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Helen McShane

Research Profile

Chemicals & Drugs

Disorders

Tuberculosis

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Publications

TOP 3
A D White; A Williams; L Sibley; G Betts; M W Carroll; M J Dennis; N Edwards; K Gooch; P D Marsh; Helen McShane; Arturo Reyes-Sandoval; S A Sharpe
Evaluation of the Safety and Immunogenicity of a Candidate Tuberculosis Vaccine, MVA85A, Delivered by Aerosol to the Lungs of Macaques.
Joel Meyer; Helen McShane
The next 10 years for tuberculosis vaccines: do we have the right plans in place?
Michele Tameris; Linda van der Merwe; Robert Walker; J Bruce McClain; Helen McShane; Thomas J Scriba; Jacqui Shea; Marwou de Kock; Hennie Geldenhuys; Willem A Hanekom; Mark Hatherill; Gregory Hussey; Bernard Landry; Stephen Lockhart; Angelique K K Luabeya; Hassan Mahomed
Lessons learnt from the first efficacy trial of a new infant tuberculosis vaccine since BCG.

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All Publications

2013: A D White; A Williams; L Sibley; G Betts; M W Carroll; M J Dennis; N Edwards; K Gooch; P D Marsh; Helen McShane; Arturo Reyes-Sandoval; S A Sharpe
Evaluation of the Safety and Immunogenicity of a Candidate Tuberculosis Vaccine, MVA85A, Delivered by Aerosol to the Lungs of Macaques.
Clinical and vaccine immunology : CVI 2013;20(5):663-72.
2013: Joel Meyer; Helen McShane
The next 10 years for tuberculosis vaccines: do we have the right plans in place?
Expert review of vaccines 2013;12(4):443-51.
2013: Michele Tameris; Linda van der Merwe; Robert Walker; J Bruce McClain; Helen McShane; Thomas J Scriba; Jacqui Shea; Marwou de Kock; Hennie Geldenhuys; Willem A Hanekom; Mark Hatherill; Gregory Hussey; Bernard Landry; Stephen Lockhart; Angelique K K Luabeya; Hassan Mahomed
Lessons learnt from the first efficacy trial of a new infant tuberculosis vaccine since BCG.
Tuberculosis (Edinburgh, Scotland) 2013;93(2):143-9.
2013: Roxana Rustomjee; S Self; J Shea; G Steel; A M Ginsberg; W Hanekom; S Lockhart; Hassan Mahomed; B McClain; R McLeod; Helen McShane; M J Brennan; C M Chetty-Makkan; G J Churchyard
Designing an adaptive phase II/III trial to evaluate efficacy, safety and immune correlates of new TB vaccines in young adults and adolescents.
Tuberculosis (Edinburgh, Scotland) 2013;93(2):136-42.
2013: Joel Meyer; Ian D Poulton; Hazel C Poyntz; Rosalind Rowland; Iman Satti; Rachel Tanner; Helen A Fletcher; Kristin L Griffiths; Stephanie A Harris; Helen McShane
Comparing the safety and immunogenicity of a candidate TB vaccine MVA85A administered by intramuscular and intradermal delivery.
Vaccine 2013;31(7):1026-33.
2013: Rosalind Rowland; Iman Satti; Janet T Scott; Megan Whittaker; Nicola Williams; Joel Meyer; Angela M Minassian; Geraldine A O'Hara; Ansar A Pathan; Ian D Poulton; Hazel C Poyntz; Cynthia Bateman; Sarah C Gilbert; Matthew Hamill; Stephanie A Harris; Adrian V S Hill; Alison M Lawrie; Magali M L Matsumiya; Helen McShane
Safety and immunogenicity of an FP9-vectored candidate tuberculosis vaccine (FP85A), alone and with candidate vaccine MVA85A in BCG-vaccinated healthy adults: a phase I clinical trial.
Human vaccines & immunotherapeutics 2013;9(1):50-62.
2012: Ansar A Pathan; David W Porter; Ian D Poulton; Rosalind Rowland; Clare R Sander; Helen A Fletcher; Adrian V S Hill; Angela M Minassian; Helen McShane
Effect of vaccine dose on the safety and immunogenicity of a candidate TB vaccine, MVA85A, in BCG vaccinated UK adults.
Vaccine 2012;30(38):5616-24.
2012: A A Odutola; Patrick K Owiafe; O A Owolabi; Helen McShane; M O C Ota
A new TB vaccine, MVA85A, induces durable antigen-specific responses 14 months after vaccination in African infants.
Vaccine 2012;30(38):5591-4.
2012: Christopher J A Duncan; Sarah C Gilbert; Matthew Hamill; Patrick J Lillie; Helen McShane; Joel Meyer; Geraldine A O'Hara; Ian D Poulton; Rosalind Rowland; Susanne H Sheehy; Laura Dinsmore; Hannah Donaldson; Adrian V S Hill
Incidental diagnosis in healthy clinical trial subjects.
Clinical and translational science 2012;5(4):348-50.
2012: Helen McShane; Steven G Reed; Ann Williams; Marcel Behr; Paul E Fine; William R Jacobs; David N McMurray; Ian M Orme
BCG: myths, realities, and the need for alternative vaccine strategies.
Tuberculosis (Edinburgh, Scotland) 2012;92(3):283-8.
2012: Angela M Minassian; Ian D Poulton; Iman Satti; Adrian V S Hill; Joel Meyer; Helen McShane
A human challenge model for Mycobacterium tuberculosis using Mycobacterium bovis bacille Calmette-Guerin.
The Journal of infectious diseases 2012;205(7):1035-42.
2012: Thomas J Scriba; Erica Smit; Michele Tameris; Linda van der Merwe; Ashley Veldsman; Lebohang Makhethe; Katya Mauff; Helen McShane; Sizulu Moyo; Humphrey Mulenga; Nathaniel Brittain; Marwou de Kock; Hendrik Geldenhuys; Sebastian Gelderbloem; Willem A Hanekom; Mark Hatherill; Anthony Hawkridge; Adrian V S Hill; Elizabeth J Hughes; Gregory D Hussey; Esme Janse van Rensburg; Blessing Kadira; Alison Lawrie; Hassan Mahomed
A phase IIa trial of the new tuberculosis vaccine, MVA85A, in HIV- and/or Mycobacterium tuberculosis-infected adults.
American journal of respiratory and critical care medicine 2012;185(7):769-78.
2012: Gareth Betts; Matthew G Cottingham; Adrian Hill; Hazel Poyntz; Arturo Reyes-Sandoval; Elena Stylianou; Helen McShane
Optimising immunogenicity with viral vectors: mixing MVA and HAdV-5 expressing the mycobacterial antigen Ag85A in a single injection.
PloS one 2012;7(12):e50447.
2011: Helen McShane
Tuberculosis vaccines: beyond bacille Calmette-Guerin.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 2011;366(1579):2782-9.
2011: Helen McShane; Ann Williams
Tuberculosis vaccine promises sterilizing immunity.
Nature medicine 2011;17(10):1185-6.
2011: Anna M Checkley; Helen McShane
Tuberculosis vaccines: progress and challenges.
Trends in pharmacological sciences 2011;32(10):601-6.
2011: Martin O C Ota; Patrick K Owiafe; Olumuyiwa A Owolabi; Sarah Rowland-Jones; Nicola Williams; Richard A Adegbola; Nathaniel J Brittain; Simon A Donkor; Adrian V S Hill; Aderonke A Odutola; Helen McShane
Immunogenicity of the tuberculosis vaccine MVA85A is reduced by coadministration with EPI vaccines in a randomized controlled trial in Gambian infants.
Science translational medicine 2011;3(88):88ra56.
2011: Rosalind Rowland; Helen McShane
Tuberculosis vaccines in clinical trials.
Expert review of vaccines 2011;10(5):645-58.
2011: Angela M Minassian; Ansar A Pathan; Ian D Poulton; Hazel Poyntz; David A Price; Mario Roederer; Guy Rooney; Jonathan Ross; Rosalind Rowland; Clare R Sander; Iman Satti; Jackie Sherrard; Nicola Williams; Alan Winston; David R Ambrozak; Natalie E R Beveridge; Joseph P Casazza; Daniel C Douek; Helen A Fletcher; Kristin Griffiths; Matthew Hamill; Stephanie Harris; Brenna J Hill; Richard A Koup; Alison M Lawrie; Helen McShane
A Phase I study evaluating the safety and immunogenicity of MVA85A, a candidate TB vaccine, in HIV-infected adults.
BMJ open 2011;1(2):e000223.
2011: Anna M Checkley; Tanya Golubchik; Willem A Hanekom; Adrian V S Hill; Thomas J Scriba; David H Wyllie; Helen McShane
Identification of antigens specific to non-tuberculous mycobacteria: the Mce family of proteins as a target of T cell immune responses.
PloS one 2011;6(10):e26434.
2011: Kristin L Griffiths; Adrian V S Hill; Natalie E R Beveridge; Helen A Fletcher; Angela M Minassian; Ansar A Pathan; Clare R Sander; Helen McShane
Th1/Th17 cell induction and corresponding reduction in ATP consumption following vaccination with the novel Mycobacterium tuberculosis vaccine MVA85A.
PloS one 2011;6(8):e23463.
2011: Angela M Minassian; Edward O Ronan; Hazel Poyntz; Adrian V S Hill; Helen McShane
Preclinical development of an in vivo BCG challenge model for testing candidate TB vaccine efficacy.
PloS one 2011;6(5):e19840.
2011: Richard Hopkins; Anne Bridgeman; Joan Joseph; Sarah C Gilbert; Helen McShane; Tomáš Hanke
Dual neonate vaccine platform against HIV-1 and M. tuberculosis.
PloS one 2011;6(5):e20067.
2010: Simone C de Cassan; Ansar A Pathan; Clare R Sander; Angela Minassian; Rosalind Rowland; Adrian V S Hill; Helen McShane; Helen A Fletcher
Investigating the induction of vaccine-induced Th17 and regulatory T cells in healthy, Mycobacterium bovis BCG-immunized adults vaccinated with a new tuberculosis vaccine, MVA85A.
Clinical and vaccine immunology : CVI 2010;17(7):1066-73.
2009: Clare R Sander; Ansar A Pathan; Natalie E R Beveridge; Ian Poulton; Angela Minassian; Nicola Alder; Johan Van Wijgerden; Adrian V S Hill; Fergus V Gleeson; Robert J O Davies; Geoffrey Pasvol; Helen McShane
Safety and immunogenicity of a new tuberculosis vaccine, MVA85A, in Mycobacterium tuberculosis-infected individuals.
American journal of respiratory and critical care medicine 2009;179(8):724-33.
2009: Helen McShane
Vaccine strategies against tuberculosis.
Swiss medical weekly 2009;139(11-12):156-60.
2009: Elma Z Tchilian; Christiane Desel; Emily K Forbes; Silke Bandermann; Clare R Sander; Adrian V S Hill; Helen McShane; Stefan H E Kaufmann
Immunogenicity and protective efficacy of prime-boost regimens with recombinant (delta)ureC hly+ Mycobacterium bovis BCG and modified vaccinia virus ankara expressing M. tuberculosis antigen 85A against murine tuberculosis.
Infection and immunity 2009;77(2):622-31.
2008: Angela M Minassian; Helen McShane
Tuberculosis vaccines: present and future.
Expert review of respiratory medicine 2008;2(6):721-38.
2008: Natalie E R Beveridge; Helen A Fletcher; Jane Hughes; Ansar A Pathan; Thomas J Scriba; Angela Minassian; Clare R Sander; Kathryn T Whelan; Hazel M Dockrell; Adrian V S Hill; Willem A Hanekom; Helen McShane
A comparison of IFNgamma detection methods used in tuberculosis vaccine trials.
Tuberculosis (Edinburgh, Scotland) 2008;88(6):631-40.
2008: Emily K Forbes; Clare Sander; Edward O Ronan; Helen McShane; Adrian V S Hill; Peter C L Beverley; Elma Z Tchilian
Multifunctional, high-level cytokine-producing Th1 cells in the lung, but not spleen, correlate with protection against Mycobacterium tuberculosis aerosol challenge in mice.
Journal of immunology (Baltimore, Md. : 1950) 2008;181(7):4955-64.
2008: Helen A Fletcher; Ansar A Pathan; Tamara K Berthoud; Susanna Dunachie; Kathryn T Whelan; Nicola C Alder; Clare R Sander; Adrian V S Hill; Helen McShane
Boosting BCG vaccination with MVA85A down-regulates the immunoregulatory cytokine TGF-beta1.
Vaccine 2008;26(41):5269-75.
2008: Roger H Brookes; Philip C Hill; Patrick K Owiafe; Hannah B Ibanga; David J Jeffries; Simon A Donkor; Helen A Fletcher; Abdulrahman Hammond; Christian Lienhardt; Richard A Adegbola; Helen McShane; Adrian V S Hill
Safety and immunogenicity of the candidate tuberculosis vaccine MVA85A in West Africa.
PloS one 2008;3(8):e2921.
2007: Martin O C Ota; Roger H Brookes; Philip C Hill; Patrick K Owiafe; Hannah B Ibanga; Simon A Donkor; Timothy Awine; Helen McShane; Richard A Adegbola
The effect of tuberculin skin test and BCG vaccination on the expansion of PPD-specific IFN-gamma producing cells ex vivo.
Vaccine 2007;25(52):8861-7.
2007: Natalie E R Beveridge; David A Price; Joseph P Casazza; Ansar A Pathan; Clare R Sander; Tedi E Asher; David R Ambrozak; Melissa L Precopio; Phillip Scheinberg; Nicola C Alder; Mario Roederer; Richard A Koup; Daniel C Douek; Adrian V S Hill; Helen McShane
Immunisation with BCG and recombinant MVA85A induces long-lasting, polyfunctional Mycobacterium tuberculosis-specific CD4+ memory T lymphocyte populations.
European journal of immunology 2007;37(11):3089-100.
2007: Eung-Jun Im; Narcis Saubi; Goretti Virgili; Clare Sander; Denise Teoh; José M Gatell; Helen McShane; Joan Joseph; Tomás Hanke
Vaccine platform for prevention of tuberculosis and mother-to-child transmission of human immunodeficiency virus type 1 through breastfeeding.
Journal of virology 2007;81(17):9408-18.
2007: C Sander; Helen McShane
Translational mini-review series on vaccines: Development and evaluation of improved vaccines against tuberculosis.
Clinical and experimental immunology 2007;147(3):401-11.
2007: Ansar A Pathan; Clare R Sander; Helen A Fletcher; Ian Poulton; Nicola C Alder; Natalie E R Beveridge; Kathryn T Whelan; Adrian V S Hill; Helen McShane
Boosting BCG with recombinant modified vaccinia ankara expressing antigen 85A: different boosting intervals and implications for efficacy trials.
PloS one 2007;2(10):e1052.
2006: Hannah B Ibanga; Roger H Brookes; Philip C Hill; Patrick K Owiafe; Helen A Fletcher; Christian Lienhardt; Adrian V S Hill; Richard A Adegbola; Helen McShane
Early clinical trials with a new tuberculosis vaccine, MVA85A, in tuberculosis-endemic countries: issues in study design.
The Lancet infectious diseases 2006;6(8):522-8.
2006: Sarah Gilbert; Vasee S Moorthy; Laura Andrews; Ansar A Pathan; Samuel J McConkey; Jenni M Vuola; Sheila Keating; Tamara Berthoud; Daniel Webster; Helen McShane; Adrian V S Hill
Synergistic DNA-MVA prime-boost vaccination regimes for malaria and tuberculosis.
Vaccine 2006;24(21):4554-61.
2006: Helen Fletcher; Helen McShane
Tuberculosis vaccines: current status and future prospects.
Expert opinion on emerging drugs 2006;11(2):207-15.
2006: Rebecca Sutherland; Hongbing Yang; Thomas J Scriba; Beatrice Ondondo; Nicola Robinson; Christopher Conlon; Annie Suttill; Helen McShane; Sarah Fidler; Andrew McMichael; Lucy Dorrell
Impaired IFN-gamma-secreting capacity in mycobacterial antigen-specific CD4 T cells during chronic HIV-1 infection despite long-term HAART.
AIDS (London, England) 2006;20(6):821-9.
2006: Inese Cebere; Lucy Dorrell; Helen McShane; Alison Simmons; Sheena McCormack; Claudia Schmidt; Carol Smith; Mary Brooks; Joanna E Roberts; Simon C Darwin; Patricia E Fast; Christopher Conlon; Sarah Rowland-Jones; Andrew J McMichael; Tomás Hanke
Phase I clinical trial safety of DNA- and modified virus Ankara-vectored human immunodeficiency virus type 1 (HIV-1) vaccines administered alone and in a prime-boost regime to healthy HIV-1-uninfected volunteers.
Vaccine 2006;24(4):417-25.
2005: A Williams; Nilu Goonetilleke; Helen McShane; Simon O Clark; Graham Hatch; Sarah Gilbert; Adrian V S Hill
Boosting with poxviruses enhances Mycobacterium bovis BCG efficacy against tuberculosis in guinea pigs.
Infection and immunity 2005;73(6):3814-6.
2005: Helen McShane; Adrian Hill
Prime-boost immunisation strategies for tuberculosis.
Microbes and infection / Institut Pasteur 2005;7(5-6):962-7.
2005: Helen McShane; Ansar A Pathan; Clare R Sander; Nilu Goonetilleke; Helen A Fletcher; Adrian V S Hill
Boosting BCG with MVA85A: the first candidate subunit vaccine for tuberculosis in clinical trials.
Tuberculosis (Edinburgh, Scotland) 2005;85(1-2):47-52.
2004: Helen McShane; Ansar A Pathan; Clare R Sander; Sheila Keating; Sarah Gilbert; Kris Huygen; Helen A Fletcher; Adrian V S Hill
Recombinant modified vaccinia virus Ankara expressing antigen 85A boosts BCG-primed and naturally acquired antimycobacterial immunity in humans.
Nature medicine 2004;10(11):1240-4.
2004: Paul T-Y Ayuk; S Dudley; Helen McShane; M Rees; Ian Z Mackenzie
Efficacy of follow-up and contact tracing of women who test positive for genital tract chlamydia trachomatis prior to pregnancy termination.
Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology 2004;24(6):687-9.
2004: Helen McShane
Developing an improved vaccine against tuberculosis.
Expert review of vaccines 2004;3(3):299-306.
2004: Matilu Mwau; Inese Cebere; Julian Sutton; Priscilla Chikoti; Nicola Winstone; Edmund G-T Wee; Tara Beattie; Yun-Hsiang Chen; Lucy Dorrell; Helen McShane; Claudia Schmidt; Mary Brooks; Sandip Patel; Joanna Roberts; Christopher Conlon; Sarah L Rowland-Jones; Job J Bwayo; Andrew J McMichael; Tomás Hanke
A human immunodeficiency virus 1 (HIV-1) clade A vaccine in clinical trials: stimulation of HIV-specific T-cell responses by DNA and recombinant modified vaccinia virus Ankara (MVA) vaccines in humans.
The Journal of general virology 2004;85(Pt 4):911-9.
2003: Roger H Brookes; Ansar A Pathan; Helen McShane; Meike Hensmann; David A Price; Adrian V S Hill
CD8+ T cell-mediated suppression of intracellular Mycobacterium tuberculosis growth in activated human macrophages.
European journal of immunology 2003;33(12):3293-302.
2003: Nilu Goonetilleke; Helen McShane; Carolyn M Hannan; Richard J Anderson; Roger H Brookes; Adrian V S Hill
Enhanced immunogenicity and protective efficacy against Mycobacterium tuberculosis of bacille Calmette-Guérin vaccine using mucosal administration and boosting with a recombinant modified vaccinia virus Ankara.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(3):1602-9.
2003: Helen McShane
Susceptibility to tuberculosis--the importance of the pathogen as well as the host.
Clinical and experimental immunology 2003;133(1):20-1.
2002: Helen McShane; Shahriar Behboudi; Nilu Goonetilleke; Roger H Brookes; Adrian V S Hill
Protective immunity against Mycobacterium tuberculosis induced by dendritic cells pulsed with both CD8(+)- and CD4(+)-T-cell epitopes from antigen 85A.
Infection and immunity 2002;70(3):1623-6.
2002: Helen McShane
Prime-boost immunization strategies for infectious diseases.
Current opinion in molecular therapeutics 2002;4(1):23-7.
2001: Ansar A Pathan; Katalin A Wilkinson; Paul Klenerman; Helen McShane; Robert N Davidson; Geoffrey Pasvol; Adrian V S Hill; Ajit Lalvani
Direct ex vivo analysis of antigen-specific IFN-gamma-secreting CD4 T cells in Mycobacterium tuberculosis-infected individuals: associations with clinical disease state and effect of treatment.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(9):5217-25.
2001: Ajit Lalvani; Ansar A Pathan; Helen McShane; Robert J Wilkinson; M Latif; Christopher Conlon; Geoffrey Pasvol; Adrian V S Hill
Rapid detection of Mycobacterium tuberculosis infection by enumeration of antigen-specific T cells.
American journal of respiratory and critical care medicine 2001;163(4):824-8.
2001: Helen McShane; Roger H Brookes; Sarah Gilbert; Adrian V S Hill
Enhanced immunogenicity of CD4(+) t-cell responses and protective efficacy of a DNA-modified vaccinia virus Ankara prime-boost vaccination regimen for murine tuberculosis.
Infection and immunity 2001;69(2):681-6.
2000: Ansar A Pathan; Katalin A Wilkinson; Robert J Wilkinson; M Latif; Helen McShane; G Pasvol; Adrian V S Hill; A Lalvani
High frequencies of circulating IFN-gamma-secreting CD8 cytotoxic T cells specific for a novel MHC class I-restricted Mycobacterium tuberculosis epitope in M. tuberculosis-infected subjects without disease.
European journal of immunology 2000;30(9):2713-21.
1998: Helen McShane; C M Tang; C P Conlon
Disseminated Penicillium marneffei infection presenting as a right upper lobe mass in an HIV positive patient.
Thorax 1998;53(10):905-6.