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John Mekalanos

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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TOP 3
Thanawastien Ann; Montor Wagner R; Labaer Joshua; Mekalanos John J; Yoon Sang Sun
Vibrio cholerae proteome-wide screen for immunostimulatory proteins identifies phosphatidylserine decarboxylase as a novel Toll-like receptor 4 agonist.
Ma Amy T; McAuley Steven; Pukatzki Stefan; Mekalanos John J
Translocation of a Vibrio cholerae type VI secretion effector requires bacterial endocytosis by host cells.
Leiman Petr G; Basler Marek; Ramagopal Udupi A; Bonanno Jeffrey B; Sauder J Michael; Pukatzki Stefan; Burley Stephen K; Almo Steven C; Mekalanos John J
Type VI secretion apparatus and phage tail-associated protein complexes share a common evolutionary origin.

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All Publications

2009: Thanawastien Ann; Montor Wagner R; Labaer Joshua; Mekalanos John J; Yoon Sang Sun
Vibrio cholerae proteome-wide screen for immunostimulatory proteins identifies phosphatidylserine decarboxylase as a novel Toll-like receptor 4 agonist.
PLoS pathogens 2009;5(8):e1000556.
2009: Ma Amy T; McAuley Steven; Pukatzki Stefan; Mekalanos John J
Translocation of a Vibrio cholerae type VI secretion effector requires bacterial endocytosis by host cells.
Cell host & microbe 2009;5(3):234-43.
2009: Leiman Petr G; Basler Marek; Ramagopal Udupi A; Bonanno Jeffrey B; Sauder J Michael; Pukatzki Stefan; Burley Stephen K; Almo Steven C; Mekalanos John J
Type VI secretion apparatus and phage tail-associated protein complexes share a common evolutionary origin.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(11):4154-9.
2008: Zahid M Shamim Hasan; Udden S M Nashir; Faruque A S G; Calderwood Stephen B; Mekalanos John J; Faruque Shah M
Effect of phage on the infectivity of Vibrio cholerae and emergence of genetic variants.
Infection and immunity 2008;76(11):5266-73.
2008: Rhie Gi-eun; Jung Hae-Mi; Kim Bong Su; Mekalanos John J
Construction of a Vibrio cholerae prototype vaccine strain O395-N1-E1 which accumulates cell-associated cholera toxin B subunit.
Vaccine 2008;26(43):5443-8.
2008: Udden S M Nashir; Zahid M Shamim Hasan; Biswas Kuntal; Ahmad Qazi Shafi; Cravioto Alejandro; Nair G Balakrish; Mekalanos John J; Faruque Shah M
Acquisition of classical CTX prophage from Vibrio cholerae O141 by El Tor strains aided by lytic phages and chitin-induced competence.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(33):11951-6.
2008: Rahman M Hasibur; Biswas Kuntal; Hossain M Anwar; Sack R Bradley; Mekalanos John J; Faruque Shah M
Distribution of genes for virulence and ecological fitness among diverse Vibrio cholerae population in a cholera endemic area: tracking the evolution of pathogenic strains.
DNA and cell biology 2008;27(7):347-55.
2008: Cameron D Ewen; Urbach Jonathan M; Mekalanos John J
A defined transposon mutant library and its use in identifying motility genes in Vibrio cholerae.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(25):8736-41.
2008: Yoon Sang Sun; Mekalanos John J
Decreased potency of the Vibrio cholerae sheathed flagellum to trigger host innate immunity.
Infection and immunity 2008;76(3):1282-8.
2008: Rhie Gi-Eun; Jung Hae-Mi; Park Jungchan; Kim Bong-Su; Mekalanos John J
Construction of cholera toxin B subunit-producing Vibrio cholerae strains using the Mariner-FRT transposon delivery system.
FEMS immunology and medical microbiology 2008;52(1):23-8.
2007: Shakhnovich Elizabeth A; Sturtevant Derek; Mekalanos John J
Molecular mechanisms of virstatin resistance by non-O1/non-O139 strains of Vibrio cholerae.
Molecular microbiology 2007;66(6):1331-41.
2007: Pukatzki Stefan; Ma Amy T; Revel Andrew T; Sturtevant Derek; Mekalanos John J
Type VI secretion system translocates a phage tail spike-like protein into target cells where it cross-links actin.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(39):15508-13.
2007: Mougous Joseph D; Gifford Casey A; Ramsdell Talia L; Mekalanos John J
Threonine phosphorylation post-translationally regulates protein secretion in Pseudomonas aeruginosa.
Nature cell biology 2007;9(7):797-803.
2007: Tam Vincent C; Serruto Davide; Dziejman Michelle; Brieher William; Mekalanos John J
A type III secretion system in Vibrio cholerae translocates a formin/spire hybrid-like actin nucleator to promote intestinal colonization.
Cell host & microbe 2007;1(2):95-107.
2007: Raskin David M; Judson Nicholas; Mekalanos John J
Regulation of the stringent response is the essential function of the conserved bacterial G protein CgtA in Vibrio cholerae.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(11):4636-41.
2007: Faruque Shah M; Tam Vincent C; Chowdhury Nityananda; Diraphat Pornphan; Dziejman Michelle; Heidelberg John F; Clemens John D; Mekalanos John J; Nair G Balakrish
Genomic analysis of the Mozambique strain of Vibrio cholerae O1 reveals the origin of El Tor strains carrying classical CTX prophage.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(12):5151-6.
2007: Smith Michael G; Gianoulis Tara A; Pukatzki Stefan; Mekalanos John J; Ornston L Nicholas; Gerstein Mark; Snyder Michael
New insights into Acinetobacter baumannii pathogenesis revealed by high-density pyrosequencing and transposon mutagenesis.
Genes & development 2007;21(5):601-14.
2007: Shakhnovich Elizabeth A; Hung Deborah T; Pierson Emily; Lee Kyungae; Mekalanos John J
Virstatin inhibits dimerization of the transcriptional activator ToxT.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(7):2372-7.
2007: Qadri Firdausi; Chowdhury Mohiul I; Faruque Shah M; Salam Mohammed A; Ahmed Tanvir; Begum Yasmin A; Saha Amit; Al Tarique Abdullah; Seidlein Lorenz V; Park Eunsik; Killeen Kevin P; Mekalanos John J; Clemens John D; Sack David A;
Peru-15, a live attenuated oral cholera vaccine, is safe and immunogenic in Bangladeshi toddlers and infants.
Vaccine 2007;25(2):231-8.
2006: Yoon Sang Sun; Mekalanos John J
2,3-butanediol synthesis and the emergence of the Vibrio cholerae El Tor biotype.
Infection and immunity 2006;74(12):6547-56.
2006: Bina James E; Provenzano Daniele; Wang Chunmei; Bina Xiaowen R; Mekalanos John J
Characterization of the Vibrio cholerae vexAB and vexCD efflux systems.
Archives of microbiology 2006;186(3):171-81.
2006: Mougous Joseph D; Cuff Marianne E; Raunser Stefan; Shen Aimee; Zhou Min; Gifford Casey A; Goodman Andrew L; Joachimiak Grazyna; Ordoñez Claudia L; Lory Stephen; Walz Thomas; Joachimiak Andrzej; Mekalanos John J
A virulence locus of Pseudomonas aeruginosa encodes a protein secretion apparatus.
Science (New York, N.Y.) 2006;312(5779):1526-30.
2006: Faruque Shah M; Biswas Kuntal; Udden S M Nashir; Ahmad Qazi Shafi; Sack David A; Nair G Balakrish; Mekalanos John J
Transmissibility of cholera: in vivo-formed biofilms and their relationship to infectivity and persistence in the environment.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(16):6350-5.
2006: Faruque Shah M; Islam M Johirul; Ahmad Qazi Shafi; Biswas Kuntal; Faruque A S G; Nair G Balakrish; Sack R Bradley; Sack David A; Mekalanos John J
An improved technique for isolation of environmental Vibrio cholerae with epidemic potential: monitoring the emergence of a multiple-antibiotic-resistant epidemic strain in Bangladesh.
The Journal of infectious diseases 2006;193(7):1029-36.
2006: Jensen Mark A; Faruque Shah M; Mekalanos John J; Levin Bruce R
Modeling the role of bacteriophage in the control of cholera outbreaks.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(12):4652-7.
2006: Raskin David M; Seshadri Rekha; Pukatzki Stefan U; Mekalanos John J
Bacterial genomics and pathogen evolution.
Cell 2006;124(4):703-14.
2006: Rietsch Arne; Mekalanos John J
Metabolic regulation of type III secretion gene expression in Pseudomonas aeruginosa.
Molecular microbiology 2006;59(3):807-20.
2006: Pukatzki Stefan; Ma Amy T; Sturtevant Derek; Krastins Bryan; Sarracino David; Nelson William C; Heidelberg John F; Mekalanos John J
Identification of a conserved bacterial protein secretion system in Vibrio cholerae using the Dictyostelium host model system.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(5):1528-33.
2006: Hung Deborah T; Zhu Jun; Sturtevant Derek; Mekalanos John J
Bile acids stimulate biofilm formation in Vibrio cholerae.
Molecular microbiology 2006;59(1):193-201.
2005: Hung Deborah T; Shakhnovich Elizabeth A; Pierson Emily; Mekalanos John J
Small-molecule inhibitor of Vibrio cholerae virulence and intestinal colonization.
Science (New York, N.Y.) 2005;310(5748):670-4.
2005: Larocque Regina C; Harris Jason B; Dziejman Michelle; Li Xiaoman; Khan Ashraful I; Faruque Abu S G; Faruque Shah M; Nair G B; Ryan Edward T; Qadri Firdausi; Mekalanos John J; Calderwood Stephen B
Transcriptional profiling of Vibrio cholerae recovered directly from patient specimens during early and late stages of human infection.
Infection and immunity 2005;73(8):4488-93.
2005: Qadri Firdausi; Chowdhury Mohiul I; Faruque Shah M; Salam Mohammed A; Ahmed Tanvir; Begum Yasmin A; Saha Amit; Alam Mohammed S; Zaman K; Seidlein Lorenz V; Park Eunsik; Killeen Kevin P; Mekalanos John J; Clemens John D; Sack David A;
Randomized, controlled study of the safety and immunogenicity of Peru-15, a live attenuated oral vaccine candidate for cholera, in adult volunteers in Bangladesh.
The Journal of infectious diseases 2005;192(4):573-9.
2005: Faruque Shah M; Bin Naser Iftekhar; Fujihara Kazutaka; Diraphat Pornphan; Chowdhury Nityananda; Kamruzzaman M; Qadri Firdausi; Yamasaki Shinji; Ghosh A N; Mekalanos John J
Genomic sequence and receptor for the Vibrio cholerae phage KSF-1phi: evolutionary divergence among filamentous vibriophages mediating lateral gene transfer.
Journal of bacteriology 2005;187(12):4095-103.
2005: Aulinger Benedikt A; Roehrl Michael H; Mekalanos John J; Collier R John; Wang Julia Y
Combining anthrax vaccine and therapy: a dominant-negative inhibitor of anthrax toxin is also a potent and safe immunogen for vaccines.
Infection and immunity 2005;73(6):3408-14.
2005: Rietsch Arne; Vallet-Gely Isabelle; Dove Simon L; Mekalanos John J
ExsE, a secreted regulator of type III secretion genes in Pseudomonas aeruginosa.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(22):8006-11.
2005: Faruque Shah M; Islam M Johirul; Ahmad Qazi Shafi; Faruque A S G; Sack David A; Nair G Balakrish; Mekalanos John J
Self-limiting nature of seasonal cholera epidemics: Role of host-mediated amplification of phage.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(17):6119-24.
2005: Vance Russell E; Rietsch Arne; Mekalanos John J
Role of the type III secreted exoenzymes S, T, and Y in systemic spread of Pseudomonas aeruginosa PAO1 in vivo.
Infection and immunity 2005;73(3):1706-13.
2005: Dziejman Michelle; Serruto Davide; Tam Vincent C; Sturtevant Derek; Diraphat Pornphan; Faruque Shah M; Rahman M Hasibur; Heidelberg John F; Decker Jeremy; Li Li; Montgomery Kate T; Grills George; Kucherlapati Raju; Mekalanos John J
Genomic characterization of non-O1, non-O139 Vibrio cholerae reveals genes for a type III secretion system.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(9):3465-70.
2005: Hung Deborah T; Mekalanos John J
Bile acids induce cholera toxin expression in Vibrio cholerae in a ToxT-independent manner.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(8):3028-33.
2005: Faruque Shah M; Naser Iftekhar Bin; Islam M Johirul; Faruque A S G; Ghosh A N; Nair G Balakrish; Sack David A; Mekalanos John J
Seasonal epidemics of cholera inversely correlate with the prevalence of environmental cholera phages.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(5):1702-7.
2004: Faruque Shah M; Nair G Balakrish; Mekalanos John J
Genetics of stress adaptation and virulence in toxigenic Vibrio cholerae.
DNA and cell biology 2004;23(11):723-41.
2004: Rietsch Arne; Wolfgang Matthew C; Mekalanos John J
Effect of metabolic imbalance on expression of type III secretion genes in Pseudomonas aeruginosa.
Infection and immunity 2004;72(3):1383-90.
2004: Jönsson Klas; Guo Betty P; Monstein Hans-Jürg; Mekalanos John J; Kronvall Göran
Molecular cloning and characterization of two Helicobacter pylori genes coding for plasminogen-binding proteins.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(7):1852-7.
2004: Vance Russell E; Hong Song; Gronert Karsten; Serhan Charles N; Mekalanos John J
The opportunistic pathogen Pseudomonas aeruginosa carries a secretable arachidonate 15-lipoxygenase.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(7):2135-9.
2004: Faruque Shah M; Chowdhury Nityananda; Kamruzzaman M; Dziejman Michelle; Rahman M Hasibur; Sack David A; Nair G Balakrish; Mekalanos John J
Genetic diversity and virulence potential of environmental Vibrio cholerae population in a cholera-endemic area.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(7):2123-8.
2003: Faruque Shah M; Mekalanos John J
Pathogenicity islands and phages in Vibrio cholerae evolution.
Trends in microbiology 2003;11(11):505-10.
2003: Zhu Jun; Mekalanos John J
Quorum sensing-dependent biofilms enhance colonization in Vibrio cholerae.
Developmental cell 2003;5(4):647-56.
2003: Rhie Gi-Eun; Roehrl Michael H; Mourez Michael; Collier R John; Mekalanos John J; Wang Julia Y
A dually active anthrax vaccine that confers protection against both bacilli and toxins.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(19):10925-30.
2003: Faruque Shah M; Zhu Jun; Asadulghani; Kamruzzaman M; Mekalanos John J
Examination of diverse toxin-coregulated pilus-positive Vibrio cholerae strains fails to demonstrate evidence for Vibrio pathogenicity island phage.
Infection and immunity 2003;71(6):2993-9.
2003: Vance Russell E; Zhu Jun; Mekalanos John J
A constitutively active variant of the quorum-sensing regulator LuxO affects protease production and biofilm formation in Vibrio cholerae.
Infection and immunity 2003;71(5):2571-6.
2003: Bina James; Zhu Jun; Dziejman Michelle; Faruque Shah; Calderwood Stephen; Mekalanos John
ToxR regulon of Vibrio cholerae and its expression in vibrios shed by cholera patients.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(5):2801-6.
2003: Xu Qing; Dziejman Michelle; Mekalanos John J
Determination of the transcriptome of Vibrio cholerae during intraintestinal growth and midexponential phase in vitro.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(3):1286-91.
2003: Faruque Shah M; Kamruzzaman M; Asadulghani; Sack David A; Mekalanos John J; Nair G Balakrish
CTXphi-independent production of the RS1 satellite phage by Vibrio cholerae.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(3):1280-5.
2002: Guo Betty P; Mekalanos John J
Rapid genetic analysis of Helicobacter pylori gastric mucosal colonization in suckling mice.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(12):8354-9.
2002: Fullner Karla Jean; Boucher John C; Hanes Martha A; Haines G Kenneth; Meehan Brian M; Walchle Cynthia; Sansonetti Philippe J; Mekalanos John J
The contribution of accessory toxins of Vibrio cholerae O1 El Tor to the proinflammatory response in a murine pulmonary cholera model.
The Journal of experimental medicine 2002;195(11):1455-62.
2002: Buddelmeijer Nienke; Judson Nicholas; Boyd Dana; Mekalanos John J; Beckwith Jonathan
YgbQ, a cell division protein in Escherichia coli and Vibrio cholerae, localizes in codependent fashion with FtsL to the division site.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(9):6316-21.
2002: Pukatzki Stefan; Kessin Richard H; Mekalanos John J
The human pathogen Pseudomonas aeruginosa utilizes conserved virulence pathways to infect the social amoeba Dictyostelium discoideum.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(5):3159-64.
2002: Zhu Jun; Miller Melissa B; Vance Russell E; Dziejman Michelle; Bassler Bonnie L; Mekalanos John J
Quorum-sensing regulators control virulence gene expression in Vibrio cholerae.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(5):3129-34.
2002: Dziejman Michelle; Balon Emmy; Boyd Dana; Fraser Clare M; Heidelberg John F; Mekalanos John J
Comparative genomic analysis of Vibrio cholerae: genes that correlate with cholera endemic and pandemic disease.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(3):1556-61.
2002: Akerley Brian J; Rubin Eric J; Novick Veronica L; Amaya Kensey; Judson Nicholas; Mekalanos John J
A genome-scale analysis for identification of genes required for growth or survival of Haemophilus influenzae.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(2):966-71.
2002: Faruque Shah M; Asadulghani; Kamruzzaman M; Nandi Ranjan K; Ghosh A N; Nair G Balakrish; Mekalanos John J; Sack David A
RS1 element of Vibrio cholerae can propagate horizontally as a filamentous phage exploiting the morphogenesis genes of CTXphi.
Infection and immunity 2002;70(1):163-70.
2001: Fullner K J; Lencer W I; Mekalanos J J
Vibrio cholerae-induced cellular responses of polarized T84 intestinal epithelial cells are dependent on production of cholera toxin and the RTX toxin.
Infection and immunity 2001;69(10):6310-7.
2001: Faruque S M; Rahman M M; Hasan A K; Nair G B; Mekalanos J J; Sack D A
Diminished diarrheal response to Vibrio cholerae strains carrying the replicative form of the CTX(Phi) genome instead of CTX(Phi) lysogens in adult rabbits.
Infection and immunity 2001;69(10):6084-90.
2001: Bina J E; Mekalanos J J
Vibrio cholerae tolC is required for bile resistance and colonization.
Infection and immunity 2001;69(7):4681-5.
2001: Guo B P; Mekalanos J J
Helicobacter pylori mutagenesis by mariner in vitro transposition.
FEMS immunology and medical microbiology 2001;30(2):87-93.
2000: Judson N; Mekalanos J J
Transposon-based approaches to identify essential bacterial genes.
Trends in microbiology 2000;8(11):521-6.
2000: Mel S F; Fullner K J; Wimer-Mackin S; Lencer W I; Mekalanos J J
Association of protease activity in Vibrio cholerae vaccine strains with decreases in transcellular epithelial resistance of polarized T84 intestinal epithelial cells.
Infection and immunity 2000;68(11):6487-92.
2000: Chiang S L; Mekalanos J J
Construction of a Vibrio cholerae vaccine candidate using transposon delivery and FLP recombinase-mediated excision.
Infection and immunity 2000;68(11):6391-7.
2000: Fullner K J; Mekalanos J J
In vivo covalent cross-linking of cellular actin by the Vibrio cholerae RTX toxin.
The EMBO journal 2000;19(20):5315-23.
2000: Wong S M; Mekalanos J J
Genetic footprinting with mariner-based transposition in Pseudomonas aeruginosa.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(18):10191-6.
2000: Judson N; Mekalanos J J
TnAraOut, a transposon-based approach to identify and characterize essential bacterial genes.
Nature biotechnology 2000;18(7):740-5.
2000: Blum J H; Dove S L; Hochschild A; Mekalanos J J
Isolation of peptide aptamers that inhibit intracellular processes.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(5):2241-6.
2000: Jain V; Mekalanos J J
Use of lambda phage S and R gene products in an inducible lysis system for Vibrio cholerae- and Salmonella enterica serovar typhimurium-based DNA vaccine delivery systems.
Infection and immunity 2000;68(2):986-9.
1999: Faruque S M; Rahman M M; Asadulghani; Nasirul Islam K M; Mekalanos J J
Lysogenic conversion of environmental Vibrio mimicus strains by CTXPhi.
Infection and immunity 1999;67(11):5723-9.
1999: Lampe D J; Akerley B J; Rubin E J; Mekalanos J J; Robertson H M
Hyperactive transposase mutants of the Himar1 mariner transposon.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(20):11428-33.
1999: Häse C C; Mekalanos J J
Effects of changes in membrane sodium flux on virulence gene expression in Vibrio cholerae.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(6):3183-7.
1999: Fullner K J; Mekalanos J J
Genetic characterization of a new type IV-A pilus gene cluster found in both classical and El Tor biotypes of Vibrio cholerae.
Infection and immunity 1999;67(3):1393-404.
1999: Rubin E J; Akerley B J; Novik V N; Lampe D J; Husson R N; Mekalanos J J
In vivo transposition of mariner-based elements in enteric bacteria and mycobacteria.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(4):1645-50.
1999: Lin W; Fullner K J; Clayton R; Sexton J A; Rogers M B; Calia K E; Calderwood S B; Fraser C; Mekalanos J J
Identification of a vibrio cholerae RTX toxin gene cluster that is tightly linked to the cholera toxin prophage.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(3):1071-6.
1999: Chiang S L; Mekalanos J J
rfb mutations in Vibrio cholerae do not affect surface production of toxin-coregulated pili but still inhibit intestinal colonization.
Infection and immunity 1999;67(2):976-80.
1999: Dziejman M; Kolmar H; Fritz H J; Mekalanos J J
ToxR co-operative interactions are not modulated by environmental conditions or periplasmic domain conformation.
Molecular microbiology 1999;31(1):305-17.
1999: Chiang S L; Mekalanos J J; Holden D W
In vivo genetic analysis of bacterial virulence.
Annual review of microbiology 1999;53():129-54.
1998: Faruque S M; Albert M J; Mekalanos J J
Epidemiology, genetics, and ecology of toxigenic Vibrio cholerae.
Microbiology and molecular biology reviews : MMBR 1998;62(4):1301-14.
1998: Faruque S M; Asadulghani; Saha M N; Alim A R; Albert M J; Islam K M; Mekalanos J J
Analysis of clinical and environmental strains of nontoxigenic Vibrio cholerae for susceptibility to CTXPhi: molecular basis for origination of new strains with epidemic potential.
Infection and immunity 1998;66(12):5819-25.
1998: Faruque S M; Asadulghani; Alim A R; Albert M J; Islam K M; Mekalanos J J
Induction of the lysogenic phage encoding cholera toxin in naturally occurring strains of toxigenic Vibrio cholerae O1 and O139.
Infection and immunity 1998;66(8):3752-7.
1998: Akerley B J; Rubin E J; Camilli A; Lampe D J; Robertson H M; Mekalanos J J
Systematic identification of essential genes by in vitro mariner mutagenesis.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(15):8927-32.
1998: Rubin E J; Lin W; Mekalanos J J; Waldor M K
Replication and integration of a Vibrio cholerae cryptic plasmid linked to the CTX prophage.
Molecular microbiology 1998;28(6):1247-54.
1998: Martinez de Tejada G; Cotter P A; Heininger U; Camilli A; Akerley B J; Mekalanos J J; Miller J F
Neither the Bvg- phase nor the vrg6 locus of Bordetella pertussis is required for respiratory infection in mice.
Infection and immunity 1998;66(6):2762-8.
1998: Klose K E; Mekalanos J J
Distinct roles of an alternative sigma factor during both free-swimming and colonizing phases of the Vibrio cholerae pathogenic cycle.
Molecular microbiology 1998;28(3):501-20.
1998: Chiang S L; Mekalanos J J
Use of signature-tagged transposon mutagenesis to identify Vibrio cholerae genes critical for colonization.
Molecular microbiology 1998;27(4):797-805.
1998: Klose K E; Mekalanos J J
Differential regulation of multiple flagellins in Vibrio cholerae.
Journal of bacteriology 1998;180(2):303-16.
1998: Häse C C; Mekalanos J J
TcpP protein is a positive regulator of virulence gene expression in Vibrio cholerae.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(2):730-4.
1997: Mekalanos J J; Rubin E J; Waldor M K
Cholera: molecular basis for emergence and pathogenesis.
FEMS immunology and medical microbiology 1997;18(4):241-8.
1997: Klose K E; Mekalanos J J
Simultaneous prevention of glutamine synthesis and high-affinity transport attenuates Salmonella typhimurium virulence.
Infection and immunity 1997;65(2):587-96.
1996: Mel S F; Mekalanos J J
Modulation of horizontal gene transfer in pathogenic bacteria by in vivo signals.
Cell 1996;87(5):795-8.
1996: Slauch J M; Lee A A; Mahan M J; Mekalanos J J
Molecular characterization of the oafA locus responsible for acetylation of Salmonella typhimurium O-antigen: oafA is a member of a family of integral membrane trans-acylases.
Journal of bacteriology 1996;178(20):5904-9.
1996: Waldor M K; Tschäpe H; Mekalanos J J
A new type of conjugative transposon encodes resistance to sulfamethoxazole, trimethoprim, and streptomycin in Vibrio cholerae O139.
Journal of bacteriology 1996;178(14):4157-65.
1996: Gardel C L; Mekalanos J J
Alterations in Vibrio cholerae motility phenotypes correlate with changes in virulence factor expression.
Infection and immunity 1996;64(6):2246-55.
1996: Waldor M K; Mekalanos J J
Lysogenic conversion by a filamentous phage encoding cholera toxin.
Science (New York, N.Y.) 1996;272(5270):1910-4.
1996: Reidl J; Mekalanos J J
Lipoprotein e(P4) is essential for hemin uptake by Haemophilus influenzae.
The Journal of experimental medicine 1996;183(2):621-9.
1996: Ottemann K M; Mekalanos J J
The ToxR protein of Vibrio cholerae forms homodimers and heterodimers.
Journal of bacteriology 1996;178(1):156-62.
1995: Reidl J; Mekalanos J J
Characterization of Vibrio cholerae bacteriophage K139 and use of a novel mini-transposon to identify a phage-encoded virulence factor.
Molecular microbiology 1995;18(4):685-701.
1995: Camilli A; Mekalanos J J
Use of recombinase gene fusions to identify Vibrio cholerae genes induced during infection.
Molecular microbiology 1995;18(4):671-83.
1995: Chiang S L; Taylor R K; Koomey M; Mekalanos J J
Single amino acid substitutions in the N-terminus of Vibrio cholerae TcpA affect colonization, autoagglutination, and serum resistance.
Molecular microbiology 1995;17(6):1133-42.
1995: Ottemann K M; Mekalanos J J
Analysis of Vibrio cholerae ToxR function by construction of novel fusion proteins.
Molecular microbiology 1995;15(4):719-31.
1995: Slauch J M; Mahan M J; Michetti P; Neutra M R; Mekalanos J J
Acetylation (O-factor 5) affects the structural and immunological properties of Salmonella typhimurium lipopolysaccharide O antigen.
Infection and immunity 1995;63(2):437-41.
1995: Mahan M J; Tobias J W; Slauch J M; Hanna P C; Collier R J; Mekalanos J J
Antibiotic-based selection for bacterial genes that are specifically induced during infection of a host.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(3):669-73.
1994: Waldor M K; Colwell R; Mekalanos J J
The Vibrio cholerae O139 serogroup antigen includes an O-antigen capsule and lipopolysaccharide virulence determinants.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(24):11388-92.
1994: Michetti P; Porta N; Mahan M J; Slauch J M; Mekalanos J J; Blum A L; Kraehenbuhl J P; Neutra M R
Monoclonal immunoglobulin A prevents adherence and invasion of polarized epithelial cell monolayers by Salmonella typhimurium.
Gastroenterology 1994;107(4):915-23.
1994: Mekalanos J J; Sadoff J C
Cholera vaccines: fighting an ancient scourge.
Science (New York, N.Y.) 1994;265(5177):1387-9.
1994: Waldor M K; Mekalanos J J
Emergence of a new cholera pandemic: molecular analysis of virulence determinants in Vibrio cholerae O139 and development of a live vaccine prototype.
The Journal of infectious diseases 1994;170(2):278-83.
1994: Dziejman M; Mekalanos J J
Analysis of membrane protein interaction: ToxR can dimerize the amino terminus of phage lambda repressor.
Molecular microbiology 1994;13(3):485-94.
1994: Mekalanos J J
Live bacterial vaccines: environmental aspects.
Current opinion in biotechnology 1994;5(3):312-9.
1994: Slauch J M; Mahan M J; Mekalanos J J
Measurement of transcriptional activity in pathogenic bacteria recovered directly from infected host tissue.
BioTechniques 1994;16(4):641-4.
1994: Camilli A; Beattie D T; Mekalanos J J
Use of genetic recombination as a reporter of gene expression.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(7):2634-8.
1994: Waldor M K; Mekalanos J J
ToxR regulates virulence gene expression in non-O1 strains of Vibrio cholerae that cause epidemic cholera.
Infection and immunity 1994;62(1):72-8.
1994: Gardel C L; Mekalanos J J
Regulation of cholera toxin by temperature, pH, and osmolarity.
Methods in enzymology 1994;235():517-26.
1994: Slauch J M; Mahan M J; Mekalanos J J
In vivo expression technology for selection of bacterial genes specifically induced in host tissues.
Methods in enzymology 1994;235():481-92.
1993: Apter F M; Michetti P; Winner L S; Mack J A; Mekalanos J J; Neutra M R
Analysis of the roles of antilipopolysaccharide and anti-cholera toxin immunoglobulin A (IgA) antibodies in protection against Vibrio cholerae and cholera toxin by use of monoclonal IgA antibodies in vivo.
Infection and immunity 1993;61(12):5279-85.
1993: Apter F M; Lencer W I; Finkelstein R A; Mekalanos J J; Neutra M R
Monoclonal immunoglobulin A antibodies directed against cholera toxin prevent the toxin-induced chloride secretory response and block toxin binding to intestinal epithelial cells in vitro.
Infection and immunity 1993;61(12):5271-8.
1993: Mahan M J; Slauch J M; Mekalanos J J
Bacteriophage P22 transduction of integrated plasmids: single-step cloning of Salmonella typhimurium gene fusions.
Journal of bacteriology 1993;175(21):7086-91.
1993: Mahan M J; Slauch J M; Hanna P C; Camilli A; Tobias J W; Waldor M K; Mekalanos J J
Selection for bacterial genes that are specifically induced in host tissues: the hunt for virulence factors.
Infectious agents and disease 1993;2(4):263-8.
1993: Pearson G D; Woods A; Chiang S L; Mekalanos J J
CTX genetic element encodes a site-specific recombination system and an intestinal colonization factor.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(8):3750-4.
1993: Mahan M J; Slauch J M; Mekalanos J J
Selection of bacterial virulence genes that are specifically induced in host tissues.
Science (New York, N.Y.) 1993;259(5095):686-8.
1993: Beattie D T; Mahan M J; Mekalanos J J
Repressor binding to a regulatory site in the DNA coding sequence is sufficient to confer transcriptional regulation of the vir-repressed genes (vrg genes) in Bordetella pertussis.
Journal of bacteriology 1993;175(2):519-27.
1993: Mekalanos J J
Bacterial response to host signals: analysis and applications.
Harvey lectures 1993;89():1-13.
1992: Ottemann K M; DiRita V J; Mekalanos J J
ToxR proteins with substitutions in residues conserved with OmpR fail to activate transcription from the cholera toxin promoter.
Journal of bacteriology 1992;174(21):6807-14.
1992: Parsot C; Mekalanos J J
Structural analysis of the acfA and acfD genes of Vibrio cholerae: effects of DNA topology and transcriptional activators on expression.
Journal of bacteriology 1992;174(16):5211-8.
1992: Killeen K P; Escuyer V; Mekalanos J J; Collier R J
Reversion of recombinant toxoids: mutations in diphtheria toxin that partially compensate for active-site deletions.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(13):6207-9.
1992: Michetti P; Mahan M J; Slauch J M; Mekalanos J J; Neutra M R
Monoclonal secretory immunoglobulin A protects mice against oral challenge with the invasive pathogen Salmonella typhimurium.
Infection and immunity 1992;60(5):1786-92.
1992: Miller J F; Johnson S A; Black W J; Beattie D T; Mekalanos J J; Falkow S
Constitutive sensory transduction mutations in the Bordetella pertussis bvgS gene.
Journal of bacteriology 1992;174(3):970-9.
1992: Beattie D T; Shahin R; Mekalanos J J
A vir-repressed gene of Bordetella pertussis is required for virulence.
Infection and immunity 1992;60(2):571-7.
1992: Mekalanos J J
Environmental signals controlling expression of virulence determinants in bacteria.
Journal of bacteriology 1992;174(1):1-7.
1992: Mekalanos J J
Bacterial mucosal vaccines.
Advances in experimental medicine and biology 1992;327():43-50.
1991: Finn T M; Shahin R; Mekalanos J J
Characterization of vir-activated TnphoA gene fusions in Bordetella pertussis.
Infection and immunity 1991;59(9):3273-9.
1991: DiRita V J; Parsot C; Jander G; Mekalanos J J
Regulatory cascade controls virulence in Vibrio cholerae.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(12):5403-7.
1991: Parsot C; Mekalanos J J
Expression of the Vibrio cholerae gene encoding aldehyde dehydrogenase is under control of ToxR, the cholera toxin transcriptional activator.
Journal of bacteriology 1991;173(9):2842-51.
1991: Parsot C; Taxman E; Mekalanos J J
ToxR regulates the production of lipoproteins and the expression of serum resistance in Vibrio cholerae.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(5):1641-5.
1991: Winner L; Mack J; Weltzin R; Mekalanos J J; Kraehenbuhl J P; Neutra M R
New model for analysis of mucosal immunity: intestinal secretion of specific monoclonal immunoglobulin A from hybridoma tumors protects against Vibrio cholerae infection.
Infection and immunity 1991;59(3):977-82.
1991: DiRita V J; Mekalanos J J
Periplasmic interaction between two membrane regulatory proteins, ToxR and ToxS, results in signal transduction and transcriptional activation.
Cell 1991;64(1):29-37.
1991: Neutra M; Weltzin R; Winner L; Mack J; Michetti P; Morrison L; Fields B N; Mekalanos J J; Kraehenbuhl J P
Identification and use of protective monoclonal IgA antibodies against viral and bacterial pathogens.
Advances in experimental medicine and biology 1991;310():179-82.
1990: Beattie D T; Knapp S; Mekalanos J J
Evidence that modulation requires sequences downstream of the promoters of two vir-repressed genes of Bordetella pertussis.
Journal of bacteriology 1990;172(12):6997-7004.
1990: Parsot C; Mekalanos J J
Expression of ToxR, the transcriptional activator of the virulence factors in Vibrio cholerae, is modulated by the heat shock response.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(24):9898-902.
1990: Pearson G D; DiRita V J; Goldberg M B; Boyko S A; Calderwood S B; Mekalanos J J
New attenuated derivatives of Vibrio cholerae.
Research in microbiology 1990;141(7-8):893-9.
1990: Miller S I; Mekalanos J J
Constitutive expression of the phoP regulon attenuates Salmonella virulence and survival within macrophages.
Journal of bacteriology 1990;172(5):2485-90.
1989: Miller S I; Kukral A M; Mekalanos J J
A two-component regulatory system (phoP phoQ) controls Salmonella typhimurium virulence.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(13):5054-8.
1989: Taylor R K; Manoil C; Mekalanos J J
Broad-host-range vectors for delivery of TnphoA: use in genetic analysis of secreted virulence determinants of Vibrio cholerae.
Journal of bacteriology 1989;171(4):1870-8.
1989: Miller V L; DiRita V J; Mekalanos J J
Identification of toxS, a regulatory gene whose product enhances toxR-mediated activation of the cholera toxin promoter.
Journal of bacteriology 1989;171(3):1288-93.
1989: Miller S I; Mekalanos J J
Strategies for the development of vaccines for typhoid fever, shigellosis, and cholera.
Annals of the New York Academy of Sciences 1989;569():145-54.
1989: DiRita V J; Mekalanos J J
Genetic regulation of bacterial virulence.
Annual review of genetics 1989;23():455-82.
1988: Knapp S; Mekalanos J J
Two trans-acting regulatory genes (vir and mod) control antigenic modulation in Bordetella pertussis.
Journal of bacteriology 1988;170(11):5059-66.
1988: Peterson K M; Mekalanos J J
Characterization of the Vibrio cholerae ToxR regulon: identification of novel genes involved in intestinal colonization.
Infection and immunity 1988;56(11):2822-9.
1988: Miller V L; Mekalanos J J
A novel suicide vector and its use in construction of insertion mutations: osmoregulation of outer membrane proteins and virulence determinants in Vibrio cholerae requires toxR.
Journal of bacteriology 1988;170(6):2575-83.
1988: Hovde C J; Calderwood S B; Mekalanos J J; Collier R J
Evidence that glutamic acid 167 is an active-site residue of Shiga-like toxin I.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(8):2568-72.
1988: Calderwood S B; Mekalanos J J
Confirmation of the Fur operator site by insertion of a synthetic oligonucleotide into an operon fusion plasmid.
Journal of bacteriology 1988;170(2):1015-7.
1988: Betley M J; Mekalanos J J
Nucleotide sequence of the type A staphylococcal enterotoxin gene.
Journal of bacteriology 1988;170(1):34-41.
1988: Mekalanos J J; Peterson K M; Finn T; Knapp S
The pathogenesis and immunology of Vibrio cholerae and Bordetella pertussis.
Antonie van Leeuwenhoek 1988;54(5):379-87.
1987: Calderwood S B; Mekalanos J J
Iron regulation of Shiga-like toxin expression in Escherichia coli is mediated by the fur locus.
Journal of bacteriology 1987;169(10):4759-64.

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