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Flavio Meggio

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Publications

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Gander Stefan; Martin Dietmar; Hauri Simon; Moes Suzette; Poletto Giorgia; Pagano Mario A; Marin Oriano; Meggio Flavio; Jenoe Paul
A modified KESTREL search reveals a basophilic substrate consensus for the Saccharomyces cerevisiae Npr1 protein kinase.
Gianoncelli Alessandra; Cozza Giorgio; Orzeszko Andrzej; Meggio Flavio; Kazimierczuk Zygmunt; Pinna Lorenzo A
Tetraiodobenzimidazoles are potent inhibitors of protein kinase CK2.
Cozza Giorgio; Mazzorana Marco; Papinutto Elena; Bain Jenny; Elliott Matthew; di Maira Giovanni; Gianoncelli Alessandra; Pagano Mario A; Sarno Stefania; Ruzzene Maria; Battistutta Roberto; Meggio Flavio; Moro Stefano; Zagotto Giuseppe; Pinna Lorenzo A
Quinalizarin as a potent, selective and cell-permeable inhibitor of protein kinase CK2.

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All Publications

2009: Gander Stefan; Martin Dietmar; Hauri Simon; Moes Suzette; Poletto Giorgia; Pagano Mario A; Marin Oriano; Meggio Flavio; Jenoe Paul
A modified KESTREL search reveals a basophilic substrate consensus for the Saccharomyces cerevisiae Npr1 protein kinase.
Journal of proteome research 2009;8(11):5305-16.
2009: Gianoncelli Alessandra; Cozza Giorgio; Orzeszko Andrzej; Meggio Flavio; Kazimierczuk Zygmunt; Pinna Lorenzo A
Tetraiodobenzimidazoles are potent inhibitors of protein kinase CK2.
Bioorganic & medicinal chemistry 2009;17(20):7281-9.
2009: Cozza Giorgio; Mazzorana Marco; Papinutto Elena; Bain Jenny; Elliott Matthew; di Maira Giovanni; Gianoncelli Alessandra; Pagano Mario A; Sarno Stefania; Ruzzene Maria; Battistutta Roberto; Meggio Flavio; Moro Stefano; Zagotto Giuseppe; Pinna Lorenzo A
Quinalizarin as a potent, selective and cell-permeable inhibitor of protein kinase CK2.
The Biochemical journal 2009;421(3):387-95.
2008: Pagano Mario A; Bain Jenny; Kazimierczuk Zygmunt; Sarno Stefania; Ruzzene Maria; Di Maira Giovanni; Elliott Matthew; Orzeszko Andrzej; Cozza Giorgio; Meggio Flavio; Pinna Lorenzo A
The selectivity of inhibitors of protein kinase CK2: an update.
The Biochemical journal 2008;415(3):353-65.
2008: Cozza Giorgio; Gianoncelli Alessandra; Montopoli Monica; Caparrotta Laura; Venerando Andrea; Meggio Flavio; Pinna Lorenzo A; Zagotto Giuseppe; Moro Stefano
Identification of novel protein kinase CK1 delta (CK1delta) inhibitors through structure-based virtual screening.
Bioorganic & medicinal chemistry letters 2008;18(20):5672-5.
2008: Poletto Giorgia; Vilardell Jordi; Marin Oriano; Pagano Mario A; Cozza Giorgio; Sarno Stefania; Falqués Antoni; Itarte Emilio; Pinna Lorenzo A; Meggio Flavio
The regulatory beta subunit of protein kinase CK2 contributes to the recognition of the substrate consensus sequence. A study with an eIF2 beta-derived peptide.
Biochemistry 2008;47(32):8317-25.
2008: Pagano Mario A; Arrigoni Giorgio; Marin Oriano; Sarno Stefania; Meggio Flavio; Treharne Kate J; Mehta Anil; Pinna Lorenzo A
Modulation of protein kinase CK2 activity by fragments of CFTR encompassing F508 may reflect functional links with cystic fibrosis pathogenesis.
Biochemistry 2008;47(30):7925-36.
2008: Chilin Adriana; Battistutta Roberto; Bortolato Andrea; Cozza Giorgio; Zanatta Samuele; Poletto Giorgia; Mazzorana Marco; Zagotto Giuseppe; Uriarte Eugenio; Guiotto Adriano; Pinna Lorenzo A; Meggio Flavio; Moro Stefano
Coumarin as attractive casein kinase 2 (CK2) inhibitor scaffold: an integrate approach to elucidate the putative binding motif and explain structure-activity relationships.
Journal of medicinal chemistry 2008;51(4):752-9.
2007: Hemsley Matthew J; Mazzotta Gabriella M; Mason Moyra; Dissel Stephane; Toppo Stefano; Pagano Mario A; Sandrelli Federica; Meggio Flavio; Rosato Ezio; Costa Rodolfo; Tosatto Silvio C E
Linear motifs in the C-terminus of D. melanogaster cryptochrome.
Biochemical and biophysical research communications 2007;355(2):531-7.
2007: Pagano Mario A; Poletto Giorgia; Di Maira Giovanni; Cozza Giorgio; Ruzzene Maria; Sarno Stefania; Bain Jenny; Elliott Matthew; Moro Stefano; Zagotto Giuseppe; Meggio Flavio; Pinna Lorenzo A
Tetrabromocinnamic acid (TBCA) and related compounds represent a new class of specific protein kinase CK2 inhibitors.
Chembiochem : a European journal of chemical biology 2007;8(1):129-39.
2006: Pagano M A; Cesaro L; Meggio F; Pinna L A
Protein kinase CK2: a newcomer in the 'druggable kinome'.
Biochemical Society transactions 2006;34(Pt 6):1303-6.
2006: Salvi Mauro; Sarno Stefania; Marin Oriano; Meggio Flavio; Itarte Emilio; Pinna Lorenzo A
Discrimination between the activity of protein kinase CK2 holoenzyme and its catalytic subunits.
FEBS letters 2006;580(16):3948-52.
2006: Cozza Giorgio; Bonvini Paolo; Zorzi Elisa; Poletto Giorgia; Pagano Mario A; Sarno Stefania; Donella-Deana Arianna; Zagotto Giuseppe; Rosolen Angelo; Pinna Lorenzo A; Meggio Flavio; Moro Stefano
Identification of ellagic acid as potent inhibitor of protein kinase CK2: a successful example of a virtual screening application.
Journal of medicinal chemistry 2006;49(8):2363-6.
2005: Bustos Victor H; Marin Oriano; Meggio Flavio; Cesaro Luca; Allende Catherine C; Allende Jorge E; Pinna Lorenzo A
Generation of protein kinase Ck1alpha mutants which discriminate between canonical and non-canonical substrates.
The Biochemical journal 2005;391(Pt 2):417-24.
2005: Bach Stéphane; Knockaert Marie; Reinhardt Jens; Lozach Olivier; Schmitt Sophie; Baratte Blandine; Koken Marcel; Coburn Stephen P; Tang Lin; Jiang Tao; Liang Dong-Cai; Galons Hervé; Dierick Jean-Francois; Pinna Lorenzo A; Meggio Flavio; Totzke Frank; Schächtele Christoph; Lerman Andrea S; Carnero Amancio; Wan Yongqin; Gray Nathanael; Meijer Laurent
Roscovitine targets, protein kinases and pyridoxal kinase.
The Journal of biological chemistry 2005;280(35):31208-19.
2005: Ferrari Stefano; Marin Oriano; Pagano Mario A; Meggio Flavio; Hess Daniel; El-Shemerly Mahmoud; Krystyniak Agnieszka; Pinna Lorenzo A
Aurora-A site specificity: a study with synthetic peptide substrates.
The Biochemical journal 2005;390(Pt 1):293-302.
2005: Sarno Stefania; Ruzzene Maria; Frascella Pietrogiulio; Pagano Mario A; Meggio Flavio; Zambon Alfonso; Mazzorana Marco; Di Maira Giovanni; Lucchini Vittorio; Pinna Lorenzo A
Development and exploitation of CK2 inhibitors.
Molecular and cellular biochemistry 2005;274(1-2):69-76.
2005: Llorens Franc; Sarno Stefania; Sarró Eduard; Duarri Anna; Roher Nerea; Meggio Flavio; Plana Maria; Pinna Lorenzo A; Itarte Emilio
Cross talk between protein kinase CK2 and eukaryotic translation initiation factor eIF2beta subunit.
Molecular and cellular biochemistry 2005;274(1-2):53-61.
2005: Pagano Mario A; Sarno Stefania; Poletto Giorgia; Cozza Giorgio; Pinna Lorenzo A; Meggio Flavio
Autophosphorylation at the regulatory beta subunit reflects the supramolecular organization of protein kinase CK2.
Molecular and cellular biochemistry 2005;274(1-2):23-9.
2004: Pagano Mario A; Andrzejewska Mariola; Ruzzene Maria; Sarno Stefania; Cesaro Luca; Bain Jenny; Elliott Matthew; Meggio Flavio; Kazimierczuk Zygmunt; Pinna Lorenzo A
Optimization of protein kinase CK2 inhibitors derived from 4,5,6,7-tetrabromobenzimidazole.
Journal of medicinal chemistry 2004;47(25):6239-47.
2004: Meggio Flavio; Pagano Mario A; Moro Stefano; Zagotto Giuseppe; Ruzzene Maria; Sarno Stefania; Cozza Giorgio; Bain Jenny; Elliott Matthew; Deana Arianna Donella; Brunati Anna Maria; Pinna Lorenzo A
Inhibition of protein kinase CK2 by condensed polyphenolic derivatives. An in vitro and in vivo study.
Biochemistry 2004;43(40):12931-6.
2004: Arrigoni Giorgio; Marin Oriano; Pagano Mario A; Settimo Luca; Paolin Bruno; Meggio Flavio; Pinna Lorenzo A
Phosphorylation of calmodulin fragments by protein kinase CK2. Mechanistic aspects and structural consequences.
Biochemistry 2004;43(40):12788-98.
2004: Pagano Mario A; Meggio Flavio; Ruzzene Maria; Andrzejewska Mariola; Kazimierczuk Zygmunt; Pinna Lorenzo A
2-Dimethylamino-4,5,6,7-tetrabromo-1H-benzimidazole: a novel powerful and selective inhibitor of protein kinase CK2.
Biochemical and biophysical research communications 2004;321(4):1040-4.
2004: Loizou Joanna I; El-Khamisy Sherif F; Zlatanou Anastasia; Moore David J; Chan Douglas W; Qin Jun; Sarno Stefania; Meggio Flavio; Pinna Lorenzo A; Caldecott Keith W
The protein kinase CK2 facilitates repair of chromosomal DNA single-strand breaks.
Cell 2004;117(1):17-28.
2003: Llorens Franc; Roher Nerea; Miró Francesc A; Sarno Stefania; Ruiz F Xavier; Meggio Flavio; Plana Maria; Pinna Lorenzo A; Itarte Emilio
Eukaryotic translation-initiation factor eIF2beta binds to protein kinase CK2: effects on CK2alpha activity.
The Biochemical journal 2003;375(Pt 3):623-31.
2003: Andrzejewska Mariola; Pagano Mario A; Meggio Flavio; Brunati Anna Maria; Kazimierczuk Zygmunt
Polyhalogenobenzimidazoles: synthesis and their inhibitory activity against casein kinases.
Bioorganic & medicinal chemistry 2003;11(18):3997-4002.
2003: Marin Oriano; Bustos Victor H; Cesaro Luca; Meggio Flavio; Pagano Mario A; Antonelli Marcelo; Allende Catherine C; Pinna Lorenzo A; Allende Jorge E
A noncanonical sequence phosphorylated by casein kinase 1 in beta-catenin may play a role in casein kinase 1 targeting of important signaling proteins.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(18):10193-200.
2003: Sarno Stefania; de Moliner Erika; Ruzzene Maria; Pagano Mario A; Battistutta Roberto; Bain Jenny; Fabbro Doriano; Schoepfer Joseph; Elliott Matthew; Furet Pascal; Meggio Flavio; Zanotti Giuseppe; Pinna Lorenzo A
Biochemical and three-dimensional-structural study of the specific inhibition of protein kinase CK2 by [5-oxo-5,6-dihydroindolo-(1,2-a)quinazolin-7-yl]acetic acid (IQA).
The Biochemical journal 2003;374(Pt 3):639-46.
2003: Meggio Flavio; Pinna Lorenzo A
One-thousand-and-one substrates of protein kinase CK2?
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2003;17(3):349-68.
2002: Navazio Lorella; Moscatiello Roberto; Bellincampi Daniela; Baldan Barbara; Meggio Flavio; Brini Marisa; Bowler Chris; Mariani Paola
The role of calcium in oligogalacturonide-activated signalling in soybean cells.
Planta 2002;215(4):596-605.
2002: Semplici Francesca; Meggio Flavio; Pinna Lorenzo A; Oliviero Salvatore
CK2-dependent phosphorylation of the E2 ubiquitin conjugating enzyme UBC3B induces its interaction with beta-TrCP and enhances beta-catenin degradation.
Oncogene 2002;21(25):3978-87.
2002: Sarno Stefania; Moro Stefano; Meggio Flavio; Zagotto Giuseppe; Dal Ben Diego; Ghisellini Paola; Battistutta Roberto; Zanotti Giuseppe; Pinna Lorenzo A
Toward the rational design of protein kinase casein kinase-2 inhibitors.
Pharmacology & therapeutics 2002;93(2-3):159-68.
2002: Marin Oriano; Burzio Veronica; Boschetti Marco; Meggio Flavio; Allende Catherine C; Allende Jorge E; Pinna Lorenzo A
Structural features underlying the multisite phosphorylation of the A domain of the NF-AT4 transcription factor by protein kinase CK1.
Biochemistry 2002;41(2):618-27.
2001: Meggio F; Marin O; Boschetti M; Sarno S; Pinna L A
HIV-1 Rev transactivator: a beta-subunit directed substrate and effector of protein kinase CK2.
Molecular and cellular biochemistry 2001;227(1-2):145-51.
2001: Roher N; Sarno S; Miró F; Ruzzene M; Llorens F; Meggio F; Itarte E; Pinna L A; Plana M
The carboxy-terminal domain of Grp94 binds to protein kinase CK2 alpha but not to CK2 holoenzyme.
FEBS letters 2001;505(1):42-6.
2001: Brunati A M; Marin O; Folda A; Meggio F; Pinna L A
Possible implication of the Golgi apparatus casein kinase in the phosphorylation of vesicle docking protein p115 Ser-940: a study with peptide substrates.
Biochemical and biophysical research communications 2001;284(3):817-22.
2001: Sarno S; Reddy H; Meggio F; Ruzzene M; Davies S P; Donella-Deana A; Shugar D; Pinna L A
Selectivity of 4,5,6,7-tetrabromobenzotriazole, an ATP site-directed inhibitor of protein kinase CK2 ('casein kinase-2').
FEBS letters 2001;496(1):44-8.
2000: D'Agostino D M; Ferro T; Zotti L; Meggio F; Pinna L A; Chieco-Bianchi L; Ciminale V
Identification of a domain in human immunodeficiency virus type 1 rev that is required for functional activity and modulates association with subnuclear compartments containing splicing factor SC35.
Journal of virology 2000;74(24):11899-910.
2000: Meggio F; Negro A; Sarno S; Ruzzene M; Bertoli A; Sorgato M C; Pinna L A
Bovine prion protein as a modulator of protein kinase CK2.
The Biochemical journal 2000;352 Pt 1():191-6.
2000: Sarno S; Marin O; Boschetti M; Pagano M A; Meggio F; Pinna L A
Cooperative modulation of protein kinase CK2 by separate domains of its regulatory beta-subunit.
Biochemistry 2000;39(40):12324-9.
2000: Marin O; Sarno S; Boschetti M; Pagano M A; Meggio F; Ciminale V; D'Agostino D M; Pinna L A
Unique features of HIV-1 Rev protein phosphorylation by protein kinase CK2 ('casein kinase-2').
FEBS letters 2000;481(1):63-7.
2000: Negro A; Meggio F; Bertoli A; Battistutta R; Sorgato M C; Pinna L A
Susceptibility of the prion protein to enzymic phosphorylation.
Biochemical and biophysical research communications 2000;271(2):337-41.
2000: Meggio F; Ruzzene M; Sarno S; Pagano M A; Pinna L A
pCMB treatment reveals the essential role of cysteinyl residues in conferring functional competence to the regulatory subunit of protein kinase CK2.
Biochemical and biophysical research communications 2000;267(1):427-32.
1999: Marin O; Meggio F; Sarno S; Cesaro L; Pagano M A; Pinna L A
Tyrosine versus serine/threonine phosphorylation by protein kinase casein kinase-2. A study with peptide substrates derived from immunophilin Fpr3.
The Journal of biological chemistry 1999;274(41):29260-5.
1999: Cordenonsi M; Turco F; D'atri F; Hammar E; Martinucci G; Meggio F; Citi S
Xenopus laevis occludin. Identification of in vitro phosphorylation sites by protein kinase CK2 and association with cingulin.
European journal of biochemistry / FEBS 1999;264(2):374-84.
1999: Pulgar V; Marin O; Meggio F; Allende C C; Allende J E; Pinna L A
Optimal sequences for non-phosphate-directed phosphorylation by protein kinase CK1 (casein kinase-1)--a re-evaluation.
European journal of biochemistry / FEBS 1999;260(2):520-6.
1999: Marin O; Meggio F; Pinna L A
Structural features underlying the unusual mode of calmodulin phosphorylation by protein kinase CK2: A study with synthetic calmodulin fragments.
Biochemical and biophysical research communications 1999;256(2):442-6.
1999: Meggio F; Marin O; Sarno S; Pinna L A
Functional analysis of CK2beta-derived synthetic fragments.
Molecular and cellular biochemistry 1999;191(1-2):35-42.
1998: Sarno S; Marin O; Ghisellini P; Meggio F; Pinna L A
Biochemical evidence that the N-terminal segments of the alpha subunit and the beta subunit play interchangeable roles in the activation of protein kinase CK2.
FEBS letters 1998;441(1):29-33.
1998: Orlandini M; Semplici F; Ferruzzi R; Meggio F; Pinna L A; Oliviero S
Protein kinase CK2alpha' is induced by serum as a delayed early gene and cooperates with Ha-ras in fibroblast transformation.
The Journal of biological chemistry 1998;273(33):21291-7.
1998: Navazio L; Nardi M C; Pancaldi S; Dainese P; Baldan B; Fitchette-Lainé A C; Faye L; Meggio F; Martin W; Mariani P
Functional conservation of calreticulin in Euglena gracilis.
The Journal of eukaryotic microbiology 1998;45(3):307-13.
1997: Cordenonsi M; Mazzon E; De Rigo L; Baraldo S; Meggio F; Citi S
Occludin dephosphorylation in early development of Xenopus laevis.
Journal of cell science 1997;110 ( Pt 24)():3131-9.
1997: Sarno S; Vaglio P; Marin O; Meggio F; Issinger O G; Pinna L A
Basic residues in the 74-83 and 191-198 segments of protein kinase CK2 catalytic subunit are implicated in negative but not in positive regulation by the beta-subunit.
European journal of biochemistry / FEBS 1997;248(2):290-5.
1997: Marin O; Meggio F; Sarno S; Pinna L A
Physical dissection of the structural elements responsible for regulatory properties and intersubunit interactions of protein kinase CK2 beta-subunit.
Biochemistry 1997;36(23):7192-8.
1997: Pinna L A; Meggio F
Protein kinase CK2 ("casein kinase-2") and its implication in cell division and proliferation.
Progress in cell cycle research 1997;3():77-97.
1996: Marin O; Meggio F; Perich J W; Pinna L A
Phosphotyrosine specifies the phosphorylation by protein kinase CK2 of a peptide reproducing the activation loop of the insulin receptor protein tyrosine kinase.
The international journal of biochemistry & cell biology 1996;28(9):999-1005.
1996: Meggio F; D'Agostino D M; Ciminale V; Chieco-Bianchi L; Pinna L A
Phosphorylation of HIV-1 Rev protein: implication of protein kinase CK2 and pro-directed kinases.
Biochemical and biophysical research communications 1996;226(2):547-54.
1996: Sarno S; Vaglio P; Meggio F; Issinger O G; Pinna L A
Protein kinase CK2 mutants defective in substrate recognition. Purification and kinetic analysis.
The Journal of biological chemistry 1996;271(18):10595-601.
1996: Baldan B; Navazio L; Friso A; Mariani P; Meggio F
Plant calreticulin is specifically and efficiently phosphorylated by protein kinase CK2.
Biochemical and biophysical research communications 1996;221(3):498-502.
1996: Lasa-Benito M; Marin O; Meggio F; Pinna L A
Golgi apparatus mammary gland casein kinase: monitoring by a specific peptide substrate and definition of specificity determinants.
FEBS letters 1996;382(1-2):149-52.
1996: Perich J W; Meggio F; Pinna L A
Solid phase synthesis of pp60src-related phosphopeptides via 'global' phosphorylation and their use as substrates for enzymatic phosphorylation by casein kinase-2.
Bioorganic & medicinal chemistry 1996;4(2):143-50.
1996: Vaglio P; Sarno S; Marin O; Meggio F; Issinger O G; Pinna L A
Mapping the residues of protein kinase CK2 alpha subunit responsible for responsiveness to polyanionic inhibitors.
FEBS letters 1996;380(1-2):25-8.
1995: Meggio F; Donella Deana A; Ruzzene M; Brunati A M; Cesaro L; Guerra B; Meyer T; Mett H; Fabbro D; Furet P
Different susceptibility of protein kinases to staurosporine inhibition. Kinetic studies and molecular bases for the resistance of protein kinase CK2.
European journal of biochemistry / FEBS 1995;234(1):317-22.
1995: Meggio F; Boldyreff B; Marin O; Issinger O G; Pinna L A
Phosphorylation and activation of protein kinase CK2 by p34cdc2 are independent events.
European journal of biochemistry / FEBS 1995;230(3):1025-31.
1995: Bozzetti M P; Massari S; Finelli P; Meggio F; Pinna L A; Boldyreff B; Issinger O G; Palumbo G; Ciriaco C; Bonaccorsi S
The Ste locus, a component of the parasitic cry-Ste system of Drosophila melanogaster, encodes a protein that forms crystals in primary spermatocytes and mimics properties of the beta subunit of casein kinase 2.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(13):6067-71.
1995: Marin O; Meggio F; Boldyreff B; Issinger O G; Pinna L A
Dissection of the dual function of the beta-subunit of protein kinase CK2 ('casein kinase-2'): a synthetic peptide reproducing the carboxyl-terminal domain mimicks the positive but not the negative effects of the whole protein.
FEBS letters 1995;363(1-2):111-4.
1995: Sarno S; Boldyreff B; Marin O; Guerra B; Meggio F; Issinger O G; Pinna L A
Mapping the residues of protein kinase CK2 implicated in substrate recognition: mutagenesis of conserved basic residues in the alpha-subunit.
Biochemical and biophysical research communications 1995;206(1):171-9.
1994: Dobrowolska G; Meggio F; Marin O; Lozeman F J; Li D; Pinna L A; Krebs E G
Substrate recognition by casein kinase-II: the role of histidine-160.
FEBS letters 1994;355(3):237-41.
1994: Marin O; Meggio F; Sarno S; Andretta M; Pinna L A
Phosphorylation of synthetic fragments of inhibitor-2 of protein phosphatase-1 by casein kinase-1 and -2. Evidence that phosphorylated residues are not strictly required for efficient targeting by casein kinase-1.
European journal of biochemistry / FEBS 1994;223(2):647-53.
1994: Meggio F; Boldyreff B; Issinger O G; Pinna L A
Casein kinase 2 down-regulation and activation by polybasic peptides are mediated by acidic residues in the 55-64 region of the beta-subunit. A study with calmodulin as phosphorylatable substrate.
Biochemistry 1994;33(14):4336-42.
1994: Marin O; Meggio F; Pinna L A
Design and synthesis of two new peptide substrates for the specific and sensitive monitoring of casein kinases-1 and -2.
Biochemical and biophysical research communications 1994;198(3):898-905.
1994: Boldyreff B; Meggio F; Pinna L A; Issinger O G
Efficient autophosphorylation and phosphorylation of the beta-subunit by casein kinase-2 require the integrity of an acidic cluster 50 residues downstream from the phosphoacceptor site.
The Journal of biological chemistry 1994;269(7):4827-31.
1994: Salvatori S; Furlan S; Meggio F
Dual role of calsequestrin as substrate and inhibitor of casein kinase-1 and casein kinase-2.
Biochemical and biophysical research communications 1994;198(1):144-9.
1994: Meggio F; Marin O; Pinna L A
Substrate specificity of protein kinase CK2.
Cellular & molecular biology research 1994;40(5-6):401-9.
1994: Boldyreff B; Meggio F; Pinna L A; Issinger O G
Protein kinase CK2 structure-function relationship: effects of the beta subunit on reconstitution and activity.
Cellular & molecular biology research 1994;40(5-6):391-9.
1993: Boldyreff B; Meggio F; Pinna L A; Issinger O G
Reconstitution of normal and hyperactivated forms of casein kinase-2 by variably mutated beta-subunits.
Biochemistry 1993;32(47):12672-7.
1993: Perich J W; Meggio F; Valerio R M; Johns R B; Pinna L A; Reynolds E C
The synthesis and use of pp60src-related peptides and phosphopeptides as substrates for enzymatic phosphorylation studies.
Bioorganic & medicinal chemistry 1993;1(5):381-8.
1993: Sarno S; Marin O; Meggio F; Pinna L A
Polyamines as negative regulators of casein kinase-2: the phosphorylation of calmodulin triggered by polylysine and by the alpha[66-86] peptide is prevented by spermine.
Biochemical and biophysical research communications 1993;194(1):83-90.
1993: Meggio F; Boldyreff B; Issinger O G; Pinna L A
The autophosphorylation and p34cdc2 phosphorylation sites of casein kinase-2 beta-subunit are not essential for reconstituting the fully-active heterotetrameric holoenzyme.
Biochimica et biophysica acta 1993;1164(2):223-5.
1993: Boldyreff B; Meggio F; Dobrowolska G; Pinna L A; Issinger O G
Expression and characterization of a recombinant maize CK-2 alpha subunit.
Biochimica et biophysica acta 1993;1173(1):32-8.
1992: Boldyreff B; Meggio F; Pinna L A; Issinger O G
Casein kinase-2 structure-function relationship: creation of a set of mutants of the beta subunit that variably surrogate the wildtype beta subunit function.
Biochemical and biophysical research communications 1992;188(1):228-34.
1992: Perich J W; Meggio F; Reynolds E C; Marin O; Pinna L A
Role of phosphorylated aminoacyl residues in generating atypical consensus sequences which are recognized by casein kinase-2 but not by casein kinase-1.
Biochemistry 1992;31(25):5893-7.
1992: Meggio F; Boldyreff B; Marin O; Marchiori F; Perich J W; Issinger O G; Pinna L A
The effect of polylysine on casein-kinase-2 activity is influenced by both the structure of the protein/peptide substrates and the subunit composition of the enzyme.
European journal of biochemistry / FEBS 1992;205(3):939-45.
1992: Marin O; Meggio F; Draetta G; Pinna L A
The consensus sequences for cdc2 kinase and for casein kinase-2 are mutually incompatible. A study with peptides derived from the beta-subunit of casein kinase-2.
FEBS letters 1992;301(1):111-4.
1992: Dobrowolska G; Meggio F; Szczegielniak J; Muszynska G; Pinna L A
Purification and characterization of maize seedling casein kinase IIB, a monomeric enzyme immunologically related to the alpha subunit of animal casein kinase-2.
European journal of biochemistry / FEBS 1992;204(1):299-303.
1992: Meggio F; Boldyreff B; Marin O; Pinna L A; Issinger O G
Role of the beta subunit of casein kinase-2 on the stability and specificity of the recombinant reconstituted holoenzyme.
European journal of biochemistry / FEBS 1992;204(1):293-7.
1992: Meggio F; Perich J W; Marin O; Pinna L A
The comparative efficiencies of the Ser(P)-, Thr(P)- and Tyr(P)-residues as specificity determinants for casein kinase-1.
Biochemical and biophysical research communications 1992;182(3):1460-5.
1991: Meggio F; Perich J W; Reynolds E C; Pinna L A
A synthetic beta-casein phosphopeptide and analogues as model substrates for casein kinase-1, a ubiquitous, phosphate directed protein kinase.
FEBS letters 1991;283(2):303-6.
1991: Meggio F; Perich J W; Reynolds E C; Pinna L A
Phosphotyrosine as a specificity determinant for casein kinase-2, a growth related Ser/Thr-specific protein kinase.
FEBS letters 1991;279(2):307-9.
1990: Marin O; Calderan A; Ruzza P; Borin G; Meggio F; Grankowski N; Marchiori F
Synthetic peptides including acidic clusters as substrates of yeast casein kinase-2.
International journal of peptide and protein research 1990;36(4):374-80.
1990: Perich J W; Meggio F; Kitas E A; Valerio R M; Johns R B; Pinna L A
Phosphorylation of src-phosphopeptides by casein kinases-1 and -2: favourable effect of phosphotyrosine.
Biochemical and biophysical research communications 1990;170(2):635-42.
1990: Meggio F; Shugar D; Pinna L A
Ribofuranosyl-benzimidazole derivatives as inhibitors of casein kinase-2 and casein kinase-1.
European journal of biochemistry / FEBS 1990;187(1):89-94.
1989: Meggio F; Perich J W; Meyer H E; Hoffmann-Posorske E; Lennon D P; Johns R B; Pinna L A
Synthetic fragments of beta-casein as model substrates for liver and mammary gland casein kinases.
European journal of biochemistry / FEBS 1989;186(3):459-64.
1989: Dobrowolska G; Meggio F; Marchiori F; Pinna L A
Specificity determinants of maize casein kinase-IIB are related to but distinct from those of rat liver casein kinase-2.
Biochimica et biophysica acta 1989;1010(2):274-7.
1989: Meggio F; Pinna L A
Random tyrosine and glutamic acid-containing polymers are very powerful inhibitors of casein kinase-2.
Biochimica et biophysica acta 1989;1010(1):128-30.
1988: Meggio F; Boulton A P; Marchiori F; Borin G; Lennon D P; Calderan A; Pinna L A
Substrate-specificity determinants for a membrane-bound casein kinase of lactating mammary gland. A study with synthetic peptides.
European journal of biochemistry / FEBS 1988;177(2):281-4.
1988: Marchiori F; Meggio F; Marin O; Borin G; Calderan A; Ruzza P; Pinna L A
Synthetic peptide substrates for casein kinase 2. Assessment of minimum structural requirements for phosphorylation.
Biochimica et biophysica acta 1988;971(3):332-8.
1988: Meggio F; Perich J W; Johns R B; Pinna L A
Partially dephosphorylated phosphopeptide AcSer(P)-Ser(P)-Ser(P) is an excellent substrate for casein kinase-2.
FEBS letters 1988;237(1-2):225-8.
1988: Meggio F; Pinna L A
Phosphorylation of phosvitin by casein kinase-2 provides the evidence that phosphoserines can replace carboxylic amino acids as specificity determinants.
Biochimica et biophysica acta 1988;971(2):227-31.
1986: Marin O; Meggio F; Marchiori F; Borin G; Pinna L A
Site specificity of casein kinase-2 (TS) from rat liver cytosol. A study with model peptide substrates.
European journal of biochemistry / FEBS 1986;160(2):239-44.
1986: Meggio F; Grankowski N; Kudlicki W; Szyszka R; Gasior E; Pinna L A
Structure and properties of casein kinase-2 from Saccharomyces cerevisiae. A comparison with the liver enzyme.
European journal of biochemistry / FEBS 1986;159(1):31-8.
1984: Meggio F; Marchiori F; Borin G; Chessa G; Pinna L A
Synthetic peptides including acidic clusters as substrates and inhibitors of rat liver casein kinase TS (type-2).
The Journal of biological chemistry 1984;259(23):14576-9.
1984: Pinna L A; Meggio F; Marchiori F; Borin G
Opposite and mutually incompatible structural requirements of type-2 casein kinase and cAMP-dependent protein kinase as visualized with synthetic peptide substrates.
FEBS letters 1984;171(2):211-4.
1984: Meggio F; Brunati A M; Donella-Deana A; Pinna L A
Detection of type-2 casein kinase and its endogenous substrates in the components of the microsomal fraction of rat liver.
European journal of biochemistry / FEBS 1984;138(2):379-85.
1983: Chessa G; Borin G; Marchiori F; Meggio F; Brunati A M; Pinna L A
Synthetic peptides reproducing the site phosphorylated by cAMP-dependent protein kinase in protein phosphatase inhibitor-1. Effect of structural modifications on the phosphorylation efficiency.
European journal of biochemistry / FEBS 1983;135(3):609-14.
1983: Meggio F; Pinna L A; Marchiori F; Borin G
Polyglutamyl peptides: a new class of inhibitors of type-2 casein kinases.
FEBS letters 1983;162(2):235-8.
1982: Meggio F; Donella Deana A; Brunati A M; Pinna L A
Inhibition of rat liver cytosol casein kinases by heparin.
FEBS letters 1982;141(2):257-62.
1981: Meggio F; Chessa G; Borin G; Pinna L A; Marchiori F
Synthetic fragments of protamines as model substrates for rat liver cyclic AMP-dependent protein kinase.
Biochimica et biophysica acta 1981;662(1):94-101.

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