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Ian McPhee

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Colin Moran; Nicholas D Barwell; Dalia Malkova; Stephen J Cleland; Ian McPhee; Chris J Packard; Victor A Zammit; Jason M R Gill
Effects of diabetes family history and exercise training on the expression of adiponectin and leptin and their receptors.
Lucien C D Gibson; Stuart F Hastings; Ian McPhee; Robert A Clayton; Clare E Darroch; Alison Mackenzie; Fiona L Mackenzie; Michiaki Nagasawa; Patricia A Stevens; Simon MacKenzie
The inhibitory profile of Ibudilast against the human phosphodiesterase enzyme family.
Ian McPhee; Lucien C D Gibson; J Kewney; Clare E Darroch; P A Stevens; Daniel Spinks; A Cooreman; Simon MacKenzie
Cyclic nucleotide signalling: a molecular approach to drug discovery for Alzheimer's disease.

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All Publications

2011: Colin Moran; Nicholas D Barwell; Dalia Malkova; Stephen J Cleland; Ian McPhee; Chris J Packard; Victor A Zammit; Jason M R Gill
Effects of diabetes family history and exercise training on the expression of adiponectin and leptin and their receptors.
Metabolism: clinical and experimental 2011;60(2):206-14.
2006: Lucien C D Gibson; Stuart F Hastings; Ian McPhee; Robert A Clayton; Clare E Darroch; Alison Mackenzie; Fiona L Mackenzie; Michiaki Nagasawa; Patricia A Stevens; Simon MacKenzie
The inhibitory profile of Ibudilast against the human phosphodiesterase enzyme family.
European journal of pharmacology 2006;538(1-3):39-42.
2005: Ian McPhee; Lucien C D Gibson; J Kewney; Clare E Darroch; P A Stevens; Daniel Spinks; A Cooreman; Simon MacKenzie
Cyclic nucleotide signalling: a molecular approach to drug discovery for Alzheimer's disease.
Biochemical Society transactions 2005;33(Pt 6):1330-2.
2004: Eric Livingston; Clare E Darroch; Rekha Chaudhuri; Ian McPhee; Alex D McMahon; Simon MacKenzie; Neil C Thomson
Glucocorticoid receptor alpha:beta ratio in blood mononuclear cells is reduced in cigarette smokers.
The Journal of allergy and clinical immunology 2004;114(6):1475-8.
2003: George S Baillie; Arvind Sood; Ian McPhee; Irene Gall; Stephen J Perry; Robert J Lefkowitz; Miles D Houslay
beta-Arrestin-mediated PDE4 cAMP phosphodiesterase recruitment regulates beta-adrenoceptor switching from Gs to Gi.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(3):940-5.
2002: Stephen J Perry; George S Baillie; Trudy A Kohout; Ian McPhee; Maria M Magiera; Kok Long Ang; William E Miller; Alison J McLean; Marco Conti; Miles D Houslay; Robert J Lefkowitz
Targeting of cyclic AMP degradation to beta 2-adrenergic receptors by beta-arrestins.
Science (New York, N.Y.) 2002;298(5594):834-6.
2002: Simon MacKenzie; George S Baillie; Ian McPhee; Carolynn MacKenzie; Rachael Seamons; Theresa McSorley; Jennifer Millen; Matthew B Beard; Gino van Heeke; Miles D Houslay
Long PDE4 cAMP specific phosphodiesterases are activated by protein kinase A-mediated phosphorylation of a single serine residue in Upstream Conserved Region 1 (UCR1).
British journal of pharmacology 2002;136(3):421-33.
2002: Matthew B Beard; Elaine Huston; Lachlan Campbell; Irene Gall; Ian McPhee; Stephen J Yarwood; Grant Scotland; Miles D Houslay
In addition to the SH3 binding region, multiple regions within the N-terminal noncatalytic portion of the cAMP-specific phosphodiesterase, PDE4A5, contribute to its intracellular targeting.
Cellular signalling 2002;14(5):453-65.
2001: Ian McPhee; S Cochran; Miles D Houslay
The novel long PDE4A10 cyclic AMP phosphodiesterase shows a pattern of expression within brain that is distinct from the long PDE4A5 and short PDE4A1 isoforms.
Cellular signalling 2001;13(12):911-8.
2001: G Rena; F Begg; A Ross; Carolynn MacKenzie; Ian McPhee; Lachlan Campbell; Elaine Huston; Michael Sullivan; Miles D Houslay
Molecular cloning, genomic positioning, promoter identification, and characterization of the novel cyclic amp-specific phosphodiesterase PDE4A10.
Molecular pharmacology 2001;59(5):996-1011.
2000: George S Baillie; Simon MacKenzie; Ian McPhee; Miles D Houslay
Sub-family selective actions in the ability of Erk2 MAP kinase to phosphorylate and regulate the activity of PDE4 cyclic AMP-specific phosphodiesterases.
British journal of pharmacology 2000;131(4):811-9.
2000: Ian McPhee; Miles D Houslay; Stephen J Yarwood
Use of an activation-specific probe to show that Rap1A and Rap1B display different sensitivities to activation by forskolin in rat1 cells.
FEBS letters 2000;477(3):213-8.
2000: Simon MacKenzie; George S Baillie; Ian McPhee; Graeme B Bolger; Miles D Houslay
ERK2 mitogen-activated protein kinase binding, phosphorylation, and regulation of the PDE4D cAMP-specific phosphodiesterases. The involvement of COOH-terminal docking sites and NH2-terminal UCR regions.
The Journal of biological chemistry 2000;275(22):16609-17.
1999: Ian McPhee; Stephen J Yarwood; Grant Scotland; Elaine Huston; Matthew B Beard; AH Ross; Emma S Houslay; Miles D Houslay
Association with the SRC family tyrosyl kinase LYN triggers a conformational change in the catalytic region of human cAMP-specific phosphodiesterase HSPDE4A4B. Consequences for rolipram inhibition.
The Journal of biological chemistry 1999;274(17):11796-810.
1997: Miles D Houslay; Grant Scotland; Suat Erdogan; Elaine Huston; Simon MacKenzie; J F McCallum; Ian McPhee; L Pooley; G Rena; A Ross; Matthew B Beard; A Peder; F Begg; I Wilkinson; Stephen J Yarwood; C Ackerman; Emma S Houslay; R Hoffman; P Engels; Michael Sullivan; Graeme B Bolger
Intracellular targeting, interaction with Src homology 3 (SH3) domains and rolipram-detected conformational switches in cAMP-specific PDE4A phosphodiesterase.
Biochemical Society transactions 1997;25(2):374-81.
1996: Elaine Huston; L Pooley; P Julien; Grant Scotland; Ian McPhee; Michael Sullivan; Graeme B Bolger; Miles D Houslay
The human cyclic AMP-specific phosphodiesterase PDE-46 (HSPDE4A4B) expressed in transfected COS7 cells occurs as both particulate and cytosolic species that exhibit distinct kinetics of inhibition by the antidepressant rolipram.
The Journal of biological chemistry 1996;271(49):31334-44.
1996: J C O'Connell; J F McCallum; Ian McPhee; J Wakefield; E S Houslay; W Wishart; Graeme B Bolger; M Frame; Miles D Houslay
The SH3 domain of Src tyrosyl protein kinase interacts with the N-terminal splice region of the PDE4A cAMP-specific phosphodiesterase RPDE-6 (RNPDE4A5).
The Biochemical journal 1996;318 ( Pt 1)():255-61.
1995: Ian McPhee; L Pooley; M Lobban; Graeme B Bolger; Miles D Houslay
Identification, characterization and regional distribution in brain of RPDE-6 (RNPDE4A5), a novel splice variant of the PDE4A cyclic AMP phosphodiesterase family.
The Biochemical journal 1995;310 ( Pt 3)():965-74.