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John Baxter

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Chaoshen Yuan; John D Baxter; Phuong Nguyen; Paul Webb
Distinct ligand-dependent and independent modes of thyroid hormone receptor (TR)/PGC-1α interaction.
Angélica A Amato; Stephen D Ayers; John D Baxter; Richard G Brennan; Bruno M Carvalho; Ana C M Figueira; Suely L Galdino; M C A Lima; Jean Z Lin; Jenny Lu; Melina Mottin; Rosa H V Mourão; Kevin J Phillips; Ivan R Pitta; Igor Polikparpov; Senapathy Rajagopalan; Mário J A Saad; Rodrigo L Silveira; Luiz Simeoni; Munir S Skaf; Paulo C T Souza; Marie Togashi; Paul Webb; Dulcinéia S P Abdalla; Francisco A R Neves
GQ-16, a novel peroxisome proliferator-activated receptor γ (PPARγ) ligand, promotes insulin sensitization without weight gain.
Solène Grosdidier; Phuong Nguyen; Paul Webb; John D Baxter; Charlotte Bevan; Greg Brooke; Víctor Buzón; Laia R Carbó; Eva Estébanez-Perpiñá; Juan Fernandez-Recio
Allosteric conversation in the androgen receptor ligand-binding domain surfaces.

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All Publications

2013: Chaoshen Yuan; John D Baxter; Phuong Nguyen; Paul Webb
Distinct ligand-dependent and independent modes of thyroid hormone receptor (TR)/PGC-1α interaction.
The Journal of steroid biochemistry and molecular biology 2013;133():58-65.
2012: Angélica A Amato; Stephen D Ayers; John D Baxter; Richard G Brennan; Bruno M Carvalho; Ana C M Figueira; Suely L Galdino; M C A Lima; Jean Z Lin; Jenny Lu; Melina Mottin; Rosa H V Mourão; Kevin J Phillips; Ivan R Pitta; Igor Polikparpov; Senapathy Rajagopalan; Mário J A Saad; Rodrigo L Silveira; Luiz Simeoni; Munir S Skaf; Paulo C T Souza; Marie Togashi; Paul Webb; Dulcinéia S P Abdalla; Francisco A R Neves
GQ-16, a novel peroxisome proliferator-activated receptor γ (PPARγ) ligand, promotes insulin sensitization without weight gain.
The Journal of biological chemistry 2012;287(33):28169-79.
2012: Solène Grosdidier; Phuong Nguyen; Paul Webb; John D Baxter; Charlotte Bevan; Greg Brooke; Víctor Buzón; Laia R Carbó; Eva Estébanez-Perpiñá; Juan Fernandez-Recio
Allosteric conversation in the androgen receptor ligand-binding domain surfaces.
Molecular endocrinology (Baltimore, Md.) 2012;26(7):1078-90.
2011: Ana Carolina M Figueira; D M Saidemberg; P C T Souza; L Martínez; Thomas S Scanlan; John D Baxter; Munir S Skaf; Mario Palma; Paul Webb; Igor Polikarpov
Analysis of agonist and antagonist effects on thyroid hormone receptor conformation by hydrogen/deuterium exchange.
Molecular endocrinology (Baltimore, Md.) 2011;25(1):15-31.
2010: John D Baxter; Laveeza Bhatti; Eoin Coakley; Jennifer Bartczak; Marita McDonough; Richard Vinisko; Peter J Piliero
Susceptibility of HIV-1 to tipranavir and other antiretroviral agents in treatment-experienced patients: The UTILIZE Study.
Current HIV research 2010;8(4):347-54.
2009: Leandro Martínez; Alessandro S Nascimento; Fabio M Nunes; Kevin Phillips; Ricardo Aparicio; Sandra Martha G Dias; Ana Carolina M Figueira; Jean H Lin; Phuong Nguyen; James W Apriletti; Francisco A R Neves; John D Baxter; Paul Webb; Munir S Skaf; Igor Polikarpov
Gaining ligand selectivity in thyroid hormone receptors via entropy.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(49):20717-22.
2009: Suzana T Cunha Lima; Ngoc-Ha Nguyen; Marie Togashi; James W Apriletti; Phuong Nguyen; Igor Polikarpov; Thomas S Scanlan; John D Baxter; Paul Webb
Differential effects of TR ligands on hormone dissociation rates: evidence for multiple ligand entry/exit pathways.
The Journal of steroid biochemistry and molecular biology 2009;117(4-5):125-31.
2009: Natalia Jouravel; Elena Sablin; Marie Togashi; John D Baxter; Paul Webb; Robert J Fletterick
Molecular basis for dimer formation of TRbeta variant D355R.
Proteins 2009;75(1):111-7.
2009: Birgitte Simen; Jan Fredrik Simons; Katherine Huppler Hullsiek; Richard M Novak; Rodger D MacArthur; John D Baxter; Chunli Huang; Christine Lubeski; Gregory S Turenchalk; Michael S Braverman; Brian Desany; Jonathan M Rothberg; Michael Egholm; Michael J Kozal
Low-abundance drug-resistant viral variants in chronically HIV-infected, antiretroviral treatment-naive patients significantly impact treatment outcomes.
The Journal of infectious diseases 2009;199(5):693-701.
2008: Vanya Shah; Phuong Nguyen; Ngoc-Ha Nguyen; Marie Togashi; Thomas S Scanlan; John D Baxter; Paul Webb
Complex actions of thyroid hormone receptor antagonist NH-3 on gene promoters in different cell lines.
Molecular and cellular endocrinology 2008;296(1-2):69-77.
2008: Galina Bryzgalova; Suad Effendic; Akhtar Khan; Stefan Rehnmark; Peter Barbounis; Jamie Boulet; Gao Dong; Rajni Singh; Sue Shapses; Johan Malm; Paul Webb; John D Baxter; Gary J Grover
Anti-obesity, anti-diabetic, and lipid lowering effects of the thyroid receptor beta subtype selective agonist KB-141.
The Journal of steroid biochemistry and molecular biology 2008;111(3-5):262-7.
2008: Rose Kim; John D Baxter
Protease inhibitor resistance update: where are we now?
AIDS patient care and STDs 2008;22(4):267-77.
2008: Anders Berkenstam; Jens Kristensen; Karin Mellström; Bo Carlsson; Johan Malm; Stefan Rehnmark; Neeraj Garg; Carl Magnus Andersson; Mats Rudling; Folke Sjöberg; Bo Angelin; John D Baxter
The thyroid hormone mimetic compound KB2115 lowers plasma LDL cholesterol and stimulates bile acid synthesis without cardiac effects in humans.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(2):663-7.
2008: Lucas Bleicher; Ricardo Aparicio; Fabio M Nunes; Leandro Martinez; Sandra M Gomes Dias; Ana Carolina M Figueira; Maria A M Santos; Walter H Venturelli; Rosangela da Silva; Paulo Marcos Donate; Francisco A R Neves; Luiz Simeoni; John D Baxter; Paul Webb; Munir S Skaf; Igor Polikarpov
Structural basis of GC-1 selectivity for thyroid hormone receptor isoforms.
BMC structural biology 2008;8():8.
2007: Eva Estébanez-Perpiñá; Leggy Arnold; Natalia Jouravel; Marie Togashi; Justin Blethrow; Ellena Mar; Phuong Nguyen; Kevin J Phillips; John D Baxter; Paul Webb; R Kiplin Guy; Robert J Fletterick
Structural insight into the mode of action of a direct inhibitor of coregulator binding to the thyroid hormone receptor.
Molecular endocrinology (Baltimore, Md.) 2007;21(12):2919-28.
2007: Michael J Kozal; Katherine Huppler Hullsiek; Rodger D MacArthur; Mary van den Berg-Wolf; Grace Peng; Ying Xiang; John D Baxter; Jonathan Uy; Edward Telzak; Richard M Novak
The Incidence of HIV drug resistance and its impact on progression of HIV disease among antiretroviral-naïve participants started on three different antiretroviral therapy strategies.
HIV clinical trials 2007;8(6):357-70.
2007: Eva Estébanez-Perpiñá; Leggy Arnold; Alexander A Arnold; Phuong Nguyen; Edson Delgado Rodrigues; Ellena Mar; Raynard Bateman; Peter Pallai; Kevan M Shokat; John D Baxter; R Kiplin Guy; Paul Webb; Robert J Fletterick
A surface on the androgen receptor that allosterically regulates coactivator binding.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(41):16074-9.
2007: Lara F R Velasco; Marie Togashi; Paul G Walfish; Rutinéia P Pessanha; Fanny N Moura; Gustavo B Barra; Phuong Nguyen; Rachelle Rebong; Chaoshen Yuan; Luiz Simeoni; Ralff C J Ribeiro; John D Baxter; Paul Webb; Francisco A R Neves
Thyroid hormone response element organization dictates the composition of active receptor.
The Journal of biological chemistry 2007;282(17):12458-66.
2007: Ana Carolina M Figueira; Mario de Oliveira Neto; Amanda Bernardes; Sandra M G Dias; Aldo F Craievich; John D Baxter; Paul Webb; Igor Polikarpov
Low-resolution structures of thyroid hormone receptor dimers and tetramers in solution.
Biochemistry 2007;46(5):1273-83.
2006: John D Baxter; Jonathan M Schapiro; Charles A B Boucher; Veronika M Kohlbrenner; David B Hall; Joseph R Scherer; Douglas Mayers
Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir.
Journal of virology 2006;80(21):10794-801.
2006: Jody Lawrence; Katherine Huppler Hullsiek; Lisa M Thackeray; Donald I Abrams; Lawrence R Crane; Douglas Mayers; Michael C Jones; Jennifer M Saldanha; Barry Schmetter; John D Baxter
Disadvantages of structured treatment interruption persist in patients with multidrug-resistant HIV-1: final results of the CPCRA 064 study.
Journal of acquired immune deficiency syndromes (1999) 2006;43(2):169-78.
2006: Alessandro S Nascimento; Sandra M G Dias; Fábio M Nunes; Ricardo Aparício; Andre L B Ambrosio; Lucas Bleicher; Ana Carolina M Figueira; Maria A M Santos; Mário de Oliveira Neto; Hannes Fischer; Marie Togashi; Aldo F Craievich; Richard C Garratt; John D Baxter; Paul Webb; Igor Polikarpov
Structural rearrangements in the thyroid hormone receptor hinge domain and their putative role in the receptor function.
Journal of molecular biology 2006;360(3):586-98.
2006: Leggy Arnold; Eva Estébanez-Perpiñá; Marie Togashi; Anang A Shelat; Cory Ocasio; Andrea C McReynolds; Phuong Nguyen; John D Baxter; Robert J Fletterick; Paul Webb; R Kiplin Guy
A high-throughput screening method to identify small molecule inhibitors of thyroid hormone receptor coactivator binding.
Science's STKE : signal transduction knowledge environment 2006;2006(341):pl3.
2006: Xianwang Meng; Vishnuka D Arulsundaram; Ahmed F Yousef; Paul Webb; John D Baxter; Joe S Mymryk; Paul G Walfish
Corepressor/coactivator paradox: potential constitutive coactivation by corepressor splice variants.
Nuclear receptor signaling 2006;4():e022.
2006: Michael J Kozal; Katherine Huppler Hullsiek; Robert Leduc; Richard M Novak; Rodger D MacArthur; Jody Lawrence; John D Baxter
Prevalence and impact of HIV-1 protease codon 33 mutations and polymorphisms in treatment-naive and treatment-experienced patients.
Antiviral therapy 2006;11(4):457-63.
2006: Ana Carolina M Figueira; Sandra M G Dias; Maria A M Santos; James W Apriletti; John D Baxter; Paul Webb; Francisco A R Neves; Luiz Simeoni; Ralff C J Ribeiro; Igor Polikarpov
Human thyroid receptor forms tetramers in solution, which dissociate into dimers upon ligand binding.
Cell biochemistry and biophysics 2006;44(3):453-62.
2005: Leggy Arnold; Eva Estébanez-Perpiñá; Marie Togashi; Natalia Jouravel; Anang A Shelat; Andrea C McReynolds; Ellena Mar; Phuong Nguyen; John D Baxter; Robert J Fletterick; Paul Webb; R Kiplin Guy
Discovery of small molecule inhibitors of the interaction of the thyroid hormone receptor with transcriptional coregulators.
The Journal of biological chemistry 2005;280(52):43048-55.
2005: Bernd Gloss; Gisele Giannocco; Eric A Swanson; Anselmo S Moriscot; Grazia Chiellini; Thomas S Scanlan; John D Baxter; Wolfgang H Dillmann
Different configurations of specific thyroid hormone response elements mediate opposite effects of thyroid hormone and GC-1 on gene expression.
Endocrinology 2005;146(11):4926-33.
2005: Marie Togashi; Phuong Nguyen; Robert J Fletterick; John D Baxter; Paul Webb
Rearrangements in thyroid hormone receptor charge clusters that stabilize bound 3,5',5-triiodo-L-thyronine and inhibit homodimer formation.
The Journal of biological chemistry 2005;280(27):25665-73.
2005: Xianwang Meng; Paul Webb; Yong-Fan Yang; Michael Shuen; Ahmed F Yousef; John D Baxter; Joe S Mymryk; Paul G Walfish
E1A and a nuclear receptor corepressor splice variant (N-CoRI) are thyroid hormone receptor coactivators that bind in the corepressor mode.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(18):6267-72.
2005: Rodger D MacArthur; George Perez; Sharon Walmsley; John D Baxter; Christopher M Mullin; James D Neaton
Comparison of prognostic importance of latest CD4+ cell count and HIV RNA levels in patients with advanced HIV infection on highly active antiretroviral therapy.
HIV clinical trials 2005;6(3):127-35.
2005: Ngoc-Ha Nguyen; James W Apriletti; John D Baxter; Thomas S Scanlan
Hammett analysis of selective thyroid hormone receptor modulators reveals structural and electronic requirements for hormone antagonists.
Journal of the American Chemical Society 2005;127(13):4599-608.
2005: Eva Estébanez-Perpiñá; Jamie M R Moore; Ellena Mar; Edson Delgado-Rodrigues; Phuong Nguyen; John D Baxter; Benjamin M Buehrer; Paul Webb; Robert J Fletterick; R Kiplin Guy
The molecular mechanisms of coactivator utilization in ligand-dependent transactivation by the androgen receptor.
The Journal of biological chemistry 2005;280(9):8060-8.
2005: Marie Togashi; Sabine Borngraeber; Ben Sandler; Robert J Fletterick; Paul Webb; John D Baxter
Conformational adaptation of nuclear receptor ligand binding domains to agonists: potential for novel approaches to ligand design.
The Journal of steroid biochemistry and molecular biology 2005;93(2-5):127-37.
2005: Richard M Novak; Li Chen; Rodger D MacArthur; John D Baxter; Kathy Huppler Hullsiek; Grace Peng; Ying Xiang; Christopher Henely; Barry Schmetter; Jonathan Uy; Mary van den Berg-Wolf; Michael J Kozal
Prevalence of antiretroviral drug resistance mutations in chronically HIV-infected, treatment-naive patients: implications for routine resistance screening before initiation of antiretroviral therapy.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2005;40(3):468-74.
2004: Ben Sandler; Paul Webb; James W Apriletti; B Russell Huber; Marie Togashi; Suzana T Cunha Lima; Sanja Juric; Stefan Nilsson; Richard Wagner; Robert J Fletterick; John D Baxter
Thyroxine-thyroid hormone receptor interactions.
The Journal of biological chemistry 2004;279(53):55801-8.
2004: F M Nunes; Ricardo Aparicio; M A M Santos; Rodrigo V Portugal; Sandra M G Dias; Francisco A R Neves; Luiz Simeoni; John D Baxter; Paul Webb; Igor Polikarpov
Crystallization and preliminary X-ray diffraction studies of isoform alpha1 of the human thyroid hormone receptor ligand-binding domain.
Acta crystallographica. Section D, Biological crystallography 2004;60(Pt 10):1867-70.
2004: Maria C S Rodrigues; Guilherme M Santos; C Aluízio da Silva; John D Baxter; Paul Webb; Noureddine Lomri; Francisco A R Neves; Ralff C J Ribeiro; Luiz Simeoni
Thyroid hormone transport is disturbed in erythrocytes from patients with chronic renal failure on hemodialysis.
Renal failure 2004;26(4):461-6.
2004: Gary J Grover; Donald M Egan; Paul G Sleph; Blake C Beehler; Grazia Chiellini; Ngoc-Ha Nguyen; John D Baxter; Thomas S Scanlan
Effects of the thyroid hormone receptor agonist GC-1 on metabolic rate and cholesterol in rats and primates: selective actions relative to 3,5,3'-triiodo-L-thyronine.
Endocrinology 2004;145(4):1656-61.
2004: John D Baxter; John W Funder; James W Apriletti; Paul Webb
Towards selectively modulating mineralocorticoid receptor function: lessons from other systems.
Molecular and cellular endocrinology 2004;217(1-2):151-65.
2003: Sabine Borngraeber; Mary-Jane Budny; Grazia Chiellini; Suzana T Cunha Lima; Marie Togashi; Paul Webb; John D Baxter; Thomas S Scanlan; Robert J Fletterick
Ligand selectivity by seeking hydrophobicity in thyroid hormone receptor.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(26):15358-63.
2003: Jody Lawrence; Douglas Mayers; Katherine Huppler Hullsiek; Gary Collins; Donald I Abrams; Ronald B Reisler; Lawrence R Crane; Barry Schmetter; Thomas J Dionne; Jennifer M Saldanha; Michael C Jones; John D Baxter
Structured treatment interruption in patients with multidrug-resistant human immunodeficiency virus.
The New England journal of medicine 2003;349(9):837-46.
2003: Gary J Grover; Karin Mellström; Liu Ye; Johan Malm; Yi-Lin Li; Lars-Göran Bladh; Paul G Sleph; Mark A Smith; Rocco George; Björn Vennström; Kasim A Mookhtiar; Ryan Horvath; Jessica Speelman; Donald Egan; John D Baxter
Selective thyroid hormone receptor-beta activation: a strategy for reduction of weight, cholesterol, and lipoprotein (a) with reduced cardiovascular liability.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(17):10067-72.
2003: Hikari A I Yoshihara; James W Apriletti; John D Baxter; Thomas S Scanlan
Structural determinants of selective thyromimetics.
Journal of medicinal chemistry 2003;46(14):3152-61.
2003: John D Baxter; William F Young; Paul Webb
Cardiovascular endocrinology: introduction.
Endocrine reviews 2003;24(3):253-60.
2003: Hannes Fischer; Sandra M G Dias; Maria A M Santos; Adriana C Alves; Nilson Zanchin; Aldo F Craievich; James W Apriletti; John D Baxter; Paul Webb; Francisco A R Neves; Ralff C J Ribeiro; Igor Polikarpov
Low resolution structures of the retinoid X receptor DNA-binding and ligand-binding domains revealed by synchrotron X-ray solution scattering.
The Journal of biological chemistry 2003;278(18):16030-8.
2003: B Russell Huber; Ben Sandler; Brian L West; Suzana T Cunha Lima; Hoa T Nguyen; James W Apriletti; John D Baxter; Robert J Fletterick
Two resistance to thyroid hormone mutants with impaired hormone binding.
Molecular endocrinology (Baltimore, Md.) 2003;17(4):643-52.
2003: B Russell Huber; Marion Desclozeaux; Brian L West; Suzana T Cunha Lima; Hoa T Nguyen; John D Baxter; Holly A Ingraham; Robert J Fletterick
Thyroid hormone receptor-beta mutations conferring hormone resistance and reduced corepressor release exhibit decreased stability in the N-terminal ligand-binding domain.
Molecular endocrinology (Baltimore, Md.) 2003;17(1):107-16.
2002: Paul Webb; Ngoc-Ha Nguyen; Grazia Chiellini; Hikari A I Yoshihara; Suzana T Cunha Lima; James W Apriletti; Ralff C J Ribeiro; Adhirai Marimuthu; Brian L West; Patrick Goede; Karin Mellström; Stefan Nilsson; Peter J Kushner; Robert J Fletterick; Thomas S Scanlan; John D Baxter
Design of thyroid hormone receptor antagonists from first principles.
The Journal of steroid biochemistry and molecular biology 2002;83(1-5):59-73.
2002: Ngoc-Ha Nguyen; James W Apriletti; Suzana T Cunha Lima; Paul Webb; John D Baxter; Thomas S Scanlan
Rational design and synthesis of a novel thyroid hormone antagonist that blocks coactivator recruitment.
Journal of medicinal chemistry 2002;45(15):3310-20.
2002: John D Baxter; Thomas C Merigan; Deborah N Wentworth; James D Neaton; Marie L Hoover; Richard Hoetelmans; Stephen C Piscitelli; Werner H A Verbiest; Douglas Mayers
Both baseline HIV-1 drug resistance and antiretroviral drug levels are associated with short-term virologic responses to salvage therapy.
AIDS (London, England) 2002;16(8):1131-8.
2002: RV Weatherman; C-Y Chang; Nancy J Clegg; D C Carroll; Richard N Day; John D Baxter; D P McDonnell; Thomas S Scanlan; Fred Schaufele
Ligand-selective interactions of ER detected in living cells by fluorescence resonance energy transfer.
Molecular endocrinology (Baltimore, Md.) 2002;16(3):487-96.
2002: Adhirai Marimuthu; Weijun Feng; Tetsuya Tagami; Hoa Nguyen; J Larry Jameson; Robert J Fletterick; John D Baxter; Brian L West
TR surfaces and conformations required to bind nuclear receptor corepressor.
Molecular endocrinology (Baltimore, Md.) 2002;16(2):271-86.
2002: John D Baxter; Patrick Goede; James W Apriletti; Brian L West; Weijun Feng; Karin Mellström; Robert J Fletterick; Richard L Wagner; Peter J Kushner; Ralff C J Ribeiro; Paul Webb; Thomas S Scanlan; Stefan Nilsson
Structure-based design and synthesis of a thyroid hormone receptor (TR) antagonist.
Endocrinology 2002;143(2):517-24.
2002: Francisco A R Neves; Ralph R Cavalieri; Luiz Simeoni; David G Gardner; John D Baxter; Bruce F Scharschmidt; Noureddine Lomri; Ralff C J Ribeiro
Thyroid hormone export varies among primary cells and appears to differ from hormone uptake.
Endocrinology 2002;143(2):476-83.
2002: Grazia Chiellini; Ngoc-Ha Nguyen; James W Apriletti; John D Baxter; Thomas S Scanlan
Synthesis and biological activity of novel thyroid hormone analogues: 5'-aryl substituted GC-1 derivatives.
Bioorganic & medicinal chemistry 2002;10(2):333-46.
2001: Hikari A I Yoshihara; James W Apriletti; John D Baxter; Thomas S Scanlan
A designed antagonist of the thyroid hormone receptor.
Bioorganic & medicinal chemistry letters 2001;11(21):2821-5.
2001: Ralff C J Ribeiro; Weijun Feng; Richard L Wagner; C H Costa; A C Pereira; James W Apriletti; Robert J Fletterick; John D Baxter
Definition of the surface in the thyroid hormone receptor ligand binding domain for association as homodimers and heterodimers with retinoid X receptor.
The Journal of biological chemistry 2001;276(18):14987-95.
2001: Richard L Wagner; B Russell Huber; A K Shiau; A Kelly; Suzana T Cunha Lima; Thomas S Scanlan; James W Apriletti; John D Baxter; Brian L West; Robert J Fletterick
Hormone selectivity in thyroid hormone receptors.
Molecular endocrinology (Baltimore, Md.) 2001;15(3):398-410.
2001: John D Baxter; W H Dillmann; Brian L West; R Huber; J David Furlow; Robert J Fletterick; Paul Webb; James W Apriletti; Thomas S Scanlan
Selective modulation of thyroid hormone receptor action.
The Journal of steroid biochemistry and molecular biology 2001;76(1-5):31-42.
2000: Fred Schaufele; C Y Chang; W Liu; John D Baxter; Steven K Nordeen; Yihong Wan; Richard N Day; D P McDonnell
Temporally distinct and ligand-specific recruitment of nuclear receptor-interacting peptides and cofactors to subnuclear domains containing the estrogen receptor.
Molecular endocrinology (Baltimore, Md.) 2000;14(12):2024-39.
2000: Paul Webb; C M Anderson; Cathleen D Valentine; Phuong Nguyen; Adhirai Marimuthu; Brian L West; John D Baxter; Peter J Kushner
The nuclear receptor corepressor (N-CoR) contains three isoleucine motifs (I/LXXII) that serve as receptor interaction domains (IDs).
Molecular endocrinology (Baltimore, Md.) 2000;14(12):1976-85.
2000: Susanne U Trost; Eric Swanson; Bernd Gloss; D B Wang-Iverson; H Zhang; T Volodarsky; Gary J Grover; John D Baxter; Grazia Chiellini; Thomas S Scanlan; Wolfgang H Dillmann
The thyroid hormone receptor-beta-selective agonist GC-1 differentially affects plasma lipids and cardiac activity.
Endocrinology 2000;141(9):3057-64.
2000: John D Baxter; Douglas Mayers; Deborah N Wentworth; James D Neaton; Marie L Hoover; Mark A Winters; S B Mannheimer; M A Thompson; Donald I Abrams; B J Brizz; John Ioannidis; Thomas C Merigan
A randomized study of antiretroviral management based on plasma genotypic antiretroviral resistance testing in patients failing therapy. CPCRA 046 Study Team for the Terry Beirn Community Programs for Clinical Research on AIDS.
AIDS (London, England) 2000;14(9):F83-93.
2000: Mark A Winters; John D Baxter; Douglas Mayers; Deborah N Wentworth; Marie L Hoover; James D Neaton; Thomas C Merigan
Frequency of antiretroviral drug resistance mutations in HIV-1 strains from patients failing triple drug regimens. The Terry Beirn Community Programs for Clinical Research on AIDS.
Antiviral therapy 2000;5(1):57-63.
1999: Jinping An; Ralff C J Ribeiro; Paul Webb; J A Gustafsson; Peter J Kushner; John D Baxter; Dale C Leitman
Estradiol repression of tumor necrosis factor-alpha transcription requires estrogen receptor activation function-2 and is enhanced by coactivators.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(26):15161-6.
1999: Ralph R Cavalieri; Luiz Simeoni; S W Park; John D Baxter; Bruce F Scharschmidt; Ralff C J Ribeiro; Noureddine Lomri
Thyroid hormone export in rat FRTL-5 thyroid cells and mouse NIH-3T3 cells is carrier-mediated, verapamil-sensitive, and stereospecific.
Endocrinology 1999;140(11):4948-54.
1999: Gabriela N Lopez; Paul Webb; J H Shinsako; John D Baxter; Geoffrey L Greene; Peter J Kushner
Titration by estrogen receptor activation function-2 of targets that are downstream from coactivators.
Molecular endocrinology (Baltimore, Md.) 1999;13(6):897-909.
1999: Keith G Duncan; MD Jumper; Ralff C J Ribeiro; Kathy R Bailey; Paul M Yen; A Sugawara; A Patel; Robert Stern; W W Chin; John D Baxter; Daniel M Schwartz
Human trabecular meshwork cells as a thyroid hormone target tissue: presence of functional thyroid hormone receptors.
Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv für klinische und experimentelle Ophthalmologie 1999;237(3):231-40.
1999: Keith G Duncan; Kathy R Bailey; John D Baxter; Daniel M Schwartz
The human fetal retinal pigment epithelium: A target tissue for thyroid hormones.
Ophthalmic research 1999;31(6):399-406.
1998: James W Apriletti; Ralff C J Ribeiro; Richard L Wagner; Weijun Feng; Paul Webb; Peter J Kushner; Brian L West; Stefan Nilsson; Thomas S Scanlan; Robert J Fletterick; John D Baxter
Molecular and structural biology of thyroid hormone receptors.
Clinical and experimental pharmacology & physiology. Supplement 1998;25():S2-11.
1998: Beatrice D Darimont; Richard L Wagner; James W Apriletti; Michael R Stallcup; Peter J Kushner; John D Baxter; Robert J Fletterick; Keith R Yamamoto
Structure and specificity of nuclear receptor-coactivator interactions.
Genes & development 1998;12(21):3343-56.
1998: Weijun Feng; Ralff C J Ribeiro; Richard L Wagner; Hoa Nguyen; James W Apriletti; Robert J Fletterick; John D Baxter; Peter J Kushner; Brian L West
Hormone-dependent coactivator binding to a hydrophobic cleft on nuclear receptors.
Science (New York, N.Y.) 1998;280(5370):1747-9.
1998: Grazia Chiellini; James W Apriletti; Hikari A I Yoshihara; John D Baxter; Ralff C J Ribeiro; Thomas S Scanlan
A high-affinity subtype-selective agonist ligand for the thyroid hormone receptor.
Chemistry & biology 1998;5(6):299-306.
1998: Ralff C J Ribeiro; James W Apriletti; Richard L Wagner; Weijun Feng; Peter J Kushner; Stefan Nilsson; Thomas S Scanlan; Brian L West; Robert J Fletterick; John D Baxter
X-ray crystallographic and functional studies of thyroid hormone receptor.
The Journal of steroid biochemistry and molecular biology 1998;65(1-6):133-41.
1998: Ralff C J Ribeiro; James W Apriletti; Richard L Wagner; Brian L West; Weijun Feng; Robert Huber; Peter J Kushner; Stefan Nilsson; Thomas S Scanlan; Robert J Fletterick; Fred Schaufele; John D Baxter
Mechanisms of thyroid hormone action: insights from X-ray crystallographic and functional studies.
Recent progress in hormone research 1998;53():351-92; discussion 392-4.
1997: F M Chuang; Brian L West; John D Baxter; Fred Schaufele
Activities in Pit-1 determine whether receptor interacting protein 140 activates or inhibits Pit-1/nuclear receptor transcriptional synergy.
Molecular endocrinology (Baltimore, Md.) 1997;11(9):1332-41.
1997: F Saatcioglu; G Lopez; Brian L West; E Zandi; Weijun Feng; H Lu; A Esmaili; James W Apriletti; Peter J Kushner; John D Baxter; Michael Karin
Mutations in the conserved C-terminal sequence in thyroid hormone receptor dissociate hormone-dependent activation from interference with AP-1 activity.
Molecular and cellular biology 1997;17(8):4687-95.
1996: Dale C Leitman; C H Costa; H Graf; John D Baxter; Ralff C J Ribeiro
Thyroid hormone activation of transcription is potentiated by activators of cAMP-dependent protein kinase.
The Journal of biological chemistry 1996;271(36):21950-5.
1996: V Brechler; W N Chu; John D Baxter; G Thibault; Timothy L Reudelhuber
A protease processing site is essential for prorenin sorting to the regulated secretory pathway.
The Journal of biological chemistry 1996;271(34):20636-40.
1996: W Chang; W Zhou; L E Theill; John D Baxter; Fred Schaufele
An activation function in Pit-1 required selectively for synergistic transcription.
The Journal of biological chemistry 1996;271(30):17733-8.
1996: Ralff C J Ribeiro; R R Cavalieri; Noureddine Lomri; C M Rahmaoui; John D Baxter; Bruce F Scharschmidt
Thyroid hormone export regulates cellular hormone content and response.
The Journal of biological chemistry 1996;271(29):17147-51.
1996: F A Neves; Keith G Duncan; John D Baxter
Cathepsin B is a prorenin processing enzyme.
Hypertension 1996;27(3 Pt 2):514-7.
1995: Richard L Wagner; James W Apriletti; M E McGrath; Brian L West; John D Baxter; Robert J Fletterick
A structural role for hormone in the thyroid hormone receptor.
Nature 1995;378(6558):690-7.
1995: Ralff C J Ribeiro; James W Apriletti; Brian L West; Richard L Wagner; Robert J Fletterick; Fred Schaufele; John D Baxter
The molecular biology of thyroid hormone action.
Annals of the New York Academy of Sciences 1995;758():366-89.
1995: James W Apriletti; John D Baxter; K H Lau; Brian L West
Expression of the rat alpha 1 thyroid hormone receptor ligand binding domain in Escherichia coli and the use of a ligand-induced conformation change as a method for its purification to homogeneity.
Protein expression and purification 1995;6(3):363-70.
1995: Y Sadovsky; Paul Webb; Gabriela N Lopez; John D Baxter; P M Fitzpatrick; E Gizang-Ginsberg; V Cavailles; M G Parker; Peter J Kushner
Transcriptional activators differ in their responses to overexpression of TATA-box-binding protein.
Molecular and cellular biology 1995;15(3):1554-63.
1994: Ralff C J Ribeiro; James W Apriletti; Paul M Yen; William W Chin; John D Baxter
Heterodimerization and deoxyribonucleic acid-binding properties of a retinoid X receptor-related factor.
Endocrinology 1994;135(5):2076-85.
1994: Peter J Kushner; John D Baxter; Keith G Duncan; Gabriela N Lopez; Fred Schaufele; Rosalie M Uht; Paul Webb; Brian L West
Eukaryotic regulatory elements lurking in plasmid DNA: the activator protein-1 site in pUC.
Molecular endocrinology (Baltimore, Md.) 1994;8(4):405-7.
1994: M E McGrath; Richard L Wagner; James W Apriletti; Brian L West; V Ramalingam; John D Baxter; Robert J Fletterick
Preliminary crystallographic studies of the ligand-binding domain of the thyroid hormone receptor complexed with triiodothyronine.
Journal of molecular biology 1994;237(2):236-9.
1994: Paul M Yen; J H Brubaker; James W Apriletti; John D Baxter; William W Chin
Roles of 3,5,3'-triiodothyronine and deoxyribonucleic acid binding on thyroid hormone receptor complex formation.
Endocrinology 1994;134(3):1075-81.
1994: A Sugawara; Paul M Yen; James W Apriletti; Ralff C J Ribeiro; David B Sacks; John D Baxter; William W Chin
Phosphorylation selectively increases triiodothyronine receptor homodimer binding to DNA.
The Journal of biological chemistry 1994;269(1):433-7.
1993: Gabriela N Lopez; Fred Schaufele; Paul Webb; J M Holloway; John D Baxter; Peter J Kushner
Positive and negative modulation of Jun action by thyroid hormone receptor at a unique AP1 site.
Molecular and cellular biology 1993;13(5):3042-9.
1992: W N Chu; Chantal Mercure; John D Baxter; Timothy L Reudelhuber
Molecular determinants of human prorenin processing.
Hypertension 1992;20(6):782-7.
1992: W Zhang; R L Brooks; D W Silversides; Brian L West; F Leidig; John D Baxter; Norman L Eberhardt
Negative thyroid hormone control of human growth hormone gene expression is mediated by 3'-untranslated/3'-flanking DNA.
The Journal of biological chemistry 1992;267(21):15056-63.
1992: Ralff C J Ribeiro; Peter J Kushner; James W Apriletti; Brian L West; John D Baxter
Thyroid hormone alters in vitro DNA binding of monomers and dimers of thyroid hormone receptors.
Molecular endocrinology (Baltimore, Md.) 1992;6(7):1142-52.
1992: Fred Schaufele; Brian L West; John D Baxter
Synergistic activation of the rat growth hormone promoter by Pit-1 and the thyroid hormone receptor.
Molecular endocrinology (Baltimore, Md.) 1992;6(4):656-65.
1992: Dale C Leitman; E R Mackow; T Williams; John D Baxter; Brian L West
The core promoter region of the tumor necrosis factor alpha gene confers phorbol ester responsiveness to upstream transcriptional activators.
Molecular and cellular biology 1992;12(3):1352-6.
1992: Paul Webb; Gabriela N Lopez; G L Greene; John D Baxter; Peter J Kushner
The limits of the cellular capacity to mediate an estrogen response.
Molecular endocrinology (Baltimore, Md.) 1992;6(2):157-67.
1992: F Leidig; A R Shepard; W G Zhang; A Stelter; Peter A Cattini; John D Baxter; Norman L Eberhardt
Thyroid hormone responsiveness in human growth hormone-related genes. Possible correlation with receptor-induced DNA conformational changes.
The Journal of biological chemistry 1992;267(2):913-21.
1991: Dale C Leitman; Ralff C J Ribeiro; E R Mackow; John D Baxter; Brian L West
Identification of a tumor necrosis factor-responsive element in the tumor necrosis factor alpha gene.
The Journal of biological chemistry 1991;266(15):9343-6.
1991: John D Baxter; K Duncan; W Chu; M N James; R B Russell; M A Haidar; F M DeNoto; W Hsueh; Timothy L Reudelhuber
Molecular biology of human renin and its gene.
Recent progress in hormone research 1991;47():211-57; discussion 257-8.
1990: W N Chu; John D Baxter; Timothy L Reudelhuber
A targeting sequence for dense secretory granules resides in the active renin protein moiety of human preprorenin.
Molecular endocrinology (Baltimore, Md.) 1990;4(12):1905-13.
1990: Keith G Duncan; M A Haidar; John D Baxter; Timothy L Reudelhuber
Regulation of human renin expression in chorion cell primary cultures.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(19):7588-92.
1990: Peter J Kushner; E Hort; J Shine; John D Baxter; G L Greene
Construction of cell lines that express high levels of the human estrogen receptor and are killed by estrogens.
Molecular endocrinology (Baltimore, Md.) 1990;4(10):1465-73.
1990: F Leidig; John D Baxter; Norman L Eberhardt
Thyroid hormone receptors induce DNA bending: potential importance for receptor action.
Transactions of the Association of American Physicians 1990;103():154-62.
1989: John D Baxter; M N James; W N Chu; K Duncan; M A Haidar; C T Carilli; Timothy L Reudelhuber
The molecular biology of human renin and its gene.
The Yale journal of biology and medicine 1989;62(5):493-501.
1989: M F Norman; T N Lavin; John D Baxter; Brian L West
The rat growth hormone gene contains multiple thyroid response elements.
The Journal of biological chemistry 1989;264(20):12063-73.
1988: James W Apriletti; John D Baxter; T N Lavin
Large scale purification of the nuclear thyroid hormone receptor from rat liver and sequence-specific binding of the receptor to DNA.
The Journal of biological chemistry 1988;263(19):9409-17.
1988: T N Lavin; John D Baxter; S Horita
The thyroid hormone receptor binds to multiple domains of the rat growth hormone 5'-flanking sequence.
The Journal of biological chemistry 1988;263(19):9418-26.
1988: L N Peritz; E J Fodor; D W Silversides; Peter A Cattini; John D Baxter; Norman L Eberhardt
The human growth hormone gene contains both positive and negative control elements.
The Journal of biological chemistry 1988;263(11):5005-7.
1987: B J Gertz; David G Gardner; John D Baxter
Glucocorticoid control of rat growth hormone gene expression: effect on cytoplasmic messenger ribonucleic acid production and degradation.
Molecular endocrinology (Baltimore, Md.) 1987;1(12):933-41.
1987: L C Fritz; M A Haidar; Ann E Arfsten; J W Schilling; C Carilli; J Shine; John D Baxter; Timothy L Reudelhuber
Human renin is correctly processed and targeted to the regulated secretory pathway in mouse pituitary AtT-20 cells.
The Journal of biological chemistry 1987;262(26):12409-12.
1987: R E Isaacs; P R Findell; P Mellon; C B Wilson; John D Baxter
Hormonal regulation of expression of the endogenous and transfected human growth hormone gene.
Molecular endocrinology (Baltimore, Md.) 1987;1(8):569-76.
1987: Keith G Duncan; M A Haidar; John D Baxter; Timothy L Reudelhuber
Control elements in the human renin gene.
Transactions of the Association of American Physicians 1987;100():1-9.
1986: Willa A Hsueh; Y S Do; T Shinagawa; H Tam; P A Ponte; John D Baxter; J Shine; L C Fritz
Biochemical similarity of expressed human prorenin and native inactive renin.
Hypertension 1986;8(6 Pt 2):II78-83.
1986: L C Fritz; Ann E Arfsten; V J Dzau; S A Atlas; John D Baxter; J C Fiddes; J Shine; C L Cofer; Peter J Kushner; P A Ponte
Characterization of human prorenin expressed in mammalian cells from cloned cDNA.
Proceedings of the National Academy of Sciences of the United States of America 1986;83(12):4114-8.