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Gunn Iren Meling

Research Profile

Disorders

Chemicals & Drugs

Physiology

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Genes & Molecular Sequences

Procedures

DNA Mutational Analysis

Anatomy

Chromosomes, Human, Pair 17

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Anita Sveen; Trude H Ågesen; Knut Liestøl; Gunn Iren Meling; Arild Nesbakken; Torleiv O Rognum; Rolf Skotheim; Ragnhild A Lothe
ColoGuidePro: a prognostic 7-gene expression signature for stage III colorectal cancer patients.
Solveig Sirnes; Hilde Honne; Deeqa Ahmed; Stine Aske Danielsen; Torleiv O Rognum; Gunn Iren Meling; Edward Leithe; Edgar Rivedal; Ragnhild A Lothe; Guro E Lind
DNA methylation analyses of the connexin gene family reveal silencing of GJC1 (Connexin45) by promoter hypermethylation in colorectal cancer.
Guro E Lind; Terje Ahlquist; Kim Andresen; Michael Bretthauer; Stine A Danielsen; Merete Hektoen; Geir Hoff; Gunn Iren Meling; Marianne A Merok; Arild Nesbakken; Torleiv O Rognum; Rolf Skotheim; Espen Thiis-Evensen; Ragnhild A Lothe
Identification of an epigenetic biomarker panel with high sensitivity and specificity for colorectal cancer and adenomas.

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All Publications

2012: Anita Sveen; Trude H Ågesen; Knut Liestøl; Gunn Iren Meling; Arild Nesbakken; Torleiv O Rognum; Rolf Skotheim; Ragnhild A Lothe
ColoGuidePro: a prognostic 7-gene expression signature for stage III colorectal cancer patients.
Clinical cancer research : an official journal of the American Association for Cancer Research 2012;18(21):6001-10.
2011: Solveig Sirnes; Hilde Honne; Deeqa Ahmed; Stine Aske Danielsen; Torleiv O Rognum; Gunn Iren Meling; Edward Leithe; Edgar Rivedal; Ragnhild A Lothe; Guro E Lind
DNA methylation analyses of the connexin gene family reveal silencing of GJC1 (Connexin45) by promoter hypermethylation in colorectal cancer.
Epigenetics : official journal of the DNA Methylation Society 2011;6(5):602-9.
2011: Guro E Lind; Terje Ahlquist; Kim Andresen; Michael Bretthauer; Stine A Danielsen; Merete Hektoen; Geir Hoff; Gunn Iren Meling; Marianne A Merok; Arild Nesbakken; Torleiv O Rognum; Rolf Skotheim; Espen Thiis-Evensen; Ragnhild A Lothe
Identification of an epigenetic biomarker panel with high sensitivity and specificity for colorectal cancer and adenomas.
Molecular cancer 2011;10():85.
2008: Stine A Danielsen; Guro E Lind; Merete Bjørnslett; Gunn Iren Meling; Torleiv O Rognum; Sverre Heim; Ragnhild A Lothe
Novel mutations of the suppressor gene PTEN in colorectal carcinomas stratified by microsatellite instability- and TP53 mutation- status.
Human mutation 2008;29(11):E252-62.
2008: Terje Ahlquist; Irene Bottillo; Stine A Danielsen; Gunn Iren Meling; Torleiv O Rognum; Guro E Lind; Bruno Dallapiccola; Ragnhild A Lothe
RAS signaling in colorectal carcinomas through alteration of RAS, RAF, NF1, and/or RASSF1A.
Neoplasia (New York, N.Y.) 2008;10(7):680-6, 2 p following 686.
2008: Terje Ahlquist; Guro E Lind; Vera L Costa; Gunn Iren Meling; Morten Vatn; Geir S Hoff; Torleiv O Rognum; Rolf Skotheim; Espen Thiis-Evensen; Ragnhild A Lothe
Gene methylation profiles of normal mucosa, and benign and malignant colorectal tumors identify early onset markers.
Molecular cancer 2008;7():94.
2007: Kristine Kleivi; Guro E Lind; Chieu B Diep; Gunn Iren Meling; Lin T Brandal; Jahn M Nesland; Ola Myklebost; Torleiv O Rognum; Karl-Erik Giercksky; Rolf Skotheim; Ragnhild A Lothe
Gene expression profiles of primary colorectal carcinomas, liver metastases, and carcinomatoses.
Molecular cancer 2007;6():2.
2006: Guro E Lind; Kristine Kleivi; Gunn Iren Meling; Manuel Teixeira; Espen Thiis-Evensen; Torleiv O Rognum; Ragnhild A Lothe
ADAMTS1, CRABP1, and NR3C1 identified as epigenetically deregulated genes in colorectal tumorigenesis.
Cellular oncology : the official journal of the International Society for Cellular Oncology 2006;28(5-6):259-72.
2005: Guttorm Guleng; Tone Løvig; Gunn Iren Meling; Solveig Norheim Andersen; Torleiv O Rognum
Mitochondrial microsatellite instability in colorectal carcinomas--frequency and association with nuclear microsatellite instability.
Cancer letters 2005;219(1):97-103.
2005: Lin Thorstensen; Guro E Lind; Tone Løvig; Chieu B Diep; Gunn Iren Meling; Torleiv O Rognum; Ragnhild A Lothe
Genetic and epigenetic changes of components affecting the WNT pathway in colorectal carcinomas stratified by microsatellite instability.
Neoplasia (New York, N.Y.) 2005;7(2):99-108.
2004: Guro E Lind; Lin Thorstensen; Tone Løvig; Gunn Iren Meling; Richard Hamelin; Torleiv O Rognum; Manel Esteller; Ragnhild A Lothe
A CpG island hypermethylation profile of primary colorectal carcinomas and colon cancer cell lines.
Molecular cancer 2004;3():28.
2004: Hilda Amelia Pickett; Duncan Martin Baird; Per Hoff-Olsen; Gunn Iren Meling; Torleiv O Rognum; Jacqui Shaw; Kevin Paul West; Nicola J Royle
Telomere instability detected in sporadic colon cancers, some showing mutations in a mismatch repair gene.
Oncogene 2004;23(19):3434-43.
2004: Kjersti Flatmark; Gunhild M Maelandsmo; Svein-Ole Mikalsen; Kjell Nustad; Tone Varaas; Heidi Rasmussen; Gunn Iren Meling; Øystein Fodstad; Elisabeth Paus
Immunofluorometric assay for the metastasis-related protein S100A4: release of S100A4 from normal blood cells prohibits the use of S100A4 as a tumor marker in plasma and serum.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2004;25(1-2):31-40.
2003: Chieu B Diep; Lin Thorstensen; Gunn Iren Meling; Eva Skovlund; Torleiv O Rognum; Ragnhild A Lothe
Genetic tumor markers with prognostic impact in Dukes' stages B and C colorectal cancer patients.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2003;21(5):820-9.
2002: Anita Langerød; Ida R K Bukholm; André Bregård; Per Eystein Lønning; Tone Ikdal Andersen; Torleiv O Rognum; Gunn Iren Meling; Ragnhild A Lothe; Anne-Lise Børresen-Dale
The TP53 codon 72 polymorphism may affect the function of TP53 mutations in breast carcinomas but not in colorectal carcinomas.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2002;11(12):1684-8.
2002: Tone Løvig; Gunn Iren Meling; Chieu B Diep; Lin Thorstensen; S Norheim Andersen; Ragnhild A Lothe; Torleiv O Rognum
APC and CTNNB1 mutations in a large series of sporadic colorectal carcinomas stratified by the microsatellite instability status.
Scandinavian journal of gastroenterology 2002;37(10):1184-93.
2002: Tone Løvig; Solveig Norheim Andersen; Lin Thorstensen; Chieu B Diep; Gunn Iren Meling; Ragnhild A Lothe; Torleiv O Rognum
Strong HLA-DR expression in microsatellite stable carcinomas of the large bowel is associated with good prognosis.
British journal of cancer 2002;87(7):756-62.
2001: Lin Thorstensen; Chieu B Diep; Gunn Iren Meling; T H Aagesen; Christian H Ahrens; Torleiv O Rognum; Ragnhild A Lothe
WNT1 inducible signaling pathway protein 3, WISP-3, a novel target gene in colorectal carcinomas with microsatellite instability.
Gastroenterology 2001;121(6):1275-80.
2001: Alex Duval; Barry Iacopetta; Lin Thorstensen; Gunn Iren Meling; Ragnhild A Lothe; B Thuille; Nirosha Suraweera; Gilles Thomas; Richard Hamelin
Gender difference for mismatch repair deficiency in human colorectal cancer.
Gastroenterology 2001;121(4):1026-7.
1998: Ole Petter F Clausen; Ragnhild A Lothe; Anne-Lise Børresen-Dale; Paula M de Angelis; Y Chen; Torleiv O Rognum; Gunn Iren Meling
Association of p53 accumulation with TP53 mutations, loss of heterozygosity at 17p13, and DNA ploidy status in 273 colorectal carcinomas.
Diagnostic molecular pathology : the American journal of surgical pathology, part B 1998;7(4):215-23.
1998: Ragnhild A Lothe; Merete Hektoen; Hilde Johnsen; Gunn Iren Meling; Tone Ikdal Andersen; Torleiv O Rognum; A Lindblom; Anne-Lise Børresen-Dale
The APC gene I1307K variant is rare in Norwegian patients with familial and sporadic colorectal or breast cancer.
Cancer research 1998;58(14):2923-4.
1998: Per Hoff-Olsen; Gunn Iren Meling; Bjørnar Olaisen
Variation in mutation rate and direction between tetranucleotide STR loci in human colorectal carcinomas.
Annals of human genetics 1998;62(Pt 1):1-7.
1998: Anne-Lise Børresen-Dale; Ragnhild A Lothe; Gunn Iren Meling; Pierre Hainaut; Torleiv O Rognum; Eva Skovlund
TP53 and long-term prognosis in colorectal cancer: mutations in the L3 zinc-binding domain predict poor survival.
Clinical cancer research : an official journal of the American Association for Cancer Research 1998;4(1):203-10.
1997: Jarle Breivik; Ragnhild A Lothe; Gunn Iren Meling; Torleiv O Rognum; Anne-Lise Børresen-Dale; Gustav Gaudernack
Different genetic pathways to proximal and distal colorectal cancer influenced by sex-related factors.
International journal of cancer. Journal international du cancer 1997;74(6):664-9.
1997: Solveig Norheim Andersen; Tone Løvig; Jarle Breivik; Eiliv Lund; Gustav Gaudernack; Gunn Iren Meling; Torleiv O Rognum
K-ras mutations and prognosis in large-bowel carcinomas.
Scandinavian journal of gastroenterology 1997;32(1):62-9.
1996: S Norheim Andersen; Jarle Breivik; Tone Løvig; Gunn Iren Meling; Gustav Gaudernack; Ole Petter F Clausen; A Schjölberg; O Fausa; F Langmark; E Lund; Torleiv O Rognum
K-ras mutations and HLA-DR expression in large bowel adenomas.
British journal of cancer 1996;74(1):99-108.
1996: Peter Krajci; Gunn Iren Meling; Solveig Norheim Andersen; Bjørn Hofstad; Morten Vatn; Torleiv O Rognum; Per Brandtzaeg
Secretory component mRNA and protein expression in colorectal adenomas and carcinomas.
British journal of cancer 1996;73(12):1503-10.
1995: A L Børresen; Ragnhild A Lothe; Gunn Iren Meling; S Lystad; Paul Morrison; J Lipford; Michael F Kane; Torleiv O Rognum; Richard D Kolodner
Somatic mutations in the hMSH2 gene in microsatellite unstable colorectal carcinomas.
Human molecular genetics 1995;4(11):2065-72.
1995: Ragnhild A Lothe; Solveig Norheim Andersen; Bjørn Hofstad; Gunn Iren Meling; Päivi Peltomäki; Sverre Heim; A Brøgger; Morten Vatn; Torleiv O Rognum; A L Børresen
Deletion of 1p loci and microsatellite instability in colorectal polyps.
Genes, chromosomes & cancer 1995;14(3):182-8.
1995: Per Hoff-Olsen; Gunn Iren Meling; Bjørnar Olaisen
Somatic mutations in VNTR-locus D1S7 in human colorectal carcinomas are associated with microsatellite instability.
Human mutation 1995;5(4):329-32.
1994: B Fossum; Jarle Breivik; Gunn Iren Meling; T Gedde-Dahl; T Hansen; I Knutsen; Torleiv O Rognum; Erik Thorsby; Gustav Gaudernack
A K-ras 13Gly-->Asp mutation is recognized by HLA-DQ7 restricted T cells in a patient with colorectal cancer. Modifying effect of DQ7 on established cancers harbouring this mutation?
International journal of cancer. Journal international du cancer 1994;58(4):506-11.
1994: Jarle Breivik; Gunn Iren Meling; Anne Spurkland; Torleiv O Rognum; Gustav Gaudernack
K-ras mutation in colorectal cancer: relations to patient age, sex and tumour location.
British journal of cancer 1994;69(2):367-71.
1993: Ragnhild A Lothe; Päivi Peltomäki; Gunn Iren Meling; Lauri A Aaltonen; Minna Nyström-Lahti; Liisa Pylkkänen; Ketil Heimdal; Tone Ikdal Andersen; P Møller; Torleiv O Rognum
Genomic instability in colorectal cancer: relationship to clinicopathological variables and family history.
Cancer research 1993;53(24):5849-52.
1993: Solveig Norheim Andersen; Torleiv O Rognum; E Lund; Gunn Iren Meling; S Hauge
Strong HLA-DR expression in large bowel carcinomas is associated with good prognosis.
British journal of cancer 1993;68(1):80-5.
1993: Gunn Iren Meling; Ragnhild A Lothe; A L Børresen; C Graue; S Hauge; Ole Petter F Clausen; Torleiv O Rognum
The TP53 tumour suppressor gene in colorectal carcinomas. II. Relation to DNA ploidy pattern and clinicopathological variables.
British journal of cancer 1993;67(1):93-8.
1993: Gunn Iren Meling; Ragnhild A Lothe; A L Børresen; C Graue; S Hauge; Ole Petter F Clausen; Torleiv O Rognum
The TP53 tumour suppressor gene in colorectal carcinomas. I. Genetic alterations on chromosome 17.
British journal of cancer 1993;67(1):88-92.
1992: Gunn Iren Meling; Torleiv O Rognum; Ole Petter F Clausen; O Børmer; O C Lunde; Ellen Schlichting; O P Grüner; J Hognestad; Erik Trondsen; O Havig
Serum carcinoembryonic antigen in relation to survival, DNA ploidy pattern, and recurrent disease in 406 colorectal carcinoma patients.
Scandinavian journal of gastroenterology 1992;27(12):1061-8.
1992: Dag Kvale; Jarle Norstein; Gunn Iren Meling; O P Børmer; Per Brandtzaeg; F Langmark; Torleiv O Rognum
Circulating secretory component in relation to early diagnosis and treatment of liver metastasis from colorectal carcinomas.
Journal of clinical pathology 1992;45(7):568-71.
1991: Torleiv O Rognum; E Lund; Gunn Iren Meling; F Langmark
Near diploid large bowel carcinomas have better five-year survival than aneuploid ones.
Cancer 1991;68(5):1077-81.
1991: Gunn Iren Meling; Ragnhild A Lothe; A L Børresen; S Hauge; C Graue; Ole Petter F Clausen; Torleiv O Rognum
Genetic alterations within the retinoblastoma locus in colorectal carcinomas. Relation to DNA ploidy pattern studied by flow cytometric analysis.
British journal of cancer 1991;64(3):475-80.
1991: Gunn Iren Meling; Ole Petter F Clausen; A Bergan; A Schjølberg; Torleiv O Rognum
Flow cytometric DNA ploidy pattern in dysplastic mucosa, and in primary and metastatic carcinomas in patients with longstanding ulcerative colitis.
British journal of cancer 1991;64(2):339-44.
1991: Gunn Iren Meling; Torleiv O Rognum; Ole Petter F Clausen; Y Chen; O C Lunde; Ellen Schlichting; J N Wiig; J Hognestad; Arne Bakka; O Havig
Association between DNA ploidy pattern and cellular atypia in colorectal carcinomas. A new clinical application of DNA flow cytometric study?
Cancer 1991;67(6):1642-9.