; Philip R Evans; Harvey T McMahon
Bin2 is a membrane sculpting N-BAR protein that influences leucocyte podosomes, motility and phagocytosis.
PloS one 2012;7(12):e52401.
2011: Jean-Philippe Richard; Tamas Balla; William Mike Henne; Michael M Kozlov; Ralf Langen; Eugenia Leikina; Harvey T McMahon; Margarita Popova; Leonid V Chernomordik
Intracellular curvature-generating proteins in cell-to-cell fusion.
The Biochemical journal 2011;440(2):185-93.
2011: Gary Doherty; Mark T Howes; Harvey T McMahon; Björn Morén; Robert G Parton; Monika K Åhlund; Richard Lundmark
The endocytic protein GRAF1 is directed to cell-matrix adhesion sites and regulates cell spreading.
Molecular biology of the cell 2011;22(22):4380-9.
2011: Harvey T McMahon; Emmanuel Boucrot
Molecular mechanism and physiological functions of clathrin-mediated endocytosis.
Nature reviews. Molecular cell biology 2011;12(8):517-33.
2011: Artur Llobet; Yvonne Vallis; Jemima Burden; Gamze Camdere; Priya Chandra; Jennifer L Gallop; Colin R Hopkins; Leon Lagnado; Harvey T McMahon
Endophilin drives the fast mode of vesicle retrieval in a ribbon synapse.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2011;31(23):8512-9.
2011: Emmanuel Boucrot; Harvey T McMahon
[Nucleation of clathrin-coated pits - « membrane sculptors » at work].
Médecine sciences : M/S 2011;27(2):122-5.
2011: Sascha Martens; Harvey T McMahon
C2 domains and membrane fusion.
Current topics in membranes 2011;68():141-59.
2010: Michael M Kozlov; Harvey T McMahon; Leonid V Chernomordik
Protein-driven membrane stresses in fusion and fission.
Trends in biochemical sciences 2010;35(12):699-706.
2010: Ji-Young Youn; Helena Friesen; Takuma Kishimoto; William M Henne; Christoph F Kurat; Wei Ye; Derek F Ceccarelli; Frank Sicheri; Sepp D Kohlwein; Harvey T McMahon; Brenda J Andrews
Dissecting BAR domain function in the yeast Amphiphysins Rvs161 and Rvs167 during endocytosis.
Molecular biology of the cell 2010;21(17):3054-69.
2010: Rohit Mittal; Sew-Yeu Peak Chew; Robert S Sade; Yvonne Vallis; Harvey T McMahon
The acetyltransferase activity of the bacterial toxin YopJ of Yersinia is activated by eukaryotic host cell inositol hexakisphosphate.
The Journal of biological chemistry 2010;285(26):19927-34.
2010: Christine C Jao; Balachandra G Hegde; Jennifer L Gallop; Prabhavati B Hegde; Harvey T McMahon; Ian S Haworth; Ralf Langen
Roles of amphipathic helices and the bin/amphiphysin/rvs (BAR) domain of endophilin in membrane curvature generation.
The Journal of biological chemistry 2010;285(26):20164-70.
2010: William Mike Henne; Emmanuel Boucrot; Michael Meinecke; Emma Evergren; Yvonne Vallis; Rohit Mittal; Harvey T McMahon
FCHo proteins are nucleators of clathrin-mediated endocytosis.
Science (New York, N.Y.) 2010;328(5983):1281-4.
2010: Felix Campelo; Gur Fabrikant; Harvey T McMahon; Michael M Kozlov
Modeling membrane shaping by proteins: focus on EHD2 and N-BAR domains.
FEBS letters 2010;584(9):1830-9.
2010: Sander Groffen; Sascha Martens; Rocío Díez Arazola; L Niels Cornelisse; Natalia Lozovaya; Arthur P H de Jong; Natalia A Goriounova; Ron L P Habets; Yoshimi Takai; J Gerard Borst; Nils Brose; Harvey T McMahon; Matthijs Verhage
Doc2b is a high-affinity Ca2+ sensor for spontaneous neurotransmitter release.
Science (New York, N.Y.) 2010;327(5973):1614-8.
2010: Harvey T McMahon; Michael M Kozlov; Sascha Martens
Membrane curvature in synaptic vesicle fusion and beyond.
Cell 2010;140(5):601-5.
2009: Gary J Doherty; Harvey T McMahon
Mechanisms of endocytosis.
Annual review of biochemistry 2009;78():857-902.
2009: Alexander Eberth; Richard Lundmark; Lothar Gremer; Radovan Dvorsky; Katja T Koessmeier; Harvey T McMahon; Mohammad Reza Ahmadian
A BAR domain-mediated autoinhibitory mechanism for RhoGAPs of the GRAF family.
The Biochemical journal 2009;417(1):371-7.
2008: Kara L Lynch; Roy R L Gerona; Dana M Kielar; Sascha Martens; Harvey T McMahon; Thomas F J Martin
Synaptotagmin-1 utilizes membrane bending and SNARE binding to drive fusion pore expansion.
Molecular biology of the cell 2008;19(12):5093-103.
2008: Richard Lundmark; Gary J Doherty; Mark T Howes; Katia Cortese; Yvonne Vallis; Robert Parton; Harvey T McMahon
The GTPase-activating protein GRAF1 regulates the CLIC/GEEC endocytic pathway.
Current biology : CB 2008;18(22):1802-8.
2008: Richard Lundmark; Gary Doherty; Yvonne Vallis; Brian J Peter; Harvey T McMahon
Arf family GTP loading is activated by, and generates, positive membrane curvature.
The Biochemical journal 2008;414(2):189-94.
2008: Felix Campelo; Harvey T McMahon; Michael M Kozlov
The hydrophobic insertion mechanism of membrane curvature generation by proteins.
Biophysical journal 2008;95(5):2325-39.
2008: Kenneth L Madsen; Jacob Eriksen; Laura Milan-Lobo; Daniel S Han; Masha Y Niv; Ina Ammendrup-Johnsen; Ulla Henriksen; Vikram K Bhatia; Dimitrios Stamou; Harald H Sitte; Harvey T McMahon; HAREL WEINSTEIN; Ulrik Gether
Membrane localization is critical for activation of the PICK1 BAR domain.
Traffic (Copenhagen, Denmark) 2008;9(8):1327-43.
2008: Sascha Martens; Harvey T McMahon
Mechanisms of membrane fusion: disparate players and common principles.
Nature reviews. Molecular cell biology 2008;9(7):543-56.
2008: Lene E Olesen; Marijn G J Ford; Eva M Schmid; Yvonne Vallis; M Madan Babu; Peter H Li; Ian Mills; Harvey T McMahon; Gerrit J K Praefcke
Solitary and repetitive binding motifs for the AP2 complex alpha-appendage in amphiphysin and other accessory proteins.
The Journal of biological chemistry 2008;283(8):5099-109.
2008: Gary Doherty; Harvey T McMahon
Mediation, modulation, and consequences of membrane-cytoskeleton interactions.
Annual review of biophysics 2008;37():65-95.
2007: Eva M Schmid; Harvey T McMahon
Integrating molecular and network biology to decode endocytosis.
Nature 2007;448(7156):883-8.
2007: Anne Burtey; Eva M Schmid; Marijn G J Ford; Joshua Z Rappoport; Mark SCOTT; Stefano Marullo; Sanford M Simon; Harvey T McMahon; Alexandre Benmerah
The conserved isoleucine-valine-phenylalanine motif couples activation state and endocytic functions of beta-arrestins.
Traffic (Copenhagen, Denmark) 2007;8(7):914-31.
2007: William Mike Henne; Helen M Kent; Marijn G J Ford; Balachandra G Hegde; Oliver Daumke; P Jonathan G Butler; Rohit Mittal; Ralf Langen; Philip R Evans; Harvey T McMahon
Structure and analysis of FCHo2 F-BAR domain: a dimerizing and membrane recruitment module that effects membrane curvature.
Structure (London, England : 1993) 2007;15(7):839-52.
2007: Sascha Martens; Michael M Kozlov; Harvey T McMahon
How synaptotagmin promotes membrane fusion.
Science (New York, N.Y.) 2007;316(5828):1205-8.
2006: Rohit Mittal; Sew-Yeu Peak Chew; Harvey T McMahon
Acetylation of MEK2 and I kappa B kinase (IKK) activation loop residues by YopJ inhibits signaling.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(49):18574-9.
2006: Eva M Schmid; Marijn G J Ford; Anne Burtey; Gerrit J K Praefcke; Sew-Yeu Peak Chew; Ian Mills; Alexandre Benmerah; Harvey T McMahon
Role of the AP2 beta-appendage hub in recruiting partners for clathrin-coated vesicle assembly.
PLoS biology 2006;4(9):e262.
2006: Jennifer L Gallop; Christine C Jao; Helen M Kent; P Jonathan G Butler; Philip R Evans; Ralf Langen; Harvey T McMahon
Mechanism of endophilin N-BAR domain-mediated membrane curvature.
The EMBO journal 2006;25(12):2898-910.
2005: Jennifer L Gallop; P Jonathan G Butler; Harvey T McMahon
Endophilin and CtBP/BARS are not acyl transferases in endocytosis or Golgi fission.
Nature 2005;438(7068):675-8.
2005: Harvey T McMahon; Jennifer L Gallop
Membrane curvature and mechanisms of dynamic cell membrane remodelling.
Nature 2005;438(7068):590-6.
2005: Jez G Carlton; Miriam V Bujny; Brian J Peter; Viola Oorschot; Anna Rutherford; Rebecca S Arkell; Judith Klumperman; Harvey T McMahon; Peter J Cullen
Sorting nexin-2 is associated with tubular elements of the early endosome, but is not essential for retromer-mediated endosome-to-TGN transport.
Journal of cell science 2005;118(Pt 19):4527-39.
2005: Wolf J Jockusch; Gerrit J K Praefcke; Harvey T McMahon; Leon Lagnado
Clathrin-dependent and clathrin-independent retrieval of synaptic vesicles in retinal bipolar cells.
Neuron 2005;46(6):869-78.
2005: Matthew K Higgins; Harvey T McMahon
In vitro reconstitution of discrete stages of dynamin-dependent endocytosis.
Methods in enzymology 2005;404():597-611.
2005: Jennifer L Gallop; Harvey T McMahon
BAR domains and membrane curvature: bringing your curves to the BAR.
Biochemical Society symposium 2005;(72):223-31.
2004: Gerrit J K Praefcke; Marijn G J Ford; Eva M Schmid; Lene E Olesen; Jennifer L Gallop; Sew-Yeu Peak Chew; Yvonne Vallis; M Madan Babu; Ian Mills; Harvey T McMahon
Evolving nature of the AP2 alpha-appendage hub during clathrin-coated vesicle endocytosis.
The EMBO journal 2004;23(22):4371-83.
2004: Takashi Tsuboi; Harvey T McMahon; Guy A Rutter
Mechanisms of dense core vesicle recapture following "kiss and run" ("cavicapture") exocytosis in insulin-secreting cells.
The Journal of biological chemistry 2004;279(45):47115-24.
2004: Jez G Carlton; Miriam V Bujny; Brian J Peter; Viola Oorschot; Anna Rutherford; Harry Mellor; Judith Klumperman; Harvey T McMahon; Peter J Cullen
Sorting nexin-1 mediates tubular endosome-to-TGN transport through coincidence sensing of high- curvature membranes and 3-phosphoinositides.
Current biology : CB 2004;14(20):1791-800.
2004: Harvey T McMahon; Ian Mills
COP and clathrin-coated vesicle budding: different pathways, common approaches.
Current opinion in cell biology 2004;16(4):379-91.
2004: Agnès Saint-Pol; Belén Yélamos; Mohamed Amessou; Ian Mills; Marc Dugast; Danièle Tenza; Peter Schu; Claude Antony; Harvey T McMahon; Christophe Lamaze; Ludger Johannes
Clathrin adaptor epsinR is required for retrograde sorting on early endosomal membranes.
Developmental cell 2004;6(4):525-38.
2004: Gerrit J K Praefcke; Harvey T McMahon
The dynamin superfamily: universal membrane tubulation and fission molecules?
Nature reviews. Molecular cell biology 2004;5(2):133-47.
2004: Brian J Peter; Helen M Kent; Ian Mills; Yvonne Vallis; P Jonathan G Butler; Philip R Evans; Harvey T McMahon
BAR domains as sensors of membrane curvature: the amphiphysin BAR structure.
Science (New York, N.Y.) 2004;303(5657):495-9.
2003: Robert V Stahelin; Fei Long; Brian J Peter; Diana Murray; Pietro De Camilli; Harvey T McMahon; Wonhwa Cho
Contrasting membrane interaction mechanisms of AP180 N-terminal homology (ANTH) and epsin N-terminal homology (ENTH) domains.
The Journal of biological chemistry 2003;278(31):28993-9.
2003: Ian Mills; Gerrit J K Praefcke; Yvonne Vallis; Brian J Peter; Lene E Olesen; Jennifer L Gallop; P Jonathan G Butler; Philip R Evans; Harvey T McMahon
EpsinR: an AP1/clathrin interacting protein involved in vesicle trafficking.
The Journal of cell biology 2003;160(2):213-22.
2002: Marijn G J Ford; Ian Mills; Brian J Peter; Yvonne Vallis; Gerrit J K Praefcke; Philip R Evans; Harvey T McMahon
Curvature of clathrin-coated pits driven by epsin.
Nature 2002;419(6905):361-6.
2002: Helen M Kent; Harvey T McMahon; Philip R Evans; Alexandre Benmerah; David J Owen
Gamma-adaptin appendage domain: structure and binding site for Eps15 and gamma-synergin.
Structure (London, England : 1993) 2002;10(8):1139-48.
2002: Margaret E Graham; Dermott W O'Callaghan; Harvey T McMahon; Robert D Burgoyne
Dynamin-dependent and dynamin-independent processes contribute to the regulation of single vesicle release kinetics and quantal size.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(10):7124-9.
2002: Matthew K Higgins; Harvey T McMahon
Snap-shots of clathrin-mediated endocytosis.
Trends in biochemical sciences 2002;27(5):257-63.
2001: B Marks; MH Stowell; Yvonne Vallis; Ian Mills; A Gibson; C R Hopkins; Harvey T McMahon
GTPase activity of dynamin and resulting conformation change are essential for endocytosis.
Nature 2001;410(6825):231-5.
2001: Marijn G J Ford; BM Pearse; Matthew K Higgins; Yvonne Vallis; David J Owen; A Gibson; C R Hopkins; Philip R Evans; Harvey T McMahon
Simultaneous binding of PtdIns(4,5)P2 and clathrin by AP180 in the nucleation of clathrin lattices on membranes.
Science (New York, N.Y.) 2001;291(5506):1051-5.
2000: David J Owen; Yvonne Vallis; BM Pearse; Harvey T McMahon; Philip R Evans
The structure and function of the beta 2-adaptin appendage domain.
The EMBO journal 2000;19(16):4216-27.
1999: David J Owen; Yvonne Vallis; Martin E M Noble; J B Hunter; T R Dafforn; Philip R Evans; Harvey T McMahon
A structural explanation for the binding of multiple ligands by the alpha-adaptin appendage domain.
Cell 1999;97(6):805-15.
1999: Harvey T McMahon
Endocytosis: an assembly protein for clathrin cages.
Current biology : CB 1999;9(9):R332-5.
1999: MH Stowell; B Marks; P Wigge; Harvey T McMahon
Nucleotide-dependent conformational changes in dynamin: evidence for a mechanochemical molecular spring.
Nature cell biology 1999;1(1):27-32.
1999: Yvonne Vallis; P Wigge; B Marks; Philip R Evans; Harvey T McMahon
Importance of the pleckstrin homology domain of dynamin in clathrin-mediated endocytosis.
Current biology : CB 1999;9(5):257-60.
1998: David J Owen; P Wigge; Yvonne Vallis; J D Moore; Philip R Evans; Harvey T McMahon
Crystal structure of the amphiphysin-2 SH3 domain and its role in the prevention of dynamin ring formation.
The EMBO journal 1998;17(18):5273-85.
1998: P Wigge; Harvey T McMahon
The amphiphysin family of proteins and their role in endocytosis at the synapse.
Trends in neurosciences 1998;21(8):339-44.
1998: B Marks; Harvey T McMahon
Calcium triggers calcineurin-dependent synaptic vesicle recycling in mammalian nerve terminals.
Current biology : CB 1998;8(13):740-9.
1997: P Wigge; K Köhler; Yvonne Vallis; CA Doyle; D Owen; Stephen P Hunt; Harvey T McMahon
Amphiphysin heterodimers: potential role in clathrin-mediated endocytosis.
Molecular biology of the cell 1997;8(10):2003-15.
1997: Harvey T McMahon; P Wigge; C Smith
Clathrin interacts specifically with amphiphysin and is displaced by dynamin.
FEBS letters 1997;413(2):319-22.
1997: P Wigge; Yvonne Vallis; Harvey T McMahon
Inhibition of receptor-mediated endocytosis by the amphiphysin SH3 domain.
Current biology : CB 1997;7(8):554-60.