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Daniela Melchiorri

Research Profile

Chemicals & Drugs

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Reverse Transcriptase Polymerase Chain Reaction

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C Ciceroni; Ruggero De Maria; L M Larocca; M Laurenza; E Mastrantoni; C Niccolini; Ferdinando Nicoletti; R Pallini; Lucia Ricci-Vitiani; Paola Spinsanti; A Traficante; Antonietta Arcella; Giuseppe Battaglia; M Bonelli; Daniela Melchiorri
Type-3 metabotropic glutamate receptors regulate chemoresistance in glioma stem cells, and their levels are inversely related to survival in patients with malignant gliomas.
Iran Sarichelou; Irene Cappuccio; F Ferranti; P Mosillo; C Ciceroni; sale Patrizio; Fabrizio Stocchi; Giuseppe Battaglia; Ferdinando Nicoletti; Daniela Melchiorri
Metabotropic glutamate receptors regulate differentiation of embryonic stem cells into GABAergic neurons.
Paola Spinsanti; Teresa De Vita; Alessandra Caruso; Daniela Melchiorri; Roberta Misasi; Andrea Caricasole; Ferdinando Nicoletti
Differential activation of the calcium/protein kinase C and the canonical beta-catenin pathway by Wnt1 and Wnt7a produces opposite effects on cell proliferation in PC12 cells.

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All Publications

2013: C Ciceroni; Ruggero De Maria; L M Larocca; M Laurenza; E Mastrantoni; C Niccolini; Ferdinando Nicoletti; R Pallini; Lucia Ricci-Vitiani; Paola Spinsanti; A Traficante; Antonietta Arcella; Giuseppe Battaglia; M Bonelli; Daniela Melchiorri
Type-3 metabotropic glutamate receptors regulate chemoresistance in glioma stem cells, and their levels are inversely related to survival in patients with malignant gliomas.
Cell death and differentiation 2013;20(3):396-407.
2008: Iran Sarichelou; Irene Cappuccio; F Ferranti; P Mosillo; C Ciceroni; sale Patrizio; Fabrizio Stocchi; Giuseppe Battaglia; Ferdinando Nicoletti; Daniela Melchiorri
Metabotropic glutamate receptors regulate differentiation of embryonic stem cells into GABAergic neurons.
Cell death and differentiation 2008;15(4):700-7.
2008: Paola Spinsanti; Teresa De Vita; Alessandra Caruso; Daniela Melchiorri; Roberta Misasi; Andrea Caricasole; Ferdinando Nicoletti
Differential activation of the calcium/protein kinase C and the canonical beta-catenin pathway by Wnt1 and Wnt7a produces opposite effects on cell proliferation in PC12 cells.
Journal of neurochemistry 2008;104(6):1588-98.
2008: Francesco Matrisciano; Morena Zusso; I Panaccione; B Turriziani; Alessandra Caruso; Luisa Iacovelli; L Noviello; Giuseppina I Togna; Daniela Melchiorri; Patrizia Debetto; Roberto Tatarelli; Giuseppe Battaglia; Ferdinando Nicoletti; Pietro Giusti; P Girardi
Synergism between fluoxetine and the mGlu2/3 receptor agonist, LY379268, in an in vitro model for antidepressant drug-induced neurogenesis.
Neuropharmacology 2008;54(2):428-37.
2007: Daniela Melchiorri; Irene Cappuccio; Cinzia Ciceroni; Paola Spinsanti; Paola Mosillo; Iran Sarichelou; sale Patrizio; Ferdinando Nicoletti
Metabotropic glutamate receptors in stem/progenitor cells.
Neuropharmacology 2007;53(4):473-80.
2007: Rosamaria Orlando; Alessandra Caruso; Gemma Molinaro; Marta Motolese; Francesco Matrisciano; Giuseppina Togna; Daniela Melchiorri; Ferdinando Nicoletti; Valeria Bruno
Nanomolar concentrations of anabolic-androgenic steroids amplify excitotoxic neuronal death in mixed mouse cortical cultures.
Brain research 2007;1165():21-9.
2007: Ferdinando Nicoletti; Giuseppe Battaglia; marianna storto; Richard Teke Ngomba; Luisa Iacovelli; Antonietta Arcella; Roberto Gradini; sale Patrizio; Liborio Rampello; Teresa De Vita; Roberto Di Marco; Daniela Melchiorri; Valeria Bruno
Metabotropic glutamate receptors: beyond the regulation of synaptic transmission.
Psychoneuroendocrinology 2007;32 Suppl 1():S40-5.
2007: Ferdinando Nicoletti; Antonietta Arcella; Luisa Iacovelli; Giuseppe Battaglia; Felice Giangaspero; Daniela Melchiorri
Metabotropic glutamate receptors: new targets for the control of tumor growth?
Trends in pharmacological sciences 2007;28(5):206-13.
2007: Maurizio Muscaritoli; Alessio Molfino; Maria Grazia Chiappini; Alessandro Laviano; Thomas Ammann; Paola Spinsanti; Daniela Melchiorri; Akio Inui; Filippo Alegiani; Filippo Rossi-Fanelli
Anorexia in hemodialysis patients: the possible role of des-acyl ghrelin.
American journal of nephrology 2007;27(4):360-5.
2007: R Verani; Irene Cappuccio; Paola Spinsanti; Roberto Gradini; Alessandra Caruso; M C Magnotti; Marta Motolese; Ferdinando Nicoletti; Daniela Melchiorri
Expression of the Wnt inhibitor Dickkopf-1 is required for the induction of neural markers in mouse embryonic stem cells differentiating in response to retinoic acid.
Journal of neurochemistry 2007;100(1):242-50.
2006: Paola Spinsanti; Teresa De Vita; Sara Di Castro; marianna storto; Pietro Formisano; Ferdinando Nicoletti; Daniela Melchiorri
Endogenously activated mGlu5 metabotropic glutamate receptors sustain the increase in c-Myc expression induced by leukaemia inhibitory factor in cultured mouse embryonic stem cells.
Journal of neurochemistry 2006;99(1):299-307.
2006: Irene Cappuccio; Roberta Verani; Paola Spinsanti; Cristiano Niccolini; Roberto Gradini; Santa Costantino; Ferdinando Nicoletti; Daniela Melchiorri
Context-dependent regulation of embryonic stem cell differentiation by mGlu4 metabotropic glutamate receptors.
Neuropharmacology 2006;51(3):606-11.
2006: Laura Calò; Carlo Cinque; Monica Patanè; Danilo Schillaci; Giuseppe Battaglia; Daniela Melchiorri; Ferdinando Nicoletti; Valeria Bruno
Interaction between ephrins/Eph receptors and excitatory amino acid receptors: possible relevance in the regulation of synaptic plasticity and in the pathophysiology of neuronal degeneration.
Journal of neurochemistry 2006;98(1):1-10.
2005: Concetta Marganella; Valeria Bruno; Francesco Matrisciano; Carlo Reale; Ferdinando Nicoletti; Daniela Melchiorri
Comparative effects of levobupivacaine and racemic bupivacaine on excitotoxic neuronal death in culture and N-methyl-D-aspartate-induced seizures in mice.
European journal of pharmacology 2005;518(2-3):111-5.
2005: Valeria Di Giorgi Gerevini; Daniela Melchiorri; Giuseppe Battaglia; Lucia Ricci-Vitiani; C Ciceroni; Carla L Busceti; Francesca Biagioni; Luisa Iacovelli; A M Teixido Canudas; Eugenio Parati; Ruggero De Maria; Ferdinando Nicoletti
Endogenous activation of metabotropic glutamate receptors supports the proliferation and survival of neural progenitor cells.
Cell death and differentiation 2005;12(8):1124-33.
2005: Francesco Matrisciano; Sergio Scaccianoce; Paola Del Bianco; I Panaccione; A M Teixido Canudas; Giuseppe Battaglia; Barbara Riozzi; Richard Teke Ngomba; Gemma Molinaro; Roberto Tatarelli; Daniela Melchiorri; Ferdinando Nicoletti
Metabotropic glutamate receptors and neuroadaptation to antidepressants: imipramine-induced down-regulation of beta-adrenergic receptors in mice treated with metabotropic glutamate 2/3 receptor ligands.
Journal of neurochemistry 2005;93(5):1345-52.
2005: Irene Cappuccio; Agata Calderone; Carla L Busceti; Francesca Biagioni; Fabrizio Pontarelli; Valeria Bruno; marianna storto; Georg T Terstappen; Giovanni Gaviraghi; Francesco Fornai; Giuseppe Battaglia; Daniela Melchiorri; R Suzanne Zukin; Suzanne Zukin; Ferdinando Nicoletti; Andrea Caricasole
Induction of Dickkopf-1, a negative modulator of the Wnt pathway, is required for the development of ischemic neuronal death.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2005;25(10):2647-57.
2005: L Calò; Valeria Bruno; Paola Spinsanti; G Molinari; Vladimir M Korkhov; Z Esposito; M Patanè; Daniela Melchiorri; Michael Freissmuth; Ferdinando Nicoletti
Interactions between ephrin-B and metabotropic glutamate 1 receptors in brain tissue and cultured neurons.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2005;25(9):2245-54.
2005: Irene Cappuccio; Paola Spinsanti; Antonio Porcellini; Francesca Desiderati; Teresa De Vita; marianna storto; Loredana Capobianco; Giuseppe Battaglia; Ferdinando Nicoletti; Daniela Melchiorri
Endogenous activation of mGlu5 metabotropic glutamate receptors supports self-renewal of cultured mouse embryonic stem cells.
Neuropharmacology 2005;49 Suppl 1():196-205.
2004: A M Teixido Canudas; Valeria Di Giorgi Gerevini; Luisa Iacovelli; G Nano; Mara D'Onofrio; Antonietta Arcella; Felice Giangaspero; Carla L Busceti; Lucia Ricci-Vitiani; Giuseppe Battaglia; Ferdinando Nicoletti; Daniela Melchiorri
PHCCC, a specific enhancer of type 4 metabotropic glutamate receptors, reduces proliferation and promotes differentiation of cerebellar granule cell neuroprecursors.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2004;24(46):10343-52.
2004: Valeria Di Giorgi Gerevini; Alessandra Caruso; Irene Cappuccio; Lucia Ricci-Vitiani; Salvatore Romeo; Carlo Della Rocca; Roberto Gradini; Daniela Melchiorri; Ferdinando Nicoletti
The mGlu5 metabotropic glutamate receptor is expressed in zones of active neurogenesis of the embryonic and postnatal brain.
Brain research. Developmental brain research 2004;150(1):17-22.
2004: Luisa Iacovelli; Loredana Capobianco; M Iula; Valeria Di Giorgi Gerevini; Antonietta Picascia; J Blahos; Daniela Melchiorri; Ferdinando Nicoletti; Antonio De Blasi
Regulation of mGlu4 metabotropic glutamate receptor signaling by type-2 G-protein coupled receptor kinase (GRK2).
Molecular pharmacology 2004;65(5):1103-10.
2004: Alessandra Caruso; Valeria Di Giorgi Gerevini; Marzia Castiglione; Fabiana Marinelli; Valentina Tomassini; Carlo Pozzilli; Andrea Caricasole; Valeria Bruno; Francesco Caciagli; A Moretti; Ferdinando Nicoletti; Daniela Melchiorri
Testosterone amplifies excitotoxic damage of cultured oligodendrocytes.
Journal of neurochemistry 2004;88(5):1179-85.
2004: Santina Chiechio; Agata Copani; Daniela Melchiorri; A M Teixido Canudas; marianna storto; Menotti Calvani; R Nicolai; Ferdinando Nicoletti
Metabotropic receptors as targets for drugs of potential use in the treatment of neuropathic pain.
Journal of endocrinological investigation 2004;27(6 Suppl):171-6.
2004: Marzia Castiglione; Paola Spinsanti; Luisa Iacovelli; Luisa Lenti; Francesca Martini; Roberto Gradini; Valeria Di Giorgi Gerevini; Andrea Caricasole; Alessandra Caruso; Ruggero De Maria; Ferdinando Nicoletti; Daniela Melchiorri
Activation of Fas receptor is required for the increased formation of the disialoganglioside GD3 in cultured cerebellar granule cells committed to apoptotic death.
Neuroscience 2004;126(4):889-98.
2003: Andrea Caricasole; Teresa Ferraro; Luisa Iacovelli; Eliana Barletta; Alessandra Caruso; Daniela Melchiorri; Georg C Terstappen; Ferdinando Nicoletti
Functional characterization of WNT7A signaling in PC12 cells: interaction with A FZD5 x LRP6 receptor complex and modulation by Dickkopf proteins.
The Journal of biological chemistry 2003;278(39):37024-31.
2003: Sergio Scaccianoce; Francesco Matrisciano; Paola Del Bianco; Andrea Caricasole; Valeria Di Giorgi Gerevini; Irene Cappuccio; Daniela Melchiorri; Giuseppe Battaglia; Ferdinando Nicoletti
Endogenous activation of group-II metabotropic glutamate receptors inhibits the hypothalamic-pituitary-adrenocortical axis.
Neuropharmacology 2003;44(5):555-61.
2003: Carlo Cinque; Anna Rita Zuena; Paola Casolini; Richard Teke Ngomba; Daniela Melchiorri; Stefania Maccari; Ferdinando Nicoletti; V Di Giorgi Gerevini; Assia Catalani
Reduced activity of hippocampal group-I metabotropic glutamate receptors in learning-prone rats.
Neuroscience 2003;122(1):277-84.
2002: Andrea Caricasole; Valeria Bruno; Irene Cappuccio; Daniela Melchiorri; Agata Copani; Ferdinando Nicoletti
A novel rat gene encoding a Humanin-like peptide endowed with broad neuroprotective activity.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2002;16(10):1331-3.
2002: Luisa Iacovelli; Valeria Bruno; Lorena Salvatore; Daniela Melchiorri; Roberto Gradini; Andrea Caricasole; Eliana Barletta; Antonio De Blasi; Ferdinando Nicoletti
Native group-III metabotropic glutamate receptors are coupled to the mitogen-activated protein kinase/phosphatidylinositol-3-kinase pathways.
Journal of neurochemistry 2002;82(2):216-23.
2002: Francesco Matrisciano; marianna storto; Richard Teke Ngomba; Irene Cappuccio; Andrea Caricasole; Sergio Scaccianoce; Barbara Riozzi; Daniela Melchiorri; Ferdinando Nicoletti
Imipramine treatment up-regulates the expression and function of mGlu2/3 metabotropic glutamate receptors in the rat hippocampus.
Neuropharmacology 2002;42(8):1008-15.
2002: Daniela Melchiorri; Francesca Martini; Emanuela Lococo; Roberto Gradini; Eliana Barletta; Ruggero De Maria; Andrea Caricasole; Ferdinando Nicoletti; Luisa Lenti
An early increase in the disialoganglioside GD3 contributes to the development of neuronal apoptosis in culture.
Cell death and differentiation 2002;9(6):609-15.
2002: Agata Copani; Daniela Melchiorri; Andrea Caricasole; Francesca Martini; sale Patrizio; Roberto Carnevale; Roberto Gradini; Maria Angela Sortino; Luisa Lenti; Ruggero De Maria; Ferdinando Nicoletti
Beta-amyloid-induced synthesis of the ganglioside GD3 is a requisite for cell cycle reactivation and apoptosis in neurons.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2002;22(10):3963-8.
2002: Santina Chiechio; Andrea Caricasole; Eliana Barletta; marianna storto; Maria Vincenza Catania; Agata Copani; M Vertechy; R Nicolai; Menotti Calvani; Daniela Melchiorri; Ferdinando Nicoletti
L-Acetylcarnitine induces analgesia by selectively up-regulating mGlu2 metabotropic glutamate receptors.
Molecular pharmacology 2002;61(5):989-96.
2002: Giuseppe Battaglia; Francesco Fornai; Carla L Busceti; Gabriella Aloisi; Franca Cerrito; Antonio De Blasi; Daniela Melchiorri; Ferdinando Nicoletti
Selective blockade of mGlu5 metabotropic glutamate receptors is protective against methamphetamine neurotoxicity.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2002;22(6):2135-41.
2001: Valeria Bruno; Giuseppe Battaglia; Agata Copani; Mara D'Onofrio; Patrizia Di Iorio; Antonio De Blasi; Daniela Melchiorri; Peter J Flor; Ferdinando Nicoletti
Metabotropic glutamate receptor subtypes as targets for neuroprotective drugs.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2001;21(9):1013-33.
2001: Daniela Melchiorri; Valeria Bruno; Gilbert Besong; Richard Teke Ngomba; Laura Cuomo; Antonio De Blasi; Agata Copani; CM Moschella; marianna storto; Ferdinando Nicoletti; G Lepperdinger; Francesca Passarelli
The mammalian homologue of the novel peptide Bv8 is expressed in the central nervous system and supports neuronal survival by activating the MAP kinase/PI-3-kinase pathways.
The European journal of neuroscience 2001;13(9):1694-702.