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Craig Mello

Research Profile

Chemicals & Drugs

Concepts & Ideas

Genes & Molecular Sequences

Phenomena

RNA Interference

Physiology

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Procedures

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Publications

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Soyoung Kim; Craig C Mello; Rita Sharma; Darryl Conte; Takao Ishidate; Martha C Soto; Masaki Shirayama
Wnt and CDK-1 regulate cortical release of WRM-1/β-catenin to control cell division orientation in early Caenorhabditis elegans embryos.
Andrea D'Ambrogio; Weifeng Gu; Craig C Mello; Tsuyoshi Udagawa; Joel D Richter
Specific miRNA stabilization by Gld2-catalyzed monoadenylation.
Weifeng Gu; Heng-Chi Lee; Daniel Chaves; Darryl Conte; Gregory J Pazour; Elaine M Youngman; Craig C Mello
CapSeq and CIP-TAP identify Pol II start sites and reveal capped small RNAs as C. elegans piRNA precursors.

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All Publications

2013: Soyoung Kim; Craig C Mello; Rita Sharma; Darryl Conte; Takao Ishidate; Martha C Soto; Masaki Shirayama
Wnt and CDK-1 regulate cortical release of WRM-1/β-catenin to control cell division orientation in early Caenorhabditis elegans embryos.
Proceedings of the National Academy of Sciences of the United States of America 2013;110(10):E918-27.
2012: Andrea D'Ambrogio; Weifeng Gu; Craig C Mello; Tsuyoshi Udagawa; Joel D Richter
Specific miRNA stabilization by Gld2-catalyzed monoadenylation.
Cell reports 2012;2(6):1537-45.
2012: Weifeng Gu; Heng-Chi Lee; Daniel Chaves; Darryl Conte; Gregory J Pazour; Elaine M Youngman; Craig C Mello
CapSeq and CIP-TAP identify Pol II start sites and reveal capped small RNAs as C. elegans piRNA precursors.
Cell 2012;151(7):1488-500.
2012: Masaki Shirayama; Meetu Seth; Darryl Conte; Weifeng Gu; Takao Ishidate; Heng-Chi Lee; Craig C Mello
piRNAs initiate an epigenetic memory of nonself RNA in the C. elegans germline.
Cell 2012;150(1):65-77.
2012: Heng-Chi Lee; Darryl Conte; Weifeng Gu; Masaki Shirayama; Elaine Youngman; Craig C Mello
C. elegans piRNAs mediate the genome-wide surveillance of germline transcripts.
Cell 2012;150(1):78-87.
2011: Jun Xie; Qing Xie; Hongwei Zhang; Stefan L Ameres; Jui-Hung Hung; Qin Su; Ran He; Xin Mu; Seemin Seher Ahmed; Soyeon Park; Hiroki Kato; Chengjian Li; Christian Mueller; Craig C Mello; Zhiping Weng; Terence R Flotte; Phillip D Zamore; Guangping Gao
MicroRNA-regulated, systemically delivered rAAV9: a step closer to CNS-restricted transgene expression.
Molecular therapy : the journal of the American Society of Gene Therapy 2011;19(3):526-35.
2011: Weifeng Gu; Craig C Mello; Pedro J Batista; Julie M Claycomb; Darryl Conte
Cloning Argonaute-associated small RNAs from Caenorhabditis elegans.
Methods in molecular biology (Clifton, N.J.) 2011;725():251-80.
2010: Ji Liu; Lisa L Maduzia; Masaki Shirayama; Craig C Mello
NMY-2 maintains cellular asymmetry and cell boundaries, and promotes a SRC-dependent asymmetric cell division.
Developmental biology 2010;339(2):366-73.
2010: Colin C Conine; Pedro J Batista; Weifeng Gu; Julie M Claycomb; Daniel A Chaves; Masaki Shirayama; Craig C Mello
Argonautes ALG-3 and ALG-4 are required for spermatogenesis-specific 26G-RNAs and thermotolerant sperm in Caenorhabditis elegans.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(8):3588-93.
2010: Jessica J Vasale; Weifeng Gu; Caroline Thivierge; Pedro J Batista; Julie M Claycomb; Elaine M Youngman; Thomas F Duchaine; Craig C Mello; Darryl Conte
Sequential rounds of RNA-dependent RNA transcription drive endogenous small-RNA biogenesis in the ERGO-1/Argonaute pathway.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(8):3582-7.
2010: Darryl Conte; Craig C Mello
Primal RNAs: The end of the beginning?
Cell 2010;140(4):452-4.
2009: Weifeng Gu; Masaki Shirayama; Darryl Conte; Jessica Vasale; Pedro J Batista; Julie M Claycomb; James J Moresco; Elaine M Youngman; Jennifer Keys; Matthew J Stoltz; Chun-Chieh G Chen; Daniel A Chaves; Shenghua Duan; Kristin D Kasschau; Noah Fahlgren; John R Yates; Shohei Mitani; James C Carrington; Craig C Mello
Distinct argonaute-mediated 22G-RNA pathways direct genome surveillance in the C. elegans germline.
Molecular cell 2009;36(2):231-44.
2009: Julie M Claycomb; Pedro J Batista; Ka Ming Pang; Weifeng Gu; Jessica J Vasale; Josien C van Wolfswinkel; Daniel A Chaves; Masaki Shirayama; Shohei Mitani; René F Ketting; Darryl Conte; Craig C Mello
The Argonaute CSR-1 and its 22G-RNA cofactors are required for holocentric chromosome segregation.
Cell 2009;139(1):123-34.
2009: Craig C Mello; John V Walsh
The time to demand funding.
Science (New York, N.Y.) 2009;323(5911):208.
2008: Pedro J Batista; J Graham Ruby; Julie M Claycomb; Rosaria Chiang; Noah Fahlgren; Kristin D Kasschau; Daniel A Chaves; Weifeng Gu; Jessica J Vasale; Shenghua Duan; Darryl Conte; Shujun Luo; Gary P Schroth; James C Carrington; David P Bartel; Craig C Mello
PRG-1 and 21U-RNAs interact to form the piRNA complex required for fertility in C. elegans.
Molecular cell 2008;31(1):67-78.
2007: Craig C Mello
Return to the RNAi world: rethinking gene expression and evolution.
Cell death and differentiation 2007;14(12):2013-20.
2007: Craig C Mello
A conversation with Craig C Mello on the discovery of RNAi.
Cell death and differentiation 2007;14(12):1981-4.
2007: Craig C Mello
Return to the RNAi world: rethinking gene expression and evolution (Nobel Lecture).
Angewandte Chemie (International ed. in English) 2007;46(37):6985-94.
2006: Erbay Yigit; Pedro J Batista; Yanxia Bei; Ka Ming Pang; Chun-Chieh G Chen; Niraj H Tolia; Leemor Joshua-Tor; Shohei Mitani; Martin J Simard; Craig C Mello
Analysis of the C. elegans Argonaute family reveals that distinct Argonautes act sequentially during RNAi.
Cell 2006;127(4):747-57.
2006: Akira Hayakawa; Deborah Leonard; Stephanie Murphy; Susan Hayes; Martha Soto; Kevin E Fogarty; Clive Standley; Karl D Bellve; David G Lambright; Craig C Mello; Silvia Corvera
The WD40 and FYVE domain containing protein 2 defines a class of early endosomes necessary for endocytosis.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(32):11928-33.
2006: Thomas F Duchaine; James Wohlschlegel; Scott Kennedy; Yanxia Bei; Darryl Conte; Kaming Pang; Daniel R Brownell; Sandra Harding; Shohei Mitani; Gary Ruvkun; John R Yates; Craig C Mello
Functional proteomics reveals the biochemical niche of C. elegans DCR-1 in multiple small-RNA-mediated pathways.
Cell 2006;124(2):343-54.
2006: Masaki Shirayama; Martha C Soto; Takao Ishidate; Soyoung Kim; Kuniaki Nakamura; Yanxia Bei; Sander van den Heuvel; Craig C Mello
The Conserved Kinases CDK-1, GSK-3, KIN-19, and MBK-2 Promote OMA-1 Destruction to Regulate the Oocyte-to-Embryo Transition in C. elegans.
Current biology : CB 2006;16(1):47-55.
2005: Kuniaki Nakamura; Soyoung Kim; Takao Ishidate; Yanxia Bei; Kaming Pang; Masaki Shirayama; Chris Trzepacz; Daniel R Brownell; Craig C Mello
Wnt signaling drives WRM-1/beta-catenin asymmetries in early C. elegans embryos.
Genes & development 2005;19(15):1749-54.
2005: Duo Wang; Scott Kennedy; Darryl Conte; John Kim; Harrison W Gabel; Ravi S Kamath; Craig C Mello; Gary Ruvkun
Somatic misexpression of germline P granules and enhanced RNA interference in retinoblastoma pathway mutants.
Nature 2005;436(7050):593-7.
2005: Chun-Chieh G Chen; Martin J Simard; Hiroaki Tabara; Daniel R Brownell; Jennifer A McCollough; Craig C Mello
A member of the polymerase beta nucleotidyltransferase superfamily is required for RNA interference in C. elegans.
Current biology : CB 2005;15(4):378-83.
2005: Bastiaan B J Tops; Hiroaki Tabara; Titia Sijen; Femke Simmer; Craig C Mello; Ronald H Plasterk; René F Ketting
RDE-2 interacts with MUT-7 to mediate RNA interference in Caenorhabditis elegans.
Nucleic acids research 2005;33(1):347-55.
2004: Craig C Mello; Michael P Czech
Micromanaging insulin secretion.
Nature medicine 2004;10(12):1297-8.
2004: Anastasia P Grigorenko; Yuri K Moliaka; Martha C Soto; Craig C Mello; Evgeny I Rogaev
The Caenorhabditis elegans IMPAS gene, imp-2, is essential for development and is functionally distinct from related presenilins.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(41):14955-60.
2004: Craig C Mello; Darryl Conte
Revealing the world of RNA interference.
Nature 2004;431(7006):338-42.
2004: György Hutvágner; Martin J Simard; Craig C Mello; Phillip D Zamore
Sequence-specific inhibition of small RNA function.
PLoS biology 2004;2(4):E98.
2004: Ka Ming Pang; Takao Ishidate; Kuniaki Nakamura; Masaki Shirayama; Chris Trzepacz; Charlotte M Schubert; James R Priess; Craig C Mello
The minibrain kinase homolog, mbk-2, is required for spindle positioning and asymmetric cell division in early C. elegans embryos.
Developmental biology 2004;265(1):127-39.
2003: Tae Ho Shin; Craig C Mello
Chromatin regulation during C. elegans germline development.
Current opinion in genetics & development 2003;13(5):455-62.
2003: Kavitha Venkatesan; Heather R McManus; Craig C Mello; Temple F Smith; Ulla Hansen
Functional conservation between members of an ancient duplicated transcription factor family, LSF/Grainyhead.
Nucleic acids research 2003;31(15):4304-16.
2003: Lisa D. Timmons; Hiroaki Tabara; Craig C Mello; Andrew Fire
Inducible systemic RNA silencing in Caenorhabditis elegans.
Molecular biology of the cell 2003;14(7):2972-83.
2003: Darryl Conte; Craig C Mello
RNA interference in Caenorhabditis elegans.
Current protocols in molecular biology / edited by Frederick M. Ausubel ... [et al.] 2003;Chapter 26():Unit 26.3.
2002: Yingdee Unhavaithaya; Tae Ho Shin; Nicholas Miliaras; Jungsoon Lee; Tomoko Oyama; Craig C Mello
MEP-1 and a homolog of the NURD complex component Mi-2 act together to maintain germline-soma distinctions in C. elegans.
Cell 2002;111(7):991-1002.
2002: Yanxia Bei; Jennifer Hogan; Laura A Berkowitz; Martha Soto; Christian E Rocheleau; Ka Ming Pang; John Collins; Craig C Mello
SRC-1 and Wnt signaling act together to specify endoderm and to control cleavage orientation in early C. elegans embryos.
Developmental cell 2002;3(1):113-25.
2002: Hiroaki Tabara; Erbay Yigit; Haruhiko Siomi; Craig C Mello
The dsRNA binding protein RDE-4 interacts with RDE-1, DCR-1, and a DExH-box helicase to direct RNAi in C. elegans.
Cell 2002;109(7):861-71.
2002: Martha C Soto; Hiroshi Qadota; Katsuhisa Kasuya; Makiko Inoue; Daisuke Tsuboi; Craig C Mello; Kozo Kaibuchi
The GEX-2 and GEX-3 proteins are required for tissue morphogenesis and cell migrations in C. elegans.
Genes & development 2002;16(5):620-32.
2002: Alla Grishok; Craig C Mello
RNAi (Nematodes: Caenorhabditis elegans).
Advances in genetics 2002;46():339-60.
2002: Martin Victor; Yanxia Bei; Frédérique Gay; Dominica Calvo; Craig C Mello; Yang Shi
HAT activity is essential for CBP-1-dependent transcription and differentiation in Caenorhabditis elegans.
EMBO reports 2002;3(1):50-5.
2001: Alla Grishok; Amy E Pasquinelli; Darryl Conte; N Li; Susan Parrish; I Ha; David Baillie; Andrew Fire; Gary Ruvkun; Craig C Mello
Genes and mechanisms related to RNA interference regulate expression of the small temporal RNAs that control C. elegans developmental timing.
Cell 2001;106(1):23-34.
2000: Susan Parrish; Jamie Fleenor; S Xu; Craig C Mello; Andrew Fire
Functional anatomy of a dsRNA trigger: differential requirement for the two trigger strands in RNA interference.
Molecular cell 2000;6(5):1077-87.
2000: Alla Grishok; Hiroaki Tabara; Craig C Mello
Genetic requirements for inheritance of RNAi in C. elegans.
Science (New York, N.Y.) 2000;287(5462):2494-7.
1999: Hiroaki Tabara; M Sarkissian; WG Kelly; Jamie Fleenor; Alla Grishok; Lisa D. Timmons; Andrew Fire; Craig C Mello
The rde-1 gene, RNA interference, and transposon silencing in C. elegans.
Cell 1999;99(2):123-32.
1999: Tae Ho Shin; Jun Yasuda; Christian E Rocheleau; Rueyling Lin; Martha Soto; Yanxia Bei; Roger J Davis; Craig C Mello
MOM-4, a MAP kinase kinase kinase-related protein, activates WRM-1/LIT-1 kinase to transduce anterior/posterior polarity signals in C. elegans.
Molecular cell 1999;4(2):275-80.
1999: Christian E Rocheleau; Jun Yasuda; Tae Ho Shin; Rueyling Lin; H Sawa; H Okano; James R Priess; Roger J Davis; Craig C Mello
WRM-1 activates the LIT-1 protein kinase to transduce anterior/posterior polarity signals in C. elegans.
Cell 1999;97(6):717-26.
1999: C Batchelder; MA Dunn; Bob K Choy; Y Suh; C Cassie; Eun Yong Shim; T H Shin; Craig C Mello; Geraldine Seydoux; T Keith Blackwell
Transcriptional repression by the Caenorhabditis elegans germ-line protein PIE-1.
Genes & development 1999;13(2):202-12.
1999: Hiroaki Tabara; Russell J Hill; Craig C Mello; James R Priess; Y Kohara
pos-1 encodes a cytoplasmic zinc-finger protein essential for germline specification in C. elegans.
Development (Cambridge, England) 1999;126(1):1-11.
1998: Hiroaki Tabara; Alla Grishok; Craig C Mello
RNAi in C. elegans: soaking in the genome sequence.
Science (New York, N.Y.) 1998;282(5388):430-1.
1998: Yang Shi; Craig C Mello
A CBP/p300 homolog specifies multiple differentiation pathways in Caenorhabditis elegans.
Genes & development 1998;12(7):943-55.
1998: Andrew Fire; S Xu; MK Montgomery; Stephen A Kostas; Samuel E Driver; Craig C Mello
Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans.
Nature 1998;391(6669):806-11.
1997: Christian E Rocheleau; W D Downs; Rueyling Lin; C Wittmann; Yanxia Bei; Yoon-Hee Cha; M Ali; James R Priess; Craig C Mello
Wnt signaling and an APC-related gene specify endoderm in early C. elegans embryos.
Cell 1997;90(4):707-16.
1996: Bruce W Draper; Craig C Mello; B Bowerman; Jeff Hardin; James R Priess
MEX-3 is a KH domain protein that regulates blastomere identity in early C. elegans embryos.
Cell 1996;87(2):205-16.
1996: Jennifer L Watts; B Etemad-Moghadam; S Guo; Lynn Boyd; Bruce W Draper; Craig C Mello; James R Priess; Kenneth J Kemphues
par-6, a gene involved in the establishment of asymmetry in early C. elegans embryos, mediates the asymmetric localization of PAR-3.
Development (Cambridge, England) 1996;122(10):3133-40.
1996: Geraldine Seydoux; Craig C Mello; J Pettitt; William B Wood; James R Priess; Andrew Fire
Repression of gene expression in the embryonic germ lineage of C. elegans.
Nature 1996;382(6593):713-6.
1996: Craig C Mello; C Schubert; Bruce W Draper; W Zhang; R Lobel; James R Priess
The PIE-1 protein and germline specification in C. elegans embryos.
Nature 1996;382(6593):710-2.
1996: K M Mickey; Craig C Mello; MK Montgomery; Andrew Fire; James R Priess
An inductive interaction in 4-cell stage C. elegans embryos involves APX-1 expression in the signalling cell.
Development (Cambridge, England) 1996;122(6):1791-8.
1995: Craig C Mello; Andrew Fire
DNA transformation.
Methods in cell biology 1995;48():451-82.
1994: D J Levitan; Lynn Boyd; Craig C Mello; Kenneth J Kemphues; D T Stinchcomb
par-2, a gene required for blastomere asymmetry in Caenorhabditis elegans, encodes zinc-finger and ATP-binding motifs.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(13):6108-12.
1994: Craig C Mello; Bruce W Draper; James R Priess
The maternal genes apx-1 and glp-1 and establishment of dorsal-ventral polarity in the early C. elegans embryo.
Cell 1994;77(1):95-106.
1993: M H Sibley; Jeremy James Johnson; Craig C Mello; James M Kramer
Genetic identification, sequence, and alternative splicing of the Caenorhabditis elegans alpha 2(IV) collagen gene.
The Journal of cell biology 1993;123(1):255-64.
1993: B Bowerman; Bruce W Draper; Craig C Mello; James R Priess
The maternal gene skn-1 encodes a protein that is distributed unequally in early C. elegans embryos.
Cell 1993;74(3):443-52.
1992: Craig C Mello; Bruce W Draper; M Krause; H Weintraub; James R Priess
The pie-1 and mex-1 genes and maternal control of blastomere identity in early C. elegans embryos.
Cell 1992;70(1):163-76.
1991: Craig C Mello; James M Kramer; D Stinchcomb; Victor Ambros
Efficient gene transfer in C.elegans: extrachromosomal maintenance and integration of transforming sequences.
The EMBO journal 1991;10(12):3959-70.
1985: D T Stinchcomb; Craig C Mello; D Hirsh
Caenorhabditis elegans DNA that directs segregation in yeast cells.
Proceedings of the National Academy of Sciences of the United States of America 1985;82(12):4167-71.