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Jesper Melchjorsen

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Kristy A Horan; Marie B Iversen; Martin R Jakobsen; Evelyn Kurt-Jones; Santo Landolfo; Jesper Melchjorsen; Andrew G Bowie; Blossom Damania; Svend Ellermann-Eriksen; Katherine A Fitzgerald; Kathrine Hansen; Christian K Holm; Simon B Rasmussen; Stine Søby; Mikayla Thompson; Leonie Unterholzner; John A West; Søren R Paludan
Proteasomal degradation of herpes simplex virus capsids in macrophages releases DNA to the cytosol for recognition by DNA sensors.
Jesper Melchjorsen
Learning from the messengers: innate sensing of viruses and cytokine regulation of immunity - clues for treatments and vaccines.
Anni A Winckelmann; Thomas J Hjelholt; Jesper Melchjorsen; David Montefiori; Lærke V Munk-Petersen; Lars Ostergaard; Thomas A Rasmussen; Ole S Søgaard; Martin Roelsgaard Jakobsen
Administration of a Toll-Like Receptor 9 Agonist Decreases the Proviral Reservoir in Virologically Suppressed HIV-Infected Patients.

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All Publications

2013: Kristy A Horan; Marie B Iversen; Martin R Jakobsen; Evelyn Kurt-Jones; Santo Landolfo; Jesper Melchjorsen; Andrew G Bowie; Blossom Damania; Svend Ellermann-Eriksen; Katherine A Fitzgerald; Kathrine Hansen; Christian K Holm; Simon B Rasmussen; Stine Søby; Mikayla Thompson; Leonie Unterholzner; John A West; Søren R Paludan
Proteasomal degradation of herpes simplex virus capsids in macrophages releases DNA to the cytosol for recognition by DNA sensors.
Journal of immunology (Baltimore, Md. : 1950) 2013;190(5):2311-9.
2013: Jesper Melchjorsen
Learning from the messengers: innate sensing of viruses and cytokine regulation of immunity - clues for treatments and vaccines.
Viruses 2013;5(2):470-527.
2013: Anni A Winckelmann; Thomas J Hjelholt; Jesper Melchjorsen; David Montefiori; Lærke V Munk-Petersen; Lars Ostergaard; Thomas A Rasmussen; Ole S Søgaard; Martin Roelsgaard Jakobsen
Administration of a Toll-Like Receptor 9 Agonist Decreases the Proviral Reservoir in Virologically Suppressed HIV-Infected Patients.
PloS one 2013;8(4):e62074.
2013: Elisabeth A Diget; Rune R Laursen; Jesper Melchjorsen; Stine Søby; Kaja Zuwala; Lars Ostergaard; Randi K Berg; Trine H Mogensen
Characterization of HIV-1 infection and innate sensing in different types of primary human monocyte-derived macrophages.
Mediators of inflammation 2013;2013():208412.
2012: Line Vibholm; Lars Ostergaard; Søren R Paludan; Line S Reinert; Ole S Søgaard; Martin Roelsgaard Jakobsen; Jesper Melchjorsen
Antiviral and immunological effects of tenofovir microbicide in vaginal herpes simplex virus 2 infection.
AIDS research and human retroviruses 2012;28(11):1404-11.
2012: Rasmus Offersen; Søren R Paludan; Martin Roelsgaard Jakobsen; Lars Ostergaard; Jesper Melchjorsen; Ole S Søgaard
TLR9-adjuvanted pneumococcal conjugate vaccine induces antibody-independent memory responses in HIV-infected adults.
Human vaccines & immunotherapeutics 2012;8(8):1042-7.
2012: Katrine M Jensen; Rune R Laursen; Jesper Melchjorsen; Ole S Søgaard; Uffe B S Sørensen; Frederik Dagnaes-Hansen; Lars Østergaard; Martin Tolstrup
Timing of Toll-like receptor 9 agonist administration in pneumococcal vaccination impacts both humoral and cellular immune responses as well as nasopharyngeal colonization in mice.
Infection and immunity 2012;80(5):1744-52.
2012: Jesper Melchjorsen
Sensing herpes: more than toll.
Reviews in medical virology 2012;22(2):106-21.
2012: Stine Søby; Lars Ostergaard; Rune R Laursen; Jesper Melchjorsen
HSV-1-induced chemokine expression via IFI16-dependent and IFI16-independent pathways in human monocyte-derived macrophages.
Herpesviridae 2012;3(1):6.
2011: Jesper Melchjorsen; Hans Minderman; Kieran L O'Loughlin; Søren R Paludan; Michael W Risør; Ole S Søgaard; Sue Chow; Svend Ellermann-Eriksen; David W Hedley; Lars Ostergaard; Martin Tolstrup
Tenofovir selectively regulates production of inflammatory cytokines and shifts the IL-12/IL-10 balance in human primary cells.
Journal of acquired immune deficiency syndromes (1999) 2011;57(4):265-75.
2011: Thomas A Rasmussen; Martin Roelsgaard Jakobsen; Lars Ostergaard; Christian A Frederiksen; Bente L Langdahl; Jesper Melchjorsen; Ulla S Nielsen; Alex L Laursen
Evaluation of cardiovascular biomarkers in HIV-infected patients switching to abacavir or tenofovir based therapy.
BMC infectious diseases 2011;11():267.
2011: Tea Kirkegaard; Jesper Melchjorsen; Lars Ostergaard; Finn S Pedersen; Damian F J Purcell; Shervin Bahrami; Robert J Center; Mogens Duch; Adam Wheatley; Martin Roelsgaard Jakobsen
Induction of humoral and cellular immune responses against the HIV-1 envelope protein using γ-retroviral virus-like particles.
Virology journal 2011;8():381.
2011: Anne Roslev Bukh; Jens Magnus Bernth Jensen; Jesper Melchjorsen; Rasmus Offersen; Lars Ostergaard; Henrik Støvring; Lars Toft; Martin Roelsgaard Jakobsen; Ole Schmeltz Søgaard
Endotoxemia is associated with altered innate and adaptive immune responses in untreated HIV-1 infected individuals.
PloS one 2011;6(6):e21275.
2010: Jesper Melchjorsen; Johanna Rintahaka; Stine Søby; Kristy A Horan; Alina Poltajainen; Lars Østergaard; Søren R Paludan; Sampsa Matikainen
Early innate recognition of herpes simplex virus in human primary macrophages is mediated via the MDA5/MAVS-dependent and MDA5/MAVS/RNA polymerase III-independent pathways.
Journal of virology 2010;84(21):11350-8.
2010: Marie B Iversen; Nina Ank; Jesper Melchjorsen; Søren R Paludan
Expression of type III interferon (IFN) in the vaginal mucosa is mediated primarily by dendritic cells and displays stronger dependence on NF-kappaB than type I IFNs.
Journal of virology 2010;84(9):4579-86.
2010: Tiina Ohman; Niina Lietzén; Elina Välimäki; Jesper Melchjorsen; Sampsa Matikainen; Tuula A Nyman
Cytosolic RNA recognition pathway activates 14-3-3 protein mediated signaling and caspase-dependent disruption of cytokeratin network in human keratinocytes.
Journal of proteome research 2010;9(3):1549-64.
2010: Trine H Mogensen; Jesper Melchjorsen; Carsten S Larsen; Søren R Paludan
Innate immune recognition and activation during HIV infection.
Retrovirology 2010;7():54.
2009: Jesper Melchjorsen; Sampsa Matikainen; Søren R Paludan
Activation and evasion of innate antiviral immunity by herpes simplex virus.
Viruses 2009;1(3):737-59.
2009: Susie S Mikkelsen; Søren B Jensen; Srikanth Chiliveru; Jesper Melchjorsen; Ilkka Julkunen; Matthias Gaestel; J Simon C Arthur; Richard A Flavell; Sankar Ghosh; Søren R Paludan
RIG-I-mediated activation of p38 MAPK is essential for viral induction of interferon and activation of dendritic cells: dependence on TRAF2 and TAK1.
The Journal of biological chemistry 2009;284(16):10774-82.
2009: Jesper Melchjorsen; Helle Kristiansen; Rune Christiansen; Johanna Rintahaka; Sampsa Matikainen; Søren R Paludan; Rune Hartmann
Differential regulation of the OASL and OAS1 genes in response to viral infections.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 2009;29(4):199-207.
2009: C Dellgren; H H Gad; O J Hamming; Jesper Melchjorsen; R Hartmann
Human interferon-lambda3 is a potent member of the type III interferon family.
Genes and immunity 2009;10(2):125-31.
2006: Jesper Melchjorsen; Jukka Sirén; Ilkka Julkunen; Søren R Paludan; Sampsa Matikainen
Induction of cytokine expression by herpes simplex virus in human monocyte-derived macrophages and dendritic cells is dependent on virus replication and is counteracted by ICP27 targeting NF-kappaB and IRF-3.
The Journal of general virology 2006;87(Pt 5):1099-108.
2005: Jesper Melchjorsen; Søren B Jensen; Lene Malmgaard; Simon B Rasmussen; Friedemann Weber; Andrew G Bowie; Sampsa Matikainen; Søren R Paludan
Activation of innate defense against a paramyxovirus is mediated by RIG-I and TLR7 and TLR8 in a cell-type-specific manner.
Journal of virology 2005;79(20):12944-51.
2004: Lene Malmgaard; Jesper Melchjorsen; Andrew G Bowie; Søren Mogensen; Søren R Paludan
Viral activation of macrophages through TLR-dependent and -independent pathways.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(11):6890-8.
2004: Trine H Mogensen; Jesper Melchjorsen; Lene Malmgaard; Antonella Casola; Søren R Paludan
Suppression of proinflammatory cytokine expression by herpes simplex virus type 1.
Journal of virology 2004;78(11):5883-90.
2003: Jesper Melchjorsen; Louise N Sørensen; Søren R Paludan
Expression and function of chemokines during viral infections: from molecular mechanisms to in vivo function.
Journal of leukocyte biology 2003;74(3):331-43.
2003: Jesper Melchjorsen; Søren R Paludan
Induction of RANTES/CCL5 by herpes simplex virus is regulated by nuclear factor kappa B and interferon regulatory factor 3.
The Journal of general virology 2003;84(Pt 9):2491-5.
2003: Trine H Mogensen; Jesper Melchjorsen; Per Höllsberg; Søren R Paludan
Activation of NF-kappa B in virus-infected macrophages is dependent on mitochondrial oxidative stress and intracellular calcium: downstream involvement of the kinases TGF-beta-activated kinase 1, mitogen-activated kinase/extracellular signal-regulated kinase kinase 1, and I kappa B kinase.
Journal of immunology (Baltimore, Md. : 1950) 2003;170(12):6224-33.
2002: Søren R Paludan; Jesper Melchjorsen; Lene Malmgaard; Søren Mogensen
Expression of genes for cytokines and cytokine-related functions in leukocytes infected with Herpes simplex virus: comparison between resistant and susceptible mouse strains.
European cytokine network 2002;13(3):306-16.
2002: Jesper Melchjorsen; Finn Skou Pedersen; Søren Mogensen; Søren R Paludan
Herpes simplex virus selectively induces expression of the CC chemokine RANTES/CCL5 in macrophages through a mechanism dependent on PKR and ICP0.
Journal of virology 2002;76(6):2780-8.