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Laurent Meijer
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21
Leost, Maryse
19
Ferandin, Yoan
14
Kunick, Conrad
12
Lozach, Olivier
11
Zaharevitz, Daniel
10
Bettayeb, Karima
10
Gussio, Rick
10
Knockaert, Marie
9
Greengard, Paul
8
Magiatis, Prokopios
7
Skaltsounis, Alexios-Leandros
7
Bach, Stéphane
7
Doerig, Christian
6
Eisenbrand, Gerhard
6
Galons, Hervé
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All Publications
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2009: Beauchard Anne; Laborie Hélène; Rouillard Hervé; Lozach Olivier; Ferandin Yoan; Le Guével Rémy; Guguen-Guillouzo Christiane; Meijer Laurent; Besson Thierry; Thiéry Valérie
Synthesis and kinase inhibitory activity of novel substituted indigoids.
Bioorganic & medicinal chemistry 2009;17(17):6257-63.
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2009: Akue-Gedu Rufine; Debiton Eric; Ferandin Yoan; Meijer Laurent; Prudhomme Michelle; Anizon Fabrice; Moreau Pascale
Synthesis and biological activities of aminopyrimidyl-indoles structurally related to meridianins.
Bioorganic & medicinal chemistry 2009;17(13):4420-4.
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2009: Popowycz Florence; Fournet Guy; Schneider Cédric; Bettayeb Karima; Ferandin Yoan; Lamigeon Cyrile; Tirado Oscar M; Mateo-Lozano Silvia; Notario Vicente; Colas Pierre; Bernard Philippe; Meijer Laurent; Joseph Benoît
Pyrazolo[1,5-a]-1,3,5-triazine as a purine bioisostere: access to potent cyclin-dependent kinase inhibitor (R)-roscovitine analogue.
Journal of medicinal chemistry 2009;52(3):655-63.
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2008: Vougogiannopoulou Konstantina; Ferandin Yoan; Bettayeb Karima; Myrianthopoulos Vassilios; Lozach Olivier; Fan Yunzhen; Johnson Carl Hirschie; Magiatis Prokopios; Skaltsounis Alexios-Leandros; Mikros Emmanuel; Meijer Laurent
Soluble 3',6-substituted indirubins with enhanced selectivity toward glycogen synthase kinase -3 alter circadian period.
Journal of medicinal chemistry 2008;51(20):6421-31.
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2008: Bettayeb K; Oumata N; Echalier A; Ferandin Y; Endicott J A; Galons H; Meijer L
CR8, a potent and selective, roscovitine-derived inhibitor of cyclin-dependent kinases.
Oncogene 2008;27(44):5797-807.
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2008: Bettayeb Karima; Sallam Hatem; Ferandin Yoan; Popowycz Florence; Fournet Guy; Hassan Moustapha; Echalier Aude; Bernard Philippe; Endicott Jane; Joseph Benoît; Meijer Laurent
N-&-N, a new class of cell death-inducing kinase inhibitors derived from the purine roscovitine.
Molecular cancer therapeutics 2008;7(9):2713-24.
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2008: Oumata Nassima; Bettayeb Karima; Ferandin Yoan; Demange Luc; Lopez-Giral Angela; Goddard Marie-Lorène; Myrianthopoulos Vassilios; Mikros Emmanuel; Flajolet Marc; Greengard Paul; Meijer Laurent; Galons Hervé
Roscovitine-derived, dual-specificity inhibitors of cyclin-dependent kinases and casein kinases 1.
Journal of medicinal chemistry 2008;51(17):5229-42.
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2008: Logé Cédric; Testard Alexandra; Thiéry Valérie; Lozach Olivier; Blairvacq Mélina; Robert Jean-Michel; Meijer Laurent; Besson Thierry
Novel 9-oxo-thiazolo[5,4-f]quinazoline-2-carbonitrile derivatives as dual cyclin-dependent kinase 1 (CDK1)/glycogen synthase kinase-3 (GSK-3) inhibitors: synthesis, biological evaluation and molecular modeling studies.
European journal of medicinal chemistry 2008;43(7):1469-77.
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2008: Jacquemard Ulrich; Dias Nathalie; Lansiaux Amélie; Bailly Christian; Logé Cédric; Robert Jean-Michel; Lozach Olivier; Meijer Laurent; Mérour Jean-Yves; Routier Sylvain
Synthesis of 3,5-bis(2-indolyl)pyridine and 3-[(2-indolyl)-5-phenyl]pyridine derivatives as CDK inhibitors and cytotoxic agents.
Bioorganic & medicinal chemistry 2008;16(9):4932-53.
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2008: Stukenbrock Hendrik; Mussmann Rainer; Geese Marcus; Ferandin Yoan; Lozach Olivier; Lemcke Thomas; Kegel Simone; Lomow Alexander; Burk Ulrike; Dohrmann Cord; Meijer Laurent; Austen Matthias; Kunick Conrad
9-cyano-1-azapaullone (cazpaullone), a glycogen synthase kinase-3 (GSK-3) inhibitor activating pancreatic beta cell protection and replication.
Journal of medicinal chemistry 2008;51(7):2196-207.
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2008: Olivier David; Poincelot Marie-Anne; Douillard Samuel; Lefevre Carine; Moureau Julien; Ferandin Yoan; Bettayeb Karima; Xiao Zhijian; Magiatis Prokopios; Skaltsounis Leandros; Meijer Laurent; Patrice Thierry
Photoreactivity of indirubin derivatives.
Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology 2008;7(3):328-36.
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2008: Echalier Aude; Bettayeb Karima; Ferandin Yoan; Lozach Olivier; Clément Monique; Valette Annie; Liger François; Marquet Bernard; Morris Jonathan C; Endicott Jane A; Joseph Benoît; Meijer Laurent
Meriolins (3-(pyrimidin-4-yl)-7-azaindoles): synthesis, kinase inhibitory activity, cellular effects, and structure of a CDK2/cyclin A/meriolin complex.
Journal of medicinal chemistry 2008;51(4):737-51.
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2008: Baunbaek Dianne; Trinkler Nolwenn; Ferandin Yoan; Lozach Olivier; Ploypradith Poonsakdi; Rucirawat Somsak; Ishibashi Fumito; Iwao Masatomo; Meijer Laurent
Anticancer alkaloid lamellarins inhibit protein kinases.
Marine drugs 2008;6(4):514-27.
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2007: Bettayeb Karima; Tirado Oscar M; Marionneau-Lambot Séverine; Ferandin Yoan; Lozach Olivier; Morris Jonathan C; Mateo-Lozano Silvia; Drueckes Peter; Schächtele Christoph; Kubbutat Michael H G; Liger François; Marquet Bernard; Joseph Benoît; Echalier Aude; Endicott Jane A; Notario Vicente; Meijer Laurent
Meriolins, a new class of cell death inducing kinase inhibitors with enhanced selectivity for cyclin-dependent kinases.
Cancer research 2007;67(17):8325-34.
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2007: Myrianthopoulos Vassilios; Magiatis Prokopios; Ferandin Yoan; Skaltsounis Alexios-Leandros; Meijer Laurent; Mikros Emmanuel
An integrated computational approach to the phenomenon of potent and selective inhibition of aurora kinases B and C by a series of 7-substituted indirubins.
Journal of medicinal chemistry 2007;50(17):4027-37.
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2007: Reinhardt Jens; Ferandin Yoan; Meijer Laurent
Purification of CK1 by affinity chromatography on immobilised axin.
Protein expression and purification 2007;54(1):101-9.
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2007: Doerig Christian; Meijer Laurent
Antimalarial drug discovery: targeting protein kinases.
Expert opinion on therapeutic targets 2007;11(3):279-90.
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2007: Guiffant Damien; Tribouillard Déborah; Gug Fabienne; Galons Hervé; Meijer Laurent; Blondel Marc; Bach Stéphane
Identification of intracellular targets of small molecular weight chemical compounds using affinity chromatography.
Biotechnology journal 2007;2(1):68-75.
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2007: Vandromme Lucie; Legraverend Michel; Kreimerman Sergio; Lozach Olivier; Meijer Laurent; Grierson David S
A Pd(0) based cross-coupling approach to the synthesis of 2-amidopurines and their evaluation as CDK inhibitors.
Bioorganic & medicinal chemistry 2007;15(1):130-41.
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2006: Iurisci Ida; Filipski Elisabeth; Reinhardt Jens; Bach Stéphane; Gianella-Borradori Athos; Iacobelli Stefano; Meijer Laurent; Lévi Francis
Improved tumor control through circadian clock induction by Seliciclib, a cyclin-dependent kinase inhibitor.
Cancer research 2006;66(22):10720-8.
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2006: Ribas J; Bettayeb K; Ferandin Y; Knockaert M; Garrofé-Ochoa X; Totzke F; Schächtele C; Mester J; Polychronopoulos P; Magiatis P; Skaltsounis A-L; Boix J; Meijer L
7-Bromoindirubin-3'-oxime induces caspase-independent cell death.
Oncogene 2006;25(47):6304-18.
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2006: Beauchard Anne; Ferandin Yoan; Frère Stéphane; Lozach Olivier; Blairvacq Mélina; Meijer Laurent; Thiéry Valérie; Besson Thierry
Synthesis of novel 5-substituted indirubins as protein kinases inhibitors.
Bioorganic & medicinal chemistry 2006;14(18):6434-43.
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2006: Ferandin Yoan; Bettayeb Karima; Kritsanida Marina; Lozach Olivier; Polychronopoulos Panagiotis; Magiatis Prokopios; Skaltsounis Alexios-Leandros; Meijer Laurent
3'-Substituted 7-halogenoindirubins, a new class of cell death inducing agents.
Journal of medicinal chemistry 2006;49(15):4638-49.
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2006: Ribas Judit; Boix Jacint; Meijer Laurent
(R)-roscovitine (CYC202, Seliciclib) sensitizes SH-SY5Y neuroblastoma cells to nutlin-3-induced apoptosis.
Experimental cell research 2006;312(12):2394-400.
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2006: Testard Alexandra; Logé Cédric; Léger Benoît; Robert Jean-Michel; Lozach Olivier; Blairvacq Mélina; Meijer Laurent; Thiéry Valérie; Besson Thierry
Thiazolo[5,4-f]quinazolin-9-ones, inhibitors of glycogen synthase kinase-3.
Bioorganic & medicinal chemistry letters 2006;16(13):3419-23.
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2006: Laurent Dominique; Jullian Valérie; Parenty Arnaud; Knibiehler Martine; Dorin Dominique; Schmitt Sophie; Lozach Olivier; Lebouvier Nicolas; Frostin Maryvonne; Alby Frédéric; Maurel Séverine; Doerig Christian; Meijer Laurent; Sauvain Michel
Antimalarial potential of xestoquinone, a protein kinase inhibitor isolated from a Vanuatu marine sponge Xestospongia sp.
Bioorganic & medicinal chemistry 2006;14(13):4477-82.
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2006: Barluenga Sofia; Dakas Pierre-Yves; Ferandin Yoan; Meijer Laurent; Winssinger Nicolas
Modular asymmetric synthesis of aigialomycin D, a kinase-inhibitory scaffold.
Angewandte Chemie (International ed. in English) 2006;45(24):3951-4.
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2006: Vandromme Lucie; Piguel Sandrine; Lozach Olivier; Meijer Laurent; Legraverend Michel; Grierson David S
Suzuki-type Pd(0) coupling reactions in the synthesis of 2-arylpurines as Cdk inhibitors.
Bioorganic & medicinal chemistry letters 2006;16(12):3144-6.
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2005: Testard Alexandra; Picot Laurent; Lozach Olivier; Blairvacq Melina; Meijer Laurent; Murillo Laurence; Piot Jean-Marie; Thiéry Valérie; Besson Thierry
Synthesis and evaluation of the antiproliferative activity of novel thiazoloquinazolinone kinases inhibitors.
Journal of enzyme inhibition and medicinal chemistry 2005;20(6):557-68.
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2005: Tang Lin; Li Ming-Hui; Cao Peng; Wang Feng; Chang Wen-Rui; Bach Stéphane; Reinhardt Jens; Ferandin Yoan; Galons Hervé; Wan Yongqin; Gray Nathanael; Meijer Laurent; Jiang Tao; Liang Dong-Cai
Crystal structure of pyridoxal kinase in complex with roscovitine and derivatives.
The Journal of biological chemistry 2005;280(35):31220-9.
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2005: Bach Stéphane; Knockaert Marie; Reinhardt Jens; Lozach Olivier; Schmitt Sophie; Baratte Blandine; Koken Marcel; Coburn Stephen P; Tang Lin; Jiang Tao; Liang Dong-Cai; Galons Hervé; Dierick Jean-Francois; Pinna Lorenzo A; Meggio Flavio; Totzke Frank; Schächtele Christoph; Lerman Andrea S; Carnero Amancio; Wan Yongqin; Gray Nathanael; Meijer Laurent
Roscovitine targets, protein kinases and pyridoxal kinase.
The Journal of biological chemistry 2005;280(35):31208-19.
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2005: Xie Xu; Lemcke Thomas; Gussio Rick; Zaharevitz Daniel W; Leost Maryse; Meijer Laurent; Kunick Conrad
Epoxide-containing side chains enhance antiproliferative activity of paullones.
European journal of medicinal chemistry 2005;40(7):655-61.
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2005: Blondel Marc; Bach Stéphane; Bamps Sophie; Dobbelaere Jeroen; Wiget Philippe; Longaretti Céline; Barral Yves; Meijer Laurent; Peter Matthias
Degradation of Hof1 by SCF(Grr1) is important for actomyosin contraction during cytokinesis in yeast.
The EMBO journal 2005;24(7):1440-52.
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2005: Kunick Conrad; Zeng Zhihong; Gussio Rick; Zaharevitz Daniel; Leost Maryse; Totzke Frank; Schächtele Christoph; Kubbutat Michael H G; Meijer Laurent; Lemcke Thomas
Structure-aided optimization of kinase inhibitors derived from alsterpaullone.
Chembiochem : a European journal of chemical biology 2005;6(3):541-9.
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2005: Lu Heshu; Chang Debbie J; Baratte Blandine; Meijer Laurent; Schulze-Gahmen Ursula
Crystal structure of a human cyclin-dependent kinase 6 complex with a flavonol inhibitor, fisetin.
Journal of medicinal chemistry 2005;48(3):737-43.
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2005: Voigt Burkhardt; Meijer Laurent; Lozach Olivier; Schächtele Christoph; Totzke Frank; Hilgeroth Andreas
Novel CDK inhibition profiles of structurally varied 1-aza-9-oxafluorenes.
Bioorganic & medicinal chemistry letters 2005;15(3):823-5.
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2004: Duensing Stefan; Duensing Anette; Lee David C; Edwards Kirsten M; Piboonniyom Siribang-On; Manuel Edwin; Skaltsounis Leandros; Meijer Laurent; Münger Karl
Cyclin-dependent kinase inhibitor indirubin-3'-oxime selectively inhibits human papillomavirus type 16 E7-induced numerical centrosome anomalies.
Oncogene 2004;23(50):8206-15.
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2004: Meijer Laurent; Flajolet Marc; Greengard Paul
Pharmacological inhibitors of glycogen synthase kinase 3.
Trends in pharmacological sciences 2004;25(9):471-80.
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2004: Pies Tanja; Schaper Klaus-Jürgen; Leost Maryse; Zaharevitz Daniel W; Gussio Rick; Meijer Laurent; Kunicke Conrad
CDK1-inhibitory activity of paullones depends on electronic properties of 9-substituents.
Archiv der Pharmazie 2004;337(9):486-92.
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2004: Grant Karen M; Dunion Morag H; Yardley Vanessa; Skaltsounis Alexios-Leandros; Marko Doris; Eisenbrand Gerhard; Croft Simon L; Meijer Laurent; Mottram Jeremy C
Inhibitors of Leishmania mexicana CRK3 cyclin-dependent kinase: chemical library screen and antileishmanial activity.
Antimicrobial agents and chemotherapy 2004;48(8):3033-42.
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2004: Knockaert Marie; Blondel Marc; Bach Stéphane; Leost Maryse; Elbi Cem; Hager Gordon L; Nagy Scott R; Han Dalho; Denison Michael; Ffrench Martine; Ryan Xiaozhou P; Magiatis Prokopios; Polychronopoulos Panos; Greengard Paul; Skaltsounis Leandros; Meijer Laurent
Independent actions on cyclin-dependent kinases and aryl hydrocarbon receptor mediate the antiproliferative effects of indirubins.
Oncogene 2004;23(25):4400-12.
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2004: Gompel Marie; Soulié Cathia; Ceballos-Picot Irène; Meijer Laurent
Expression and activity of cyclin-dependent kinases and glycogen synthase kinase-3 during NT2 neuronal differentiation.
Neuro-Signals 2004;13(3):134-43.
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2004: Gompel Marie; Leost Maryse; De Kier Joffe Elisa Bal; Puricelli Lydia; Franco Laura Hernandez; Palermo Jorge; Meijer Laurent
Meridianins, a new family of protein kinase inhibitors isolated from the ascidian Aplidium meridianum.
Bioorganic & medicinal chemistry letters 2004;14(7):1703-7.
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2004: Droucheau Eliane; Primot Aline; Thomas Virginie; Mattei Denise; Knockaert Marie; Richardson Chris; Sallicandro Pina; Alano Pietro; Jafarshad Ali; Baratte Blandine; Kunick Conrad; Parzy Daniel; Pearl Laurence; Doerig Christian; Meijer Laurent
Plasmodium falciparum glycogen synthase kinase-3: molecular model, expression, intracellular localisation and selective inhibitors.
Biochimica et biophysica acta 2004;1697(1-2):181-96.
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2004: Wan Yongqin; Hur Wooyoung; Cho Charles Y; Liu Yi; Adrian Francisco J; Lozach Olivier; Bach Stéphane; Mayer Thomas; Fabbro Doriano; Meijer Laurent; Gray Nathanael S
Synthesis and target identification of hymenialdisine analogs.
Chemistry & biology 2004;11(2):247-59.
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2004: Erdogan-Orhan Ilkay; Sener Bilge; de Rosa Salvatore; Perez-Baz Julia; Lozach Olivier; Leost Maryse; Rakhilin Sergei; Meijer Laurent
Polyprenyl-hydroquinones and -furans from three marine sponges inhibit the cell cycle regulating phosphatase CDC25A.
Natural product research 2004;18(1):1-9.
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2004: Polychronopoulos Panagiotis; Magiatis Prokopios; Skaltsounis Alexios-Leandros; Myrianthopoulos Vassilios; Mikros Emmanuel; Tarricone Aldo; Musacchio Andrea; Roe S Mark; Pearl Laurence; Leost Maryse; Greengard Paul; Meijer Laurent
Structural basis for the synthesis of indirubins as potent and selective inhibitors of glycogen synthase kinase-3 and cyclin-dependent kinases.
Journal of medicinal chemistry 2004;47(4):935-46.
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2004: Sato Noboru; Meijer Laurent; Skaltsounis Leandros; Greengard Paul; Brivanlou Ali H
Maintenance of pluripotency in human and mouse embryonic stem cells through activation of Wnt signaling by a pharmacological GSK-3-specific inhibitor.
Nature medicine 2004;10(1):55-63.
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2004: Kunick Conrad; Lauenroth Kathrin; Leost Maryse; Meijer Laurent; Lemcke Thomas
1-Azakenpaullone is a selective inhibitor of glycogen synthase kinase-3 beta.
Bioorganic & medicinal chemistry letters 2004;14(2):413-6.
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2004: Kunick Conrad; Lauenroth Kathrin; Wieking Karen; Xie Xu; Schultz Christiane; Gussio Rick; Zaharevitz Daniel; Leost Maryse; Meijer Laurent; Weber Alexander; Jørgensen Flemming S; Lemcke Thomas
Evaluation and comparison of 3D-QSAR CoMSIA models for CDK1, CDK5, and GSK-3 inhibition by paullones.
Journal of medicinal chemistry 2004;47(1):22-36.
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2003: Meijer Laurent; Skaltsounis Alexios-Leandros; Magiatis Prokopios; Polychronopoulos Panagiotis; Knockaert Marie; Leost Maryse; Ryan Xiaozhou P; Vonica Claudia Alin; Brivanlou Ali; Dajani Rana; Crovace Claudia; Tarricone Cataldo; Musacchio Andrea; Roe S Mark; Pearl Laurence; Greengard Paul
GSK-3-selective inhibitors derived from Tyrian purple indirubins.
Chemistry & biology 2003;10(12):1255-66.
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2003: Bach Stéphane; Talarek Nicolas; Andrieu Thibault; Vierfond Jean-Michel; Mettey Yvette; Galons Hervé; Dormont Dominique; Meijer Laurent; Cullin Christophe; Blondel Marc
Isolation of drugs active against mammalian prions using a yeast-based screening assay.
Nature biotechnology 2003;21(9):1075-81.
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2003: Brachwitz Kristin; Voigt Burkhardt; Meijer Laurent; Lozach Olivier; Schächtele Christoph; Molnár Josef; Hilgeroth Andreas
Evaluation of the first cytostatically active 1-aza-9-oxafluorenes as novel selective CDK1 inhibitors with P-glycoprotein modulating properties.
Journal of medicinal chemistry 2003;46(5):876-9.
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2003: Mettey Yvette; Gompel Marie; Thomas Virginie; Garnier Matthieu; Leost Maryse; Ceballos-Picot Irène; Noble Martin; Endicott Jane; Vierfond Jean-michel; Meijer Laurent
Aloisines, a new family of CDK/GSK-3 inhibitors. SAR study, crystal structure in complex with CDK2, enzyme selectivity, and cellular effects.
Journal of medicinal chemistry 2003;46(2):222-36.
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2002: Knockaert Marie; Lenormand Philippe; Gray Nathanael; Schultz Peter; Pouysségur Jacques; Meijer Laurent
p42/p44 MAPKs are intracellular targets of the CDK inhibitor purvalanol.
Oncogene 2002;21(42):6413-24.
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2002: Doerig Christian; Meijer Laurent; Mottram Jeremy C
Protein kinases as drug targets in parasitic protozoa.
Trends in parasitology 2002;18(8):366-71.
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2002: Wieking Karen; Knockaert Marie; Leost Maryse; Zaharevitz Daniel W; Meijer Laurent; Kunick Conrad
Synthesis of paullones with aminoalkyl side chains.
Archiv der Pharmazie 2002;335(7):311-7.
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2002: Knockaert Marie; Wieking Karen; Schmitt Sophie; Leost Maryse; Grant Karen M; Mottram Jeremy C; Kunick Conrad; Meijer Laurent
Intracellular Targets of Paullones. Identification following affinity purification on immobilized inhibitor.
The Journal of biological chemistry 2002;277(28):25493-501.
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2002: Vogel Lee; Baratte Blandine; Détivaud Lénaïck; Azzi Lyamine; Leopold Pierre; Meijer Laurent
Molecular cloning and characterisation of p15(CDK-BP), a novel CDK-binding protein.
Biochimica et biophysica acta 2002;1589(2):219-31.
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2001: Loukaci A; Le Saout I; Samadi M; Leclerc S; Damiens E; Meijer L; Debitus C; Guyot M
Coscinosulfate, a CDC25 phosphatase inhibitor from the sponge Coscinoderma mathewsi.
Bioorganic & medicinal chemistry 2001;9(11):3049-54.
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2001: Damiens E; Baratte B; Marie D; Eisenbrand G; Meijer L
Anti-mitotic properties of indirubin-3'-monoxime, a CDK/GSK-3 inhibitor: induction of endoreplication following prophase arrest.
Oncogene 2001;20(29):3786-97.
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2001: Davies T G; Tunnah P; Meijer L; Marko D; Eisenbrand G; Endicott J A; Noble M E
Inhibitor binding to active and inactive CDK2: the crystal structure of CDK2-cyclin A/indirubin-5-sulphonate.
Structure (London, England : 1993) 2001;9(5):389-97.
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2001: Dorin D; Le Roch K; Sallicandro P; Alano P; Parzy D; Poullet P; Meijer L; Doerig C
Pfnek-1, a NIMA-related kinase from the human malaria parasite Plasmodium falciparum Biochemical properties and possible involvement in MAPK regulation.
European journal of biochemistry / FEBS 2001;268(9):2600-8.
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2001: Meijer L; Knockaert M; Damiens E
[Prevention of chemotherapy-induced alopecia by cyclin-dependant kinase inhibitors]
Bulletin du cancer 2001;88(4):347-50.
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2001: Marko D; Schätzle S; Friedel A; Genzlinger A; Zankl H; Meijer L; Eisenbrand G
Inhibition of cyclin-dependent kinase 1 (CDK1) by indirubin derivatives in human tumour cells.
British journal of cancer 2001;84(2):283-9.
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2001: Leclerc S; Garnier M; Hoessel R; Marko D; Bibb J A; Snyder G L; Greengard P; Biernat J; Wu Y Z; Mandelkow E M; Eisenbrand G; Meijer L
Indirubins inhibit glycogen synthase kinase-3 beta and CDK5/p25, two protein kinases involved in abnormal tau phosphorylation in Alzheimer's disease. A property common to most cyclin-dependent kinase inhibitors?
The Journal of biological chemistry 2001;276(1):251-60.
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2000: Primot A; Baratte B; Gompel M; Borgne A; Liabeuf S; Romette J L; Jho E H; Costantini F; Meijer L
Purification of GSK-3 by affinity chromatography on immobilized axin.
Protein expression and purification 2000;20(3):394-404.
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2000: Leost M; Schultz C; Link A; Wu Y Z; Biernat J; Mandelkow E M; Bibb J A; Snyder G L; Greengard P; Zaharevitz D W; Gussio R; Senderowicz A M; Sausville E A; Kunick C; Meijer L
Paullones are potent inhibitors of glycogen synthase kinase-3beta and cyclin-dependent kinase 5/p25.
European journal of biochemistry / FEBS 2000;267(19):5983-94.
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2000: Knockaert M; Gray N; Damiens E; Chang Y T; Grellier P; Grant K; Fergusson D; Mottram J; Soete M; Dubremetz J F; Le Roch K; Doerig C; Schultz P; Meijer L
Intracellular targets of cyclin-dependent kinase inhibitors: identification by affinity chromatography using immobilised inhibitors.
Chemistry & biology 2000;7(6):411-22.
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2000: Legraverend M; Tunnah P; Noble M; Ducrot P; Ludwig O; Grierson D S; Leost M; Meijer L; Endicott J
Cyclin-dependent kinase inhibition by new C-2 alkynylated purine derivatives and molecular structure of a CDK2-inhibitor complex.
Journal of medicinal chemistry 2000;43(7):1282-92.
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2000: Kunick C; Schultz C; Lemcke T; Zaharevitz D W; Gussio R; Jalluri R K; Sausville E A; Leost M; Meijer L
2-Substituted paullones: CDK1/cyclin B-inhibiting property and in vitro antiproliferative activity.
Bioorganic & medicinal chemistry letters 2000;10(6):567-9.
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2000: Le Roch K; Sestier C; Dorin D; Waters N; Kappes B; Chakrabarti D; Meijer L; Doerig C
Activation of a Plasmodium falciparum cdc2-related kinase by heterologous p25 and cyclin H. Functional characterization of a P. falciparum cyclin homologue.
The Journal of biological chemistry 2000;275(12):8952-8.
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2000: Gussio R; Zaharevitz D W; McGrath C F; Pattabiraman N; Kellogg G E; Schultz C; Link A; Kunick C; Leost M; Meijer L; Sausville E A
Structure-based design modifications of the paullone molecular scaffold for cyclin-dependent kinase inhibition.
Anti-cancer drug design 2000;15(1):53-66.
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1999: Bibb J A; Snyder G L; Nishi A; Yan Z; Meijer L; Fienberg A A; Tsai L H; Kwon Y T; Girault J A; Czernik A J; Huganir R L; Hemmings H C; Nairn A C; Greengard P
Phosphorylation of DARPP-32 by Cdk5 modulates dopamine signalling in neurons.
Nature 1999;402(6762):669-71.
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1999: Gray N; Détivaud L; Doerig C; Meijer L
ATP-site directed inhibitors of cyclin-dependent kinases.
Current medicinal chemistry 1999;6(9):859-75.
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1999: Détivaud L; Pettit G R; Meijer L
Characterization of a novel cdk1-related kinase.
European journal of biochemistry / FEBS 1999;264(1):55-66.
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1999: Legraverend M; Ludwig O; Bisagni E; Leclerc S; Meijer L; Giocanti N; Sadri R; Favaudon V
Synthesis and in vitro evaluation of novel 2,6,9-trisubstituted purines acting as cyclin-dependent kinase inhibitors.
Bioorganic & medicinal chemistry 1999;7(7):1281-93.
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1999: Schultz C; Link A; Leost M; Zaharevitz D W; Gussio R; Sausville E A; Meijer L; Kunick C
Paullones, a series of cyclin-dependent kinase inhibitors: synthesis, evaluation of CDK1/cyclin B inhibition, and in vitro antitumor activity.
Journal of medicinal chemistry 1999;42(15):2909-19.
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1999: Zaharevitz D W; Gussio R; Leost M; Senderowicz A M; Lahusen T; Kunick C; Meijer L; Sausville E A
Discovery and initial characterization of the paullones, a novel class of small-molecule inhibitors of cyclin-dependent kinases.
Cancer research 1999;59(11):2566-9.
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1999: Hoessel R; Leclerc S; Endicott J A; Nobel M E; Lawrie A; Tunnah P; Leost M; Damiens E; Marie D; Marko D; Niederberger E; Tang W; Eisenbrand G; Meijer L
Indirubin, the active constituent of a Chinese antileukaemia medicine, inhibits cyclin-dependent kinases.
Nature cell biology 1999;1(1):60-7.
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1999: Sausville E A; Zaharevitz D; Gussio R; Meijer L; Louarn-Leost M; Kunick C; Schultz R; Lahusen T; Headlee D; Stinson S; Arbuck S G; Senderowicz A
Cyclin-dependent kinases: initial approaches to exploit a novel therapeutic target.
Pharmacology & therapeutics 1999;82(2-3):285-92.
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1999: Meijer L; Leclerc S; Leost M
Properties and potential-applications of chemical inhibitors of cyclin-dependent kinases.
Pharmacology & therapeutics 1999;82(2-3):279-84.
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1999: Borgne A; Ostvold A C; Flament S; Meijer L
Intra-M phase-promoting factor phosphorylation of cyclin B at the prophase/metaphase transition.
The Journal of biological chemistry 1999;274(17):11977-86.
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1999: Giocanti N; Sadri R; Legraverend M; Ludwig O; Bisagni E; Leclerc S; Meijer L; Favaudon V
In vitro evaluation of a novel 2,6,9-trisubstituted purine acting as a cyclin-dependent kinase inhibitor.
Annals of the New York Academy of Sciences 1999;886():180-2.
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1998: Legraverend M; Ludwig O; Bisagni E; Leclerc S; Meijer L
Synthesis of C2 alkynylated purines, a new family of potent inhibitors of cyclin-dependent kinases.
Bioorganic & medicinal chemistry letters 1998;8(7):793-8.
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1997: Meijer L; Kim S H
Chemical inhibitors of cyclin-dependent kinases.
Methods in enzymology 1997;283():113-28.
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1996: Borgne A; Meijer L
Sequential dephosphorylation of p34(cdc2) on Thr-14 and Tyr-15 at the prophase/metaphase transition.
The Journal of biological chemistry 1996;271(44):27847-54.
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1995: Schulze-Gahmen U; Brandsen J; Jones H D; Morgan D O; Meijer L; Vesely J; Kim S H
Multiple modes of ligand recognition: crystal structures of cyclin-dependent protein kinase 2 in complex with ATP and two inhibitors, olomoucine and isopentenyladenine.
Proteins 1995;22(4):378-91.
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1995: Meijer L
Chemical inhibitors of cyclin-dependent kinases.
Progress in cell cycle research 1995;1():351-63.
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1994: Azzi L; Meijer L; Ostvold A C; Lew J; Wang J H
Purification of a 15-kDa cdk4- and cdk5-binding protein.
The Journal of biological chemistry 1994;269(18):13279-88.
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1992: Baratte B; Meijer L; Galaktionov K; Beach D
Screening for antimitotic compounds using the cdc25 tyrosine phosphatase, an activator of the mitosis-inducing p34cdc2/cyclin Bcdc13 protein kinase.
Anticancer research 1992;12(3):873-80.
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1992: Azzi L; Meijer L; Reed S I; Pidikiti R; Tung H Y
Interaction between the cell-cycle-control proteins p34cdc2 and p9CKShs2. Evidence for two cooperative binding domains in p9CKShs2.
European journal of biochemistry / FEBS 1992;203(3):353-60.
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1991: Meijer L; Azzi L; Wang J Y
Cyclin B targets p34cdc2 for tyrosine phosphorylation.
The EMBO journal 1991;10(6):1545-54.
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1991: Meijer L; Ostvold A C; Walass S I; Lund T; Laland S G
High-mobility-group proteins P1, I and Y as substrates of the M-phase-specific p34cdc2/cyclincdc13 kinase.
European journal of biochemistry / FEBS 1991;196(3):557-67.
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1991: Meijer L; Arion D
Negative control of cdc2 kinase activation by cAMP in starfish oocytes.
Cold Spring Harbor symposia on quantitative biology 1991;56():591-8.
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1990: Pondaven P; Meijer L; Beach D
Activation of M-phase-specific histone H1 kinase by modification of the phosphorylation of its p34cdc2 and cyclin components.
Genes & development 1990;4(1):9-17.
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1989: Meijer L; Arion D; Golsteyn R; Pines J; Brizuela L; Hunt T; Beach D
Cyclin is a component of the sea urchin egg M-phase specific histone H1 kinase.
The EMBO journal 1989;8(8):2275-82.
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1989: Arion D; Meijer L
M-phase-specific protein kinase from mitotic sea urchin eggs: cyclic activation depends on protein synthesis and phosphorylation but does not require DNA or RNA synthesis.
Experimental cell research 1989;183(2):361-75.
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1989: Meijer L; Dostmann W; Genieser H G; Butt E; Jastorff B
Starfish oocyte maturation: evidence for a cyclic AMP-dependent inhibitory pathway.
Developmental biology 1989;133(1):58-66.
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1988: Arion D; Meijer L; Brizuela L; Beach D
cdc2 is a component of the M phase-specific histone H1 kinase: evidence for identity with MPF.
Cell 1988;55(2):371-8.
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1988: Meijer L; Pondaven P
Cyclic activation of histone H1 kinase during sea urchin egg mitotic divisions.
Experimental cell research 1988;174(1):116-29.
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1987: Meijer L; Pelech S L; Krebs E G
Differential regulation of histone H1 and ribosomal S6 kinases during sea star oocyte maturation.
Biochemistry 1987;26(24):7968-74.
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1987: Pelech S L; Meijer L; Krebs E G
Characterization of maturation-activated histone H1 and ribosomal S6 kinases in sea star oocytes.
Biochemistry 1987;26(24):7960-8.
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1986: Meijer L; Pondaven P; Tung H Y; Cohen P; Wallace R W
Protein phosphorylation and oocyte maturation. II. Inhibition of starfish oocyte maturation by intracellular microinjection of protein phosphatases 1 and 2A and alkaline phosphatase.
Experimental cell research 1986;163(2):489-99.
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1986: Pondaven P; Meijer L
Protein phosphorylation and oocyte maturation. I. Induction of starfish oocyte maturation by intracellular microinjection of a phosphatase inhibitor, alpha-naphthylphosphate.
Experimental cell research 1986;163(2):477-88.
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