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Jukka-Pekka Mecklin

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Hannu Paajanen; Tuomo Rantanen; Tero Rautio; Markku Aarnio; Kirsti Dean; Juha M Grönroos; Saija Hurme; Airi Jartti; Jukka-Pekka Mecklin; Pia Nordström; Juhani Sand; Paulina T P Salminen
A prospective randomized controlled multicenter trial comparing antibiotic therapy with appendectomy in the treatment of uncomplicated acute appendicitis (APPAC trial).
K Kämpjärvi; Outi Kilpivaara; Heli J Lehtonen; R L Levine; N Mäkinen; Jukka-Pekka Mecklin; M Mehine; Heli Nevanlinna; L M Pelttari; H Schrewe; Lauri A Aaltonen; O Abdel-Wahab; Johanna Arola; Tom Böhling; J Böhm; Ralf Bützow; Heikki Heinonen; P Hokland; Pia Vahteristo
Somatic MED12 mutations in uterine leiomyosarcoma and colorectal cancer.
Kirsi Pylvänäinen; Heikki Järvinen; Ilmo Kellokumpu; Tuula Lehtinen; Jukka-Pekka Mecklin
Causes of death of mutation carriers in Finnish Lynch syndrome families.

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2013: Hannu Paajanen; Tuomo Rantanen; Tero Rautio; Markku Aarnio; Kirsti Dean; Juha M Grönroos; Saija Hurme; Airi Jartti; Jukka-Pekka Mecklin; Pia Nordström; Juhani Sand; Paulina T P Salminen
A prospective randomized controlled multicenter trial comparing antibiotic therapy with appendectomy in the treatment of uncomplicated acute appendicitis (APPAC trial).
BMC surgery 2013;13():3.
2012: K Kämpjärvi; Outi Kilpivaara; Heli J Lehtonen; R L Levine; N Mäkinen; Jukka-Pekka Mecklin; M Mehine; Heli Nevanlinna; L M Pelttari; H Schrewe; Lauri A Aaltonen; O Abdel-Wahab; Johanna Arola; Tom Böhling; J Böhm; Ralf Bützow; Heikki Heinonen; P Hokland; Pia Vahteristo
Somatic MED12 mutations in uterine leiomyosarcoma and colorectal cancer.
British journal of cancer 2012;107(10):1761-5.
2012: Kirsi Pylvänäinen; Heikki Järvinen; Ilmo Kellokumpu; Tuula Lehtinen; Jukka-Pekka Mecklin
Causes of death of mutation carriers in Finnish Lynch syndrome families.
Familial cancer 2012;11(3):467-71.
2012: Markku T Aarnio; Annette Gylling; Heikki J Järvinen; Matti Juhola; Päivi Peltomäki; Matti Säily; Jukka-Pekka Mecklin
Uroepithelial and kidney carcinoma in Lynch syndrome.
Familial cancer 2012;11(3):395-401.
2012: Pia Alhopuro; Diego Arango; Mia Biström; Ana M Ferreira; Sampsa Hautaniemi; Elina Heliövaara; Robert M W Hofstra; Heikki Järvinen; Auli Karhu; Heli J Lehtonen; Jukka-Pekka Mecklin; Iina Niittymäki; Kari Nousiainen; Torben F Orntoft; Jani Puhakka; Anniina Raitila; Ari Ristimäki; Juha Saharinen; Heli Sammalkorpi; Raquel Seruca; Sónia Sousa; Sari Tuupanen; Lauri A Aaltonen
Candidate driver genes in microsatellite-unstable colorectal cancer.
International journal of cancer. Journal international du cancer 2012;130(7):1558-66.
2012: Johanna E Lotsari; Jukka-Pekka Mecklin; Taina T Nieminen; Markku T Aarnio; Wael M Abdel-Rahman; Kristiina Aittomäki; Marjukka Friman; Annette Gylling; Heikki J Järvinen; Teijo Kuopio; Reino Pitkänen; Päivi Peltomäki
Breast carcinoma and Lynch syndrome: molecular analysis of tumors arising in mutation carriers, non-carriers, and sporadic cases.
Breast cancer research : BCR 2012;14(3):R90.
2011: Taina T Nieminen; Ari Ristimäki; Wael M Abdel-Rahman; Heikki J Järvinen; Päivi Lahermo; Maarit Lappalainen; Jukka-Pekka Mecklin; Päivi Peltomäki
BMPR1A mutations in hereditary nonpolyposis colorectal cancer without mismatch repair deficiency.
Gastroenterology 2011;141(1):e23-6.
2011: Iina Niittymäki; Alexandra Gylfe; Leena Laine; Marko Laakso; Heli J Lehtonen; Johanna Kondelin; Jaana Tolvanen; Kari Nousiainen; Jeroen Pouwels; Heikki Järvinen; Kyösti Nuorva; Jukka-Pekka Mecklin; Markus Makinen; Ari Ristimäki; Torben F Ørntoft; Sampsa Hautaniemi; Auli Karhu; Marko J Kallio; Lauri A Aaltonen
High frequency of TTK mutations in microsatellite-unstable colorectal cancer and evaluation of their effect on spindle assembly checkpoint.
Carcinogenesis 2011;32(3):305-11.
2011: Katja I Aktan-Collan; Helena Kääriäinen; Eeva M Kolttola; Kirsi Pylvänäinen; Heikki J Järvinen; Ari H Haukkala; Jukka-Pekka Mecklin
Sharing genetic risk with next generation: mutation-positive parents' communication with their offspring in Lynch Syndrome.
Familial cancer 2011;10(1):43-50.
2011: Iina Niittymäki; Sari Tuupanen; Yilong Li; Heikki Järvinen; Jukka-Pekka Mecklin; Ian P M Tomlinson; Richard S Houlston; Auli Karhu; Lauri A Aaltonen
Systematic search for enhancer elements and somatic allelic imbalance at seven low-penetrance colorectal cancer predisposition loci.
BMC medical genetics 2011;12():23.
2010: Alexandra E Gylfe; Johanna Sirkiä; Manuel Ahlsten; Heikki Järvinen; Jukka-Pekka Mecklin; Auli Karhu; Lauri A Aaltonen
Somatic mutations and germline sequence variants in patients with familial colorectal cancer.
International journal of cancer. Journal international du cancer 2010;127(12):2974-80.
2010: Eevi Kaasinen; Kristiina Aittomäki; Marianne Eronen; Pia Vahteristo; Auli Karhu; Jukka-Pekka Mecklin; Eero Kajantie; Lauri A Aaltonen; Rainer Lehtonen
Recessively inherited right atrial isomerism caused by mutations in growth/differentiation factor 1 (GDF1).
Human molecular genetics 2010;19(14):2747-53.
2010: Pia Alhopuro; Mikael Björklund; Heli Sammalkorpi; Mikko Turunen; Sari Tuupanen; Mia Biström; Iina Niittymäki; Heli J Lehtonen; Teemu Kivioja; Virpi Launonen; Juha Saharinen; Kari Nousiainen; Sampsa Hautaniemi; Kyösti Nuorva; Jukka-Pekka Mecklin; Heikki Järvinen; Torben F Orntoft; Diego Arango; Rainer Lehtonen; Auli Karhu; Jussi Taipale; Lauri A Aaltonen
Mutations in the circadian gene CLOCK in colorectal cancer.
Molecular cancer research : MCR 2010;8(7):952-60.
2010: Iina Niittymäki; Eevi Kaasinen; Sari Tuupanen; Auli Karhu; Heikki Järvinen; Jukka-Pekka Mecklin; Ian P M Tomlinson; Maria Chiara Di Bernardo; richard Houlston; Lauri A Aaltonen
Low-penetrance susceptibility variants in familial colorectal cancer.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2010;19(6):1478-83.
2009: Heikki J Järvinen; Laura Renkonen-Sinisalo; Katja Aktán-Collán; Päivi Peltomäki; Lauri A Aaltonen; Jukka-Pekka Mecklin
Ten years after mutation testing for Lynch syndrome: cancer incidence and outcome in mutation-positive and mutation-negative family members.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2009;27(28):4793-7.
2009: Taina T Nieminen; Annette Gylling; Wael M Abdel-Rahman; Kyösti Nuorva; Markku T Aarnio; Laura Renkonen-Sinisalo; Heikki J Järvinen; Jukka-Pekka Mecklin; Ralf Bützow; Päivi Peltomäki
Molecular analysis of endometrial tumorigenesis: importance of complex hyperplasia regardless of atypia.
Clinical cancer research : an official journal of the American Association for Cancer Research 2009;15(18):5772-83.
2009: Sari Tuupanen; Mikko Turunen; Rainer Lehtonen; Outi Hallikas; Sakari Vanharanta; Teemu Kivioja; Mikael Björklund; Gonghong Wei; Jian Yan; Iina Niittymäki; Jukka-Pekka Mecklin; Heikki Järvinen; Ari Ristimäki; Mariachiara Di-Bernardo; Phil East; Luis Carvajal Carmona; richard Houlston; Ian Tomlinson; Kimmo Palin; Esko Ukkonen; Auli Karhu; Jussi Taipale; Lauri A Aaltonen
The common colorectal cancer predisposition SNP rs6983267 at chromosome 8q24 confers potential to enhanced Wnt signaling.
Nature genetics 2009;41(8):885-90.
2009: Annette Gylling; Maaret Ridanpää; Outi Vierimaa; Kristiina Aittomäki; Kristiina Avela; Helena Kääriäinen; Hannele Laivuori; Minna Pöyhönen; Satu-Leena Sallinen; Carina Wallgren-Pettersson; Heikki J Järvinen; Jukka-Pekka Mecklin; Päivi Peltomäki
Large genomic rearrangements and germline epimutations in Lynch syndrome.
International journal of cancer. Journal international du cancer 2009;124(10):2333-40.
2008: Sanna Siltanen; Kirsi Syrjäkoski; Rainer Fagerholm; Tarja Ikonen; Peter Lipman; Jacob Mallott; Kaija Holli; Teuvo L J Tammela; Heikki J Järvinen; Jukka-Pekka Mecklin; Kristiina Aittomäki; Carl Blomqvist; Joan E Bailey-Wilson; Heli Nevanlinna; Lauri A Aaltonen; Johanna Schleutker; Pia Vahteristo
ARLTS1 germline variants and the risk for breast, prostate, and colorectal cancer.
European journal of human genetics : EJHG 2008;16(8):983-91.
2008: Patrice Watson; H F A Vasen; Jukka-Pekka Mecklin; Inge Bernstein; Markku Aarnio; Heikki J Järvinen; Torben Myrhøj; Lone Sunde; Juul Wijnen; Henry T Lynch
The risk of extra-colonic, extra-endometrial cancer in the Lynch syndrome.
International journal of cancer. Journal international du cancer 2008;123(2):444-9.
2008: A Liljegren; Gail Barker; Faye Elliott; Lucio Bertario; Marie Luise Bisgaard; Diana Eccles; Gareth Evans; Finlay Macrae; Eamonn Maher; Annika Lindblom; Samuel Rotstein; Bo Nilsson; Jukka-Pekka Mecklin; Gabriela Möslein; Jeremy Jass; Riccardo Fodde; John Mathers; John Burn; D Timothy Bishop
Prevalence of adenomas and hyperplastic polyps in mismatch repair mutation carriers among CAPP2 participants: report by the colorectal adenoma/carcinoma prevention programme 2.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2008;26(20):3434-9.
2008: A H S Gylling; T T Nieminen; Wael M Abdel-Rahman; Kyösti Nuorva; Matti Juhola; E I Joensuu; Heikki J Järvinen; Jukka-Pekka Mecklin; Markku T Aarnio; Päivi Peltomäki
Differential cancer predisposition in Lynch syndrome: insights from molecular analysis of brain and urinary tract tumors.
Carcinogenesis 2008;29(7):1351-9.
2008: Pia Alhopuro; Denis Phichith; Sari Tuupanen; Heli Sammalkorpi; Miranda Nybondas; Juha Saharinen; James P Robinson; Zhaohui Yang; Li-Qiong Chen; Torben Orntoft; Jukka-Pekka Mecklin; Heikki Järvinen; Charis Eng; Gabriela Moeslein; Darryl Shibata; richard Houlston; Anneke Lucassen; Ian P M Tomlinson; Virpi Launonen; Ari Ristimäki; Diego Arango; Auli Karhu; H Lee Sweeney; Lauri A Aaltonen
Unregulated smooth-muscle myosin in human intestinal neoplasia.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(14):5513-8.
2008: Sari Tuupanen; Iina Niittymäki; Kari Nousiainen; Sakari Vanharanta; Jukka-Pekka Mecklin; Kyösti Nuorva; Heikki Järvinen; Sampsa Hautaniemi; Auli Karhu; Lauri A Aaltonen
Allelic imbalance at rs6983267 suggests selection of the risk allele in somatic colorectal tumor evolution.
Cancer research 2008;68(1):14-7.
2007: Katja Aktan-Collan; Ari Haukkala; Kirsi Pylvänäinen; Heikki J Järvinen; Lauri A Aaltonen; Päivi Peltomäki; E Rantanen; Helena Kääriäinen; Jukka-Pekka Mecklin
Direct contact in inviting high-risk members of hereditary colon cancer families to genetic counselling and DNA testing.
Journal of medical genetics 2007;44(11):732-8.
2007: Jukka-Pekka Mecklin; Markku T Aarnio; Esa Läärä; Matti Kairaluoma; Kirsi Pylvänäinen; Päivi Peltomäki; Lauri A Aaltonen; Heikki J Järvinen
Development of colorectal tumors in colonoscopic surveillance in Lynch syndrome.
Gastroenterology 2007;133(4):1093-8.
2007: Anssi M Niemelä; Piritta Hynninen; Jukka-Pekka Mecklin; Teijo Kuopio; Antti Kokko; Lauri Aaltonen; Anna-Kaisa Parkkila; Silvia Pastorekova; Jaromir Pastorek; Abdul Waheed; William S Sly; Torben F Orntoft; Mogens Kruhøffer; Hannu Haapasalo; Seppo Parkkila; Aarre Kivelä
Carbonic anhydrase IX is highly expressed in hereditary nonpolyposis colorectal cancer.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2007;16(9):1760-6.
2007: Sari Tuupanen; Pia Alhopuro; Jukka-Pekka Mecklin; Heikki Järvinen; Lauri A Aaltonen
No evidence for association of NOD2 R702W and G908R with colorectal cancer.
International journal of cancer. Journal international du cancer 2007;121(1):76-9.
2007: A Gylling; Wael M Abdel-Rahman; Matti Juhola; Kyösti Nuorva; E Hautala; Heikki J Järvinen; Jukka-Pekka Mecklin; Markku T Aarnio; Päivi Peltomäki
Is gastric cancer part of the tumour spectrum of hereditary non-polyposis colorectal cancer? A molecular genetic study.
Gut 2007;56(7):926-33.
2007: Heli Sammalkorpi; Pia Alhopuro; Rainer Lehtonen; Jarno Tuimala; Jukka-Pekka Mecklin; Heikki J Järvinen; Josef Jiricny; Auli Karhu; Lauri A Aaltonen
Background mutation frequency in microsatellite-unstable colorectal cancer.
Cancer research 2007;67(12):5691-8.
2007: H F A Vasen; Gabriela Möslein; A Alonso; I Bernstein; L Bertario; I Blanco; John Burn; G Capella; Christoph Engel; Ian M Frayling; Waltraut Friedl; Frederik J Hes; Shirley Hodgson; Jukka-Pekka Mecklin; Pål Møller; Fokko M Nagengast; Y Parc; Laura Renkonen-Sinisalo; Julian R Sampson; Astrid T Stormorken; Juul Wijnen
Guidelines for the clinical management of Lynch syndrome (hereditary non-polyposis cancer).
Journal of medical genetics 2007;44(6):353-62.
2007: Sari Tuupanen; Auli Karhu; Heikki Järvinen; Jukka-Pekka Mecklin; Virpi Launonen; Lauri A Aaltonen
No evidence for dual role of loss of heterozygosity in hereditary non-polyposis colorectal cancer.
Oncogene 2007;26(17):2513-7.
2007: Laura Renkonen-Sinisalo; Ralf Bützow; Arto Leminen; Pentti Lehtovirta; Jukka-Pekka Mecklin; Heikki J Järvinen
Surveillance for endometrial cancer in hereditary nonpolyposis colorectal cancer syndrome.
International journal of cancer. Journal international du cancer 2007;120(4):821-4.
2007: Päivi Laiho; Antti Kokko; Sakari Vanharanta; Reijo Salovaara; Heli Sammalkorpi; Heikki Järvinen; Jukka-Pekka Mecklin; Tuomo J Karttunen; Karoliina Tuppurainen; Veronica Davalos; Simó Schwartz; Diego Arango; Markus Makinen; Lauri A Aaltonen
Serrated carcinomas form a subclass of colorectal cancer with distinct molecular basis.
Oncogene 2007;26(2):312-20.
2007: Lauri Aaltonen; Louise Johns; Heikki Järvinen; Jukka-Pekka Mecklin; richard Houlston
Explaining the familial colorectal cancer risk associated with mismatch repair (MMR)-deficient and MMR-stable tumors.
Clinical cancer research : an official journal of the American Association for Cancer Research 2007;13(1):356-61.
2006: Wael M Abdel-Rahman; Jukka-Pekka Mecklin; Päivi Peltomäki
The genetics of HNPCC: application to diagnosis and screening.
Critical reviews in oncology/hematology 2006;58(3):208-20.
2006: Tuija Hienonen; Reijo Salovaara; Jukka-Pekka Mecklin; Heikki Järvinen; Auli Karhu; Lauri A Aaltonen
Preferential amplification of AURKA 91A (Ile31) in familial colorectal cancers.
International journal of cancer. Journal international du cancer 2006;118(2):505-8.
2006: Antti Kokko; Päivi Laiho; Rainer Lehtonen; Sanna Korja; Luis Carvajal Carmona; Heikki Järvinen; Jukka-Pekka Mecklin; Charis Eng; Johanna Schleutker; Ian P M Tomlinson; Pia Vahteristo; Lauri A Aaltonen
EPHB2 germline variants in patients with colorectal cancer or hyperplastic polyposis.
BMC cancer 2006;6():145.
2006: Kirsi Pylvänäinen; Matti Kairaluoma; Jukka-Pekka Mecklin
Compliance and Satisfaction with Long-Term Surveillance in Finnish HNPCC Families.
Familial cancer 2006;5(2):175-8.
2005: Kaisa Sotamaa; Sandya Liyanarachchi; Jukka-Pekka Mecklin; Heikki Järvinen; Lauri A Aaltonen; Päivi Peltomäki; Albert de La Chapelle
p53 codon 72 and MDM2 SNP309 polymorphisms and age of colorectal cancer onset in Lynch syndrome.
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(19 Pt 1):6840-4.
2005: Pia Alhopuro; Antony R Parker; Rainer Lehtonen; Susa Enholm; Heikki J Järvinen; Jukka-Pekka Mecklin; Auli Karhu; James R Eshleman; Lauri A Aaltonen
A novel functionally deficient MYH variant in individuals with colorectal adenomatous polyposis.
Human mutation 2005;26(4):393.
2005: Pia Alhopuro; Hafid Alazzouzi; Heli Sammalkorpi; Verónica Dávalos; Reijo Salovaara; Akseli Hemminki; Heikki Järvinen; Jukka-Pekka Mecklin; Simo Schwartz; Lauri A Aaltonen; Diego Arango
SMAD4 levels and response to 5-fluorouracil in colorectal cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(17):6311-6.
2005: Diego Arango; Päivi Laiho; Antti Kokko; Pia Alhopuro; Heli Sammalkorpi; Reijo Salovaara; Daniel Nicorici; Sampsa Hautaniemi; Hafid Alazzouzi; Jukka-Pekka Mecklin; Heikki Järvinen; Akseli Hemminki; Jaakko Astola; Simo Schwartz; Lauri A Aaltonen
Gene-expression profiling predicts recurrence in Dukes' C colorectal cancer.
Gastroenterology 2005;129(3):874-84.
2005: Pia Alhopuro; Sanna K Ylisaukko-oja; Walter J Koskinen; Petri Bono; Johanna Arola; Heikki J Järvinen; Jukka-Pekka Mecklin; Timo Atula; Risto Kontio; Antti A Mäkitie; S Suominen; Ilmo Leivo; Pia Vahteristo; Leena-Maija Aaltonen; Lauri A Aaltonen
The MDM2 promoter polymorphism SNP309T-->G and the risk of uterine leiomyosarcoma, colorectal cancer, and squamous cell carcinoma of the head and neck.
Journal of medical genetics 2005;42(9):694-8.
2005: Heather Hampel; Julie A Stephens; Eero Pukkala; Risto Sankila; Lauri A Aaltonen; Jukka-Pekka Mecklin; Albert de La Chapelle
Cancer risk in hereditary nonpolyposis colorectal cancer syndrome: later age of onset.
Gastroenterology 2005;129(2):415-21.
2005: Mogens Kruhøffer; Jens Ledet Jensen; Päivi Laiho; Lars Dyrskjøt; Reijo Salovaara; Diego Arango; Karin Birkenkamp-Demtroder; Flemming Brandt Sørensen; Lise Lotte Christensen; L Buhl; Jukka-Pekka Mecklin; Heikki Järvinen; Thomas Thykjaer; Friedrik P Wikman; F Bech-Knudsen; M Juhola; Nina N Nupponen; Søren Laurberg; Claus L Andersen; Lauri A Aaltonen; Torben F Ørntoft
Gene expression signatures for colorectal cancer microsatellite status and HNPCC.
British journal of cancer 2005;92(12):2240-8.
2005: Tuija Hienonen; Heli Sammalkorpi; Susa Enholm; Pia Alhopuro; Thomas D Barber; Rainer Lehtonen; Nina N Nupponen; Heli J Lehtonen; Reijo Salovaara; Jukka-Pekka Mecklin; Heikki Järvinen; Riitta Koistinen; Diego Arango; Virpi Launonen; Bert Vogelstein; Auli Karhu; Lauri A Aaltonen
Mutations in two short noncoding mononucleotide repeats in most microsatellite-unstable colorectal cancers.
Cancer research 2005;65(11):4607-13.
2005: Heli Rasinperä; Carol Forsblom; Nabil Sabri Enattah; P Halonen; K Salo; M Victorzon; Jukka-Pekka Mecklin; Heikki Järvinen; Susa Enholm; Gabrielle Sellick; Hafid Alazzouzi; richard Houlston; J Robinson; P-H Groop; Ian Tomlinson; Simó Schwartz; Lauri A Aaltonen; Irma Järvelä
The C/C-13910 genotype of adult-type hypolactasia is associated with an increased risk of colorectal cancer in the Finnish population.
Gut 2005;54(5):643-7.
2005: Hafid Alazzouzi; Pia Alhopuro; Reijo Salovaara; Heli Sammalkorpi; Heikki Järvinen; Jukka-Pekka Mecklin; Akseli Hemminki; Simo Schwartz; Lauri A Aaltonen; Diego Arango
SMAD4 as a prognostic marker in colorectal cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(7):2606-11.
2005: Wael M Abdel-Rahman; Miina Ollikainen; Reetta Kariola; Heikki J Järvinen; Jukka-Pekka Mecklin; Minna Nyström-Lahti; Sakari Knuutila; Päivi Peltomäki
Comprehensive characterization of HNPCC-related colorectal cancers reveals striking molecular features in families with no germline mismatch repair gene mutations.
Oncogene 2005;24(9):1542-51.
2005: Peter Calabrese; Jukka-Pekka Mecklin; Heikki J Järvinen; Lauri A Aaltonen; Simon Tavaré; Darryl Shibata
Numbers of mutations to different types of colorectal cancer.
BMC cancer 2005;5():126.
2005: Jukka-Pekka Mecklin; Heikki J Järvinen
Surveillance in Lynch syndrome.
Familial cancer 2005;4(3):267-71.
2004: Pia Alhopuro; Taru Ahvenainen; Jukka-Pekka Mecklin; Matti Juhola; Heikki J Järvinen; Auli Karhu; Lauri A Aaltonen
NOD2 3020insC alone is not sufficient for colorectal cancer predisposition.
Cancer research 2004;64(20):7245-7.
2004: Elise Renkonen; Hannes Lohi; Heikki J Järvinen; Jukka-Pekka Mecklin; Päivi Peltomäki
Novel splicing associations of hereditary colon cancer related DNA mismatch repair gene mutations.
Journal of medical genetics 2004;41(7):e95.
2004: Peter Calabrese; Jen-Lan Tsao; Yasushi Yatabe; Reijo Salovaara; Jukka-Pekka Mecklin; Heikki J Järvinen; Lauri A Aaltonen; Simon Tavaré; Darryl Shibata
Colorectal pretumor progression before and after loss of DNA mismatch repair.
The American journal of pathology 2004;164(4):1447-53.
2004: Rainer Lehtonen; Maija Kiuru; Sakari Vanharanta; Jari Sjöberg; Leena-Maija Aaltonen; Kristiina Aittomäki; Johanna Arola; Ralf Butzow; Charis Eng; Kirsti Husgafvel-Pursiainen; Jorma Isola; Heikki Järvinen; Pasi A Koivisto; Jukka-Pekka Mecklin; Päivi Peltomäki; Reijo Salovaara; Veli-Matti Wasenius; Auli Karhu; Virpi Launonen; Nina N Nupponen; Lauri A Aaltonen
Biallelic inactivation of fumarate hydratase (FH) occurs in nonsyndromic uterine leiomyomas but is rare in other tumors.
The American journal of pathology 2004;164(1):17-22.
2004: Sakari Vanharanta; Mary Buchta; Sarah R McWhinney; Sanna K Virta; Mariola Peçzkowska; Carl D Morrison; Rainer Lehtonen; Andrzej Januszewicz; Heikki Järvinen; Matti Juhola; Jukka-Pekka Mecklin; Eero Pukkala; Riitta Herva; Maija Kiuru; Nina N Nupponen; Lauri A Aaltonen; Hartmut P H Neumann; Charis Eng
Early-onset renal cell carcinoma as a novel extraparaganglial component of SDHB-associated heritable paraganglioma.
American journal of human genetics 2004;74(1):153-9.
2003: Elise Renkonen; Yange Zhang; Hannes Lohi; Reijo Salovaara; Wael M Abdel-Rahman; Mef Nilbert; Kristiina Aittomaki; Heikki J Jarvinen; Jukka-Pekka Mecklin; Annika Lindblom; Paivi Peltomaki
Altered expression of MLH1, MSH2, and MSH6 in predisposition to hereditary nonpolyposis colorectal cancer.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2003;21(19):3629-37.
2003: Susa Enholm; Tuija Hienonen; Anu Suomalainen; Lara Lipton; Ian Tomlinson; Vesa Kärjä; Matti Eskelinen; Jukka-Pekka Mecklin; Auli Karhu; Heikki J Järvinen; Lauri A Aaltonen
Proportion and phenotype of MYH-associated colorectal neoplasia in a population-based series of Finnish colorectal cancer patients.
The American journal of pathology 2003;163(3):827-32.
2003: Tuija Hienonen; Päivi Laiho; Reijo Salovaara; Jukka-Pekka Mecklin; Heikki Järvinen; Pertti Sistonen; Päivi Peltomäki; Rainer Lehtonen; Nina N Nupponen; Virpi Launonen; Auli Karhu; Lauri A Aaltonen
Little evidence for involvement of MLH3 in colorectal cancer predisposition.
International journal of cancer. Journal international du cancer 2003;106(2):292-6.
2003: Päivi Laiho; Tuija Hienonen; Jukka-Pekka Mecklin; Heikki Järvinen; Auli Karhu; Virpi Launonen; Lauri A Aaltonen
Mutation and LOH analysis of ACO2 in colorectal cancer: no evidence of biallelic genetic inactivation.
Journal of medical genetics 2003;40(5):e73.
2003: Päivi Laiho; Tuija Hienonen; Auli Karhu; Lara Lipton; Yan Aalto; Huw J W Thomas; Karin Birkenkamp-Demtroder; Shirley Hodgson; Reijo Salovaara; Jukka-Pekka Mecklin; Heikki Järvinen; Sakari Knuutila; Stephanie Halford; Torben F Ørntoft; Ian Tomlinson; Virpi Launonen; richard Houlston; Lauri A Aaltonen
Genome-wide allelotyping of 104 Finnish colorectal cancers reveals an excess of allelic imbalance in chromosome 20q in familial cases.
Oncogene 2003;22(14):2206-14.
2003: Henry T Lynch; Giuseppe Cristofaro; Paul Rozen; H F A Vasen; Patrick Lynch; Jukka-Pekka Mecklin; Jim St John
History of the International Collaborative Group on Hereditary Non Polyposis Colorectal Cancer.
Familial cancer 2003;2(Suppl 1):3-5.
2003: Markku E Voutilainen; Timo Mäntynen; Ilkka Kunnamo; Matti Juhola; Jukka-Pekka Mecklin; Markus Färkkilä
Impact of clinical symptoms and referral volume on endoscopy for detecting peptic ulcer and gastric neoplasms.
Scandinavian journal of gastroenterology 2003;38(1):109-13.
2003: Shantie Jagmohan-Changur; Taija Poikonen; Susa Vilkki; Virpi Launonen; Friedrik P Wikman; Torben F Orntoft; Pål Møller; H F A Vasen; Carli Tops; Richard D Kolodner; Jukka-Pekka Mecklin; Heikki Järvinen; Stephen Bevan; richard Houlston; Lauri A Aaltonen; Riccardo Fodde; Juul Wijnen; Auli Karhu
EXO1 variants occur commonly in normal population: evidence against a role in hereditary nonpolyposis colorectal cancer.
Cancer research 2003;63(1):154-8.
2002: Timo Mäntynen; Markus Färkkilä; Ilkka Kunnamo; Jukka-Pekka Mecklin; Matti Juhola; Markku E Voutilainen
The impact of upper GI endoscopy referral volume on the diagnosis of gastroesophageal reflux disease and its complications: a 1-year cross-sectional study in a referral area with 260,000 inhabitants.
The American journal of gastroenterology 2002;97(10):2524-9.
2002: Laura Renkonen-Sinisalo; P Sipponen; Markku T Aarnio; R Julkunen; Lauri A Aaltonen; Seppo Sarna; Heikki J Järvinen; Jukka-Pekka Mecklin
No support for endoscopic surveillance for gastric cancer in hereditary non-polyposis colorectal cancer.
Scandinavian journal of gastroenterology 2002;37(5):574-7.
2002: Kyoung-Mee Kim; Reijo Salovaara; Jukka-Pekka Mecklin; Heikki J Järvinen; Lauri A Aaltonen; Darryl Shibata
PolyA deletions in hereditary nonpolyposis colorectal cancer: mutations before a gatekeeper.
The American journal of pathology 2002;160(4):1503-6.
2002: Päivi Laiho; Virpi Launonen; Päivi Lahermo; Manel Esteller; Mingzhou Guo; James G Herman; Jukka-Pekka Mecklin; Heikki Järvinen; Pertti Sistonen; Kyoung-Mee Kim; Darryl Shibata; richard Houlston; Lauri A Aaltonen
Low-level microsatellite instability in most colorectal carcinomas.
Cancer research 2002;62(4):1166-70.
2002: Ilmo Kellokumpu; Jukka-Pekka Mecklin
[Rectal cancer].
Duodecim; lääketieteellinen aikakauskirja 2002;118(8):797-804.
2002: Matti Kairaluoma; H Rissanen; V Kultti; Jukka-Pekka Mecklin; Ilmo Kellokumpu
Outcome of temporary stomas. A prospective study of temporary intestinal stomas constructed between 1989 and 1996.
Digestive surgery 2002;19(1):45-51.
2001: Katja Aktan-Collan; Ari Haukkala; Jukka-Pekka Mecklin; Antti Uutela; Helena Kääriäinen
Comprehension of cancer risk one and 12 months after predictive genetic testing for hereditary non-polyposis colorectal cancer.
Journal of medical genetics 2001;38(11):787-92.
2001: Xiao-Ping Zhou; Kelly Woodford-Richens; Rainer Lehtonen; K Kurose; Micheala A Aldred; Heather Hampel; Virpi Launonen; S Virta; Robert Pilarski; Reijo Salovaara; Walter F Bodmer; B A Conrad; M Dunlop; Shirley V Hodgson; T Iwama; Heikki Järvinen; Ilmo Kellokumpu; J C Kim; B Leggett; D Markie; Jukka-Pekka Mecklin; Kay Neale; Robin Phillips; Juan Piris; P Rozen; richard Houlston; Lauri A Aaltonen; Ian P M Tomlinson; Charis Eng
Germline mutations in BMPR1A/ALK3 cause a subset of cases of juvenile polyposis syndrome and of Cowden and Bannayan-Riley-Ruvalcaba syndromes.
American journal of human genetics 2001;69(4):704-11.
2001: Katja Aktan-Collan; Ari Haukkala; Jukka-Pekka Mecklin; Antti Uutela; Helena Kääriäinen
Psychological consequences of predictive genetic testing for hereditary non-polyposis colorectal cancer (HNPCC): a prospective follow-up study.
International journal of cancer. Journal international du cancer 2001;93(4):608-11.
2001: Patrice Watson; Ralf Bützow; Henry T Lynch; Jukka-Pekka Mecklin; Heikki J Järvinen; H F A Vasen; Lisa Madlensky; P Fidalgo; I Bernstein
The clinical features of ovarian cancer in hereditary nonpolyposis colorectal cancer.
Gynecologic oncology 2001;82(2):223-8.
2001: Kirsi Saukkonen; O Nieminen; Bastiaan P van Rees; Susa Vilkki; Matti Härkönen; M Juhola; Jukka-Pekka Mecklin; P Sipponen; Ari Ristimäki
Expression of cyclooxygenase-2 in dysplasia of the stomach and in intestinal-type gastric adenocarcinoma.
Clinical cancer research : an official journal of the American Association for Cancer Research 2001;7(7):1923-31.
2001: Anu Loukola; K Eklin; Päivi Laiho; Reijo Salovaara; Paula Kristo; Heikki Järvinen; Jukka-Pekka Mecklin; Virpi Launonen; Lauri A Aaltonen
Microsatellite marker analysis in screening for hereditary nonpolyposis colorectal cancer (HNPCC).
Cancer research 2001;61(11):4545-9.
2001: J Huang; Shannon Kuismanen; T Liu; RB Chadwick; CK Johnson; MW Stevens; S K Richards; JE Meek; X Gao; Fred A Wright; Jukka-Pekka Mecklin; H J Järvinen; H Grönberg; Marie-Luise Bisgaard; Annika Lindblom; Päivi Peltomäki
MSH6 and MSH3 are rarely involved in genetic predisposition to nonpolypotic colon cancer.
Cancer research 2001;61(4):1619-23.
2001: Päivi Peltomäki; X Gao; Jukka-Pekka Mecklin
Genotype and phenotype in hereditary nonpolyposis colon cancer: a study of families with different vs. shared predisposing mutations.
Familial cancer 2001;1(1):9-15.
2000: Akseli Hemminki; Jukka-Pekka Mecklin; Heikki Järvinen; Lauri A Aaltonen; Heikki Joensuu
Microsatellite instability is a favorable prognostic indicator in patients with colorectal cancer receiving chemotherapy.
Gastroenterology 2000;119(4):921-8.
2000: Reijo Salovaara; Anu Loukola; Paula Kristo; Helena Kääriäinen; H Ahtola; Matti Eskelinen; N Härkönen; Risto Julkunen; E Kangas; S Ojala; J Tulikoura; E Valkamo; Heikki Järvinen; Jukka-Pekka Mecklin; Lauri A Aaltonen; Albert de La Chapelle
Population-based molecular detection of hereditary nonpolyposis colorectal cancer.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2000;18(11):2193-200.
2000: Heikki J Järvinen; Markku T Aarnio; Harri Mustonen; Katja Aktan-Collan; Lauri A Aaltonen; Päivi Peltomäki; Albert de La Chapelle; Jukka-Pekka Mecklin
Controlled 15-year trial on screening for colorectal cancer in families with hereditary nonpolyposis colorectal cancer.
Gastroenterology 2000;118(5):829-34.
2000: S Roth; M Johansson; Anu Loukola; Päivi Peltomäki; Heikki Järvinen; Jukka-Pekka Mecklin; Lauri A Aaltonen
Mutation analysis of SMAD2, SMAD3, and SMAD4 genes in hereditary non-polyposis colorectal.
Journal of medical genetics 2000;37(4):298-300.
2000: Virpi Launonen; E Avizienyte; Anu Loukola; Päivi Laiho; Reijo Salovaara; Heikki Järvinen; Jukka-Pekka Mecklin; A Oku; Miyuki Shimane; H C Kim; J C Kim; Jun-ichi Nezu; Lauri A Aaltonen
No evidence of Peutz-Jeghers syndrome gene LKB1 involvement in left-sided colorectal carcinomas.
Cancer research 2000;60(3):546-8.
2000: Katja Aktan-Collan; Jukka-Pekka Mecklin; Albert de La Chapelle; Päivi Peltomäki; Antti Uutela; Helena Kääriäinen
Evaluation of a counselling protocol for predictive genetic testing for hereditary non-polyposis colorectal cancer.
Journal of medical genetics 2000;37(2):108-13.
2000: Jen-Lan Tsao; Yasushi Yatabe; Reijo Salovaara; Heikki J Järvinen; Jukka-Pekka Mecklin; Lauri A Aaltonen; Simon Tavaré; Darryl Shibata
Genetic reconstruction of individual colorectal tumor histories.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(3):1236-41.
2000: Katja Aktan-Collan; Jukka-Pekka Mecklin; Heikki Järvinen; Minna Nyström-Lahti; Päivi Peltomäki; I Söderling; Antti Uutela; Albert de La Chapelle; Helena Kääriäinen
Predictive genetic testing for hereditary non-polyposis colorectal cancer: uptake and long-term satisfaction.
International journal of cancer. Journal international du cancer 2000;89(1):44-50.
2000: Jukka-Pekka Mecklin; Päivi Peltomäki
Genetic changes associated with colon tumor development.
Annales chirurgiae et gynaecologiae 2000;89(3):211-5.
2000: Laura Renkonen-Sinisalo; Markku T Aarnio; Jukka-Pekka Mecklin; Heikki J Järvinen
Surveillance improves survival of colorectal cancer in patients with hereditary nonpolyposis colorectal cancer.
Cancer detection and prevention 2000;24(2):137-42.
2000: Markku E Voutilainen; Markus Färkkilä; Jukka-Pekka Mecklin; Matti Juhola; P Sipponen
Classical Barrett esophagus contrasted with Barrett-type epithelium at normal-appearing esophagogastric junction. Central Finland Endoscopy Study Group.
Scandinavian journal of gastroenterology 2000;35(1):2-9.
2000: Markku E Voutilainen; P Sipponen; Jukka-Pekka Mecklin; Matti Juhola; Markus Färkkilä
Gastroesophageal reflux disease: prevalence, clinical, endoscopic and histopathological findings in 1,128 consecutive patients referred for endoscopy due to dyspeptic and reflux symptoms.
Digestion 2000;61(1):6-13.
1999: Anu Loukola; Reijo Salovaara; Paula Kristo; Anu-Liisa Moisio; Helena Kääriäinen; H Ahtola; Matti Eskelinen; N Härkönen; Risto Julkunen; E Kangas; S Ojala; J Tulikoura; E Valkamo; Heikki Järvinen; Jukka-Pekka Mecklin; Albert de La Chapelle; Lauri A Aaltonen
Microsatellite instability in adenomas as a marker for hereditary nonpolyposis colorectal cancer.
The American journal of pathology 1999;155(6):1849-53.
1999: Markku E Voutilainen; Markus Färkkilä; Jukka-Pekka Mecklin; Matti Juhola; P Sipponen
Chronic inflammation at the gastroesophageal junction (carditis) appears to be a specific finding related to Helicobacter pylori infection and gastroesophageal reflux disease. The Central Finland Endoscopy Study Group.
The American journal of gastroenterology 1999;94(11):3175-80.
1999: Markku E Voutilainen; Markus Färkkilä; Matti Juhola; Jukka-Pekka Mecklin; P Sipponen
Complete and incomplete intestinal metaplasia at the oesophagogastric junction: prevalences and associations with endoscopic erosive oesophagitis and gastritis.
Gut 1999;45(5):644-8.
1999: S Roth; Pertti Sistonen; Reijo Salovaara; Akseli Hemminki; Anu Loukola; M Johansson; E Avizienyte; K A Cleary; P Lynch; C I Amos; Paula Kristo; Jukka-Pekka Mecklin; Ilmo Kellokumpu; Heikki Järvinen; Lauri A Aaltonen
SMAD genes in juvenile polyposis.
Genes, chromosomes & cancer 1999;26(1):54-61.
1999: Markku T Aarnio; Risto Sankila; Eero Pukkala; Reijo Salovaara; Lauri A Aaltonen; Albert de La Chapelle; Päivi Peltomäki; Jukka-Pekka Mecklin; Heikki J Järvinen
Cancer risk in mutation carriers of DNA-mismatch-repair genes.
International journal of cancer. Journal international du cancer 1999;81(2):214-8.
1999: Markku E Voutilainen; Markus Färkkilä; Matti Juhola; Kyösti Nuorva; K Mauranen; Timo Mäntynen; Ilkka Kunnamo; Jukka-Pekka Mecklin; P Sipponen
Specialized columnar epithelium of the esophagogastric junction: prevalence and associations. The Central Finland Endoscopy Study Group.
The American journal of gastroenterology 1999;94(4):913-8.
1999: O Nieminen; Jukka-Pekka Mecklin
[Acetylsalicylic acid and the prevention of cancer].
Duodecim; lääketieteellinen aikakauskirja 1999;115(8):849-50, 853.
1998: Anu-Liisa Moisio; Pertti Sistonen; Jukka-Pekka Mecklin; Heikki Järvinen; Päivi Peltomäki
Genetic polymorphisms in carcinogen metabolism and their association to hereditary nonpolyposis colon cancer.
Gastroenterology 1998;115(6):1387-94.
1998: Jen-Lan Tsao; J Zhang; Reijo Salovaara; Z H Li; Heikki J Järvinen; Jukka-Pekka Mecklin; Lauri A Aaltonen; Darryl Shibata
Tracing cell fates in human colorectal tumors from somatic microsatellite mutations: evidence of adenomas with stem cell architecture.
The American journal of pathology 1998;153(4):1189-200.
1998: Miguel A Rodriguez-Bigas; Hans Vasen; H T Lynch; P Watson; T Myrhøj; Heikki J Järvinen; Jukka-Pekka Mecklin; Finlay A Macrae; D James B St John; L Bertario; P Fidalgo; Lisa Madlensky; Paul Rozen
Characteristics of small bowel carcinoma in hereditary nonpolyposis colorectal carcinoma. International Collaborative Group on HNPCC.
Cancer 1998;83(2):240-4.
1998: Lauri A Aaltonen; Reijo Salovaara; Paula Kristo; F Canzian; Akseli Hemminki; Päivi Peltomäki; R B Chadwick; Helena Kääriäinen; Matti Eskelinen; Heikki Järvinen; Jukka-Pekka Mecklin; Albert de La Chapelle
Incidence of hereditary nonpolyposis colorectal cancer and the feasibility of molecular screening for the disease.
The New England journal of medicine 1998;338(21):1481-7.
1998: Markku T Aarnio; Harri Mustonen; Jukka-Pekka Mecklin; Heikki J Järvinen
Prognosis of colorectal cancer varies in different high-risk conditions.
Annals of medicine 1998;30(1):75-80.
1998: J Saltevo; K Valtola; Jukka-Pekka Mecklin; A Palmu; L Niskanen; M Laakso
[Glucose metabolism disorders following an acute alcoholic pancreatitis].
Duodecim; lääketieteellinen aikakauskirja 1998;114(11):1111-5.
1998: MT Holmberg; Paula Kristo; R B Chadwicks; Jukka-Pekka Mecklin; Heikki Järvinen; Albert de La Chapelle; Minna Nyström-Lahti; Päivi Peltomäki
Mutation sharing, predominant involvement of the MLH1 gene and description of four novel mutations in hereditary nonpolyposis colorectal cancer. Mutations in brief no. 144. Online.
Human mutation 1998;11(6):482.
1997: Markku T Aarnio; Reijo Salovaara; Lauri A Aaltonen; Jukka-Pekka Mecklin; Heikki J Järvinen
Features of gastric cancer in hereditary non-polyposis colorectal cancer syndrome.
International journal of cancer. Journal international du cancer 1997;74(5):551-5.
1997: Jukka-Pekka Mecklin
[Focusing on cancer surgery].
Duodecim; lääketieteellinen aikakauskirja 1997;113(2):93-4.
1996: Minna Nyström-Lahti; Y Wu; Anu-Liisa Moisio; Robert M W Hofstra; Jan Osinga; Jukka-Pekka Mecklin; Heikki J Järvinen; Jaakko Leisti; Charles H C M Buys; Albert de La Chapelle; Päivi Peltomäki
DNA mismatch repair gene mutations in 55 kindreds with verified or putative hereditary non-polyposis colorectal cancer.
Human molecular genetics 1996;5(6):763-9.
1996: Risto Sankila; Lauri A Aaltonen; Heikki J Järvinen; Jukka-Pekka Mecklin
Better survival rates in patients with MLH1-associated hereditary colorectal cancer.
Gastroenterology 1996;110(3):682-7.
1996: K J Hämäläinen; P Raivio; S Antila; A Palmu; Jukka-Pekka Mecklin
Biofeedback therapy in rectal prolapse patients.
Diseases of the colon and rectum 1996;39(3):262-5.
1995: Markku T Aarnio; Jukka-Pekka Mecklin; Lauri A Aaltonen; Minna Nyström-Lahti; Heikki J Järvinen
Life-time risk of different cancers in hereditary non-polyposis colorectal cancer (HNPCC) syndrome.
International journal of cancer. Journal international du cancer 1995;64(6):430-3.
1995: Minna Nyström-Lahti; Paula Kristo; N C Nicolaides; S Y Chang; Lauri A Aaltonen; Anu-Liisa Moisio; Heikki J Järvinen; Jukka-Pekka Mecklin; Kenneth W Kinzler; Bert Vogelstein
Founding mutations and Alu-mediated recombination in hereditary colon cancer.
Nature medicine 1995;1(11):1203-6.
1995: R Sumoi; T Hakala-Ala-Pietilä; Arto Leminen; Jukka-Pekka Mecklin; Pentti Lehtovirta
Hereditary aspects of endometrial adenocarcinoma.
International journal of cancer. Journal international du cancer 1995;62(2):132-7.
1995: Jukka-Pekka Mecklin; Heikki J Järvinen; A Hakkiluoto; H Hallikas; K M Hiltunen; N Härkönen; Ilmo Kellokumpu; S Laitinen; J Ovaska; J Tulikoura
Frequency of hereditary nonpolyposis colorectal cancer. A prospective multicenter study in Finland.
Diseases of the colon and rectum 1995;38(6):588-93.
1995: Heikki J Järvinen; Jukka-Pekka Mecklin; P Sistonen
Screening reduces colorectal cancer rate in families with hereditary nonpolyposis colorectal cancer.
Gastroenterology 1995;108(5):1405-11.
1995: Markku T Aarnio; Jukka-Pekka Mecklin; P Antila; A Palmu
[para-esophageal hernia--a poorly recognised form of hiatal hernia].
Duodecim; lääketieteellinen aikakauskirja 1995;111(2):149-53.
1994: Akseli Hemminki; Päivi Peltomäki; Jukka-Pekka Mecklin; Heikki Järvinen; Reijo Salovaara; Minna Nyström-Lahti; Albert de La Chapelle; Lauri A Aaltonen
Loss of the wild type MLH1 gene is a feature of hereditary nonpolyposis colorectal cancer.
Nature genetics 1994;8(4):405-10.
1994: Minna Nyström-Lahti; Pertti Sistonen; Jukka-Pekka Mecklin; Liisa Pylkkänen; Lauri A Aaltonen; Heikki Järvinen; J Weissenbach; Albert de La Chapelle; Päivi Peltomäki
Close linkage to chromosome 3p and conservation of ancestral founding haplotype in hereditary nonpolyposis colorectal cancer families.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(13):6054-8.
1994: Lauri A Aaltonen; Päivi Peltomäki; Jukka-Pekka Mecklin; Heikki Järvinen; J R Jass; J S Green; H T Lynch; P Watson; G Tallqvist; M Juhola
Replication errors in benign and malignant tumors from hereditary nonpolyposis colorectal cancer patients.
Cancer research 1994;54(7):1645-8.
1994: Lauri A Aaltonen; Risto Sankila; Jukka-Pekka Mecklin; Heikki Järvinen; Eero Pukkala; Päivi Peltomäki; Albert de La Chapelle
A novel approach to estimate the proportion of hereditary nonpolyposis colorectal cancer of total colorectal cancer burden.
Cancer detection and prevention 1994;18(1):57-63.
1993: Lauri A Aaltonen; Päivi Peltomäki; F S Leach; Pertti Sistonen; Liisa Pylkkänen; Jukka-Pekka Mecklin; Heikki Järvinen; Steven M Powell; Jin Jen; Stanley R Hamilton
Clues to the pathogenesis of familial colorectal cancer.
Science (New York, N.Y.) 1993;260(5109):812-6.
1993: Päivi Peltomäki; Lauri A Aaltonen; Pertti Sistonen; Liisa Pylkkänen; Jukka-Pekka Mecklin; Heikki Järvinen; J S Green; J R Jass; J L Weber; F S Leach
Genetic mapping of a locus predisposing to human colorectal cancer.
Science (New York, N.Y.) 1993;260(5109):810-2.
1993: Päivi Peltomäki; L Aaltonen; Jukka-Pekka Mecklin; ALBERT DE LA CHAPELLE
[A breakthrough in solving the genetic background of colon cancer].
Duodecim; lääketieteellinen aikakauskirja 1993;109(16):1367-9.
1992: Päivi Peltomäki; Pertti Sistonen; Jukka-Pekka Mecklin; Liisa Pylkkänen; Lauri A Aaltonen; S Nordling; Juha Kere; Heikki Järvinen; Stanley R Hamilton; G Petersen
Evidence that the MCC-APC gene region in 5q21 is not the site for susceptibility to hereditary nonpolyposis colorectal carcinoma.
Cancer research 1992;52(16):4530-3.
1992: Jukka-Pekka Mecklin; A Palmu; H Järvinen
[How should patients with colorectal cancer be followed?].
Duodecim; lääketieteellinen aikakauskirja 1992;108(19):1653-5.
1991: T Hakala; Jukka-Pekka Mecklin; M Forss; Heikki Järvinen; Pentti Lehtovirta
Endometrial carcinoma in the cancer family syndrome.
Cancer 1991;68(7):1656-9.
1991: Päivi Peltomäki; Pertti Sistonen; Jukka-Pekka Mecklin; Liisa Pylkkänen; Heikki Järvinen; J W Simons; Kathleen R Cho; Bert Vogelstein; Albert de La Chapelle
Evidence supporting exclusion of the DCC gene and a portion of chromosome 18q as the locus for susceptibility to hereditary nonpolyposis colorectal carcinoma in five kindreds.
Cancer research 1991;51(16):4135-40.
1991: M Kouri; Seppo Pyrhönen; Jukka-Pekka Mecklin; Heikki Järvinen; A Laasonen; Kaarle Franssila; P Kuusela; Stig Nordling
Serum carcinoembryonic antigen and DNA ploidy in colorectal carcinoma. A prospective study.
Scandinavian journal of gastroenterology 1991;26(8):812-8.
1990: M Kouri; Seppo Pyrhönen; Jukka-Pekka Mecklin; Heikki Järvinen; A Laasonen; Kaarle Franssila; Stig Nordling
The prognostic value of DNA-ploidy in colorectal carcinoma: a prospective study.
British journal of cancer 1990;62(6):976-81.
1990: Jari Ovaska; H Järvinen; Harry Kujari; I Perttilä; Jukka-Pekka Mecklin
Follow-up of patients operated on for colorectal carcinoma.
American journal of surgery 1990;159(6):593-6.
1990: M Kouri; A Laasonen; Jukka-Pekka Mecklin; Heikki Järvinen; Kaarle Franssila; Seppo Pyrhönen
Diploid predominance in hereditary nonpolyposis colorectal carcinoma evaluated by flow cytometry.
Cancer 1990;65(8):1825-9.
1989: Heikki J Järvinen; Jukka-Pekka Mecklin
Screening for hereditary colorectal carcinoma.
Scandinavian journal of gastroenterology 1989;24(10):1153-8.
1989: Jari Ovaska; Heikki J Järvinen; Jukka-Pekka Mecklin
The value of a follow-up programme after radical surgery for colorectal carcinoma.
Scandinavian journal of gastroenterology 1989;24(4):416-22.
1989: Jukka-Pekka Mecklin; Heikki J Järvinen; Jari Ovaska
Blood transfusion and prognosis in colorectal carcinoma.
Scandinavian journal of gastroenterology 1989;24(1):33-9.
1989: M Kouri; Seppo Pyrhönen; L Kangas; A Laasonen; Kaarle Franssila; Jukka-Pekka Mecklin; M J Turunen; M Lempinen
Growth of human colorectal carcinoma implants in the mouse subrenal capsule assay.
Annales chirurgiae et gynaecologiae 1989;78(2):110-4.
1989: Jukka-Pekka Mecklin; H J Järvinen; J Ovaska
[Blood transfusion and prognosis of colorectal canmcer].
Duodecim; lääketieteellinen aikakauskirja 1989;105(19):1602-6.
1988: Jukka-Pekka Mecklin; Stig Nordling; I Saario
Carcinoma of the stomach and its heredity in young patients.
Scandinavian journal of gastroenterology 1988;23(3):307-11.
1988: Heikki J Järvinen; Jari Ovaska; Jukka-Pekka Mecklin
Improvements in the treatment and prognosis of colorectal carcinoma.
The British journal of surgery 1988;75(1):25-7.
1988: J Ovaska; Jukka-Pekka Mecklin; H Järvinen
[Prognosis and follow-up of colon and rectal carcinoma patients after surgical intervention].
Duodecim; lääketieteellinen aikakauskirja 1988;104(16):1241-6.
1987: Jukka-Pekka Mecklin
Frequency of hereditary colorectal carcinoma.
Gastroenterology 1987;93(5):1021-5.