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Ignacio Melero

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Ignacio Melero; Aizea Morales-Kastresana; Miguel F Sanmamed; Daniel Hirschhorn-Cymerman; Jedd D Wolchok
Agonist antibodies to TNFR molecules that costimulate T and NK cells.
Ignacio Melero; Jose Luis Perez-Gracia; Antonio M Grimaldi; Paolo A Ascierto
Clinical development of immunostimulatory monoclonal antibodies and opportunities for combination.
Maria C Ochoa; Pedro Berraondo; Miguel F de Sanmamed; Sandra Hervas-Stubbs; Guillermo Mazzolini; Ignacio Melero
Interleukin-15 in gene therapy of cancer.

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2013: Ignacio Melero; Aizea Morales-Kastresana; Miguel F Sanmamed; Daniel Hirschhorn-Cymerman; Jedd D Wolchok
Agonist antibodies to TNFR molecules that costimulate T and NK cells.
Clinical cancer research : an official journal of the American Association for Cancer Research 2013;19(5):1044-53.
2013: Ignacio Melero; Jose Luis Perez-Gracia; Antonio M Grimaldi; Paolo A Ascierto
Clinical development of immunostimulatory monoclonal antibodies and opportunities for combination.
Clinical cancer research : an official journal of the American Association for Cancer Research 2013;19(5):997-1008.
2013: Maria C Ochoa; Pedro Berraondo; Miguel F de Sanmamed; Sandra Hervas-Stubbs; Guillermo Mazzolini; Ignacio Melero
Interleukin-15 in gene therapy of cancer.
Current gene therapy 2013;13(1):15-30.
2013: Maria C Ochoa; Julian Pardo; Jesus Prieto; Inmaculada Rodriguez; Arantza Azpilikueta; Pedro Berraondo; Jessica Fioravanti; Alfonso Gúrpide; Sandra Hervas-Stubbs; Guillermo Mazzolini; Ignacio Melero
Antitumor immunotherapeutic and toxic properties of an HDL-conjugated chimeric IL-15 fusion protein.
Cancer research 2013;73(1):139-49.
2012: Sandra Hervas-Stubbs; Ana Larraga; Esther Larrea; Agnes Le Bon; Jose Maria Lopez-Picazo; Uxua Mancheño; Salvador Martín Algarra; Aizea Morales-Kastresana; Maria C Ochoa; Hanspeter Pircher; Jesus Prieto; José I Riezu-Boj; Carlos Alfaro; Diego Alignani; Iranzu Gonzalez; Ignacio Melero
CD8 T cell priming in the presence of IFN-α renders CTLs with improved responsiveness to homeostatic cytokines and recall antigens: important traits for adoptive T cell therapy.
Journal of immunology (Baltimore, Md. : 1950) 2012;189(7):3299-310.
2012: José I Quetglas; Miguel F Sanmamed; Cristian Smerdou; Jaione Bezunartea; Juan Dubrot; Sandra Hervas-Stubbs; Ignacio Melero
Immunotherapeutic synergy between anti-CD137 mAb and intratumoral administration of a cytopathic Semliki Forest virus encoding IL-12.
Molecular therapy : the journal of the American Society of Gene Therapy 2012;20(9):1664-75.
2012: Álvaro Teijeira; Cristina Aubá; Saray Garasa; François Lang; Diego Marré; Iván Martínez-Forero; Ignacio Melero; Oihana Murillo; Asís Palazón; Anne Rogel; Ana Rouzaut
CD137 on inflamed lymphatic endothelial cells enhances CCL21-guided migration of dendritic cells.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2012;26(8):3380-92.
2012: Asís Palazón; Iván Peñuelas; Jose Luis Perez-Gracia; Ana Rouzaut; Miguel F Sanmamed; Alvaro Teijeira; Manuel O Landázuri; Carlos Alfaro; Julián Aragonés; Sandra Hervás-Stubbs; Maria Jure-Kunkel; Iván Martínez-Forero; Aizea Morales-Kastresana; Ignacio Melero
The HIF-1α hypoxia response in tumor-infiltrating T lymphocytes induces functional CD137 (4-1BB) for immunotherapy.
Cancer discovery 2012;2(7):608-23.
2012: Maria C Ochoa; Asis Palazon; Jesus Prieto; Aizea Morales-Kastresana; Oihana Murillo; Carlos Alfaro; Ainhoa Arina; Pedro Berraondo; Juan Dubrot; Erwin H Duitman; Jessica Fioravanti; Sandra Hervas-Stubbs; Jose Medina-Echeverz; Ignacio Melero
Liver gene transfer of interkeukin-15 constructs that become part of circulating high density lipoproteins for immunotherapy.
PloS one 2012;7(12):e52370.
2012: Carmen Unzu; Carlos Alfaro; Stuart G Beattie; Alberto Benito; Rafael Enríquez de Salamanca; Sandra Hervás-Stubbs; Uxua Mancheño; Itsaso Mauleón; Ignacio Melero; Harald Petry; Jesús Prieto; Ana Sampedro; Antonio Fontanellas
Transient and intensive pharmacological immunosuppression fails to improve AAV-based liver gene transfer in non-human primates.
Journal of translational medicine 2012;10():122.
2012: Ivan Martinez Forero; Thomas F Gajewski; Alan J Korman; Hideho Okada; Suzanne Topalian; Ignacio Melero
Workshop on immunotherapy combinations. Society for Immunotherapy of Cancer annual meeting Bethesda, November 3, 2011.
Journal of translational medicine 2012;10():108.
2011: Carlos Alfaro; Alberto Benito; Elixabet Bolaños; Alfonso Calvo; Miguel Fernandez de Sanmamed; Alvaro Gonzalez; Sandra Hervás-Stubbs; Salvador Martin-Algarra; Ivan Martinez-Forero; Iván Peñuelas; Javier Perez-Calvo; Jose Luis Perez-Gracia; Miriam Redrado; José Richter; Inmaculada Rodriguez; Javier Rodriguez; Bruno Sangro; Natalia Suarez; Carmen Vigil; Alice Agliano; Ignacio Melero
Pilot clinical trial of type 1 dendritic cells loaded with autologous tumor lysates combined with GM-CSF, pegylated IFN, and cyclophosphamide for metastatic cancer patients.
Journal of immunology (Baltimore, Md. : 1950) 2011;187(11):6130-42.
2011: Natalia Suarez; Aizea Morales-Kastresana; Asis Palazon; Jose Luis Perez-Gracia; Bruno Sangro; Carlos Alfaro; Elixabet Bolaños; Juan Dubrot; Lorena Erro; Alvaro Gonzalez; Sandra Hervas-Stubbs; Fernando Lecanda; Salvador Martin-Algarra; Ivan Martinez-Forero; Ignacio Melero
Synergistic effects of CTLA-4 blockade with tremelimumab and elimination of regulatory T lymphocytes in vitro and in vivo.
International journal of cancer. Journal international du cancer 2011;129(2):374-86.
2011: Maria C Ochoa; Sandra Hervas-Stubbs; Asis Palazon; Ivan Martinez-Forero; Pedro Berraondo; Pablo Sarobe; Alan Melcher; Ignacio Melero
International symposium on CTL and immunostimulation, Pamplona (Spain), October 26th and 27th 2010.
Cancer immunology, immunotherapy : CII 2011;60(5):753-6.
2011: Sandra Hervas-Stubbs; Jose Luis Perez-Gracia; Ana Rouzaut; Miguel F Sanmamed; Agnes Le Bon; Ignacio Melero
Direct effects of type I interferons on cells of the immune system.
Clinical cancer research : an official journal of the American Association for Cancer Research 2011;17(9):2619-27.
2011: Asís Palazón; Alvaro Teijeira; Iván Martínez-Forero; Sandra Hervás-Stubbs; Carmen Roncal; Iván Peñuelas; Juan Dubrot; Aizea Morales-Kastresana; José Luis Pérez-Gracia; M Carmen Ochoa; Laura Ochoa; Alfredo Martínez; Alfonso Luque; Joseph Dinchuk; Ana Rouzaut; Maria Jure-Kunkel; Ignacio Melero
Agonist anti-CD137 mAb act on tumor endothelial cells to enhance recruitment of activated T lymphocytes.
Cancer research 2011;71(3):801-11.
2011: Carlos Alfaro; Natalia Suárez; Ivan Martínez-Forero; Asís Palazón; Ana Rouzaut; Sarai Solano; Esperanza Feijoo; Alfonso Gúrpide; Elixabet Bolaños; Lorena Erro; Juan Dubrot; Sandra Hervás-Stubbs; Alvaro Gonzalez; Jose Luis Perez-Gracia; Ignacio Melero
Carcinoma-derived interleukin-8 disorients dendritic cell migration without impairing T-cell stimulation.
PloS one 2011;6(3):e17922.
2011: Juan Dubrot; Asis Palazón; Carlos Alfaro; Arantza Azpilikueta; María Carmen Ochoa; Ana Rouzaut; Iván Martinez-Forero; Alvaro Teijeira; Pedro Berraondo; Agnes Le Bon; Sandra Hervás-Stubbs; Ignacio Melero
Intratumoral injection of interferon-α and systemic delivery of agonist anti-CD137 monoclonal antibodies synergize for immunotherapy.
International journal of cancer. Journal international du cancer 2011;128(1):105-18.
2010: Sandra Hervas-Stubbs; José I Riezu-Boj; Iranzu Gonzalez; Uxua Mancheño; Juan Dubrot; Arantza Azpilicueta; Izaskun Gabari; Asis Palazon; Alicia Aranguren; Juan Ruiz; Jesus Prieto; Esther Larrea; Ignacio Melero
Effects of IFN-α as a signal-3 cytokine on human naïve and antigen-experienced CD8(+) T cells.
European journal of immunology 2010;40(12):3389-402.
2010: Ana Rouzaut; Saray Garasa; Alvaro Teijeira; Iranzu González; Ivan Martinez-Forero; Natalia Suarez; Esther Larrea; Carlos Alfaro; Asís Palazón; Juan Dubrot; Sandra Hervás-Stubbs; Ignacio Melero
Dendritic cells adhere to and transmigrate across lymphatic endothelium in response to IFN-α.
European journal of immunology 2010;40(11):3054-63.
2010: Juan Dubrot; Aitziber Portero; Gorka Orive; Rosa María Hernández; Asis Palazón; Ana Rouzaut; Jose L Perez-Gracia; Sandra Hervás-Stubbs; Jose Luis Pedraz; Ignacio Melero
Delivery of immunostimulatory monoclonal antibodies by encapsulated hybridoma cells.
Cancer immunology, immunotherapy : CII 2010;59(11):1621-31.
2010: Juan Dubrot; Francisca Milheiro; Carlos Alfaro; Asis Palazón; Ivan Martinez-Forero; Jose L Perez-Gracia; Aizea Morales-Kastresana; José L Romero-Trevejo; María C Ochoa; Sandra Hervás-Stubbs; Jesús Prieto; Maria Jure-Kunkel; Lieping Chen; Ignacio Melero
Treatment with anti-CD137 mAbs causes intense accumulations of liver T cells without selective antitumor immunotherapeutic effects in this organ.
Cancer immunology, immunotherapy : CII 2010;59(8):1223-33.
2010: Antonio Fontanellas; Sandra Hervás-Stubbs; Itsaso Mauleón; Juan Dubrot; Uxua Mancheño; María Collantes; Ana Sampedro; Carmen Unzu; Carlos Alfaro; Asis Palazón; Cristian Smerdou; Alberto Benito; Jesús Prieto; Iván Peñuelas; Ignacio Melero
Intensive pharmacological immunosuppression allows for repetitive liver gene transfer with recombinant adenovirus in nonhuman primates.
Molecular therapy : the journal of the American Society of Gene Therapy 2010;18(4):754-65.
2010: Cristian Smerdou; Carmen Ochoa; Jose I Quetglas; Antonio Fontanellas; Gloria Gonzalez-Aseguinolaza; Richard G Vile; Ignacio Melero
Immunology and gene therapy: shoulder to shoulder into the fray.
Molecular therapy : the journal of the American Society of Gene Therapy 2010;18(3):456-9.
2010: Carmen Unzu; Ana Sampedro; Itsaso Mauleón; Lucía Vanrell; Juan Dubrot; Rafael Enríquez de Salamanca; Gloria González-Aseguinolaza; Ignacio Melero; Jesús Prieto; Antonio Fontanellas
Porphobilinogen deaminase over-expression in hepatocytes, but not in erythrocytes, prevents accumulation of toxic porphyrin precursors in a mouse model of acute intermittent porphyria.
Journal of hepatology 2010;52(3):417-24.
2009: J L Perez-Gracia; C Prior; francisco guillen grima; Victor Segura; A Gonzalez; Angel Panizo; Ignacio Melero; E Grande-Pulido; Alfonso Gurpide; Ignacio Gil-Bazo; Alfonso Calvo
Identification of TNF-alpha and MMP-9 as potential baseline predictive serum markers of sunitinib activity in patients with renal cell carcinoma using a human cytokine array.
British journal of cancer 2009;101(11):1876-83.
2009: Ivan Martinez-Forero; Ana Rouzaut; Asis Palazon; Juan Dubrot; Ignacio Melero
Lysine 63 polyubiquitination in immunotherapy and in cancer-promoting inflammation.
Clinical cancer research : an official journal of the American Association for Cancer Research 2009;15(22):6751-7.
2009: Jose L Perez-Gracia; Pedro Berraondo; Ivan Martinez-Forero; Carlos Alfaro; Natalia Suarez; Alfonso Gurpide; Bruno Sangro; Sandra Hervas-Stubbs; Carmen Ochoa; Jose A Melero; Ignacio Melero
Clinical development of combination strategies in immunotherapy: are we ready for more than one investigational product in an early clinical trial?
Immunotherapy 2009;1(5):845-53.
2009: Oihana Murillo; Juan Dubrot; Asís Palazón; Ainhoa Arina; Arantza Azpilikueta; Carlos Alfaro; Sarai Solano; María C Ochoa; Carmen Berasain; Izaskun Gabari; Jose L Pérez-Gracia; Pedro Berraondo; Sandra Hervás-Stubbs; Ignacio Melero
In vivo depletion of DC impairs the anti-tumor effect of agonistic anti-CD137 mAb.
European journal of immunology 2009;39(9):2424-36.
2009: Ignacio Melero; Ivan Martinez-Forero; Juan Dubrot; Natalia Suarez; Asis Palazón; Lieping Chen
Palettes of vaccines and immunostimulatory monoclonal antibodies for combination.
Clinical cancer research : an official journal of the American Association for Cancer Research 2009;15(5):1507-9.
2009: A Fontanellas; Sandra Hervas-Stubbs; A Sampedro; María Collantes; Arantza Azpilicueta; I Mauleón; A Pañeda; G Quincoces; Jesús Prieto; Ignacio Melero; Iván Peñuelas
PET imaging of thymidine kinase gene expression in the liver of non-human primates following systemic delivery of an adenoviral vector.
Gene therapy 2009;16(1):136-41.
2008: Pablo Villoslada; Beatriz Moreno; Ignacio Melero; Jose L Pablos; Gianvito Martino; Antonio Uccelli; Xavier Montalban; Jesús Avila; Serge Rivest; Laia Acarin; Stanley Appel; Samia J Khoury; Patrick L McGeer; Isidro Ferrer; Mario Delgado; Jose A Obeso; Michal Schwartz
Immunotherapy for neurological diseases.
Clinical immunology (Orlando, Fla.) 2008;128(3):294-305.
2008: Ignacio Melero; Oihana Murillo; Juan Dubrot; Sandra Hervás-Stubbs; José L Perez-Gracia
Multi-layered action mechanisms of CD137 (4-1BB)-targeted immunotherapies.
Trends in pharmacological sciences 2008;29(8):383-90.
2008: Ainhoa Arina; Oihana Murillo; Juan Dubrot; A Azpilikueta; Izaskun Gabari; J L Perez-Gracia; Carlos Alfaro; Carmen Berasain; Jesús Prieto; S Ferrini; Sandra Hervas-Stubbs; Ignacio Melero
Interleukin-15 liver gene transfer increases the number and function of IKDCs and NK cells.
Gene therapy 2008;15(7):473-83.
2008: Ivan Martinez-Forero; Ricardo Garcia-Munoz; Sara Martinez-Pasamar; Susana Inoges; Ascensión Lopez-Diaz de Cerio; Ricardo Palacios; Jorge Sepulcre; Beatriz Moreno; Zaira Gonzalez; Begoña Fernandez-Diez; Ignacio Melero; Maurizio Bendandi; Pablo Villoslada
IL-10 suppressor activity and ex vivo Tr1 cell function are impaired in multiple sclerosis.
European journal of immunology 2008;38(2):576-86.
2007: Manuel Rodriguez; Lydia Alvarez-Erviti; Francisco J Blesa; María C Rodríguez-Oroz; Ainhoa Arina; Ignacio Melero; Luís Isaac Ramos; Jose A Obeso
Bone-marrow-derived cell differentiation into microglia: a study in a progressive mouse model of Parkinson's disease.
Neurobiology of disease 2007;28(3):316-25.
2007: Guillermo Mazzolini; Oihana Murillo; Catalina Atorrasagasti; Juan Dubrot; Iñigo Tirapu; Miguel Rizzo; Ainhoa Arina; Carlos Alfaro; Arantza Azpilicueta; Carmen Berasain; José L Perez-Gracia; Alvaro Gonzalez; Ignacio Melero
Immunotherapy and immunoescape in colorectal cancer.
World journal of gastroenterology : WJG 2007;13(44):5822-31.
2007: Ainhoa Arina; Oihana Murillo; Sandra Hervás-Stubbs; Arantza Azpilikueta; Juan Dubrot; Iñigo Tirapu; Eduardo Huarte; Carlos Alfaro; Jose L Pérez-Gracia; Gloria González-Aseguinolaza; Pablo Sarobe; Juan José Lasarte; Amanda Jamieson; Jesús Prieto; David H Raulet; Ignacio Melero
The combined actions of NK and T lymphocytes are necessary to reject an EGFP+ mesenchymal tumor through mechanisms dependent on NKG2D and IFN gamma.
International journal of cancer. Journal international du cancer 2007;121(6):1282-95.
2007: J L Pérez-Gracia; José María López-Picazo; C Olier; Carlos Alfaro; Jesús García-Foncillas; Ignacio Melero; A Gúrpide
[New treatments for renal carcinoma].
Anales del sistema sanitario de Navarra 2007;30(3):393-403.
2007: Pedro Redondo; Julio del Olmo; Ascensión López-Diaz de Cerio; Susana Inoges; Miren Marquina; Ignacio Melero; Maurizio Bendandi
Imiquimod enhances the systemic immunity attained by local cryosurgery destruction of melanoma lesions.
The Journal of investigative dermatology 2007;127(7):1673-80.
2007: Ainhoa Arina; Oihana Murillo; Juan Dubrot; Arantza Azpilikueta; Carlos Alfaro; Jose L Pérez-Gracia; Maurizio Bendandi; Belen Palencia; Sandra Hervás-Stubbs; Ignacio Melero
Cellular liaisons of natural killer lymphocytes in immunology and immunotherapy of cancer.
Expert opinion on biological therapy 2007;7(5):599-615.
2007: Ignacio Melero; Sandra Hervas-Stubbs; Martin J Glennie; Drew M Pardoll; Lieping Chen
Immunostimulatory monoclonal antibodies for cancer therapy.
Nature reviews. Cancer 2007;7(2):95-106.
2007: Ricardo Palacios; Joaquin Goni; Ivan Martinez-Forero; Jaime Iranzo; Jorge Sepulcre; Ignacio Melero; Pablo Villoslada
A network analysis of the human T-cell activation gene network identifies JAGGED1 as a therapeutic target for autoimmune diseases.
PloS one 2007;2(11):e1222.
2006: Susana Inogès; Mercedes Rodrìguez-Calvillo; Natalia Zabalegui; Ascensiòn Lòpez-Dìaz de Cerio; Helena Villanueva; Elena Soria; Lilia Suárez; Arancha Rodríguez-Caballero; Fernando Pastor; Ricardo García-Muñóz; Carlos Panizo; Javier Pèrez-Calvo; Ignacio Melero; Eduardo Rocha; Alberto Orfao; Maurizio Bendandi
Clinical benefit associated with idiotypic vaccination in patients with follicular lymphoma.
Journal of the National Cancer Institute 2006;98(18):1292-301.
2006: Eduardo Huarte; Esther Larrea; Rubén Hernández-Alcoceba; Carlos Alfaro; Oihana Murillo; Ainhoa Arina; Iñigo Tirapu; Arantza Azpilicueta; Sandra Hervás-Stubbs; Sergia Bortolanza; Jose L Pérez-Gracia; Maria Pilar Civeira; Jesús Prieto; José I Riezu-Boj; Ignacio Melero
Recombinant adenoviral vectors turn on the type I interferon system without inhibition of transgene expression and viral replication.
Molecular therapy : the journal of the American Society of Gene Therapy 2006;14(1):129-38.
2006: Ignacio Melero; Ainhoa Arina; Oihana Murillo; Juan Dubrot; Carlos Alfaro; Jose L Pérez-Gracia; Maurizio Bendandi; Sandra Hervás-Stubbs
Immunogenic cell death and cross-priming are reaching the clinical immunotherapy arena.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(8):2385-9.
2006: Iñigo Tirapu; Eduardo Huarte; Cristiana Guiducci; Ainhoa Arina; Mikel Zaratiegui; Oihana Murillo; Alvaro Gonzalez; Carmen Berasain; Pedro Berraondo; Puri Fortes; Jesús Prieto; Mario P Colombo; Lieping Chen; Ignacio Melero
Low surface expression of B7-1 (CD80) is an immunoescape mechanism of colon carcinoma.
Cancer research 2006;66(4):2442-50.
2006: Carlos Alfaro; Oihana Murillo; Iñigo Tirapu; Arantza Azpilicueta; Eduardo Huarte; Ainhoa Arina; Laura Arribillaga; Jose L Pérez-Gracia; Maurizio Bendandi; Jesús Prieto; Juan José Lasarte; Ignacio Melero
[The immunotherapy potential of agonistic anti-CD137 (4-1BB) monoclonal antibodies for malignancies and chronic viral diseases].
Anales del sistema sanitario de Navarra 2006;29(1):77-96.
2005: Bruno Sangro; Ignacio Melero; Cheng Qian; Jesus Prieto
Gene therapy of cancer based on interleukin 12.
Current gene therapy 2005;5(6):573-81.
2005: Maria Vera; Nerea Razquin; Jesús Prieto; Ignacio Melero; Puri Fortes; Gloria González-Aseguinolaza
Intratumoral injection of dendritic cells transduced by an SV40-based vector expressing interleukin-15 induces curative immunity mediated by CD8+ T lymphocytes and NK cells.
Molecular therapy : the journal of the American Society of Gene Therapy 2005;12(5):950-9.
2005: Esperanza Feijoó; Carlos Alfaro; Guillermo Mazzolini; Patricia Serra; Iván Peñuelas; Ainhoa Arina; Eduardo Huarte; Iñigo Tirapu; Belen Palencia; Oihana Murillo; Juan Ruiz; Bruno Sangro; José A Richter; Jesús Prieto; Ignacio Melero
Dendritic cells delivered inside human carcinomas are sequestered by interleukin-8.
International journal of cancer. Journal international du cancer 2005;116(2):275-81.
2005: Laura Arribillaga; Pablo Sarobe; Ainhoa Arina; Marta Gorraiz; Francisco Borrás-Cuesta; Juan Ruiz; Jesús Prieto; Lieping Chen; Ignacio Melero; Juan José Lasarte
Enhancement of CD4 and CD8 immunity by anti-CD137 (4-1BB) monoclonal antibodies during hepatitis C vaccination with recombinant adenovirus.
Vaccine 2005;23(27):3493-9.
2005: Guillermo Mazzolini; Carlos Alfaro; Bruno Sangro; Esperanza Feijoó; Juan Ruiz; Alberto Benito; Iñigo Tirapu; Ainhoa Arina; Josu Sola; Maite Herraiz; Felipe Lucena; Cristina Olagüe; Jose Carlos Subtil; Jorge Quiroga; Ignacio Herrero; Belén Sádaba; Maurizio Bendandi; Cheng Qian; Jesús Prieto; Ignacio Melero
Intratumoral injection of dendritic cells engineered to secrete interleukin-12 by recombinant adenovirus in patients with metastatic gastrointestinal carcinomas.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2005;23(5):999-1010.
2005: Ignacio Melero; Ainhoa Arina; Lieping Chen
The many sounds of T lymphocyte silence.
Immunologic research 2005;33(2):135-47.
2005: Eduardo Huarte; Iñigo Tirapu; Ainhoa Arina; Maria Vera; Carlos Alfaro; Oihana Murillo; Belen Palencia; Victoria Busto; Verónica Marín; Guillermo Mazzolini; Ignacio Melero
Intratumoural administration of dendritic cells: hostile environment and help by gene therapy.
Expert opinion on biological therapy 2005;5(1):7-22.
2004: Mercedes Rodríguez-Calvillo; Susana Inogés; Ascensión López-Díaz de Cerio; Natalia Zabalegui; Carlos Panizo; Milagros Hernández; Javier Pérez-Calvo; Felipe Prósper; Ignacio Melero; Alfonso Sánchez-Ibarrola; Eduardo Rocha; Maurizio Bendandi
[Past, present and future of anti-idiotype vaccination].
Revista de medicina de la Universidad de Navarra 2004;48(3):14-23.
2004: Iñigo Tirapu; Ainhoa Arina; Guillermo Mazzolini; Marina Duarte; Carlos Alfaro; Esperanza Feijoo; Cheng Qian; Lieping Chen; Jesus Prieto; Ignacio Melero
Improving efficacy of interleukin-12-transfected dendritic cells injected into murine colon cancer with anti-CD137 monoclonal antibodies and alloantigens.
International journal of cancer. Journal international du cancer 2004;110(1):51-60.
2004: Bruno Sangro; Guillermo Mazzolini; Juan Ruiz; Maite Herraiz; Jorge Quiroga; Ignacio Herrero; Alberto Benito; Javier Larrache; Jesus Pueyo; Jose Carlos Subtil; Cristina Olagüe; Josu Sola; Belén Sádaba; Carlos Lacasa; Ignacio Melero; Cheng Qian; Jesus Prieto
Phase I trial of intratumoral injection of an adenovirus encoding interleukin-12 for advanced digestive tumors.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2004;22(8):1389-97.
2004: Jesus Prieto; Cheng Qian; Bruno Sangro; Ignacio Melero; Guillermo Mazzolini
Biologic therapy of liver tumors.
The Surgical clinics of North America 2004;84(2):673-96.
2004: Susana Inogés; Mercedes Rodríguez-Calvillo; Ascensión López-Díaz de Cerio; Natalia Zabalegui; Ignacio Melero; Alfonso Sánchez-Ibarrola; Eduardo Rocha; Maurizio Bendandi
[Active immunotherapy in the treatment of haematological neoplasias].
Anales del sistema sanitario de Navarra 2004;27(1):45-62.
2004: Guillermo Mazzolini; Ignacio Melero; Jesús Prieto
[Role of interleukin-12 in cancer immunotherapy].
Medicina 2004;64(1):77-8.
2004: Pablo Sarobe; Esperanza Feijoó; Carlos Alfaro; Guillermo Mazzolini; Ignacio Melero
MAGE antigens: therapeutic targets in hepatocellular carcinoma?
Journal of hepatology 2004;40(1):155-8.
2003: Noelia Casares; Laura Arribillaga; Pablo Sarobe; Javier Dotor; Ascensión Lopez-Diaz de Cerio; Ignacio Melero; Jesús Prieto; Francisco Borrás-Cuesta; Juan José Lasarte
CD4+/CD25+ regulatory cells inhibit activation of tumor-primed CD4+ T cells with IFN-gamma-dependent antiangiogenic activity, as well as long-lasting tumor immunity elicited by peptide vaccination.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(11):5931-9.
2003: Oihana Murillo; Ainhoa Arina; Iñigo Tirapu; Carlos Alfaro; Guillermo Mazzolini; Belen Palencia; Ascensión López-Diaz De Cerio; Jesús Prieto; Maurizio Bendandi; Ignacio Melero
Potentiation of therapeutic immune responses against malignancies with monoclonal antibodies.
Clinical cancer research : an official journal of the American Association for Cancer Research 2003;9(15):5454-64.
2003: Pablo Sarobe; Juan José Lasarte; Aintzane Zabaleta; Laura Arribillaga; Ainhoa Arina; Ignacio Melero; Francisco Borrás-Cuesta; Jesús Prieto
Hepatitis C virus structural proteins impair dendritic cell maturation and inhibit in vivo induction of cellular immune responses.
Journal of virology 2003;77(20):10862-71.
2003: Ignacio Melero; Izaskun Gabari; Iñigo Tirapu; Ainhoa Arina; Guillermo Mazzolini; Elena Baixeras; Esperanza Feijoo; Carlos Alfaro; Cheng Qian; Jesús Prieto
Anti-ICAM-2 monoclonal antibody synergizes with intratumor gene transfer of interleukin-12 inhibiting activation-induced T-cell death.
Clinical cancer research : an official journal of the American Association for Cancer Research 2003;9(10 Pt 1):3546-54.
2003: Guillermo Mazzolini; Inigo Narvaiza; L A Martinez-Cruz; Ainhoa Arina; Miguel Barajas; JC Galofré; Cheng Qian; José M Mato; Jesús Prieto; Ignacio Melero
Pancreatic cancer escape variants that evade immunogene therapy through loss of sensitivity to IFNgamma-induced apoptosis.
Gene therapy 2003;10(13):1067-78.
2003: Jesús Prieto; Maite Herraiz; Bruno Sangro; Cheng Qian; Guillermo Mazzolini; Ignacio Melero; Juan Ruiz
The promise of gene therapy in gastrointestinal and liver diseases.
Gut 2003;52 Suppl 2():ii49-54.
2003: Guillermo Mazzolini; Jesús Prieto; Ignacio Melero
Gene therapy of cancer with interleukin-12.
Current pharmaceutical design 2003;9(24):1981-91.
2002: Ainhoa Arina; Iñigo Tirapu; Carlos Alfaro; Mercedes Rodríguez-Calvillo; Guillermo Mazzolini; Susana Inogés; Ascensión López; Esperanza Feijoo; Maurizio Bendandi; Ignacio Melero
Clinical implications of antigen transfer mechanisms from malignant to dendritic cells. exploiting cross-priming.
Experimental hematology 2002;30(12):1355-64.
2002: Ignacio Melero; Izaskun Gabari; Angel L Corbí; Miguel Relloso; Guillermo Mazzolini; Volker Schmitz; Mercedes Rodriguez-Calvillo; Iñigo Tirapu; Emilio Camafeita; Juan Pablo Albar; Jesús Prieto
An anti-ICAM-2 (CD102) monoclonal antibody induces immune-mediated regressions of transplanted ICAM-2-negative colon carcinomas.
Cancer research 2002;62(11):3167-74.
2002: Mercedes Rodríguez-Calvillo; Marina Duarte; Iñigo Tirapu; Pedro Berraondo; Guillermo Mazzolini; Cheng Qian; Jesús Prieto; Ignacio Melero
Upregulation of natural killer cells functions underlies the efficacy of intratumorally injected dendritic cells engineered to produce interleukin-12.
Experimental hematology 2002;30(3):195-204.
2002: Iñigo Tirapu; Mercedes Rodriguez-Calvillo; Cheng Qian; Marina Duarte; Cristian Smerdou; Belen Palencia; Guillermo Mazzolini; Jesús Prieto; Ignacio Melero
Cytokine gene transfer into dendritic cells for cancer treatment.
Current gene therapy 2002;2(1):79-89.
2002: Iñigo Tirapu; Guillermo Mazzolini; Mercedes Rodriguez-Calvillo; Ainhoa Arina; Belen Palencia; Izaskun Gabari; Ignacio Melero
Effective tumor immunotherapy: start the engine, release the brakes, step on the gas pedal,...and get ready to face autoimmunity.
Archivum immunologiae et therapiae experimentalis 2002;50(1):13-8.
2002: Volker Schmitz; Cheng Qian; Juan Ruiz; Bruno Sangro; Ignacio Melero; Guillermo Mazzolini; Inigo Narvaiza; Jesús Prieto
Gene therapy for liver diseases: recent strategies for treatment of viral hepatitis and liver malignancies.
Gut 2002;50(1):130-5.
2001: Noelia Casares; Juan José Lasarte; Ascensión López-Díaz de Cerio; Pablo Sarobe; Marta Ruiz; Ignacio Melero; Jesús Prieto; Francisco Borrás-Cuesta
Immunization with a tumor-associated CTL epitope plus a tumor-related or unrelated Th1 helper peptide elicits protective CTL immunity.
European journal of immunology 2001;31(6):1780-9.
2001: J Prieto; Cheng Qian; Ignacio Melero; Bruno Sangro; Guillermo Mazzolini; Inigo Narvaiza; Miguel Barajas
Gene therapy of primary and metastatic liver tumors.
Medical science monitor : international medical journal of experimental and clinical research 2001;7 Suppl 1():76-7.
2001: Mercedes Rodríguez-Calvillo; Izaskun Gabari; Marina Duarte; Guillermo Mazzolini; José Rifón; Eduardo Rocha; Jesús Prieto; Ignacio Melero
Thrombopenic purpura induced by a monoclonal antibody directed to a 35-kilodalton surface protein (p35) expressed on murine platelets and endothelial cells.
Experimental hematology 2001;29(5):589-95.
2001: Guillermo Mazzolini; Inigo Narvaiza; Matilde Bustos; Marina Duarte; Iñigo Tirapu; R Bilbao; Cheng Qian; Jesús Prieto; Ignacio Melero
Alpha(v)beta(3) integrin-mediated adenoviral transfer of interleukin-12 at the periphery of hepatic colon cancer metastases induces VCAM-1 expression and T-cell recruitment.
Molecular therapy : the journal of the American Society of Gene Therapy 2001;3(5 Pt 1):665-72.
2001: Ignacio Melero; Guillermo Mazzolini; Inigo Narvaiza; Cheng Qian; Lieping Chen; J Prieto
IL-12 gene therapy for cancer: in synergy with other immunotherapies.
Trends in immunology 2001;22(3):113-5.
2001: Guillermo Mazzolini; Inigo Narvaiza; A Pérez-Diez; Mercedes Rodriguez-Calvillo; Cheng Qian; Bruno Sangro; Juan Ruiz; Jesús Prieto; Ignacio Melero
Genetic heterogeneity in the toxicity to systemic adenoviral gene transfer of interleukin-12.
Gene therapy 2001;8(4):259-67.
2001: Miguel Barajas; Guillermo Mazzolini; G Genové; R Bilbao; Inigo Narvaiza; Volker Schmitz; Bruno Sangro; Ignacio Melero; Cheng Qian; Jesús Prieto
Gene therapy of orthotopic hepatocellular carcinoma in rats using adenovirus coding for interleukin 12.
Hepatology (Baltimore, Md.) 2001;33(1):52-61.
2000: Ignacio Melero; R G Vile; M P Colombo
Feeding dendritic cells with tumor antigens: self-service buffet or à la carte?
Gene therapy 2000;7(14):1167-70.
2000: Inigo Narvaiza; Guillermo Mazzolini; Miguel Barajas; Marina Duarte; Mikel Zaratiegui; Cheng Qian; Ignacio Melero; Jesús Prieto
Intratumoral coinjection of two adenoviruses, one encoding the chemokine IFN-gamma-inducible protein-10 and another encoding IL-12, results in marked antitumoral synergy.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(6):3112-22.
2000: Guillermo Mazzolini; Cheng Qian; Inigo Narvaiza; Miguel Barajas; Francisco Borrás-Cuesta; X Xie; Marina Duarte; Ignacio Melero; Jesús Prieto
Adenoviral gene transfer of interleukin 12 into tumors synergizes with adoptive T cell therapy both at the induction and effector level.
Human gene therapy 2000;11(1):113-25.
1999: Ignacio Melero; Marina Duarte; Juan Ruiz; Bruno Sangro; JC Galofré; Guillermo Mazzolini; Matilde Bustos; Cheng Qian; Jesús Prieto
Intratumoral injection of bone-marrow derived dendritic cells engineered to produce interleukin-12 induces complete regression of established murine transplantable colon adenocarcinomas.
Gene therapy 1999;6(10):1779-84.