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Trevor McMorris

Research Profile

Chemicals & Drugs

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TOP 3
Trevor C McMorris; Ramesh Chimmani; Kashinatham Alisala; Michael D Staake; Gangadasu Banda; Michael J Kelner
Structure-activity studies of urea, carbamate, and sulfonamide derivatives of acylfulvene.
Michael J Kelner; Trevor C McMorris; Rafael J Rojas; Leita A Estes; Pharnuk Suthipinijtham
Synergy of irofulven in combination with other DNA damaging agents: synergistic interaction with altretamine, alkylating, and platinum-derived agents in the MV522 lung tumor model.
Michael J Kelner; Trevor C McMorris; Rafael J Rojas; Leita A Estes; Pharnuk Suthipinijtham
Synergy of Irofulven in combination with various anti-metabolites, enzyme inhibitors, and miscellaneous agents in MV522 lung carcinoma cells: marked interaction with gemcitabine and 5-fluorouracil.

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All Publications

2010: Trevor C McMorris; Ramesh Chimmani; Kashinatham Alisala; Michael D Staake; Gangadasu Banda; Michael J Kelner
Structure-activity studies of urea, carbamate, and sulfonamide derivatives of acylfulvene.
Journal of medicinal chemistry 2010;53(3):1109-16.
2008: Michael J Kelner; Trevor C McMorris; Rafael J Rojas; Leita A Estes; Pharnuk Suthipinijtham
Synergy of irofulven in combination with other DNA damaging agents: synergistic interaction with altretamine, alkylating, and platinum-derived agents in the MV522 lung tumor model.
Cancer chemotherapy and pharmacology 2008;63(1):19-26.
2008: Michael J Kelner; Trevor C McMorris; Rafael J Rojas; Leita A Estes; Pharnuk Suthipinijtham
Synergy of Irofulven in combination with various anti-metabolites, enzyme inhibitors, and miscellaneous agents in MV522 lung carcinoma cells: marked interaction with gemcitabine and 5-fluorouracil.
Investigational new drugs 2008;26(5):407-15.
2007: Trevor C McMorris; Ramesh Chimmani; Mahender Gurram; Michael D Staake; Michael J Kelner
Synthesis and antitumor activity of amine analogs of irofulven.
Bioorganic & medicinal chemistry letters 2007;17(24):6770-2.
2004: Trevor C McMorris; Michael D Staake; Michael J Kelner
Synthesis and biological activity of enantiomers of antitumor irofulven.
The Journal of organic chemistry 2004;69(3):619-23.
2003: Trevor C McMorris; Qiang Cong; Michael J Kelner
Structure-activity relationship studies of illudins: analogues possessing a spiro-cyclobutane ring.
The Journal of organic chemistry 2003;68(25):9648-53.
2003: Chimmani Ramesh; Nasi Ravindranath; Biswanath Das; Anabathula Prabhakar; Jagadeesh Bharatam; Krishnan Ravikumar; A Kashinatham; Trevor C McMorris
Pseudoguaianolides from the flowers of Parthenium hysterophorus.
Phytochemistry 2003;64(4):841-4.
2003: Trevor C McMorris; Surk-Sik Moon; Michael J Kelner
Reaction of irofulven with zinc and acid.
Journal of natural products 2003;66(2):310-2.
2002: Nicolaas G J Jaspers; Anja Raams; Michael J Kelner; Jessica M Y Ng; yukiko yamashita; Shiunichi Takeda; Trevor C McMorris; Jan H J Hoeijmakers
Anti-tumour compounds illudin S and Irofulven induce DNA lesions ignored by global repair and exclusively processed by transcription- and replication-coupled repair pathways.
DNA repair 2002;1(12):1027-38.
2002: Trevor C McMorris; Michael D Staake
Resolution of both enantiomers of 5-chloro-5-methyl-2-cyclopentenone.
The Journal of organic chemistry 2002;67(22):7902-3.
2002: Trevor C McMorris; A Kashinatham; Ricardo Lira; Henrik Rundgren; Peter Gantzel; Michael J Kelner; Robin Dawe
Sesquiterpenes from Omphalotus illudens.
Phytochemistry 2002;61(4):395-8.
2002: Michael J Kelner; Trevor C McMorris; Rafael J Rojas; Nicole A Trani; Tami R Velasco; Leita A Estes; Pharnuk Suthipinijtham
Enhanced antitumor activity of irofulven in combination with antimitotic agents.
Investigational new drugs 2002;20(3):271-9.
2002: Michael J Kelner; Trevor C McMorris; Rafael J Rojas; Nicole A Trani; Leita A Estes
Enhanced antitumor activity of irofulven in combination with thiotepa or mitomycin C.
Cancer chemotherapy and pharmacology 2002;49(5):412-8.
2001: Trevor C McMorris; J Yu; Ricardo Lira; Robin Dawe; John R MacDonald; Stephen J Waters; Leita A Estes; Michael J Kelner
Structure-activity studies of antitumor agent irofulven (hydroxymethylacylfulvene) and analogues.
The Journal of organic chemistry 2001;66(18):6158-63.
2000: Trevor C McMorris; Ricardo Lira; Peter Gantzel; Michael J Kelner; Robin Dawe
Sesquiterpenes from the basidiomycete Omphalotus illudens.
Journal of natural products 2000;63(11):1557-9.
2000: Trevor C McMorris; J Yu; H T Ngo; H Wang; Michael J Kelner
Preparation and biological activity of amino acid and peptide conjugates of antitumor hydroxymethylacylfulvene.
Journal of medicinal chemistry 2000;43(19):3577-80.
2000: Michael J Kelner; Trevor C McMorris; Leita A Estes; M Y Oval; Rafael J Rojas; J R Lynn; K A Lanham; KM Samson
Efficacy of MGI 114 (HMAF) against the MRP+ metastatic MV522 lung carcinoma xenograft.
Anti-cancer drugs 2000;11(3):217-24.
2000: Michael J Kelner; Trevor C McMorris; Leita A Estes; KM Samson; Nicole A Trani; John R MacDonald
Anti-leukemic action of the novel agent MGI 114 (HMAF) and synergistic action with topotecan.
Leukemia 2000;14(1):136-41.
1999: Trevor C McMorris; A N Elayadi; J Yu; Y Hu; Michael J Kelner
Metabolism of antitumor hydroxymethylacylfulvene by rat liver cytosol.
Drug metabolism and disposition: the biological fate of chemicals 1999;27(9):983-5.
1999: Trevor C McMorris
Discovery and development of sesquiterpenoid derived hydroxymethylacylfulvene: a new anticancer drug.
Bioorganic & medicinal chemistry 1999;7(5):881-6.
1999: Michael J Kelner; Trevor C McMorris; MA Montoya; Leita A Estes; SF Uglik; M Rutherford; KM Samson; Richard D Bagnell; R Taetle
Characterization of MGI 114 (HMAF) histiospecific toxicity in human tumor cell lines.
Cancer chemotherapy and pharmacology 1999;44(3):235-40.
1999: Trevor C McMorris; A N Elayadi; J Yu; Michael J Kelner
Metabolism of antitumor acylfulvene by rat liver cytosol.
Biochemical pharmacology 1999;57(1):83-8.
1998: Michael J Kelner; Trevor C McMorris; Leita A Estes; KM Samson; Richard D Bagnell; R Taetle
Efficacy of MGI 114 (6-hydroxymethylacylfulvene, HMAF) against the mdr1/gp170 metastatic MV522 lung carcinoma xenograft.
European journal of cancer (Oxford, England : 1990) 1998;34(6):908-13.
1998: Michael J Kelner; Trevor C McMorris; MA Montoya; Leita A Estes; SF Uglik; M Rutherford; KM Samson; Richard D Bagnell; R Taetle
Characterization of acylfulvene histiospecific toxicity in human tumor cell lines.
Cancer chemotherapy and pharmacology 1998;41(3):237-42.
1997: Trevor C McMorris
Recent developments in the field of plant steroid hormones.
Lipids 1997;32(12):1303-8.
1997: John R MacDonald; C C Muscoplat; D L Dexter; Gina L Mangold; S F Chen; Michael J Kelner; Trevor C McMorris; Daniel Von Hoff
Preclinical antitumor activity of 6-hydroxymethylacylfulvene, a semisynthetic derivative of the mushroom toxin illudin S.
Cancer research 1997;57(2):279-83.
1997: Michael J Kelner; Trevor C McMorris; MA Montoya; Leita A Estes; M Rutherford; KM Samson; R Taetle
Characterization of cellular accumulation and toxicity of illudin S in sensitive and nonsensitive tumor cells.
Cancer chemotherapy and pharmacology 1997;40(1):65-71.
1996: Trevor C McMorris; Michael J Kelner; W Wang; J Yu; Leita A Estes; R Taetle
(Hydroxymethyl)acylfulvene: an illudin derivative with superior antitumor properties.
Journal of natural products 1996;59(9):896-9.
1996: Trevor C McMorris; Michael J Kelner; W Wang; M A Diaz; Leita A Estes; R Taetle
Acylfulvenes, a new class of potent antitumor agents.
Experientia 1996;52(1):75-80.
1996: M J Kelner; Trevor C McMorris; Leita A Estes; W Wang; KM Samson; R Taetle
Efficacy of HMAF (MGI-114) in the MV522 metastatic lung carcinoma xenograft model nonresponsive to traditional anticancer agents.
Investigational new drugs 1996;14(2):161-7.
1995: Michael J Kelner; Trevor C McMorris; Leita A Estes; R J Starr; M Rutherford; M Montoya; KM Samson; R Taetle
Efficacy of Acylfulvene Illudin analogues against a metastatic lung carcinoma MV522 xenograft nonresponsive to traditional anticancer agents: retention of activity against various mdr phenotypes and unusual cytotoxicity against ERCC2 and ERCC3 DNA helicase-deficient cells.
Cancer research 1995;55(21):4936-40.
1995: Michael J Kelner; Trevor C McMorris; R Taetle
In vitro and in vivo studies on the anticancer activity of dehydroilludin M.
Anticancer research 1995;15(3):873-8.
1995: Michael J Kelner; Trevor C McMorris; Leita A Estes; R Starr; KM Samson; N Varki; R Taetle
Nonresponsiveness of the metastatic human lung carcinoma MV522 xenograft to conventional anticancer agents.
Anticancer research 1995;15(3):867-71.
1994: Michael J Kelner; Trevor C McMorris; Leita A Estes; M Rutherford; MA Montoya; J Goldstein; KM Samson; R Starr; R Taetle
Characterization of illudin S sensitivity in DNA repair-deficient Chinese hamster cells. Unusually high sensitivity of ERCC2 and ERCC3 DNA helicase-deficient mutants in comparison to other chemotherapeutic agents.
Biochemical pharmacology 1994;48(2):403-9.
1992: Eva Brandsteterová; Michael J Kelner; Trevor C McMorris; Leita A Estes; Richard D Bagnell; MA Montoya
HPLC determination of a new anticancer agent (acylfulvene) in serum.
Neoplasma 1992;39(6):369-73.
1990: Trevor C McMorris; Michael J Kelner; W Wang; S Moon; R Taetle
On the mechanism of toxicity of illudins: the role of glutathione.
Chemical research in toxicology 1990;3(6):574-9.
1990: Michael J Kelner; Trevor C McMorris; R Taetle
Preclinical evaluation of illudins as anticancer agents: basis for selective cytotoxicity.
Journal of the National Cancer Institute 1990;82(19):1562-5.
1989: Trevor C McMorris; P H Le; M W Preus; S R Schow; G R Weihe
Synthesis of dehydro-oogoniol, a female-activating hormone of Achlya: the progesterone route.
Steroids 1989;53(3-5):345-61.
1987: Michael J Kelner; Trevor C McMorris; William T Beck; J M Zamora; R Taetle
Preclinical evaluation of illudins as anticancer agents.
Cancer research 1987;47(12):3186-9.
1981: G R Weihe; Trevor C McMorris
Conversion of 15 alpha-hydroxy-11-oxo-progesterone to 3 beta, 11 alpha, 15 beta-trihydroxy-5-pregnen-20-one.
Steroids 1981;37(3):291-301.