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Edward Medof

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Chemicals & Drugs

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Paroxysmal Hemoglobinuria

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Olga N Karpus; M Edward Medof; Kris A Reedquist; Jaap D van Buul; René A W van Lier; Ed vanBavel; Corianne C Vandenakker; Henrike Veninga; Dennis Flierman; Robert M Hoek; Jörg Hamann
Shear stress-dependent downregulation of the adhesion-G protein-coupled receptor CD97 on circulating leukocytes upon contact with its ligand CD55.
Michael G Strainic; Ethan M Shevach; Fengqi An; Feng Lin; M Edward Medof
Absence of signaling into CD4⁺ cells via C3aR and C5aR enables autoinductive TGF-β1 signaling and induction of Foxp3⁺ regulatory T cells.
Wing-Hong Kwan; M Edward Medof; Miriam Merad; Katya Ostrow; Estela Paz-Artal; Hugo Raedler; Melanie Greter; Daigo Hashimoto; Peter S Heeger
Antigen-presenting cell-derived complement modulates graft-versus-host disease.

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2013: Olga N Karpus; M Edward Medof; Kris A Reedquist; Jaap D van Buul; René A W van Lier; Ed vanBavel; Corianne C Vandenakker; Henrike Veninga; Dennis Flierman; Robert M Hoek; Jörg Hamann
Shear stress-dependent downregulation of the adhesion-G protein-coupled receptor CD97 on circulating leukocytes upon contact with its ligand CD55.
Journal of immunology (Baltimore, Md. : 1950) 2013;190(7):3740-8.
2013: Michael G Strainic; Ethan M Shevach; Fengqi An; Feng Lin; M Edward Medof
Absence of signaling into CD4⁺ cells via C3aR and C5aR enables autoinductive TGF-β1 signaling and induction of Foxp3⁺ regulatory T cells.
Nature immunology 2013;14(2):162-71.
2012: Wing-Hong Kwan; M Edward Medof; Miriam Merad; Katya Ostrow; Estela Paz-Artal; Hugo Raedler; Melanie Greter; Daigo Hashimoto; Peter S Heeger
Antigen-presenting cell-derived complement modulates graft-versus-host disease.
The Journal of clinical investigation 2012;122(6):2234-8.
2011: Henrike Veninga; Feng-Qi An; Alex M de Bruin; Alex F de Vos; Robert M Hoek; M Edward Medof; Tom van der Poll; René A W van Lier; Jörg Hamann
A novel role for CD55 in granulocyte homeostasis and anti-bacterial host defense.
PloS one 2011;6(10):e24431.
2010: Pavel Plevka; Susan Hafenstein; Katherine G Harris; Javier O Cifuente; Ying Zhang; valorie bowman; Paul R Chipman; Carol M Bator; Feng Lin; M Edward Medof; Michael G Rossmann
Interaction of decay-accelerating factor with echovirus 7.
Journal of virology 2010;84(24):12665-74.
2010: Marvin Lin; Na Yin; Barbara Murphy; M Edward Medof; Stephan Segerer; Peter S Heeger; Bernd Schroppel
Immune cell-derived c3 is required for autoimmune diabetes induced by multiple low doses of streptozotocin.
Diabetes 2010;59(9):2247-52.
2010: Masashi Sakuma; Toshifumi Morooka; Yunmei Wang; Can Shi; Kevin Croce; Huiyun Gao; Michael Strainic; M Edward Medof; Daniel I Simon
The intrinsic complement regulator decay-accelerating factor modulates the biological response to vascular injury.
Arteriosclerosis, thrombosis, and vascular biology 2010;30(6):1196-202.
2010: Robert M Hoek; Daphne de Launay; Else N Kop; A Seda Yilmaz-Elis; Feng Lin; Kris A Reedquist; J Sjef Verbeek; M Edward Medof; Paul P Tak; Jörg Hamann
Deletion of either CD55 or CD97 ameliorates arthritis in mouse models.
Arthritis and rheumatism 2010;62(4):1036-42.
2010: A Esposito; B Suedekum; Jinbo Liu; F An; Jonathan H Lass; Michael G Strainic; Feng Lin; Peter S Heeger; M Edward Medof
Decay accelerating factor is essential for successful corneal engraftment.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2010;10(3):527-34.
2009: Sanjoy Roychowdhury; Megan R McMullen; Michele T Pritchard; Amy G Hise; Nico van Rooijen; M Edward Medof; Abram B Stavitsky; Laura E Nagy
An early complement-dependent and TLR-4-independent phase in the pathogenesis of ethanol-induced liver injury in mice.
Hepatology (Baltimore, Md.) 2009;49(4):1326-34.
2009: Peter N Lalli; Wuding Zhou; Steven Sacks; M Edward Medof; Peter S Heeger
Locally produced and activated complement as a mediator of alloreactive T cells.
Frontiers in bioscience (Scholar edition) 2009;1():117-24.
2008: Vasile Pavlov; Hugo Raedler; Shuguang Yuan; Staci Leisman; Wing-Hong Kwan; Peter N Lalli; M Edward Medof; Peter S Heeger
Donor deficiency of decay-accelerating factor accelerates murine T cell-mediated cardiac allograft rejection.
Journal of immunology (Baltimore, Md. : 1950) 2008;181(7):4580-9.
2008: Peter N Lalli; Michael G Strainic; Min Yang; Feng Lin; M Edward Medof; Peter S Heeger
Locally produced C5a binds to T cell-expressed C5aR to enhance effector T-cell expansion by limiting antigen-induced apoptosis.
Blood 2008;112(5):1759-66.
2008: Jinbo Liu; Feng Lin; Michael G Strainic; Fengqi An; Robert H Miller; Cengiz Z Altuntas; Peter S Heeger; Vincent K Tuohy; M Edward Medof
IFN-gamma and IL-17 production in experimental autoimmune encephalomyelitis depends on local APC-T cell complement production.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(9):5882-9.
2008: Michael G Strainic; Jinbo Liu; Danping Huang; Fengqi An; Peter N Lalli; Nasima Muqim; Virginia S Shapiro; George R Dubyak; Peter S Heeger; M Edward Medof
Locally produced complement fragments C5a and C3a provide both costimulatory and survival signals to naive CD4+ T cells.
Immunity 2008;28(3):425-35.
2008: Michele T Pritchard; Megan R McMullen; M Edward Medof; Abram Stavitsky; Laura E Nagy
Role of complement in ethanol-induced liver injury.
Advances in experimental medicine and biology 2008;632():175-86.
2007: Yuefang Zhou; Bendi Gong; Feng Lin; Russell P Rother; M Edward Medof; Henry J Kaminski
Anti-C5 antibody treatment ameliorates weakness in experimentally acquired myasthenia gravis.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(12):8562-7.
2007: Susan Hafenstein; valorie bowman; Paul R Chipman; Carol M Bator Kelly; Feng Lin; M Edward Medof; Michael G Rossmann
Interaction of decay-accelerating factor with coxsackievirus B3.
Journal of virology 2007;81(23):12927-35.
2007: Peter N Lalli; Michael G Strainic; Feng Lin; M Edward Medof; Peter S Heeger
Decay accelerating factor can control T cell differentiation into IFN-gamma-producing effector cells via regulating local C5a-induced IL-12 production.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(9):5793-802.
2007: Wuding Zhou; M Edward Medof; Peter S Heeger; Steven Sacks
Graft-derived complement as a mediator of transplant injury.
Current opinion in immunology 2007;19(5):569-76.
2007: Lisa A Kuttner-Kondo; Dennis E Hourcade; Vernon E Anderson; Nasima Muqim; Lynne Mitchell; Dinesh C Soares; Paul N Barlow; M Edward Medof
Structure-based mapping of DAF active site residues that accelerate the decay of C3 convertases.
The Journal of biological chemistry 2007;282(25):18552-62.
2007: Michele T Pritchard; Megan R McMullen; Abram B Stavitsky; Jessica I Cohen; Feng Lin; M Edward Medof; Laura E Nagy
Differential contributions of C3, C5, and decay-accelerating factor to ethanol-induced fatty liver in mice.
Gastroenterology 2007;132(3):1117-26.
2006: Henry J Kaminski; Linda L Kusner; Chelliah R Richmonds; M Edward Medof; Feng Lin
Deficiency of decay accelerating factor and CD59 leads to crisis in experimental myasthenia.
Experimental neurology 2006;202(2):287-93.
2006: Daniel P O'Brien; Dawn A Israel; Uma Krishna; Judith Romero-Gallo; John G Nedrud; M Edward Medof; Feng Lin; Raymond W Redline; Douglas M Lublin; Bogdan Nowicki; Aime T Franco; Seth Ogden; Amanda D Williams; D Brent Polk; Richard M Peek
The role of decay-accelerating factor as a receptor for Helicobacter pylori and a mediator of gastric inflammation.
The Journal of biological chemistry 2006;281(19):13317-23.
2005: Peter S Heeger; Peter N Lalli; Feng Lin; Anna Valujskikh; Jinbo Liu; Nasima Muqim; Yuanyuan Xu; M Edward Medof
Decay-accelerating factor modulates induction of T cell immunity.
The Journal of experimental medicine 2005;201(10):1523-30.
2004: Henry J Kaminski; Zhuyi Li; Chelliah R Richmonds; Feng Lin; M Edward Medof
Complement regulators in extraocular muscle and experimental autoimmune myasthenia gravis.
Experimental neurology 2004;189(2):333-42.
2004: Kirstine L Anderson; Jason Billington; David Pettigrew; Ernesto Cota; Pete Simpson; Pietro Roversi; Ho An Chen; Petri Urvil; Laurence du Merle; Paul N Barlow; M Edward Medof; Richard A G Smith; Bogdan Nowicki; Chantal Le Bouguénec; Susan M Lea; Stephen Matthews
An atomic resolution model for assembly, architecture, and function of the Dr adhesins.
Molecular cell 2004;15(4):647-57.
2004: Feng Lin; David Spencer; Denise A Hatala; Alan D Levine; M Edward Medof
Decay-accelerating factor deficiency increases susceptibility to dextran sulfate sodium-induced colitis: role for complement in inflammatory bowel disease.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(6):3836-41.
2004: Feng Lin; David J Salant; Howard J Meyerson; Steven N Emancipator; B Paul Morgan; M Edward Medof
Respective roles of decay-accelerating factor and CD59 in circumventing glomerular injury in acute nephrotoxic serum nephritis.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(4):2636-42.
2003: Lisa A Kuttner-Kondo; Megan P Dybvig; Lynne M Mitchell; Nasima Muqim; John P Atkinson; M Edward Medof; Dennis E Hourcade
A corresponding tyrosine residue in the C2/factor B type A domain is a hot spot in the decay acceleration of the complement C3 convertases.
The Journal of biological chemistry 2003;278(52):52386-91.
2003: Stanislava Uhrinova; Feng Lin; Graeme Ball; Krystyna Bromek; Dusan Uhrin; M Edward Medof; Paul N Barlow
Solution structure of a functionally active fragment of decay-accelerating factor.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(8):4718-23.
2003: Ruliang Li; Tong Liu; Fukuoka Yoshihiro; Magdalena Tary-Lehmann; Mark E Obrenovich; Haydar Kuekrek; Shin-Chung Kang; Tao Pan; Boon-Seng Wong; M Edward Medof; Man-Sun Sy
On the same cell type GPI-anchored normal cellular prion and DAF protein exhibit different biological properties.
Biochemical and biophysical research communications 2003;303(2):446-51.
2003: Rui Chen; Vernon Anderson; Yukio Hiroi; M Edward Medof
Proprotein interaction with the GPI transamidase.
Journal of cellular biochemistry 2003;88(5):1025-37.
2003: Y Fukuoka; Michael G Strainic; M Edward Medof
Differential cytokine expression of human retinal pigment epithelial cells in response to stimulation by C5a.
Clinical and experimental immunology 2003;131(2):248-53.
2002: Feng Lin; Henry J Kaminski; Bianca M Conti-Fine; Wei Wang; Chelliah R Richmonds; M Edward Medof
Markedly enhanced susceptibility to experimental autoimmune myasthenia gravis in the absence of decay-accelerating factor protection.
The Journal of clinical investigation 2002;110(9):1269-74.
2002: Yongning He; Feng Lin; Paul R Chipman; Carol M Bator; Timothy S Baker; Menachem Shoham; Richard J Kuhn; M Edward Medof; Michael G Rossmann
Structure of decay-accelerating factor bound to echovirus 7: a virus-receptor complex.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(16):10325-9.
2002: Stanislava Uhrínová; Feng Lin; Du Usan Uhrín; M Edward Medof; Paul N Barlow
Letter to the Editor: Resonance assignments of the central complement control protein module pair of human decay accelerating factor.
Journal of biomolecular NMR 2002;23(2):167-8.
2002: Stanislava Uhrínová; Feng Lin; Dusan Uhrín; M Edward Medof; Paul N Barlow
Resonance assignments of the central complement control protein module pair of human decay accelerating factor.
Journal of biomolecular NMR 2002;23(2):167-8.
2002: Feng Lin; Steven N Emancipator; David J Salant; M Edward Medof
Decay-accelerating factor confers protection against complement-mediated podocyte injury in acute nephrotoxic nephritis.
Laboratory investigation; a journal of technical methods and pathology 2002;82(5):563-9.
2002: A Dharshan De Silva; Jang-June Park; Naoto Matsuki; Aleksandar Stanic; Randy R Brutkiewicz; M Edward Medof; Sebastian JOYCE
Lipid protein interactions: the assembly of CD1d1 with cellular phospholipids occurs in the endoplasmic reticulum.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(2):723-33.
2002: Dennis E Hourcade; Lynne Mitchell; Lisa A Kuttner-Kondo; John P Atkinson; M Edward Medof
Decay-accelerating factor (DAF), complement receptor 1 (CR1), and factor H dissociate the complement AP C3 convertase (C3bBb) via sites on the type A domain of Bb.
The Journal of biological chemistry 2002;277(2):1107-12.
2001: David S Bardenstein; Christopher J Cheyer; C Lee; Enzo Cocuzzi; M Mizuno; N Okada; M Edward Medof
Blockage of complement regulators in the conjunctiva and within the eye leads to massive inflammation and iritis.
Immunology 2001;104(4):423-30.
2001: Daniel Sevlever; Karl J Mann; M Edward Medof
Differential effect of 1,10-phenanthroline on mammalian, yeast, and parasite glycosylphosphatidylinositol anchor synthesis.
Biochemical and biophysical research communications 2001;288(5):1112-8.
2001: Feng Lin; Y Fukuoka; A Spicer; R Ohta; N Okada; C L Harris; Steven N Emancipator; M Edward Medof
Tissue distribution of products of the mouse decay-accelerating factor (DAF) genes. Exploitation of a Daf1 knock-out mouse and site-specific monoclonal antibodies.
Immunology 2001;104(2):215-25.
2001: Feng Lin; R M Immormino; Menachem Shoham; M Edward Medof
Bulk production and functional analyses of mouse CD55's native and deglycosylated active domains.
Archives of biochemistry and biophysics 2001;393(1):67-72.
2001: Lisa A Kuttner-Kondo; Lynne Mitchell; Dennis E Hourcade; M Edward Medof
Characterization of the active sites in decay-accelerating factor.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(4):2164-71.
2001: Enzo Cocuzzi; David S Bardenstein; Abram B Stavitsky; N Sundarraj; M Edward Medof
Upregulation of DAF (CD55) on orbital fibroblasts by cytokines. Differential effects of TNF-beta and TNF-alpha.
Current eye research 2001;23(2):86-92.
2001: Enzo Cocuzzi; Loretta B Szczotka; William G Brodbeck; David S Bardenstein; T Wei; M Edward Medof
Tears contain the complement regulator CD59 as well as decay-accelerating factor (DAF).
Clinical and experimental immunology 2001;123(2):188-95.
2001: Rui Chen; James R Eshleman; Robert A Brodsky; M Edward Medof
Glycophosphatidylinositol-anchored protein deficiency as a marker of mutator phenotypes in cancer.
Cancer research 2001;61(2):654-8.
2001: Rui Chen; jansen knez; William C Merrick; M Edward Medof
Comparative efficiencies of C-terminal signals of native glycophosphatidylinositol (GPI)-anchored proproteins in conferring GPI-anchoring.
Journal of cellular biochemistry 2001;84(1):68-83.
2001: DR Premkumar; Y Fukuoka; Daniel Sevlever; Elaine B Brunschwig; Terrone L Rosenberry; Mark L Tykocinski; M Edward Medof
Properties of exogenously added GPI-anchored proteins following their incorporation into cells.
Journal of cellular biochemistry 2001;82(2):234-45.
2000: Lisa A Kuttner-Kondo; VB Subramanian; John P Atkinson; J Yu; M Edward Medof
Conservation in decay accelerating factor (DAF) structure among primates.
Developmental and comparative immunology 2000;24(8):815-27.
2000: Loretta B Szczotka; Enzo Cocuzzi; M Edward Medof
Decay-accelerating factor in tears of contact lens wearers and patients with contact lens-associated complications.
Optometry and vision science : official publication of the American Academy of Optometry 2000;77(11):586-91.
2000: William G Brodbeck; Carolyn Mold; John P Atkinson; M Edward Medof
Cooperation between decay-accelerating factor and membrane cofactor protein in protecting cells from autologous complement attack.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(7):3999-4006.
2000: William G Brodbeck; Lisa A Kuttner-Kondo; Carolyn Mold; M Edward Medof
Structure/function studies of human decay-accelerating factor.
Immunology 2000;101(1):104-11.
2000: Rui Chen; S Nagarajan; G M Prince; U Maheshwari; L W Terstappen; D R Kaplan; Stanton L Gerson; Jeffrey M Albert; Daniel E Dunn; Hillard M Lazarus; M Edward Medof
Impaired growth and elevated fas receptor expression in PIGA(+) stem cells in primary paroxysmal nocturnal hemoglobinuria.
The Journal of clinical investigation 2000;106(5):689-96.
2000: Yukio Hiroi; R Chen; H Sawa; Toru Hosoda; Sumiyo Kudoh; Y Kobayashi; Hiroyuki Aburatani; K Nagashima; Ryozo Nagai; Yoshio Yazaki; M Edward Medof; Issei Komuro
Cloning of murine glycosyl phosphatidylinositol anchor attachment protein, GPAA1.
American journal of physiology. Cell physiology 2000;279(1):C205-12.
2000: John D Fayen; Mark L Tykocinski; M Edward Medof
Glycerolphosphoinositide anchors for membrane-tethering proteins.
Methods in enzymology 2000;327():351-68.
1999: Daniel Sevlever; S Pickett; Karl J Mann; Kumar Sambamurti; M Edward Medof; Terrone L Rosenberry
Glycosylphosphatidylinositol-anchor intermediates associate with triton-insoluble membranes in subcellular compartments that include the endoplasmic reticulum.
The Biochemical journal 1999;343 Pt 3():627-35.
1999: Elaine B Brunschwig; John D Fayen; M Edward Medof; Mark L Tykocinski
Protein transfer of glycosyl-phosphatidylinositol (GPI)-modified murine B7-1 and B7-2 costimulators.
Journal of immunotherapy (Hagerstown, Md. : 1997) 1999;22(5):390-400.
1999: Dennis E Hourcade; Lynne M Mitchell; M Edward Medof
Decay acceleration of the complement alternative pathway C3 convertase.
Immunopharmacology 1999;42(1-3):167-73.
1999: J W Harris; R Koscick; Hillard M Lazarus; James R Eshleman; M Edward Medof
Leukemia arising out of paroxysmal nocturnal hemoglobinuria.
Leukemia & lymphoma 1999;32(5-6):401-26.
1999: David S Bardenstein; Christopher J Cheyer; N Okada; B P Morgan; M Edward Medof
Cell surface regulators of complement, 5I2 antigen, and CD59, in the rat eye and adnexal tissues.
Investigative ophthalmology & visual science 1999;40(2):519-24.
1998: Yukio Hiroi; Issei Komuro; Ikumi Matsushita; Hiroyuki Aburatani; Toru Hosoda; Yutaka Nakahori; M Edward Medof; Yoshio Yazaki
Assignment of the human GPAA1 gene, which encodes a product required for the attachment of glycosylphosphatidylinositols to proteins, at 8q24.
Genomics 1998;54(2):354-5.
1998: Rui Chen; E I Walter; G Parker; J P Lapurga; J L Millan; Y Ikehara; S Udenfriend; M Edward Medof
Mammalian glycophosphatidylinositol anchor transfer to proteins and posttransfer deacylation.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(16):9512-7.
1998: D Kraus; M Edward Medof; Carolyn Mold
Complementary recognition of alternative pathway activators by decay-accelerating factor and factor H.
Infection and immunity 1998;66(2):399-405.
1998: Yukio Hiroi; Issei Komuro; R Chen; Toru Hosoda; T Mizuno; Sumiyo Kudoh; S P Georgescu; M Edward Medof; Yoshio Yazaki
Molecular cloning of human homolog of yeast GAA1 which is required for attachment of glycosylphosphatidylinositols to proteins.
FEBS letters 1998;421(3):252-8.
1997: Michael Hobert; Song Jae Kil; M Edward Medof; Cathleen Carlin
The cytoplasmic juxtamembrane domain of the epidermal growth factor receptor contains a novel autonomous basolateral sorting determinant.
The Journal of biological chemistry 1997;272(52):32901-9.
1997: David S Bardenstein; S Sauer; Loretta B Szczotka; M Edward Medof
Detection of complement regulatory proteins on soft contact lenses.
Current eye research 1997;16(12):1270-3.
1997: J Yu; S Nagarajan; jansen knez; S Udenfriend; Rui Chen; M Edward Medof
The affected gene underlying the class K glycosylphosphatidylinositol (GPI) surface protein defect codes for the GPI transamidase.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(23):12580-5.
1997: Robert A Brodsky; Milada S Vala; Jamie P Barber; M Edward Medof; Richard J Jones
Resistance to apoptosis caused by PIG-A gene mutations in paroxysmal nocturnal hemoglobinuria.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(16):8756-60.
1997: MP Devetten; Johnson Ming-Yu Liu; V Ling; Frank F Weichold; J Yu; M Edward Medof; Neal S Young; Daniel E Dunn
Paroxysmal nocturnal hemoglobinuria: new insights from murine Pig-a-deficient hematopoiesis.
Proceedings of the Association of American Physicians 1997;109(2):99-110.
1997: Daniel Sevlever; D Schiemann; J Guidubaldi; M Edward Medof; Terrone L Rosenberry
Accumulation of glucosaminyl(acyl)phosphatidylinositol in an S3 HeLa subline expressing normal dolicholphosphomannose synthase activity.
The Biochemical journal 1997;321 ( Pt 3)():837-44.
1997: William G Brodbeck; M Edward Medof
Use of recombinant DAF proteins to localize the epitopes recognized by monoclonal anti-CD55.
Transfusion clinique et biologique : journal de la Société française de transfusion sanguine 1997;4(1):125-6.
1996: L Kuttner-Kondo; M Edward Medof; W Brodbeck; Menachem Shoham
Molecular modeling and mechanism of action of human decay-accelerating factor.
Protein engineering 1996;9(12):1143-9.
1996: S Ramalingam; S E Maxwell; M Edward Medof; Rui Chen; L D Gerber; S Udenfriend
COOH-terminal processing of nascent polypeptides by the glycosylphosphatidylinositol transamidase in the presence of hydrazine is governed by the same parameters as glycosylphosphatidylinositol addition.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(15):7528-33.
1996: W G Brodbeck; Dacai Liu; J Sperry; C Mold; M Edward Medof
Localization of classical and alternative pathway regulatory activity within the decay-accelerating factor.
Journal of immunology (Baltimore, Md. : 1950) 1996;156(7):2528-33.
1996: M Edward Medof; S Nagarajan; Mark L Tykocinski
Cell-surface engineering with GPI-anchored proteins.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1996;10(5):574-86.
1996: Rui Chen; S Udenfriend; G M Prince; S E Maxwell; S Ramalingam; L D Gerber; J Knez; M Edward Medof
A defect in glycosylphosphatidylinositol (GPI) transamidase activity in mutant K cells is responsible for their inability to display GPI surface proteins.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(6):2280-4.
1995: S Nagarajan; Robert A Brodsky; N S Young; M Edward Medof
Genetic defects underlying paroxysmal nocturnal hemoglobinuria that arises out of aplastic anemia.
Blood 1995;86(12):4656-61.
1995: G M Prince; M Nguyen; H M Lazarus; Robert A Brodsky; L W Terstappen; M Edward Medof
Peripheral blood harvest of unaffected CD34+ CD38- hematopoietic precursors in paroxysmal nocturnal hemoglobinuria.
Blood 1995;86(9):3381-6.
1995: S Nagarajan; C J Brown; M Edward Medof
Identification of a PIG-A related processed gene on chromosome 12.
Human genetics 1995;95(6):691-7.
1995: J Yu; S Nagarajan; Johnson Ming-Yu Liu; N Young; M Edward Medof
Cloning and characterization of the mouse PIG-A gene.
Biochimica et biophysica acta 1995;1255(3):344-50.
1995: S Hirose; jansen knez; M Edward Medof
Mammalian glycosylphosphatidylinositol-anchored proteins and intracellular precursors.
Methods in enzymology 1995;250():582-614.
1995: H A Stafford; S Nagarajan; J B Weinberg; M Edward Medof
PIG-A, DAF and proto-oncogene expression in paroxysmal nocturnal haemoglobinuria-associated acute myelogenous leukaemia blasts.
British journal of haematology 1995;89(1):72-8.
1994: David S Bardenstein; Y Dietz; Jonathan H Lass; M Edward Medof
Localization of the complement membrane attack complex inhibitor (CD59) in human conjunctiva and lacrimal gland.
Current eye research 1994;13(12):851-5.
1994: D F Lazar; jansen knez; M Edward Medof; P Cuatrecasas; Alan Saltiel
Stimulation of glycogen synthesis by insulin in human erythroleukemia cells requires the synthesis of glycosyl-phosphatidylinositol.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(21):9665-9.
1994: R P Mohney; jansen knez; L Ravi; Daniel Sevlever; Terrone L Rosenberry; S Hirose; M Edward Medof
Glycoinositol phospholipid anchor-defective K562 mutants with biochemical lesions distinct from those in Thy-1- murine lymphoma mutants.
The Journal of biological chemistry 1994;269(9):6536-42.
1994: J Yu; S Nagarajan; E Ueda; jansen knez; Robert B Petersen; M Edward Medof
Characterization of alternatively spliced PIG-A transcripts in normal and paroxysmal nocturnal hemoglobinuria cells.
Brazilian journal of medical and biological research = Revista brasileira de pesquisas médicas e biológicas / Sociedade Brasileira de Biofísica ... [et al.] 1994;27(2):195-201.
1994: Terrone L Rosenberry; Daniel Sevlever; M Edward Medof
Metabolism of GPIs in mammalian cells.
Brazilian journal of medical and biological research = Revista brasileira de pesquisas médicas e biológicas / Sociedade Brasileira de Biofísica ... [et al.] 1994;27(2):151-9.
1993: Roslyn Yomtovian; G M Prince; M Edward Medof
The molecular basis for paroxysmal nocturnal hemoglobinuria.
Transfusion 1993;33(10):852-73.
1993: R H Wang; G Phillips; M Edward Medof; Carolyn Mold
Activation of the alternative complement pathway by exposure of phosphatidylethanolamine and phosphatidylserine on erythrocytes from sickle cell disease patients.
The Journal of clinical investigation 1993;92(3):1326-35.
1993: E Ueda; Daniel Sevlever; G M Prince; Terrone L Rosenberry; S Hirose; M Edward Medof
A candidate mammalian glycoinositol phospholipid precursor containing three phosphoethanolamines.
The Journal of biological chemistry 1993;268(14):9998-10002.
1993: K E Long; Roslyn Yomtovian; M Kida; jansen knez; M Edward Medof
Time-dependent loss of surface complement regulatory activity during storage of donor blood.
Transfusion 1993;33(4):294-300.
1993: J Schubert; R E Schmidt; M Edward Medof
Regulation of glycoinositol phospholipid anchor assembly in human lymphocytes. Absent mannolipid synthesis in affected T and natural killer cell lines from paroxysmal nocturnal hemoglobinuria patients.
The Journal of biological chemistry 1993;268(9):6281-7.
1992: C Armstrong; J Schubert; E Ueda; jansen knez; D Gelperin; S Hirose; R Silber; S Hollan; R E Schmidt; M Edward Medof
Affected paroxysmal nocturnal hemoglobinuria T lymphocytes harbor a common defect in assembly of N-acetyl-D-glucosamine inositol phospholipid corresponding to that in class A Thy-1- murine lymphoma mutants.
The Journal of biological chemistry 1992;267(35):25347-51.
1992: S Hirose; G M Prince; Daniel Sevlever; L Ravi; Terrone L Rosenberry; E Ueda; M Edward Medof
Characterization of putative glycoinositol phospholipid anchor precursors in mammalian cells. Localization of phosphoethanolamine.
The Journal of biological chemistry 1992;267(24):16968-74.
1992: S Hirose; L Ravi; G M Prince; M G Rosenfeld; R Silber; S W Andresen; S V Hazra; M Edward Medof
Synthesis of mannosylglucosaminylinositol phospholipids in normal but not paroxysmal nocturnal hemoglobinuria cells.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(13):6025-9.
1992: S Hirose; R P Mohney; S C Mutka; L Ravi; D R Singleton; George Perry; Alan M Tartakoff; M Edward Medof
Derivation and characterization of glycoinositol-phospholipid anchor-defective human K562 cell clones.
The Journal of biological chemistry 1992;267(8):5272-8.
1992: W D Ratnoff; jansen knez; G M Prince; H Okada; Peter Lachmann; M Edward Medof
Structural properties of the glycoplasmanylinositol anchor phospholipid of the complement membrane attack complex inhibitor CD59.
Clinical and experimental immunology 1992;87(3):415-21.
1992: E I Walter; W D Ratnoff; K E Long; J W Kazura; M Edward Medof
Effect of glycoinositolphospholipid anchor lipid groups on functional properties of decay-accelerating factor protein in cells.
The Journal of biological chemistry 1992;267(2):1245-52.
1991: U K Ewulonu; L Ravi; M Edward Medof
Characterization of the decay-accelerating factor gene promoter region.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(11):4675-9.
1991: S Hirose; L Ravi; S V Hazra; M Edward Medof
Assembly and deacetylation of N-acetylglucosaminyl-plasmanylinositol in normal and affected paroxysmal nocturnal hemoglobinuria cells.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(9):3762-6.
1990: Carolyn Mold; E I Walter; M Edward Medof
The influence of membrane components on regulation of alternative pathway activation by decay-accelerating factor.
Journal of immunology (Baltimore, Md. : 1950) 1990;145(11):3836-41.
1990: Jonathan H Lass; E I Walter; T E Burris; H E Grossniklaus; M I Roat; D L Skelnik; L Needham; M Singer; M Edward Medof
Expression of two molecular forms of the complement decay-accelerating factor in the eye and lacrimal gland.
Investigative ophthalmology & visual science 1990;31(6):1136-48.
1990: E I Walter; W L Roberts; Terrone L Rosenberry; W D Ratnoff; M Edward Medof
Structural basis for variations in the sensitivity of human decay accelerating factor to phosphatidylinositol-specific phospholipase C cleavage.
Journal of immunology (Baltimore, Md. : 1950) 1990;144(3):1030-6.
1990: D J Carothers; S V Hazra; S W Andreson; M Edward Medof
Synthesis of aberrant decay-accelerating factor proteins by affected paroxysmal nocturnal hemoglobinuria leukocytes.
The Journal of clinical investigation 1990;85(1):47-54.
1989: Michael M Lederman; SF Purvis; E I Walter; J T Carey; M Edward Medof
Heightened complement sensitivity of acquired immunodeficiency syndrome lymphocytes related to diminished expression of decay-accelerating factor.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(11):4205-9.
1988: Gary M Kammer; E I Walter; M Edward Medof
Association of cytoskeletal re-organization with capping of the complement decay-accelerating factor on T lymphocytes.
Journal of immunology (Baltimore, Md. : 1950) 1988;141(9):2924-8.
1988: Mark L Tykocinski; H K Shu; D J Ayers; E I Walter; R R Getty; R K Groger; C A Hauer; M Edward Medof
Glycolipid reanchoring of T-lymphocyte surface antigen CD8 using the 3' end sequence of decay-accelerating factor's mRNA.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(10):3555-9.
1988: Nai-Kong V Cheung; E I Walter; W H Smith-Mensah; W D Ratnoff; Mark L Tykocinski; M Edward Medof
Decay-accelerating factor protects human tumor cells from complement-mediated cytotoxicity in vitro.
The Journal of clinical investigation 1988;81(4):1122-8.
1988: H A Stafford; Mark L Tykocinski; D M Lublin; V M Holers; W F Rosse; J P Atkinson; M Edward Medof
Normal polymorphic variations and transcription of the decay accelerating factor gene in paroxysmal nocturnal hemoglobinuria cells.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(3):880-4.
1987: D M Lublin; R S Lemons; M M Le Beau; V M Holers; M L Tykocinski; M Edward Medof; J P Atkinson
The gene encoding decay-accelerating factor (DAF) is located in the complement-regulatory locus on the long arm of chromosome 1.
The Journal of experimental medicine 1987;165(6):1731-6.
1987: M Edward Medof; D M Lublin; V Michael Holers; D J Ayers; R R Getty; J F Leykam; J P Atkinson; Mark L Tykocinski
Cloning and characterization of cDNAs encoding the complete sequence of decay-accelerating factor of human complement.
Proceedings of the National Academy of Sciences of the United States of America 1987;84(7):2007-11.
1987: M Edward Medof; E I Walter; J L Rutgers; D M Knowles; V Nussenzweig
Identification of the complement decay-accelerating factor (DAF) on epithelium and glandular cells and in body fluids.
The Journal of experimental medicine 1987;165(3):848-64.
1986: M Edward Medof; E I Walter; W L Roberts; R Haas; Terrone L Rosenberry
Decay accelerating factor of complement is anchored to cells by a C-terminal glycolipid.
Biochemistry 1986;25(22):6740-7.