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Ian Megson

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Gabriele Montanaro; Barbara Rolando; Adriano G Rossi; Christopher D Lucas; Ian L Megson; Massimo Bertinaria; David A Dorward; Roberta Fruttero; Alberto Gasco
Novel R-roscovitine NO-donor hybrid compounds as potential pro-resolution of inflammation agents.
Qingzhi Zhang; Agnieszka Kulczynska; Ian L Megson; David J Webb; Nigel P Botting
A new class of NO-donor pro-drugs triggered by γ-glutamyl transpeptidase with potential for reno-selective vasodilatation.
Jeremy P Langrish; Ian L Megson; Stefan Barath; Scott Blackwell; Anders Blomberg; Jenny Bosson; Ala Muala; David E Newby; Jamshid Pourazar; Thomas Sandström; Stefan Söderberg; Andrew Treweeke; Jon Unosson; Nicholas L Mills
Altered nitric oxide bioavailability contributes to diesel exhaust inhalation-induced cardiovascular dysfunction in man.

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2013: Gabriele Montanaro; Barbara Rolando; Adriano G Rossi; Christopher D Lucas; Ian L Megson; Massimo Bertinaria; David A Dorward; Roberta Fruttero; Alberto Gasco
Novel R-roscovitine NO-donor hybrid compounds as potential pro-resolution of inflammation agents.
Bioorganic & medicinal chemistry 2013;21(7):2107-16.
2013: Qingzhi Zhang; Agnieszka Kulczynska; Ian L Megson; David J Webb; Nigel P Botting
A new class of NO-donor pro-drugs triggered by γ-glutamyl transpeptidase with potential for reno-selective vasodilatation.
Chemical communications (Cambridge, England) 2013;49(14):1389-91.
2013: Jeremy P Langrish; Ian L Megson; Stefan Barath; Scott Blackwell; Anders Blomberg; Jenny Bosson; Ala Muala; David E Newby; Jamshid Pourazar; Thomas Sandström; Stefan Söderberg; Andrew Treweeke; Jon Unosson; Nicholas L Mills
Altered nitric oxide bioavailability contributes to diesel exhaust inhalation-induced cardiovascular dysfunction in man.
Journal of the American Heart Association 2013;2(1):e004309.
2013: Lorna Halley; Neil McNamara; Ian L Megson; Mary K Doherty; Andy Gadja; Jun Wei
Search for schizophrenia susceptibility variants at the HLA-DRB1 locus among a British population.
Immunogenetics 2013;65(1):1-7.
2012: Phoebe K Allan; Karena W Chapman; Guy De Weireld; Joseph A Hriljac; Ian L Megson; M Infas Mohideen; Chiu Tang; Sebastian Vaesen; Paul S Wheatley; David W Aldous; Russell E Morris
Metal-organic frameworks for the storage and delivery of biologically active hydrogen sulfide.
Dalton transactions (Cambridge, England : 2003) 2012;41(14):4060-6.
2012: Wan-Seob Cho; Mark Bradley; Rodger Duffin; William MacNee; Ian L Megson; Craig A Poland; Frank Thielbeer; C Lang Tran; Ken Donaldson
Zeta potential and solubility to toxic ions as mechanisms of lung inflammation caused by metal/metal oxide nanoparticles.
Toxicological sciences : an official journal of the Society of Toxicology 2012;126(2):469-77.
2012: Wan-Seob Cho; Mark Bradley; Rodger Duffin; Albert Duschl; William MacNee; Ian L Megson; Gertie J Oostingh; Craig A Poland; Ken Donaldson
Differential pro-inflammatory effects of metal oxide nanoparticles and their soluble ions in vitro and in vivo; zinc and copper nanoparticles, but not their ions, recruit eosinophils to the lungs.
Nanotoxicology 2012;6(1):22-35.
2012: Euan A Sandilands; Adrian Thompson; Neal Uren; David J Webb; Nicholas Bateman; Lesley Briody; Sharon Cameron; Jane Crowe; Sam Donaldson; Julie Donnelly; Jane Goddard; Neil R Johnston; Ivor Mackenzie; Ian L Megson; Frances Paterson; Michael Eddleston
Mechanisms for an effect of acetylcysteine on renal function after exposure to radio-graphic contrast material: study protocol.
BMC clinical pharmacology 2012;12():3.
2011: Susan C McGeoch; Ian L Megson; Donald W M Pearson; Gerald E Lobley; Sandra M Macrury; Prakash Abraham; Claire Fyfe; Grietje Holtrop; Alexandra M Johnstone
Food intake and dietary glycaemic index in free-living adults with and without type 2 diabetes mellitus.
Nutrients 2011;3(6):683-93.
2011: Alexis D Ostrowski; Ryan O Absalonson; Guang Wu; James G Pavlovich; Janet Adamson; Bilal Azhar; Alexei V Iretskii; Ian L Megson; Malcolm A De Leo; Peter C Ford
Photochemistry of trans-Cr(cyclam)(ONO)2+, a nitric oxide precursor.
Inorganic chemistry 2011;50(10):4453-62.
2011: Benjamin H Maskrey; Ian L Megson; Phillip D Whitfield; Adriano G Rossi
Mechanisms of resolution of inflammation: a focus on cardiovascular disease.
Arteriosclerosis, thrombosis, and vascular biology 2011;31(5):1001-6.
2011: Matilda Bradford; Matthew H Law; Ian L Megson; Jun Wei
The functional significance of the TGM2 gene in schizophrenia: a correlation of SNPs and circulating IL-2 levels.
Journal of neuroimmunology 2011;232(1-2):5-7.
2011: Catherine McGuinnes; Rodger Duffin; Simon Brown; Nicholas L Mills; Ian L Megson; William MacNee; Shonna Johnston; Sen Lin Lu; Lang Tran; Rufia Li; Xue Wang; David E Newby; Ken Donaldson
Surface derivatization state of polystyrene latex nanoparticles determines both their potency and their mechanism of causing human platelet aggregation in vitro.
Toxicological sciences : an official journal of the Society of Toxicology 2011;119(2):359-68.
2011: Wan-Seob Cho; Mark Bradley; Rodger Duffin; Sarah E M Howie; William MacNee; Ian L Megson; Chris J Scotton; William A H Wallace; Ken Donaldson
Progressive severe lung injury by zinc oxide nanoparticles; the role of Zn2+ dissolution inside lysosomes.
Particle and fibre toxicology 2011;8():27.
2011: Kyle R Gibson; Sandra M MacRury; Sushma Sharma; Tim J Winterburn; Fiona Barrett; Ian L Megson
Therapeutic potential of N-acetylcysteine as an antiplatelet agent in patients with type-2 diabetes.
Cardiovascular diabetology 2011;10():43.
2011: Catherine A Shaw; Emma L Taylor; Sarah Fox; Ian L Megson; Adriano G Rossi
Differential susceptibility to nitric oxide-evoked apoptosis in human inflammatory cells.
Free radical biology & medicine 2011;50(1):93-101.
2010: Wan-Seob Cho; Rodger Duffin; Craig A Poland; Sarah E M Howie; William MacNee; Mark Bradley; Ian L Megson; Ken Donaldson
Metal oxide nanoparticles induce unique inflammatory footprints in the lung: important implications for nanoparticle testing.
Environmental health perspectives 2010;118(12):1699-706.
2010: Oliver P Keown; Timothy J Winterburn; Cherry L Wainwright; Sandra M Macrury; Ilene Neilson; Fiona Barrett; Stephen J Leslie; Ian L Megson
2-arachidonyl glycerol activates platelets via conversion to arachidonic acid and not by direct activation of cannabinoid receptors.
British journal of clinical pharmacology 2010;70(2):180-8.
2010: Aditi Mathur; Matthew H Law; Ian L Megson; Duncan J Shaw; Jun Wei
Genetic association of the AKT1 gene with schizophrenia in a British population.
Psychiatric genetics 2010;20(3):118-22.
2010: A G Japp; Nicholas L M Cruden; G Barnes; N van Gemeren; J Mathews; J Adamson; Neil R Johnston; Martin A Denvir; Ian L Megson; Andrew D Flapan; David E Newby
Acute cardiovascular effects of apelin in humans: potential role in patients with chronic heart failure.
Circulation 2010;121(16):1818-27.
2010: Sarah Fox; Tom S Wilkinson; Paul S Wheatley; Bo Xiao; Russell E Morris; Alistair Sutherland; A John Simpson; Peter G Barlow; Anthony R Butler; Ian L Megson; Adriano G Rossi
NO-loaded Zn(2+)-exchanged zeolite materials: a potential bifunctional anti-bacterial strategy.
Acta biomaterialia 2010;6(4):1515-21.
2010: Tom Van Agtmael; Matthew A Bailey; Ursula Schlötzer-Schrehardt; Eilidh Craigie; Ian J Jackson; David G Brownstein; Ian L Megson; John J Mullins
Col4a1 mutation in mice causes defects in vascular function and low blood pressure associated with reduced red blood cell volume.
Human molecular genetics 2010;19(6):1119-28.
2010: Alexis D Ostrowski; Sherine J Deakin; Bilal Azhar; Thomas W Miller; Nestor Franco; Melisa M Cherney; Andrea J Lee; Judith N Burstyn; Jon M Fukuto; Ian L Megson; Peter C Ford
Nitric oxide photogeneration from trans-Cr(cyclam)(ONO)(2)(+) in a reducing environment. activation of soluble guanylyl cyclase and arterial vasorelaxation.
Journal of medicinal chemistry 2010;53(2):715-22.
2009: Kyle R Gibson; Ilene L Neilson; Fiona Barrett; Tim J Winterburn; Sushma Sharma; Sandra M MacRury; Ian L Megson
Evaluation of the antioxidant properties of N-acetylcysteine in human platelets: prerequisite for bioconversion to glutathione for antioxidant and antiplatelet activity.
Journal of cardiovascular pharmacology 2009;54(4):319-26.
2009: Aditi Mathur; Matthew H Law; Tayebeh Hamzehloei; Ian L Megson; Duncan J Shaw; Jun Wei
No association between the PPARG gene and schizophrenia in a British population.
Prostaglandins, leukotrienes, and essential fatty acids 2009;81(4):273-7.
2009: Mark R Miller; Stephen J Borthwick; Catherine A Shaw; Steven G McLean; Daniel McClure; Nicholas L Mills; Rodger Duffin; Ken Donaldson; Ian L Megson; Patrick W F Hadoke; David E Newby
Direct impairment of vascular function by diesel exhaust particulate through reduced bioavailability of endothelium-derived nitric oxide induced by superoxide free radicals.
Environmental health perspectives 2009;117(4):611-6.
2009: Sylwia Michlewska; Ian Dransfield; Ian L Megson; Adriano G Rossi
Macrophage phagocytosis of apoptotic neutrophils is critically regulated by the opposing actions of pro-inflammatory and anti-inflammatory agents: key role for TNF-alpha.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2009;23(3):844-54.
2009: Catherine A Shaw; David J Webb; Adriano G Rossi; Ian L Megson
Cyclic GMP protects human macrophages against peroxynitrite-induced apoptosis.
Journal of inflammation (London, England) 2009;6():14.
2008: Alan G Japp; Nicholas L M Cruden; David A B Amer; Vivienne K Y Li; Ewan B Goudie; Neil R Johnston; Sushma Sharma; Ilene Neilson; David J Webb; Ian L Megson; Andrew D Flapan; David E Newby
Vascular effects of apelin in vivo in man.
Journal of the American College of Cardiology 2008;52(11):908-13.
2008: Nasrin Pakravan; W Stephen Waring; Sushma Sharma; Christopher Ludlam; Ian L Megson; D Nicholas Bateman
Risk factors and mechanisms of anaphylactoid reactions to acetylcysteine in acetaminophen overdose.
Clinical toxicology (Philadelphia, Pa.) 2008;46(8):697-702.
2008: Michelle Le Brocq; Stephen J Leslie; Philip Milliken; Ian L Megson
Endothelial dysfunction: from molecular mechanisms to measurement, clinical implications, and therapeutic opportunities.
Antioxidants & redox signaling 2008;10(9):1631-74.
2008: koremu meja; Saravanan Rajendrasozhan; David Adenuga; Saibal K Biswas; Isaac Kirubakaran Sundar; Gillian Spooner; John A Marwick; Probir Chakravarty; Danielle Fletcher; Paul Whittaker; Ian L Megson; Paul A Kirkham; Irfan Rahman
Curcumin restores corticosteroid function in monocytes exposed to oxidants by maintaining HDAC2.
American journal of respiratory cell and molecular biology 2008;39(3):312-23.
2008: Alistair C McKinlay; Bo Xiao; David S Wragg; Paul S Wheatley; Ian L Megson; Russell E Morris
Exceptional behavior over the whole adsorption-storage-delivery cycle for NO in porous metal organic frameworks.
Journal of the American Chemical Society 2008;130(31):10440-4.
2008: Aruna Kode; Saravanan Rajendrasozhan; Samuel Caito; Se-Ran Yang; Ian L Megson; Irfan Rahman
Resveratrol induces glutathione synthesis by activation of Nrf2 and protects against cigarette smoke-mediated oxidative stress in human lung epithelial cells.
American journal of physiology. Lung cellular and molecular physiology 2008;294(3):L478-88.
2008: Danhua Du; Peng Gao; Linsen Hu; Yumei Yang; Feng Wang; Lin Ye; Xuan Zhang; Ming Chang; Jiexu Zhao; Jiang Wu; Ian L Megson; Jun Wei
A genetic study of the NOS3 gene for ischemic stroke in a Chinese population.
International journal of general medicine 2008;1():65-8.
2008: Catriona M Turnbull; Paolo Marcarino; Tara A Sheldrake; Loretta Lazzarato; Clara Cena; Roberta Fruttero; Alberto Gasco; Sarah Fox; Ian L Megson; Adriano G Rossi
A novel hybrid aspirin-NO-releasing compound inhibits TNFalpha release from LPS-activated human monocytes and macrophages.
Journal of inflammation (London, England) 2008;5():12.
2007: Håkan Törnqvist; Nicholas L Mills; Manuel Gonzalez; Mark R Miller; Simon D Robinson; Ian L Megson; William MacNee; Ken Donaldson; Stefan Söderberg; David E Newby; Thomas Sandström; Anders Blomberg
Persistent endothelial dysfunction in humans after diesel exhaust inhalation.
American journal of respiratory and critical care medicine 2007;176(4):395-400.
2007: Sylwia Michlewska; Aisleen McColl; Adriano G Rossi; Ian L Megson; Ian Dransfield
Clearance of dying cells and autoimmunity.
Autoimmunity 2007;40(4):267-73.
2007: M R Miller; Ian L Megson
Recent developments in nitric oxide donor drugs.
British journal of pharmacology 2007;151(3):305-21.
2007: Bo Xiao; Paul S Wheatley; Xuebo Zhao; Ashleigh J Fletcher; Sarah Fox; Adriano G Rossi; Ian L Megson; Silvia Bordiga; Laura Regli; K Mark Thomas; Russell E Morris
High-capacity hydrogen and nitric oxide adsorption and storage in a metal-organic framework.
Journal of the American Chemical Society 2007;129(5):1203-9.
2006: Catriona M Turnbull; Adriano G Rossi; Ian L Megson
Therapeutic effects of nitric oxide-aspirin hybrid drugs.
Expert opinion on therapeutic targets 2006;10(6):911-22.
2006: Ingibjörg J Gudmundsdóttir; Ian L Megson; Jillian S Kell; Christopher A Ludlam; Keith A A Fox; David J Webb; David E Newby
Direct vascular effects of protease-activated receptor type 1 agonism in vivo in humans.
Circulation 2006;114(15):1625-32.
2006: Anna R Dover; Stanley Chia; James W Ferguson; Nicholas L M Cruden; Ian L Megson; Keith A A Fox; David E Newby
Inducible nitric oxide synthase activity does not contribute to the maintenance of peripheral vascular tone in patients with heart failure.
Clinical science (London, England : 1979) 2006;111(4):275-80.
2006: Katharine H Fraser; Tamie L Poepping; Alan S McNeilly; Ian L Megson; Peter R Hoskins
Acoustic speed and attenuation coefficient in sheep aorta measured at 5-9 MHz.
Ultrasound in medicine & biology 2006;32(6):971-80.
2006: Catriona M Turnbull; Clara Cena; Roberta Fruttero; Alberto Gasco; Adriano G Rossi; Ian L Megson
Mechanism of action of novel NO-releasing furoxan derivatives of aspirin in human platelets.
British journal of pharmacology 2006;148(4):517-26.
2006: Paul S Wheatley; Anthony R Butler; Michael S Crane; Sarah Fox; Bo Xiao; Adriano G Rossi; Ian L Megson; Russell E Morris
NO-releasing zeolites and their antithrombotic properties.
Journal of the American Chemical Society 2006;128(2):502-9.
2006: Catriona M Turnbull; Danny McClure; Adriano G Rossi; Ian L Megson
A novel electron paramagnetic resonance-based assay for prostaglandin H synthase-1 activity.
Journal of inflammation (London, England) 2006;3():12.
2005: Saibal K Biswas; David E Newby; Irfan Rahman; Ian L Megson
Depressed glutathione synthesis precedes oxidative stress and atherogenesis in Apo-E(-/-) mice.
Biochemical and biophysical research communications 2005;338(3):1368-73.
2005: Ingibjörg J Gudmundsdóttir; Sarah J McRobbie; Simon D Robinson; David E Newby; Ian L Megson
Sildenafil potentiates nitric oxide mediated inhibition of human platelet aggregation.
Biochemical and biophysical research communications 2005;337(1):382-5.
2005: Deborah A Sawatzky; Ian L Megson; Adriano G Rossi
Sildenafil offers protection against NSAID-induced gastric injury.
British journal of pharmacology 2005;146(4):477-8.
2005: Nicholas L M Cruden; George H Tse; Keith A A Fox; Christopher A Ludlam; Ian L Megson; David E Newby
B1 kinin receptor does not contribute to vascular tone or tissue plasminogen activator release in the peripheral circulation of patients with heart failure.
Arteriosclerosis, thrombosis, and vascular biology 2005;25(4):772-7.
2005: Catherine A Shaw; Emma L Taylor; Ian L Megson; Adriano G Rossi
Nitric oxide and the resolution of inflammation: implications for atherosclerosis.
Memórias do Instituto Oswaldo Cruz 2005;100 Suppl 1():67-71.
2005: Michael S Crane; Adriano G Rossi; Ian L Megson
A potential role for extracellular nitric oxide generation in cGMP-independent inhibition of human platelet aggregation: biochemical and pharmacological considerations.
British journal of pharmacology 2005;144(6):849-59.
2005: Saibal K Biswas; Danny McClure; Luis A Jimenez; Ian L Megson; Irfan Rahman
Curcumin induces glutathione biosynthesis and inhibits NF-kappaB activation and interleukin-8 release in alveolar epithelial cells: mechanism of free radical scavenging activity.
Antioxidants & redox signaling 2005;7(1-2):32-41.
2004: Emma L Taylor; Adriano G Rossi; Catherine A Shaw; Francesco P Dal Rio; Christopher Haslett; Ian L Megson
GEA 3162 decomposes to co-generate nitric oxide and superoxide and induces apoptosis in human neutrophils via a peroxynitrite-dependent mechanism.
British journal of pharmacology 2004;143(1):179-85.
2004: Mark R Miller; K Okubo; MJ Roseberry; David J Webb; Ian L Megson
Extracellular nitric oxide release mediates soluble guanylate cyclase-independent vasodilator action of spermine NONOate: comparison with other nitric oxide donors in isolated rat femoral arteries.
Journal of cardiovascular pharmacology 2004;43(3):440-51.
2003: Frederick ('Eric') Werner Flitney; Ian L Megson
Nitric oxide and the mechanism of rat vascular smooth muscle photorelaxation.
The Journal of physiology 2003;550(Pt 3):819-28.
2003: Emma L Taylor; Ian L Megson; Christopher Haslett; Adriano G Rossi
Nitric oxide: a key regulator of myeloid inflammatory cell apoptosis.
Cell death and differentiation 2003;10(4):418-30.
2003: Mark R Miller; Inderraj S Hanspal; Patrick W F Hadoke; David E Newby; Adriano G Rossi; David J Webb; Ian L Megson
A novel S-nitrosothiol causes prolonged and selective inhibition of platelet adhesion at sites of vascular injury.
Cardiovascular research 2003;57(3):853-60.
2003: Clara Cena; Marco L Lolli; Loretta Lazzarato; Elena Guaita; Giovanni Morini; Gabriella Coruzzi; Stuart P McElroy; Ian L Megson; Roberta Fruttero; Alberto Gasco
Antiinflammatory, gastrosparing, and antiplatelet properties of new NO-donor esters of aspirin.
Journal of medicinal chemistry 2003;46(5):747-54.
2003: Stanley Chia; Ian L Megson; Christopher A Ludlam; Keith A A Fox; David E Newby
Preserved endothelial vasomotion and fibrinolytic function in patients with acute stent thrombosis or in-stent restenosis.
Thrombosis research 2003;111(6):343-9.
2002: Michael S Crane; Richard Ollosson; Kevin P Moore; Adriano G Rossi; Ian L Megson
Novel role for low molecular weight plasma thiols in nitric oxide-mediated control of platelet function.
The Journal of biological chemistry 2002;277(49):46858-63.
2002: Inderraj S Hanspal; Kesson S Magid; David J Webb; Ian L Megson
The effect of oxidative stress on endothelium-dependent and nitric oxide donor-induced relaxation: implications for nitrate tolerance.
Nitric oxide : biology and chemistry / official journal of the Nitric Oxide Society 2002;6(3):263-70.
2002: Ian L Megson; David J Webb
Nitric oxide donor drugs: current status and future trends.
Expert opinion on investigational drugs 2002;11(5):587-601.
2002: Anthony R Butler; Ian L Megson
Non-heme iron nitrosyls in biology.
Chemical reviews 2002;102(4):1155-66.
2001: Emma L Taylor; Ian L Megson; Christopher Haslett; Adriano G Rossi
Dissociation of DNA fragmentation from other hallmarks of apoptosis in nitric oxide-treated neutrophils: differences between individual nitric oxide donor drugs.
Biochemical and biophysical research communications 2001;289(5):1229-36.
2001: C Labinjoh; David E Newby; Ian B Wilkinson; Ian L Megson; Helen MacCallum; V Melville; Nicholas A Boon; David J Webb
Effects of acute methionine loading and vitamin C on endogenous fibrinolysis, endothelium-dependent vasomotion and platelet aggregation.
Clinical science (London, England : 1979) 2001;100(2):127-35.
2000: N Sogo; Kesson S Magid; Catherine A Shaw; David J Webb; Ian L Megson
Inhibition of human platelet aggregation by nitric oxide donor drugs: relative contribution of cGMP-independent mechanisms.
Biochemical and biophysical research communications 2000;279(2):412-9.
2000: Ian L Megson; N Sogo; FA Mazzei; Anthony R Butler; J C Walton; David J Webb
Inhibition of human platelet aggregation by a novel S-nitrosothiol is abolished by haemoglobin and red blood cells in vitro: implications for anti-thrombotic therapy.
British journal of pharmacology 2000;131(7):1391-8.
2000: Mark R Miller; MJ Roseberry; FA Mazzei; Anthony R Butler; David J Webb; Ian L Megson
Novel S-nitrosothiols do not engender vascular tolerance and remain effective in glyceryltrinitrate-tolerant rat femoral arteries.
European journal of pharmacology 2000;408(3):335-43.
2000: N Sogo; C Campanella; David J Webb; Ian L Megson
S-nitrosothiols cause prolonged, nitric oxide-mediated relaxation in human saphenous vein and internal mammary artery: therapeutic potential in bypass surgery.
British journal of pharmacology 2000;131(6):1236-44.
2000: Mark R Miller; Ian L Megson; MJ Roseberry; FA Mazzei; Anthony R Butler; David J Webb
Novel S-nitrosothiols do not engender vascular tolerance and remain effective in glyceryl trinitrate-tolerant rat femoral arteries.
European journal of pharmacology 2000;403(1-2):111-9.
2000: A A Miller; Ian L Megson; Gillian A Gray
Inducible nitric oxide synthase-derived superoxide contributes to hypereactivity in small mesenteric arteries from a rat model of chronic heart failure.
British journal of pharmacology 2000;131(1):29-36.
2000: Ian L Megson; S A Holmes; Kesson S Magid; R J Pritchard; Frederick ('Eric') Werner Flitney
Selective modifiers of glutathione biosynthesis and 'repriming' of vascular smooth muscle photorelaxation.
British journal of pharmacology 2000;130(7):1575-80.
2000: N Sogo; Ian B Wilkinson; Helen MacCallum; S Q Khan; Fiona E Strachan; David E Newby; Ian L Megson; David J Webb
A novel S-nitrosothiol (RIG200) causes prolonged relaxation in dorsal hand veins with damaged endothelium.
Clinical pharmacology and therapeutics 2000;68(1):75-81.
1999: I B Wilkinson; Ian L Megson; Helen MacCallum; N Sogo; J R Cockcroft; David J Webb
Oral vitamin C reduces arterial stiffness and platelet aggregation in humans.
Journal of cardiovascular pharmacology 1999;34(5):690-3.
1999: Ian L Megson; S Morton; IR Greig; FA Mazzei; R A Field; Anthony R Butler; Giulia Caron; Alberto Gasco; Roberta Fruttero; David J Webb
N-Substituted analogues of S-nitroso-N-acetyl-D,L-penicillamine: chemical stability and prolonged nitric oxide mediated vasodilatation in isolated rat femoral arteries.
British journal of pharmacology 1999;126(3):639-48.
1998: Anthony R Butler; Ian L Megson; P G Wright
Diffusion of nitric oxide and scavenging by blood in the vasculature.
Biochimica et biophysica acta 1998;1425(1):168-76.
1998: Anthony R Butler; H H Al-Sa'doni; Ian L Megson; Frederick ('Eric') Werner Flitney
Synthesis, decomposition, and vasodilator action of some new S-nitrosated dipeptides.
Nitric oxide : biology and chemistry / official journal of the Nitric Oxide Society 1998;2(3):193-202.
1997: Ian L Megson; IR Greig; Gillian A Gray; David J Webb; Anthony R Butler
Prolonged effect of a novel S-nitrosated glyco-amino acid in endothelium-denuded rat femoral arteries: potential as a slow release nitric oxide donor drug.
British journal of pharmacology 1997;122(8):1617-24.
1997: Simon P Fricker; E Slade; NA Powell; O J Vaughan; G R Henderson; B A Murrer; Ian L Megson; SK Bisland; Frederick ('Eric') Werner Flitney
Ruthenium complexes as nitric oxide scavengers: a potential therapeutic approach to nitric oxide-mediated diseases.
British journal of pharmacology 1997;122(7):1441-9.
1997: H H Al-Sa'doni; Ian L Megson; SK Bisland; Anthony R Butler; Frederick ('Eric') Werner Flitney
Neocuproine, a selective Cu(I) chelator, and the relaxation of rat vascular smooth muscle by S-nitrosothiols.
British journal of pharmacology 1997;121(6):1047-50.
1997: Ian L Megson; IR Greig; Anthony R Butler; Gillian A Gray; David J Webb
Therapeutic potential of S-nitrosothiols as nitric oxide donor drugs.
Scottish medical journal 1997;42(3):88-9.
1996: Frederick ('Eric') Werner Flitney; Ian L Megson; J L Thomson; G D Kennovin; Anthony R Butler
Vasodilator responses of rat isolated tail artery enhanced by oxygen- dependent, photochemical release of nitric oxide from iron-sulphur-nitrosyls.
British journal of pharmacology 1996;117(7):1549-57.
1995: S C Askew; Anthony R Butler; Frederick ('Eric') Werner Flitney; Graham D Kemp; Ian L Megson
Chemical mechanisms underlying the vasodilator and platelet anti-aggregating properties of S-nitroso-N-acetyl-DL-penicillamine and S-nitrosoglutathione.
Bioorganic & medicinal chemistry 1995;3(1):1-9.
1992: Frederick ('Eric') Werner Flitney; Ian L Megson; D E Flitney; Anthony R Butler
Iron-sulphur cluster nitrosyls, a novel class of nitric oxide generator: mechanism of vasodilator action on rat isolated tail artery.
British journal of pharmacology 1992;107(3):842-8.