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Kirk McPherson

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Jeffrey W Corbett; Kevin D Freeman-Cook; Richard Elliott; Felix Vajdos; Francis Rajamohan; Darcy Kohls; Eric Marr; Hailong Zhang; Liang Tong; Meihua Tu; Sharad Murdande; Shawn D Doran; Janet A Houser; Wei Song; Christopher J Jones; Steven B Coffey; Leanne Buzon; Martha L Minich; Kenneth J Dirico; Susan Tapley; R Kirk McPherson; Eliot Sugarman; H James Harwood; William Esler
Discovery of small molecule isozyme non-specific inhibitors of mammalian acetyl-CoA carboxylase 1 and 2.
J W Corbett; K Dirico; W Song; Brian P Boscoe; Shawn D Doran; D Boyer; Xiayang Qiu; Mark J Ammirati; Maria A Vanvolkenburg; R Kirk McPherson; Janice C Parker; Eric D Cox
Design and synthesis of potent amido- and benzyl-substituted cis-3-amino-4-(2-cyanopyrrolidide)pyrrolidinyl DPP-IV inhibitors.
Stephen W Wright; Mark J Ammirati; Kim M Andrews; Anne M Brodeur; dennis danley; Shawn D Doran; Jay S Lillquist; Shenping Liu; Lester D McClure; R Kirk McPherson; Thanh V Olson; Stephen J Orena; Janice C Parker; Benjamin N Rocke; Walter Soeller; Carolyn B Soglia; Judith L Treadway; Maria A Vanvolkenburg; Zhengrong Zhao; Eric D Cox
(3R,4S)-4-(2,4,5-Trifluorophenyl)-pyrrolidin-3-ylamine inhibitors of dipeptidyl peptidase IV: synthesis, in vitro, in vivo, and X-ray crystallographic characterization.

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All Publications

2010: Jeffrey W Corbett; Kevin D Freeman-Cook; Richard Elliott; Felix Vajdos; Francis Rajamohan; Darcy Kohls; Eric Marr; Hailong Zhang; Liang Tong; Meihua Tu; Sharad Murdande; Shawn D Doran; Janet A Houser; Wei Song; Christopher J Jones; Steven B Coffey; Leanne Buzon; Martha L Minich; Kenneth J Dirico; Susan Tapley; R Kirk McPherson; Eliot Sugarman; H James Harwood; William Esler
Discovery of small molecule isozyme non-specific inhibitors of mammalian acetyl-CoA carboxylase 1 and 2.
Bioorganic & medicinal chemistry letters 2010;20(7):2383-8.
2007: J W Corbett; K Dirico; W Song; Brian P Boscoe; Shawn D Doran; D Boyer; Xiayang Qiu; Mark J Ammirati; Maria A Vanvolkenburg; R Kirk McPherson; Janice C Parker; Eric D Cox
Design and synthesis of potent amido- and benzyl-substituted cis-3-amino-4-(2-cyanopyrrolidide)pyrrolidinyl DPP-IV inhibitors.
Bioorganic & medicinal chemistry letters 2007;17(24):6707-13.
2007: Stephen W Wright; Mark J Ammirati; Kim M Andrews; Anne M Brodeur; dennis danley; Shawn D Doran; Jay S Lillquist; Shenping Liu; Lester D McClure; R Kirk McPherson; Thanh V Olson; Stephen J Orena; Janice C Parker; Benjamin N Rocke; Walter Soeller; Carolyn B Soglia; Judith L Treadway; Maria A Vanvolkenburg; Zhengrong Zhao; Eric D Cox
(3R,4S)-4-(2,4,5-Trifluorophenyl)-pyrrolidin-3-ylamine inhibitors of dipeptidyl peptidase IV: synthesis, in vitro, in vivo, and X-ray crystallographic characterization.
Bioorganic & medicinal chemistry letters 2007;17(20):5638-42.
2006: Stephen W Wright; Mark J Ammirati; Kim M Andrews; Anne M Brodeur; dennis danley; Shawn D Doran; Jay S Lillquist; Lester D McClure; R Kirk McPherson; Stephen J Orena; Janice C Parker; Jana Polivkova; Xiayang Qiu; Walter Soeller; Carolyn B Soglia; Judith L Treadway; Maria A Vanvolkenburg; Hong Wang; Donald C Wilder; Thanh V Olson
cis-2,5-dicyanopyrrolidine inhibitors of dipeptidyl peptidase IV: synthesis and in vitro, in vivo, and X-ray crystallographic characterization.
Journal of medicinal chemistry 2006;49(11):3068-76.
2006: Li J Yu; Yue Chen; Judith L Treadway; R Kirk McPherson; Scott C McCoid; E Michael Gibbs; Dennis J Hoover
Establishment of correlation between in vitro enzyme binding potency and in vivo pharmacological activity: application to liver glycogen phosphorylase a inhibitors.
The Journal of pharmacology and experimental therapeutics 2006;317(3):1230-7.
2005: Stephen W Wright; Virginia L Rath; Paul E Genereux; David L Hageman; Carolyn B Levy; Lester D McClure; Scott C McCoid; R Kirk McPherson; Teresa M Schelhorn; Donald E Wilder; William J Zavadoski; E Michael Gibbs; Judith L Treadway
5-Chloroindoloyl glycine amide inhibitors of glycogen phosphorylase: synthesis, in vitro, in vivo, and X-ray crystallographic characterization.
Bioorganic & medicinal chemistry letters 2005;15(2):459-65.
2004: Ross Tracey; Judith L Treadway; William Magee; Jill C Sutt; R Kirk McPherson; Carolyn B Levy; Donald E Wilder; Li J Yu; Yue Chen; Ravi M Shanker; Alison K Mutchler; Andrew H Smith; David M Flynn; Delvin R Knight
Cardioprotective effects of ingliforib, a novel glycogen phosphorylase inhibitor.
American journal of physiology. Heart and circulatory physiology 2004;286(3):H1177-84.
2002: Stephen W Wright; Anthony A Carlo; Maynard D Carty; dennis danley; David L Hageman; George A Karam; Carolyn B Levy; Mahmoud N Mansour; Alan M Mathiowetz; Lester D McClure; Nestor B Nestor; R Kirk McPherson; Jayvardhan Pandit; Leslie R Pustilnik; Gayle K Schulte; Walter Soeller; Judith L Treadway; Ing-Kae Wang; Paul H Bauer
Anilinoquinazoline inhibitors of fructose 1,6-bisphosphatase bind at a novel allosteric site: synthesis, in vitro characterization, and X-ray crystallography.
Journal of medicinal chemistry 2002;45(18):3865-77.
2000: Janice C Parker; R Kirk McPherson; Kim M Andrews; Carolyn B Levy; J S Dubins; J E Chin; P V Perry; Bernard Hulin; D A Perry; T Inagaki; Koen A Dekker; K Tachikawa; Yutaka Sugie; Judith L Treadway
Effects of skyrin, a receptor-selective glucagon antagonist, in rat and human hepatocytes.
Diabetes 2000;49(12):2079-86.
2000: Virginia L Rath; Mark J Ammirati; dennis danley; Jennifer L Ekstrom; E Michael Gibbs; THOMAS HYNES; Alan M Mathiowetz; R Kirk McPherson; Thanh V Olson; Judith L Treadway; Dennis J Hoover
Human liver glycogen phosphorylase inhibitors bind at a new allosteric site.
Chemistry & biology 2000;7(9):677-82.
1998: Janice C Parker; Maria A Vanvolkenburg; Carolyn B Levy; William Martin; S H Burk; Younggil Kwon; C Giragossian; T G Gant; P A Carpino; R Kirk McPherson; P Vestergaard; Judith L Treadway
Plasma glucose levels are reduced in rats and mice treated with an inhibitor of glucose-6-phosphate translocase.
Diabetes 1998;47(10):1630-6.
1998: Dennis J Hoover; S Lefkowitz-Snow; J L Burgess-Henry; William Martin; Sandra J Armento; Ingrid A Stock; R Kirk McPherson; Paul E Genereux; E Michael Gibbs; Judith L Treadway
Indole-2-carboxamide inhibitors of human liver glycogen phosphorylase.
Journal of medicinal chemistry 1998;41(16):2934-8.
1998: William Martin; Dennis J Hoover; Sandra J Armento; Ingrid A Stock; R Kirk McPherson; dennis danley; R W Stevenson; E J Barrett; Judith L Treadway
Discovery of a human liver glycogen phosphorylase inhibitor that lowers blood glucose in vivo.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(4):1776-81.
1996: Ralph W Stevenson; R Kirk McPherson; L M Persson; Paul E Genereux; A G Swick; J Spitzer; J J Herbst; Kim M Andrews; D K Kreutter; E Michael Gibbs
The antihyperglycemic agent englitazone prevents the defect in glucose transport in rats fed a high-fat diet.
Diabetes 1996;45(1):60-6.
1994: Judith L Treadway; D M Hargrove; N A Nardone; R Kirk McPherson; J F Russo; Anthony J Milici; H A Stukenbrok; E Michael Gibbs; Ralph W Stevenson; Jeffrey Pessin
Enhanced peripheral glucose utilization in transgenic mice expressing the human GLUT4 gene.
The Journal of biological chemistry 1994;269(47):29956-61.
1993: M L Liu; E Michael Gibbs; S C McCoid; Anthony J Milici; H A Stukenbrok; R Kirk McPherson; Judith L Treadway; Jeffrey Pessin
Transgenic mice expressing the human GLUT4/muscle-fat facilitative glucose transporter protein exhibit efficient glycemic control.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(23):11346-50.
1993: Peter F Blackmore; R Kirk McPherson; Ralph W Stevenson
Actions of the novel antidiabetic agent englitazone in rat hepatocytes.
Metabolism: clinical and experimental 1993;42(12):1583-7.
1991: Ralph W Stevenson; R Kirk McPherson; Paul E Genereux; B H Danbury; D K Kreutter
Antidiabetic agent englitazone enhances insulin action in nondiabetic rats without producing hypoglycemia.
Metabolism: clinical and experimental 1991;40(12):1268-74.
1990: Ralph W Stevenson; N J Hutson; M N Krupp; R A Volkmann; G F Holland; J F Eggler; D A Clark; R Kirk McPherson; K L Hall; B H Danbury
Actions of novel antidiabetic agent englitazone in hyperglycemic hyperinsulinemic ob/ob mice.
Diabetes 1990;39(10):1218-27.