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Harihara Mehendale

Research Profile

Living Beings

Anatomy

Livers

Chemicals & Drugs

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Drug-Induced Liver Injury

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TOP 3
Harihara M Mehendale
Once initiated, how does toxic tissue injury expand?
Vishakha S Bhave; Shashikiran Donthamsetty; John R Latendresse; Michael L Cunningham; Harihara M Mehendale
Secretory phospholipase A₂-mediated progression of hepatotoxicity initiated by acetaminophen is exacerbated in the absence of hepatic COX-2.
Mayurranjan S Mitra; Shashikiran Donthamsetty; Brent White; Harihara M Mehendale
High fat diet-fed obese rats are highly sensitive to doxorubicin-induced cardiotoxicity.

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All Publications

2012: Harihara M Mehendale
Once initiated, how does toxic tissue injury expand?
Trends in pharmacological sciences 2012;33(4):200-6.
2011: Vishakha S Bhave; Shashikiran Donthamsetty; John R Latendresse; Michael L Cunningham; Harihara M Mehendale
Secretory phospholipase A₂-mediated progression of hepatotoxicity initiated by acetaminophen is exacerbated in the absence of hepatic COX-2.
Toxicology and applied pharmacology 2011;251(3):173-80.
2008: Mayurranjan S Mitra; Shashikiran Donthamsetty; Brent White; Harihara M Mehendale
High fat diet-fed obese rats are highly sensitive to doxorubicin-induced cardiotoxicity.
Toxicology and applied pharmacology 2008;231(3):413-22.
2008: Shashikiran Donthamsetty; Vishakha S Bhave; Mayurranjan S Mitra; John R Latendresse; Harihara M Mehendale
Nonalcoholic steatohepatitic (NASH) mice are protected from higher hepatotoxicity of acetaminophen upon induction of PPARalpha with clofibrate.
Toxicology and applied pharmacology 2008;230(3):327-37.
2008: Prajakta S Palkar; David G Kakhniashvili; Steven R Goodman; Harihara M Mehendale
The rat red blood cell proteome is altered by priming with 2-butoxyethanol.
Toxicology and applied pharmacology 2008;230(3):338-45.
2008: Vishakha S Bhave; Shashikiran Donthamsetty; John R Latendresse; Harihara M Mehendale
Inhibition of cyclooxygenase-2 aggravates secretory phospholipase A2-mediated progression of acute liver injury.
Toxicology and applied pharmacology 2008;228(2):239-46.
2008: Vishakha S Bhave; Shashikiran Donthamsetty; John R Latendresse; Levan Muskhelishvili; Harihara M Mehendale
Secretory phospholipase A2 mediates progression of acute liver injury in the absence of sufficient cyclooxygenase-2.
Toxicology and applied pharmacology 2008;228(2):225-38.
2008: Michael T Nowicki; Lauren M Aleksunes; Sharmilee P Sawant; Ankur Dnyanmote; Harihara M Mehendale; José E Manautou
Renal and hepatic transporter expression in type 2 diabetic rats.
Drug metabolism letters 2008;2(1):11-7.
2007: Mayurranjan S Mitra; Shashikiran Donthamsetty; Brent White; John R Latendresse; Harihara M Mehendale
Mechanism of protection of moderately diet restricted rats against doxorubicin-induced acute cardiotoxicity.
Toxicology and applied pharmacology 2007;225(1):90-101.
2007: Prajakta S Palkar; binu Philip; Ramesh N Reddy; Harihara M Mehendale
Priming dose of phenylhydrazine protects against hemolytic and lethal effects of 2-butoxyethanol.
Toxicology and applied pharmacology 2007;225(1):102-12.
2007: Midhun C Korrapati; Jaya Chilakapati; Frank A Witzmann; Chundury Rao; Edward A Lock; Harihara M Mehendale
Proteomics of S-(1, 2-dichlorovinyl)-L-cysteine-induced acute renal failure and autoprotection in mice.
American journal of physiology. Renal physiology 2007;293(4):F994-F1006.
2007: Erica L Liebelt; Sophie Balk; Willem Faber; Jeffrey W Fisher; Claude L Hughes; Sophie Lanzkron; Kerry M Lewis; Francesco Marchetti; Harihara M Mehendale; John M Rogers; Aziza T Shad; Richard G Skalko; Edward J Stanek
NTP-CERHR expert panel report on the reproductive and developmental toxicity of hydroxyurea.
Birth defects research. Part B, Developmental and reproductive toxicology 2007;80(4):259-366.
2007: Tao Wang; Kartik Shankar; Martin J J Ronis; Harihara M Mehendale
Mechanisms and outcomes of drug- and toxicant-induced liver toxicity in diabetes.
Critical reviews in toxicology 2007;37(5):413-59.
2007: Sachin S Devi; Prajakta S Palkar; Harihara M Mehendale
Measuring covalent binding in hepatotoxicity.
Current protocols in toxicology / editorial board, Mahin D. Maines (editor-in-chief) ... [et al.] 2007;Chapter 14():Unit14.6.
2007: Sharmilee P Sawant; Ankur Dnyanmote; Harihara M Mehendale
Mechanisms of inhibited liver tissue repair in toxicant challenged type 2 diabetic rats.
Toxicology 2007;232(3):200-15.
2007: binu Philip; Moiz M Mumtaz; John R Latendresse; Harihara M Mehendale
Impact of repeated exposure on toxicity of perchloroethylene in Swiss Webster mice.
Toxicology 2007;232(1-2):1-14.
2007: Jaya Chilakapati; Midhun C Korrapati; Kartik Shankar; Ronald A Hill; Alan Warbritton; John R Latendresse; Harihara M Mehendale
Role of CYP2E1 and saturation kinetics in the bioactivation of thioacetamide: Effects of diet restriction and phenobarbital.
Toxicology and applied pharmacology 2007;219(1):72-84.
2007: Jaya Chilakapati; Midhun C Korrapati; Ronald A Hill; Alan Warbritton; John R Latendresse; Harihara M Mehendale
Toxicokinetics and toxicity of thioacetamide sulfoxide: a metabolite of thioacetamide.
Toxicology 2007;230(2-3):105-16.
2007: Shashikiran Donthamsetty; Vishakha S Bhave; Mayurranjan S Mitra; John R Latendresse; Harihara M Mehendale
Nonalcoholic fatty liver sensitizes rats to carbon tetrachloride hepatotoxicity.
Hepatology (Baltimore, Md.) 2007;45(2):391-403.
2006: binu Philip; Sathanandam S Anand; Prajakta S Palkar; Moiz M Mumtaz; John R Latendresse; Harihara M Mehendale
Subchronic chloroform priming protects mice from a subsequently administered lethal dose of chloroform.
Toxicology and applied pharmacology 2006;216(1):108-21.
2006: Sachin S Devi; binu Philip; Alan Warbritton; John R Latendresse; Harihara M Mehendale
Prior administration of a low dose of thioacetamide protects type 1 diabetic rats from subsequent administration of lethal dose of thioacetamide.
Toxicology 2006;226(2-3):107-17.
2006: Ankur Dnyanmote; Sharmilee P Sawant; Edward A Lock; John R Latendresse; Alan A Warbritton; Harihara M Mehendale
Calpastatin overexpression prevents progression of S-1,2-dichlorovinyl-l-cysteine (DCVC)-initiated acute renal injury and renal failure (ARF) in diabetes.
Toxicology and applied pharmacology 2006;215(2):146-57.
2006: Pallavi B Limaye; Vishakha S Bhave; Prajakta S Palkar; Udayan M Apte; Sharmilee P Sawant; Songtao Yu; John R Latendresse; Janardan K Reddy; Harihara M Mehendale
Upregulation of calpastatin in regenerating and developing rat liver: role in resistance against hepatotoxicity.
Hepatology (Baltimore, Md.) 2006;44(2):379-88.
2006: Midhun C Korrapati; Jaya Chilakapati; Edward A Lock; John R Latendresse; Alan Warbritton; Harihara M Mehendale
Preplaced cell division: a critical mechanism of autoprotection against S-1,2-dichlorovinyl-L-cysteine-induced acute renal failure and death in mice.
American journal of physiology. Renal physiology 2006;291(2):F439-55.
2006: Sathanandam S Anand; binu Philip; Prajakta S Palkar; Moiz M Mumtaz; John R Latendresse; Harihara M Mehendale
Adaptive tolerance in mice upon subchronic exposure to chloroform: Increased exhalation and target tissue regeneration.
Toxicology and applied pharmacology 2006;213(3):267-81.
2006: Ling He; Frank A Simmen; Harihara M Mehendale; Martin J J Ronis; Thomas M Badger
Chronic ethanol intake impairs insulin signaling in rats by disrupting Akt association with the cell membrane. Role of TRB3 in inhibition of Akt/protein kinase B activation.
The Journal of biological chemistry 2006;281(16):11126-34.
2006: Sachin S Devi; Harihara M Mehendale
Microarray analysis of thioacetamide-treated type 1 diabetic rats.
Toxicology and applied pharmacology 2006;212(1):69-78.
2006: Ramesh N Reddy; John R Latendresse; Harihara M Mehendale
Colchicine antimitosis causes progression of S-(1,2-dichlorovinyl)-L-cysteine-induced injury leading to acute renal failure and death in mice.
Toxicology 2006;220(2-3):147-59.
2006: Sharmilee P Sawant; Ankur Dnyanmote; Alan Warbritton; John R Latendresse; Harihara M Mehendale
Type 2 diabetic rats are sensitive to thioacetamide hepatotoxicity.
Toxicology and applied pharmacology 2006;211(3):221-32.
2006: Ankur Dnyanmote; Sharmilee P Sawant; Edward A Lock; John R Latendresse; Alan A Warbritton; Harihara M Mehendale
Diabetic mice are protected from normally lethal nephrotoxicity of S-1,2-dichlorovinyl-L-cysteine (DCVC): role of nephrogenic tissue repair.
Toxicology and applied pharmacology 2006;211(2):133-47.
2006: Sharmilee P Sawant; Ankur Dnyanmote; Mayurranjan S Mitra; Jaya Chilakapati; Alan Warbritton; John R Latendresse; Harihara M Mehendale
Protective effect of type 2 diabetes on acetaminophen-induced hepatotoxicity in male Swiss-Webster mice.
The Journal of pharmacology and experimental therapeutics 2006;316(2):507-19.
2005: Jaya Chilakapati; Kartik Shankar; Midhun C Korrapati; Ronald A Hill; Harihara M Mehendale
Saturation toxicokinetics of thioacetamide: role in initiation of liver injury.
Drug metabolism and disposition: the biological fate of chemicals 2005;33(12):1877-85.
2005: Sathanandam S Anand; Moiz M Mumtaz; Harihara M Mehendale
Dose-dependent liver regeneration in chloroform, trichloroethylene and allyl alcohol ternary mixture hepatotoxicity in rats.
Archives of toxicology 2005;79(11):671-82.
2005: Sachin S Devi; Harihara M Mehendale
The role of NF-kappaB signaling in impaired liver tissue repair in thioacetamide-treated type 1 diabetic rats.
European journal of pharmacology 2005;523(1-3):127-36.
2005: Sachin S Devi; Harihara M Mehendale
Disrupted G1 to S phase clearance via cyclin signaling impairs liver tissue repair in thioacetamide-treated type 1 diabetic rats.
Toxicology and applied pharmacology 2005;207(2):89-102.
2005: Midhun C Korrapati; Edward A Lock; Harihara M Mehendale
Molecular mechanisms of enhanced renal cell division in protection against S-1,2-dichlorovinyl-L-cysteine-induced acute renal failure and death.
American journal of physiology. Renal physiology 2005;289(1):F175-85.
2005: Sathanandam S Anand; Moiz M Mumtaz; Harihara M Mehendale
Dose-dependent liver tissue repair after chloroform plus trichloroethylene binary mixture.
Basic & clinical pharmacology & toxicology 2005;96(6):436-44.
2005: Harihara M Mehendale; Pallavi B Limaye
Calpain: a death protein that mediates progression of liver injury.
Trends in pharmacological sciences 2005;26(5):232-6.
2005: Harihara M Mehendale
Tissue repair: an important determinant of final outcome of toxicant-induced injury.
Toxicologic pathology 2005;33(1):41-51.
2004: Sathanandam S Anand; Harihara M Mehendale
Liver regeneration: a critical toxicodynamic response in predictive toxicology.
Environmental toxicology and pharmacology 2004;18(2):149-60.
2004: Sathanandam S Anand; Moiz M Mumtaz; Subramanyam N Murthy; Harihara M Mehendale
Dose-dependent liver tissue repair in chloroform plus thioacetamide acute hepatotoxicity.
Environmental toxicology and pharmacology 2004;18(2):143-8.
2004: J Christopher Corton; Udayan M Apte; Anderson Steven; Pallavi B Limaye; Lawrence Yoon; John R Latendresse; Corrie Dunn; Jeffrey I Everitt; Kenneth A Voss; Cynthia Swanson; Carie Kimbrough; Jean S Wong; Sarjeet S Gill; Roshantha A S Chandraratna; Mi-Kyoung Kwak; Thomas W Kensler; Thomas M Stulnig; Knut R Steffensen; Jan-�ke GUSTAFSSON; Harihara M Mehendale
Mimetics of caloric restriction include agonists of lipid-activated nuclear receptors.
The Journal of biological chemistry 2004;279(44):46204-12.
2004: B Murali; Midhun C Korrapati; Alan Warbritton; John R Latendresse; Harihara M Mehendale
Tolerance of aged Fischer 344 rats against chlordecone-amplified carbon tetrachloride toxicity.
Mechanisms of ageing and development 2004;125(6):421-35.
2004: Harihara M Mehendale
Genetically modified foods get bad rap.
International journal of toxicology 2004;23(2):79-80.
2004: Sharmilee P Sawant; Ankur Dnyanmote; Kartik Shankar; Pallavi B Limaye; John R Latendresse; Harihara M Mehendale
Potentiation of carbon tetrachloride hepatotoxicity and lethality in type 2 diabetic rats.
The Journal of pharmacology and experimental therapeutics 2004;308(2):694-704.
2004: Harihara M Mehendale
Genetically modified foods: why the public frenzy? Role of mainstream news media.
International journal of toxicology 2004;23(5):279-80.
2003: Vishal S Vaidya; Kartik Shankar; Edward A Lock; Darlene Dixon; Harihara M Mehendale
Molecular mechanisms of renal tissue repair in survival from acute renal tubule necrosis: role of ERK1/2 pathway.
Toxicologic pathology 2003;31(6):604-18.
2003: Pallavi B Limaye; Udayan M Apte; Kartik Shankar; Thomas J Bucci; Alan Warbritton; Harihara M Mehendale
Calpain released from dying hepatocytes mediates progression of acute liver injury induced by model hepatotoxicants.
Toxicology and applied pharmacology 2003;191(3):211-26.
2003: Kartik Shankar; Vishal S Vaidya; J Christopher Corton; Thomas J Bucci; Jie Liu; Michael P Waalkes; Harihara M Mehendale
Activation of PPAR-alpha in streptozotocin-induced diabetes is essential for resistance against acetaminophen toxicity.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2003;17(12):1748-50.
2003: Sathanandam S Anand; Subramanyam N Murthy; Vishal S Vaidya; Moiz M Mumtaz; Harihara M Mehendale
Tissue repair plays pivotal role in final outcome of liver injury following chloroform and allyl alcohol binary mixture.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2003;41(8):1123-32.
2003: Vishal S Vaidya; Kartik Shankar; Edward A Lock; Thomas J Bucci; Harihara M Mehendale
Role of tissue repair in survival from s-(1,2-dichlorovinyl)-L-cysteine-induced acute renal tubular necrosis in the mouse.
Toxicological sciences : an official journal of the Society of Toxicology 2003;74(1):215-27.
2003: Kartik Shankar; Vishal S Vaidya; Udayan M Apte; José E Manautou; Martin J J Ronis; Thomas J Bucci; Harihara M Mehendale
Type 1 diabetic mice are protected from acetaminophen hepatotoxicity.
Toxicological sciences : an official journal of the Society of Toxicology 2003;73(2):220-34.
2003: Kartik Shankar; Vishal S Vaidya; Tao Wang; Thomas J Bucci; Harihara M Mehendale
Streptozotocin-induced diabetic mice are resistant to lethal effects of thioacetamide hepatotoxicity.
Toxicology and applied pharmacology 2003;188(2):122-34.
2003: Vishal S Vaidya; Kartik Shankar; Edward A Lock; Thomas J Bucci; Harihara M Mehendale
Renal injury and repair following S-1, 2 dichlorovinyl-L-cysteine administration to mice.
Toxicology and applied pharmacology 2003;188(2):110-21.
2003: Udayan M Apte; Pallavi B Limaye; D Desaiah; Thomas J Bucci; Alan Warbritton; Harihara M Mehendale
Mechanisms of increased liver tissue repair and survival in diet-restricted rats treated with equitoxic doses of thioacetamide.
Toxicological sciences : an official journal of the Society of Toxicology 2003;72(2):272-82.
2003: Sathanandam S Anand; Madhusudan G Soni; Vishal S Vaidya; Subramanyam N Murthy; Moiz M Mumtaz; Harihara M Mehendale
Extent and timeliness of tissue repair determines the dose-related hepatotoxicity of chloroform.
International journal of toxicology 2003;22(1):25-33.
2002: Udayan M Apte; Pallavi B Limaye; Shashi K Ramaiah; Vishal S Vaidya; Thomas J Bucci; Alan Warbritton; Harihara M Mehendale
Upregulated promitogenic signaling via cytokines and growth factors: potential mechanism of robust liver tissue repair in calorie-restricted rats upon toxic challenge.
Toxicological sciences : an official journal of the Society of Toxicology 2002;69(2):448-59.
2001: Shashi K Ramaiah; Udayan M Apte; Harihara M Mehendale
Cytochrome P4502E1 induction increases thioacetamide liver injury in diet-restricted rats.
Drug metabolism and disposition: the biological fate of chemicals 2001;29(8):1088-95.
2001: Tao Wang; Kartik Shankar; Thomas J Bucci; Alan Warbritton; Harihara M Mehendale
Diallyl sulfide inhibition of CYP2E1 does not rescue diabetic rats from thioacetamide-induced mortality.
Toxicology and applied pharmacology 2001;173(1):27-37.
2000: Harihara M Mehendale
PPAR-alpha: a key to the mechanism of hepatoprotection by clofibrate.
Toxicological sciences : an official journal of the Society of Toxicology 2000;57(2):187-90.
2000: Tao Wang; Kartik Shankar; Martin J J Ronis; Harihara M Mehendale
Potentiation of thioacetamide liver injury in diabetic rats is due to induced CYP2E1.
The Journal of pharmacology and experimental therapeutics 2000;294(2):473-9.
2000: Tao Wang; R D Fontenot; Madhusudan G Soni; Thomas J Bucci; Harihara M Mehendale
Enhanced hepatotoxicity and toxic outcome of thioacetamide in streptozotocin-induced diabetic rats.
Toxicology and applied pharmacology 2000;166(2):92-100.
2000: C C Barton; Thomas J Bucci; LG Lomax; A G Warbritton; Harihara M Mehendale
Stimulated pulmonary cell hyperplasia underlies resistance to alpha-naphthylthiourea.
Toxicology 2000;143(2):167-81.
1999: S G Kulkarni; Angela J Harris; D A Casciano; Harihara M Mehendale
Differential protooncogene expression in Sprague Dawley and Fischer 344 rats during 1,2-dichlorobenzene-induced hepatocellular regeneration.
Toxicology 1999;139(1-2):119-27.
1999: Madhusudan G Soni; Shashi K Ramaiah; Moiz M Mumtaz; H Clewell; Harihara M Mehendale
Toxicant-inflicted injury and stimulated tissue repair are opposing toxicodynamic forces in predictive toxicology.
Regulatory toxicology and pharmacology : RTP 1999;29(2 Pt 1):165-74.
1998: Madhusudan G Soni; Harihara M Mehendale
Role of tissue repair in toxicologic interactions among hepatotoxic organics.
Environmental health perspectives 1998;106 Suppl 6():1307-17.
1998: Shashi K Ramaiah; Thomas J Bucci; Alan Warbritton; Madhusudan G Soni; Harihara M Mehendale
Temporal changes in tissue repair permit survival of diet-restricted rats from an acute lethal dose of thioacetamide.
Toxicological sciences : an official journal of the Society of Toxicology 1998;45(2):233-41.
1998: A Dalu; P S Rao; Harihara M Mehendale
Colchicine antimitosis abolishes resiliency of postnatally developing rats to chlordecone-amplified carbon tetrachloride hepatotoxicity and lethality.
Environmental health perspectives 1998;106(9):597-606.
1998: Shashi K Ramaiah; Madhusudan G Soni; Thomas J Bucci; Harihara M Mehendale
Diet restriction enhances compensatory liver tissue repair and survival following administration of lethal dose of thioacetamide.
Toxicology and applied pharmacology 1998;150(1):12-21.
1998: Madhusudan G Soni; RS Mangipudy; Moiz M Mumtaz; Harihara M Mehendale
Tissue repair response as a function of dose during trichloroethylene hepatotoxicity.
Toxicological sciences : an official journal of the Society of Toxicology 1998;42(2):158-65.
1998: RS Mangipudy; Harihara M Mehendale
Temporal changes in tissue repair upon repeated exposure to thioacetamide.
Toxicology and applied pharmacology 1998;149(2):254-7.
1997: S G Kulkarni; Alan Warbritton; Thomas J Bucci; Harihara M Mehendale
Antimitotic intervention with colchicine alters the outcome of o-DCB-induced hepatotoxicity in Fischer 344 rats.
Toxicology 1997;120(2):79-88.
1997: P S Rao; RS Mangipudy; Harihara M Mehendale
Tissue injury and repair as parallel and opposing responses to CCl4 hepatotoxicity: a novel dose-response.
Toxicology 1997;118(2-3):181-93.
1996: P S Rao; A Dalu; S G Kulkarni; Harihara M Mehendale
Stimulated tissue repair prevents lethality in isopropanol-induced potentiation of carbon tetrachloride hepatotoxicity.
Toxicology and applied pharmacology 1996;140(2):235-44.
1996: A Dalu; Harihara M Mehendale
Efficient tissue repair underlies the resiliency of postnatally developing rats to chlordecone + CCl4 hepatotoxicity.
Toxicology 1996;111(1-3):29-42.
1996: S Chanda; Harihara M Mehendale
Role of nutrition in the survival after hepatotoxic injury.
Toxicology 1996;111(1-3):163-78.
1996: R S Mangipudy; P S Rao; Harihara M Mehendale
Effect of an antimitotic agent colchicine on thioacetamide hepatotoxicity.
Environmental health perspectives 1996;104(7):744-9.
1996: S Chanda; Harihara M Mehendale; S Chandra
Nutritional modulation of the final outcome of hepatotoxic injury by energy substrates: an hypothesis for the mechanism.
Medical hypotheses 1996;46(3):261-8.
1996: S G Kulkarni; H Duong; R Gomila; Harihara M Mehendale
Strain differences in tissue repair response to 1,2-dichlorobenzene.
Archives of toxicology 1996;70(11):714-23.
1995: Harihara M Mehendale
Toxicodynamics of low level toxicant interactions of biological significance: inhibition of tissue repair.
Toxicology 1995;105(2-3):251-66.
1995: Harihara M Mehendale
Injury and repair as opposing forces in risk assessment.
Toxicology letters 1995;82-83():891-9.
1995: B L Blaylock; K K Newsom; Steven D Holladay; B K Shipp; T A Bartow; Harihara M Mehendale
Topical exposure to chlordane reduces the contact hypersensitivity response to oxazolone in BALB/c mice.
Toxicology letters 1995;81(2-3):205-11.
1995: R S Mangipudy; S Chanda; Harihara M Mehendale
Hepatocellular regeneration: key to thioacetamide autoprotection.
Pharmacology & toxicology 1995;77(3):182-8.
1995: C M Harper; M G Soni; Harihara M Mehendale; M A Cuchens
Pristane-induced effects on cytochrome P-4501A, ornithine decarboxylase and putrescine in rats.
Cancer letters 1995;95(1-2):11-21.
1995: A Dalu; Alan Warbritton; Thomas J Bucci; Harihara M Mehendale
Age-related susceptibility to chlordecone-potentiated carbon tetrachloride hepatotoxicity and lethality is due to hepatic quiescence.
Pediatric research 1995;38(2):140-8.
1995: B L Blaylock; M Abdel-Nasser; S M McCarty; J A Knesel; K M Tolson; P W Ferguson; Harihara M Mehendale
Suppression of cellular immune responses in BALB/c mice following oral exposure to permethrin.
Bulletin of environmental contamination and toxicology 1995;54(5):768-74.
1995: R S Mangipudy; S Chanda; Harihara M Mehendale
Tissue repair response as a function of dose in thioacetamide hepatotoxicity.
Environmental health perspectives 1995;103(3):260-7.
1995: S Chanda; R S Mangipudy; Alan Warbritton; Thomas J Bucci; Harihara M Mehendale
Stimulated hepatic tissue repair underlies heteroprotection by thioacetamide against acetaminophen-induced lethality.
Hepatology (Baltimore, Md.) 1995;21(2):477-86.
1995: S Chanda; Harihara M Mehendale
Nutritional impact on the final outcome of liver injury inflicted by model hepatotoxicants: effect of glucose loading.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1995;9(2):240-5.
1995: D V Sivarao; Harihara M Mehendale
2-Butoxyethanol autoprotection is due to resiliance of newly formed erythrocytes to hemolysis.
Archives of toxicology 1995;69(8):526-32.
1994: Harihara M Mehendale
Amplified interactive toxicity of chemicals at nontoxic levels: mechanistic considerations and implications to public health.
Environmental health perspectives 1994;102 Suppl 9():139-49.
1994: Harihara M Mehendale; K N Thakore; C V Rao
Autoprotection: stimulated tissue repair permits recovery from injury.
Journal of biochemical toxicology 1994;9(3):131-9.
1994: K N Thakore; Harihara M Mehendale
Effect of phenobarbital and mirex pretreatments on CCl4 autoprotection.
Toxicologic pathology 1994;22(3):291-9.
1993: P R Kodavanti; V C Rao; Harihara M Mehendale
Loss of calcium homeostasis leads to progressive phase of chlordecone-potentiated carbon tetrachloride hepatotoxicity.
Toxicology and applied pharmacology 1993;122(1):77-87.
1993: S B Rao; Harihara M Mehendale
Halomethane-chlordecone (CD) interactive hepatotoxicity--current concepts on the mechanism.
Indian journal of biochemistry & biophysics 1993;30(4):191-8.
1993: Z Cai; Harihara M Mehendale
Resiliency to amplification of carbon tetrachloride hepatotoxicity by chlordecone during postnatal development in rats.
Pediatric research 1993;33(3):225-32.
1993: V C Rao; Harihara M Mehendale
Effect of antimitotic agent colchicine on carbon tetrachloride toxicity.
Archives of toxicology 1993;67(6):392-400.
1992: S K Abdul-Hussain; Harihara M Mehendale
Biochemical studies on the age-related toxicity of galactosamine in primary rat hepatocyte cultures.
Toxicology in vitro : an international journal published in association with BIBRA 1992;6(3):183-9.
1992: S K Abdul-Hussain; Harihara M Mehendale
Ongoing hepatocellular regeneration and resiliency toward galactosamine hepatotoxicity.
Archives of toxicology 1992;66(10):729-42.
1992: P R Kodavanti; U P Kodavanti; O M Faroon; Harihara M Mehendale
Pivotal role of hepatocellular regeneration in the ultimate hepatotoxicity of CCl4 in chlordecone-, mirex-, or phenobarbital-pretreated rats.
Toxicologic pathology 1992;20(4):556-69.
1991: C V Rao; Harihara M Mehendale
Effect of colchicine on hepatobiliary function in CCl4 treated rats.
Biochemical pharmacology 1991;42(12):2323-32.
1991: O M Faroon; R W Henry; M G Soni; Harihara M Mehendale
Potentiation of BrCCl3 hepatotoxicity by chlordecone: biochemical and ultrastructural study.
Toxicology and applied pharmacology 1991;110(2):185-97.
1991: Harihara M Mehendale
Role of hepatocellular regeneration and hepatolobular healing in the final outcome of liver injury. A two-stage model of toxicity.
Biochemical pharmacology 1991;42(6):1155-62.
1991: F I Ikegwuonu; Harihara M Mehendale
Biochemical assessment of the genotoxicity of the in vitro interaction between chlordecone and carbon tetrachloride in rat hepatocytes.
Journal of applied toxicology : JAT 1991;11(4):303-10.
1991: Z W Cai; Harihara M Mehendale
Protection from CCl4 toxicity by prestimulation of hepatocellular regeneration in partially hepatectomized gerbils.
Biochemical pharmacology 1991;42(3):633-44.
1991: K N Thakore; M L Gargas; M E Andersen; Harihara M Mehendale
PB-PK derived metabolic constants, hepatotoxicity, and lethality of BrCCl3 in rats pretreated with chlordecone, phenobarbital, or mirex.
Toxicology and applied pharmacology 1991;109(3):514-28.
1991: U P Kodavanti; Harihara M Mehendale
Amiodarone- and desethylamiodarone-induced pulmonary phospholipidosis, inhibition of phospholipases in vivo, and alteration of [14C]amiodarone uptake by perfused lung.
American journal of respiratory cell and molecular biology 1991;4(4):369-78.
1991: M G Soni; Harihara M Mehendale
Protection from chlordecone-amplified carbon tetrachloride toxicity by cyanidanol: regeneration studies.
Toxicology and applied pharmacology 1991;108(1):58-66.
1991: M G Soni; Harihara M Mehendale
Protection from chlordecone-amplified carbon tetrachloride toxicity by cyanidanol: biochemical and histological studies.
Toxicology and applied pharmacology 1991;108(1):46-57.
1991: S K Abdul-Hussain; Harihara M Mehendale
Studies on the age-dependent effects of galactosamine in primary rat hepatocyte cultures.
Toxicology and applied pharmacology 1991;107(3):504-13.
1991: S Chaudhury; Harihara M Mehendale
Amplification of CCl4 toxicity by chlordecone: destruction of rat hepatic microsomal cytochrome P-450 subpopulation.
Journal of toxicology and environmental health 1991;32(3):277-94.
1991: P R Kodavanti; U P Kodavanti; Harihara M Mehendale
Carbon tetrachloride-induced alterations of hepatic calmodulin and free calcium levels in rats pretreated with chlordecone.
Hepatology (Baltimore, Md.) 1991;13(2):230-8.
1991: K N Thakore; Harihara M Mehendale
Role of hepatocellular regeneration in CCl4 autoprotection.
Toxicologic pathology 1991;19(1):47-58.
1991: W S Utley; Harihara M Mehendale
Evidence for stimulated glutathione synthesis by phenobarbital pretreatment during an oxidative challenge in isolated hepatocytes.
Journal of biochemical toxicology 1991;6(2):101-13.
1991: V C Rao; Harihara M Mehendale
Colchicine antimitosis abolishes CCl4 autoprotection.
Toxicologic pathology 1991;19(4 Pt 2):597-606.
1991: M G Soni; Harihara M Mehendale
Hepatoprotective agent (+)-cyanidanol increases the synthetic phase of hepatocellular regeneration.
The International journal of biochemistry 1991;23(12):1369-73.
1991: Z Cai; Harihara M Mehendale
Hepatotoxicity and lethality of halomethanes in Mongolian gerbils pretreated with chlordecone, phenobarbital or mirex.
Archives of toxicology 1991;65(3):204-12.
1990: S B Rao; Harihara M Mehendale
Comparative evaluation of sequestration of polyamines by perfused rabbit and rat lungs.
Indian journal of experimental biology 1990;28(12):1166-70.
1990: U P Kodavanti; Harihara M Mehendale
Cationic amphiphilic drugs and phospholipid storage disorder.
Pharmacological reviews 1990;42(4):327-54.
1990: Harihara M Mehendale
Potentiation of halomethane hepatotoxicity by chlordecone: a hypothesis for the mechanism.
Medical hypotheses 1990;33(4):289-99.
1990: S D Ray; Harihara M Mehendale
Potentiation of CCl4 and CHCl3 hepatotoxicity and lethality by various alcohols.
Fundamental and applied toxicology : official journal of the Society of Toxicology 1990;15(3):429-40.
1990: P R Kodavanti; U P Kodavanti; Harihara M Mehendale
Altered hepatic energy status in chlordecone (Kepone)-potentiated CCl4 hepatotoxicity.
Biochemical pharmacology 1990;40(4):859-66.
1990: Z W Cai; Harihara M Mehendale
Lethal effects of CCl4 and its metabolism by Mongolian gerbils pretreated with chlordecone, phenobarbital, or mirex.
Toxicology and applied pharmacology 1990;104(3):511-20.
1990: Harihara M Mehendale; S D Ray
Inhibition of cell division in hepatoma cell cultures by chlordecone and carbon tetrachloride combination.
Toxicology in vitro : an international journal published in association with BIBRA 1990;4(3):179-83.
1990: U P Kodavanti; V G Lockard; Harihara M Mehendale
In vivo toxicity and pulmonary effects of promazine and chlorpromazine in rats.
Journal of biochemical toxicology 1990;5(4):245-51.
1990: O M Faroon; Harihara M Mehendale
Bromotrichloromethane hepatotoxicity. The role of stimulated hepatocellular regeneration in recovery: biochemical and histopathological studies in control and chlordecone pretreated male rats.
Toxicologic pathology 1990;18(4 Pt 2):667-77.
1990: W S Utley; Harihara M Mehendale
Phenobarbital-induced cytoprotective mechanisms in menadione metabolism: the role of glutathione reductase and DT-diaphorase.
The International journal of biochemistry 1990;22(9):957-67.
1990: S B Rao; R A Young; Harihara M Mehendale
Perturbations in polyamines and related enzymes following chlordecone-potentiated bromotrichloromethane hepatotoxicity.
Journal of biochemical toxicology 1990;5(1):23-32.
1989: R A Young; Harihara M Mehendale
Effects of short-term and long-term administration of amiodarone on hepatobiliary function in male rats.
Journal of applied toxicology : JAT 1989;9(6):407-12.
1989: P R Kodavanti; U M Joshi; Harihara M Mehendale; V G Lockard
Chlordecone (Kepone)-potentiated carbon tetrachloride hepatotoxicity in partially hepatectomized rats--a histomorphometric study.
Journal of applied toxicology : JAT 1989;9(6):367-75.
1989: Harihara M Mehendale
Mechanism of the lethal interaction of chlordecone and CCl4 at non-toxic doses.
Toxicology letters 1989;49(2-3):215-41.
1989: S B Rao; Harihara M Mehendale
Protective role of fructose 1,6-bisphosphate during CCl4 hepatotoxicity in rats.
The Biochemical journal 1989;262(3):721-5.
1989: U M Joshi; P Rao; S Kodavanti; V G Lockard; Harihara M Mehendale
Fluorescence studies on binding of amphiphilic drugs to isolated lamellar bodies: relevance to phospholipidosis.
Biochimica et biophysica acta 1989;1004(3):309-20.
1989: Harihara M Mehendale; K R Purushotham; V G Lockard
The time course of liver injury and [3H]thymidine incorporation in chlordecone-potentiated CHCl3 hepatotoxicity.
Experimental and molecular pathology 1989;51(1):31-47.
1989: W S Utley; Harihara M Mehendale
Phenobarbital-induced cytosolic cytoprotective mechanisms that offset increases in NADPH cytochrome P450 reductase activity in menadione-mediated cytotoxicity.
Toxicology and applied pharmacology 1989;99(2):323-33.
1989: P Camus; U M Joshi; V G Lockard; M F Petrini; D L Lentz; Harihara M Mehendale
Effects of drug-induced pulmonary phospholipidosis on lung mechanics in rats.
Journal of applied physiology (Bethesda, Md. : 1985) 1989;66(5):2437-45.
1989: P R Kodavanti; U M Joshi; R A Young; E F Meydrech; Harihara M Mehendale
Protection of hepatotoxic and lethal effects of CCl4 by partial hepatectomy.
Toxicologic pathology 1989;17(3):494-505.
1989: R A Young; Harihara M Mehendale
Carbon tetrachloride metabolism in partially hepatectomized and sham-operated rats pre-exposed to chlordecone (Kepone).
Journal of biochemical toxicology 1989;4(4):211-9.
1989: S B Rao; Harihara M Mehendale
Protection from chlordecone (Kepone)-potentiated CCl4 hepatotoxicity in rats by fructose 1,6-diphosphate.
The International journal of biochemistry 1989;21(9):949-54.
1989: P R Kodavanti; U M Joshi; R A Young; A N Bell; Harihara M Mehendale
Role of hepatocellular regeneration in chlordecone potentiated hepatotoxicity of carbon tetrachloride.
Archives of toxicology 1989;63(5):367-75.
1989: S B Rao; R A Young; Harihara M Mehendale
Hepatic polyamines and related enzymes following chlordecone-potentiated carbon tetrachloride toxicity in rats.
Journal of biochemical toxicology 1989;4(1):55-63.
1988: U M Joshi; P R Kodavanti; Harihara M Mehendale
Glutathione metabolism and utilization of external thiols by cigarette smoke-challenged, isolated rat and rabbit lungs.
Toxicology and applied pharmacology 1988;96(2):324-35.
1988: S B Rao; Harihara M Mehendale
Passive sequestration of putrescine, spermidine and spermine by rat lungs.
Biochimica et biophysica acta 1988;966(1):22-9.
1988: U M Joshi; P R Kodavanti; B Coudert; Terry M Dwyer; Harihara M Mehendale
Types of interaction of amphiphilic drugs with phospholipid vesicles.
The Journal of pharmacology and experimental therapeutics 1988;246(1):150-7.
1988: A N Bell; R A Young; V G Lockard; Harihara M Mehendale
Protection of chlordecone-potentiated carbon tetrachloride hepatotoxicity and lethality by partial hepatectomy.
Archives of toxicology 1988;61(5):392-405.
1988: Harihara M Mehendale; J S Klingensmith
In vivo metabolism of CCl4 by rats pretreated with chlordecone, mirex, or phenobarbital.
Toxicology and applied pharmacology 1988;93(2):247-56.
1988: K R Purushotham; V G Lockard; Harihara M Mehendale
Amplification of chloroform hepatotoxicity and lethality by dietary chlordecone (kepone) in mice.
Toxicologic pathology 1988;16(1):27-34.
1987: K S Prasada Rao; Harihara M Mehendale
Precursor utilization of 5-hydroxytryptophan for 5-hydroxytryptamine biosynthesis in isolated and perfused rabbit and rat lungs.
Canadian journal of physiology and pharmacology 1987;65(10):2117-23.
1987: R A Young; Harihara M Mehendale
Effect of cytochrome P-450 and flavin-containing monooxygenase modifying factors on the in vitro metabolism of amiodarone by rat and rabbit.
Drug metabolism and disposition: the biological fate of chemicals 1987;15(4):511-7.
1987: U M Joshi; K S Rao; Harihara M Mehendale
Glutathione status in constituted physiological fluids containing albumin.
The International journal of biochemistry 1987;19(11):1029-35.
1981: T P Huang; Ing K Ho; Harihara M Mehendale
Assessment of neurotoxicity induced by oral administration of chlordecone (Kepone) in the mouse.
Neurotoxicology 1981;2(1):113-24.