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René Medema

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Petra Kleiblova; Jiri Bartek; Jan Benada; Pavel Dundr; Jan Evcík; Zdenek Kleibl; René H Medema; Sona Pechácková; Petr Pohlreich; Indra A Shaltiel; Emile E Voest; Libor Macurek
Gain-of-function mutations of PPM1D/Wip1 impair the p53-dependent G1 checkpoint.
Jonne A Raaijmakers; Marvin E Tanenbaum; René H Medema
Systematic dissection of dynein regulators in mitosis.
Aniek Janssen; René H Medema
Cancer: Stress mixes chromosomes.

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2013: Petra Kleiblova; Jiri Bartek; Jan Benada; Pavel Dundr; Jan Evcík; Zdenek Kleibl; René H Medema; Sona Pechácková; Petr Pohlreich; Indra A Shaltiel; Emile E Voest; Libor Macurek
Gain-of-function mutations of PPM1D/Wip1 impair the p53-dependent G1 checkpoint.
The Journal of cell biology 2013;201(4):511-21.
2013: Jonne A Raaijmakers; Marvin E Tanenbaum; René H Medema
Systematic dissection of dynein regulators in mitosis.
The Journal of cell biology 2013;201(2):201-15.
2013: Aniek Janssen; René H Medema
Cancer: Stress mixes chromosomes.
Nature 2013;494(7438):439-41.
2013: Libor Macurek; René H Medema; Erik Müllers; Sona Pecháčková; Jan Benada; Kamila Burdová; Vincentius A Halim; Zdeněk Hodný; Kateřina Krejčíková; Arne Lindqvist; Jiri Bartek
Downregulation of Wip1 phosphatase modulates the cellular threshold of DNA damage signaling in mitosis.
Cell cycle (Georgetown, Tex.) 2013;12(2):251-62.
2013: Vincentius A Halim; Albert J R Heck; Monica Alvarez-Fernandez; Melinda Aprelia; shabaz mohammed; Henk W P van den Toorn; Yan Juan Xu; René H Medema
Comparative phosphoproteomic analysis of checkpoint recovery identifies new regulators of the DNA damage response.
Science signaling 2013;6(272):rs9.
2013: Mónica Alvarez-Fernández; René H Medema
Novel functions of FoxM1: from molecular mechanisms to cancer therapy.
Frontiers in oncology 2013;3():30.
2012: Wytse Bruinsma; Jonne A Raaijmakers; René H Medema
Switching Polo-like kinase-1 on and off in time and space.
Trends in biochemical sciences 2012;37(12):534-42.
2012: Jonne A Raaijmakers; Roy G H P van Heesbeen; Belen Fernandez-Garcia; Erica F Geers; Johnathan L Meaders; René H Medema; Marvin Tanenbaum
Nuclear envelope-associated dynein drives prophase centrosome separation and enables Eg5-independent bipolar spindle formation.
The EMBO journal 2012;31(21):4179-90.
2012: Katja Höpker; Safiya Khurshid; Tülay Kisner; Peter Kurschat; Tobias Lamkemeyer; Max C Liebau; Drew Lowery; René H Medema; Roman Ulrich Müller; H Christian Reinhardt; Ulrike Resch; Frederik Roels; Fabian Röther; Bernhard Schermer; Katharina Schilberg; Björn Schumacher; Tamina Seeger-Nukpezah; Martin L Sos; Roman K Thomas; Michael B Yaffe; Shuhua Chen; Francesca Fabretti; Matthias Fischer; Matthias Gaestel; Henning Hagmann; Pia Hasskamp; Lukas Heukamp; Malte P Bartram; Thomas Benzing
AATF/Che-1 acts as a phosphorylation-dependent molecular modulator to repress p53-driven apoptosis.
The EMBO journal 2012;31(20):3961-75.
2012: Maike S van der Waal; Mathijs Vleugel; Martijn J M Vromans; Claudia Wurzenberger; Daniel W Gerlich; Geert J P L Kops; René H Medema; Adrian T Saurin; Susanne M A Lens
Mps1 promotes rapid centromere accumulation of Aurora B.
EMBO reports 2012;13(9):847-54.
2012: René H Medema; L Macůrek
Checkpoint control and cancer.
Oncogene 2012;31(21):2601-13.
2012: Jennifer A Fairley; Niall S Kenneth; René H Medema; Louise E Mitchell; Erich A Nigg; Herman H W Silljé; Conrad von Schubert; Tracy Berg; Robert J White
Direct regulation of tRNA and 5S rRNA gene transcription by Polo-like kinase 1.
Molecular cell 2012;45(4):541-52.
2011: Marvin Tanenbaum; René H Medema
Localized Aurora B activity spatially controls non-kinetochore microtubules during spindle assembly.
Chromosoma 2011;120(6):599-607.
2011: René H Medema; Arne Lindqvist
Boosting and suppressing mitotic phosphorylation.
Trends in biochemical sciences 2011;36(11):578-84.
2011: Nu Zhang; Wen-Tai Chiu; Howard Colman; Aihua Gong; Xi He; He Huang; Hsueh-Te Lee; Mingguang Liu; René H Medema; Raymond Sawaya; Yong Wang; Ping Wei; Keping Xie; Jianfei Xue; W K Alfred Yung; Suyun Huang
FoxM1 promotes β-catenin nuclear localization and controls Wnt target-gene expression and glioma tumorigenesis.
Cancer cell 2011;20(4):427-42.
2011: René H Medema; Chia-Chi Lin; James Chih-Hsin Yang
Polo-like kinase 1 inhibitors and their potential role in anticancer therapy, with a focus on NSCLC.
Clinical cancer research : an official journal of the American Association for Cancer Research 2011;17(20):6459-66.
2011: Aniek Janssen; Geert J P L Kops; Karoly Szuhai; Marja van der Burg; René H Medema
Chromosome segregation errors as a cause of DNA damage and structural chromosome aberrations.
Science (New York, N.Y.) 2011;333(6051):1895-8.
2011: Monica Alvarez-Fernandez; Melinda Aprelia; Vincentius A Halim; shabaz mohammed; Jamila Laoukili; René H Medema
Protein phosphatase 2A (B55α) prevents premature activation of forkhead transcription factor FoxM1 by antagonizing cyclin A/cyclin-dependent kinase-mediated phosphorylation.
The Journal of biological chemistry 2011;286(38):33029-36.
2011: Jeanine M L Roodhart; Henk S Schipper; Edwin C A Stigter; Miranda van Amersfoort; Joost S P Vermaat; Marieke J G Backer; Jos H Beijnen; Arjan B Brenkman; Laura G M Daenen; Patrick W B Derksen; Johan Gerrits; Marije G Gerritsen; Julia M Houthuijzen; Kenji Ishihara; Eric Kalkhoven; Anton C Martens; René H Medema; Petra Moerer; Henk-Jan Prins; Emile E Voest
Mesenchymal stem cells induce resistance to chemotherapy through the release of platinum-induced fatty acids.
Cancer cell 2011;20(3):370-83.
2011: Marvin Tanenbaum; Babet van der Vaart; Anna Akhmanova; Matilde Galli; Libor Macurek; René H Medema
A complex of Kif18b and MCAK promotes microtubule depolymerization and is negatively regulated by Aurora kinases.
Current biology : CB 2011;21(16):1356-65.
2011: Raquel Domínguez-Kelly; Michelle Debatisse; Stephane Koundrioukoff; Yusé Martín; René H Medema; Veronique A J Smits; Marvin E Tanenbaum; Raimundo Freire
Wee1 controls genomic stability during replication by regulating the Mus81-Eme1 endonuclease.
The Journal of cell biology 2011;194(4):567-79.
2011: A Janssen; René H Medema
Mitosis as an anti-cancer target.
Oncogene 2011;30(25):2799-809.
2011: Aniek Janssen; René H Medema
Entosis: aneuploidy by invasion.
Nature cell biology 2011;13(3):199-201.
2011: René H Medema; Libor Macurek
Checkpoint recovery in cells: how a molecular understanding can help in the fight against cancer.
F1000 biology reports 2011;3():10.
2011: Adrian T Saurin; Maike S van der Waal; René H Medema; Susanne M A Lens; Geert J P L Kops
Aurora B potentiates Mps1 activation to ensure rapid checkpoint establishment at the onset of mitosis.
Nature communications 2011;2():316.
2011: Marvin Tanenbaum; Anna Akhmanova; René H Medema
Bi-directional transport of the nucleus by dynein and kinesin-1.
Communicative & integrative biology 2011;4(1):21-5.
2010: Marvin Tanenbaum; René H Medema
Mechanisms of centrosome separation and bipolar spindle assembly.
Developmental cell 2010;19(6):797-806.
2010: Susanne M A Lens; Emile E Voest; René H Medema
Shared and separate functions of polo-like kinases and aurora kinases in cancer.
Nature reviews. Cancer 2010;10(12):825-41.
2010: René H Medema
Greatwall in control of recovery.
Cell cycle (Georgetown, Tex.) 2010;9(21):4264-5.
2010: Marvin Tanenbaum; Anna Akhmanova; René H Medema
Dynein at the nuclear envelope.
EMBO reports 2010;11(9):649.
2010: Wouter van Zon; Janneke Ogink; Bas ter Riet; René H Medema; Hein te Riele; Rob M F Wolthuis
The APC/C recruits cyclin B1-Cdk1-Cks in prometaphase before D box recognition to control mitotic exit.
The Journal of cell biology 2010;190(4):587-602.
2010: Monica Alvarez-Fernandez; René H Medema
A new role for Cdks in the DNA damage response.
Cell cycle (Georgetown, Tex.) 2010;9(15):2915-6.
2010: Mónica Alvarez-Fernández; René H Medema; Arne Lindqvist
Transcriptional regulation underlying recovery from a DNA damage-induced arrest.
Transcription 2010;1(1):32-5.
2010: René H Medema; Marja Jäättelä
Cytosolic FoxO1: alive and killing.
Nature cell biology 2010;12(7):642-3.
2010: Monica Alvarez-Fernandez; Vincentius A Halim; Lenno Krenning; Melinda Aprelia; shabaz mohammed; Albert J Heck; René H Medema
Recovery from a DNA-damage-induced G2 arrest requires Cdk-dependent activation of FoxM1.
EMBO reports 2010;11(6):452-8.
2010: L Macůrek; Arne Lindqvist; O Voets; J Kool; H R Vos; René H Medema
Wip1 phosphatase is associated with chromatin and dephosphorylates gammaH2AX to promote checkpoint inhibition.
Oncogene 2010;29(15):2281-91.
2010: Daniël Splinter; Marvin Tanenbaum; Arne Lindqvist; Dick Jaarsma; Annette Flotho; Ka Lou Yu; Ilya Grigoriev; Dieuwke Engelsma; Elize D Haasdijk; Nanda Keijzer; Jeroen A A Demmers; Maarten Fornerod; Frauke Melchior; Casper C Hoogenraad; René H Medema; Anna Akhmanova
Bicaudal D2, dynein, and kinesin-1 associate with nuclear pore complexes and regulate centrosome and nuclear positioning during mitotic entry.
PLoS biology 2010;8(4):e1000350.
2009: V De Marco; P J Gillespie; A Li; N Karantzelis; Evangelos Christodoulou; Rob Klompmaker; S van Gerwen; A Fish; M V Petoukhov; Maria Stefanou Iliou; Z Lygerou; René H Medema; J J Blow; D I Svergun; S Taraviras; Anastassis Perraks
Quaternary structure of the human Cdt1-Geminin complex regulates DNA replication licensing.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(47):19807-12.
2009: Aniek Janssen; Geert J P L Kops; René H Medema
Elevating the frequency of chromosome mis-segregation as a strategy to kill tumor cells.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(45):19108-13.
2009: Marvin Tanenbaum; Libor Macůrek; Aniek Janssen; Erica F Geers; Monica Alvarez-Fernandez; René H Medema
Kif15 cooperates with eg5 to promote bipolar spindle assembly.
Current biology : CB 2009;19(20):1703-11.
2009: Arne Lindqvist; Menno de Bruijn; Libor Macurek; Alexandra Brás; Anneloes Mensinga; Wytse Bruinsma; Olaf Voets; Onno Kranenburg; René H Medema
Wip1 confers G2 checkpoint recovery competence by counteracting p53-dependent transcriptional repression.
The EMBO journal 2009;28(20):3196-206.
2009: Conly L Rieder; René H Medema
No way out for tumor cells.
Cancer cell 2009;16(4):274-5.
2009: Jonne A Raaijmakers; Marvin Tanenbaum; Andre Maia; René H Medema
RAMA1 is a novel kinetochore protein involved in kinetochore-microtubule attachment.
Journal of cell science 2009;122(Pt 14):2436-45.
2009: Libor Macurek; Arne Lindqvist; René H Medema
Aurora-A and hBora join the game of Polo.
Cancer research 2009;69(11):4555-8.
2009: Arne Lindqvist; Verónica Rodríguez-Bravo; René H Medema
The decision to enter mitosis: feedback and redundancy in the mitotic entry network.
The Journal of cell biology 2009;185(2):193-202.
2009: Renske van Leuken; Linda Clijsters; Wouter van Zon; Dan Lim; Xuebiao Yao; Rob M F Wolthuis; Michael B Yaffe; René H Medema; Marcel A T M van Vugt
Polo-like kinase-1 controls Aurora A destruction by activating APC/C-Cdh1.
PloS one 2009;4(4):e5282.
2009: René H Medema
Relaying the checkpoint signal from kinetochore to APC/C.
Developmental cell 2009;16(1):6-8.
2008: Libor Macůrek; Arne Lindqvist; Dan Lim; Michael A Lampson; Rob Klompmaker; Raimundo Freire; Christophe Clouin; Stephen S Taylor; Michael B Yaffe; René H Medema
Polo-like kinase-1 is activated by aurora A to promote checkpoint recovery.
Nature 2008;455(7209):119-23.
2008: René H Medema
The chromosome shuffle.
Biochimica et biophysica acta 2008;1786(1):1-3.
2008: Jamila Laoukili; Monica Alvarez-Fernandez; Marie Stahl; René H Medema
FoxM1 is degraded at mitotic exit in a Cdh1-dependent manner.
Cell cycle (Georgetown, Tex.) 2008;7(17):2720-6.
2008: Renske J van Leuken; Mark P Luna-Vargas; Titia K Sixma; Rob M F Wolthuis; René H Medema
Usp39 is essential for mitotic spindle checkpoint integrity and controls mRNA-levels of aurora B.
Cell cycle (Georgetown, Tex.) 2008;7(17):2710-9.
2008: Barbara C M van de Weerdt; Dene R Littler; Rob Klompmaker; Angelina Huseinovic; Alex Fish; Anastassis Perraks; René H Medema
Polo-box domains confer target specificity to the Polo-like kinase family.
Biochimica et biophysica acta 2008;1783(6):1015-22.
2008: Rob M F Wolthuis; Lori Clay-Farrace; Wouter van Zon; Mona Yekezare; Lars Koop; Janneke Ogink; René H Medema; Jonathon Pines
Cdc20 and Cks direct the spindle checkpoint-independent destruction of cyclin A.
Molecular cell 2008;30(3):290-302.
2008: Jamila Laoukili; Monica Alvarez-Fernandez; Lars A T Meijer; Marie Stahl; shabaz mohammed; Livio Kleij; Albert J R Heck; René H Medema
Activation of FoxM1 during G2 requires cyclin A/Cdk-dependent relief of autorepression by the FoxM1 N-terminal domain.
Molecular and cellular biology 2008;28(9):3076-87.
2008: Nannette Jelluma; Arjan B Brenkman; Niels J F van den Broek; Carin W A Cruijsen; Maria H J van Osch; Susanne M A Lens; René H Medema; Geert J P L Kops
Mps1 phosphorylates Borealin to control Aurora B activity and chromosome alignment.
Cell 2008;132(2):233-46.
2008: Nannette Jelluma; Arjan B Brenkman; Ian McLeod; John R Yates; Don W Cleveland; René H Medema; Geert J P L Kops
Chromosomal instability by inefficient Mps1 auto-activation due to a weakened mitotic checkpoint and lagging chromosomes.
PloS one 2008;3(6):e2415.
2007: Ulrich Schüller; Qing Zhao; Susana Godinho; Vivi M Heine; René H Medema; David Pellman; David H Rowitch
Forkhead transcription factor FoxM1 regulates mitotic entry and prevents spindle defects in cerebellar granule neuron precursors.
Molecular and cellular biology 2007;27(23):8259-70.
2007: Gerben Vader; Carin W A Cruijsen; Tanja van Harn; Martijn J M Vromans; René H Medema; Susanne M A Lens
The chromosomal passenger complex controls spindle checkpoint function independent from its role in correcting microtubule kinetochore interactions.
Molecular biology of the cell 2007;18(11):4553-64.
2007: René H Medema; Boudewijn M T Burgering
The X factor: skewing X inactivation towards cancer.
Cell 2007;129(7):1253-4.
2007: Sally P Wheatley; Rachel M Barrett; Paul D Andrews; René H Medema; Simon J Morley; Jason R Swedlow; Susanne M A Lens
Phosphorylation by aurora-B negatively regulates survivin function during mitosis.
Cell cycle (Georgetown, Tex.) 2007;6(10):1220-30.
2007: Taija M Kiviharju-af Hällström; Sari Jäämaa; Mia Mönkkönen; Karita Peltonen; Leif C Andersson; René H Medema; Donna M Peehl; Marikki Laiho
Human prostate epithelium lacks Wee1A-mediated DNA damage-induced checkpoint enforcement.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(17):7211-6.
2007: Jamila Laoukili; Marie Stahl; René H Medema
FoxM1: at the crossroads of ageing and cancer.
Biochimica et biophysica acta 2007;1775(1):92-102.
2006: Raimundo Freire; Marcel A T M van Vugt; Ivan Mamely; René H Medema
Claspin: timing the cell cycle arrest when the genome is damaged.
Cell cycle (Georgetown, Tex.) 2006;5(24):2831-4.
2006: Susanne M A Lens; Gerben Vader; René H Medema
The case for Survivin as mitotic regulator.
Current opinion in cell biology 2006;18(6):616-22.
2006: Ivan Mamely; Marcel A T M van Vugt; Veronique A J Smits; Jennifer I Semple; Bennie Lemmens; Anastassis Perraks; René H Medema; Raimundo Freire
Polo-like kinase-1 controls proteasome-dependent degradation of Claspin during checkpoint recovery.
Current biology : CB 2006;16(19):1950-5.
2006: Jose A Rodriguez; Susanne M A Lens; Simone W Span; Gerben Vader; René H Medema; Frank A E Kruyt; Giuseppe Giaccone
Subcellular localization and nucleocytoplasmic transport of the chromosomal passenger proteins before nuclear envelope breakdown.
Oncogene 2006;25(35):4867-79.
2006: Gerben Vader; René H Medema; Susanne M A Lens
The chromosomal passenger complex: guiding Aurora-B through mitosis.
The Journal of cell biology 2006;173(6):833-7.
2006: Barbara C M van de Weerdt; René H Medema
Polo-like kinases: a team in control of the division.
Cell cycle (Georgetown, Tex.) 2006;5(8):853-64.
2006: Susanne M A Lens; Jose A Rodriguez; Gerben Vader; Simone W Span; Giuseppe Giaccone; René H Medema
Uncoupling the central spindle-associated function of the chromosomal passenger complex from its role at centromeres.
Molecular biology of the cell 2006;17(4):1897-909.
2006: Marvin Tanenbaum; Niels Galjart; Marcel A T M van Vugt; René H Medema
CLIP-170 facilitates the formation of kinetochore-microtubule attachments.
The EMBO journal 2006;25(1):45-57.
2006: Marc Schmidt; René H Medema
Exploiting the compromised spindle assembly checkpoint function of tumor cells: dawn on the horizon?
Cell cycle (Georgetown, Tex.) 2006;5(2):159-63.
2006: Gerben Vader; Jos J W Kauw; René H Medema; Susanne M A Lens
Survivin mediates targeting of the chromosomal passenger complex to the centromere and midbody.
EMBO reports 2006;7(1):85-92.
2005: Floris Foijer; Rob M F Wolthuis; Valerie D Doodeman; René H Medema; Hein te Riele
Mitogen requirement for cell cycle progression in the absence of pocket protein activity.
Cancer cell 2005;8(6):455-66.
2005: Anna Akhmanova; Anne-Laure Mausset-Bonnefont; Wiggert A van Cappellen; Nanda Keijzer; Casper C Hoogenraad; Tatiana Stepanova; Ksenija Drabek; Jacqueline van der Wees; Mieke Mommaas; Jos J M Onderwater; Hans van der Meulen; Marvin Tanenbaum; René H Medema; Jos W Hoogerbrugge; Jan Vreeburg; Evert-Jan Uringa; J Anton Grootegoed; Frank Grosveld; Niels Galjart
The microtubule plus-end-tracking protein CLIP-170 associates with the spermatid manchette and is essential for spermatogenesis.
Genes & development 2005;19(20):2501-15.
2005: Marc Schmidt; Yemima Budirahardja; Rob Klompmaker; René H Medema
Ablation of the spindle assembly checkpoint by a compound targeting Mps1.
EMBO reports 2005;6(9):866-72.
2005: Marcel A T M van Vugt; Alexandra Bràs; René H Medema
Restarting the cell cycle when the checkpoint comes to a halt.
Cancer research 2005;65(16):7037-40.
2005: Marcel A T M van Vugt; René H Medema
Getting in and out of mitosis with Polo-like kinase-1.
Oncogene 2005;24(17):2844-59.
2005: Abdelkader Essafi; Silvia Fernández de Mattos; Yasmin A M Hassen; Inês Soeiro; Ghulam J Mufti; N Shaun B Thomas; René H Medema; Eric W-F Lam
Direct transcriptional regulation of Bim by FoxO3a mediates STI571-induced apoptosis in Bcr-Abl-expressing cells.
Oncogene 2005;24(14):2317-29.
2005: H Bea Kuiperij; Armando van der Horst; Jan A M Raaijmakers; Sanne Weijzen; René H Medema; Johannes L Bos; Boudewijn M T Burgering; Fried J T Zwartkruis
Activation of FoxO transcription factors contributes to the antiproliferative effect of cAMP.
Oncogene 2005;24(12):2087-95.
2005: Barbara C M van de Weerdt; Marcel A T M van Vugt; Catherine Lindon; Jos J W Kauw; Marieke J Rozendaal; Rob Klompmaker; Rob M F Wolthuis; René H Medema
Uncoupling anaphase-promoting complex/cyclosome activity from spindle assembly checkpoint control by deregulating polo-like kinase 1.
Molecular and cellular biology 2005;25(5):2031-44.
2005: Jamila Laoukili; Matthijs R H Kooistra; Alexandra Brás; Jos J W Kauw; Ron Kerkhoven; Ashby Morrison; Hans Clevers; René H Medema
FoxM1 is required for execution of the mitotic programme and chromosome stability.
Nature cell biology 2005;7(2):126-36.
2005: Marcel A T M van Vugt; René H Medema
Polo-like kinase-1: activity measurement and RNAi-mediated knockdown.
Methods in molecular biology (Clifton, N.J.) 2005;296():355-69.
2004: Marcel A T M van Vugt; René H Medema
Checkpoint adaptation and recovery: back with Polo after the break.
Cell cycle (Georgetown, Tex.) 2004;3(11):1383-6.
2004: Marcel A T M van Vugt; Alexandra Brás; René H Medema
Polo-like kinase-1 controls recovery from a G2 DNA damage-induced arrest in mammalian cells.
Molecular cell 2004;15(5):799-811.
2004: Marcel A T M van Vugt; Barbara C M van de Weerdt; Gerben Vader; Hans Janssen; Jero Calafat; Rob Klompmaker; Rob M F Wolthuis; René H Medema
Polo-like kinase-1 is required for bipolar spindle formation but is dispensable for anaphase promoting complex/Cdc20 activation and initiation of cytokinesis.
The Journal of biological chemistry 2004;279(35):36841-54.
2004: Caroline Bouchard; Judith Marquardt; Alexandra Brás; René H Medema; Martin Eilers
Myc-induced proliferation and transformation require Akt-mediated phosphorylation of FoxO proteins.
The EMBO journal 2004;23(14):2830-40.
2004: Armando van der Horst; Leon Tertoolen; Lydia M M de Vries-Smits; Roy A Frye; René H Medema; Boudewijn M T Burgering
FOXO4 is acetylated upon peroxide stress and deacetylated by the longevity protein hSir2(SIRT1).
The Journal of biological chemistry 2004;279(28):28873-9.
2004: René H Medema
Optimizing RNA interference for application in mammalian cells.
The Biochemical journal 2004;380(Pt 3):593-603.
2003: Andrew Sunters; Silvia Fernández de Mattos; Marie Stahl; Jan J Brosens; Georgia Zoumpoulidou; Catherine A Saunders; Paul J Coffer; René H Medema; R Charles Coombes; Eric W-F Lam
FoxO3a transcriptional regulation of Bim controls apoptosis in paclitaxel-treated breast cancer cell lines.
The Journal of biological chemistry 2003;278(50):49795-805.
2003: Susanne M A Lens; René H Medema
The survivin/Aurora B complex: its role in coordinating tension and attachment.
Cell cycle (Georgetown, Tex.) 2003;2(6):507-10.
2003: Susanne M A Lens; Rob M F Wolthuis; Rob Klompmaker; Jos J W Kauw; Reuven Agami; Thijn R Brummelkamp; Geert J P L Kops; René H Medema
Survivin is required for a sustained spindle checkpoint arrest in response to lack of tension.
The EMBO journal 2003;22(12):2934-47.
2003: Boudewijn M T Burgering; René H Medema
Decisions on life and death: FOXO Forkhead transcription factors are in command when PKB/Akt is off duty.
Journal of leukocyte biology 2003;73(6):689-701.
2002: Marc Schmidt; Silvia Fernandez de Mattos; Armando van der Horst; Rob Klompmaker; Geert J P L Kops; Eric W-F Lam; Boudewijn M T Burgering; René H Medema
Cell cycle inhibition by FoxO forkhead transcription factors involves downregulation of cyclin D.
Molecular and cellular biology 2002;22(22):7842-52.
2002: Geert J P L Kops; Tobias B Dansen; Paulien E Polderman; Ingrid Saarloos; Karel W A Wirtz; Paul J Coffer; Ting-T Huang; Johannes L Bos; René H Medema; Boudewijn M T Burgering
Forkhead transcription factor FOXO3a protects quiescent cells from oxidative stress.
Nature 2002;419(6904):316-21.
2002: Wendelina J M Mackus; Susanne M A Lens; René H Medema; Mark J Kwakkenbos; Ludo M Evers; Marinus H J van Oers; René A W van Lier; Eric Eldering
Prevention of B cell antigen receptor-induced apoptosis by ligation of CD40 occurs downstream of cell cycle regulation.
International immunology 2002;14(9):973-82.
2002: Jan Paul Medema; René H Medema
Chromosome instability: lessons from HIV.
Nature cell biology 2002;4(8):E191-3.
2002: Marie Stahl; Pascale F Dijkers; Geert J P L Kops; Susanne M A Lens; Paul J Coffer; Boudewijn M T Burgering; René H Medema
The forkhead transcription factor FoxO regulates transcription of p27Kip1 and Bim in response to IL-2.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(10):5024-31.
2002: Karin Barnouin; Marlène L Dubuisson; Emma S Child; Silvia Fernandez de Mattos; Janet Glassford; René H Medema; David J Mann; Eric W-F Lam
H2O2 induces a transient multi-phase cell cycle arrest in mouse fibroblasts through modulating cyclin D and p21Cip1 expression.
The Journal of biological chemistry 2002;277(16):13761-70.
2002: Geert J P L Kops; René H Medema; Janet Glassford; Marieke A G Essers; Pascale F Dijkers; Paul J Coffer; Eric W-F Lam; Boudewijn M T Burgering
Control of cell cycle exit and entry by protein kinase B-regulated forkhead transcription factors.
Molecular and cellular biology 2002;22(7):2025-36.
2001: Marcel A T M van Vugt; Veronique A J Smits; Rob Klompmaker; René H Medema
Inhibition of Polo-like kinase-1 by DNA damage occurs in an ATM- or ATR-dependent fashion.
The Journal of biological chemistry 2001;276(45):41656-60.
2001: Brigitte A van Oirschot; M Stahl; Susanne M A Lens; René H Medema
Protein kinase A regulates expression of p27(kip1) and cyclin D3 to suppress proliferation of leukemic T cell lines.
The Journal of biological chemistry 2001;276(36):33854-60.
2001: Veronique A J Smits; René H Medema
Checking out the G(2)/M transition.
Biochimica et biophysica acta 2001;1519(1-2):1-12.
2000: Pascale F Dijkers; René H Medema; CM Pals; Lolita Banerji; N Shaun B Thomas; Eric W-F Lam; Boudewijn M T Burgering; Jan A M Raaijmakers; Jan-Willem J Lammers; Leo Koenderman; Paul J Coffer
Forkhead transcription factor FKHR-L1 modulates cytokine-dependent transcriptional regulation of p27(KIP1).
Molecular and cellular biology 2000;20(24):9138-48.
2000: Pascale F Dijkers; René H Medema; Jan-Willem J Lammers; Leo Koenderman; Paul J Coffer
Expression of the pro-apoptotic Bcl-2 family member Bim is regulated by the forkhead transcription factor FKHR-L1.
Current biology : CB 2000;10(19):1201-4.
2000: Veronique A J Smits; Rob Klompmaker; T Vallenius; Gert Rijksen; T P Mäkela; René H Medema
p21 inhibits Thr161 phosphorylation of Cdc2 to enforce the G2 DNA damage checkpoint.
The Journal of biological chemistry 2000;275(39):30638-43.
2000: Veronique A J Smits; Rob Klompmaker; L Arnaud; Gert Rijksen; E A Nigg; René H Medema
Polo-like kinase-1 is a target of the DNA damage checkpoint.
Nature cell biology 2000;2(9):672-6.
2000: Manuel Collado; René H Medema; Isabel Garcia-Cao; M L Dubuisson; Marta Barradas; Janet Glassford; C Rivas; Boudewijn M T Burgering; Manuel Serrano; Eric W-F Lam
Inhibition of the phosphoinositide 3-kinase pathway induces a senescence-like arrest mediated by p27Kip1.
The Journal of biological chemistry 2000;275(29):21960-8.
2000: Veronique A J Smits; M A van Peer; Marieke A G Essers; Rob Klompmaker; Gert Rijksen; René H Medema
Negative growth regulation of SK-N-MC cells by bFGF defines a growth factor-sensitive point in G2.
The Journal of biological chemistry 2000;275(25):19375-81.
2000: René H Medema; Geert J P L Kops; Johannes L Bos; Boudewijn M T Burgering
AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1.
Nature 2000;404(6779):782-7.
1999: G J Boonen; Brigitte A van Oirschot; A van Diepen; Wendelina J M Mackus; L F Verdonck; Gert Rijksen; René H Medema
Cyclin D3 regulates proliferation and apoptosis of leukemic T cell lines.
The Journal of biological chemistry 1999;274(49):34676-82.
1999: Veronique A J Smits; Marieke A G Essers; D S Loomans; Rob Klompmaker; Gert Rijksen; René H Medema
Inhibition of cell proliferation by lithium is associated with interference in cdc2 activation.
FEBS letters 1999;457(1):23-7.
1999: G J Boonen; AM van Dijk; Leo F Verdonck; RA van Lier; Gert Rijksen; René H Medema
CD28 induces cell cycle progression by IL-2-independent down-regulation of p27kip1 expression in human peripheral T lymphocytes.
European journal of immunology 1999;29(3):789-98.
1998: Monique GCT van Oijen; René H Medema; P J Slootweg; Gert Rijksen
Positivity of the proliferation marker Ki-67 in noncycling cells.
American journal of clinical pathology 1998;110(1):24-31.
1998: René H Medema; Rob Klompmaker; Veronique A J Smits; Gert Rijksen
p21waf1 can block cells at two points in the cell cycle, but does not interfere with processive DNA-replication or stress-activated kinases.
Oncogene 1998;16(4):431-41.