Dirk Meijer

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Prakash Jai; de Borst Martin H; Lacombe Marie; Opdam Frank; Klok Pieter A; van Goor Harry; Meijer Dirk K F; Moolenaar Frits; Poelstra Klaas; Kok Robbert J
Inhibition of renal rho kinase attenuates ischemia/reperfusion-induced injury.
Prakash Jai; de Borst Martin H; van Loenen-Weemaes Annemiek M; Lacombe Marie; Opdam Frank; van Goor Harry; Meijer Dirk K F; Moolenaar Frits; Poelstra Klaas; Kok Robbert J
Cell-specific delivery of a transforming growth factor-beta type I receptor kinase inhibitor to proximal tubular cells for the treatment of renal fibrosis.
van de Bovenkamp M; Groothuis G M M; Meijer D K F; Olinga P
Liver slices as a model to study fibrogenesis and test the effects of anti-fibrotic drugs on fibrogenic cells in human liver.

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2008: Prakash Jai; de Borst Martin H; Lacombe Marie; Opdam Frank; Klok Pieter A; van Goor Harry; Meijer Dirk K F; Moolenaar Frits; Poelstra Klaas; Kok Robbert J
Inhibition of renal rho kinase attenuates ischemia/reperfusion-induced injury.
Journal of the American Society of Nephrology : JASN 2008;19(11):2086-97.
2008: Prakash Jai; de Borst Martin H; van Loenen-Weemaes Annemiek M; Lacombe Marie; Opdam Frank; van Goor Harry; Meijer Dirk K F; Moolenaar Frits; Poelstra Klaas; Kok Robbert J
Cell-specific delivery of a transforming growth factor-beta type I receptor kinase inhibitor to proximal tubular cells for the treatment of renal fibrosis.
Pharmaceutical research 2008;25(10):2427-39.
2008: van de Bovenkamp M; Groothuis G M M; Meijer D K F; Olinga P
Liver slices as a model to study fibrogenesis and test the effects of anti-fibrotic drugs on fibrogenic cells in human liver.
Toxicology in vitro : an international journal published in association with BIBRA 2008;22(3):771-8.
2007: Weeke-Klimp Alida H; Bartsch Martin; Morselt Henriëtte W M; Van Veen-Hof Ingrid; Meijer Dirk K F; Scherphof Gerrit L; Kamps Jan A A M
Targeting of stabilized plasmid lipid particles to hepatocytes in vivo by means of coupled lactoferrin.
Journal of drug targeting 2007;15(9):585-94.
2007: Adrian Joanna E; Kamps Jan A A M; Scherphof Gerrit L; Meijer Dirk K F; van Loenen-Weemaes Anne-miek; Reker-Smit Catharina; Terpstra Peter; Poelstra Klaas
A novel lipid-based drug carrier targeted to the non-parenchymal cells, including hepatic stellate cells, in the fibrotic livers of bile duct ligated rats.
Biochimica et biophysica acta 2007;1768(6):1430-9.
2007: Gonzalo Teresa; Beljaars Leonie; van de Bovenkamp Marja; Temming Kai; van Loenen Anne-Miek; Reker-Smit Catharina; Meijer Dirk K F; Lacombe Marie; Opdam Frank; Kéri György; Orfi László; Poelstra Klaas; Kok Robbert J
Local inhibition of liver fibrosis by specific delivery of a platelet-derived growth factor kinase inhibitor to hepatic stellate cells.
The Journal of pharmacology and experimental therapeutics 2007;321(3):856-65.
2007: Van de Bovenkamp M; Groothuis G M M; Meijer D K F; Olinga P
Liver fibrosis in vitro: cell culture models and precision-cut liver slices.
Toxicology in vitro : an international journal published in association with BIBRA 2007;21(4):545-57.
2007: Adrian Joanna E; Poelstra Klaas; Scherphof Gerrit L; Meijer Dirk K F; van Loenen-Weemaes Anne-miek; Reker-Smit Catharina; Morselt Henriëtte W M; Zwiers Peter; Kamps Jan A A M
Effects of a new bioactive lipid-based drug carrier on cultured hepatic stellate cells and liver fibrosis in bile duct-ligated rats.
The Journal of pharmacology and experimental therapeutics 2007;321(2):536-43.
2007: Adrian Joanna E; Kamps Jan A A M; Poelstra Klaas; Scherphof Gerrit L; Meijer Dirk K F; Kaneda Yasufumi
Delivery of viral vectors to hepatic stellate cells in fibrotic livers using HVJ envelopes fused with targeted liposomes.
Journal of drug targeting 2007;15(1):75-82.
2007: Vermeulen Joost N; Meijer Dirk K F; Over Jan; Lange Joep; Proost Johannes H; Bakker Hester I; Beljaars Leonie; Wit Ferdinand W N M; Prins Jan M
A phase I/IIa study with succinylated human serum albumin (Suc-HSA), a candidate HIV-1 fusion inhibitor.
Antiviral therapy 2007;12(2):273-8.
2006: van de Bovenkamp Marja; Groothuis Geny M M; Meijer Dirk K F; Olinga Peter
Precision-cut fibrotic rat liver slices as a new model to test the effects of anti-fibrotic drugs in vitro.
Journal of hepatology 2006;45(5):696-703.
2006: Prakash Jai; Sandovici Maria; Saluja Vinay; Lacombe Marie; Schaapveld Roel Q J; de Borst Martin H; van Goor Harry; Henning Robert H; Proost Johannes H; Moolenaar Frits; Këri György; Meijer Dirk K F; Poelstra Klaas; Kok Robbert J
Intracellular delivery of the p38 mitogen-activated protein kinase inhibitor SB202190 [4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)1H-imidazole] in renal tubular cells: a novel strategy to treat renal fibrosis.
The Journal of pharmacology and experimental therapeutics 2006;319(1):8-19.
2006: van de Bovenkamp M; Groothuis G M M; Meijer D K F; Slooff M J H; Olinga P
Human liver slices as an in vitro model to study toxicity-induced hepatic stellate cell activation in a multicellular milieu.
Chemico-biological interactions 2006;162(1):62-9.
2006: Greupink Rick; Bakker Hester I; Bouma Wilma; Reker-Smit Catharina; Meijer Dirk K F; Beljaars Leonie; Poelstra Klaas
The antiproliferative drug doxorubicin inhibits liver fibrosis in bile duct-ligated rats and can be selectively delivered to hepatic stellate cells in vivo.
The Journal of pharmacology and experimental therapeutics 2006;317(2):514-21.
2006: Gonzalo Teresa; Talman Eduard G; van de Ven Anke; Temming Kai; Greupink Rick; Beljaars Leonie; Reker-Smit Catharina; Meijer Dirk K F; Molema Grietje; Poelstra Klaas; Kok Robbert J
Selective targeting of pentoxifylline to hepatic stellate cells using a novel platinum-based linker technology.
Journal of controlled release : official journal of the Controlled Release Society 2006;111(1-2):193-203.
2006: Hagens Werner I; Olinga Peter; Meijer Dirk K F; Groothuis Geny M M; Beljaars Leonie; Poelstra Klaas
Gliotoxin non-selectively induces apoptosis in fibrotic and normal livers.
Liver international : official journal of the International Association for the Study of the Liver 2006;26(2):232-9.
2006: Adrian Joanna E; Poelstra Klaas; Scherphof Gerrit L; Molema Grietje; Meijer Dirk K F; Reker-Smit Catharina; Morselt Henriëtte W M; Kamps Jan A A M
Interaction of targeted liposomes with primary cultured hepatic stellate cells: Involvement of multiple receptor systems.
Journal of hepatology 2006;44(3):560-7.
2006: Tuin Annemarie; Huizinga-Van der Vlag Ali; van Loenen-Weemaes Anne-Miek M A; Meijer Dirk K F; Poelstra Klaas
On the role and fate of LPS-dephosphorylating activity in the rat liver.
American journal of physiology. Gastrointestinal and liver physiology 2006;290(2):G377-85.
2006: Proost Johannes H; Beljaars Leonie; Olinga Peter; Swart Pieter J; Kuipers Mirjam E; Reker-Smit Catharina; Groothuis Geny M M; Meijer Dirk K F
Prediction of the pharmacokinetics of succinylated human serum albumin in man from in vivo disposition data in animals and in vitro liver slice incubations.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2006;27(2-3):123-32.
2005: Prakash Jai; Saluja Vinay; Visser Jan; Moolenaar Frits; Meijer Dirk K F; Poelstra Klaas; Kok Robbert J
Bioanalysis and pharmacokinetics of the p38 MAPkinase inhibitor SB202190 in rats.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2005;826(1-2):220-5.
2005: Greupink Rick; Bakker Hester I; Reker-Smit Catharina; van Loenen-Weemaes Anne-miek; Kok Robbert-Jan; Meijer Dirk K F; Beljaars Leonie; Poelstra Klaas
Studies on the targeted delivery of the antifibrogenic compound mycophenolic acid to the hepatic stellate cell.
Journal of hepatology 2005;43(5):884-92.
2005: van de Kerkhof Esther G; de Graaf Inge A M; de Jager Marina H; Meijer Dirk K F; Groothuis Geny M M
Characterization of rat small intestinal and colon precision-cut slices as an in vitro system for drug metabolism and induction studies.
Drug metabolism and disposition: the biological fate of chemicals 2005;33(11):1613-20.
2005: Meijer Dirk K F; Lennernäs Hans
EUFEPS conference on drug transporters at Copenhagen: integrative approaches in ADME research.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2005;26(1):130-43.
2005: van de Bovenkamp Marja; Groothuis Geny M M; Draaisma Annelies L; Merema Marjolijn T; Bezuijen Judith I; van Gils Marit J; Meijer Dirk K F; Friedman Scott L; Olinga Peter
Precision-cut liver slices as a new model to study toxicity-induced hepatic stellate cell activation in a physiologic milieu.
Toxicological sciences : an official journal of the Society of Toxicology 2005;85(1):632-8.
2005: Prakash Jai; van Loenen-Weemaes Annemiek M; Haas Marijke; Proost Johannes H; Meijer Dirk K F; Moolenaar Frits; Poelstra Klaas; Kok Robbert J
Renal-selective delivery and angiotensin-converting enzyme inhibition by subcutaneously administered captopril-lysozyme.
Drug metabolism and disposition: the biological fate of chemicals 2005;33(5):683-8.
2005: Waarts Barry-Lee; Aneke Onwuchekwa J C; Smit Jolanda M; Kimata Koji; Bittman Robert; Meijer Dirk K F; Wilschut Jan
Antiviral activity of human lactoferrin: inhibition of alphavirus interaction with heparan sulfate.
Virology 2005;333(2):284-92.
2005: Bartsch Martin; Weeke-Klimp Alida H; Morselt Henriëtte W M; Kimpfler Andrea; Asgeirsdóttir Sigridur A; Schubert Rolf; Meijer Dirk K F; Scherphof Gerrit L; Kamps Jan A A M
Optimized targeting of polyethylene glycol-stabilized anti-intercellular adhesion molecule 1 oligonucleotide/lipid particles to liver sinusoidal endothelial cells.
Molecular pharmacology 2005;67(3):883-90.
2005: Prakash J; Kok R J; van Loenen-Weemaes A; Haas M; Proost J H; Meijer D K F; Moolenaar F
Renal targeting of captopril using subcutaneous administration of captopril-lysozyme conjugate.
Journal of controlled release : official journal of the Controlled Release Society 2005;101(1-3):350-1.
2005: de Kanter Ruben; Tuin Annemarie; van de Kerkhof Esther; Martignoni Marcella; Draaisma Annelies L; de Jager Marina H; de Graaf Inge A M; Meijer Dirk K F; Groothuis Geny M M
A new technique for preparing precision-cut slices from small intestine and colon for drug biotransformation studies.
Journal of pharmacological and toxicological methods 2005;51(1):65-72.
2005: Bartsch Martin; Weeke-Klimp Alida H; Meijer Dirk K F; Scherphof Gerrit L; Kamps Jan A A M
Cell-specific targeting of lipid-based carriers for ODN and DNA.
Journal of liposome research 2005;15(1-2):59-92.
2004: Rachmawati Heni; Beljaars Leonie; Reker-Smit Catharina; Van Loenen-Weemaes Anne-miek M; Hagens Werner I; Meijer Dirk K F; Poelstra Klaas
Pharmacokinetic and biodistribution profile of recombinant human interleukin-10 following intravenous administration in rats with extensive liver fibrosis.
Pharmaceutical research 2004;21(11):2072-8.
2004: Schraa Astrid J; Kok Robbert J; Botter Sander M; Withoff Sebo; Meijer Dirk K F; de Leij Lou F M H; Molema Grietje
RGD-modified anti-CD3 antibodies redirect cytolytic capacity of cytotoxic T lymphocytes toward alphavbeta3-expressing endothelial cells.
International journal of cancer. Journal international du cancer 2004;112(2):279-85.
2004: Elferink Marieke G L; Olinga Peter; Draaisma Annelies L; Merema Marjolijn T; Faber Klaas Nico; Slooff Maarten J H; Meijer Dirk K F; Groothuis Geny M M
LPS-induced downregulation of MRP2 and BSEP in human liver is due to a posttranscriptional process.
American journal of physiology. Gastrointestinal and liver physiology 2004;287(5):G1008-16.
2004: Beljaars Leonie; van der Strate Barry W A; Bakker Hester I; Reker-Smit Catharina; van Loenen-Weemaes Anne-Miek; Wiegmans Frouwke C; Harmsen Martin C; Molema Grietje; Meijer Dirk K F
Inhibition of cytomegalovirus infection by lactoferrin in vitro and in vivo.
Antiviral research 2004;63(3):197-208.
2004: Verweij Willem Ronald; Bentala Hafida; Huizinga-van der Vlag Ali; Miek van Loenen-Weemaes Anne; Kooi Kor; Meijer Dirk Klaas Fokke; Poelstra Klaas
Protection against an Escherichia coli-induced sepsis by alkaline phosphatase in mice.
Shock (Augusta, Ga.) 2004;22(2):174-9.
2004: Ogawara Ken-ichi; Rots Marianne G; Kok Robbert J; Moorlag Henk E; Van Loenen Anne-Miek; Meijer Dirk K F; Haisma Hidde J; Molema Grietje
A novel strategy to modify adenovirus tropism and enhance transgene delivery to activated vascular endothelial cells in vitro and in vivo.
Human gene therapy 2004;15(5):433-43.
2004: De Kanter R; Monshouwer M; Draaisma A L; De Jager M H; de Graaf I A M; Proost J H; Meijer D K F; Groothuis G M M
Prediction of whole-body metabolic clearance of drugs through the combined use of slices from rat liver, lung, kidney, small intestine and colon.
Xenobiotica; the fate of foreign compounds in biological systems 2004;34(3):229-41.
2004: Bartsch Martin; Weeke-Klimp Alida H; Hoenselaar Evelien P D; Stuart Marc C A; Meijer Dirk K F; Scherphof Gerrit L; Kamps Jan A A M
Stabilized lipid coated lipoplexes for the delivery of antisense oligonucleotides to liver endothelial cells in vitro and in vivo.
Journal of drug targeting 2004;12(9-10):613-21.
2003: van der Strate B W A; Hillebrands J L; Lycklama à Nijeholt S S; Beljaars L; Bruggeman C A; Van Luyn M J A; Rozing J; The T H; Meijer D K F; Molema G; Harmsen M C
Dissemination of rat cytomegalovirus through infected granulocytes and monocytes in vitro and in vivo.
Journal of virology 2003;77(20):11274-8.
2003: Beljaars Leonie; Weert Betty; Geerts Albert; Meijer Dirk K F; Poelstra Klaas
The preferential homing of a platelet derived growth factor receptor-recognizing macromolecule to fibroblast-like cells in fibrotic tissue.
Biochemical pharmacology 2003;66(7):1307-17.
2003: Haas Marijke; de Boer Eric; de Jong Paul E; Moolenaar Frits; Meijer Dirk K F; de Zeeuw Dick
Effects of anti-proteinuric therapy with angiotensin-converting-enzyme inhibition on renal protein catabolism in the adriamycin-induced nephrotic rat.
Clinical science (London, England : 1979) 2003;105(1):51-7.
2003: van Montfoort J E; Hagenbuch B; Groothuis G M M; Koepsell H; Meier P J; Meijer D K F
Drug uptake systems in liver and kidney.
Current drug metabolism 2003;4(3):185-211.
2003: Asgeirsdóttir Sigridur A; Kok Robbert J; Everts Maaike; Meijer Dirk K F; Molema Grietje
Delivery of pharmacologically active dexamethasone into activated endothelial cells by dexamethasone-anti-E-selectin immunoconjugate.
Biochemical pharmacology 2003;65(10):1729-39.
2003: van der Strate Barry W A; De Boer Froukje M; Bakker Hester I; Meijer Dirk K F; Molema Grietje; Harmsen Martin C
Synergy of bovine lactoferrin with the anti-cytomegalovirus drug cidofovir in vitro.
Antiviral research 2003;58(2):159-65.
2003: Haverdings R G F; Haas M; Navis G J; van Loenen-Weemaes A M A; Meijer D K F; de Zeeuw D; Moolenaar F
Renal targeting of captopril selectively enhances the intrarenal over the systemic effects of ACE inhibition in rats.
British journal of pharmacology 2003;138(4):531.
2003: Melgert Barbro N; Weert Betty; Schellekens Huub; Meijer Dirk K F; Poelstra Klaas
The pharmacokinetic and biological activity profile of dexamethasone targeted to sinusoidal endothelial and Kupffer cells.
Journal of drug targeting 2003;11(1):1-10.
2003: Everts Maaike; Koning Gerben A; Kok Robbert J; Asgeirsdóttir Sigridur A; Vestweber Dietmar; Meijer Dirk K F; Storm Gert; Molema Grietje
In vitro cellular handling and in vivo targeting of E-selectin-directed immunoconjugates and immunoliposomes used for drug delivery to inflamed endothelium.
Pharmaceutical research 2003;20(1):64-72.
2002: Haas Marijke; Moolenaar Frits; Meijer Dirk K F; de Zeeuw Dick
Specific drug delivery to the kidney.
Cardiovascular drugs and therapy / sponsored by the International Society of Cardiovascular Pharmacotherapy 2002;16(6):489-96.
2002: Bentala Hafida; Verweij Willem R; Huizinga-Van der Vlag Ali; van Loenen-Weemaes Annemiek M; Meijer Dirk K F; Poelstra Klaas
Removal of phosphate from lipid A as a strategy to detoxify lipopolysaccharide.
Shock (Augusta, Ga.) 2002;18(6):561-6.
2002: Schraa Astrid J; Kok Robbert J; Moorlag Henk E; Bos Erwin J; Proost Johannes H; Meijer Dirk K F; de Leij Lou F M H; Molema Grietje
Targeting of RGD-modified proteins to tumor vasculature: a pharmacokinetic and cellular distribution study.
International journal of cancer. Journal international du cancer 2002;102(5):469-75.
2002: Kok Robbert J; Everts Maaike; Asgeirsdóttir Sigridur A; Meijer Dirk K F; Molema Grietje
Cellular handling of a dexamethasone-anti-E-selectin immunoconjugate by activated endothelial cells: comparison with free dexamethasone.
Pharmaceutical research 2002;19(11):1730-5.
2002: Schraa Astrid J; Kok Robbert J; Berendsen Agnes D; Moorlag Henk E; Bos Erwin J; Meijer Dirk K F; de Leij Lou F M H; Molema Grietje
Endothelial cells internalize and degrade RGD-modified proteins developed for tumor vasculature targeting.
Journal of controlled release : official journal of the Controlled Release Society 2002;83(2):241-51.
2002: Meijer Dirk K F; van Monffoort Jessica E
Interactions of cationic drugs and cardiac glycosides at the hepatic uptake level: studies in the rat in vivo, isolated perfused rat liver, isolated rat hepatocytes and oocytes expressing oatp2.
Archives of pharmacal research 2002;25(4):397-415.
2002: Haverdings R Folgert G; Haas Marijke; Navis Gerjan; Van Loenen-Weemaes Anne-Miek; Meijer Dirk K F; De Zeeuw Dick; Moolenaar Frits
Renal targeting of captopril selectively enhances the intrarenal over the systemic effects of ACE inhibition in rats.
British journal of pharmacology 2002;136(8):1107-16.
2002: Berkhout Ben; van Wamel Jeroen L B; Beljaars Leonie; Meijer Dirk K F; Visser Servaas; Floris René
Characterization of the anti-HIV effects of native lactoferrin and other milk proteins and protein-derived peptides.
Antiviral research 2002;55(2):341-55.
2002: Kok R J; Haverdings R F G; Grijpstra F; Koiter J; Moolenaar F; de Zeeuw D; Meijer D K F
Targeting of captopril to the kidney reduces renal angiotensin-converting enzyme activity without affecting systemic blood pressure.
The Journal of pharmacology and experimental therapeutics 2002;301(3):1139-43.
2002: Bartsch Martin; Weeke-Klimp Alida H; Meijer Dirk K F; Scherphof Gerrit L; Kamps Jan A A M
Massive and selective delivery of lipid-coated cationic lipoplexes of oligonucleotides targeted in vivo to hepatic endothelial cells.
Pharmaceutical research 2002;19(5):676-80.
2002: De Kanter R; De Jager M H; Draaisma A L; Jurva J U; Olinga P; Meijer D K F; Groothuis G M M
Drug-metabolizing activity of human and rat liver, lung, kidney and intestine slices.
Xenobiotica; the fate of foreign compounds in biological systems 2002;32(5):349-62.
2002: Beljaars Leonie; Floris René; Berkhout Ben; Smit Catharina; Meijer Dirk K F; Molema Grietje
The influence of charge clustering on the anti-HIV-1 activity and in vivo distribution of negatively charged albumins.
Biochemical pharmacology 2002;63(9):1663-73.
2002: Beljaars Leonie; Meijer Dirk K F; Poelstra Klaas
Targeting hepatic stellate cells for cell-specific treatment of liver fibrosis.
Frontiers in bioscience : a journal and virtual library 2002;7():e214-22.
2002: Kuipers M E; Beljaars L; Van Beek N; De Vries H G; Heegsma J; Van Den Berg J J M; Meijer D K F; Swart P J
Conditions influencing the in vitro antifungal activity of lactoferrin combined with antimycotics against clinical isolates of Candida. Impact on the development of buccal preparations of lactoferrin.
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica 2002;110(4):290-8.
2002: Hooiveld Guido J E J; Heegsma Janette; van Montfoort Jessica E; Jansen Peter L M; Meijer Dirk K F; Müller Michael
Stereoselective transport of hydrophilic quaternary drugs by human MDR1 and rat Mdr1b P-glycoproteins.
British journal of pharmacology 2002;135(7):1685-94.
2002: Haas Marijke; Moolenaar Frits; Elsinga Angela; Van der Wouden Els A; de Jong Paul E; Meijer Dirk K F; de Zeeuw Dick
Targeting of doxorubicin to the urinary bladder of the rat shows increased cytotoxicity in the bladder urine combined with an absence of renal toxicity.
Journal of drug targeting 2002;10(1):81-9.
2002: de Kanter R; Monshouwer M; Meijer D K F; Groothuis G M M
Precision-cut organ slices as a tool to study toxicity and metabolism of xenobiotics with special reference to non-hepatic tissues.
Current drug metabolism 2002;3(1):39-59.
2002: Beljaars Leonie; Bakker Hester I; van der Strate Barry W A; Smit Catharina; Duijvestijn Adrian M; Meijer Dirk K F; Molema Grietje
The antiviral protein human lactoferrin is distributed in the body to cytomegalovirus (CMV) infection-prone cells and tissues.
Pharmaceutical research 2002;19(1):54-62.
2002: Kuipers Mirjam E; Heegsma Jannet; Bakker Hester I; Meijer Dick K F; Swart Pieter J; Frijlink Erik W; Eissens Anco C; de Vries-Hospers Hilly G; van den Berg Jeroen J M
Design and fungicidal activity of mucoadhesive lactoferrin tablets for the treatment of oropharyngeal candidosis.
Drug delivery 2002;9(1):31-8.
2002: Kok Robbert J; Schraa Astrid J; Bos Erwin J; Moorlag Henk E; Asgeirsdóttir Sigridur A; Everts Maaike; Meijer Dirk K F; Molema Grietje
Preparation and functional evaluation of RGD-modified proteins as alpha(v)beta(3) integrin directed therapeutics.
Bioconjugate chemistry 2002;13(1):128-35.
2002: Everts Maaike; Kok Robbert J; Asgeirsdóttir Sigridur A; Melgert Barbro N; Moolenaar Tom J M; Koning Gerben A; van Luyn Marja J A; Meijer Dirk K F; Molema Grietje
Selective intracellular delivery of dexamethasone into activated endothelial cells using an E-selectin-directed immunoconjugate.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(2):883-9.
2002: Schraa Astrid J; Everts Maaike; Kok Robbert J; Asgeirsdóttir Sigridur A; Meijer Dirk K F; de Leij Lou F M H; Molema Grietje
Development of vasculature targeting strategies for the treatment of cancer and chronic inflammatory diseases.
Biotechnology annual review 2002;8():133-65.
2001: van der Strate B W; Beljaars L; Molema G; Harmsen M C; Meijer D K
Antiviral activities of lactoferrin.
Antiviral research 2001;52(3):225-39.
2001: Cattori V; van Montfoort J E; Stieger B; Landmann L; Meijer D K; Winterhalter K H; Meier P J; Hagenbuch B
Localization of organic anion transporting polypeptide 4 (Oatp4) in rat liver and comparison of its substrate specificity with Oatp1, Oatp2 and Oatp3.
Pflügers Archiv : European journal of physiology 2001;443(2):188-95.
2001: Beljaars L; Olinga P; Molema G; de Bleser P; Geerts A; Groothuis G M; Meijer D K; Poelstra K
Characteristics of the hepatic stellate cell-selective carrier mannose 6-phosphate modified albumin (M6P(28)-HSA).
Liver 2001;21(5):320-8.
2001: Melgert B N; Olinga P; Van Der Laan J M; Weert B; Cho J; Schuppan D; Groothuis G M; Meijer D K; Poelstra K
Targeting dexamethasone to Kupffer cells: effects on liver inflammation and fibrosis in rats.
Hepatology (Baltimore, Md.) 2001;34(4 Pt 1):719-28.
2001: Olinga P; Merema M T; de Jager M H; Derks F; Melgert B N; Moshage H; Slooff M J; Meijer D K; Poelstra K; Groothuis G M
Rat liver slices as a tool to study LPS-induced inflammatory response in the liver.
Journal of hepatology 2001;35(2):187-94.
2001: van der Strate B W; Harmsen M C; Schäfer P; Swart P J; The T H; Jahn G; Speer C P; Meijer D K; Hamprecht K
Viral load in breast milk correlates with transmission of human cytomegalovirus to preterm neonates, but lactoferrin concentrations do not.
Clinical and diagnostic laboratory immunology 2001;8(4):818-21.
2001: van Montfoort J E; Müller M; Groothuis G M; Meijer D K; Koepsell H; Meier P J
Comparison of "type I" and "type II" organic cation transport by organic cation transporters and organic anion-transporting polypeptides.
The Journal of pharmacology and experimental therapeutics 2001;298(1):110-5.
2001: Melgert B N; Olinga P; Weert B; Slooff M J; Meijer D K; Poelstra K; Groothuis G M
Cellular distribution and handling of liver-targeting preparations in human livers studied by a liver lobe perfusion.
Drug metabolism and disposition: the biological fate of chemicals 2001;29(6):361-7.
2001: Haverdings R F; Haas M; Greupink A R; de Vries P A; Moolenaar F; de Zeeuw D; Meijer D K
Potentials and limitations of the low-molecular-weight protein lysozyme as a carrier for renal drug targeting.
Renal failure 2001;23(3-4):397-409.
2001: Meijer D K; Beljaars L; Molema G; Poelstra K
Disease-induced drug targeting using novel peptide-ligand albumins.
Journal of controlled release : official journal of the Controlled Release Society 2001;72(1-3):157-64.
2001: Swart P J; Kuipers M E; Smit C; Beljaars L; Ter Wiel J; Meijer D K
The metabolic fate of the Anti-HIV active drug carrier succinylated human serum albumin after intravenous administration in rats.
Journal of drug targeting 2001;9(2):95-109.
2001: Melgert B N; Olinga P; Weert B; Slooff M J; Meijer D K; Poelstra K; Groothuis G M
Cellular distribution and handling of liver-targeting preparations in human livers studied by a liver lobe perfusion.
Drug metabolism and disposition: the biological fate of chemicals 2001;29(4 Pt 1):361-7.
2001: Hooiveld G J; van Montfoort J E; Meijer D K; Müller M
Function and regulation of ATP-binding cassette transport proteins involved in hepatobiliary transport.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2001;12(4):525-43.
2001: Beaufort T M; Proost J H; Maring J; Scheffer E R; Wierda J K; Meijer D K
Effect of hypothermia on the hepatic uptake and biliary excretion of vecuronium in the isolated perfused rat liver.
Anesthesiology 2001;94(2):270-9.
2001: Olinga P; Hof I H; Merema M T; Smit M; de Jager M H; Swart P J; Slooff M J; Meijer D K; Groothuis G M
The applicability of rat and human liver slices to the study of mechanisms of hepatic drug uptake.
Journal of pharmacological and toxicological methods 2001;45(1):55-63.
2001: Molema G; van Veen-Hof I; van Loenen-Weemaes A M; Proost J H; de Leij L F; Meijer D K
Pharmacokinetics and whole body distribution of elastase derived angiostatin (K1-3) in rats.
International journal of cancer. Journal international du cancer 2001;91(1):1-7.
2000: Hooiveld G J; van Montfoort J E; Meijer D K; Müller M
Function and regulation of ATP-binding cassette transport proteins involved in hepatobiliary transport.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2000;12(1):13-30.
2000: Olinga P; Maring J K; Merema M; Hof I H; Slooff M J; Meijer D K; Groothuis G M
The capability of isolated hepatocytes and liver slices of donor livers to predict graft function after liver transplantation.
Liver 2000;20(5):374-80.
2000: Melgert B N; Olinga P; Jack V K; Molema G; Meijer D K; Poelstra K
Dexamethasone coupled to albumin is selectively taken up by rat nonparenchymal liver cells and attenuates LPS-induced activation of hepatic cells.
Journal of hepatology 2000;32(4):603-11.
2000: Beljaars L; Molema G; Schuppan D; Geerts A; De Bleser P J; Weert B; Meijer D K; Poelstra K
Successful targeting to rat hepatic stellate cells using albumin modified with cyclic peptides that recognize the collagen type VI receptor.
The Journal of biological chemistry 2000;275(17):12743-51.
2000: Proost J H; Wierda J M; Houwertjes M C; Roggeveld J; Meijer D K
Structure-pharmacokinetics relationship of series of aminosteroidal neuromuscular blocking agents in the cat.
The Journal of pharmacology and experimental therapeutics 2000;292(3):861-9.
2000: Molema G; Kroesen B J; Helfrich W; Meijer D K; de Leij L F
The use of bispecific antibodies in tumor cell and tumor vasculature directed immunotherapy.
Journal of controlled release : official journal of the Controlled Release Society 2000;64(1-3):229-39.
2000: Molema G; Tervaert J W; Kroesen B J; Helfrich W; Meijer D K; de Leij L F
CD3 directed bispecific antibodies induce increased lymphocyte-endothelial cell interactions in vitro.
British journal of cancer 2000;82(2):472-9.
1999: Swart P J; Harmsen M C; Kuipers M E; Van Dijk A A; Van Der Strate B W; Van Berkel P H; Nuijens J H; Smit C; Witvrouw M; De Clercq E; de Béthune M P; Pauwels R; Meijer D K
Charge modification of plasma and milk proteins results in antiviral active compounds.
Journal of peptide science : an official publication of the European Peptide Society 1999;5(12):563-76.
1999: Swart P J; Hirano T; Kuipers M E; Ito Y; Smit C; Hashida M; Nishikawa M; Beljaars L; Meijer D K; Poelstra K
Targeting of superoxide dismutase to the liver results in anti-inflammatory effects in rats with fibrotic livers.
Journal of hepatology 1999;31(6):1034-43.
1999: Cabrera C; Witvrouw M; Gutiérrez A; Clotet B; Kuipers M E; Swart P J; Meijer D K; Desmyter J; De Clercq E; Esté J A
Resistance of the human immunodeficiency virus to the inhibitory action of negatively charged albumins on virus binding to CD4.
AIDS research and human retroviruses 1999;15(17):1535-43.
1999: Kuipers M E; de Vries H G; Eikelboom M C; Meijer D K; Swart P J
Synergistic fungistatic effects of lactoferrin in combination with antifungal drugs against clinical Candida isolates.
Antimicrobial agents and chemotherapy 1999;43(11):2635-41.
1999: Swart P J; Beljaars L; Kuipers M E; Smit C; Nieuwenhuis P; Meijer D K
Homing of negatively charged albumins to the lymphatic system: general implications for drug targeting to peripheral tissues and viral reservoirs.
Biochemical pharmacology 1999;58(9):1425-35.
1999: van Montfoort J E; Hagenbuch B; Fattinger K E; Müller M; Groothuis G M; Meijer D K; Meier P J
Polyspecific organic anion transporting polypeptides mediate hepatic uptake of amphipathic type II organic cations.
The Journal of pharmacology and experimental therapeutics 1999;291(1):147-52.
1999: Hooiveld G J; Vos T A; Scheffer G L; Van Goor H; Koning H; Bloks V; Loot A E; Meijer D K; Jansen P L; Kuipers F; Müller M
3-Hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors (statins) induce hepatic expression of the phospholipid translocase mdr2 in rats.
Gastroenterology 1999;117(3):678-87.
1999: van Montfoort J E; Stieger B; Meijer D K; Weinmann H J; Meier P J; Fattinger K E
Hepatic uptake of the magnetic resonance imaging contrast agent gadoxetate by the organic anion transporting polypeptide Oatp1.
The Journal of pharmacology and experimental therapeutics 1999;290(1):153-7.
1999: Beljaars L; Molema G; Weert B; Bonnema H; Olinga P; Groothuis G M; Meijer D K; Poelstra K
Albumin modified with mannose 6-phosphate: A potential carrier for selective delivery of antifibrotic drugs to rat and human hepatic stellate cells.
Hepatology (Baltimore, Md.) 1999;29(5):1486-93.
1999: Kuipers M E; vd Berg M; Swart P J; Laman J D; Meijer D K; Koppelman M H; Huisman H
Mechanism of anti-HIV activity of succinylated human serum albumin.
Biochemical pharmacology 1999;57(8):889-98.
1999: Bousquet Y; Swart P J; Schmitt-Colin N; Velge-Roussel F; Kuipers M E; Meijer D K; Bru N; Hoebeke J; Breton P
Molecular mechanisms of the adsorption of a model protein (human serum albumin) on poly(methylidene malonate 2.1.2) nanoparticles.
Pharmaceutical research 1999;16(1):141-7.
1999: Kok R J; Grijpstra F; Walthuis R B; Moolenaar F; de Zeeuw D; Meijer D K
Specific delivery of captopril to the kidney with the prodrug captopril-lysozyme.
The Journal of pharmacology and experimental therapeutics 1999;288(1):281-5.
1999: Meijer D K; Smit J W; Hooiveld G J; van Montfoort J E; Jansen P L; Müller M
The molecular basis for hepatobiliary transport of organic cations and organic anions.
Pharmaceutical biotechnology 1999;12():89-157.
1999: van der Strate B W; Harmsen M C; The T H; Sprenger H G; de Vries H; Eikelboom M C; Kuipers M E; Meijer D K; Swart P J
Plasma lactoferrin levels are decreased in end-stage AIDS patients.
Viral immunology 1999;12(3):197-203.
1999: Meijer D K; Hooiveld G J; Schinkel A H; van Montfoort J E; Haas M; de Zeeuw D; Moolenaar F; Smit J W; Meier P J
Transport mechanisms for cationic drugs and proteins in kidney, liver and intestine: implication for drug interactions and cell-specific drug delivery.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 1999;14 Suppl 4():1-3.
1999: Kuipers M E; Swart P J; Witvrouw M; Esté J A; Reymen D; De Clercq E; Meijer D K
Anti-HIV-1 activity of combinations and covalent conjugates of negatively charged human serum albumins (NCAs) and AZT.
Journal of drug targeting 1999;6(5):323-35.
1998: Vos T A; Hooiveld G J; Koning H; Childs S; Meijer D K; Moshage H; Jansen P L; Müller M
Up-regulation of the multidrug resistance genes, Mrp1 and Mdr1b, and down-regulation of the organic anion transporter, Mrp2, and the bile salt transporter, Spgp, in endotoxemic rat liver.
Hepatology (Baltimore, Md.) 1998;28(6):1637-44.
1998: Beljaars L; Poelstra K; Molema G; Meijer D K
Targeting of sugar- and charge-modified albumins to fibrotic rat livers: the accessibility of hepatic cells after chronic bile duct ligation.
Journal of hepatology 1998;29(4):579-88.
1998: Olinga P; Merema M; Sandker G W; Slooff M J; Meijer D K; Groothuis G M
Uptake of taurocholic acid in human hepatocytes isolated from livers of donors of different age.
Journal of pediatric gastroenterology and nutrition 1998;27(3):366-8.
1998: Smit J W; Weert B; Schinkel A H; Meijer D K
Heterologous expression of various P-glycoproteins in polarized epithelial cells induces directional transport of small (type 1) and bulky (type 2) cationic drugs.
The Journal of pharmacology and experimental therapeutics 1998;286(1):321-7.
1998: Molema G; Meijer D K; de Leij L F
Tumor vasculature targeted therapies: getting the players organized.
Biochemical pharmacology 1998;55(12):1939-45.
1998: Smit J W; Schinkel A H; Weert B; Meijer D K
Hepatobiliary and intestinal clearance of amphiphilic cationic drugs in mice in which both mdr1a and mdr1b genes have been disrupted.
British journal of pharmacology 1998;124(2):416-24.
1998: Molema G; Mesander G; Kroesen B J; Helfrich W; Meijer D K; de Leij L F
Analysis of in vitro lymphocyte adhesion and transendothelial migration by fluorescent-beads-based flow cytometric cell counting.
Cytometry 1998;32(1):37-43.
1998: Olinga P; Merema M; Hof I H; Slooff M J; Proost J H; Meijer D K; Groothuis G M
Characterization of the uptake of rocuronium and digoxin in human hepatocytes: carrier specificity and comparison with in vivo data.
The Journal of pharmacology and experimental therapeutics 1998;285(2):506-10.
1998: Olinga P; Merema M T; Hof I H; De Jager M H; De Jong K P; Slooff M J; Meijer D K; Groothuis G M
Effect of cold and warm ischaemia on drug metabolism in isolated hepatocytes and slices from human and monkey liver.
Xenobiotica; the fate of foreign compounds in biological systems 1998;28(4):349-60.
1998: Hedman A; Meijer D K
Stereoselective inhibition by the diastereomers quinidine and quinine of uptake of cardiac glycosides into isolated rat hepatocytes.
Journal of pharmaceutical sciences 1998;87(4):457-61.
1998: Smit J W; Schinkel A H; Müller M; Weert B; Meijer D K
Contribution of the murine mdr1a P-glycoprotein to hepatobiliary and intestinal elimination of cationic drugs as measured in mice with an mdr1a gene disruption.
Hepatology (Baltimore, Md.) 1998;27(4):1056-63.
1998: de Kanter R; Olinga P; Hof I; de Jager M; Verwillegen W A; Slooff M J; Koster H J; Meijer D K; Groothuis G M
A rapid and simple method for cryopreservation of human liver slices.
Xenobiotica; the fate of foreign compounds in biological systems 1998;28(3):225-34.
1998: Kok R J; Haas M; Moolenaar F; de Zeeuw D; Meijer D K
Drug delivery to the kidneys and the bladder with the low molecular weight protein lysozyme.
Renal failure 1998;20(2):211-7.
1998: Hedman A; Meijer D K
The stereoisomers quinine and quinidine exhibit a marked stereoselectivity in the inhibition of hepatobiliary transport of cardiac glycosides.
Journal of hepatology 1998;28(2):240-9.
1998: Smit J W; Duin E; Steen H; Oosting R; Roggeveld J; Meijer D K
Interactions between P-glycoprotein substrates and other cationic drugs at the hepatic excretory level.
British journal of pharmacology 1998;123(3):361-70.
1998: Olinga P; Merema M; Hof I H; de Jong K P; Slooff M J; Meijer D K; Groothuis G M
Effect of human liver source on the functionality of isolated hepatocytes and liver slices.
Drug metabolism and disposition: the biological fate of chemicals 1998;26(1):5-11.
1998: Faber E D; van den Broek L A; Oosterhuis E E; Stok B P; Meijer D K
The N-benzyl derivative of the glucosidase inhibitor 1-deoxynojirimycin shows a prolonged half-life and a more complete oral absorption in the rat compared with the N-methyl analog.
Drug delivery 1998;5(1):3-12.
1998: Albrecht C; Melgert B N; Reichen J; Poelstra K; Meijer D K
Effect of chronic bile duct obstruction and LPS upon targeting of naproxen to the liver using naproxen-albumin conjugate.
Journal of drug targeting 1998;6(2):105-17.
1998: Swart P J; Kuipers E M; Smit C; Van Der Strate B W; Harmsen M C; Meijer D K
Lactoferrin. Antiviral activity of lactoferrin.
Advances in experimental medicine and biology 1998;443():205-13.
1998: Melgert B N; Wartna E; Lebbe C; Albrecht C; Molema G; Poelstra K; Reichen J; Meijer D K
Targeting of naproxen covalently linked to HSA to sinusoidal cell types of the liver.
Journal of drug targeting 1998;5(5):329-42.
1997: Haas M; Kluppel A C; Wartna E S; Moolenaar F; Meijer D K; de Jong P E; de Zeeuw D
Drug-targeting to the kidney: renal delivery and degradation of a naproxen-lysozyme conjugate in vivo.
Kidney international 1997;52(6):1693-9.
1997: Albrecht C; Meijer D K; Lebbe C; Sägesser H; Melgert B N; Poelstra K; Reichen J
Targeting naproxen coupled to human serum albumin to nonparenchymal cells reduces endotoxin-induced mortality in rats with biliary cirrhosis.
Hepatology (Baltimore, Md.) 1997;26(6):1553-9.
1997: Albrecht C; Reichen J; Visser J; Meijer D K; Thormann W
Differentiation between naproxen, naproxen-protein conjugates, and naproxen-lysine in plasma via micellar electrokinetic capillary chromatography--a new approach in the bioanalysis of drug targeting preparations.
Clinical chemistry 1997;43(11):2083-90.
1997: Olinga P; Merema M; Slooff M J; Meijer D K; Groothuis G M
Influence of 48 hours of cold storage in University of Wisconsin organ preservation solution on metabolic capacity of rat hepatocytes.
Journal of hepatology 1997;27(4):738-43.
1997: Kamps J A; Morselt H W; Swart P J; Meijer D K; Scherphof G L
Massive targeting of liposomes, surface-modified with anionized albumins, to hepatic endothelial cells.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(21):11681-5.
1997: Haas M; Kluppel A C; Moolenaar F; Meijer D K; de Jong P E; de Zeeuw D
Urine collection in the freely moving rat: reliability for measurement of short-term renal effects.
Journal of pharmacological and toxicological methods 1997;38(1):47-51.
1997: Proost J H; Roggeveld J; Wierda J M; Meijer D K
Relationship between chemical structure and physicochemical properties of series of bulky organic cations and their hepatic uptake and biliary excretion rates.
The Journal of pharmacology and experimental therapeutics 1997;282(2):715-26.
1997: Olinga P; Maring J K; Groothuis G M; Kranenburg K; Merema M; Hof I H; Meijer D K; Slooff M J
Value of the in vitro or in vivo monoethylglycinexylidide test for predicting liver graft function.
Transplantation 1997;64(1):60-5.
1997: Haas M; Moolenaar F; Kluppel A C; Dijkstra D; Meijer D K; de Zeeuw D
Determination of dopaminergic prodrugs by high-performance liquid chromatography followed by post-column ion-pair extraction.
Journal of chromatography. B, Biomedical sciences and applications 1997;693(2):484-8.
1997: Kok R J; Visser J; Moolenaar F; de Zeeuw D; Meijer D K
Bioanalysis of captopril: two sensitive high-performance liquid chromatographic methods with pre- or postcolumn fluorescent labeling.
Journal of chromatography. B, Biomedical sciences and applications 1997;693(1):181-9.
1997: Swart P J; Sun C S; Kuipers M E; Asuncion C; Josephs S; Smit C; Meijer D K
The in vitro anti-HIV efficacy of negatively charged human serum albumin is antagonized by heparin.
AIDS research and human retroviruses 1997;13(8):677-83.
1997: Schoen P; Corver J; Meijer D K; Wilschut J; Swart P J
Inhibition of influenza virus fusion by polyanionic proteins.
Biochemical pharmacology 1997;53(7):995-1003.
1997: Molema G; de Leij L F; Meijer D K
Tumor vascular endothelium: barrier or target in tumor directed drug delivery and immunotherapy.
Pharmaceutical research 1997;14(1):2-10.
1997: Kuipers M E; Swart P J; Schutten M; Smit C; Proost J H; Osterhaus A D; Meijer D K
Pharmacokinetics and anti-HIV-1 efficacy of negatively charged human serum albumins in mice.
Antiviral research 1997;33(2):99-108.
1997: Groenink M; Swart P J; Broersen S; Kuipers M; Meijer D K; Schuitemaker H
Potent inhibition of replication of primary HIV type 1 isolates in peripheral blood lymphocytes by negatively charged human serum albumins.
AIDS research and human retroviruses 1997;13(2):179-85.
1997: Lebbe C; Reichen J; Wartna E; Sägesser H; Poelstra K; Meijer D K
Targeting naproxen to non-parenchymal liver cells protects against endotoxin induced liver damage.
Journal of drug targeting 1997;4(5):303-10.
1996: Swart P J; Kuipers M E; Smit C; Pauwels R; deBéthune M P; de Clercq E; Meijer D K; Huisman J G
Antiviral effects of milk proteins: acylation results in polyanionic compounds with potent activity against human immunodeficiency virus types 1 and 2 in vitro.
AIDS research and human retroviruses 1996;12(9):769-75.
1996: Kuipers M E; Huisman J G; Swart P J; de Béthune M P; Pauwels R; Schuitemaker H; De Clercq E; Meijer D K
Mechanism of anti-HIV activity of negatively charged albumins: biomolecular interaction with the HIV-1 envelope protein gp120.
Journal of acquired immune deficiency syndromes and human retrovirology : official publication of the International Retrovirology Association 1996;11(5):419-29.
1996: Proost J H; Wierda J M; Meijer D K
An extended pharmacokinetic/pharmacodynamic model describing quantitatively the influence of plasma protein binding, tissue binding, and receptor binding on the potency and time course of action of drugs.
Journal of pharmacokinetics and biopharmaceutics 1996;24(1):45-77.
1996: Kamps J A; Swart P J; Morselt H W; Pauwels R; De Béthune M P; De Clercq E; Meijer D K; Scherphof G L
Preparation and characterization of conjugates of (modified) human serum albumin and liposomes: drug carriers with an intrinsic anti-HIV activity.
Biochimica et biophysica acta 1996;1278(2):183-90.
1996: Groothuis G M; Meijer D K
Drug traffic in the hepatobiliary system.
Journal of hepatology 1996;24 Suppl 1():3-28.
1996: Swart P J; Beljaars E; Smit C; Pasma A; Schuitemaker H; Meijer D K
Comparative pharmacokinetic, immunologic and hematologic studies on the anti-HIV-1/2 compounds aconitylated and succinylated HSA.
Journal of drug targeting 1996;4(2):109-16.
1995: Harmsen M C; Swart P J; de Béthune M P; Pauwels R; De Clercq E; The T H; Meijer D K
Antiviral effects of plasma and milk proteins: lactoferrin shows potent activity against both human immunodeficiency virus and human cytomegalovirus replication in vitro.
The Journal of infectious diseases 1995;172(2):380-8.
1995: Kuipers M E; Swart P J; Hendriks M M; Meijer D K
Optimization of the reaction conditions for the synthesis of neoglycoprotein-AZT-monophosphate conjugates.
Journal of medicinal chemistry 1995;38(6):883-9.
1994: Steen H; Merema M; Meijer D K
Effect of ethanol on hepatobiliary transport of cationic drugs. A study in the isolated perfused rat liver, rat hepatocytes and rat mitochondria.
Journal of hepatology 1994;21(3):308-14.
1994: Nijssen H M; Pijning T; Proost J H; Meijer D K; Groothuis G M
The sinusoidal efflux of dibromosulfophthalein from rat liver is stimulated by albumin, ligandin and fatty acid binding protein but not by other dibromosulfophthalein binding proteins.
Journal of hepatology 1994;21(1):29-36.
1994: Sandker G W; Weert B; Olinga P; Wolters H; Slooff M J; Meijer D K; Groothuis G M
Characterization of transport in isolated human hepatocytes. A study with the bile acid taurocholic acid, the uncharged ouabain and the organic cations vecuronium and rocuronium.
Biochemical pharmacology 1994;47(12):2193-200.
1994: Sandker G W; Vos R M; Delbressine L P; Slooff M J; Meijer D K; Groothuis G M
Metabolism of three pharmacologically active drugs in isolated human and rat hepatocytes: analysis of interspecies variability and comparison with metabolism in vivo.
Xenobiotica; the fate of foreign compounds in biological systems 1994;24(2):143-55.
1994: Faber E D; Proost J H; Oosting R; Meijer D K
Disposition of glycosidase inhibitors in the isolated perfused rat liver: hepatobiliary and subcellular concentration gradients of 1-deoxymannojirimycin and N-methyl-1-deoxynojirimycin.
Pharmaceutical research 1994;11(1):144-50.
1993: Sandker G W; Weert B; Merema M T; Kuipers W; Slooff M J; Meijer D K; Groothuis G M
Maintenance of viability and transport function after preservation of isolated rat hepatocytes in various simplified University of Wisconsin solutions.
Biochemical pharmacology 1993;46(11):2093-6.
1993: Jansen R W; Olinga P; Harms G; Meijer D K
Pharmacokinetic analysis and cellular distribution of the anti-HIV compound succinylated human serum albumin (Suc-HSA) in vivo and in the isolated perfused rat liver.
Pharmaceutical research 1993;10(11):1611-4.
1993: Steen H; Smit H; Nijholt A; Merema M; Meijer D K
Modulators of the protein kinase C system influence biliary excretion of cationic drugs.
Hepatology (Baltimore, Md.) 1993;18(5):1208-15.
1993: Jansen R W; Schols D; Pauwels R; De Clercq E; Meijer D K
Novel, negatively charged, human serum albumins display potent and selective in vitro anti-human immunodeficiency virus type 1 activity.
Molecular pharmacology 1993;44(5):1003-7.
1993: Proost J H; Nijssen H M; Strating C B; Meijer D K; Groothuis G M
Pharmacokinetic modeling of the sinusoidal efflux of anionic ligands from the isolated perfused rat liver: the influence of albumin.
Journal of pharmacokinetics and biopharmaceutics 1993;21(4):375-94.
1993: Franssen E J; Moolenaar F; de Zeeuw D; Meijer D K
Low molecular weight proteins as carriers for renal drug targeting: naproxen coupled to lysozyme via the spacer L-lactic acid.
Pharmaceutical research 1993;10(7):963-9.
1993: Jansen R W; Kruijt J K; van Berkel T J; Meijer D K
Coupling of the antiviral drug ara-AMP to lactosaminated albumin leads to specific uptake in rat and human hepatocytes.
Hepatology (Baltimore, Md.) 1993;18(1):146-52.
1993: Beaufort A M; Wierda J M; Houwertjes M C; Kleef U W; Meijer D K
The isolated heart-lung preparation in the cat. An in situ model to study the role of the lungs in the disposition of drugs.
Journal of pharmacological and toxicological methods 1993;29(3):147-56.
1993: Meijer D K
Drug targeting to the liver with bile acids: the "Trojan horse" resurrected?
Hepatology (Baltimore, Md.) 1993;17(5):945-8.
1993: Lanting A B; Bruins A P; Drenth B F; de Jonge K; Ensing K; de Zeeuw R A; Meijer D K
Identification with liquid chromatography-ionspray mass spectrometry of the metabolites of the enantiomers N-methyl dextrorphan and N-methyl levorphanol after rat liver perfusion.
Biological mass spectrometry 1993;22(4):226-34.
1993: Steen H; Maring J G; Meijer D K
Differential effects of metabolic inhibitors on cellular and mitochondrial uptake of organic cations in rat liver.
Biochemical pharmacology 1993;45(4):809-18.
1993: Franssen E J; Moolenaar F; de Zeeuw D; Meijer D K
Low-molecular-weight proteins as carriers for renal drug targeting.
Contributions to nephrology 1993;101():99-103.
1993: Haas M; de Zeeuw D; Meijer D K
Quantification of renal low-molecular-weight protein degradation in the intact rat.
Contributions to nephrology 1993;101():78-84.
1992: Steen H; Merema M; Meijer D K
A multispecific uptake system for taurocholate, cardiac glycosides and cationic drugs in the liver.
Biochemical pharmacology 1992;44(12):2323-31.
1992: Faber E D; Oosting R; Neefjes J J; Ploegh H L; Meijer D K
Distribution and elimination of the glycosidase inhibitors 1-deoxymannojirimycin and N-methyl-1-deoxynojirimycin in the rat in vivo.
Pharmaceutical research 1992;9(11):1442-50.
1992: Mol W E; Rombout F; Paanakker J E; Oosting R; Scaf A H; Meijer D K
Pharmacokinetics of steroidal muscle relaxants in isolated perfused rat liver.
Biochemical pharmacology 1992;44(7):1453-9.
1992: Molema G; Jansen R W; Visser J; Meijer D K
Simultaneous analysis of azidothymidine and its mono-, di- and triphosphate derivatives in biological fluids, tissue and cultured cells by a rapid high-performance liquid chromatographic method.
Journal of chromatography 1992;579(1):107-14.
1992: Moolenaar F; Crancrinus S; Visser J; De Zeeuw D; Meijer D K
Clearance of indomethacin occurs predominantly by renal glucuronidation.
Pharmaceutisch weekblad. Scientific edition 1992;14(4):191-5.
1992: Meijer D K; Jansen R W; Molema G
Drug targeting systems for antiviral agents: options and limitations.
Antiviral research 1992;18(3-4):215-58.
1992: Proost J H; Meijer D K
MW/Pharm, an integrated software package for drug dosage regimen calculation and therapeutic drug monitoring.
Computers in biology and medicine 1992;22(3):155-63.
1992: Mol W E; Müller M; Kurz G; Meijer D K
Investigations on the hepatic uptake systems for organic cations with a photoaffinity probe of procainamide ethobromide.
Biochemical pharmacology 1992;43(10):2217-26.
1992: Franssen E J; Koiter J; Kuipers C A; Bruins A P; Moolenaar F; de Zeeuw D; Kruizinga W H; Kellogg R M; Meijer D K
Low molecular weight proteins as carriers for renal drug targeting. Preparation of drug-protein conjugates and drug-spacer derivatives and their catabolism in renal cortex homogenates and lysosomal lysates.
Journal of medicinal chemistry 1992;35(7):1246-59.
1992: Nijssen H M; Pijning T; Meijer D K; Groothuis G M
Influence of albumin on the net sinusoidal efflux of the organic anion dibromosulfophthalein from rat liver.
Hepatology (Baltimore, Md.) 1992;15(2):302-9.
1991: Wierda J M; Szenohradszky J; De Wit A P; Zentai G; Agoston S; Kakas M; Kleef U W; Meijer D K
The pharmacokinetics, urinary and biliary excretion of pipecuronium bromide.
European journal of anaesthesiology 1991;8(6):451-7.
1991: Franssen E J; van Amsterdam R G; Visser J; Moolenaar F; de Zeeuw D; Meijer D K
Low molecular weight proteins as carriers for renal drug targeting: naproxen-lysozyme.
Pharmaceutical research 1991;8(10):1223-30.
1991: Nijssen H M; Pijning T; Meijer D K; Groothuis G M
Mechanistic aspects of uptake and sinusoidal efflux of dibromosulfophthalein in the isolated perfused rat liver.
Biochemical pharmacology 1991;42(10):1997-2002.
1991: Jansen R W; Molema G; Harms G; Kruijt J K; van Berkel T J; Hardonk M J; Meijer D K
Formaldehyde treated albumin contains monomeric and polymeric forms that are differently cleared by endothelial and Kupffer cells of the liver: evidence for scavenger receptor heterogeneity.
Biochemical and biophysical research communications 1991;180(1):23-32.
1991: Steen H; Oosting R; Meijer D K
Mechanisms for the uptake of cationic drugs by the liver: a study with tributylmethylammonium (TBuMA).
The Journal of pharmacology and experimental therapeutics 1991;258(2):537-43.
1991: Jansen R W; Molema G; Pauwels R; Schols D; De Clercq E; Meijer D K
Potent in vitro anti-human immunodeficiency virus-1 activity of modified human serum albumins.
Molecular pharmacology 1991;39(6):818-23.
1991: Frijlink H W; Franssen E J; Eissens A C; Oosting R; Lerk C F; Meijer D K
The effects of cyclodextrins on the disposition of intravenously injected drugs in the rat.
Pharmaceutical research 1991;8(3):380-4.
1991: Molema G; Jansen R W; Visser J; Herdewijn P; Moolenaar F; Meijer D K
Neoglycoproteins as carriers for antiviral drugs: synthesis and analysis of protein-drug conjugates.
Journal of medicinal chemistry 1991;34(3):1137-41.
1991: Jansen R W; Molema G; Ching T L; Oosting R; Harms G; Moolenaar F; Hardonk M J; Meijer D K
Hepatic endocytosis of various types of mannose-terminated albumins. What is important, sugar recognition, net charge, or the combination of these features.
The Journal of biological chemistry 1991;266(5):3343-8.
1991: Frijlink H W; Eissens A C; Hefting N R; Poelstra K; Lerk C F; Meijer D K
The effect of parenterally administered cyclodextrins on cholesterol levels in the rat.
Pharmaceutical research 1991;8(1):9-16.
1991: Braakman I; Keij J; Hardonk M J; Meijer D K; Groothuis G M
Separation of periportal and perivenous rat hepatocytes by fluorescence-activated cell sorting: confirmation with colloidal gold as an exogenous marker.
Hepatology (Baltimore, Md.) 1991;13(1):73-82.
1990: Frijlink H W; Visser J; Hefting N R; Oosting R; Meijer D K; Lerk C F
The pharmacokinetics of beta-cyclodextrin and hydroxypropyl-beta-cyclodextrin in the rat.
Pharmaceutical research 1990;7(12):1248-52.
1990: Molema G; Jansen R W; Pauwels R; de Clercq E; Meijer D K
Targeting of antiviral drugs to T4-lymphocytes. Anti-HIV activity of neoglycoprotein-AZTMP conjugates in vitro.
Biochemical pharmacology 1990;40(12):2603-10.
1990: Wierda J M; Karliczek G F; Vandenbrom R H; Pinto I; Kersten-Kleef U W; Meijer D K; Agoston S
Pharmacokinetics and cardiovascular dynamics of pipecuronium bromide during coronary artery surgery.
Canadian journal of anaesthesia = Journal canadien d'anesthésie 1990;37(2):183-91.
1990: Meijer D K; Mol W E; Müller M; Kurz G
Carrier-mediated transport in the hepatic distribution and elimination of drugs, with special reference to the category of organic cations.
Journal of pharmacokinetics and biopharmaceutics 1990;18(1):35-70.
1990: Mol W E; Meijer D K
Hepatic transport mechanisms for bivalent organic cations. Subcellular distribution and hepato-biliary concentration gradients of some steroidal muscle relaxants.
Biochemical pharmacology 1990;39(2):383-90.
1989: Braakman I; Pijning T; Verest O; Weert B; Meijer D K; Groothuis G M
Vesicular uptake system for the cation lucigenin in the rat hepatocyte.
Molecular pharmacology 1989;36(4):537-42.
1989: Braakman I; Verest O; Pijning T; Meijer D K; Groothuis G M
Zonal distribution of the cation lucigenin in rat liver: influence of taurocholate.
Molecular pharmacology 1989;36(4):532-6.
1989: Braakman I; Groothuis G M; Meijer D K
Zonal compartmentation of perfused rat liver: plasma reappearance of rhodamine B explained.
The Journal of pharmacology and experimental therapeutics 1989;249(3):869-73.
1989: Meijer D K; van der Sluijs P
Covalent and noncovalent protein binding of drugs: implications for hepatic clearance, storage, and cell-specific drug delivery.
Pharmaceutical research 1989;6(2):105-18.
1989: Feitsma K G; Drenth B F; De Zeeuw R A; Oosting R; Meijer D K
Unequal disposition of enantiomers of the organic cation oxyphenonium in the rat isolated perfused liver.
The Journal of pharmacy and pharmacology 1989;41(1):27-31.
1989: Meijer D K; van der Sluijs P
Binding of drugs to alpha 1-acid glycoprotein and its desialylated form. Influence on hepatic disposition and implications for drug targeting to the liver.
Progress in clinical and biological research 1989;300():143-67.
1988: van der Sluijs P; Braakman I; Meijer D K; Groothuis G M
Heterogeneous acinar localization of the asialoglycoprotein internalization system in rat hepatocytes.
Hepatology (Baltimore, Md.) 1988;8(6):1521-9.
1988: Bencini A F; Mol W E; Scaf A H; Kersten U W; Wolters K T; Agoston S; Meijer D K
Uptake and excretion of vecuronium bromide and pancuronium bromide in the isolated perfused rat liver.
Anesthesiology 1988;69(4):487-92.
1988: Mol W E; Fokkema G N; Weert B; Meijer D K
Mechanisms for the hepatic uptake of organic cations. Studies with the muscle relaxant vecuronium in isolated rat hepatocytes.
The Journal of pharmacology and experimental therapeutics 1988;244(1):268-75.
1988: Meijer D K; Weert B; Vermeer G A
Pharmacokinetics of biliary excretion in man. VI. Indocyanine green.
European journal of clinical pharmacology 1988;35(3):295-303.
1987: Braakman I; Groothuis G M; Meijer D K
Acinar redistribution and heterogeneity in transport of the organic cation rhodamine B in rat liver.
Hepatology (Baltimore, Md.) 1987;7(5):849-55.
1985: van der Sluijs P; Oosting R; Weitering J G; Hardonk M J; Meijer D K
Biliary excretion of FITC metabolites after administration of FITC labeled asialo orosomucoid as a measure of lysosomal proteolysis.
Biochemical pharmacology 1985;34(9):1399-405.
1983: Groothuis G M; Keulemans K P; Hardonk M J; Meijer D K
Acinar heterogeneity in hepatic transport of dibromosulfophthalein and ouabain studied by autoradiography, normal and retrograde perfusions and computer simulation.
Biochemical pharmacology 1983;32(20):3069-78.
1983: Groothuis G M; Weitering J G; Hardonk M J; Meijer D K
Heterogeneity of rat hepatocytes in transport and hepatic binding of asialoalkaline phosphatase studied after induction of selective acinar damage by N-hydroxy-2-acetylaminofluorene and carbon tetrachloride.
Biochemical pharmacology 1983;32(18):2721-7.
1983: Russel F G; Weitering J G; Oosting R; Groothuis G M; Hardonk M J; Meijer D K
Influence of taurocholate on hepatic clearance and biliary excretion of asialo intestinal alkaline phosphatase in the rat in vivo and in isolated perfused rat liver.
Gastroenterology 1983;85(2):225-34.
1983: Groothuis G M; Weitering J G; Keulemans K P; Hardonk M J; Mulder D; Meijer D K
Heterogeneity of rat hepatocytes in bile acid and DBSP transport studied after induction of selective acinar damage by N-hydroxy-2-acetylaminofluorene and carbon tetrachloride.
Naunyn-Schmiedeberg's archives of pharmacology 1983;322(4):310-8.
1982: Groothuis G M; Hardonk M J; Keulemans K P; Nieuwenhuis P; Meijer D K
Autoradiographic and kinetic demonstration of acinar heterogeneity of taurocholate transport.
The American journal of physiology 1982;243(6):G455-62.
1981: Westra P; Vermeer G A; de Lange A R; Scaf A H; Meijer D K; Wesseling H
Hepatic and renal disposition of pancuronium and gallamine in patients with extrahepatic cholestasis.
British journal of anaesthesia 1981;53(4):331-8.
1981: Westra P; Houwertjes M C; Wesseling H; Meijer D K
Bile salts and neuromuscular blocking agents.
British journal of anaesthesia 1981;53(4):407-15.
1981: Westra P; Keulemans G T; Houwertjes M C; Hardonk M J; Meijer D K
Mechanisms underlying the prolonged duration of action of muscle relaxants caused by extrahepatic cholestasis.
British journal of anaesthesia 1981;53(3):217-27.

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