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Katheryn Meek

Research Profile

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Brandi L Mahaney; Katheryn Meek; John A Tainer; Michal Hammel; Susan P Lees-Miller
XRCC4 and XLF form long helical protein filaments suitable for DNA end protection and alignment to facilitate DNA double strand break repair.
Katheryn Meek; Susan Lees-Miller; Mauro Modesti
N-terminal constraint activates the catalytic subunit of the DNA-dependent protein kinase in the absence of DNA or Ku.
Sunetra Roy; Alexandra Vergnes; Yao Xu; Yaping Yu; Sara N Andres; Murray S Junop; Susan Lees-Miller; Mauro Modesti; Jessica A Neal; Katheryn Meek
XRCC4's interaction with XLF is required for coding (but not signal) end joining.

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All Publications

2013: Brandi L Mahaney; Katheryn Meek; John A Tainer; Michal Hammel; Susan P Lees-Miller
XRCC4 and XLF form long helical protein filaments suitable for DNA end protection and alignment to facilitate DNA double strand break repair.
Biochemistry and cell biology = Biochimie et biologie cellulaire 2013;91(1):31-41.
2012: Katheryn Meek; Susan Lees-Miller; Mauro Modesti
N-terminal constraint activates the catalytic subunit of the DNA-dependent protein kinase in the absence of DNA or Ku.
Nucleic acids research 2012;40(7):2964-73.
2012: Sunetra Roy; Alexandra Vergnes; Yao Xu; Yaping Yu; Sara N Andres; Murray S Junop; Susan Lees-Miller; Mauro Modesti; Jessica A Neal; Katheryn Meek
XRCC4's interaction with XLF is required for coding (but not signal) end joining.
Nucleic acids research 2012;40(4):1684-94.
2011: Jessica A Neal; Katheryn Meek
Choosing the right path: does DNA-PK help make the decision?
Mutation research 2011;711(1-2):73-86.
2011: Jessica A Neal; Van Dang; Pauline Douglas; Marc S Wold; Susan Lees-Miller; Katheryn Meek
Inhibition of homologous recombination by DNA-dependent protein kinase requires kinase activity, is titratable, and is modulated by autophosphorylation.
Molecular and cellular biology 2011;31(8):1719-33.
2011: Atsushi Shibata; Sandro Conrad; Julie Birraux; Verena Geuting; Olivia Barton; Amani Ismail; Andreas Kakarougkas; Katheryn Meek; Gisela Taucher-Scholz; Markus Löbrich; Penny A Jeggo
Factors determining DNA double-strand break repair pathway choice in G2 phase.
The EMBO journal 2011;30(6):1079-92.
2010: Tina A Mueller; Katheryn Meek; Robert P Hausinger
Human AlkB homologue 1 (ABH1) exhibits DNA lyase activity at abasic sites.
DNA repair 2010;9(1):58-65.
2009: Katheryn Meek
New targets to translate DNA-PK signals.
Cell cycle (Georgetown, Tex.) 2009;8(23):3809.
2009: Katheryn Meek; Ari Jutkowitz; Lisa Allen; Jillian Glover; Erin Convery; Alisha Massa; Tom Mullaney; Bryden Stanley; Diana Rosenstein; Susan M Bailey; Cheri Johnson; George Georges
SCID dogs: similar transplant potential but distinct intra-uterine growth defects and premature replicative senescence compared with SCID mice.
Journal of immunology (Baltimore, Md. : 1950) 2009;183(4):2529-36.
2009: Eli S Williams; Rebekah Klingler; Brian Ponnaiya; Tanja Hardt; Evelin Schrock; Susan Lees-Miller; Katheryn Meek; Robert L Ullrich; Susan M Bailey
Telomere dysfunction and DNA-PKcs deficiency: characterization and consequence.
Cancer research 2009;69(5):2100-7.
2009: Brandi L Mahaney; Katheryn Meek; Susan Lees-Miller
Repair of ionizing radiation-induced DNA double-strand breaks by non-homologous end-joining.
The Biochemical journal 2009;417(3):639-50.
2008: Katheryn Meek; Van Dang; Susan Lees-Miller
DNA-PK: the means to justify the ends?
Advances in immunology 2008;99():33-58.
2007: Xiaoping Cui; Katheryn Meek
Linking double-stranded DNA breaks to the recombination activating gene complex directs repair to the nonhomologous end-joining pathway.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(43):17046-51.
2007: Barbara Corneo; Rebecca L Wendland; Ludovic Deriano; Xiaoping Cui; Isaac A Klein; Serre-Yu Wong; Suzzette Arnal; Abigail J Holub; Geoffrey R Weller; Bette A Pancake; Sundeep Shah; Vicky L Brandt; Katheryn Meek; David B Roth
Rag mutations reveal robust alternative end joining.
Nature 2007;449(7161):483-6.
2007: Katheryn Meek; Pauline Douglas; Xiaoping Cui; Qi Ding; Susan Lees-Miller
trans Autophosphorylation at DNA-dependent protein kinase's two major autophosphorylation site clusters facilitates end processing but not end joining.
Molecular and cellular biology 2007;27(10):3881-90.
2007: Pauline Douglas; Xiaoping Cui; Wesley D Block; Yaping Yu; Shikha Gupta; Qi Ding; Ruiqiong Ye; Nick Morrice; Susan Lees-Miller; Katheryn Meek
The DNA-dependent protein kinase catalytic subunit is phosphorylated in vivo on threonine 3950, a highly conserved amino acid in the protein kinase domain.
Molecular and cellular biology 2007;27(5):1581-91.
2005: Xiaoping Cui; Yaping Yu; Shikha Gupta; Young-Moon Cho; Susan Lees-Miller; Katheryn Meek
Autophosphorylation of DNA-dependent protein kinase regulates DNA end processing and may also alter double-strand break repair pathway choice.
Molecular and cellular biology 2005;25(24):10842-52.
2005: Pauline Douglas; Shikha Gupta; Nick Morrice; Katheryn Meek; Susan Lees-Miller
DNA-PK-dependent phosphorylation of Ku70/80 is not required for non-homologous end joining.
DNA repair 2005;4(9):1006-18.
2005: Erin Convery; Euy Kyun Shin; Qi Ding; Wei Wang; Pauline Douglas; Laurie S Davis; Jac A Nickoloff; Susan Lees-Miller; Katheryn Meek
Inhibition of homologous recombination by variants of the catalytic subunit of the DNA-dependent protein kinase (DNA-PKcs).
Proceedings of the National Academy of Sciences of the United States of America 2005;102(5):1345-50.
2005: Shikha Gupta; Katheryn Meek
The leucine rich region of DNA-PKcs contributes to its innate DNA affinity.
Nucleic acids research 2005;33(22):6972-81.
2004: Yeturu V R Reddy; Qi Ding; Susan Lees-Miller; Katheryn Meek; Dale A Ramsden
Non-homologous end joining requires that the DNA-PK complex undergo an autophosphorylation-dependent rearrangement at DNA ends.
The Journal of biological chemistry 2004;279(38):39408-13.
2004: Katheryn Meek; Shikha Gupta; Dale A Ramsden; Susan Lees-Miller
The DNA-dependent protein kinase: the director at the end.
Immunological reviews 2004;200():132-41.
2004: Thomas Wechsler; Benjamin P C Chen; Ryan Harper; Keiko Morotomi-Yano; Betty C B Huang; Katheryn Meek; James E Cleaver; David J Chen; Matthias Wabl
DNA-PKcs function regulated specifically by protein phosphatase 5.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(5):1247-52.
2004: Wesley D Block; Yaping Yu; Dennis Merkle; Jessica L Gifford; Qi Ding; Katheryn Meek; Susan Lees-Miller
Autophosphorylation-dependent remodeling of the DNA-dependent protein kinase catalytic subunit regulates ligation of DNA ends.
Nucleic acids research 2004;32(14):4351-7.
2004: Wesley D Block; Dennis Merkle; Katheryn Meek; Susan Lees-Miller
Selective inhibition of the DNA-dependent protein kinase (DNA-PK) by the radiosensitizing agent caffeine.
Nucleic acids research 2004;32(6):1967-72.
2003: Yaping Yu; Wei Wang; Qi Ding; Ruiqiong Ye; Dawn Chen; Dennis Merkle; David Schriemer; Katheryn Meek; Susan Lees-Miller
DNA-PK phosphorylation sites in XRCC4 are not required for survival after radiation or for V(D)J recombination.
DNA repair 2003;2(11):1239-52.
2003: Susan Lees-Miller; Katheryn Meek
Repair of DNA double strand breaks by non-homologous end joining.
Biochimie 2003;85(11):1161-73.
2003: Jennifer M Kilzer; Travis Stracker; Brett Beitzel; Katheryn Meek; Matthew Weitzman; Frederic D Bushman
Roles of host cell factors in circularization of retroviral dna.
Virology 2003;314(1):460-7.
2003: Qi Ding; Yeturu V R Reddy; Wei Wang; Timothy Woods; Pauline Douglas; Dale A Ramsden; Susan Lees-Miller; Katheryn Meek
Autophosphorylation of the catalytic subunit of the DNA-dependent protein kinase is required for efficient end processing during DNA double-strand break repair.
Molecular and cellular biology 2003;23(16):5836-48.
2002: Timothy Woods; Wei Wang; Erin Convery; a Errami; Malgorzata Z Zdzienicka; Katheryn Meek
A single amino acid substitution in DNA-PKcs explains the novel phenotype of the CHO mutant, XR-C2.
Nucleic acids research 2002;30(23):5120-8.
2002: Pauline Douglas; Gopal P Sapkota; Nick Morrice; Yaping Yu; ALI GOODARZI; Dennis Merkle; Katheryn Meek; Dario R Alessi; Susan Lees-Miller
Identification of in vitro and in vivo phosphorylation sites in the catalytic subunit of the DNA-dependent protein kinase.
The Biochemical journal 2002;368(Pt 1):243-51.
2002: Qi Ding; Lori Bramble; Vilma Yuzbasiyan-Gurkan; Thomas Bell; Katheryn Meek
DNA-PKcs mutations in dogs and horses: allele frequency and association with neoplasia.
Gene 2002;283(1-2):263-9.
2001: Katheryn Meek; L Kienker; C Dallas; Wei Wang; M J Dark; Patrick J Venta; Maryann L Huie; Rochelle Hirschhorn; Thomas Bell
SCID in Jack Russell terriers: a new animal model of DNA-PKcs deficiency.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(4):2142-50.
2000: L J Kienker; E K Shin; Katheryn Meek
Both V(D)J recombination and radioresistance require DNA-PK kinase activity, though minimal levels suffice for V(D)J recombination.
Nucleic acids research 2000;28(14):2752-61.
2000: EK Shin; Tonnie Rijkers; Albert Pastink; Katheryn Meek
Analyses of TCRB rearrangements substantiate a profound deficit in recombination signal sequence joining in SCID foals: implications for the role of DNA-dependent protein kinase in V(D)J recombination.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(3):1416-24.
1999: S Mickelsen; C Snyder; K Trujillo; MA Bogue; David B Roth; Katheryn Meek
Modulation of terminal deoxynucleotidyltransferase activity by the DNA-dependent protein kinase.
Journal of immunology (Baltimore, Md. : 1950) 1999;163(2):834-43.
1998: R Leber; R Wiler; LE Perryman; Katheryn Meek
Equine SCID: mechanistic analysis and comparison with murine SCID.
Veterinary immunology and immunopathology 1998;65(1):1-9.
1998: Lu Liu; Youn-Tae Kwak; Françoise Bex; LF García-Martínez; XH Li; Katheryn Meek; William Stratton Lane; Richard B Gaynor
DNA-dependent protein kinase phosphorylation of IkappaB alpha and IkappaB beta regulates NF-kappaB DNA binding properties.
Molecular and cellular biology 1998;18(7):4221-34.
1998: R Leber; T W Wise; R Mizuta; Katheryn Meek
The XRCC4 gene product is a target for and interacts with the DNA-dependent protein kinase.
The Journal of biological chemistry 1998;273(3):1794-801.
1997: EK Shin; LE Perryman; Katheryn Meek
Evaluation of a test for identification of Arabian horses heterozygous for the severe combined immunodeficiency trait.
Journal of the American Veterinary Medical Association 1997;211(10):1268-70.
1997: C Wang; MA Bogue; David B Roth; Katheryn Meek
Normal junctional diversification of immune receptors in p53-deficient mice.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(2):757-62.
1997: EK Shin; LE Perryman; Katheryn Meek
A kinase-negative mutation of DNA-PK(CS) in equine SCID results in defective coding and signal joint formation.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(8):3565-9.
1996: L F VanDyk; T W Wise; Bethany B Moore; Katheryn Meek
Immunoglobulin D(H) recombination signal sequence targeting: effect of D(H) coding and flanking regions and recombination partner.
Journal of immunology (Baltimore, Md. : 1950) 1996;157(9):4005-15.
1996: M D Jumper; K Fujita; P E Lipsky; Katheryn Meek
A CD30 responsive element in the germline epsilon promoter that is distinct from and inhibitory to the CD40 response element.
Molecular immunology 1996;33(11-12):965-72.
1995: R Wiler; R Leber; Bethany B Moore; L F VanDyk; L E Perryman; Katheryn Meek
Equine severe combined immunodeficiency: a defect in V(D)J recombination and DNA-dependent protein kinase activity.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(25):11485-9.
1995: M D Jumper; Y Nishioka; L S Davis; P E Lipsky; Katheryn Meek
Regulation of human B cell function by recombinant CD40 ligand and other TNF-related ligands.
Journal of immunology (Baltimore, Md. : 1950) 1995;155(5):2369-78.
1995: K Fujita; M D Jumper; Katheryn Meek; P E Lipsky
Evidence for a CD40 response element, distinct from the IL-4 response element, in the germline epsilon promoter.
International immunology 1995;7(9):1529-33.
1995: G R Brown; Katheryn Meek; Y Nishioka; Dwain L Thiele
CD27-CD27 ligand/CD70 interactions enhance alloantigen-induced proliferation and cytolytic activity in CD8+ T lymphocytes.
Journal of immunology (Baltimore, Md. : 1950) 1995;154(8):3686-95.
1995: Bethany B Moore; Katheryn Meek
Recombination potential of the human DIR elements.
Journal of immunology (Baltimore, Md. : 1950) 1995;154(5):2175-87.
1994: M D Jumper; J B Splawski; P E Lipsky; Katheryn Meek
Ligation of CD40 induces sterile transcripts of multiple Ig H chain isotypes in human B cells.
Journal of immunology (Baltimore, Md. : 1950) 1994;152(2):438-45.
1993: R N Jenkins; A Nikaein; A Zimmermann; Katheryn Meek; P E Lipsky
T cell receptor V beta gene bias in rheumatoid arthritis.
The Journal of clinical investigation 1993;92(6):2688-701.
1993: J Tassignon; M Brait; J Ismaili; Jacques Urbain; P Gottlieb; A Brown; Charles A Hasemann; J Donald Capra; Katheryn Meek
Molecular characterization of monoclonal CRIA-positive anti-arsonate antibodies derived from idiotype-negative mice bearing a light chain polymorphism.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(20):9508-12.
1992: L VanDyk; Katheryn Meek
Assembly of IgH CDR3: mechanism, regulation, and influence on antibody diversity.
International reviews of immunology 1992;8(2-3):123-33.
1991: Katheryn Meek; T Eversole; J Donald Capra
Conservation of the most JH proximal Ig VH gene segment (VHVI) throughout primate evolution.
Journal of immunology (Baltimore, Md. : 1950) 1991;146(7):2434-8.
1990: Katheryn Meek
Analysis of junctional diversity during B lymphocyte development.
Science (New York, N.Y.) 1990;250(4982):820-3.
1990: Katheryn Meek; G Rathbun; Luc Reininger; Jean-Claude Jaton; R Kofler; Philip W Tucker; J Donald Capra
Organization of the murine immunoglobulin VH complex: placement of two new VH families (VH10 and VH11) and analysis of VH family clustering and interdigitation.
Molecular immunology 1990;27(11):1073-81.
1990: Katheryn Meek; Masami Takei; Howard Dang; I Sanz; M J Dauphinée; J Donald Capra; Norman Talal
Anti-peptide antibodies detect a lupus-related interspecies idiotype that maps to H chain CDR2.
Journal of immunology (Baltimore, Md. : 1950) 1990;144(4):1375-81.
1990: Katheryn Meek; J Donald Capra
Structural implications of AB2s. Are novel D segments involved with anti-idiotypic specificity?
Chemical immunology 1990;48():30-48.
1989: Katheryn Meek; Charles A Hasemann; J Donald Capra
Novel rearrangements at the immunoglobulin D locus. Inversions and fusions add to IgH somatic diversity.
The Journal of experimental medicine 1989;170(1):39-57.
1989: Katheryn Meek; B Johansson; J Schulman; C Bona; J Donald Capra
Nucleotide changes in sequential variants of influenza virus hemagglutinin genes and molecular structures of corresponding monoclonal antibodies specific for each variant.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(12):4664-8.
1989: maurizio sollazzo; Charles A Hasemann; Katheryn Meek; Denis Glotz; J D Capra; M Zanetti
Molecular characterization of the VH region of murine autoantibodies from neonatal and adult BALB/c mice.
European journal of immunology 1989;19(3):453-7.
1989: Katheryn Meek; Charles A Hasemann; B Pollok; Sefik S Alkan; M Brait; Moncef Slaoui; Jacques Urbain; J Donald Capra
Structural characterization of antiidiotypic antibodies. Evidence that Ab2s are derived from the germline differently than Ab1s.
The Journal of experimental medicine 1989;169(2):519-33.
1988: H Kimura; R Cook; Katheryn Meek; M Umeda; E Ball; J D Capra; Donald M Marcus
Sequences of the VH and VL regions of murine monoclonal antibodies against 3-fucosyllactosamine.
Journal of immunology (Baltimore, Md. : 1950) 1988;140(4):1212-7.
1988: G Rathbun; I Sanz; Katheryn Meek; P Tucker; J Donald Capra
The molecular genetics of the arsonate idiotypic system of A/J mice.
Advances in immunology 1988;42():95-164.
1987: Michael J Taussig; D Kirk; M W Wang; S Ellis; Katheryn Meek; J Marvel; Jacques Urbain; R R Coombs
Idiotype-anti-idiotype interactions of VHIX-coded anti-progesterone and anti-arsonate antibodies. Comparison of passive haemagglutination and radioimmunoassays.
Scandinavian journal of immunology 1987;26(3):267-76.
1987: Katheryn Meek; I Sanz; G Rathbun; A Nisonoff; J Donald Capra
Identity of the V kappa 10-Ars-A gene segments of the A/J and BALB/c strains.
Proceedings of the National Academy of Sciences of the United States of America 1987;84(17):6244-8.
1987: jacqueline marvel; J Tassignon; M Brait; Katheryn Meek; Eric Milner; Muriel Moser; J Donald Capra; Jacques Urbain
The influence of V kappa gene polymorphism on the induction of silent idiotypes in the arsonate system.
Molecular immunology 1987;24(5):463-9.
1987: Katheryn Meek; D Jeske; S Alkan; Jacques Urbain; J Donald Capra
Structural characterization of syngeneic and allogeneic anti-idiotypic antibodies in the anti-arsonate system.
Monographs in allergy 1987;22():109-19.
1987: M Zanetti; Denis Glotz; J Rogers; Katheryn Meek; Charles A Hasemann
Autoimmune network.
Monographs in allergy 1987;22():46-56.
1984: Katheryn Meek; D Jeske; Moncef Slaoui; Oberdan Leo; Jacques Urbain; J Donald Capra
Complete amino acid sequence of heavy chain variable regions derived from two monoclonal anti-p-azophenylarsonate antibodies of BALB/c mice expressing the major cross-reactive idiotype of the A/J strain.
The Journal of experimental medicine 1984;160(4):1070-86.