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John McVey

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Margaret R Duffy; John H McVey; Alan L Parker; Angela C Bradshaw; Andrew H Baker
A cluster of basic amino acids in the factor X serine protease mediates surface attachment of adenovirus/FX complexes.
Raul Alba; Angela C Bradshaw; Lynda Coughlan; Laura Denby; Robert A McDonald; Simon Waddington; Suzanne M K Buckley; Jenny A Greig; Alan L Parker; Ashley M Miller; Hongjie Wang; André Lieber; Nico van Rooijen; John H McVey; Stuart A Nicklin; Andrew H Baker
Biodistribution and retargeting of FX-binding ablated adenovirus serotype 5 vectors.
Jenny A Greig; Suzanne Mk Buckley; Simon Waddington; Alan L Parker; David Bhella; Rebecca Pink; Ahad A Rahim; Takashi Morita; Stuart A Nicklin; John H McVey; Andrew H Baker
Influence of coagulation factor x on in vitro and in vivo gene delivery by adenovirus (Ad) 5, Ad35, and chimeric Ad5/Ad35 vectors.

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All Publications

2011: Margaret R Duffy; John H McVey; Alan L Parker; Angela C Bradshaw; Andrew H Baker
A cluster of basic amino acids in the factor X serine protease mediates surface attachment of adenovirus/FX complexes.
Journal of virology 2011;85(20):10914-9.
2010: Raul Alba; Angela C Bradshaw; Lynda Coughlan; Laura Denby; Robert A McDonald; Simon Waddington; Suzanne M K Buckley; Jenny A Greig; Alan L Parker; Ashley M Miller; Hongjie Wang; André Lieber; Nico van Rooijen; John H McVey; Stuart A Nicklin; Andrew H Baker
Biodistribution and retargeting of FX-binding ablated adenovirus serotype 5 vectors.
Blood 2010;116(15):2656-64.
2009: Jenny A Greig; Suzanne Mk Buckley; Simon Waddington; Alan L Parker; David Bhella; Rebecca Pink; Ahad A Rahim; Takashi Morita; Stuart A Nicklin; John H McVey; Andrew H Baker
Influence of coagulation factor x on in vitro and in vivo gene delivery by adenovirus (Ad) 5, Ad35, and chimeric Ad5/Ad35 vectors.
Molecular therapy : the journal of the American Society of Gene Therapy 2009;17(10):1683-91.
2009: Raul Alba; Angela C Bradshaw; Alan L Parker; David Bhella; Simon Waddington; Stuart A Nicklin; Nico van Rooijen; Jerome Custers; Jaap Goudsmit; Dan H Barouch; John H McVey; Andrew H Baker
Identification of coagulation factor (F)X binding sites on the adenovirus serotype 5 hexon: effect of mutagenesis on FX interactions and gene transfer.
Blood 2009;114(5):965-71.
2009: Alan L Parker; Simon Waddington; Suzanne Buckley; Jerome Custers; Menzo J E Havenga; Nico van Rooijen; Jaap Goudsmit; John H McVey; Stuart A Nicklin; Andrew H Baker
Effect of neutralizing sera on factor x-mediated adenovirus serotype 5 gene transfer.
Journal of virology 2009;83(1):479-83.
2008: Hongjie Wang; Ying Liu; Zongyi Li; Sebastian Tuve; Daniel Stone; Oleksandr Kalyushniy; Dmitry M Shayakhmetov; Christophe Verlinde; Thilo Stehle; John H McVey; Andrew Baker; Kah-Whye Peng; Steve R Roffler; André Lieber
In vitro and in vivo properties of adenovirus vectors with increased affinity to CD46.
Journal of virology 2008;82(21):10567-79.
2008: Chih-Che Lin; Daxin Chen; John H McVey; David K C Cooper; Anthony Dorling
Expression of tissue factor and initiation of clotting by human platelets and monocytes after incubation with porcine endothelial cells.
Transplantation 2008;86(5):702-9.
2008: Daxin Chen; Adam Carpenter; Joel Abrahams; Rachel C Chambers; Robert I Lechler; John H McVey; Anthony Dorling
Protease-activated receptor 1 activation is necessary for monocyte chemoattractant protein 1-dependent leukocyte recruitment in vivo.
The Journal of experimental medicine 2008;205(8):1739-46.
2008: Daxin Chen; Joel M Abrahams; Leanne M Smith; John H McVey; Robert I Lechler; Anthony Dorling
Regenerative repair after endoluminal injury in mice with specific antagonism of protease activated receptors on CD34+ vascular progenitors.
Blood 2008;111(8):4155-64.
2008: Simon Waddington; John H McVey; David Bhella; Alan L Parker; Kristeen Barker; Hideko Atoda; Rebecca Pink; Suzanne Buckley; Jenny A Greig; Laura Denby; Jerome Custers; Takashi Morita; Ivo M B Francischetti; Robson Q Monteiro; Dan H Barouch; Nico van Rooijen; Claudio Napoli; Menzo J E Havenga; Stuart A Nicklin; Andrew H Baker
Adenovirus serotype 5 hexon mediates liver gene transfer.
Cell 2008;132(3):397-409.
2007: Simon Waddington; Alan L Parker; Menzo J E Havenga; Stuart A Nicklin; Suzanne Buckley; John H McVey; Andrew H Baker
Targeting of adenovirus serotype 5 (Ad5) and 5/47 pseudotyped vectors in vivo: fundamental involvement of coagulation factors and redundancy of CAR binding by Ad5.
Journal of virology 2007;81(17):9568-71.
2007: Laura Denby; Lorraine M Work; Dan J Von Seggern; Eugene Wu; John H McVey; Stuart A Nicklin; Andrew H Baker
Development of renal-targeted vectors through combined in vivo phage display and capsid engineering of adenoviral fibers from serotype 19p.
Molecular therapy : the journal of the American Society of Gene Therapy 2007;15(9):1647-54.
2007: Andrew H Baker; John H McVey; Simon Waddington; Nelson C Di Paolo; Dmitry M Shayakhmetov
The influence of blood on in vivo adenovirus bio-distribution and transduction.
Molecular therapy : the journal of the American Society of Gene Therapy 2007;15(8):1410-6.
2007: Alan L Parker; John H McVey; Jessica H Doctor; Oscar Lopez-Franco; Simon Waddington; Menzo J E Havenga; Stuart A Nicklin; Andrew H Baker
Influence of coagulation factor zymogens on the infectivity of adenoviruses pseudotyped with fibers from subgroup D.
Journal of virology 2007;81(7):3627-31.
2007: Angelika B Kritz; Campbell G Nicol; Kate L Dishart; Ruth Nelson; Susan Holbeck; Dan J Von Seggern; Lorraine M Work; John H McVey; Stuart A Nicklin; Andrew H Baker
Adenovirus 5 fibers mutated at the putative HSPG-binding site show restricted retargeting with targeting peptides in the HI loop.
Molecular therapy : the journal of the American Society of Gene Therapy 2007;15(4):741-9.
2007: S Shrivastava; John H McVey; Anthony Dorling
The interface between coagulation and immunity.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2007;7(3):499-506.
2007: Paula H B Bolton-Maggs; Charles R M Hay; Doreen Shanks; Michael J Mitchell; John H McVey
The importance of tissue factor source in the management of Factor VII deficiency.
Thrombosis and haemostasis 2007;97(1):151-2.
2006: Alan L Parker; Simon Waddington; Campbell G Nicol; Dmitry M Shayakhmetov; Suzanne Buckley; Laura Denby; Geoffrey Kemball-Cook; Shaoheng Ni; André Lieber; John H McVey; Stuart A Nicklin; Andrew H Baker
Multiple vitamin K-dependent coagulation zymogens promote adenovirus-mediated gene delivery to hepatocytes.
Blood 2006;108(8):2554-61.
2006: Daxin Chen; M Weber; P G Shiels; R Dong; Zoe Webster; John H McVey; Geoffrey Kemball-Cook; Edward G D Tuddenham; R I Lechler; Anthony Dorling
Postinjury vascular intimal hyperplasia in mice is completely inhibited by CD34+ bone marrow-derived progenitor cells expressing membrane-tethered anticoagulant fusion proteins.
Journal of thrombosis and haemostasis : JTH 2006;4(10):2191-8.
2006: Keith Gomez; John H McVey
Tissue factor initiated blood coagulation.
Frontiers in bioscience : a journal and virtual library 2006;11():1349-59.
2005: Keith Gomez; John H McVey; Edward G D Tuddenham
Inhibition of coagulation by macromolecular complexes.
Haematologica 2005;90(11):1570-6.
2005: Christiane Albrecht; John H McVey; James I Elliott; Alessandro Sardini; Ildiko Kasza; Andrew D Mumford; Rossi P Naoumova; Edward G D Tuddenham; Katalin Szabo; Christopher F Higgins
A novel missense mutation in ABCA1 results in altered protein trafficking and reduced phosphatidylserine translocation in a patient with Scott syndrome.
Blood 2005;106(2):542-9.
2005: John H McVey; Kalpana Lal; Yasufumi Imanaka; Geoffrey Kemball-Cook; Paula H B Bolton-Maggs; Edward G D Tuddenham
Characterisation of blood coagulation factor XI T475I.
Thrombosis and haemostasis 2005;93(6):1082-8.
2005: James I Elliott; John H McVey; Christopher F Higgins
The P2X7 receptor is a candidate product of murine and human lupus susceptibility loci: a hypothesis and comparison of murine allelic products.
Arthritis research & therapy 2005;7(3):R468-75.
2005: Andrew D Mumford; Daxin Chen; Anthony Dorling; Geoffrey Kemball-Cook; John H McVey
Generation of a polyclonal rabbit anti-mouse tissue factor antibody by nucleic acid immunisation.
Thrombosis and haemostasis 2005;93(1):160-4.
2004: Daxin Chen; Michele Weber; John H McVey; Geoffrey Kemball-Cook; Edward G D Tuddenham; Robert I Lechler; Anthony Dorling
Complete inhibition of acute humoral rejection using regulated expression of membrane-tethered anticoagulants on xenograft endothelium.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2004;4(12):1958-63.
2004: Katalin Takács; Camille Du Roure; Stephen Nabarro; Niall Dillon; John H McVey; Zoe Webster; Angus Macneil; István Bartók; Christopher Higgins; David Gray; Matthias Merkenschlager; Amanda G Fisher
The regulated long-term delivery of therapeutic proteins by using antigen-specific B lymphocytes.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(46):16298-303.
2004: Daxin Chen; Konstantinos Giannopoulos; Paul G Shiels; Zoe Webster; John H McVey; Geoffrey Kemball-Cook; Edward G D Tuddenham; Marilyn Moore; Robert Lechler; Anthony Dorling
Inhibition of intravascular thrombosis in murine endotoxemia by targeted expression of hirudin and tissue factor pathway inhibitor analogs to activated endothelium.
Blood 2004;104(5):1344-9.
2004: Keith Gomez; Michael A Laffan; Geoffrey Kemball-Cook; John Pasi; Mark Layton; Jack D Singer; Edward G D Tuddenham; John H McVey
Two novel mutations in severe factor VII deficiency.
British journal of haematology 2004;126(1):105-10.
2004: Mårten Steen; Eva A Norstrøm; Ann-Louise Tholander; Paula H B Bolton-Maggs; Andrew D Mumford; John H McVey; Edward G D Tuddenham; Björn Dahlbäck
Functional characterization of factor V-Ile359Thr: a novel mutation associated with thrombosis.
Blood 2004;103(9):3381-7.
2004: James I Elliott; Andrew D Mumford; Christiane Albrecht; Peter W Collins; John C Giddings; Christopher F Higgins; Edward G D Tuddenham; John H McVey
Characterisation of lymphocyte responses to Ca2+ in Scott syndrome.
Thrombosis and haemostasis 2004;91(2):412-5.
2004: Andrew D Mumford; John H McVey
Tissue factor in the myocardium: evidence of roles in haemostasis and inflammation.
Disease markers 2004;20(6):353-8.
2003: Andrew D Mumford; John H McVey; Colin Morse; Keith Gomez; Mårten Steen; E A Norstrom; Edward G D Tuddenham; B Dahlback; Paula H B Bolton-Maggs
Factor V I359T: a novel mutation associated with thrombosis and resistance to activated protein C.
British journal of haematology 2003;123(3):496-501.
2003: E B Bachli; C M Pech; K M Johnson; D J D Johnson; Edward G D Tuddenham; John H McVey
Factor Xa and thrombin, but not factor VIIa, elicit specific cellular responses in dermal fibroblasts.
Journal of thrombosis and haemostasis : JTH 2003;1(9):1935-44.
2003: C J Davidson; Edward G D Tuddenham; John H McVey
450 million years of hemostasis.
Journal of thrombosis and haemostasis : JTH 2003;1(7):1487-94.
2003: John H McVey
Your bleeding heart: lessons from low tissue factor expression in mice.
Trends in pharmacological sciences 2003;24(6):269-72.
2003: Colin J Davidson; Robert Hirt; Kalpana Lal; Philip Snell; greg elgar; Edward G D Tuddenham; John H McVey
Molecular evolution of the vertebrate blood coagulation network.
Thrombosis and haemostasis 2003;89(3):420-8.
2003: Dezsö David; I M A Santos; K Johnson; Edward G D Tuddenham; John H McVey
Analysis of the consequences of premature termination codons within factor VIII coding sequences.
Journal of thrombosis and haemostasis : JTH 2003;1(1):139-46.
2002: Andrew D Mumford; Michael A Laffan; James O'Donnell; John H McVey; Daniel J D Johnson; Richard A Manning; Geoffrey Kemball-Cook
A Tyr346-->Cys substitution in the interdomain acidic region a1 of factor VIII in an individual with factor VIII:C assay discrepancy.
British journal of haematology 2002;118(2):589-94.
2001: D Chen; K Riesbeck; John H McVey; Geoffrey Kemball-Cook; Edward G D Tuddenham; Robert I Lechler; Anthony Dorling
Human thrombin and FXa mediate porcine endothelial cell activation; modulation by expression of TFPI-CD4 and hirudin-CD4 fusion proteins.
Xenotransplantation 2001;8(4):258-65.
2001: Dezsö David; Evgueni L Saenko; I M Santos; D J Johnson; Edward G D Tuddenham; John H McVey; Geoffrey Kemball-Cook
Stable recombinant expression and characterization of the two haemophilic factor VIII variants C329S (CRM(-)) and G1948D (CRM(r)).
British journal of haematology 2001;113(3):604-15.
2001: John H McVey; E Boswell; Andrew D Mumford; Geoffrey Kemball-Cook; Edward G D Tuddenham
Factor VII deficiency and the FVII mutation database.
Human mutation 2001;17(1):3-17.
2000: Célia Ventura; A I Santos; A Tavares; Teresa Gago; João Lavinha; John H McVey; Dezsö David
Molecular genetic analysis of factor XI deficiency: identification of five novel gene alterations and the origin of type II mutation in Portuguese families.
Thrombosis and haemostasis 2000;84(5):833-40.
2000: David S Millar; Geoffrey Kemball-Cook; John H McVey; Edward G D Tuddenham; Andrew D Mumford; G B Attock; Joan Carles Reverter; N Lanir; Liakat A Parapia; J Reynaud; E Meili; A von Felton; Uri martinowitz; D R Prangnell; Michael Krawczak; David N Cooper
Molecular analysis of the genotype-phenotype relationship in factor VII deficiency.
Human genetics 2000;107(4):327-42.
2000: Masaru Shibata; Midori Shima; Shogo Morichika; John H McVey; Edward G D Tuddenham; Ichiro Tanaka; Hiroshi Suzuki; Keiji Nogami; Yoko Minamoto; Takaaki Hato; Evgueni L Saenko; Dorothea Scandella; Akira Yoshioka
An alloantibody recognizing the FVIII A1 domain in a patient with CRM reduced haemophilia A due to deletion of a large portion of the A1 domain DNA sequence.
Thrombosis and haemostasis 2000;84(3):442-8.
2000: Anthony Dorling; D Chen; K Riesbeck; John H McVey; Geoffrey Kemball-Cook; Edward G D Tuddenham; Robert I Lechler
Regulated endothelial cell expression of novel anticoagulants: a strategy for the prevention and therapy of intravascular thrombosis.
Transplantation proceedings 2000;32(5):971.
1999: D Chen; K Riesbeck; John H McVey; Geoffrey Kemball-Cook; E G Tuddenham; Robert I Lechler; Anthony Dorling
Regulated inhibition of coagulation by porcine endothelial cells expressing P-selectin-tagged hirudin and tissue factor pathway inhibitor fusion proteins.
Transplantation 1999;68(6):832-9.
1999: John H McVey
Tissue factor pathway.
Baillière's best practice & research. Clinical haematology 1999;12(3):361-72.
1999: D Chen; K Riesbeck; Geoffrey Kemball-Cook; John H McVey; Edward G D Tuddenham; Robert I Lechler; Anthony Dorling
Inhibition of tissue factor-dependent and -independent coagulation by cell surface expression of novel anticoagulant fusion proteins.
Transplantation 1999;67(3):467-74.
1999: K M Johnson; John H McVey
Molecular Analysis in Factor XI Deficiency.
Methods in molecular medicine 1999;31():211-21.
1998: K Riesbeck; D Chen; Geoffrey Kemball-Cook; John H McVey; A J George; E G Tuddenham; Anthony Dorling; Robert I Lechler
Expression of hirudin fusion proteins in mammalian cells: a strategy for prevention of intravascular thrombosis.
Circulation 1998;98(24):2744-52.
1998: E P Mansvelt; Michael A Laffan; John H McVey; Edward G D Tuddenham
Analysis of the F8 gene in individuals with high plasma factor VIII: C levels and associated venous thrombosis.
Thrombosis and haemostasis 1998;80(4):561-5.
1998: John H McVey; E J Boswell; O Takamiya; G Tamagnini; V Valente; T Fidalgo; Mark Layton; Edward G D Tuddenham
Exclusion of the first EGF domain of factor VII by a splice site mutation causes lethal factor VII deficiency.
Blood 1998;92(3):920-6.
1998: Edward G D Tuddenham; John H McVey
The genetic basis of inhibitor development in haemophilia A.
Haemophilia : the official journal of the World Federation of Hemophilia 1998;4(4):543-5.
1998: Geoffrey Kemball-Cook; D J Johnson; O Takamiya; D W Banner; John H McVey; Edward G D Tuddenham
Coagulation factor VII Gln100 --> Arg. Amino acid substitution at the epidermal growth factor 2-protease domain interface results in severely reduced tissue factor binding and procoagulant function.
The Journal of biological chemistry 1998;273(14):8516-21.
1997: K Riesbeck; Anthony Dorling; Geoffrey Kemball-Cook; John H McVey; M Jones; E G Tuddenham; Robert I Lechler
Human tissue factor pathway inhibitor fused to CD4 binds both FXa and TF/FVIIa at the cell surface.
Thrombosis and haemostasis 1997;78(6):1488-94.
1997: Shogo Morichika; Midori Shima; Seiki Kamisue; Ichiro Tanaka; Y Imanaka; Hiroshi Suzuki; H Shibata; S Pemberton; K Gale; John H McVey; Edward G D Tuddenham; Akira Yoshioka
Factor VIII gene analysis in Japanese CRM-positive and CRM-reduced haemophilia A patients by single-strand conformation polymorphism.
British journal of haematology 1997;98(4):901-6.
1995: Y Imanaka; K Lal; T Nishimura; P H Bolton-Maggs; Edward G D Tuddenham; John H McVey
Identification of two novel mutations in non-Jewish factor XI deficiency.
British journal of haematology 1995;90(4):916-20.
1994: D P O'Brien; Geoffrey Kemball-Cook; A M Hutchinson; D M Martin; D J Johnson; P G Byfield; O Takamiya; Edward G D Tuddenham; John H McVey
Surface plasmon resonance studies of the interaction between factor VII and tissue factor. Demonstration of defective tissue factor binding in a variant FVII molecule (FVII-R79Q).
Biochemistry 1994;33(47):14162-9.
1994: A C Nathwani; K M Gale; K D Pemberton; D C Crossman; Edward G D Tuddenham; John H McVey
Efficient gene transfer into human umbilical vein endothelial cells allows functional analysis of the human tissue factor gene promoter.
British journal of haematology 1994;88(1):122-8.
1994: L Kochhan; M R Lalloz; Johannes Oldenburg; John H McVey; K Olek; Hans H Brackmann; Edward G D Tuddenham; Rainer Schwaab
Haemophilia A diagnosis by automated fluorescent DNA detection of ten factor VIII intron 13 dinucleotide repeat alleles.
Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis 1994;5(4):497-501.
1994: M R Lalloz; Rainer Schwaab; John H McVey; K Michaelides; Edward G D Tuddenham
Haemophilia A diagnosis by simultaneous analysis of two variable dinucleotide tandem repeats within the factor VIII gene.
British journal of haematology 1994;86(4):804-9.
1994: Geoffrey Kemball-Cook; I Garner; Y Imanaka; T Nishimura; D P O'Brien; Edward G D Tuddenham; John H McVey
High-level production of human blood coagulation factors VII and XI using a new mammalian expression vector.
Gene 1994;139(2):275-9.
1993: John H McVey; K Michaelides; L P Hansen; M Ferguson-Smith; S Tilghman; R Krumlauf; Edward G D Tuddenham
A G-->A substitution in an HNF I binding site in the human alpha-fetoprotein gene is associated with hereditary persistence of alpha-fetoprotein (HPAFP).
Human molecular genetics 1993;2(4):379-84.
1991: M R Lalloz; John H McVey; J K Pattinson; Edward G D Tuddenham
Haemophilia A diagnosis by analysis of a hypervariable dinucleotide repeat within the factor VIII gene.
Lancet 1991;338(8761):207-11.
1991: D P O'Brien; K M Gale; J S Anderson; John H McVey; G J Miller; T W Meade; Edward G D Tuddenham
Purification and characterization of factor VII 304-Gln: a variant molecule with reduced activity isolated from a clinically unaffected male.
Blood 1991;78(1):132-40.
1991: Rainer Schwaab; M Ludwig; L Kochhan; Johannes Oldenburg; John H McVey; H Egli; Hans H Brackmann; K Olek
Detection and characterisation of two missense mutations at a cleavage site in the factor VIII light chain.
Thrombosis research 1991;61(3):225-34.
1990: J K Pattinson; D S Millar; John H McVey; C B Grundy; K Wieland; R S Mibashan; Uri martinowitz; K Tan-Un; M Vidaud; M Goossens
The molecular genetic analysis of hemophilia A: a directed search strategy for the detection of point mutations in the human factor VIII gene.
Blood 1990;76(11):2242-8.
1990: D C Crossman; D P Carr; Edward G D Tuddenham; Jeremy Pearson; John H McVey
The regulation of tissue factor mRNA in human endothelial cells in response to endotoxin or phorbol ester.
The Journal of biological chemistry 1990;265(17):9782-7.
1990: J K Pattinson; John H McVey; M Boon; A Ajani; Edward G D Tuddenham
CRM+ haemophilia A due to a missense mutation (372----Cys) at the internal heavy chain thrombin cleavage site.
British journal of haematology 1990;75(1):73-7.
1990: E M Paleolog; D C Crossman; John H McVey; Jeremy Pearson
Differential regulation by cytokines of constitutive and stimulated secretion of von Willebrand factor from endothelial cells.
Blood 1990;75(3):688-95.