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Juan Medina

Research Profile

Chemicals & Drugs

Disorders

Biliary Liver Cirrhosis

Anatomy

Living Beings

Mouse
Rats

Concepts & Ideas

Molecular Sequence Data

Physiology

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Immunohistochemistry

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Iker Uriarte; Umberto Vespasiani Gentilucci; Eva Vicente; Carmen Berasain; Simone Carotti; Haisul C Y Chang; Axel R Concepcion; Maite G Fernandez-Barrena; M Ujue Latasa; José Juan G Marin; Juan F Medina; Maria J Monte; Sergio Morini; Jesus Prieto; Matías A Avila
Identification of fibroblast growth factor 15 as a novel mediator of liver regeneration and its application in the prevention of post-resection liver failure in mice.
Jesús M Banales; Luis Bujanda; Juan F Medina; Jesús Prieto; Elena Sáez; Sarai Sarvide; Patrick Splinter; Pamela S Tietz Bogert; Miriam Uriz; Aura D Urribarri; Nicholas F LaRusso
Up-regulation of microRNA 506 leads to decreased Cl-/HCO3- anion exchanger 2 expression in biliary epithelium of patients with primary biliary cirrhosis.
Axel R Concepcion; Juan F Medina
Approaches to the pathogenesis of primary biliary cirrhosis through animal models.

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All Publications

2013: Iker Uriarte; Umberto Vespasiani Gentilucci; Eva Vicente; Carmen Berasain; Simone Carotti; Haisul C Y Chang; Axel R Concepcion; Maite G Fernandez-Barrena; M Ujue Latasa; José Juan G Marin; Juan F Medina; Maria J Monte; Sergio Morini; Jesus Prieto; Matías A Avila
Identification of fibroblast growth factor 15 as a novel mediator of liver regeneration and its application in the prevention of post-resection liver failure in mice.
Gut 2013;62(6):899-910.
2012: Jesús M Banales; Luis Bujanda; Juan F Medina; Jesús Prieto; Elena Sáez; Sarai Sarvide; Patrick Splinter; Pamela S Tietz Bogert; Miriam Uriz; Aura D Urribarri; Nicholas F LaRusso
Up-regulation of microRNA 506 leads to decreased Cl-/HCO3- anion exchanger 2 expression in biliary epithelium of patients with primary biliary cirrhosis.
Hepatology (Baltimore, Md.) 2012;56(2):687-97.
2012: Axel R Concepcion; Juan F Medina
Approaches to the pathogenesis of primary biliary cirrhosis through animal models.
Clinics and research in hepatology and gastroenterology 2012;36(1):21-8.
2011: Juan F Medina
Role of the anion exchanger 2 in the pathogenesis and treatment of primary biliary cirrhosis.
Digestive diseases (Basel, Switzerland) 2011;29(1):103-12.
2010: Carlos M Rodríguez-Ortigosa; Jesús M Banales; Israel Olivas; Iker Uriarte; José J G Marín; Fernando J Corrales; Juan F Medina; Jesús Prieto
Biliary secretion of S-nitrosoglutathione is involved in the hypercholeresis induced by ursodeoxycholic acid in the normal rat.
Hepatology (Baltimore, Md.) 2010;52(2):667-77.
2010: Iker Uriarte; Jesús M Banales; Elena Sáez; Fabián Arenas; Ronald P J Oude Elferink; Jesús Prieto; Juan F Medina
Bicarbonate secretion of mouse cholangiocytes involves Na(+)-HCO(3)(-) cotransport in addition to Na(+)-independent Cl(-)/HCO(3)(-) exchange.
Hepatology (Baltimore, Md.) 2010;51(3):891-902.
2008: January T Salas; Jesús M Banales; Sarai Sarvide; Sergio Recalde; Alex Ferrer; Iker Uriarte; Ronald P J Oude Elferink; Jesús Prieto; Juan F Medina
Ae2a,b-deficient mice develop antimitochondrial antibodies and other features resembling primary biliary cirrhosis.
Gastroenterology 2008;134(5):1482-93.
2008: Donacian M Lyaruu; Antonius L J J Bronckers; L Mulder; P Mardones; Juan F Medina; S Kellokumpu; R P J Oude Elferink; Vincent Everts
The anion exchanger Ae2 is required for enamel maturation in mouse teeth.
Matrix biology : journal of the International Society for Matrix Biology 2008;27(2):119-27.
2008: Fabián Arenas; Isabel Hervias; Miriam Uriz; Ruth Joplin; Jesús Prieto; Juan F Medina
Combination of ursodeoxycholic acid and glucocorticoids upregulates the AE2 alternate promoter in human liver cells.
The Journal of clinical investigation 2008;118(2):695-709.
2006: Sergio Recalde; Francisco Muruzábal; Norbert Looije; Cindy Kunne; María A Burrell; Elena Sáez; Eduardo Martínez-Ansó; January T Salas; Pablo Mardones; Jesús Prieto; Juan F Medina; Ronald P J Oude Elferink
Inefficient chronic activation of parietal cells in Ae2a,b(-/-) mice.
The American journal of pathology 2006;169(1):165-76.
2006: Jesús M Banales; Jesus Prieto; Juan F Medina
Cholangiocyte anion exchange and biliary bicarbonate excretion.
World journal of gastroenterology : WJG 2006;12(22):3496-511.
2006: Jesús M Banales; Fabián Arenas; Carlos M Rodríguez-Ortigosa; Elena Sáez; Iker Uriarte; R Brian Doctor; Jesús Prieto; Juan F Medina
Bicarbonate-rich choleresis induced by secretin in normal rat is taurocholate-dependent and involves AE2 anion exchanger.
Hepatology (Baltimore, Md.) 2006;43(2):266-75.
2004: Victoria Aranda; Iñigo Martínez; Saida Melero; Jon Lecanda; Jesús M Banales; Jesús Prieto; Juan F Medina
Shared apical sorting of anion exchanger isoforms AE2a, AE2b1, and AE2b2 in primary hepatocytes.
Biochemical and biophysical research communications 2004;319(3):1040-6.
2003: Juan F Medina; Sergio Recalde; Jesús Prieto; Jon Lecanda; Elena Saez; Colin D Funk; Paola Vecino; Marian A van Roon; Roelof Ottenhoff; Piter J Bosma; Conny T Bakker; Ronald P J Oude Elferink
Anion exchanger 2 is essential for spermiogenesis in mice.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(26):15847-52.
2003: Raquel Malumbres; Jon Lecanda; Saida Melero; Pawel Ciesielczyk; Jesús Prieto; Juan F Medina
HNF1alpha upregulates the human AE2 anion exchanger gene (SLC4A2) from an alternate promoter.
Biochemical and biophysical research communications 2003;311(1):233-40.
2002: Saida Melero; Carlo Spirlì; Ákos Zsembery; Juan F Medina; Ruth E Joplin; Elena Duner; Massimo Zuin; James M Neuberger; Jesús Prieto; Mario Strazzabosco
Defective regulation of cholangiocyte Cl-/HCO3(-) and Na+/H+ exchanger activities in primary biliary cirrhosis.
Hepatology (Baltimore, Md.) 2002;35(6):1513-21.
2001: Jon Lecanda; R Urtasun; Sergio Recalde; Jesús Prieto; Juan F Medina
A novel polymorphism IVS2+843C>T in the alternate promoter b1 of the human AE2 anion exchanger gene.
Human mutation 2001;17(1):82.
2000: Jon Lecanda; R Urtasun; Juan F Medina
Molecular cloning and genomic organization of the mouse AE2 anion exchanger gene.
Biochemical and biophysical research communications 2000;276(1):117-24.
2000: Juan F Medina
[Pathophysiology of biliary epithelium in primary biliary cirrhosis].
Gastroenterología y hepatología 2000;23 Suppl 1():4-9.
2000: J E Castillo; Eduardo Martínez-Ansó; Raquel Malumbres; Enrique de Alava; C García; Juan F Medina; Jesús Prieto
In situ localization of anion exchanger-2 in the human kidney.
Cell and tissue research 2000;299(2):281-7.
2000: Juan F Medina; Jon Lecanda; A Acín; P Ciesielczyk; Jesús Prieto
Tissue-specific N-terminal isoforms from overlapping alternate promoters of the human AE2 anion exchanger gene.
Biochemical and biophysical research communications 2000;267(1):228-35.
1999: Jesús Prieto; N García; Josep M Martí-Climent; Iván Peñuelas; José A Richter; Juan F Medina
Assessment of biliary bicarbonate secretion in humans by positron emission tomography.
Gastroenterology 1999;117(1):167-72.
1998: C García; L M Montuenga; Juan F Medina; Jesús Prieto
In situ detection of AE2 anion-exchanger mRNA in the human liver.
Cell and tissue research 1998;291(3):481-8.
1997: Jean-Yves Scoazec; Annie-France Bringuier; Juan F Medina; Eduardo Martínez-Ansó; D Veissiere; Gérard Feldmann; C Housset
The plasma membrane polarity of human biliary epithelial cells: in situ immunohistochemical analysis and functional implications.
Journal of hepatology 1997;26(3):543-53.
1997: Juan F Medina; A Acín; Jesús Prieto
Molecular cloning and characterization of the human AE2 anion exchanger (SLC4A2) gene.
Genomics 1997;39(1):74-85.
1997: Juan F Medina; J J Vazquez; Jesús Prieto
Decreased anion exchanger 2 immunoreactivity in the liver of patients with primary biliary cirrhosis.
Hepatology (Baltimore, Md.) 1997;25(1):12-7.
1995: J J Vázquez; M Vázquez; Miguel Angel Idoate or Idoate Gastearena; Luis M Montuenga; Eduardo Martínez-Ansó; J E Castillo; N García; Juan F Medina; Jesús Prieto
Anion exchanger immunoreactivity in human salivary glands in health and Sjögren's syndrome.
The American journal of pathology 1995;146(6):1422-32.
1995: C M Rodríguez-Ortigosa; I Vesperinas; Cheng Qian; Jorge Quiroga; Juan F Medina; Jesús Prieto
Taurocholate-stimulated leukotriene C4 biosynthesis and leukotriene C4-stimulated choleresis in isolated rat liver.
Gastroenterology 1995;108(6):1793-801.
1994: Eduardo Martínez-Ansó; J E Castillo; Javier Díez; Juan F Medina; Jesús Prieto
Immunohistochemical detection of chloride/bicarbonate anion exchangers in human liver.
Hepatology (Baltimore, Md.) 1994;19(6):1400-6.
1993: Jesús Prieto; Cheng Qian; N García; Javier Díez; Juan F Medina
Abnormal expression of anion exchanger genes in primary biliary cirrhosis.
Gastroenterology 1993;105(2):572-8.
1992: Cheng Qian; Javier Díez; Esther Larrea; A Garciandía; A Arrazola; Maria Pilar Civeira; Juan F Medina; Jesús Prieto
The stilbene disulfonic acid DIDS stimulates the production of TNF-alpha in human lymphocytes.
Biochemical and biophysical research communications 1992;189(3):1268-74.
1986: Juan F Medina; Jesús Prieto; Francisco Guarner; Jorge Quiroga; A Milazzo
Effect of spironolactone on renal prostaglandin excretion in patients with liver cirrhosis and ascites.
Journal of hepatology 1986;3(2):206-11.
1984: A Milazzo; J Yanguela; Juan F Medina; J M Campo; P Labarga; F J Salcedo
[Alcoholic hepatitis. Apropos of 27 cases].
Revista clínica española 1984;175(5-6):215-8.