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William Melega

Research Profile

Procedures

Tomography, Emission-Computed

Chemicals & Drugs

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Animal Behavior

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Amit P Mulgaonkar; Rahul S Singh; Meghedi Babakhanian; Alexander Bystritsky; Martin O Culjat; Antonio A F De Salles; Alessandra Gorgulho; Warren S Grundfest; Goran Lacan; William P Melega
A prototype stimulator system for noninvasive Low Intensity Focused Ultrasound delivery.
William P Melega; Eric J Behnke; Alessandra Gorgulho; Goran Lacan; Antonio A F De Salles
Hypothalamic deep brain stimulation reduces weight gain in an obesity-animal model.
Alexander Bystritsky; Mark S Cohen; Antonio A F DeSalles; Pamela K Douglas; Alex S Korb; William P Melega; Byoung-Kyong Min; Amit P Mulgaonkar; Seung-Schik Yoo
A review of low-intensity focused ultrasound pulsation.

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2012: Amit P Mulgaonkar; Rahul S Singh; Meghedi Babakhanian; Alexander Bystritsky; Martin O Culjat; Antonio A F De Salles; Alessandra Gorgulho; Warren S Grundfest; Goran Lacan; William P Melega
A prototype stimulator system for noninvasive Low Intensity Focused Ultrasound delivery.
Studies in health technology and informatics 2012;173():297-303.
2012: William P Melega; Eric J Behnke; Alessandra Gorgulho; Goran Lacan; Antonio A F De Salles
Hypothalamic deep brain stimulation reduces weight gain in an obesity-animal model.
PloS one 2012;7(1):e30672.
2011: Alexander Bystritsky; Mark S Cohen; Antonio A F DeSalles; Pamela K Douglas; Alex S Korb; William P Melega; Byoung-Kyong Min; Amit P Mulgaonkar; Seung-Schik Yoo
A review of low-intensity focused ultrasound pulsation.
Brain stimulation 2011;4(3):125-36.
2011: Jing Yong; Goran Lacan; Hoa Dang; Terry Hsieh; Blake Middleton; clive wasserfall; Jide Tian; William P Melega; Daniel L Kaufman
BCG vaccine-induced neuroprotection in a mouse model of Parkinson's disease.
PloS one 2011;6(1):e16610.
2009: Ronald Kuczenski; David S Segal; William P Melega; Goran Lacan; Stanley J McCunney
Human methamphetamine pharmacokinetics simulated in the rat: behavioral and neurochemical effects of a 72-h binge.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2009;34(11):2430-41.
2009: Scott C Fears; William P Melega; Susan K Service; Chris Lee; Kelly Chen; Zhuowen Tu; Matthew J Jorgensen; Lynn A Fairbanks; Rita M Cantor; Nelson B Freimer; Roger P Woods
Identifying heritable brain phenotypes in an extended pedigree of vervet monkeys.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2009;29(9):2867-75.
2008: Shaoying Lee; Hongyu Deng; Fuqu Yu; William P Melega; Robert Damoiseaux; Kenneth A Bradley; Ren Sun
Regulation of Kaposi's sarcoma-associated herpesvirus reactivation by dopamine receptor-mediated signaling pathways.
Journal of acquired immune deficiency syndromes (1999) 2008;48(5):531-40.
2008: William P Melega; Matthew J Jorgensen; Goran Laćan; Baldwin M Way; Jamie Pham; Grenvill Morton; Arthur K Cho; Lynn A Fairbanks
Long-term methamphetamine administration in the vervet monkey models aspects of a human exposure: brain neurotoxicity and behavioral profiles.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2008;33(6):1441-52.
2008: Goran Laćan; Antonio A F De Salles; Alessandra Gorgulho; Scott Krahl; Leonardo Frighetto; Eric J Behnke; William P Melega
Modulation of food intake following deep brain stimulation of the ventromedial hypothalamus in the vervet monkey. Laboratory investigation.
Journal of neurosurgery 2008;108(2):336-42.
2008: Mark Chin; Wei-Jun Qian; Haixing Wang; Vladislav A Petyuk; Joshua S Bloom; Daniel M Sforza; Goran Laćan; Dahai Liu; Arshad H Khan; Rita M Cantor; Diana J Bigelow; William P Melega; David G Camp; Richard D Smith; Desmond J Smith
Mitochondrial dysfunction, oxidative stress, and apoptosis revealed by proteomic and transcriptomic analyses of the striata in two mouse models of Parkinson's disease.
Journal of proteome research 2008;7(2):666-77.
2007: William P Melega; Goran Laćan; Dennis C Harvey; Baldwin M Way
Methamphetamine increases basal ganglia iron to levels observed in aging.
Neuroreport 2007;18(16):1741-5.
2007: Baldwin M Way; G Laćan; Lynn A Fairbanks; William P Melega
Architectonic distribution of the serotonin transporter within the orbitofrontal cortex of the vervet monkey.
Neuroscience 2007;148(4):937-48.
2007: William P Melega; Arthur K Cho; Dennis Harvey; Goran Laćan
Methamphetamine blood concentrations in human abusers: application to pharmacokinetic modeling.
Synapse (New York, N.Y.) 2007;61(4):216-20.
2006: Meghan L O'Neil; Ronald Kuczenski; David S Segal; Arthur K Cho; Goran Lacan; William P Melega
Escalating dose pretreatment induces pharmacodynamic and not pharmacokinetic tolerance to a subsequent high-dose methamphetamine binge.
Synapse (New York, N.Y.) 2006;60(6):465-73.
2006: Colette A Sacksteder; Wei-Jun Qian; Tatyana V Knyushko; Haixing Wang; Mark Chin; Goran Lacan; William P Melega; David G Camp; Richard D Smith; Desmond J Smith; Thomas C Squier; Diana J Bigelow
Endogenously nitrated proteins in mouse brain: links to neurodegenerative disease.
Biochemistry 2006;45(26):8009-22.
2005: David S Segal; Ronald Kuczenski; Meghan L O'Neil; William P Melega; Arthur K Cho
Prolonged exposure of rats to intravenous methamphetamine: behavioral and neurochemical characterization.
Psychopharmacology 2005;180(3):501-12.
2004: Timothy D Solberg; Steven J Goetsch; Michael T Selch; William P Melega; Goran Lacan; Antonio A F DeSalles
Functional stereotactic radiosurgery involving a dedicated linear accelerator and gamma unit: a comparison study.
Journal of neurosurgery 2004;101 Suppl 3():373-80.
2003: Daniel J Rubins; William P Melega; Goran Lacan; Baldwin M Way; Alain Plenevaux; André Luxen; Simon R Cherry
Development and evaluation of an automated atlas-based image analysis method for microPET studies of the rat brain.
NeuroImage 2003;20(4):2100-18.
2003: Antonio A F De Salles; Leonardo Frighetto; Goran Lacan; William P Melega
Radiosurgery can achieve precision needed for functional neurosurgery.
Archives of neurology 2003;60(10):1494-6; author reply 1496.
2003: David S Segal; Ronald Kuczenski; Meghan L O'Neil; William P Melega; Arthur K Cho
Escalating dose methamphetamine pretreatment alters the behavioral and neurochemical profiles associated with exposure to a high-dose methamphetamine binge.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2003;28(10):1730-40.
2002: Shuang Zheng; Alice H Chou; Amie L Jimenez; Omid Khodadadi; Sarah Son; William P Melega; Bruce D Howard
The fetal and neonatal brain protein neuronatin protects PC12 cells against certain types of toxic insult.
Brain research. Developmental brain research 2002;136(2):101-10.
2002: Vanessa M Brown; Alex Ossadtchi; Arshad H Khan; Simon Yee; Goran Lacan; William P Melega; Simon R Cherry; Richard M Leahy; Desmond J Smith
Multiplex three-dimensional brain gene expression mapping in a mouse model of Parkinson's disease.
Genome research 2002;12(6):868-84.
2002: Arthur K Cho; William P Melega
Patterns of methamphetamine abuse and their consequences.
Journal of addictive diseases 2002;21(1):21-34.
2001: Antonio A F De Salles; William P Melega; G Laćan; L J Steele; Timothy D Solberg
Radiosurgery performed with the aid of a 3-mm collimator in the subthalamic nucleus and substantia nigra of the vervet monkey.
Journal of neurosurgery 2001;95(6):990-7.
2001: Daniel J Rubins; A Ken Meadors; Simon Yee; William P Melega; Simon R Cherry
Evaluation of a stereotactic frame for repositioning of the rat brain in serial positron emission tomography imaging studies.
Journal of neuroscience methods 2001;107(1-2):63-70.
2001: LR Baxter; EC Clark; RF Ackermann; Goran Lacan; William P Melega
Brain mediation of Anolis social dominance displays. II. Differential forebrain serotonin turnover, and effects of specific 5-HT receptor agonists.
Brain, behavior and evolution 2001;57(4):184-201.
2001: Lynn A Fairbanks; William P Melega; Matthew J Jorgensen; Jay R Kaplan; M T McGuire
Social impulsivity inversely associated with CSF 5-HIAA and fluoxetine exposure in vervet monkeys.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2001;24(4):370-8.
2001: Arthur K Cho; William P Melega; Ronald Kuczenski; David S Segal
Relevance of pharmacokinetic parameters in animal models of methamphetamine abuse.
Synapse (New York, N.Y.) 2001;39(2):161-6.
2000: Dennis C Harvey; Goran Lacan; S P Tanious; William P Melega
Recovery from methamphetamine induced long-term nigrostriatal dopaminergic deficits without substantia nigra cell loss.
Brain research 2000;871(2):259-70.
2000: Alain Plenevaux; Christian Lemaire; Joël Aerts; Goran Lacan; Daniel J Rubins; William P Melega; C Brihaye; Christian Degueldre; S Fuchs; Eric Salmon; Pierre Maquet; steven laureys; Philippe Damhaut; D Weissmann; Didier Le Bars; Jean-François Pujol; André Luxen
[(18)F]p-MPPF: aA radiolabeled antagonist for the study of 5-HT(1A) receptors with PET.
Nuclear medicine and biology 2000;27(5):467-71.
2000: William P Melega; Goran Lacan; Antonio A F DeSalles; Michael E Phelps
Long-term methamphetamine-induced decreases of [(11)C]WIN 35,428 binding in striatum are reduced by GDNF: PET studies in the vervet monkey.
Synapse (New York, N.Y.) 2000;35(4):243-9.
1999: Arthur K Cho; William P Melega; Ronald Kuczenski; David S Segal; Debra A Schmitz
Caudate-putamen dopamine and stereotypy response profiles after intravenous and subcutaneous amphetamine.
Synapse (New York, N.Y.) 1999;31(2):125-33.
1999: William P Melega; Arthur K Cho; Debra A Schmitz; Ronald Kuczenski; David S Segal
l-methamphetamine pharmacokinetics and pharmacodynamics for assessment of in vivo deprenyl-derived l-methamphetamine.
The Journal of pharmacology and experimental therapeutics 1999;288(2):752-8.
1998: William P Melega; Goran Lacan; Dennis C Harvey; Sung-Cheng Huang; Michael E Phelps
Dizocilpine and reduced body temperature do not prevent methamphetamine-induced neurotoxicity in the vervet monkey: [11C]WIN 35,428 - positron emission tomography studies.
Neuroscience letters 1998;258(1):17-20.
1998: David B Stout; Sung-Cheng Huang; William P Melega; MJ Raleigh; Michael E Phelps; Jorge R Barrio
Effects of large neutral amino acid concentrations on 6-[F-18]Fluoro-L-DOPA kinetics.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 1998;18(1):43-51.
1997: William P Melega; MJ Raleigh; David B Stout; Goran Lacan; Sung-Cheng Huang; Michael E Phelps
Recovery of striatal dopamine function after acute amphetamine- and methamphetamine-induced neurotoxicity in the vervet monkey.
Brain research 1997;766(1-2):113-20.
1997: Ronald Kuczenski; William P Melega; Arthur K Cho; David S Segal
Extracellular dopamine and amphetamine after systemic amphetamine administration: comparison to the behavioral response.
The Journal of pharmacology and experimental therapeutics 1997;282(2):591-6.
1997: William P Melega; MJ Raleigh; David B Stout; Sung-Cheng Huang; Michael E Phelps
Ethological and 6-[18F]fluoro-L-DOPA-PET profiles of long-term vulnerability to chronic amphetamine.
Behavioural brain research 1997;84(1-2):259-68.
1996: K P Lin; Sung-Cheng Huang; D C Yu; William P Melega; Jorge R Barrio; Michael E Phelps
Automated image registration for FDOPA PET studies.
Physics in medicine and biology 1996;41(12):2775-88.
1996: William P Melega; MJ Raleigh; David B Stout; Antonio A F DeSalles; Simon R Cherry; Mathew Blurton-Jones; G G Morton; Sung-Cheng Huang; Michael E Phelps
Longitudinal behavioral and 6-[18F]fluoro-L-DOPA-PET assessment in MPTP-hemiparkinsonian monkeys.
Experimental neurology 1996;141(2):318-29.
1996: Jorge R Barrio; Sung-Cheng Huang; D C Yu; William P Melega; Javier Quintana; Simon R Cherry; A Jacobson; Mohammad Namavari; Nagichettiar Satyamurthy; Michael E Phelps
Radiofluorinated L-m-tyrosines: new in-vivo probes for central dopamine biochemistry.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 1996;16(4):667-78.
1996: William P Melega; Javier Quintana; MJ Raleigh; David B Stout; D C Yu; K P Lin; Sung-Cheng Huang; Michael E Phelps
6-[18F]fluoro-L-DOPA-PET studies show partial reversibility of long-term effects of chronic amphetamine in monkeys.
Synapse (New York, N.Y.) 1996;22(1):63-9.
1995: William P Melega; A E Williams; Debra A Schmitz; E W DiStefano; Arthur K Cho
Pharmacokinetic and pharmacodynamic analysis of the actions of D-amphetamine and D-methamphetamine on the dopamine terminal.
The Journal of pharmacology and experimental therapeutics 1995;274(1):90-6.
1995: R Kuczenski; D S Segal; A K Cho; William P Melega
Hippocampus norepinephrine, caudate dopamine and serotonin, and behavioral responses to the stereoisomers of amphetamine and methamphetamine.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1995;15(2):1308-17.
1993: D C Yu; Sung-Cheng Huang; Scott T Grafton; William P Melega; Jorge R Barrio; John C Mazziotta; Michael E Phelps
Methods for improving quantitation of putamen uptake constant of FDOPA in PET studies.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 1993;34(4):679-88.
1992: J M Hoffman; William P Melega; T C Hawk; S C Grafton; A Luxen; D K Mahoney; Jorge R Barrio; Sung-Cheng Huang; John C Mazziotta; Michael E Phelps
The effects of carbidopa administration on 6-[18F]fluoro-L-dopa kinetics in positron emission tomography.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 1992;33(8):1472-7.
1992: A Luxen; M Guillaume; William P Melega; V W Pike; O Solin; R Wagner
Production of 6-[18F]fluoro-L-dopa and its metabolism in vivo--a critical review.
International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology 1992;19(2):149-58.
1991: Sung-Cheng Huang; D C Yu; Jorge R Barrio; Scott T Grafton; William P Melega; J M Hoffman; Nagichettiar Satyamurthy; John C Mazziotta; Michael E Phelps
Kinetics and modeling of L-6-[18F]fluoro-dopa in human positron emission tomographic studies.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 1991;11(6):898-913.
1991: William P Melega; Scott T Grafton; Sung-Cheng Huang; Nagichettiar Satyamurthy; Michael E Phelps; Jorge R Barrio
L-6-[18F]fluoro-dopa metabolism in monkeys and humans: biochemical parameters for the formulation of tracer kinetic models with positron emission tomography.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 1991;11(6):890-7.
1991: Sung-Cheng Huang; Jorge R Barrio; D C Yu; B Chen; Scott T Grafton; William P Melega; J M Hoffman; Nagichettiar Satyamurthy; John C Mazziotta; Michael E Phelps
Modelling approach for separating blood time-activity curves in positron emission tomographic studies.
Physics in medicine and biology 1991;36(6):749-61.
1991: William P Melega; J M Hoffman; Jay S Schneider; Michael E Phelps; Jorge R Barrio
6-[18F]fluoro-L-dopa metabolism in MPTP-treated monkeys: assessment of tracer methodologies for positron emission tomography.
Brain research 1991;543(2):271-6.
1990: Jorge R Barrio; Sung-Cheng Huang; William P Melega; D C Yu; J M Hoffman; Jay S Schneider; Nagichettiar Satyamurthy; John C Mazziotta; Michael E Phelps
6-[18F]fluoro-L-dopa probes dopamine turnover rates in central dopaminergic structures.
Journal of neuroscience research 1990;27(4):487-93.
1990: William P Melega; A Luxen; M M Perlmutter; C H Nissenson; Michael E Phelps; Jorge R Barrio
Comparative in vivo metabolism of 6-[18F]fluoro-L-dopa and [3H]L-dopa in rats.
Biochemical pharmacology 1990;39(12):1853-60.
1990: William P Melega; J M Hoffman; A Luxen; C H Nissenson; Michael E Phelps; Jorge R Barrio
The effects of carbidopa on the metabolism of 6-[18F]fluoro-L-dopa in rats, monkeys and humans.
Life sciences 1990;47(2):149-57.
1989: William P Melega; M M Perlmutter; A Luxen; C H Nissenson; Scott T Grafton; Sung-Cheng Huang; Michael E Phelps; Jorge R Barrio
4-[18F]fluoro-L-m-tyrosine: an L-3,4-dihydroxyphenylalanine analog for probing presynaptic dopaminergic function with positron emission tomography.
Journal of neurochemistry 1989;53(1):311-4.