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Peter Meinke

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TOP 3
Libo Xu; Christine McCallum; Peter T Meinke; James F Dropinski; Amy K Farthing; Emily Hickey; Kun Liu
Synthesis and antibacterial activity of novel water-soluble nocathiacin analogs.
Yejun Tan; G Marie Thompson; John R Thompson; Kenny K Wong; Harold B Wood; Hongyue Dai; Pek Yee Lum; Peter T Meinke; Eric S Muise; Richard Raubertas; Joel P Berger
Novel transcriptome profiling analyses demonstrate that selective peroxisome proliferator-activated receptor γ (PPARγ) modulators display attenuated and selective gene regulatory activity in comparison with PPARγ full agonists.
Weiguo Liu; Kun Liu; Harold B Wood; Margaret E McCann; Thomas W Doebber; Ching H Chang; Taro E Akiyama; Monica Einstein; Joel P Berger; Peter T Meinke
Discovery of a peroxisome proliferator activated receptor gamma (PPARgamma) modulator with balanced PPARalpha activity for the treatment of type 2 diabetes and dyslipidemia.

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All Publications

2013: Libo Xu; Christine McCallum; Peter T Meinke; James F Dropinski; Amy K Farthing; Emily Hickey; Kun Liu
Synthesis and antibacterial activity of novel water-soluble nocathiacin analogs.
Bioorganic & medicinal chemistry letters 2013;23(1):366-9.
2012: Yejun Tan; G Marie Thompson; John R Thompson; Kenny K Wong; Harold B Wood; Hongyue Dai; Pek Yee Lum; Peter T Meinke; Eric S Muise; Richard Raubertas; Joel P Berger
Novel transcriptome profiling analyses demonstrate that selective peroxisome proliferator-activated receptor γ (PPARγ) modulators display attenuated and selective gene regulatory activity in comparison with PPARγ full agonists.
Molecular pharmacology 2012;82(1):68-79.
2009: Weiguo Liu; Kun Liu; Harold B Wood; Margaret E McCann; Thomas W Doebber; Ching H Chang; Taro E Akiyama; Monica Einstein; Joel P Berger; Peter T Meinke
Discovery of a peroxisome proliferator activated receptor gamma (PPARgamma) modulator with balanced PPARalpha activity for the treatment of type 2 diabetes and dyslipidemia.
Journal of medicinal chemistry 2009;52(14):4443-53.
2009: John J Acton; Taro E Akiyama; Ching H Chang; Lawrence F Colwell; Sheryl D Debenham; Thomas W Doebber; Monica Einstein; Kun Liu; Margaret E McCann; David E Moller; Eric S Muise; Yugen Tan; John Ryan Thompson; Kenny K Wong; Margaret Wu; Libo Xu; Peter T Meinke; Joel P Berger; Harold B Wood
Discovery of (2R)-2-(3-{3-[(4-Methoxyphenyl)carbonyl]-2-methyl-6-(trifluoromethoxy)-1H-indol-1-yl}phenoxy)butanoic acid (MK-0533): a novel selective peroxisome proliferator-activated receptor gamma modulator for the treatment of type 2 diabetes mellitus with a reduced potential to increase plasma and extracellular fluid volume.
Journal of medicinal chemistry 2009;52(13):3846-54.
2009: Libo Xu; Amy K Farthing; James F Dropinski; Peter T Meinke; Christine McCallum; Penny Sue Leavitt; Emily J Hickey; Lawrence F Colwell; John Barrett; Kun Liu
Nocathiacin analogs: Synthesis and antibacterial activity of novel water-soluble amides.
Bioorganic & medicinal chemistry letters 2009;19(13):3531-5.
2009: Peter T Meinke; Steven L Colletti; Michael H Fisher; Matthew J Wyvratt; Thomas L Shih; Michelle B Ayer; Chunshi Li; J Lim; Dong Ok; Steve Salva; Lynn M Warmke; Michelle Zakson; BF Michael; Pierre Demontigny; DA Ostlind; David Fink; Marlene Drag; Dennis M Schmatz; Wesley L Shoop
Discovery of the development candidate N-tert-butyl nodulisporamide: a safe and efficacious once monthly oral agent for the control of fleas and ticks on companion animals.
Journal of medicinal chemistry 2009;52(11):3505-15.
2008: Sheryl D Debenham; Audrey Chan; Fiona Waiyu Lau; Weiguo Liu; Harold B Wood; Karen Lemme; Lawrence F Colwell; Bahanu Habulihaz; Taro E Akiyama; Monica Einstein; Thomas W Doebber; Neelam Sharma; Chuanlin F Wang; Margaret Wu; Joel P Berger; Peter T Meinke
Highly functionalized 7-azaindoles as selective PPAR gamma modulators.
Bioorganic & medicinal chemistry letters 2008;18(17):4798-801.
2008: Ching H Chang; Lesley A McNamara; Margaret S Wu; Eric S Muise; Yejun Tan; Harold B Wood; Peter T Meinke; John Ryan Thompson; Thomas W Doebber; Joel P Berger; Margaret E McCann
A novel selective peroxisome proliferator-activator receptor-gamma modulator-SPPARgammaM5 improves insulin sensitivity with diminished adverse cardiovascular effects.
European journal of pharmacology 2008;584(1):192-201.
2008: Joey L Methot; Prasun K Chakravarty; Melissa Chenard; Joshua Close; Cruz Jonathan; William K Dahlberg; Judith Fleming; Christopher L Hamblett; Julie E Hamill; Paul Harrington; Andreas Harsch; Richard Heidebrecht; Bethany Hughes; Joon Jung; Candia M Kenific; Astrid M Kral; Peter T Meinke; Richard E Middleton; Nicole Ozerova; David L Sloman; Matthew G Stanton; Alexander A Szewczak; Sriram Tyagarajan; David J Witter; J Paul Secrist; Thomas A Miller
Exploration of the internal cavity of histone deacetylase (HDAC) with selective HDAC1/HDAC2 inhibitors (SHI-1:2).
Bioorganic & medicinal chemistry letters 2008;18(3):973-8.
2008: Monica Einstein; Taro E Akiyama; Gino A Castriota; Chuanlin F Wang; Brian McKeever; Ralph T Mosley; Joseph W Becker; David E Moller; Peter T Meinke; Harold B Wood; Joel P Berger
The differential interactions of peroxisome proliferator-activated receptor gamma ligands with Tyr473 is a physical basis for their unique biological activities.
Molecular pharmacology 2008;73(1):62-74.
2007: Libo Xu; Amy K Farthing; Yao-Jun Shi; Peter T Meinke; Kun Liu
Conversion of nocathiacin I to nocathiacin acid by a mild and selective cleavage of dehydroalanine.
The Journal of organic chemistry 2007;72(19):7447-50.
2006: Philip Jones; Sergio Altamura; Prasun K Chakravarty; Ottavia Cecchetti; Raffaele De Francesco; paola gallinari; Raffaele Ingenito; Peter T Meinke; Alessia Petrocchi; Michael Rowley; Rita Scarpelli; Sergio Serafini; Christian Steinkühler
A series of novel, potent, and selective histone deacetylase inhibitors.
Bioorganic & medicinal chemistry letters 2006;16(23):5948-52.
2006: Ranjit C Desai; Edward Metzger; Conrad Santini; Peter T Meinke; James V Heck; Joel P Berger; Karen L Macnaul; Tian-Quan Cai; Samuel D Wright; Arun Agrawal; David E Moller; Soumya P Sahoo
Design and synthesis of potent and subtype-selective PPARalpha agonists.
Bioorganic & medicinal chemistry letters 2006;16(6):1673-8.
2005: James F Dropinski; Taro Akiyama; Monica Einstein; Bahanu Habulihaz; Thomas W Doebber; Joel P Berger; Peter T Meinke; Guo Q Shi
Synthesis and biological activities of novel aryl indole-2-carboxylic acid analogs as PPARgamma partial agonists.
Bioorganic & medicinal chemistry letters 2005;15(22):5035-8.
2005: Guo Q Shi; James F Dropinski; Yong Zhang; Conrad Santini; Soumya P Sahoo; Joel P Berger; Karen L Macnaul; Gaochao Zhou; Arun Agrawal; Raul Alvaro; Tian-Quan Cai; Melba Hernandez; Samuel D Wright; David E Moller; James V Heck; Peter T Meinke
Novel 2,3-dihydrobenzofuran-2-carboxylic acids: highly potent and subtype-selective PPARalpha agonists with potent hypolipidemic activity.
Journal of medicinal chemistry 2005;48(17):5589-99.
2005: Jun Liang; Richard Brochu; charles cohen; Ivy E Dick; John P Felix; Michael H Fisher; Maria L Garcia; Gregory J Kaczorowski; Kathryn A Lyons; Peter T Meinke; Birgit T Priest; william Schmalhofer; McHardy Smith; Jason W Tarpley; Brande S Williams; William J Martin; William H Parsons
Discovery of potent and use-dependent sodium channel blockers for treatment of chronic pain.
Bioorganic & medicinal chemistry letters 2005;15(11):2943-7.
2005: Kun Liu; Regina M Black; John J Acton; Ralph T Mosley; Sheryl Debenham; Ramon Abola; Meng Yang; Richard A Tschirret-Guth; Lawrence F Colwell; Cherrie Liu; Margaret Wu; Chuanlin F Wang; Karen L Macnaul; Margaret E McCann; David E Moller; Joel P Berger; Peter T Meinke; A Brian Jones; Harold B Wood
Selective PPARgamma modulators with improved pharmacological profiles.
Bioorganic & medicinal chemistry letters 2005;15(10):2437-40.
2005: Joel P Berger; Taro E Akiyama; Peter T Meinke
PPARs: therapeutic targets for metabolic disease.
Trends in pharmacological sciences 2005;26(5):244-51.
2005: Pengcheng P Shao; Dong Ok; Michael H Fisher; Maria L Garcia; Gregory J Kaczorowski; Chunshi Li; Kathryn A Lyons; William J Martin; Peter T Meinke; Birgit T Priest; McHardy Smith; Matthew J Wyvratt; Feng Ye; William H Parsons
Novel cyclopentane dicarboxamide sodium channel blockers as a potential treatment for chronic pain.
Bioorganic & medicinal chemistry letters 2005;15(7):1901-7.
2005: Taro E Akiyama; Peter T Meinke; Joel P Berger
PPAR ligands: potential therapies for metabolic syndrome.
Current diabetes reports 2005;5(1):45-52.
2004: Birgit T Priest; Maria L Garcia; Richard E Middleton; Richard Brochu; Samantha Clark; Ge Dai; Ivy E Dick; John P Felix; Chou J Liu; Brita S Reiseter; william Schmalhofer; Pengcheng P Shao; Yui S Tang; Margaret Z Chou; Martin G Kohler; McHardy Smith; Vivien A Warren; Brande S Williams; charles cohen; William J Martin; Peter T Meinke; William H Parsons; Keith A Wafford; Gregory J Kaczorowski
A disubstituted succinamide is a potent sodium channel blocker with efficacy in a rat pain model.
Biochemistry 2004;43(30):9866-76.
2003: Jisong Cui; Li Huang; Annie Zhao; Jane-L Lew; Jinghua Yu; Soumya Sahoo; Peter T Meinke; Inmaculada Royo; Fernando Pelaez; Samuel D Wright
Guggulsterone is a farnesoid X receptor antagonist in coactivator association assays but acts to enhance transcription of bile salt export pump.
The Journal of biological chemistry 2003;278(12):10214-20.
2003: Prasun K Chakravarty; Thomas L Shih; Steven L Colletti; Michelle B Ayer; Christine Snedden; Howard Kuo; Sriram Tyagarajan; Lynn Gregory; Michelle Zakson-Aiken; Wesley L Shoop; Dennis M Schmatz; Matthew J Wyvratt; Michael H Fisher; Peter T Meinke
Nodulisporic acid side-chain modifications: access to the 2", 3", 4", and 6" registers.
Bioorganic & medicinal chemistry letters 2003;13(1):147-50.
2002: Jinghua Yu; Jane-L Lo; Li Huang; Annie Zhao; Edward Metzger; Alan Adams; Peter T Meinke; Samuel D Wright; Jisong Cui
Lithocholic acid decreases expression of bile salt export pump through farnesoid X receptor antagonist activity.
The Journal of biological chemistry 2002;277(35):31441-7.
2002: Dong Ok; Chunshi Li; Thomas L Shih; Steve Salva; Michelle B Ayer; Steven L Colletti; Prasun K Chakravarty; Matthew J Wyvratt; Michael H Fisher; Lynn Gregory; Michelle Zakson-Aiken; Wesley L Shoop; Dennis M Schmatz; Peter T Meinke
Side-chain homologation of nodulisporic acid: synthesis of potent new dienyl derivatives.
Bioorganic & medicinal chemistry letters 2002;12(13):1751-4.
2002: Peter T Meinke; McHardy Smith; Wesley L Shoop
Nodulisporic acid: its chemistry and biology.
Current topics in medicinal chemistry 2002;2(7):655-74.
2002: Steven W Ludmerer; Vivien A Warren; Brande S Williams; Yingcong Zheng; David C Hunt; Michelle B Ayer; Michael A Wallace; Ashok G Chaudhary; Marjorie A Egan; Peter T Meinke; Dennis C Dean; Maria L Garcia; Doris F Cully; McHardy Smith
Ivermectin and nodulisporic acid receptors in Drosophila melanogaster contain both gamma-aminobutyric acid-gated Rdl and glutamate-gated GluCl alpha chloride channel subunits.
Biochemistry 2002;41(20):6548-60.
2002: Prasun K Chakravarty; Sriram Tyagarajan; Thomas L Shih; Steve Salva; Christine Snedden; Matthew J Wyvratt; Michael H Fisher; Peter T Meinke
Synthesis of side chain truncated 3"-aldehyde, 3"-carboxylic acid, and 1"-aldehyde from nodulisporic acid A.
Organic letters 2002;4(8):1291-4.
2002: Tom Felcetto; John G Ondeyka; Steven L Colletti; Peter T Meinke; Wesley L Shoop
Comparison of nodulisporic acid analogs in a Lucilia sericata in vitro assay and a Ctenocephalides felis membrane feeding system.
The Journal of parasitology 2002;88(2):223-6.
2001: R Berger; Wesley L Shoop; James V Pivnichny; L M Warmke; Michelle Zakson-Aiken; K A Owens; P deMontigny; Dennis M Schmatz; Matthew J Wyvratt; Michael H Fisher; Peter T Meinke; Steven L Colletti
Synthesis of nodulisporic acid 2' '-oxazoles and 2' '-thiazoles.
Organic letters 2001;3(23):3715-8.
2001: Wesley L Shoop; Michelle Zakson-Aiken; Lynn Gregory; BF Michael; James V Pivnichny; Peter T Meinke; Michael H Fisher; Matthew J Wyvratt; B Pikounis; Dennis M Schmatz
Systemic efficacy of nodulisporamides against fleas on dogs.
The Journal of parasitology 2001;87(5):1150-4.
2001: Michelle Zakson-Aiken; Lynn Gregory; Peter T Meinke; Wesley L Shoop
Systemic activity of the avermectins against the cat flea (Siphonaptera: Pulicidae).
Journal of medical entomology 2001;38(4):576-80.
2001: Wesley L Shoop; Lynn Gregory; Michelle Zakson-Aiken; BF Michael; H W Haines; John G Ondeyka; Peter T Meinke; Dennis M Schmatz
Systemic efficacy of nodulisporic acid against fleas on dogs.
The Journal of parasitology 2001;87(2):419-23.
2001: Peter T Meinke
Perspectives in animal health: old targets and new opportunities.
Journal of medicinal chemistry 2001;44(5):641-59.
2001: Peter T Meinke; Paul A Liberator
Histone deacetylase: a target for antiproliferative and antiprotozoal agents.
Current medicinal chemistry 2001;8(2):211-35.
2001: Steven L Colletti; RW Myers; Sandra J Darkin-Rattray; Anne Gurnett; Paula M Dulski; S Galuska; John Allocco; Michelle B Ayer; Chunshi Li; J Lim; Tami Crumley; C Cannova; Dennis M Schmatz; Matthew J Wyvratt; Michael H Fisher; Peter T Meinke
Broad spectrum antiprotozoal agents that inhibit histone deacetylase: structure-activity relationships of apicidin. Part 2.
Bioorganic & medicinal chemistry letters 2001;11(2):113-7.
2001: Steven L Colletti; RW Myers; Sandra J Darkin-Rattray; Anne Gurnett; Paula M Dulski; S Galuska; John Allocco; Michelle B Ayer; Chunshi Li; J Lim; Tami Crumley; C Cannova; Dennis M Schmatz; Matthew J Wyvratt; Michael H Fisher; Peter T Meinke
Broad spectrum antiprotozoal agents that inhibit histone deacetylase: structure-activity relationships of apicidin. Part 1.
Bioorganic & medicinal chemistry letters 2001;11(2):107-11.
2000: Peter T Meinke; Steven L Colletti; G Doss; RW Myers; Anne Gurnett; Paula M Dulski; Sandra J Darkin-Rattray; John Allocco; S Galuska; Dennis M Schmatz; Matthew J Wyvratt; Michael H Fisher
Synthesis of apicidin-derived quinolone derivatives: parasite-selective histone deacetylase inhibitors and antiproliferative agents.
Journal of medicinal chemistry 2000;43(25):4919-22.
2000: Gerard R Dawson; Keith A Wafford; A Smith; G R Marshall; Peter J Bayley; J M Schaeffer; Peter T Meinke; Ruth M McKernan
Anticonvulsant and adverse effects of avermectin analogs in mice are mediated through the gamma-aminobutyric acid(A) receptor.
The Journal of pharmacology and experimental therapeutics 2000;295(3):1051-60.
2000: Peter T Meinke; Michelle B Ayer; Steven L Colletti; Chunshi Li; J Lim; Dong Ok; Steve Salva; Dennis M Schmatz; Thomas L Shih; Wesley L Shoop; L M Warmke; Matthew J Wyvratt; Michelle Zakson-Aiken; Michael H Fisher
Chemical modification of nodulisporic acid A: preliminary structure-activity relationships.
Bioorganic & medicinal chemistry letters 2000;10(20):2371-4.
2000: McHardy Smith; Vivien A Warren; B S Thomas; Richard Brochu; E A Ertel; S Rohrer; J Schaeffer; Dennis M Schmatz; B R Petuch; Yui S Tang; Peter T Meinke; Gregory J Kaczorowski; charles cohen
Nodulisporic acid opens insect glutamate-gated chloride channels: identification of a new high affinity modulator.
Biochemistry 2000;39(18):5543-54.
1998: Peter T Meinke; Wesley L Shoop; BF Michael; T A Blizzard; Gerard R Dawson; Michael H Fisher; H Mrozik
Synthesis of gem-difluoro-avermectin derivatives: potent anthelmintic and anticonvulsant agents.
Bioorganic & medicinal chemistry letters 1998;8(24):3643-6.