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Fritz Melchers

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Szandor Simmons; Ingrid Wolf; Hans-Joachim Mollenkopf; Corinne Bouquet; Christopher Drewell; Marko Knoll; Fritz Melchers
Biphenotypic B-lymphoid/myeloid cells expressing low levels of Pax5: potential targets of BAL development.
Marko Knoll; Fritz Melchers; Szandor Simmons; Jürgen Wienands; Yuki Yanagisawa; Niklas Engels; Kazuo Ohnishi
The non-Ig parts of the VpreB and λ5 proteins of the surrogate light chain play opposite roles in the surface representation of the precursor B cell receptor.
Andreas Reimer; Katharina Seiler; Julia Tornack; Motokazu Tsuneto; Fritz Melchers
Reprogramming to iPS cells and their subsequent hematopoietic differentiation is more efficient from MEFs than from preB cells.

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2012: Szandor Simmons; Ingrid Wolf; Hans-Joachim Mollenkopf; Corinne Bouquet; Christopher Drewell; Marko Knoll; Fritz Melchers
Biphenotypic B-lymphoid/myeloid cells expressing low levels of Pax5: potential targets of BAL development.
Blood 2012;120(18):3688-98.
2012: Marko Knoll; Fritz Melchers; Szandor Simmons; Jürgen Wienands; Yuki Yanagisawa; Niklas Engels; Kazuo Ohnishi
The non-Ig parts of the VpreB and λ5 proteins of the surrogate light chain play opposite roles in the surface representation of the precursor B cell receptor.
Journal of immunology (Baltimore, Md. : 1950) 2012;188(12):6010-7.
2012: Andreas Reimer; Katharina Seiler; Julia Tornack; Motokazu Tsuneto; Fritz Melchers
Reprogramming to iPS cells and their subsequent hematopoietic differentiation is more efficient from MEFs than from preB cells.
Immunology letters 2012;143(1):70-6.
2012: Fritz Melchers
The Basel Institute for Immunology.
Annual review of immunology 2012;30():23-38.
2007: Reinhard Hoffmann; Claudio Lottaz; Thomas Kühne; Antonius G Rolink; Fritz Melchers
Neutrality, compensation, and negative selection during evolution of B-cell development transcriptomes.
Molecular biology and evolution 2007;24(12):2610-8.
2007: Fritz Melchers; Tamotsu Yamagami; Antonius G Rolink; Jan Andersson
Rules for the rearrangement events at the L chain gene loci of the mouse.
Advances in experimental medicine and biology 2007;596():63-70.
2006: Fritz Melchers; A R Rolink
B cell tolerance--how to make it and how to break it.
Current topics in microbiology and immunology 2006;305():1-23.
2006: Cornelia Mundt; Steve Licence; Gavin Maxwell; Fritz Melchers; Inga-Lill Mårtensson
Only VpreB1, but not VpreB2, is expressed at levels which allow normal development of B cells.
International immunology 2006;18(1):163-72.
2005: Fritz Melchers
B cell development and its deregulation to transformed states at the pre-B cell receptor-expressing pre-BII cell stage.
Current topics in microbiology and immunology 2005;294():1-17.
2004: Antonius G Rolink; Jan Andersson; Fritz Melchers
Molecular mechanisms guiding late stages of B-cell development.
Immunological reviews 2004;197():41-50.
2003: Fritz Melchers
Actions of BAFF in B cell maturation and its effects on the development of autoimmune disease.
Annals of the rheumatic diseases 2003;62 Suppl 2():ii25-7.
2003: Reinhard Hoffmann; Ludovica Bruno; Thomas Seidl; Antonius G Rolink; Fritz Melchers
Rules for gene usage inferred from a comparison of large-scale gene expression profiles of T and B lymphocyte development.
Journal of immunology (Baltimore, Md. : 1950) 2003;170(3):1339-53.
2003: Klaus Felix; Antonius G Rolink; Fritz Melchers; Siegfried Janz
Bcl-2 reduces mutant rates in a transgenic lacZ reporter gene in mouse pre-B lymphocytes.
Mutation research 2003;522(1-2):135-44.
2002: Inga-Lill Mårtensson; Antonius G Rolink; Fritz Melchers; Cornelia Mundt; Steve Licence; Takeyuki Shimizu
The pre-B cell receptor and its role in proliferation and Ig heavy chain allelic exclusion.
Seminars in immunology 2002;14(5):335-42.
2002: Antonius G Rolink; Christoph Schaniel; Fritz Melchers
Stability and plasticity of wild-type and Pax5-deficient precursor B cells.
Immunological reviews 2002;187():87-95.
2002: Antonius G Rolink; Jürg Tschopp; Pascal Schneider; Fritz Melchers
BAFF is a survival and maturation factor for mouse B cells.
European journal of immunology 2002;32(7):2004-10.
2002: Takeyuki Shimizu; Cornelia Mundt; Steve Licence; Fritz Melchers; Inga-Lill Mårtensson
VpreB1/VpreB2/lambda 5 triple-deficient mice show impaired B cell development but functional allelic exclusion of the IgH locus.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(12):6286-93.
2002: Antonius G Rolink; Christoph Schaniel; Ludovica Bruno; Fritz Melchers
In vitro and in vivo plasticity of Pax5-deficient pre-B I cells.
Immunology letters 2002;82(1-2):35-40.
2002: Christoph Schaniel; Marie Gottar; Eddy Roosnek; Fritz Melchers; Antonius G Rolink
Extensive in vivo self-renewal, long-term reconstitution capacity, and hematopoietic multipotency of Pax5-deficient precursor B-cell clones.
Blood 2002;99(8):2760-6.
2002: Antonius G Rolink; Fritz Melchers
BAFFled B cells survive and thrive: roles of BAFF in B-cell development.
Current opinion in immunology 2002;14(2):266-75.
2002: Christoph Schaniel; Ludovica Bruno; Fritz Melchers; Antonius G Rolink
Multiple hematopoietic cell lineages develop in vivo from transplanted Pax5-deficient pre-B I-cell clones.
Blood 2002;99(2):472-8.
2002: Reinhard Hoffmann; Thomas Seidl; Martin Neeb; Antonius G Rolink; Fritz Melchers
Changes in gene expression profiles in developing B cells of murine bone marrow.
Genome research 2002;12(1):98-111.
2001: Thomas Seidl; Antonius G Rolink; Fritz Melchers
The VpreB protein of the surrogate light-chain can pair with some mu heavy-chains in the absence of the lambda 5 protein.
European journal of immunology 2001;31(7):1999-2006.
2001: Antonius G Rolink; Christoph Schaniel; J Andersson; Fritz Melchers
Selection events operating at various stages in B cell development.
Current opinion in immunology 2001;13(2):202-7.
2001: Cornelia Mundt; Steve Licence; Takeyuki Shimizu; Fritz Melchers; Inga-Lill Mårtensson
Loss of precursor B cell expansion but not allelic exclusion in VpreB1/VpreB2 double-deficient mice.
The Journal of experimental medicine 2001;193(4):435-45.
2001: Jürgen Hess; A Werner; Thomas Wirth; Fritz Melchers; Hans-Martin Jäck; T H Winkler
Induction of pre-B cell proliferation after de novo synthesis of the pre-B cell receptor.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(4):1745-50.
2001: Christoph Schaniel; Antonius G Rolink; Fritz Melchers
Attractions and migrations of lymphoid cells in the organization of humoral immune responses.
Advances in immunology 2001;78():111-68.
2000: K Ohnishi; T Shimizu; H Karasuyama; Fritz Melchers
The identification of a nonclassical cadherin expressed during B cell development and its interaction with surrogate light chain.
The Journal of biological chemistry 2000;275(40):31134-44.
2000: Antonius G Rolink; Christoph Schaniel; M Busslinger; SL Nutt; Fritz Melchers
Fidelity and infidelity in commitment to B-lymphocyte lineage development.
Immunological reviews 2000;175():104-11.
2000: Fritz Melchers; E ten Boekel; Thomas Seidl; X C Kong; T Yamagami; K Onishi; T Shimizu; Antonius G Rolink; J Andersson
Repertoire selection by pre-B-cell receptors and B-cell receptors, and genetic control of B-cell development from immature to mature B cells.
Immunological reviews 2000;175():33-46.
2000: Paolo Ghia; Fritz Melchers; A G Rolink
Age-dependent changes in B lymphocyte development in man and mouse.
Experimental gerontology 2000;35(2):159-65.
2000: Rhodri Ceredig; Antonius G Rolink; Fritz Melchers; J Andersson
The B cell receptor, but not the pre-B cell receptor, mediates arrest of B cell differentiation.
European journal of immunology 2000;30(3):759-67.
2000: M Ogawa; E ten Boekel; Fritz Melchers
Identification of CD19(-)B220(+)c-Kit(+)Flt3/Flk-2(+)cells as early B lymphoid precursors before pre-B-I cells in juvenile mouse bone marrow.
International immunology 2000;12(3):313-24.
2000: Antonius G Rolink; T Winkler; Fritz Melchers; J Andersson
Precursor B cell receptor-dependent B cell proliferation and differentiation does not require the bone marrow or fetal liver environment.
The Journal of experimental medicine 2000;191(1):23-32.
2000: Christoph Schaniel; Fritz Melchers; Antonius G Rolink
The cluster of ABCD chemokines which organizes T cell-dependent B cell responses.
Current topics in microbiology and immunology 2000;251():181-9.
2000: Antonius G Rolink; Fritz Melchers
Precursor B cells from Pax-5-deficient mice--stem cells for macrophages, granulocytes, osteoclasts, dendritic cells, natural killer cells, thymocytes and T cells.
Current topics in microbiology and immunology 2000;251():21-6.
1999: Fritz Melchers; Antonius G Rolink; Christoph Schaniel
The role of chemokines in regulating cell migration during humoral immune responses.
Cell 1999;99(4):351-4.
1999: Antonius G Rolink; SL Nutt; Fritz Melchers; M Busslinger
Long-term in vivo reconstitution of T-cell development by Pax5-deficient B-cell progenitors.
Nature 1999;401(6753):603-6.
1999: Fritz Melchers; E ten Boekel; T Yamagami; J Andersson; Antonius G Rolink
The roles of preB and B cell receptors in the stepwise allelic exclusion of mouse IgH and L chain gene loci.
Seminars in immunology 1999;11(5):307-17.
1999: T Yamagami; E ten Boekel; J Andersson; Antonius G Rolink; Fritz Melchers
Frequencies of multiple IgL chain gene rearrangements in single normal or kappaL chain-deficient B lineage cells.
Immunity 1999;11(3):317-27.
1999: T Yamagami; E ten Boekel; Christoph Schaniel; J Andersson; Antonius G Rolink; Fritz Melchers
Four of five RAG-expressing JCkappa-/- small pre-BII cells have no L chain gene rearrangements: detection by high-efficiency single cell PCR.
Immunity 1999;11(3):309-16.
1999: Christoph Schaniel; Federica Sallusto; C Ruedl; Paschalis Sideras; Fritz Melchers; Antonius G Rolink
Three chemokines with potential functions in T lymphocyte-independent and -dependent B lymphocyte stimulation.
European journal of immunology 1999;29(9):2934-47.
1999: Rhodri Ceredig; J Andersson; Fritz Melchers; A Rolink
Effect of deregulated IL-7 transgene expression on B lymphocyte development in mice expressing mutated pre-B cell receptors.
European journal of immunology 1999;29(9):2797-807.
1999: Wenjie Yu; H Nagaoka; Mila Jankovic; Ziva Misulovin; H Suh; A Rolink; Fritz Melchers; Eric Meffre; Michel C Nussenzweig
Continued RAG expression in late stages of B cell development and no apparent re-induction after immunization.
Nature 1999;400(6745):682-7.
1999: Antonius G Rolink; E ten Boekel; T Yamagami; Rhodri Ceredig; J Andersson; Fritz Melchers
B cell development in the mouse from early progenitors to mature B cells.
Immunology letters 1999;68(1):89-93.
1999: Antonius G Rolink; T Brocker; H Bluethmann; M H Kosco-Vilbois; J Andersson; Fritz Melchers
Mutations affecting either generation or survival of cells influence the pool size of mature B cells.
Immunity 1999;10(5):619-28.
1999: Fritz Melchers
Fit for life in the immune system? Surrogate L chain tests H chains that test L chains.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(6):2571-3.
1999: A Mårtensson; Yair Argon; Fritz Melchers; JL Dul; Inga-Lill Mårtensson
Partial block in B lymphocyte development at the transition into the pre-B cell receptor stage in Vpre-B1-deficient mice.
International immunology 1999;11(3):453-60.
1999: Antonius G Rolink; SL Nutt; Meinrad Busslinger; E ten Boekel; Thomas Seidl; J Andersson; Fritz Melchers
Differentiation, dedifferentiation, and redifferentiation of B-lineage lymphocytes: roles of the surrogate light chain and the Pax5 gene.
Cold Spring Harbor symposia on quantitative biology 1999;64():21-5.
1999: Christoph Schaniel; Federica Sallusto; Paschalis Sideras; Fritz Melchers; Antonius G Rolink
A novel CC chemokine ABCD-1, produced by dendritic cells and activated B cells, exclusively attracts activated T lymphocytes.
Current topics in microbiology and immunology 1999;246():95-101.
1999: Antonius G Rolink; Fritz Melchers; J Andersson
The transition from immature to mature B cells.
Current topics in microbiology and immunology 1999;246():39-43; discussion 44.
1999: Rhodri Ceredig; Antonius G Rolink; Fritz Melchers; J Andersson
Fetal liver organ cultures as a tool to study selection processes during B cell development.
Current topics in microbiology and immunology 1999;246():11-7; discussion 18-9.
1999: E ten Boekel; T Yamagami; J Andersson; Antonius G Rolink; Fritz Melchers
The formation and selection of cells expressing preB cell receptors and B cell receptors.
Current topics in microbiology and immunology 1999;246():3-9; discussion 9-10.
1998: Antonius G Rolink; J Andersson; Fritz Melchers
Characterization of immature B cells by a novel monoclonal antibody, by turnover and by mitogen reactivity.
European journal of immunology 1998;28(11):3738-48.
1998: Paolo Ghia; E ten Boekel; Antonius G Rolink; Fritz Melchers
B-cell development: a comparison between mouse and man.
Immunology today 1998;19(10):480-5.
1998: Christoph Schaniel; Evangelia Pardali; Federica Sallusto; Matthaios Speletas; C Ruedl; T Shimizu; Thomas Seidl; J Andersson; Fritz Melchers; Antonius G Rolink; Paschalis Sideras
Activated murine B lymphocytes and dendritic cells produce a novel CC chemokine which acts selectively on activated T cells.
The Journal of experimental medicine 1998;188(3):451-63.
1998: D G Osmond; A Rolink; Fritz Melchers
Murine B lymphopoiesis: towards a unified model.
Immunology today 1998;19(2):65-8.
1998: E ten Boekel; Fritz Melchers; Antonius G Rolink
Precursor B cells showing H chain allelic inclusion display allelic exclusion at the level of pre-B cell receptor surface expression.
Immunity 1998;8(2):199-207.
1998: Rhodri Ceredig; E ten Boekel; Antonius G Rolink; Fritz Melchers; J Andersson
Fetal liver organ cultures allow the proliferative expansion of pre-B receptor-expressing pre-B-II cells and the differentiation of immature and mature B cells in vitro.
International immunology 1998;10(1):49-59.
1997: C P Kalberer; L Reininger; Fritz Melchers; Antonius G Rolink
Priming of helper T cell-dependent antibody responses by hemagglutinin-transgenic B cells.
European journal of immunology 1997;27(9):2400-7.
1997: E ten Boekel; Fritz Melchers; Antonius G Rolink
Changes in the V(H) gene repertoire of developing precursor B lymphocytes in mouse bone marrow mediated by the pre-B cell receptor.
Immunity 1997;7(3):357-68.
1997: M D'Apuzzo; A Rolink; M Loetscher; J A Hoxie; Ian Clark-Lewis; Fritz Melchers; Marco Baggiolini; Bernhard Moser
The chemokine SDF-1, stromal cell-derived factor 1, attracts early stage B cell precursors via the chemokine receptor CXCR4.
European journal of immunology 1997;27(7):1788-93.
1997: Fritz Melchers
The Carl Prausnitz Memorial Lecture. The development of lymphocytes.
International archives of allergy and immunology 1997;113(1-3):11-3.
1997: Inga-Lill Mårtensson; Fritz Melchers; Thomas H Winkler
A transgenic marker for mouse B lymphoid precursors.
The Journal of experimental medicine 1997;185(4):653-61.
1997: D Siwarski; U Müller; J Andersson; Vicente Notario; Fritz Melchers; A Rolink; Konrad Huppi
Structure and expression of the c-Myc/Pvt 1 megagene locus.
Current topics in microbiology and immunology 1997;224():67-72.
1997: Fritz Melchers
B-lymphocyte-lineage cells from early precursors to Ig-secreting plasma cells: targets of regulation by the myc/mad/max families of genes?
Current topics in microbiology and immunology 1997;224():19-30.
1997: Fritz Melchers
Control of the sizes and contents of precursor B cell repertoires in bone marrow.
Ciba Foundation symposium 1997;204():172-82; discussion 182-6.
1996: A Rolink; Fritz Melchers
B-cell development in the mouse.
Immunology letters 1996;54(2-3):157-61.
1996: Paolo Ghia; E ten Boekel; E Sanz; A de la Hera; Antonius G Rolink; Fritz Melchers
Ordering of human bone marrow B lymphocyte precursors by single-cell polymerase chain reaction analyses of the rearrangement status of the immunoglobulin H and L chain gene loci.
The Journal of experimental medicine 1996;184(6):2217-29.
1996: Y Oka; Antonius G Rolink; J Andersson; M Kamanaka; J Uchida; T Yasui; Tadamitsu Kishimoto; Hitoshi Kikutani; Fritz Melchers
Profound reduction of mature B cell numbers, reactivities and serum Ig levels in mice which simultaneously carry the XID and CD40 deficiency genes.
International immunology 1996;8(11):1675-85.
1996: Antonius G Rolink; Fritz Melchers; J Andersson
The SCID but not the RAG-2 gene product is required for S mu-S epsilon heavy chain class switching.
Immunity 1996;5(4):319-30.
1996: Luc Reininger; T H Winkler; C P Kalberer; M Jourdan; Fritz Melchers; Antonius G Rolink
Intrinsic B cell defects in NZB and NZW mice contribute to systemic lupus erythematosus in (NZB x NZW)F1 mice.
The Journal of experimental medicine 1996;184(3):853-61.
1996: U Grawunder; David G Schatz; T M Leu; Antonius G Rolink; Fritz Melchers
The half-life of RAG-1 protein in precursor B cells is increased in the absence of RAG-2 expression.
The Journal of experimental medicine 1996;183(4):1731-7.
1996: Antonius G Rolink; D Haasner; Fritz Melchers; J Andersson
The surrogate light chain in mouse B-cell development.
International reviews of immunology 1996;13(4):341-56.
1996: U Grawunder; T H Winkler; Fritz Melchers
Regulation of recombination activating gene expression during lymphocyte development.
Current topics in microbiology and immunology 1996;217():31-43.
1996: Antonius G Rolink; E ten Boekel; Fritz Melchers; D T Fearon; Ian Krop; J Andersson
A subpopulation of B220+ cells in murine bone marrow does not express CD19 and contains natural killer cell progenitors.
The Journal of experimental medicine 1996;183(1):187-94.
1995: U Grawunder; Antonius G Rolink; Fritz Melchers
Induction of sterile transcription from the kappa L chain gene locus in V(D)J recombinase-deficient progenitor B cells.
International immunology 1995;7(12):1915-25.
1995: U Grawunder; T M Leu; David G Schatz; A Werner; Antonius G Rolink; Fritz Melchers; T H Winkler
Down-regulation of RAG1 and RAG2 gene expression in preB cells after functional immunoglobulin heavy chain rearrangement.
Immunity 1995;3(5):601-8.
1995: Paolo Ghia; A Gratwohl; E Signer; T H Winkler; Fritz Melchers; Antonius G Rolink
Immature B cells from human and mouse bone marrow can change their surface light chain expression.
European journal of immunology 1995;25(11):3108-14.
1995: Fritz Melchers
B cell differentiation in bone marrow.
Clinical immunology and immunopathology 1995;76(3 Pt 2):S188-91.
1995: J Andersson; Fritz Melchers; Antonius G Rolink
Stimulation by T cell independent antigens can relieve the arrest of differentiation of immature auto-reactive B cells in the bone marrow.
Scandinavian journal of immunology 1995;42(1):21-33.
1995: Antonius G Rolink; Paolo Ghia; U Grawunder; D Haasner; H Karasuyama; C Kalberer; T Winkler; Fritz Melchers
In-vitro analyses of mechanisms of B-cell development.
Seminars in immunology 1995;7(3):155-67.
1995: E ten Boekel; Fritz Melchers; Antonius G Rolink
The status of Ig loci rearrangements in single cells from different stages of B cell development.
International immunology 1995;7(6):1013-9.
1995: Y Oka; Antonius G Rolink; S Suematsu; Tadamitsu Kishimoto; Fritz Melchers
An interleukin-6 transgene expressed in B lymphocyte lineage cells overcomes the T cell-dependent establishment of normal levels of switched immunoglobulin isotypes.
European journal of immunology 1995;25(5):1332-7.
1995: T H Winkler; Fritz Melchers; Antonius G Rolink
Interleukin-3 and interleukin-7 are alternative growth factors for the same B-cell precursors in the mouse.
Blood 1995;85(8):2045-51.
1995: Fritz Melchers; Antonius G Rolink; U Grawunder; T H Winkler; H Karasuyama; Paolo Ghia; J Andersson
Positive and negative selection events during B lymphopoiesis.
Current opinion in immunology 1995;7(2):214-27.
1995: T H Winkler; Antonius G Rolink; Fritz Melchers; H Karasuyama
Precursor B cells of mouse bone marrow express two different complexes with the surrogate light chain on the surface.
European journal of immunology 1995;25(2):446-50.
1994: Y Cahen-Kramer; I L Mårtensson; Fritz Melchers
The structure of an alternate form of complement C3 that displays costimulatory growth factor activity for B lymphocytes.
The Journal of experimental medicine 1994;180(6):2079-88.
1994: Antonius G Rolink; U Grawunder; T H Winkler; H Karasuyama; Fritz Melchers
IL-2 receptor alpha chain (CD25, TAC) expression defines a crucial stage in pre-B cell development.
International immunology 1994;6(8):1257-64.
1994: I L Mårtensson; Fritz Melchers
Pre-B cell-specific lambda 5 gene expression due to suppression in non pre-B cells.
International immunology 1994;6(6):863-72.
1994: Antonius G Rolink; Luc Reininger; Y Oka; C P Kalberer; T H Winkler; Fritz Melchers
Repopulation of SCID mice with long-term in vitro proliferating pre-B-cell lines from normal and autoimmune disease-prone mice.
Research in immunology 1994;145(5):353-6.
1994: F Young; B Ardman; Y Shinkai; R Lansford; T K Blackwell; Monica Mendelsohn; Antonius G Rolink; Fritz Melchers; F W Alt
Influence of immunoglobulin heavy- and light-chain expression on B-cell differentiation.
Genes & development 1994;8(9):1043-57.
1994: H Karasuyama; Antonius G Rolink; Y Shinkai; F Young; F W Alt; Fritz Melchers
The expression of Vpre-B/lambda 5 surrogate light chain in early bone marrow precursor B cells of normal and B cell-deficient mutant mice.
Cell 1994;77(1):133-43.
1994: Antonius G Rolink; H Karasuyama; D Haasner; U Grawunder; I L Mårtensson; A Kudo; Fritz Melchers
Two pathways of B-lymphocyte development in mouse bone marrow and the roles of surrogate L chain in this development.
Immunological reviews 1994;137():185-201.
1994: D Haasner; Antonius G Rolink; Fritz Melchers
Influence of surrogate L chain on DHJH-reading frame 2 suppression in mouse precursor B cells.
International immunology 1994;6(1):21-30.
1994: Fritz Melchers; D Haasner; U Grawunder; C Kalberer; H Karasuyama; T Winkler; Antonius G Rolink
Roles of IgH and L chains and of surrogate H and L chains in the development of cells of the B lymphocyte lineage.
Annual review of immunology 1994;12():209-25.
1993: U Grawunder; D Haasner; Fritz Melchers; Antonius G Rolink
Rearrangement and expression of kappa light chain genes can occur without mu heavy chain expression during differentiation of pre-B cells.
International immunology 1993;5(12):1609-18.
1993: Antonius G Rolink; U Grawunder; D Haasner; A Strasser; Fritz Melchers
Immature surface Ig+ B cells can continue to rearrange kappa and lambda L chain gene loci.
The Journal of experimental medicine 1993;178(4):1263-70.
1993: H Karasuyama; Antonius G Rolink; Fritz Melchers
A complex of glycoproteins is associated with VpreB/lambda 5 surrogate light chain on the surface of mu heavy chain-negative early precursor B cell lines.
The Journal of experimental medicine 1993;178(2):469-78.
1993: Antonius G Rolink; H Karasuyama; U Grawunder; D Haasner; A Kudo; Fritz Melchers
B cell development in mice with a defective lambda 5 gene.
European journal of immunology 1993;23(6):1284-8.
1993: Antonius G Rolink; D Haasner; S Nishikawa; Fritz Melchers
Changes in frequencies of clonable pre B cells during life in different lymphoid organs of mice.
Blood 1993;81(9):2290-300.
1993: Antonius G Rolink; Fritz Melchers
Generation and regeneration of cells of the B-lymphocyte lineage.
Current opinion in immunology 1993;5(2):207-17.
1993: U Grawunder; Fritz Melchers; Antonius G Rolink
Interferon-gamma arrests proliferation and causes apoptosis in stromal cell/interleukin-7-dependent normal murine pre-B cell lines and clones in vitro, but does not induce differentiation to surface immunoglobulin-positive B cells.
European journal of immunology 1993;23(2):544-51.
1993: Fritz Melchers; H Karasuyama; D Haasner; S Bauer; A Kudo; N Sakaguchi; B Jameson; Antonius G Rolink
The surrogate light chain in B-cell development.
Immunology today 1993;14(2):60-8.
1993: Antonius G Rolink; Fritz Melchers
B lymphopoiesis in the mouse.
Advances in immunology 1993;53():123-56.
1993: Fritz Melchers
The dominance of antigen-specific receptors in antigen-specific immune responses.
Current topics in microbiology and immunology 1993;184():1-3.
1992: Luc Reininger; T Radaszkiewicz; M Kosco; Fritz Melchers; Antonius G Rolink
Development of autoimmune disease in SCID mice populated with long-term "in vitro" proliferating (NZB x NZW)F1 pre-B cells.
The Journal of experimental medicine 1992;176(5):1343-53.
1992: A Kudo; P Thalmann; N Sakaguchi; W F Davidson; J H Pierce; J F Kearney; M Reth; Antonius G Rolink; Fritz Melchers
The expression of the mouse VpreB/lambda 5 locus in transformed cell lines and tumors of the B lineage differentiation pathway.
International immunology 1992;4(8):831-40.
1992: Fritz Melchers; D Haasner; H Karasuyama; L Reininger; Antonius G Rolink
Progenitor and precursor B lymphocytes of mice. Proliferation and differentiation in vitro and population, differentiation and turnover in SCID mice in vivo of normal and abnormal cells.
Current topics in microbiology and immunology 1992;182():3-12.
1992: Fritz Melchers; D Haasner; M Streb; Antonius G Rolink
B-lymphocyte lineage-committed, IL-7 and stroma cell-reactive progenitors and precursors, and their differentiation to B cells.
Advances in experimental medicine and biology 1992;323():111-7.
1991: Antonius G Rolink; M Streb; Fritz Melchers
The kappa/lambda ratio in surface immunoglobulin molecules on B lymphocytes differentiating from DHJH-rearranged murine pre-B cell clones in vitro.
European journal of immunology 1991;21(11):2895-8.
1991: Antonius G Rolink; M Streb; S Nishikawa; Fritz Melchers
The c-kit-encoded tyrosine kinase regulates the proliferation of early pre-B cells.
European journal of immunology 1991;21(10):2609-12.
1991: Antonius G Rolink; Fritz Melchers
Molecular and cellular origins of B lymphocyte diversity.
Cell 1991;66(6):1081-94.
1991: S R Bauer; H Kubagawa; I Maclennan; Fritz Melchers
VpreB gene expression in hematopoietic malignancies: a lineage- and stage-restricted marker for B-cell precursor leukemias.
Blood 1991;78(6):1581-8.
1991: Antonius G Rolink; A Kudo; H Karasuyama; Y Kikuchi; Fritz Melchers
Long-term proliferating early pre B cell lines and clones with the potential to develop to surface Ig-positive, mitogen reactive B cells in vitro and in vivo.
The EMBO journal 1991;10(2):327-36.
1991: Fritz Melchers; A Strasser; S R Bauer; A Kudo; P Thalmann; Antonius G Rolink
B cell development in fetal liver.
Advances in experimental medicine and biology 1991;292():201-5.
1989: A Strasser; Antonius G Rolink; Fritz Melchers
One synchronous wave of B cell development in mouse fetal liver changes at day 16 of gestation from dependence to independence of a stromal cell environment.
The Journal of experimental medicine 1989;170(6):1973-86.
1989: Antonius G Rolink; Fritz Melchers; R Palacios
Monoclonal antibodies reactive with the mouse interleukin 5 receptor.
The Journal of experimental medicine 1989;169(5):1693-701.
1989: Fritz Melchers; S R Bauer; C Berger; H Karasuyama; A Kudo; Antonius G Rolink; N Sakaguchi; A Strasser; P Thalmann
Precursor B lymphocytes--specific monoclonal antibodies and genes.
Advances in experimental medicine and biology 1989;254():87-93.
1989: Fritz Melchers; A Strasser; S R Bauer; A Kudo; P Thalmann; Antonius G Rolink
Cellular stages and molecular steps of murine B-cell development.
Cold Spring Harbor symposia on quantitative biology 1989;54 Pt 1():183-9.
1989: L A D'Hoostelaere; S R Bauer; Fritz Melchers
Restriction fragment analysis of V preB and lambda 5 within the genus Mus.
European journal of immunology 1989;19(1):37-42.
1988: Antonius G Rolink; P Thalmann; C Berger; T Radaszkiewicz; Fritz Melchers
Autoreactive B-cell repertoire in mice with chronic graft versus host disease.
Molecular immunology 1988;25(11):1217-22.
1988: H Karasuyama; Antonius G Rolink; Fritz Melchers
Recombinant interleukin 2 or 5, but not 3 or 4, induces maturation of resting mouse B lymphocytes and propagates proliferation of activated B cell blasts.
The Journal of experimental medicine 1988;167(4):1377-90.
1988: S R Bauer; A Kudo; Fritz Melchers
Structure and pre-B lymphocyte restricted expression of the VpreB in humans and conservation of its structure in other mammalian species.
The EMBO journal 1988;7(1):111-6.
1988: S R Bauer; K Huebner; M Budarf; J Finan; J Erikson; B S Emanuel; Peter C Nowell; C M Croce; Fritz Melchers
The human Vpre B gene is located on chromosome 22 near a cluster of V lambda gene segments.
Immunogenetics 1988;28(5):328-33.
1988: S R Bauer; L A D'Hoostelaere; Fritz Melchers
Conservation of the organization of the pre-B cell specific VpreB1/VpreB2/lambda 5 loci in the genus Mus.
Current topics in microbiology and immunology 1988;137():130-5.
1988: H Karasuyama; Fritz Melchers
Establishment of mouse cell lines which constitutively secrete large quantities of interleukin 2, 3, 4 or 5, using modified cDNA expression vectors.
European journal of immunology 1988;18(1):97-104.
1987: A Kudo; Fritz Melchers
A second gene, VpreB in the lambda 5 locus of the mouse, which appears to be selectively expressed in pre-B lymphocytes.
The EMBO journal 1987;6(8):2267-72.