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Andrei Medvedev

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Yanbao Xiong; Greg A Snyder; Chang Song; Eric Sundberg; Andrei E Medvedev
R753Q polymorphism inhibits Toll-like receptor (TLR) 2 tyrosine phosphorylation, dimerization with TLR6, and recruitment of myeloid differentiation primary response protein 88.
Melissa W Hayes; Andrei E Medvedev; Jerritt Nunneley; Maria Salvato; Ricardo Carrion; Igor S Lukashevich
Pathogenic Old World arenaviruses inhibit TLR2/Mal-dependent proinflammatory cytokines in vitro.
Leandra Figueroa; Wenji Piao; Chang Song; Stefanie N Vogel; Yanbao Xiong; Andrei E Medvedev
The Asp299Gly polymorphism alters TLR4 signaling by interfering with recruitment of MyD88 and TRIF.

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All Publications

2012: Yanbao Xiong; Greg A Snyder; Chang Song; Eric Sundberg; Andrei E Medvedev
R753Q polymorphism inhibits Toll-like receptor (TLR) 2 tyrosine phosphorylation, dimerization with TLR6, and recruitment of myeloid differentiation primary response protein 88.
The Journal of biological chemistry 2012;287(45):38327-37.
2012: Melissa W Hayes; Andrei E Medvedev; Jerritt Nunneley; Maria Salvato; Ricardo Carrion; Igor S Lukashevich
Pathogenic Old World arenaviruses inhibit TLR2/Mal-dependent proinflammatory cytokines in vitro.
Journal of virology 2012;86(13):7216-26.
2012: Leandra Figueroa; Wenji Piao; Chang Song; Stefanie N Vogel; Yanbao Xiong; Andrei E Medvedev
The Asp299Gly polymorphism alters TLR4 signaling by interfering with recruitment of MyD88 and TRIF.
Journal of immunology (Baltimore, Md. : 1950) 2012;188(9):4506-15.
2012: Chiguang Feng; Chris D Geddes; Andrei E Medvedev; Quan M Nhu; Prasad Rallabhandi; Chang Song; Nicholas M Stamatos; Stefanie N Vogel; Melissa Whitford; Lei Zhang; Leah E Cole; Anatoliy I Dragan; Alan S Cross
Sialyl residues modulate LPS-mediated signaling through the Toll-like receptor 4 complex.
PloS one 2012;7(4):e32359.
2011: Yanbao Xiong; Andrei E Medvedev
Induction of endotoxin tolerance in vivo inhibits activation of IRAK4 and increases negative regulators IRAK-M, SHIP-1, and A20.
Journal of leukocyte biology 2011;90(6):1141-8.
2011: Fu Qiu; Marco Quevedo Diaz; Andrei I Chapoval; Amudhan Maniar; Andrei E Medvedev
Activation of cytokine-producing and antitumor activities of natural killer cells and macrophages by engagement of Toll-like and NOD-like receptors.
Innate immunity 2011;17(4):375-87.
2011: Yanbao Xiong; Fu Qiu; Wenji Piao; Chang Song; Larry M Wahl; Andrei E Medvedev
Endotoxin tolerance impairs IL-1 receptor-associated kinase (IRAK) 4 and TGF-beta-activated kinase 1 activation, K63-linked polyubiquitination and assembly of IRAK1, TNF receptor-associated factor 6, and IkappaB kinase gamma and increases A20 expression.
The Journal of biological chemistry 2011;286(10):7905-16.
2010: Marco A Quevedo Diaz; Chang Song; Yanbao Xiong; Haiyan Chen; Larry M Wahl; Suzana Radulovic; Andrei E Medvedev
Involvement of TLR2 and TLR4 in cell responses to Rickettsia akari.
Journal of leukocyte biology 2010;88(4):675-85.
2009: Wenji Piao; Chang Song; Haiyan Chen; Marco A Quevedo Diaz; Larry M Wahl; Katherine A Fitzgerald; Liwu Li; Andrei E Medvedev
Endotoxin tolerance dysregulates MyD88- and Toll/IL-1R domain-containing adapter inducing IFN-beta-dependent pathways and increases expression of negative regulators of TLR signaling.
Journal of leukocyte biology 2009;86(4):863-75.
2009: Joanna L Shoenfelt; Robert J Mitkus; Rolf Zeisler; Rabia O Spatz; Jonathan D Powell; Matthew J Fenton; Katherine S Squibb; Andrei E Medvedev
Involvement of TLR2 and TLR4 in inflammatory immune responses induced by fine and coarse ambient air particulate matter.
Journal of leukocyte biology 2009;86(2):303-12.
2009: Michelle H W Laird; Sang Hoon Rhee; Darren Perkins; Andrei E Medvedev; Wenji Piao; Matthew J Fenton; Stefanie N Vogel
TLR4/MyD88/PI3K interactions regulate TLR4 signaling.
Journal of leukocyte biology 2009;85(6):966-77.
2009: Andrei E Medvedev; Wenji Piao
Analysis of the functional role of Toll-like receptor-4 tyrosine phosphorylation.
Methods in molecular biology (Clifton, N.J.) 2009;517():145-67.
2008: Prasad Rallabhandi; Quan M Nhu; Vladimir Toshchakov; Wenji Piao; Andrei E Medvedev; Morley D Hollenberg; Alessio Fasano; Stefanie N Vogel
Analysis of proteinase-activated receptor 2 and TLR4 signal transduction: a novel paradigm for receptor cooperativity.
The Journal of biological chemistry 2008;283(36):24314-25.
2008: Wenji Piao; Chang Song; Haiyan Chen; Larry M Wahl; Katherine A Fitzgerald; Luke A O'Neill; Andrei E Medvedev
Tyrosine phosphorylation of MyD88 adapter-like (Mal) is critical for signal transduction and blocked in endotoxin tolerance.
The Journal of biological chemistry 2008;283(6):3109-19.
2007: Haiyan Chen; Mark J Cowan; Jeffrey D Hasday; Stefanie N Vogel; Andrei E Medvedev
Tobacco smoking inhibits expression of proinflammatory cytokines and activation of IL-1R-associated kinase, p38, and NF-kappaB in alveolar macrophages stimulated with TLR2 and TLR4 agonists.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(9):6097-106.
2007: Andrei E Medvedev; Wenji Piao; Joanna L Shoenfelt; Sang Hoon Rhee; Haiyan Chen; subhendu basu; Larry M Wahl; Matthew J Fenton; Stefanie N Vogel
Role of TLR4 tyrosine phosphorylation in signal transduction and endotoxin tolerance.
The Journal of biological chemistry 2007;282(22):16042-53.
2006: Prasad Rallabhandi; Jessica Bell; Marina S Boukhvalova; Andrei E Medvedev; Eva Lorenz; Moshe Arditi; Val G Hemming; Jorge C G Blanco; David M Segal; Stefanie N Vogel
Analysis of TLR4 polymorphic variants: new insights into TLR4/MD-2/CD14 stoichiometry, structure, and signaling.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(1):322-32.
2006: Andrei E Medvedev; Ian Sabroe; Jeffrey D Hasday; Stefanie N Vogel
Tolerance to microbial TLR ligands: molecular mechanisms and relevance to disease.
Journal of endotoxin research 2006;12(3):133-50.
2005: Andrei E Medvedev; Karen Thomas; Agnes A Awomoyi; Douglas B Kuhns; John Gallin; Xiaoxia Li; Stefanie N Vogel
Cutting edge: expression of IL-1 receptor-associated kinase-4 (IRAK-4) proteins with mutations identified in a patient with recurrent bacterial infections alters normal IRAK-4 interaction with components of the IL-1 receptor complex.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(11):6587-91.
2005: Stefanie N Vogel; Agnes A Awomoyi; Prasad Rallabhandi; Andrei E Medvedev
Mutations in TLR4 signaling that lead to increased susceptibility to infection in humans: an overview.
Journal of endotoxin research 2005;11(6):333-9.
2003: Andrei E Medvedev; Arnd Lentschat; Douglas B Kuhns; Jorge C G Blanco; Cindy A Salkowski; Shuling Zhang; Moshe Arditi; John Gallin; Stefanie N Vogel
Distinct mutations in IRAK-4 confer hyporesponsiveness to lipopolysaccharide and interleukin-1 in a patient with recurrent bacterial infections.
The Journal of experimental medicine 2003;198(4):521-31.
2003: Andrei E Medvedev; Stefanie N Vogel
Overexpression of CD14, TLR4, and MD-2 in HEK 293T cells does not prevent induction of in vitro endotoxin tolerance.
Journal of endotoxin research 2003;9(1):60-4.
2003: Marina A Dobrovolskaia; Andrei E Medvedev; Karen E Thomas; Natalia Cuesta; Vladimir Toshchakov; Tianbo Ren; M Joshua Cody; Suzanne M Michalek; Nancy R Rice; Stefanie N Vogel
Induction of in vitro reprogramming by Toll-like receptor (TLR)2 and TLR4 agonists in murine macrophages: effects of TLR "homotolerance" versus "heterotolerance" on NF-kappa B signaling pathway components.
Journal of immunology (Baltimore, Md. : 1950) 2003;170(1):508-19.
2002: Andrei E Medvedev; Arnd Lentschat; Larry M Wahl; Douglas T Golenbock; Stefanie N Vogel
Dysregulation of LPS-induced Toll-like receptor 4-MyD88 complex formation and IL-1 receptor-associated kinase 1 activation in endotoxin-tolerant cells.
Journal of immunology (Baltimore, Md. : 1950) 2002;169(9):5209-16.
2001: Andrei E Medvedev; Philipp Henneke; Andra B Schromm; Egil Lien; Robin R Ingalls; Matthew J Fenton; Douglas T Golenbock; Stefanie N Vogel
Induction of tolerance to lipopolysaccharide and mycobacterial components in Chinese hamster ovary/CD14 cells is not affected by overexpression of Toll-like receptors 2 or 4.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(4):2257-67.
2001: Emmanuelle Faure; Lisa Thomas; H Xu; Andrei E Medvedev; Ozlem Equils; Moshe Arditi
Bacterial lipopolysaccharide and IFN-gamma induce Toll-like receptor 2 and Toll-like receptor 4 expression in human endothelial cells: role of NF-kappa B activation.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(3):2018-24.
2000: Viktor Lakics; Andrei E Medvedev; S Okada; Stefanie N Vogel
Inhibition of LPS-induced cytokines by Bcl-xL in a murine macrophage cell line.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(5):2729-37.
2000: Andrei E Medvedev; KM Kopydlowski; Stefanie N Vogel
Inhibition of lipopolysaccharide-induced signal transduction in endotoxin-tolerized mouse macrophages: dysregulation of cytokine, chemokine, and toll-like receptor 2 and 4 gene expression.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(11):5564-74.
1999: Stefanie N Vogel; D Johnson; Pin-Yu Perera; Andrei E Medvedev; Line Larivière; Salman T Qureshi; Danielle Malo
Cutting edge: functional characterization of the effect of the C3H/HeJ defect in mice that lack an Lpsn gene: in vivo evidence for a dominant negative mutation.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(10):5666-70.
1999: Andrei E Medvedev; Jorge C G Blanco; N Qureshi; Stefanie N Vogel
Limited role of ceramide in lipopolysaccharide-mediated mitogen-activated protein kinase activation, transcription factor induction, and cytokine release.
The Journal of biological chemistry 1999;274(14):9342-50.
1998: Robin R Ingalls; Brian G Monks; R Savedra; W J Christ; RL Delude; Andrei E Medvedev; Terje Espevik; Douglas T Golenbock
CD11/CD18 and CD14 share a common lipid A signaling pathway.
Journal of immunology (Baltimore, Md. : 1950) 1998;161(10):5413-20.
1998: G Berntzen; Trude H Flo; Andrei E Medvedev; L Kilaas; Gudmund Skjåk-Braek; Anders Sundan; Terje Espevik
The tumor necrosis factor-inducing potency of lipopolysaccharide and uronic acid polymers is increased when they are covalently linked to particles.
Clinical and diagnostic laboratory immunology 1998;5(3):355-61.
1998: Andrei E Medvedev; Trude H Flo; Robin R Ingalls; Douglas T Golenbock; G Teti; Stefanie N Vogel; Terje Espevik
Involvement of CD14 and complement receptors CR3 and CR4 in nuclear factor-kappaB activation and TNF production induced by lipopolysaccharide and group B streptococcal cell walls.
Journal of immunology (Baltimore, Md. : 1950) 1998;160(9):4535-42.
1997: Andrei E Medvedev; AC Johnsen; J Haux; Bjørg Steinkjer; Kjartan Wollo Egeberg; D H Lynch; Anders Sundan; Terje Espevik
Regulation of Fas and Fas-ligand expression in NK cells by cytokines and the involvement of Fas-ligand in NK/LAK cell-mediated cytotoxicity.
Cytokine 1997;9(6):394-404.
1996: M Börset; Andrei E Medvedev; Anders Sundan; Terje Espevik
The role of the two TNF receptors in proliferation, NF-kappa B activation and discrimination between TNF and LT alpha signalling in the human myeloma cell line OH-2.
Cytokine 1996;8(6):430-8.
1996: Andrei E Medvedev; Terje Espevik; G Ranges; Anders Sundan
Distinct roles of the two tumor necrosis factor (TNF) receptors in modulating TNF and lymphotoxin alpha effects.
The Journal of biological chemistry 1996;271(16):9778-84.
1996: Andrei E Medvedev; A Laegreid; Anders Sundan; Terje Espevik
A non-competitive P55 TNF receptor antibody enhances the specific activity of lymphotoxin-alpha.
Scandinavian journal of immunology 1996;43(4):439-48.
1994: Andrei E Medvedev; Anders Sundan; Terje Espevik
Involvement of the tumor necrosis factor receptor p75 in mediating cytotoxicity and gene regulating activities.
European journal of immunology 1994;24(11):2842-9.
1994: A Laegreid; Andrei E Medvedev; U Nonstad; M P Bombara; G Ranges; Anders Sundan; Terje Espevik
Tumor necrosis factor receptor p75 mediates cell-specific activation of nuclear factor kappa B and induction of human cytomegalovirus enhancer.
The Journal of biological chemistry 1994;269(10):7785-91.
1992: Andrei E Medvedev; B B Fuks; N V Bovin; AE Zemliakov
[The immunomodulating activity of new muramyl dipeptide derivatives in vitro].
Biulleten' eksperimental'noĭ biologii i meditsiny 1992;114(12):626-8.
1991: Andrei E Medvedev; B B Fuks; K Iuriants; U Dostman; A Flegel'
[Study of the action of tumor cell immunosuppressive factors on the production of cytokines by lymphocytes and macrophages and the mitogenic activity of interleukin-2].
Biulleten' eksperimental'noĭ biologii i meditsiny 1991;111(5):523-5.
1989: Andrei E Medvedev; U Dostman; A Flegel'
[Effects of humoral factors of the mastocytoma P815 cells on the formation of allospecific killers in mixed culture of lymphocytes and their cytotoxic activity].
Biulleten' eksperimental'noĭ biologii i meditsiny 1989;108(8):224-6.
1989: Andrei E Medvedev; B B Fuks
[Humoral mechanisms of the membrano-toxic effects of mastocytoma P815 and leukemia EL4 cells].
Biulleten' eksperimental'noĭ biologii i meditsiny 1989;108(8):194-6.
1988: Andrei E Medvedev
[Humoral mechanisms of in vitro inhibition of mouse lymphocyte immunoreactivity by mastocytoma P815 cells].
Biulleten' eksperimental'noĭ biologii i meditsiny 1988;105(6):701-3.