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James McMahon

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HIV-1
HIV-2

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Krishna P Devkota; Curtis J Henrich; James B McMahon; Karlyne M Reilly; Jennifer Wilson; John A Beutler
Isobutylhydroxyamides from the pericarp of Nepalese Zanthoxylum armatum inhibit NF1-defective tumor cell line growth.
Tawnya C McKee; James B McMahon; Daniel Rabe; Albert W W Van Wyk; Emily L Whitson; Thushara Diyabalanage; Roberta S Gardella; Tanja Grkovic; Kirk R Gustafson; W Marston Linehan; Stephanie R Marcum; Heidi R Bokesch; Donald P Bottaro
Inhibition of hypoxia inducible factor-2 transcription: isolation of active modulators from marine sponges.
Thushara Diyabalanage; John A Beutler; Heidi R Bokesch; Curtis J Henrich; James B McMahon; Tanya T Ransom; Ranjala Ratnayake; Kirk R Gustafson
Flabelliferins A and B, sesterterpenoids from the South Pacific sponge Carteriospongia flabellifera.

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2013: Krishna P Devkota; Curtis J Henrich; James B McMahon; Karlyne M Reilly; Jennifer Wilson; John A Beutler
Isobutylhydroxyamides from the pericarp of Nepalese Zanthoxylum armatum inhibit NF1-defective tumor cell line growth.
Journal of natural products 2013;76(1):59-63.
2012: Tawnya C McKee; James B McMahon; Daniel Rabe; Albert W W Van Wyk; Emily L Whitson; Thushara Diyabalanage; Roberta S Gardella; Tanja Grkovic; Kirk R Gustafson; W Marston Linehan; Stephanie R Marcum; Heidi R Bokesch; Donald P Bottaro
Inhibition of hypoxia inducible factor-2 transcription: isolation of active modulators from marine sponges.
Journal of natural products 2012;75(9):1632-6.
2012: Thushara Diyabalanage; John A Beutler; Heidi R Bokesch; Curtis J Henrich; James B McMahon; Tanya T Ransom; Ranjala Ratnayake; Kirk R Gustafson
Flabelliferins A and B, sesterterpenoids from the South Pacific sponge Carteriospongia flabellifera.
Journal of natural products 2012;75(8):1490-4.
2012: Girma M Woldemichael; W Marston Linehan; Thomas J Turbyville; James R Vasselli; James B McMahon
Lack of a functional VHL gene product sensitizes renal cell carcinoma cells to the apoptotic effects of the protein synthesis inhibitor verrucarin A.
Neoplasia (New York, N.Y.) 2012;14(8):771-7.
2012: Emily L Whitson; Christian Griesinger; Curtis J Henrich; James B McMahon; Thomas J Sayers; Han Sun; Cheryl L Thomas; Tawnya C McKee
Synergistic TRAIL sensitizers from Barleria alluaudii and Diospyros maritima.
Journal of natural products 2012;75(3):394-9.
2012: Rhone K Akee; James B McMahon; Tanya Ransom; Ranjala Ratnayake; John A Beutler
Chlorinated englerins with selective inhibition of renal cancer cell growth.
Journal of natural products 2012;75(3):459-63.
2012: Johanna S Blees; Heidi R Bokesch; Magdalena M Bajer; Nancy H Colburn; Kirk R Gustafson; Curtis J Henrich; James B McMahon; Larissa Milke; Daniela Rübsamen; Tobias Schmid; Kathrin Schulz; Bernhard Brüne
Erioflorin stabilizes the tumor suppressor Pdcd4 by inhibiting its interaction with the E3-ligase β-TrCP1.
PloS one 2012;7(10):e46567.
2011: Li-Xing Zhao; Shu-Kun Tang; John A Beutler; Johanna S Blees; Nancy H Colburn; Yanwen Duan; Curtis J Henrich; Sheng-Xiong Huang; Cheng-Lin Jiang; James B McMahon; Scott R Rajski; Tobias Schmid; Ben Shen
Actinopolysporins A-C and tubercidin as a Pdcd4 stabilizer from the halophilic actinomycete Actinopolyspora erythraea YIM 90600.
Journal of natural products 2011;74(9):1990-5.
2011: Wendy L Popplewell; Ranjala Ratnayake; Jennifer A Wilson; James B McMahon; John A Beutler; Nancy H Colburn; Curtis J Henrich; Tawnya C McKee
Grassypeptolides F and G, cyanobacterial peptides from Lyngbya majuscula.
Journal of natural products 2011;74(8):1686-91.
2011: Thushara Diyabalanage; John A Beutler; Nancy H Colburn; Curtis J Henrich; James B McMahon; Ranjala Ratnayake; Jennifer A Wilson; Kirk R Gustafson
Nothospondin, a new AP-1 inhibitory quassinoid from the Cameroonian plant Nothospondias staudtii.
Bioorganic & medicinal chemistry letters 2011;21(15):4397-9.
2011: Emily L Whitson; Matthew D Hall; James B McMahon; Kristen M Pluchino; Tawnya C McKee
New candidaspongiolides, tedanolide analogues that selectively inhibit melanoma cell growth.
Organic letters 2011;13(13):3518-21.
2011: Patrick J Grohar; Qing-Rong Chen; Duane G Currier; Sean Davis; Laurie B Griffin; Javed Khan; Chand Khanna; James B McMahon; Arnulfo Mendoza; Girma M Woldemichael; Choh Yeung; Lee Helman
Identification of an inhibitor of the EWS-FLI1 oncogenic transcription factor by high-throughput screening.
Journal of the National Cancer Institute 2011;103(12):962-78.
2011: Tanja Grkovic; Johanna S Blees; Nancy H Colburn; Tobias Schmid; Cheryl L Thomas; Curtis J Henrich; James B McMahon; Kirk R Gustafson
Cryptocaryols A-H, α-pyrone-containing 1,3-polyols from Cryptocarya sp. implicated in stabilizing the tumor suppressor Pdcd4.
Journal of natural products 2011;74(5):1015-20.
2011: Jeong Ah Kim; Seo Young Yang; Antony Wamiru; James B McMahon; Stuart F J Le Grice; John A Beutler; Young Ho Kim
New monoterpene glycosides and phenolic compounds from Distylium racemosum and their inhibitory activity against ribonuclease H.
Bioorganic & medicinal chemistry letters 2011;21(10):2840-4.
2011: Tanja Grkovic; Emily L Whitson; Daniel C Rabe; Roberta S Gardella; Donald Bottaro; W Marston Linehan; James B McMahon; Kirk R Gustafson; Tawnya C McKee
Identification and evaluation of soft coral diterpenes as inhibitors of HIF-2α induced gene expression.
Bioorganic & medicinal chemistry letters 2011;21(7):2113-5.
2011: Krishna P Devkota; Ranjala Ratnayake; Nancy H Colburn; Jennifer A Wilson; Curtis J Henrich; James B McMahon; John A Beutler
Inhibitors of the oncogenic transcription factor AP-1 from Podocarpus latifolius.
Journal of natural products 2011;74(3):374-7.
2011: Muhammad Ali Versiani; Thushara Diyabalanage; Ranjala Ratnayake; Curtis J Henrich; Susan E Bates; James B McMahon; Kirk R Gustafson
Flavonoids from eight tropical plant species that inhibit the multidrug resistance transporter ABCG2.
Journal of natural products 2011;74(2):262-6.
2011: Girma M Woldemichael; Thomas J Turbyville; W Marston Linehan; James B McMahon
Carminomycin I is an apoptosis inducer that targets the Golgi complex in clear cell renal carcinoma cells.
Cancer research 2011;71(1):134-42.
2010: Emily L Whitson; Cheryl L Thomas; Curtis J Henrich; Thomas J Sayers; James B McMahon; Tawnya C McKee
Clerodane diterpenes from Casearia arguta that act as synergistic TRAIL sensitizers.
Journal of natural products 2010;73(12):2013-8.
2010: Tinoush Moulaei; Shilpa R Shenoy; Barbara Giomarelli; Cheryl Thomas; James B McMahon; Zbigniew Dauter; Barry R O'Keefe; Alexander Wlodawer
Monomerization of viral entry inhibitor griffithsin elucidates the relationship between multivalent binding to carbohydrates and anti-HIV activity.
Structure (London, England : 1993) 2010;18(9):1104-15.
2010: Heidi R Bokesch; Laura K Cartner; Richard W Fuller; Jennifer A Wilson; Curtis J Henrich; James A Kelley; Kirk R Gustafson; James B McMahon; Tawnya C McKee
Inhibition of ABCG2-mediated drug efflux by naphthopyrones from marine crinoids.
Bioorganic & medicinal chemistry letters 2010;20(13):3848-50.
2010: Barry R O'Keefe; Barbara Giomarelli; Dale L Barnard; Shilpa R Shenoy; Paul K S Chan; James B McMahon; Kenneth Edward Palmer; Brian W Barnett; David K Meyerholz; Christine L Wohlford-Lenane; Paul B McCray
Broad-spectrum in vitro activity and in vivo efficacy of the antiviral protein griffithsin against emerging viruses of the family Coronaviridae.
Journal of virology 2010;84(5):2511-21.
2009: Curtis J Henrich; Robert W Robey; Kentaro Takada; Heidi R Bokesch; Susan E Bates; Suneet Shukla; Suresh V Ambudkar; James B McMahon; Kirk R Gustafson
Botryllamides: natural product inhibitors of ABCG2.
ACS chemical biology 2009;4(8):637-47.
2009: Sang-Moon Yun; Tinoush Moulaei; Dan Lim; Jeong K Bang; Jung-Eun Park; Shilpa R Shenoy; Fa Liu; Young H Kang; Chenzhong Liao; Nak-Kyun Soung; Sunhee Lee; Do-Young Yoon; Yoongho Lim; Dong-Hee Lee; Akira Otaka; Ettore Appella; James B McMahon; Marc C Nicklaus; Terrence R Burke; Michael B Yaffe; Alexander Wlodawer; Kyung S Lee
Structural and functional analyses of minimal phosphopeptides targeting the polo-box domain of polo-like kinase 1.
Nature structural & molecular biology 2009;16(8):876-82.
2009: Nancy Booth; Thomas J Sayers; Alan D Brooks; Cheryl L Thomas; Kristen Jacobsen; Ekaterina I Goncharova; James B McMahon; Curtis J Henrich
A cell-based high-throughput screen to identify synergistic TRAIL sensitizers.
Cancer immunology, immunotherapy : CII 2009;58(8):1229-44.
2009: Barry R O'Keefe; Fakhrieh Vojdani; Viviana Buffa; Robin J Shattock; David C Montefiori; James Bakke; Jon Mirsalis; Anna-Lisa d'Andrea; Steven D Hume; Barry Bratcher; Carrie J Saucedo; James B McMahon; Gregory P Pogue; Kenneth Edward Palmer
Scaleable manufacture of HIV-1 entry inhibitor griffithsin and validation of its safety and efficacy as a topical microbicide component.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(15):6099-104.
2009: Moon-Il Kang; Curtis J Henrich; Heidi R Bokesch; Kirk R Gustafson; James B McMahon; Alyson R Baker; Matthew R Young; Nancy H Colburn
A selective small-molecule nuclear factor-kappaB inhibitor from a high-throughput cell-based assay for "activator protein-1 hits".
Molecular cancer therapeutics 2009;8(3):571-81.
2008: Jason A Clement; Jirouta Kitagaki; Yili Yang; Carrie J Saucedo; Barry R O'Keefe; Allan M Weissman; Tawnya C McKee; James B McMahon
Discovery of new pyridoacridine alkaloids from Lissoclinum cf. badium that inhibit the ubiquitin ligase activity of Hdm2 and stabilize p53.
Bioorganic & medicinal chemistry 2008;16(23):10022-8.
2008: Christy A Sasiela; David H Stewart; Jirouta Kitagaki; Yassamin J Safiran; Yili Yang; Allan M Weissman; Pankaj Oberoi; Ilia V Davydov; Ekaterina Goncharova; John A Beutler; James B McMahon; Barry R O'Keefe
Identification of inhibitors for MDM2 ubiquitin ligase activity from natural product extracts by a novel high-throughput electrochemiluminescent screen.
Journal of biomolecular screening 2008;13(3):229-37.
2007: Curtis J Henrich; Robert W Robey; Heidi R Bokesch; Susan E Bates; Suneet Shukla; Suresh V Ambudkar; Michael Dean; James B McMahon
New inhibitors of ABCG2 identified by high-throughput screening.
Molecular cancer therapeutics 2007;6(12 Pt 1):3271-8.
2007: Kentaro Takada; Alun Bermingham; Barry R O'Keefe; Antony Wamiru; John A Beutler; Stuart F J Le Grice; John Lloyd; Kirk R Gustafson; James B McMahon
An HIV RNase H inhibitory 1,3,4,5-tetragalloylapiitol from the African plant Hylodendron gabunensis.
Journal of natural products 2007;70(10):1647-9.
2007: Peter Emau; Baoping Tian; Barry R O'Keefe; Toshiyuki Mori; James B McMahon; Kenneth Edward Palmer; Yonghou Jiang; G Bekele; Che-Chung Tsai
Griffithsin, a potent HIV entry inhibitor, is an excellent candidate for anti-HIV microbicide.
Journal of medical primatology 2007;36(4-5):244-53.
2007: Barbara Giomarelli; Valance A Washington; Maia M Chisholm; Laura Quigley; James B McMahon; Toshiyuki Mori; Daniel W McVicar
Inhibition of thrombin-induced platelet aggregation using human single-chain Fv antibodies specific for TREM-like transcript-1.
Thrombosis and haemostasis 2007;97(6):955-63.
2007: Robert L McFeeters; Changyun Xiong; Barry R O'Keefe; Heidi R Bokesch; James B McMahon; Daniel M Ratner; Riccardo Castelli; Peter H Seeberger; R Andrew Byrd
The novel fold of scytovirin reveals a new twist for antiviral entry inhibitors.
Journal of molecular biology 2007;369(2):451-61.
2007: Natasza E Ziółkowska; Shilpa R Shenoy; Barry R O'Keefe; James B McMahon; Kenneth Edward Palmer; Raymond A Dwek; Mark R Wormald; Alexander Wlodawer
Crystallographic, thermodynamic, and molecular modeling studies of the mode of binding of oligosaccharides to the potent antiviral protein griffithsin.
Proteins 2007;67(3):661-70.
2007: Curtis J Henrich; Ekaterina I Goncharova; Jennifer A Wilson; Roberta S Gardella; Tanya R Johnson; James B McMahon; Kentaro Takada; Heidi R Bokesch; Kirk R Gustafson
Natural products active in aberrant c-Kit signaling.
Chemical biology & drug design 2007;69(5):321-30.
2007: Nguyen Tien Dat; KiHwan Bae; Antony Wamiru; James B McMahon; Stuart F J Le Grice; Marion K Bona; John A Beutler; Young Ho Kim
A dimeric lactone from Ardisia japonica with inhibitory activity for HIV-1 and HIV-2 ribonuclease H.
Journal of natural products 2007;70(5):839-41.
2007: Kentaro Takada; Byoung W Choi; Mohammad A Rashid; William R Gamble; John H Cardellina; Que N Van; John R Lloyd; James B McMahon; Kirk R Gustafson
Structural assignment of poecillastrins B and C, macrolide lactams from the deep-water Caribbean sponge Poecillastra species.
Journal of natural products 2007;70(3):428-31.
2007: Katie M Ruocco; Ekaterina I Goncharova; Matthew R Young; Nancy H Colburn; James B McMahon; Curtis J Henrich
A high-throughput cell-based assay to identify specific inhibitors of transcription factor AP-1.
Journal of biomolecular screening 2007;12(1):133-9.
2007: Lauren R H Krumpe; Kathryn M Schumacher; James B McMahon; Lee Makowski; Toshiyuki Mori
Trinucleotide cassettes increase diversity of T7 phage-displayed peptide library.
BMC biotechnology 2007;7():65.
2006: Girma M Woldemichael; James R Vasselli; Roberta S Gardella; Tawnya C McKee; W Marston Linehan; James B McMahon
Development of a cell-based reporter assay for screening of inhibitors of hypoxia-inducible factor 2-induced gene expression.
Journal of biomolecular screening 2006;11(6):678-87.
2006: Lauren R H Krumpe; Andrew J Atkinson; Gary W Smythers; Andrea Kandel; Kathryn M Schumacher; James B McMahon; Lee Makowski; Toshiyuki Mori
T7 lytic phage-displayed peptide libraries exhibit less sequence bias than M13 filamentous phage-displayed peptide libraries.
Proteomics 2006;6(15):4210-22.
2006: Natasza E Ziółkowska; Barry R O'Keefe; Toshiyuki Mori; Charles Zhu; Barbara Giomarelli; Fakhrieh Vojdani; Kenneth Edward Palmer; James B McMahon; Alexander Wlodawer
Domain-swapped structure of the potent antiviral protein griffithsin and its mode of carbohydrate binding.
Structure (London, England : 1993) 2006;14(7):1127-35.
2006: Changyun Xiong; Barry R O'Keefe; R Andrew Byrd; James B McMahon
Potent anti-HIV activity of scytovirin domain 1 peptide.
Peptides 2006;27(7):1668-75.
2006: Barbara Giomarelli; Kathryn M Schumacher; Troy E Taylor; Raymond C Sowder; James L Hartley; James B McMahon; Toshiyuki Mori
Recombinant production of anti-HIV protein, griffithsin, by auto-induction in a fermentor culture.
Protein expression and purification 2006;47(1):194-202.
2006: Changyun Xiong; Barry R O'Keefe; Istvan Botos; Alexander Wlodawer; James B McMahon
Overexpression and purification of scytovirin, a potent, novel anti-HIV protein from the cultured cyanobacterium Scytonema varium.
Protein expression and purification 2006;46(2):233-9.
2006: Curtis J Henrich; Heidi R Bokesch; Michael Dean; Susan E Bates; Robert W Robey; Ekaterina I Goncharova; Jennifer A Wilson; James B McMahon
A high-throughput cell-based assay for inhibitors of ABCG2 activity.
Journal of biomolecular screening 2006;11(2):176-83.
2005: Naoya Oku; Ravi Krishnamoorthy; Alan G Benson; Robert L Ferguson; Mark A Lipton; Lawrence R Phillips; Kirk R Gustafson; James B McMahon
Complete stereochemistry of neamphamide A and absolute configuration of the beta-methoxytyrosine residue in papuamide B.
The Journal of organic chemistry 2005;70(17):6842-7.
2005: Toshiyuki Mori; Barry R O'Keefe; Raymond C Sowder; Scott D Bringans; Roberta S Gardella; Shannon Berg; Pamela Cochran; Jim A Turpin; Robert W Buckheit; James B McMahon; Michael R Boyd
Isolation and characterization of griffithsin, a novel HIV-inactivating protein, from the red alga Griffithsia sp.
The Journal of biological chemistry 2005;280(10):9345-53.
2005: Scott R Budihas; Inna I Gorshkova; Sergei A Gaidamakov; Antony Wamiru; Marion K Bona; Michael A Parniak; Robert J Crouch; James B McMahon; John A Beutler; Stuart F J Le Grice
Selective inhibition of HIV-1 reverse transcriptase-associated ribonuclease H activity by hydroxylated tropolones.
Nucleic acids research 2005;33(4):1249-56.
2004: King C Chan; Scott R Budihas; Stuart F J Le Grice; Michael A Parniak; Robert J Crouch; Sergei A Gaidamakov; Haleem J Isaaq; Antony Wamiru; James B McMahon; John A Beutler
A capillary electrophoretic assay for ribonuclease H activity.
Analytical biochemistry 2004;331(2):296-302.
2004: Naoya Oku; Kirk R Gustafson; Laura K Cartner; Jennifer A Wilson; Nobuharu Shigematsu; Sonja Hess; Lewis K Pannell; Michael R Boyd; James B McMahon
Neamphamide A, a new HIV-inhibitory depsipeptide from the Papua New Guinea marine sponge Neamphius huxleyi.
Journal of natural products 2004;67(8):1407-11.
2004: Karina M Meragelman; Tawnya C McKee; James B McMahon
Monanchorin, a bicyclic alkaloid from the sponge Monanchora ungiculata.
Journal of natural products 2004;67(7):1165-7.
2004: Heidi R Bokesch; Romila D Charan; Karina M Meragelman; John A Beutler; Roberta S Gardella; Barry R O'Keefe; Tawnya C McKee; James B McMahon
Isolation and characterization of anti-HIV peptides from Dorstenia contrajerva and Treculia obovoidea.
FEBS letters 2004;567(2-3):287-90.
2004: Eddie W Adams; Daniel M Ratner; Heidi R Bokesch; James B McMahon; Barry R O'Keefe; Peter H Seeberger
Oligosaccharide and glycoprotein microarrays as tools in HIV glycobiology; glycan-dependent gp120/protein interactions.
Chemistry & biology 2004;11(6):875-81.
2004: Dennis J Milanowski; Kirk R Gustafson; Mohammad A Rashid; Lewis K Pannell; James B McMahon; Michael R Boyd
Gymnangiamide, a cytotoxic pentapeptide from the marine hydroid Gymnangium regae.
The Journal of organic chemistry 2004;69(9):3036-42.
2004: Dennis J Milanowski; Kirk R Gustafson; James A Kelley; James B McMahon
Caulibugulones A-F, novel cytotoxic isoquinoline quinones and iminoquinones from the marine bryozoan Caulibugula intermis.
Journal of natural products 2004;67(1):70-3.
2002: George R Pettit; Sylvie Ducki; Rui Tan; Roberta S Gardella; James B McMahon; Michael R Boyd; George R Pettit; Peter M Blumberg; Nancy E Lewin; Dennis L Doubek; Larry P Tackett; Michael D Williams
Isolation and structure of pedilstatin from a republic of maldives Pedilanthus sp.
Journal of natural products 2002;65(9):1262-5.
2002: Barbara Giomarelli; Roberta Provvedi; Francesca Meacci; Tiziana Maggi; Donata Medaglini; Gianni Pozzi; Toshiyuki Mori; James B McMahon; Roberta S Gardella; Michael R Boyd
The microbicide cyanovirin-N expressed on the surface of commensal bacterium Streptococcus gordonii captures HIV-1.
AIDS (London, England) 2002;16(10):1351-6.
2002: John A Beutler; James B McMahon; Tanya R Johnson; Barry R O'Keefe; Randy A Buzzell; Danielle Robbins; Roberta S Gardella; Jennifer Wilson; Michael R Boyd
High throughput screening for cyanovirin-N mimetics binding to HIV-1 gp41.
Journal of biomolecular screening 2002;7(2):105-10.
2001: Anders Bolmstedt; Barry R O'Keefe; Shilpa R Shenoy; James B McMahon; Michael R Boyd
Cyanovirin-N defines a new class of antiviral agent targeting N-linked, high-mannose glycans in an oligosaccharide-specific manner.
Molecular pharmacology 2001;59(5):949-54.
2000: James B McMahon; John A Beutler; Barry R O'Keefe; C B Goodrum; M A Myers; Michael R Boyd
Development of a cyanovirin-N-HIV-1 gp120 binding assay for high throughput screening of natural product extracts by time-resolved fluorescence.
Journal of biomolecular screening 2000;5(3):169-76.
1998: J M Mariner; James B McMahon; Barry R O'Keefe; K Nagashima; Michael R Boyd
The HIV-inactivating protein, cyanovirin-N, does not block gp120-mediated virus-to-cell binding.
Biochemical and biophysical research communications 1998;248(3):841-5.
1998: Barry R O'Keefe; T Erim; John A Beutler; John H Cardellina; RJ Gulakowski; BL Krepps; James B McMahon; Raymond C Sowder; Donald G Johnson; Robert W Buckheit; S Halliday; Michael R Boyd
Isolation and characterization of adociavirin, a novel HIV-inhibitory protein from the sponge Adocia sp.
FEBS letters 1998;431(1):85-90.
1998: T Mori; Kirk R Gustafson; Lewis K Pannell; Robert H Shoemaker; L Wu; James B McMahon; Michael R Boyd
Recombinant production of cyanovirin-N, a potent human immunodeficiency virus-inactivating protein derived from a cultured cyanobacterium.
Protein expression and purification 1998;12(2):151-8.
1997: T Mori; Robert H Shoemaker; James B McMahon; RJ Gulakowski; Kirk R Gustafson; Michael R Boyd
Construction and enhanced cytotoxicity of a [cyanovirin-N]-[Pseudomonas exotoxin] conjugate against human immunodeficiency virus-infected cells.
Biochemical and biophysical research communications 1997;239(3):884-8.
1997: Kirk R Gustafson; Raymond C Sowder; Louis E. Henderson; John H Cardellina; James B McMahon; U Rajamani; Lewis K Pannell; Michael R Boyd
Isolation, primary sequence determination, and disulfide bond structure of cyanovirin-N, an anti-HIV (human immunodeficiency virus) protein from the cyanobacterium Nostoc ellipsosporum.
Biochemical and biophysical research communications 1997;238(1):223-8.
1997: T Mori; Robert H Shoemaker; RJ Gulakowski; BL Krepps; James B McMahon; Kirk R Gustafson; Lewis K Pannell; Michael R Boyd
Analysis of sequence requirements for biological activity of cyanovirin-N, a potent HIV (human immunodeficiency virus)-inactivating protein.
Biochemical and biophysical research communications 1997;238(1):218-22.
1997: Yali F Hallock; K P Manfredi; JR Dai; John H Cardellina; RJ Gulakowski; James B McMahon; M Schäffer; M Stahl; K P Gulden; G Bringmann; G François; Michael R Boyd
Michellamines D-F, new HIV-inhibitory dimeric naphthylisoquinoline alkaloids, and korupensamine E, a new antimalarial monomer, from Ancistrocladus korupensis.
Journal of natural products 1997;60(7):677-83.
1997: Michael R Boyd; Kirk R Gustafson; James B McMahon; Robert H Shoemaker; Barry R O'Keefe; T Mori; RJ Gulakowski; L Wu; M I Rivera; C M Laurencot; Michael J Currens; John H Cardellina; Robert W Buckheit; P L Nara; Lewis K Pannell; Raymond C Sowder; Louis E. Henderson
Discovery of cyanovirin-N, a novel human immunodeficiency virus-inactivating protein that binds viral surface envelope glycoprotein gp120: potential applications to microbicide development.
Antimicrobial agents and chemotherapy 1997;41(7):1521-30.
1997: Barry R O'Keefe; John A Beutler; John H Cardellina; RJ Gulakowski; BL Krepps; James B McMahon; Raymond C Sowder; Louis E. Henderson; Lewis K Pannell; Shirley Pomponi; Michael R Boyd
Isolation and characterization of niphatevirin, a human-immunodeficiency-virus-inhibitory glycoprotein from the marine sponge Niphates erecta.
European journal of biochemistry / FEBS 1997;245(1):47-53.
1997: RJ Gulakowski; James B McMahon; Robert W Buckheit; Kirk R Gustafson; Michael R Boyd
Antireplicative and anticytopathic activities of prostratin, a non-tumor-promoting phorbol ester, against human immunodeficiency virus (HIV).
Antiviral research 1997;33(2):87-97.
1996: M J Currens; J M Mariner; James B McMahon; Michael R Boyd
Kinetic analysis of inhibition of human immunodeficiency virus type-1 reverse transcriptase by calanolide A.
The Journal of pharmacology and experimental therapeutics 1996;279(2):652-61.
1996: M J Currens; RJ Gulakowski; J M Mariner; R A Moran; Robert W Buckheit; Kirk R Gustafson; James B McMahon; Michael R Boyd
Antiviral activity and mechanism of action of calanolide A against the human immunodeficiency virus type-1.
The Journal of pharmacology and experimental therapeutics 1996;279(2):645-51.
1996: D L Galinis; RW Fuller; Tawnya C McKee; John H Cardellina; RJ Gulakowski; James B McMahon; Michael R Boyd
Structure-activity modifications of the HIV-1 inhibitors (+)-calanolide A and (-)-calanolide B.
Journal of medicinal chemistry 1996;39(22):4507-10.
1996: Tawnya C McKee; RW Fuller; C D Covington; John H Cardellina; RJ Gulakowski; B L Krepps; James B McMahon; Michael R Boyd
New pyranocoumarins isolated from Calophyllum lanigerum and Calophyllum teysmannii.
Journal of natural products 1996;59(8):754-8.
1996: James B McMahon; Robert W Buckheit; RJ Gulakowski; M J Currens; D T Vistica; Robert H Shoemaker; S F Stinson; Julie D Russell; JP Bader; V L Narayanan; R J Schultz; W G Brouwer; E E Felauer; Michael R Boyd
Biological and biochemical anti-human immunodeficiency virus activity of UC 38, a new non-nucleoside reverse transcriptase inhibitor.
The Journal of pharmacology and experimental therapeutics 1996;276(1):298-305.
1995: K L Erickson; John A Beutler; John H Cardellina; James B McMahon; David Newman; Michael R Boyd
A novel phorbol ester from Excoecaria agallocha.
Journal of natural products 1995;58(5):769-72.
1995: Robert W Buckheit; V Fliakas-Boltz; W D Decker; J L Roberson; TL Stup; C A Pyle; E Lucile White; James B McMahon; M J Currens; Michael R Boyd
Comparative anti-HIV evaluation of diverse HIV-1-specific reverse transcriptase inhibitor-resistant virus isolates demonstrates the existence of distinct phenotypic subgroups.
Antiviral research 1995;26(2):117-32.
1995: James B McMahon; M J Currens; RJ Gulakowski; Robert W Buckheit; C Lackman-Smith; Yali F Hallock; Michael R Boyd
Michellamine B, a novel plant alkaloid, inhibits human immunodeficiency virus-induced cell killing by at least two distinct mechanisms.
Antimicrobial agents and chemotherapy 1995;39(2):484-8.
1994: Mark Cushman; W M Golebiewski; James B McMahon; Robert W Buckheit; D J Clanton; O Weislow; R D Haugwitz; J P Bader; L Graham; William G Rice
Design, synthesis, and biological evaluation of cosalane, a novel anti-HIV agent which inhibits multiple features of virus reproduction.
Journal of medicinal chemistry 1994;37(19):3040-50.
1994: Robert W Buckheit; V Fliakas-Boltz; W D Decker; J L Roberson; C A Pyle; E Lucile White; B J Bowdon; James B McMahon; Michael R Boyd; JP Bader
Biological and biochemical anti-HIV activity of the benzothiadiazine class of nonnucleoside reverse transcriptase inhibitors.
Antiviral research 1994;25(1):43-56.
1994: T Rubinek; James B McMahon; Amnon Hizi
Inhibition of reverse transcriptase of human immunodeficiency virus type 1 and chimeric enzymes of human immunodeficiency viruses types 1 and 2 by two novel non-nucleoside inhibitors.
FEBS letters 1994;350(2-3):299-303.
1994: Michael R Boyd; Yali F Hallock; John H Cardellina; K P Manfredi; J W Blunt; James B McMahon; Robert W Buckheit; Gerhard Bringmann; M Schäffer; Gordon M Cragg
Anti-HIV michellamines from Ancistrocladus korupensis.
Journal of medicinal chemistry 1994;37(12):1740-5.
1994: Tawnya C McKee; John H Cardellina; Raffaele Riccio; M V D'Auria; Maria Iorizzi; L Minale; R A Moran; RJ Gulakowski; James B McMahon; Robert W Buckheit
HIV-inhibitory natural products. 11. Comparative studies of sulfated sterols from marine invertebrates.
Journal of medicinal chemistry 1994;37(6):793-7.
1993: Robert W Buckheit; Melinda G Hollingshead; J Germany-Decker; E Lucile White; James B McMahon; L B Allen; L J Ross; W D Decker; L Westbrook; W M Shannon
Thiazolobenzimidazole: biological and biochemical anti-retroviral activity of a new nonnucleoside reverse transcriptase inhibitor.
Antiviral research 1993;21(3):247-65.
1993: Amnon Hizi; R Tal; M Shaharabany; M J Currens; Michael R Boyd; Stephen H Hughes; James B McMahon
Specific inhibition of the reverse transcriptase of human immunodeficiency virus type 1 and the chimeric enzymes of human immunodeficiency virus type 1 and type 2 by nonnucleoside inhibitors.
Antimicrobial agents and chemotherapy 1993;37(5):1037-42.
1993: James B McMahon; RJ Gulakowski; O S Weislow; R J Schultz; V L Narayanan; D J Clanton; R Pedemonte; F W Wassmundt; Robert W Buckheit; W D Decker
Diarylsulfones, a new chemical class of nonnucleoside antiviral inhibitors of human immunodeficiency virus type 1 reverse transcriptase.
Antimicrobial agents and chemotherapy 1993;37(4):754-60.
1993: Paul L Boyer; M J Currens; James B McMahon; Michael R Boyd; Stephen H Hughes
Analysis of nonnucleoside drug-resistant variants of human immunodeficiency virus type 1 reverse transcriptase.
Journal of virology 1993;67(4):2412-20.
1992: Yoel Kashman; Kirk R Gustafson; RW Fuller; John H Cardellina; James B McMahon; M J Currens; Robert W Buckheit; Stephen H Hughes; Gordon M Cragg; Michael R Boyd
The calanolides, a novel HIV-inhibitory class of coumarin derivatives from the tropical rainforest tree, Calophyllum lanigerum.
Journal of medicinal chemistry 1992;35(15):2735-43.
1992: Kirk R Gustafson; John H Cardellina; James B McMahon; RJ Gulakowski; J Ishitoya; Z Szallasi; Nancy E Lewin; P M Blumberg; O S Weislow; John A Beutler
A nonpromoting phorbol from the samoan medicinal plant Homalanthus nutans inhibits cell killing by HIV-1.
Journal of medicinal chemistry 1992;35(11):1978-86.
1992: John A Beutler; John H Cardellina; James B McMahon; Michael R Boyd; Gordon M Cragg
Anti-HIV and cytotoxic alkaloids from Buchenavia capitata.
Journal of natural products 1992;55(2):207-13.
1992: D J Clanton; R A Moran; James B McMahon; O S Weislow; Robert W Buckheit; Melinda G Hollingshead; Vincenzo Ciminale; Barbara K Felber; G N Pavlakis; JP Bader
Sulfonic acid dyes: inhibition of the human immunodeficiency virus and mechanism of action.
Journal of acquired immune deficiency syndromes 1992;5(8):771-81.
1991: K P Manfredi; J W Blunt; John H Cardellina; James B McMahon; L L Pannell; Gordon M Cragg; Michael R Boyd
Novel alkaloids from the tropical plant Ancistrocladus abbreviatus inhibit cell killing by HIV-1 and HIV-2.
Journal of medicinal chemistry 1991;34(12):3402-5.
1991: JP Bader; James B McMahon; R J Schultz; V L Narayanan; J B Pierce; W A Harrison; O S Weislow; C F Midelfort; S F Stinson; Michael R Boyd
Oxathiin carboxanilide, a potent inhibitor of human immunodeficiency virus reproduction.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(15):6740-4.
1991: RJ Gulakowski; James B McMahon; P G Staley; R A Moran; Michael R Boyd
A semiautomated multiparameter approach for anti-HIV drug screening.
Journal of virological methods 1991;33(1-2):87-100.