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Edward Meighen

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Tom Defoirdt; Carol M Miyamoto; Thomas K Wood; Edward A Meighen; Patrick Sorgeloos; Willy Verstraete; Peter Bossier
The natural furanone (5Z)-4-bromo-5-(bromomethylene)-3-butyl-2(5H)-furanone disrupts quorum sensing-regulated gene expression in Vibrio harveyi by decreasing the DNA-binding activity of the transcriptional regulator protein luxR.
Carol M Miyamoto; Edward A Meighen
Involvement of LuxR, a quorum sensing regulator in Vibrio harveyi, in the promotion of metabolic genes: argA, purM, lysE and rluA.
Saman Hosseinkhani; Rose Szittner; Edward A Meighen
Random mutagenesis of bacterial luciferase: critical role of Glu175 in the control of luminescence decay.

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2007: Tom Defoirdt; Carol M Miyamoto; Thomas K Wood; Edward A Meighen; Patrick Sorgeloos; Willy Verstraete; Peter Bossier
The natural furanone (5Z)-4-bromo-5-(bromomethylene)-3-butyl-2(5H)-furanone disrupts quorum sensing-regulated gene expression in Vibrio harveyi by decreasing the DNA-binding activity of the transcriptional regulator protein luxR.
Environmental microbiology 2007;9(10):2486-95.
2006: Carol M Miyamoto; Edward A Meighen
Involvement of LuxR, a quorum sensing regulator in Vibrio harveyi, in the promotion of metabolic genes: argA, purM, lysE and rluA.
Biochimica et biophysica acta 2006;1759(6):296-307.
2005: Saman Hosseinkhani; Rose Szittner; Edward A Meighen
Random mutagenesis of bacterial luciferase: critical role of Glu175 in the control of luminescence decay.
The Biochemical journal 2005;385(Pt 2):575-80.
2004: Geun-Bae Kim; Carol M Miyamoto; Edward A Meighen; Byong H Lee
Cloning and characterization of the bile salt hydrolase genes (bsh) from Bifidobacterium bifidum strains.
Applied and environmental microbiology 2004;70(9):5603-12.
2004: Leo Yen-Cheng Lin; Rose Szittner; Romy Friedman; Edward A Meighen
Changes in the kinetics and emission spectrum on mutation of the chromophore-binding platform in Vibrio harveyi luciferase.
Biochemistry 2004;43(11):3183-94.
2003: Rose Szittner; Gregor Jansen; David Y Thomas; Edward A Meighen
Bright stable luminescent yeast using bacterial luciferase as a sensor.
Biochemical and biophysical research communications 2003;309(1):66-70.
2003: Carol M Miyamoto; Paul V Dunlap; Edward G Ruby; Edward A Meighen
LuxO controls luxR expression in Vibrio harveyi: evidence for a common regulatory mechanism in Vibrio.
Molecular microbiology 2003;48(2):537-48.
2002: Jaidip Chatterjee; Carol M Miyamoto; Athina Zouzoulas; B Franz Lang; Nicolas Skouris; Edward A Meighen
MetR and CRP bind to the Vibrio harveyi lux promoters and regulate luminescence.
Molecular microbiology 2002;46(1):101-11.
2002: Leo Yen-Cheng Lin; Traian Sulea; Rose Szittner; Christine Kor; Enrico O Purisima; Edward A Meighen
Implications of the reactive thiol and the proximal non-proline cis-peptide bond in the Structure and function of Vibrio harveyi luciferase.
Biochemistry 2002;41(31):9938-45.
2002: Pat M Fidopiastis; Carol M Miyamoto; Michael G Jobling; Edward A Meighen; Edward G Ruby
LitR, a new transcriptional activator in Vibrio fischeri, regulates luminescence and symbiotic light organ colonization.
Molecular microbiology 2002;45(1):131-43.
2002: Yi Hsing Lin; Carol M Miyamoto; Edward A Meighen
Cloning, sequencing, and functional studies of the rpoS gene from Vibrio harveyi.
Biochemical and biophysical research communications 2002;293(1):456-62.
2001: Leo Yen-Cheng Lin; Traian Sulea; Rose Szittner; V Vassilyev; Enrico O Purisima; Edward A Meighen
Modeling of the bacterial luciferase-flavin mononucleotide complex combining flexible docking with structure-activity data.
Protein science : a publication of the Protein Society 2001;10(8):1563-71.
2001: L Zhang; BC Ahvazi; Rose Szittner; Alice Vrielink; Edward A Meighen
Differences in nucleotide specificity and catalytic mechanism between Vibrio harveyi aldehyde dehydrogenase and other members of the aldehyde dehydrogenase superfamily.
Chemico-biological interactions 2001;130-132(1-3):29-38.
2000: Yi Hsing Lin; Carol M Miyamoto; Edward A Meighen
Cloning and functional studies of a luxO regulator LuxT from Vibrio harveyi.
Biochimica et biophysica acta 2000;1494(3):226-35.
2000: L Zhang; BC Ahvazi; Rose Szittner; Alice Vrielink; Edward A Meighen
A histidine residue in the catalytic mechanism distinguishes Vibrio harveyi aldehyde dehydrogenase from other members of the aldehyde dehydrogenase superfamily.
Biochemistry 2000;39(47):14409-18.
2000: Yi Hsing Lin; Carol M Miyamoto; Edward A Meighen
Purification and characterization of a luxO promoter binding protein LuxT from Vibrio harveyi.
Protein expression and purification 2000;20(1):87-94.
2000: J Li; Rose Szittner; Edward A Meighen
Hyperactivity and interactions of a chimeric myristoryl-ACP thioesterase from the lux system of luminescent bacteria.
Biochimica et biophysica acta 2000;1481(2):237-46.
2000: J Li; BC Ahvazi; Rose Szittner; Edward A Meighen
Mutation of the nucleophilic elbow of the Lux-specific thioesterase from Vibrio harveyi.
Biochemical and biophysical research communications 2000;275(2):704-8.
2000: BC Ahvazi; R Coulombe; M Delarge; M Vedadi; L Zhang; Edward A Meighen; Alice Vrielink
Crystal structure of the NADP+-dependent aldehyde dehydrogenase from Vibrio harveyi: structural implications for cofactor specificity and affinity.
The Biochemical journal 2000;349 Pt 3():853-61.
2000: Carol M Miyamoto; Yi Hsing Lin; Edward A Meighen
Control of bioluminescence in Vibrio fischeri by the LuxO signal response regulator.
Molecular microbiology 2000;36(3):594-607.
1999: N Valkova; Rose Szittner; Edward A Meighen
Control of luminescence decay and flavin binding by the LuxA carboxyl-terminal regions in chimeric bacterial luciferases.
Biochemistry 1999;38(42):13820-8.
1999: Z Li; N Valkova; Edward A Meighen
Spectral properties of Trp182, Trp194, and Trp250 on the alpha subunit of bacterial luciferase.
Biochemical and biophysical research communications 1999;263(3):820-4.
1999: L Zhang; BC Ahvazi; Rose Szittner; Alice Vrielink; Edward A Meighen
Change of nucleotide specificity and enhancement of catalytic efficiency in single point mutants of Vibrio harveyi aldehyde dehydrogenase.
Biochemistry 1999;38(35):11440-7.
1999: Edward A Meighen
Autoinduction of light emission in different species of bioluminescent bacteria.
Luminescence : the journal of biological and chemical luminescence 1999;14(1):3-9.
1998: J Li; Rose Szittner; Edward A Meighen
Tryptophan fluorescence of the lux-specific Vibrio harveyi acyl-ACP thioesterase and its tryptophan mutants: structural properties and ligand-induced conformational change.
Biochemistry 1998;37(46):16130-8.
1998: Carol M Miyamoto; W Sun; Edward A Meighen
The LuxR regulator protein controls synthesis of polyhydroxybutyrate in Vibrio harveyi.
Biochimica et biophysica acta 1998;1384(2):356-64.
1997: M Vedadi; Alice Vrielink; Edward A Meighen
Involvement of conserved glycine residues, 229 and 234, of Vibrio harveyi aldehyde dehydrogenase in activity and nucleotide binding.
Biochemical and biophysical research communications 1997;238(2):448-51.
1997: Gary B Dunphy; Carol M Miyamoto; Edward A Meighen
A homoserine lactone autoinducer regulates virulence of an insect-pathogenic bacterium, Xenorhabdus nematophilus (Enterobacteriaceae).
Journal of bacteriology 1997;179(17):5288-91.
1997: M Vedadi; Edward A Meighen
Critical glutamic acid residues affecting the mechanism and nucleotide specificity of Vibrio harveyi aldehyde dehydrogenase.
European journal of biochemistry / FEBS 1997;246(3):698-704.
1997: C Y Lee; Edward A Meighen
Cysteine-286 as the site of acylation of the Lux-specific fatty acyl-CoA reductase.
Biochimica et biophysica acta 1997;1338(2):215-22.
1997: M Vedadi; Nathalie Croteau; M Delarge; Alice Vrielink; Edward A Meighen
Structural and functional studies of a NADP(+)-specific aldehyde dehydrogenase from the luminescent marine bacterium Vibrio harveyi.
Advances in experimental medicine and biology 1997;414():269-75.
1996: Nathalie Croteau; M Vedadi; M Delarge; Edward A Meighen; M Abu-Abed; P Lynne Howell; Alice Vrielink
Crystallization and preliminary X-ray analysis of aldehyde dehydrogenase from Vibrio harveyi.
Protein science : a publication of the Protein Society 1996;5(10):2130-2.
1996: J Li; Rose Szittner; Zygmunt S Derewenda; Edward A Meighen
Conversion of serine-114 to cysteine-114 and the role of the active site nucleophile in acyl transfer by myristoyl-ACP thioesterase from Vibrio harveyi.
Biochemistry 1996;35(31):9967-73.
1996: J Chatterjee; C M Miyamoto; Edward A Meighen
Autoregulation of luxR: the Vibrio harveyi lux-operon activator functions as a repressor.
Molecular microbiology 1996;20(2):415-25.
1996: C M Miyamoto; J Chatterjee; E Swartzman; Rose Szittner; Edward A Meighen
The role of lux autoinducer in regulating luminescence in Vibrio harveyi; control of luxR expression.
Molecular microbiology 1996;19(4):767-75.
1995: M Vedadi; Rose Szittner; L Smillie; Edward A Meighen
Involvement of cysteine 289 in the catalytic activity of an NADP(+)-specific fatty aldehyde dehydrogenase from Vibrio harveyi.
Biochemistry 1995;34(51):16725-32.
1995: J G Cao; Z Y Wei; Edward A Meighen
The lux autoinducer-receptor interaction in Vibrio harveyi: binding parameters and structural requirements for the autoinducer.
The Biochemical journal 1995;312 ( Pt 2)():439-44.
1995: Z Li; Edward A Meighen
Tryptophan 250 on the alpha subunit plays an important role in flavin and aldehyde binding to bacterial luciferase. Effects of W-->Y mutations on catalytic function.
Biochemistry 1995;34(46):15084-90.
1994: C M Miyamoto; E E Smith; E Swartzman; J G Cao; A F Graham; Edward A Meighen
Proximal and distal sites bind LuxR independently and activate expression of the Vibrio harveyi lux operon.
Molecular microbiology 1994;14(2):255-62.
1994: D M Lawson; Urszula Derewenda; L Serre; S Ferri; Rose Szittner; Y Wei; Edward A Meighen; Zygmunt S Derewenda
Structure of a myristoyl-ACP-specific thioesterase from Vibrio harveyi.
Biochemistry 1994;33(32):9382-8.
1994: W Sun; J G Cao; K Teng; Edward A Meighen
Biosynthesis of poly-3-hydroxybutyrate in the luminescent bacterium, Vibrio harveyi, and regulation by the lux autoinducer, N-(3-hydroxybutanoyl)homoserine lactone.
The Journal of biological chemistry 1994;269(32):20785-90.
1994: C Y Lee; D J O'Kane; Edward A Meighen
Riboflavin synthesis genes are linked with the lux operon of Photobacterium phosphoreum.
Journal of bacteriology 1994;176(7):2100-4.
1994: S R Ferri; Edward A Meighen
An essential histidine residue required for fatty acylation and acyl transfer by myristoyltransferase from luminescent bacteria.
The Journal of biological chemistry 1994;269(9):6683-8.
1994: Z Li; Edward A Meighen
The turnover of bacterial luciferase is limited by a slow decomposition of the ternary enzyme-product complex of luciferase, FMN, and fatty acid.
The Journal of biological chemistry 1994;269(9):6640-4.
1994: Edward A Meighen
Genetics of bacterial bioluminescence.
Annual review of genetics 1994;28():117-39.
1993: Z Li; Rose Szittner; Edward A Meighen
Subunit interactions and the role of the luxA polypeptide in controlling thermal stability and catalytic properties in recombinant luciferase hybrids.
Biochimica et biophysica acta 1993;1158(2):137-45.
1993: E Swartzman; Edward A Meighen
Purification and characterization of a poly(dA-dT) lux-specific DNA-binding protein from Vibrio harveyi and identification as LuxR.
The Journal of biological chemistry 1993;268(22):16706-16.
1993: Edward A Meighen
Bacterial bioluminescence: organization, regulation, and application of the lux genes.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1993;7(11):1016-22.
1993: C Y Lee; Rose Szittner; C M Miyamoto; Edward A Meighen
The gene convergent to luxG in Vibrio fischeri codes for a protein related in sequence to RibG and deoxycytidylate deaminase.
Biochimica et biophysica acta 1993;1143(3):337-9.
1993: J G Cao; Edward A Meighen
Biosynthesis and stereochemistry of the autoinducer controlling luminescence in Vibrio harveyi.
Journal of bacteriology 1993;175(12):3856-62.
1993: Edward A Meighen; P V Dunlap
Physiological, biochemical and genetic control of bacterial bioluminescence.
Advances in microbial physiology 1993;34():1-67.
1992: E Swartzman; M Silverman; Edward A Meighen
The luxR gene product of Vibrio harveyi is a transcriptional activator of the lux promoter.
Journal of bacteriology 1992;174(22):7490-3.
1992: Z Li; Edward A Meighen
Fatty acid-enhanced binding of flavin mononucleotide to bacterial luciferase measured by steady-state fluorescence.
Biochemical and biophysical research communications 1992;188(2):497-502.
1992: L Swenson; S R Ferri; R Green; A M Sharp; Edward A Meighen; Zygmunt S Derewenda
Expression, purification and crystallization of the Vibrio harveyi acyltransferase.
Journal of molecular biology 1992;227(2):572-4.
1992: Edward A Meighen; Rose Szittner
Multiple repetitive elements and organization of the lux operons of luminescent terrestrial bacteria.
Journal of bacteriology 1992;174(16):5371-81.
1992: E Swartzman; Edward A Meighen
Vibrio harveyi RNA polymerase: purification and resolution from gyrase A.
Biochemistry and cell biology = Biochimie et biologie cellulaire 1992;70(8):698-702.
1992: C Y Lee; Edward A Meighen
The lux genes in Photobacterium leiognathi are closely linked with genes corresponding in sequence to riboflavin synthesis genes.
Biochemical and biophysical research communications 1992;186(2):690-7.
1991: C Y Lee; Rose Szittner; Edward A Meighen
The lux genes of the luminous bacterial symbiont, Photobacterium leiognathi, of the ponyfish. Nucleotide sequence, difference in gene organization, and high expression in mutant Escherichia coli.
European journal of biochemistry / FEBS 1991;201(1):161-7.
1991: S R Ferri; Edward A Meighen
A lux-specific myristoyl transferase in luminescent bacteria related to eukaryotic serine esterases.
The Journal of biological chemistry 1991;266(20):12852-7.
1991: R R Soly; Edward A Meighen
Identification of the acyl transfer site of fatty acyl-protein synthetase from bioluminescent bacteria.
Journal of molecular biology 1991;219(1):69-77.
1991: S R Ferri; R R Soly; Rose Szittner; Edward A Meighen
Structure and properties of luciferase from Photobacterium phosphoreum.
Biochemical and biophysical research communications 1991;176(1):541-8.
1991: Edward A Meighen
Molecular biology of bacterial bioluminescence.
Microbiological reviews 1991;55(1):123-42.
1990: A Swartzman; S Kapoor; A F Graham; Edward A Meighen
A new Vibrio fischeri lux gene precedes a bidirectional termination site for the lux operon.
Journal of bacteriology 1990;172(12):6797-802.
1990: Rose Szittner; Edward A Meighen
Nucleotide sequence, expression, and properties of luciferase coded by lux genes from a terrestrial bacterium.
The Journal of biological chemistry 1990;265(27):16581-7.
1990: C M Miyamoto; Edward A Meighen; A F Graham
Transcriptional regulation of lux genes transferred into Vibrio harveyi.
Journal of bacteriology 1990;172(4):2046-54.
1990: E Swartzman; C Miyamoto; A Graham; Edward A Meighen
Delineation of the transcriptional boundaries of the lux operon of Vibrio harveyi demonstrates the presence of two new lux genes.
The Journal of biological chemistry 1990;265(6):3513-7.
1989: J G Cao; Edward A Meighen
Purification and structural identification of an autoinducer for the luminescence system of Vibrio harveyi.
The Journal of biological chemistry 1989;264(36):21670-6.
1989: M O Boylan; Jerry Pelletier; S Dhepagnon; S Trudel; N Sonenberg; Edward A Meighen
Construction of a fused LuxAB gene by site-directed mutagenesis.
Journal of bioluminescence and chemiluminescence 1989;4(1):310-6.
1989: M Boylan; C Miyamoto; L Wall; A Graham; Edward A Meighen
Lux C, D and E genes of the Vibrio fischeri luminescence operon code for the reductase, transferase, and synthetase enzymes involved in aldehyde biosynthesis.
Photochemistry and photobiology 1989;49(5):681-8.
1989: M Boylan; Jerry Pelletier; Edward A Meighen
Fused bacterial luciferase subunits catalyze light emission in eukaryotes and prokaryotes.
The Journal of biological chemistry 1989;264(4):1915-8.
1989: L Wall; Edward A Meighen
Covalent reaction of cerulenin at the active site of acyl-CoA reductase of Photobacterium phosphoreum.
Biochemistry and cell biology = Biochimie et biologie cellulaire 1989;67(2-3):163-7.
1988: J A Mancini; M Boylan; R R Soly; A F Graham; Edward A Meighen
Cloning and expression of the Photobacterium phosphoreum luminescence system demonstrates a unique lux gene organization.
The Journal of biological chemistry 1988;263(28):14308-14.
1988: C M Miyamoto; M Boylan; A F Graham; Edward A Meighen
Organization of the lux structural genes of Vibrio harveyi. Expression under the T7 bacteriophage promoter, mRNA analysis, and nucleotide sequence of the luxD gene.
The Journal of biological chemistry 1988;263(26):13393-9.
1988: R R Soly; J A Mancini; S R Ferri; M Boylan; Edward A Meighen
A new lux gene in bioluminescent bacteria codes for a protein homologous to the bacterial luciferase subunits.
Biochemical and biophysical research communications 1988;155(1):351-8.
1988: C M Miyamoto; A F Graham; Edward A Meighen
Nucleotide sequence of the LuxC gene and the upstream DNA from the bioluminescent system of Vibrio harveyi.
Nucleic acids research 1988;16(4):1551-62.
1988: D M Byers; A Bognar; Edward A Meighen
Differential regulation of enzyme activities involved in aldehyde metabolism in the luminescent bacterium Vibrio harveyi.
Journal of bacteriology 1988;170(2):967-71.
1987: C Miyamoto; D Byers; A F Graham; Edward A Meighen
Expression of bioluminescence by Escherichia coli containing recombinant Vibrio harveyi DNA.
Journal of bacteriology 1987;169(1):247-53.
1986: L Wall; A Rodriguez; Edward A Meighen
Intersubunit transfer of fatty acyl groups during fatty acid reduction.
The Journal of biological chemistry 1986;261(34):15981-8.
1985: D M Byers; Edward A Meighen
Acyl-acyl carrier protein as a source of fatty acids for bacterial bioluminescence.
Proceedings of the National Academy of Sciences of the United States of America 1985;82(18):6085-9.
1985: M Boylan; A F Graham; Edward A Meighen
Functional identification of the fatty acid reductase components encoded in the luminescence operon of Vibrio fischeri.
Journal of bacteriology 1985;163(3):1186-90.
1985: C M Miyamoto; A D Graham; M Boylan; J F Evans; Chuck Hasel; Edward A Meighen; A F Graham
Polycistronic mRNAs code for polypeptides of the Vibrio harveyi luminescence system.
Journal of bacteriology 1985;161(3):995-1001.
1984: L Wall; A Rodriquez; Edward A Meighen
Differential acylation in vitro with tetradecanoyl coenzyme A and tetradecanoic acid (+ATP) of three polypeptides shown to have induced synthesis in Photobacterium phosphoreum.
The Journal of biological chemistry 1984;259(3):1409-14.
1983: Edward A Meighen; Rose Szittner; G G Grant
Determination of the release rate of aldehyde pheromones from insect lures by cold trapping and direct bioluminescence analysis.
Analytical biochemistry 1983;133(1):179-85.
1983: J F Evans; S McCracken; C M Miyamoto; Edward A Meighen; A F Graham
In vitro synthesis of subunits of bacterial luciferase in an Escherichia coli system.
Journal of bacteriology 1983;153(1):543-5.