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Sina Bavari

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Karen A O Martins; Travis K Warren; Sina Bavari
Characterization of a putative filovirus vaccine: Virus-like particles.
Peter B Madrid; Ian D Manger; Walter H Moos; Rekha G Panchal; Jean L Patterson; Amy C Shurtleff; Travis K Warren; Jay B Wells; Sina Bavari; Raelyn L Burke; Ricardo Carrion; Sidharth Chopra; Robert A Davey; Holli Hutcheson Dilks; Lynne Gilfillan; Carol E Green; Lalitha V Iyer; Tiffany R Keepers; Andrey A Kolokoltsov; Mary J Tanga
A Systematic Screen of FDA-Approved Drugs for Inhibitors of Biological Threat Agents.
Ramon M Felciano; Sina Bavari; Jean-Noel Billaud; Rekha Panchal; Daniel R Richards; Travis Warren; Andreas Krämer
Predictive systems biology approach to broad-spectrum, host-directed drug target discovery in infectious diseases.

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All Publications

2013: Karen A O Martins; Travis K Warren; Sina Bavari
Characterization of a putative filovirus vaccine: Virus-like particles.
Virologica Sinica 2013;28(2):65-70.
2013: Peter B Madrid; Ian D Manger; Walter H Moos; Rekha G Panchal; Jean L Patterson; Amy C Shurtleff; Travis K Warren; Jay B Wells; Sina Bavari; Raelyn L Burke; Ricardo Carrion; Sidharth Chopra; Robert A Davey; Holli Hutcheson Dilks; Lynne Gilfillan; Carol E Green; Lalitha V Iyer; Tiffany R Keepers; Andrey A Kolokoltsov; Mary J Tanga
A Systematic Screen of FDA-Approved Drugs for Inhibitors of Biological Threat Agents.
PloS one 2013;8(4):e60579.
2013: Ramon M Felciano; Sina Bavari; Jean-Noel Billaud; Rekha Panchal; Daniel R Richards; Travis Warren; Andreas Krämer
Predictive systems biology approach to broad-spectrum, host-directed drug target discovery in infectious diseases.
Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing 2013;():17-28.
2013: Krishna P Kota; Douglas Lane; Sina Bavari; Brett Eaton; James G Jaissle; Gianluca Pegoraro; Brian D Peyser; Camenzind G Robinson; Melanie Ulrich; Ricky Ulrich; Rekha G Panchal
Integrating high-content imaging and chemical genetics to probe host cellular pathways critical for Yersinia pestis infection.
PloS one 2013;8(1):e55167.
2013: Rekha G Panchal; Helena I Boshoff; Terry L Bowlin; Michelle M Butler; Douglas Lane; Donald T Moir; Sina Bavari
Bis-imidazolinylindoles are active against methicillin-resistant Staphylococcus aureus and multidrug-resistant Mycobacterium tuberculosis.
The Journal of antibiotics 2013;66(1):47-9.
2013: Jens H Kuhn; Sheli R Radoshitzky; Sina Bavari; Peter B Jahrling
The International Code of Virus Classification and Nomenclature (ICVCN): proposal to delete Rule 3.41.
Archives of virology 2013;158(1):297-9.
2012: Amy C Shurtleff; Ricardo Carrion; Samuel S Edwin; Nicole Garza; Anthony Griffiths; Matthew Lackemeyer; Jean Patterson; Sina Bavari
The impact of regulations, safety considerations and physical limitations on research progress at maximum biocontainment.
Viruses 2012;4(12):3932-51.
2012: Amy C Shurtleff; Elizabeth E Zumbrun; Kendra J Alfson; Jennifer L Audet; Sina Bavari; Julia E Biggins; Holly A Bloomfield; Anthony Griffiths; Ashley E Keeney; Ana Kuehne; Gene G Olinger
Standardization of the filovirus plaque assay for use in preclinical studies.
Viruses 2012;4(12):3511-30.
2012: Patrick L Iversen; Dan V Mourich; Rekha G Panchal; Travis K Warren; Lisa S Welch; Jay B Wells; Nicole L Garza; Sina Bavari
Discovery and early development of AVI-7537 and AVI-7288 for the treatment of Ebola virus and Marburg virus infections.
Viruses 2012;4(11):2806-30.
2012: Krishna P Kota; Rajini Mudhasani; Sina Bavari; Jacqueline G Benko; Cary Retterer; Julie P Tran; Rekha G Panchal
High content image based analysis identifies cell cycle inhibitors as regulators of Ebola virus infection.
Viruses 2012;4(10):1865-77.
2012: Rekha G Panchal; Bruce L Geller; Patrick L Iversen; Douglas Lane; Brett Mellbye; Sina Bavari
Peptide conjugated phosphorodiamidate morpholino oligomers increase survival of mice challenged with Ames Bacillus anthracis.
Nucleic acid therapeutics 2012;22(5):316-22.
2012: Amy C Shurtleff; David A Kingery; Tam L Nguyen; Sina Bavari
Therapeutics for filovirus infection: traditional approaches and progress towards in silico drug design.
Expert opinion on drug discovery 2012;7(10):935-54.
2012: Stephanie M Stanford; Logan M Walker; Dennis J Wu; Sheng Zhang; Zhong-Yin Zhang; Sagar S Damle; Matthew D Falk; Teodora Kaltcheva; Sayantan Mitra; Rekha G Panchal; David Ruble; Amy M Barrios; Sina Bavari; Nunzio Bottini
High-throughput screen using a single-cell tyrosine phosphatase assay reveals biologically active inhibitors of tyrosine phosphatase CD45.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(35):13972-7.
2012: Gianluca Pegoraro; Sina Bavari; Rekha G Panchal
Shedding light on filovirus infection with high-content imaging.
Viruses 2012;4(8):1354-71.
2012: Zivota Selaković; Bogdan Solaja; Cary Retterer; Sina Bavari; James C Burnett; Brett Eaton; Dejan Opsenica; Rekha G Panchal
A limited structural modification results in a significantly more efficacious diazachrysene-based filovirus inhibitor.
Viruses 2012;4(8):1279-88.
2012: Sheli R Radoshitzky; Fabian de Kok-Mercado; Peter B Jahrling; Jens H Kuhn; Sina Bavari
Drug discovery technologies and strategies for Machupo virus and other New World arenaviruses.
Expert opinion on drug discovery 2012;7(7):613-32.
2012: Igor Opsenica; Bogdan Solaja; James C Burnett; Vuk Filipovic; Laura M Gomba; Rick Gussio; Jon E Nuss; Dejan Opsenica; Sina Bavari
The synthesis of 2,5-bis(4-amidinophenyl)thiophene derivatives providing submicromolar-range inhibition of the botulinum neurotoxin serotype A metalloprotease.
European journal of medicinal chemistry 2012;53():374-9.
2012: Travis K Warren; Amy C Shurtleff; Sina Bavari
Advanced morpholino oligomers: a novel approach to antiviral therapy.
Antiviral research 2012;94(1):80-8.
2012: Jeffrey R Kugelman; Jens H Kuhn; Michael S Lee; Sarah E McCarthy; Sina Bavari; John Michael Dye; Lisa E Hensley; Anna N Honko; Peter B Jahrling; Sheli R Radoshitzky; Cynthia A Rossi; Travis K Warren; Chris A Whitehouse; Gustavo Palacios
Ebola virus genome plasticity as a marker of its passaging history: a comparison of in vitro passaging to non-human primate infection.
PloS one 2012;7(11):e50316.
2012: Leslie P Silva; Michael Vanzile; J M Javad Aman; Sina Bavari; David C Schriemer
Assembly of Ebola virus matrix protein VP40 is regulated by latch-like properties of N and C terminal tails.
PloS one 2012;7(7):e39978.
2011: Bing Li; Jonathan E Nuss; Ramdas Pai; Norton P Peet; Sina Bavari; Michelle M Butler; Steven C Cardinale; Terry L Bowlin
Time-dependent botulinum neurotoxin serotype A metalloprotease inhibitors.
Bioorganic & medicinal chemistry 2011;19(24):7338-48.
2011: Sheli R Radoshitzky; Cary Retterer; Viktor Volchkov; Victoria Wahl-Jensen; Kelly L Warfield; John N Misasi; M Javad Aman; Sina Bavari; Steven B Bradfute; Xiaoli Chi; James M Cunningham; Lian Dong; Michael Farzan; Jacqueline D Gearhart; Marc A Hogenbirk; Peter B Jahrling; Krishna Kota; Philip J Kranzusch; Jens H Kuhn
Ebolavirus delta-peptide immunoadhesins inhibit marburgvirus and ebolavirus cell entry.
Journal of virology 2011;85(17):8502-13.
2011: Steven B Bradfute; Sina Bavari
Correlates of immunity to filovirus infection.
Viruses 2011;3(7):982-1000.
2011: Steven B Bradfute; John Michael Dye; Sina Bavari
Filovirus vaccines.
Human vaccines 2011;7(6):701-11.
2011: Wu Ou; Josie Delisle; Krishnamurthy Konduru; Steven Bradfute; Sheli R Radoshitzky; Cary Retterer; Krishna Kota; Sina Bavari; Jens H Kuhn; Peter B Jahrling; Gerardo Kaplan; Carolyn A Wilson
Development and characterization of rabbit and mouse antibodies against ebolavirus envelope glycoproteins.
Journal of virological methods 2011;174(1-2):99-109.
2011: Emily Happy Miller; Joseph S Harrison; Sheli R Radoshitzky; Chelsea D Higgins; Xiaoli Chi; Lian Dong; Jens H Kuhn; Sina Bavari; Jonathan Lai; Kartik Chandran
Inhibition of Ebola virus entry by a C-peptide targeted to endosomes.
The Journal of biological chemistry 2011;286(18):15854-61.
2011: Maryam Keshtkar-Jahromi; Jens H Kuhn; Iva Christova; Steven B Bradfute; Peter B Jahrling; Sina Bavari
Crimean-Congo hemorrhagic fever: current and future prospects of vaccines and therapies.
Antiviral research 2011;90(2):85-92.
2011: Erkan Kiris; Jonathan E Nuss; James C Burnett; Krishna P Kota; Dawn C Koh; Laura M Wanner; Edna Torres-Melendez; Rick Gussio; Lino Tessarollo; Sina Bavari
Embryonic stem cell-derived motoneurons provide a highly sensitive cell culture model for botulinum neurotoxin studies, with implications for high-throughput drug discovery.
Stem cell research 2011;6(3):195-205.
2011: Krishnamurthy Konduru; Steven B Bradfute; Jerome Jacques; Mohanraj Manangeeswaran; Siham Nakamura; Sufi Morshed; Steven C Wood; Sina Bavari; Gerardo G Kaplan
Ebola virus glycoprotein Fc fusion protein confers protection against lethal challenge in vaccinated mice.
Vaccine 2011;29(16):2968-77.
2011: Loreen L Lofts; Jay B Wells; Sina Bavari; Kelly L Warfield
Key genomic changes necessary for an in vivo lethal mouse marburgvirus variant selection process.
Journal of virology 2011;85(8):3905-17.
2011: Arnab Basu; Bing Li; Debra M Mills; Rekha G Panchal; Steven C Cardinale; Michelle M Butler; Norton P Peet; Helena Majgier-Baranowska; John D Williams; Ishan Patel; Donald T Moir; Sina Bavari; Ranjit Ray; Michael R Farzan; Li Rong; Terry L Bowlin
Identification of a small-molecule entry inhibitor for filoviruses.
Journal of virology 2011;85(7):3106-19.
2011: Igor Opsenica; James C Burnett; Rick Gussio; Dejan Opsenica; Nina Todorović; Charlotte A Lanteri; Richard J Sciotti; Montip Gettayacamin; Nicoletta Basilico; Donatella Taramelli; Jonathan E Nuss; Laura Wanner; Rekha G Panchal; Bogdan A Solaja; Sina Bavari
A chemotype that inhibits three unrelated pathogenic targets: the botulinum neurotoxin serotype A light chain, P. falciparum malaria, and the Ebola filovirus.
Journal of medicinal chemistry 2011;54(5):1157-69.
2011: Amy C Shurtleff; Travis K Warren; Sina Bavari
Nonhuman primates as models for the discovery and development of ebolavirus therapeutics.
Expert opinion on drug discovery 2011;6(3):233-50.
2011: Gordon Ruthel; Sarah J Sandwick; Edna Torres-Melendez; Lyal E Tressler; Laura M Wanner; James C Burnett; Jonathan E Nuss; Cary J Retterer; Sina Bavari
Post-intoxication inhibition of botulinum neurotoxin serotype a within neurons by small-molecule, non-peptidic inhibitors.
Toxins 2011;3(3):207-17.
2011: Haitao Guo; Xiaoben Pan; Richeng Mao; Xianchao Zhang; Lijuan Wang; Xuanyong Lu; Jinhong Chang; Ju-Tao Guo; Shendra Passic; Fred C Krebs; Brian Wigdahl; Travis K Warren; Cary J Retterer; Sina Bavari; Xiaodong Xu; Andrea Cuconati; Timothy M Block
Alkylated porphyrins have broad antiviral activity against hepadnaviruses, flaviviruses, filoviruses, and arenaviruses.
Antimicrobial agents and chemotherapy 2011;55(2):478-86.
2011: Sheli R Radoshitzky; Cary Retterer; John Carra; Jeremiah C Clester; Lian Dong; Krishna Kota; Jens H Kuhn; Lindsay E Longobardi; Sina Bavari
Machupo virus glycoprotein determinants for human transferrin receptor 1 binding and cell entry.
PloS one 2011;6(7):e21398.
2011: Steven B Bradfute; Amy C Shurtleff; Kelly S Stuthman; Sina Bavari
A STAT-1 knockout mouse model for Machupo virus pathogenesis.
Virology journal 2011;8():300.
2011: I-Chueh Huang; Charles C Bailey; Jessica L Weyer; Sheli R Radoshitzky; Michelle M Becker; Jessica J Chiang; Abraham L Brass; Asim A Ahmed; Xiaoli Chi; Lian Dong; Lindsay E Longobardi; Dutch Boltz; Jens H Kuhn; Stephen J Elledge; Sina Bavari; Mark R Denison; Hyeryun Choe; Michael Farzan
Distinct patterns of IFITM-mediated restriction of filoviruses, SARS coronavirus, and influenza A virus.
PLoS pathogens 2011;7(1):e1001258.
2010: Kevin B Spurgers; Tim Alefantis; Brian D Peyser; Gordon T Ruthel; Alison A Bergeron; Julie A Costantino; Sven Enterlein; Krishna P Kota; R C Dutch Boltz; M Javad Aman; Vito G DelVecchio; Sina Bavari
Identification of essential filovirion-associated host factors by serial proteomic analysis and RNAi screen.
Molecular & cellular proteomics : MCP 2010;9(12):2690-703.
2010: Philip J Kranzusch; Andreas D Schenk; Amal Rahmeh; Sheli R Radoshitzky; Sina Bavari; Thomas Walz; Sean Whelan
Assembly of a functional Machupo virus polymerase complex.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(46):20069-74.
2010: Sheli R Radoshitzky; Lian Dong; Xiaoli Chi; Jeremiah C Clester; Cary Retterer; Kevin Spurgers; Jens H Kuhn; Sarah Sandwick; Gordon Ruthel; Krishna Kota; Dutch Boltz; Travis Warren; Philip J Kranzusch; Sean Whelan; Sina Bavari
Infectious Lassa virus, but not filoviruses, is restricted by BST-2/tetherin.
Journal of virology 2010;84(20):10569-80.
2010: Travis K Warren; Kelly L Warfield; Jay Wells; Dana L Swenson; Kelly S Donner; Sean A Van Tongeren; Nicole L Garza; Lian Dong; Dan V Mourich; Stacy Crumley; Donald K Nichols; Patrick L Iversen; Sina Bavari
Advanced antisense therapies for postexposure protection against lethal filovirus infections.
Nature medicine 2010;16(9):991-4.
2010: Jonathan E Nuss; Laura M Wanner; Lyal E Tressler; Sina Bavari
The osmolyte trimethylamine N-oxide (TMAO) increases the proteolytic activity of botulinum neurotoxin light chains A, B, and E: implications for enhancing analytical assay sensitivity.
Journal of biomolecular screening 2010;15(8):928-36.
2010: Michelle M Butler; John D Williams; Norton P Peet; Donald T Moir; Rekha G Panchal; Sina Bavari; Dean L Shinabarger; Terry L Bowlin
Comparative in vitro activity profiles of novel bis-indole antibacterials against gram-positive and gram-negative clinical isolates.
Antimicrobial agents and chemotherapy 2010;54(9):3974-7.
2010: Rekha G Panchal; Krishna P Kota; Kevin B Spurgers; Gordon Ruthel; Julie P Tran; Robert C Dutch Boltz; Sina Bavari
Development of high-content imaging assays for lethal viral pathogens.
Journal of biomolecular screening 2010;15(7):755-65.
2010: Richard L Felts; Kedar Narayan; Jacob D Estes; Dan Shi; Charles M Trubey; Jing Fu; Lisa M Hartnell; Gordon T Ruthel; Douglas K Schneider; Kunio Nagashima; Julian W Bess; Sina Bavari; Bradley C Lowekamp; DONALD BLISS; Jeffrey D Lifson; Sriram Subramaniam
3D visualization of HIV transfer at the virological synapse between dendritic cells and T cells.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(30):13336-41.
2010: Suchita Bhattacharyya; Kelly L Warfield; Gordon Ruthel; Sina Bavari; M Javad Aman; Thomas J Hope
Ebola virus uses clathrin-mediated endocytosis as an entry pathway.
Virology 2010;401(1):18-28.
2010: Travis K Warren; Kelly L Warfield; Jay Wells; Sven Enterlein; Mark Smith; Gordon Ruthel; Abdul S Yunus; Michael S Kinch; Michael Goldblatt; M Javad Aman; Sina Bavari
Antiviral activity of a small-molecule inhibitor of filovirus infection.
Antimicrobial agents and chemotherapy 2010;54(5):2152-9.
2010: Ramin Mollaaghababa Hakami; Gordon Ruthel; Andrea M Stahl; Sina Bavari
Gaining ground: assays for therapeutics against botulinum neurotoxin.
Trends in microbiology 2010;18(4):164-72.
2010: Timothy J Opperman; John D Williams; Chad Houseweart; Rekha G Panchal; Sina Bavari; Norton P Peet; Donald T Moir; Terry L Bowlin
Efflux-mediated bis-indole resistance in Staphylococcus aureus reveals differential substrate specificities for MepA and MepR.
Bioorganic & medicinal chemistry 2010;18(6):2123-30.
2010: Bing Li; Ramdas Pai; Steven C Cardinale; Michelle M Butler; Norton P Peet; Donald T Moir; Sina Bavari; Terry L Bowlin
Synthesis and biological evaluation of botulinum neurotoxin a protease inhibitors.
Journal of medicinal chemistry 2010;53(5):2264-76.
2010: Brian Drozdowski; Yuhong Zhou; Brad Kline; Jared Spidel; Yin Yin Chan; Earl Albone; Howard Turchin; Qimin Chao; Marianne Henry; Jacqueline Balogach; Eric Routhier; Sina Bavari; Nicholas C Nicolaides; Philip M Sass; Luigi Grasso
Generation and characterization of high affinity human monoclonal antibodies that neutralize staphylococcal enterotoxin B.
Journal of immune based therapies and vaccines 2010;8():9.
2010: Jorge E Zuniga; Jared T Hammill; Omri Drory; Jonathan E Nuss; James C Burnett; Rick Gussio; Peter Wipf; Sina Bavari; Axel T Brunger
Iterative structure-based peptide-like inhibitor design against the botulinum neurotoxin serotype A.
PloS one 2010;5(6):e11378.
2010: Steven B Bradfute; Paul E Swanson; Mark A Smith; Eizo Watanabe; Jonathan E McDunn; Richard S Hotchkiss; Sina Bavari
Mechanisms and consequences of ebolavirus-induced lymphocyte apoptosis.
Journal of immunology (Baltimore, Md. : 1950) 2010;184(1):327-35.
2010: Jonathan E Nuss; Gordon Ruthel; Lyal E Tressler; Laura M Wanner; Edna Torres-Melendez; Martha Hale; Sina Bavari
Development of cell-based assays to measure botulinum neurotoxin serotype A activity using cleavage-sensitive antibodies.
Journal of biomolecular screening 2010;15(1):42-51.
2009: Rosangela Noberga Mezghanni; Matthew J Hepburn; Sina Bavari; Marcelo B Sztein
Generation of heterogeneous memory T cells by live attenuated tularemia vaccine in humans.
Vaccine 2009;28(1):195-206.
2009: Rekha G Panchal; Ricky L Ulrich; Douglas Lane; Michelle M Butler; Chad Houseweart; Timothy Opperman; John D Williams; Norton P Peet; Donald T Moir; Tam Nguyen; Rick Gussio; Terry Bowlin; Sina Bavari
Novel broad-spectrum bis-(imidazolinylindole) derivatives with potent antibacterial activities against antibiotic-resistant strains.
Antimicrobial agents and chemotherapy 2009;53(10):4283-91.
2009: M Javad Aman; Michael S Kinch; Kelly L Warfield; Travis Warren; Abdul Yunus; Sven Enterlein; Eric Stavale; Peifang Wang; Shaojing Chang; Qingsong Tang; Kevin Porter; Michael Goldblatt; Sina Bavari
Development of a broad-spectrum antiviral with activity against Ebola virus.
Antiviral research 2009;83(3):245-51.
2009: Rekha G Panchal; Steven B Bradfute; Brian D Peyser; Kelly L Warfield; Gordon Ruthel; Douglas Lane; Tara A Kenny; Arthur O. Anderson; William C Raschke; Sina Bavari
Reduced levels of protein tyrosine phosphatase CD45 protect mice from the lethal effects of Ebola virus infection.
Cell host & microbe 2009;6(2):162-73.
2009: Kelly L Warfield; Steven B Bradfute; Jay Wells; Loreen Lofts; Meagan T Cooper; D Anthony Alves; Daniel K Reed; Sean A VanTongeren; Christine A Mech; Sina Bavari
Development and characterization of a mouse model for Marburg hemorrhagic fever.
Journal of virology 2009;83(13):6404-15.
2009: Rekha G Panchal; Ricky L Ulrich; Steven B Bradfute; Douglas Lane; Gordon Ruthel; Tara A Kenny; Patrick L Iversen; Arthur O. Anderson; Rick Gussio; William C Raschke; Sina Bavari
Reduced expression of CD45 protein-tyrosine phosphatase provides protection against anthrax pathogenesis.
The Journal of biological chemistry 2009;284(19):12874-85.
2009: Kelly L Warfield; Emily M Deal; Sina Bavari
Filovirus infections.
Journal of the American Veterinary Medical Association 2009;234(9):1130-9.
2009: Dana L Swenson; Kelly L Warfield; Travis K Warren; Candace Lovejoy; Jed N Hassinger; Gordon Ruthel; Robert E Blouch; Hong M Moulton; Dwight D Weller; Patrick L Iversen; Sina Bavari
Chemical modifications of antisense morpholino oligomers enhance their efficacy against Ebola virus infection.
Antimicrobial agents and chemotherapy 2009;53(5):2089-99.
2009: Warren V Kalina; Kelly L Warfield; Gene Garrard Olinger; Sina Bavari
Discovery of common marburgvirus protective epitopes in a BALB/c mouse model.
Virology journal 2009;6():132.
2008: Jorge E Zuniga; James J Schmidt; Timothy Fenn; James C Burnett; Demet Araç; Rick Gussio; Robert G Stafford; Shirin S Badie; Sina Bavari; Axel T Brunger
A potent peptidomimetic inhibitor of botulinum neurotoxin serotype A has a very different conformation than SNAP-25 substrate.
Structure (London, England : 1993) 2008;16(10):1588-97.
2008: Bogdan A Solaja; Dejan Opsenica; Kirsten S Smith; Wilbur K Milhous; Natasa Terzić; Igor Opsenica; James C Burnett; Jon Nuss; Rick Gussio; Sina Bavari
Novel 4-aminoquinolines active against chloroquine-resistant and sensitive P. falciparum strains that also inhibit botulinum serotype A.
Journal of medicinal chemistry 2008;51(15):4388-91.
2008: Brian J Nablo; Kelly M Halverson; Joseph W F Robertson; Tam L Nguyen; Rekha G Panchal; Rick Gussio; Sina Bavari; Oleg V Krasilnikov; John Kasianowicz
Sizing the Bacillus anthracis PA63 channel with nonelectrolyte poly(ethylene glycols).
Biophysical journal 2008;95(3):1157-64.
2008: Dana L Swenson; Kelly L Warfield; Tom Larsen; D Anthony Alves; Sadie S Coberley; Sina Bavari
Monovalent virus-like particle vaccine protects guinea pigs and nonhuman primates against infection with multiple Marburg viruses.
Expert review of vaccines 2008;7(4):417-29.
2008: Yumiko Imai; Keiji Kuba; G Greg Neely; Rubina Yaghubian-Malhami; Thomas Perkmann; Geert van Loo; Maria Ermolaeva; Ruud Veldhuizen; Y H Connie Leung; Hongliang Wang; Haolin Liu; Yang Sun; Manolis Pasparakis; Manfred Kopf; Christin Mech; Sina Bavari; J S M Peiris; Arthur Slutsky; Shizuo Akira; Malin Hultqvist; Rikard Holmdahl; John Nicholls; Chengyu Jiang; Christoph J Binder; Josef M Penninger
Identification of oxidative stress and Toll-like receptor 4 signaling as a key pathway of acute lung injury.
Cell 2008;133(2):235-49.
2008: Kevin B Spurgers; C Matthew Sharkey; Kelly L Warfield; Sina Bavari
Oligonucleotide antiviral therapeutics: antisense and RNA interference for highly pathogenic RNA viruses.
Antiviral research 2008;78(1):26-36.
2008: Steven B Bradfute; Kelly L Warfield; Sina Bavari
Functional CD8+ T cell responses in lethal Ebola virus infection.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(6):4058-66.
2007: Kelly L Warfield; Dana L Swenson; Gene Garrard Olinger; Warren V Kalina; M Javad Aman; Sina Bavari
Ebola virus-like particle-based vaccine protects nonhuman primates against lethal Ebola virus challenge.
The Journal of infectious diseases 2007;196 Suppl 2():S430-7.
2007: Kelly L Warfield; Nichole A Posten; Dana L Swenson; Gene Garrard Olinger; Dominic Esposito; William K Gillette; Ralph F Hopkins; Julie Costantino; Rekha G Panchal; James L Hartley; M Javad Aman; Sina Bavari
Filovirus-like particles produced in insect cells: immunogenicity and protection in rodents.
The Journal of infectious diseases 2007;196 Suppl 2():S421-9.
2007: Kelly L Warfield; Dana L Swenson; Gene Garrard Olinger; Warren V Kalina; Mathias Viard; Mohamed Aitichou; Xiaoli Chi; Sofi Ibrahim; Robert Blumenthal; Yossef Raviv; Sina Bavari; M Javad Aman
Ebola virus inactivation with preservation of antigenic and structural integrity by a photoinducible alkylating agent.
The Journal of infectious diseases 2007;196 Suppl 2():S276-83.
2007: Lynn S Silvestri; Gordon Ruthel; George Kallstrom; Kelly L Warfield; Dana L Swenson; Timothy Nelle; Patrick L Iversen; Sina Bavari; M Javad Aman
Involvement of vacuolar protein sorting pathway in Ebola virus release independent of TSG101 interaction.
The Journal of infectious diseases 2007;196 Suppl 2():S264-70.
2007: James C Burnett; Dejan Opsenica; Kamaraj Sriraghavan; Rekha G Panchal; Gordon Ruthel; Ann R Hermone; Tam L Nguyen; Tara A Kenny; Douglas J Lane; Connor F McGrath; James J Schmidt; Jonathan L Vennerstrom; Rick Gussio; Bogdan A Solaja; Sina Bavari
A refined pharmacophore identifies potent 4-amino-7-chloroquinoline-based inhibitors of the botulinum neurotoxin serotype A metalloprotease.
Journal of medicinal chemistry 2007;50(9):2127-36.
2007: Claudette L Fuller; Katherine C Brittingham; Mark Porter; Matthew J Hepburn; Patricia L Petitt; Phillip R Pittman; Sina Bavari
Transcriptome analysis of human immune responses following live vaccine strain (LVS) Francisella tularensis vaccination.
Molecular immunology 2007;44(12):3173-84.
2007: Claudette L Fuller; Gordon Ruthel; Kelly L Warfield; Dana L Swenson; Catharine M Bosio; M Javad Aman; Sina Bavari
NKp30-dependent cytolysis of filovirus-infected human dendritic cells.
Cellular microbiology 2007;9(4):962-76.
2007: Andrea M Stahl; Gordon Ruthel; Edna Torres-Melendez; Tara A Kenny; Rekha G Panchal; Sina Bavari
Primary cultures of embryonic chicken neurons for sensitive cell-based assay of botulinum neurotoxin: implications for therapeutic discovery.
Journal of biomolecular screening 2007;12(3):370-7.
2007: Rekha G Panchal; Gordon Ruthel; Katherine C Brittingham; Douglas Lane; Tara A Kenny; Rick Gussio; John Lazo; Sina Bavari
Chemical genetic screening identifies critical pathways in anthrax lethal toxin-induced pathogenesis.
Chemistry & biology 2007;14(3):245-55.
2007: James C Burnett; Gordon Ruthel; Christian Stegmann; Rekha G Panchal; Tam L Nguyen; Ann R Hermone; Robert G Stafford; Douglas J Lane; Tara A Kenny; Connor F McGrath; Peter Wipf; Andrea M Stahl; James J Schmidt; Rick Gussio; Axel T Brunger; Sina Bavari
Inhibition of metalloprotease botulinum serotype A from a pseudo-peptide binding mode to a small molecule that is active in primary neurons.
The Journal of biological chemistry 2007;282(7):5004-14.
2007: Kelly L Warfield; Derron A Alves; Steven B Bradfute; Daniel K Reed; Sean VanTongeren; Warren V Kalina; Gene Garrard Olinger; Sina Bavari
Development of a model for marburgvirus based on severe-combined immunodeficiency mice.
Virology journal 2007;4():108.
2006: Wilson J Ribot; Rekha G Panchal; Katherine C Brittingham; Gordon Ruthel; Tara A Kenny; Douglas Lane; Bob Curry; Timothy A Hoover; Arthur M Friedlander; Sina Bavari
Anthrax lethal toxin impairs innate immune functions of alveolar macrophages and facilitates Bacillus anthracis survival.
Infection and immunity 2006;74(9):5029-34.
2006: John E Herrmann; Shixia Wang; Chuanyou Zhang; Rekha G Panchal; Sina Bavari; C Rick Lyons; Julie Lovchik; Basil Golding; Joseph Shiloach; Shan Lu
Passive immunotherapy of Bacillus anthracis pulmonary infection in mice with antisera produced by DNA immunization.
Vaccine 2006;24(31-32):5872-80.
2006: Jens H Kuhn; Sheli R Radoshitzky; Alexander C Guth; Kelly L Warfield; Wenhui Li; Martin J Vincent; Jonathan S Towner; Stuart T Nichol; Sina Bavari; Hyeryun Choe; M Javad Aman; Michael Farzan
Conserved receptor-binding domains of Lake Victoria marburgvirus and Zaire ebolavirus bind a common receptor.
The Journal of biological chemistry 2006;281(23):15951-8.
2006: Claudette L Fuller; Katherine C Brittingham; Matthew J Hepburn; James W Martin; Patricia L Petitt; Phillip R Pittman; Sina Bavari
Dominance of human innate immune responses in primary Francisella tularensis live vaccine strain vaccination.
The Journal of allergy and clinical immunology 2006;117(5):1186-8.
2006: Kelly L Warfield; Rekha G Panchal; M Javad Aman; Sina Bavari
Antisense treatments for biothreat agents.
Current opinion in molecular therapeutics 2006;8(2):93-103.
2006: Sven Enterlein; Kelly L Warfield; Dana L Swenson; David A Stein; Jeffery L Smith; C Scott Gamble; Andrew D Kroeker; Patrick L Iversen; Sina Bavari; Elke Mühlberger
VP35 knockdown inhibits Ebola virus amplification and protects against lethal infection in mice.
Antimicrobial agents and chemotherapy 2006;50(3):984-93.
2006: Kelly L Warfield; Dana L Swenson; Gene Garrard Olinger; Donald K Nichols; William D Pratt; Robert Blouch; David A Stein; M Javad Aman; Patrick L Iversen; Sina Bavari
Gene-specific countermeasures against Ebola virus based on antisense phosphorodiamidate morpholino oligomers.
PLoS pathogens 2006;2(1):e1.
2005: Aysegul Nalca; Anne W Rimoin; Sina Bavari; Chris A Whitehouse
Reemergence of monkeypox: prevalence, diagnostics, and countermeasures.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2005;41(12):1765-71.
2005: Shakuntala Mangru; Bryan L Bentz; Timothy J Davis; Nitin Desai; Paul J Stabile; James J Schmidt; Charles B Millard; Sina Bavari; Krishna Kodukula
Integrated bioassays in microfluidic devices: botulinum toxin assays.
Journal of biomolecular screening 2005;10(8):788-94.
2005: Kelly M Halverson; Rekha G Panchal; Tam L Nguyen; Rick Gussio; Stephen F Little; Martin Misakian; Sina Bavari; John Kasianowicz
Anthrax biosensor, protective antigen ion channel asymmetric blockade.
The Journal of biological chemistry 2005;280(40):34056-62.
2005: Dorothy D Pless; Gordon Ruthel; Emily K Reinke; Robert G Ulrich; Sina Bavari
Persistence of zinc-binding bacterial superantigens at the surface of antigen-presenting cells contributes to the extreme potency of these superantigens as T-cell activators.
Infection and immunity 2005;73(9):5358-66.
2005: James C Burnett; Rekha G Panchal; M Javad Aman; Sina Bavari
The rapidly advancing field of biodefense benefits many other, critical public health concerns.
Discovery medicine 2005;5(28):371-7.
2005: Kelly L Warfield; Gene Garrard Olinger; Emily M Deal; Dana L Swenson; Michael Bailey; diane negley; Mary Kate Hart; Sina Bavari
Induction of humoral and CD8+ T cell responses are required for protection against lethal Ebola virus infection.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(2):1184-91.
2005: Tam L Nguyen; Guy Schoehn; Winfried Weissenhorn; Ann R Hermone; James C Burnett; Rekha G Panchal; Connor McGrath; Daniel W Zaharevitz; M Javad Aman; Rick Gussio; Sina Bavari
An all-atom model of the pore-like structure of hexameric VP40 from Ebola: structural insights into the monomer-hexamer transition.
Journal of structural biology 2005;151(1):30-40.
2005: George Kallstrom; Kelly L Warfield; Dana L Swenson; Shannon Mort; Rekha G Panchal; Gordon Ruthel; Sina Bavari; M Javad Aman
Analysis of Ebola virus and VLP release using an immunocapture assay.
Journal of virological methods 2005;127(1):1-9.
2005: Kelly L Warfield; Dana L Swenson; Gretchen Demmin; Sina Bavari
Filovirus-like particles as vaccines and discovery tools.
Expert review of vaccines 2005;4(3):429-40.
2005: Katherine C Brittingham; Gordon Ruthel; Rekha G Panchal; Claudette L Fuller; Wilson J Ribot; Timothy A Hoover; Howard A Young; Arthur O. Anderson; Sina Bavari
Dendritic cells endocytose Bacillus anthracis spores: implications for anthrax pathogenesis.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(9):5545-52.
2005: Dana L Swenson; Kelly L Warfield; diane negley; Alan L Schmaljohn; M Javad Aman; Sina Bavari
Virus-like particles exhibit potential as a pan-filovirus vaccine for both Ebola and Marburg viral infections.
Vaccine 2005;23(23):3033-42.
2005: James C Burnett; Erik A Henchal; Alan L Schmaljohn; Sina Bavari
The evolving field of biodefence: therapeutic developments and diagnostics.
Nature reviews. Drug discovery 2005;4(4):281-97.
2005: Gordon Ruthel; Gretchen L Demmin; George Kallstrom; Melodi P Javid; Shirin S Badie; Amy B Will; Timothy Nelle; Rowena D Schokman; Tam L Nguyen; John H Carra; Sina Bavari; M Javad Aman
Association of ebola virus matrix protein VP40 with microtubules.
Journal of virology 2005;79(8):4709-19.
2005: Chad J Roy; Kelly L Warfield; Brent C Welcher; Raoul F Gonzales; Tom Larsen; Julie Hanson; Chella S David; Teresa Krakauer; Sina Bavari
Human leukocyte antigen-DQ8 transgenic mice: a model to examine the toxicity of aerosolized staphylococcal enterotoxin B.
Infection and immunity 2005;73(4):2452-60.
2005: Rekha G Panchal; Kelly M Halverson; Wilson J Ribot; Douglas Lane; Tara A Kenny; Teresa G Abshire; John W Ezzell; Timothy A Hoover; Bradford Powell; Stephen Little; John Kasianowicz; Sina Bavari
Purified Bacillus anthracis lethal toxin complex formed in vitro and during infection exhibits functional and biological activity.
The Journal of biological chemistry 2005;280(11):10834-9.
2005: Mansour Mohamadzadeh; Scott Olson; Warren V Kalina; Gordon Ruthel; Gretchen L Demmin; Kelly L Warfield; Sina Bavari; Todd R Klaenhammer
Lactobacilli activate human dendritic cells that skew T cells toward T helper 1 polarization.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(8):2880-5.
2005: James C Burnett; James J Schmidt; Connor F McGrath; Tam L Nguyen; Ann R Hermone; Rekha G Panchal; Jonathan L Vennerstrom; Krishna Kodukula; Daniel W Zaharevitz; Rick Gussio; Sina Bavari
Conformational sampling of the botulinum neurotoxin serotype A light chain: implications for inhibitor binding.
Bioorganic & medicinal chemistry 2005;13(2):333-41.
2004: Kelly L Warfield; Dana L Swenson; diane negley; Alan L Schmaljohn; M Javad Aman; Sina Bavari
Marburg virus-like particles protect guinea pigs from lethal Marburg virus infection.
Vaccine 2004;22(25-26):3495-502.
2004: Catharine M Bosio; Bartlett D Moore; Kelly L Warfield; Gordon Ruthel; Mansour Mohamadzadeh; M Javad Aman; Sina Bavari
Ebola and Marburg virus-like particles activate human myeloid dendritic cells.
Virology 2004;326(2):280-7.
2004: Kelly L Warfield; Jeremy G Perkins; Dana L Swenson; Emily M Deal; Catharine M Bosio; M Javad Aman; Wayne M Yokoyama; Howard A Young; Sina Bavari
Role of natural killer cells in innate protection against lethal ebola virus infection.
The Journal of experimental medicine 2004;200(2):169-79.
2004: Gordon Ruthel; Wilson J Ribot; Sina Bavari; Timothy A Hoover
Time-lapse confocal imaging of development of Bacillus anthracis in macrophages.
The Journal of infectious diseases 2004;189(7):1313-6.
2004: Dana L Swenson; Kelly L Warfield; Kathleen Kuehl; Thomas Larsen; Michael Hevey; Alan L Schmaljohn; Sina Bavari; M Javad Aman
Generation of Marburg virus-like particles by co-expression of glycoprotein and matrix protein.
FEMS immunology and medical microbiology 2004;40(1):27-31.
2004: Rekha G Panchal; Ann R Hermone; Tam L Nguyen; Thiang Yian Wong; Robert Schwarzenbacher; James Schmidt; Douglas Lane; Connor McGrath; Benjamin E Turk; James Burnett; M Javad Aman; Stephen Little; Edward A Sausville; Daniel W Zaharevitz; Lewis C Cantley; Robert C Liddington; Rick Gussio; Sina Bavari
Identification of small molecule inhibitors of anthrax lethal factor.
Nature structural & molecular biology 2004;11(1):67-72.
2003: Rekha G Panchal; Gordon Ruthel; Tara A Kenny; George Kallstrom; Douglas Lane; Shirin S Badie; Limin Li; Sina Bavari; M Javad Aman
In vivo oligomerization and raft localization of Ebola virus protein VP40 during vesicular budding.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(26):15936-41.
2003: Kelly L Warfield; Catharine M Bosio; Brent C Welcher; Emily M Deal; Mansour Mohamadzadeh; Alan L Schmaljohn; M Javad Aman; Sina Bavari
Ebola virus-like particles protect from lethal Ebola virus infection.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(26):15889-94.
2003: Catharine M Bosio; M Javad Aman; Case Grogan; Robert Jeffrey Hogan; Gordon Ruthel; diane negley; Mansour Mohamadzadeh; Sina Bavari; Alan L Schmaljohn
Ebola and Marburg viruses replicate in monocyte-derived dendritic cells without inducing the production of cytokines and full maturation.
The Journal of infectious diseases 2003;188(11):1630-8.
2003: James C Burnett; James J Schmidt; Robert G Stafford; Rekha G Panchal; Tam L Nguyen; Ann R Hermone; Jonathan L Vennerstrom; Connor F McGrath; Douglas J Lane; Edward A Sausville; Daniel W Zaharevitz; Rick Gussio; Sina Bavari
Novel small molecule inhibitors of botulinum neurotoxin A metalloprotease activity.
Biochemical and biophysical research communications 2003;310(1):84-93.
2003: John H Carra; Brent C Welcher; Rowena D Schokman; Chella S David; Sina Bavari
Mutational effects on protein folding stability and antigenicity: the case of streptococcal pyrogenic exotoxin A.
Clinical immunology (Orlando, Fla.) 2003;108(1):60-8.
2003: James W Boles; M Louise M Pitt; Ross D LeClaire; Paul H Gibbs; Edna Torres; Beverly Dyas; Robert G Ulrich; Sina Bavari
Generation of protective immunity by inactivated recombinant staphylococcal enterotoxin B vaccine in nonhuman primates and identification of correlates of immunity.
Clinical immunology (Orlando, Fla.) 2003;108(1):51-9.
2003: James W Boles; M Louise M Pitt; Ross D LeClaire; Paul H Gibbs; Robert G Ulrich; Sina Bavari
Correlation of body temperature with protection against staphylococcal enterotoxin B exposure and use in determining vaccine dose-schedule.
Vaccine 2003;21(21-22):2791-6.
2003: M Javad Aman; Catharine M Bosio; Rekha G Panchal; James C Burnett; Alan L Schmaljohn; Sina Bavari
Molecular mechanisms of filovirus cellular trafficking.
Microbes and infection / Institut Pasteur 2003;5(7):639-49.
2002: Brent C Welcher; John H Carra; Luis DaSilva; Juli Hanson; Chella S David; M Javad Aman; Sina Bavari
Lethal shock induced by streptococcal pyrogenic exotoxin A in mice transgenic for human leukocyte antigen-DQ8 and human CD4 receptors: implications for development of vaccines and therapeutics.
The Journal of infectious diseases 2002;186(4):501-10.
2002: Luis DaSilva; Brent C Welcher; Robert G Ulrich; M Javad Aman; Chella S David; Sina Bavari
Humanlike immune response of human leukocyte antigen-DR3 transgenic mice to staphylococcal enterotoxins: a novel model for superantigen vaccines.
The Journal of infectious diseases 2002;185(12):1754-60.
2002: Ross D LeClaire; Robert E Hunt; Sina Bavari
Protection against bacterial superantigen staphylococcal enterotoxin B by passive vaccination.
Infection and immunity 2002;70(5):2278-81.
2002: Sina Bavari; Catharine M Bosio; Elizabeth Wiegand; Gordon Ruthel; Amy B Will; Thomas W Geisbert; Michael Hevey; Connie S Schmaljohn; Alan L Schmaljohn; M Javad Aman
Lipid raft microdomains: a gateway for compartmentalized trafficking of Ebola and Marburg viruses.
The Journal of experimental medicine 2002;195(5):593-602.
2002: J Daniel Coffman; Jianwei Zhu; John M Roach; Sina Bavari; Robert G Ulrich; Steven L Giardina
Production and purification of a recombinant Staphylococcal enterotoxin B vaccine candidate expressed in Escherichia coli.
Protein expression and purification 2002;24(2):302-12.
2001: J L Erwin; Luis DaSilva; Sina Bavari; Stephen F Little; Arthur M Friedlander; T C Chanh
Macrophage-derived cell lines do not express proinflammatory cytokines after exposure to Bacillus anthracis lethal toxin.
Infection and immunity 2001;69(2):1175-7.
2001: Ross D LeClaire; Sina Bavari
Human antibodies to bacterial superantigens and their ability to inhibit T-cell activation and lethality.
Antimicrobial agents and chemotherapy 2001;45(2):460-3.
2001: Dorothy D Pless; E R Torres; E K Reinke; Sina Bavari
High-affinity, protective antibodies to the binding domain of botulinum neurotoxin type A.
Infection and immunity 2001;69(1):570-4.
1999: Sina Bavari; Robert G Ulrich; Ross D LeClaire
Cross-reactive antibodies prevent the lethal effects of Staphylococcus aureus superantigens.
The Journal of infectious diseases 1999;180(4):1365-9.
1998: Robert G Ulrich; Mark A Olson; Sina Bavari
Development of engineered vaccines effective against structurally related bacterial superantigens.
Vaccine 1998;16(19):1857-64.
1998: Sina Bavari; Dorothy D Pless; E R Torres; FJ Lebeda; Mark A Olson
Identifying the principal protective antigenic determinants of type A botulinum neurotoxin.
Vaccine 1998;16(19):1850-6.
1996: R D LeClaire; R E Hunt; Sina Bavari; J E Estep; G O Nelson; C L Wilhelmsen
Potentiation of inhaled staphylococcal enterotoxin B-induced toxicity by lipopolysaccharide in mice.
Toxicologic pathology 1996;24(5):619-26.
1996: Sina Bavari; B Dyas; Robert G Ulrich
Superantigen vaccines: a comparative study of genetically attenuated receptor-binding mutants of staphylococcal enterotoxin A.
The Journal of infectious diseases 1996;174(2):338-45.
1996: R D LeClaire; W Kell; Sina Bavari; T J Smith; R E Hunt
Protective effects of niacinamide in staphylococcal enterotoxin-B-induced toxicity.
Toxicology 1996;107(1):69-81.
1995: Robert G Ulrich; Sina Bavari; Mark A Olson
Bacterial superantigens in human disease: structure, function and diversity.
Trends in microbiology 1995;3(12):463-8.
1995: Sina Bavari; R E Hunt; Robert G Ulrich
Divergence of human and nonhuman primate lymphocyte responses to bacterial superantigens.
Clinical immunology and immunopathology 1995;76(3 Pt 1):248-54.
1995: Robert G Ulrich; Sina Bavari; Mark A Olson
Staphylococcal enterotoxins A and B share a common structural motif for binding class II major histocompatibility complex molecules.
Nature structural biology 1995;2(7):554-60.
1995: Sina Bavari; Robert G Ulrich
Staphylococcal enterotoxin A and toxic shock syndrome toxin compete with CD4 for human major histocompatibility complex class II binding.
Infection and immunity 1995;63(2):423-9.
1993: Bradley G Stiles; Sina Bavari; Teresa Krakauer; Robert G Ulrich
Toxicity of staphylococcal enterotoxins potentiated by lipopolysaccharide: major histocompatibility complex class II molecule dependency and cytokine release.
Infection and immunity 1993;61(12):5333-8.