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Craig Mello
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Research Profile (preview)
Living Beings
Chemicals & Drugs
Concepts & Ideas
Genes & Molecular Sequences
Phenomena
Anatomy
Physiology
Procedures
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Network (preview)
12
Priess, James
8
Tabara, Hiroaki
8
Fire, Andrew
7
Conte, Darryl
7
Bei, Yanxia
5
Grishok, Alla
5
Shirayama, Masaki
4
Shin, Tae Ho
4
Rocheleau, Christian
4
Pang, Ka Ming
3
Nakamura, Kuniaki
3
Ruvkun, Gary
3
Ishidate, Takao
3
Lin, Rueyling
3
Brownell, Daniel
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Geonetwork of Craig Mello (preview)
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All Publications
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2009: Claycomb Julie M; Batista Pedro J; Pang Ka Ming; Gu Weifeng; Vasale Jessica J; van Wolfswinkel Josien C; Chaves Daniel A; Shirayama Masaki; Mitani Shohei; Ketting René F; Conte Darryl; Mello Craig C
The Argonaute CSR-1 and its 22G-RNA cofactors are required for holocentric chromosome segregation.
Cell 2009;139(1):123-34.
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2009: Gu Weifeng; Shirayama Masaki; Conte Darryl; Vasale Jessica; Batista Pedro J; Claycomb Julie M; Moresco James J; Youngman Elaine M; Keys Jennifer; Stoltz Matthew J; Chen Chun-Chieh G; Chaves Daniel A; Duan Shenghua; Kasschau Kristin D; Fahlgren Noah; Yates John R; Mitani Shohei; Carrington James C; Mello Craig C
Distinct argonaute-mediated 22G-RNA pathways direct genome surveillance in the C. elegans germline.
Molecular cell 2009;36(2):231-44.
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2009: Mello Craig C; Walsh John V
The time to demand funding.
Science (New York, N.Y.) 2009;323(5911):208.
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2008: Batista Pedro J; Ruby J Graham; Claycomb Julie M; Chiang Rosaria; Fahlgren Noah; Kasschau Kristin D; Chaves Daniel A; Gu Weifeng; Vasale Jessica J; Duan Shenghua; Conte Darryl; Luo Shujun; Schroth Gary P; Carrington James C; Bartel David P; Mello Craig C
PRG-1 and 21U-RNAs interact to form the piRNA complex required for fertility in C. elegans.
Molecular cell 2008;31(1):67-78.
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2007: Mello Craig C
Return to the RNAi world: rethinking gene expression and evolution.
Cell death and differentiation 2007;14(12):2013-20.
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2007: Mello Craig C
A conversation with Craig C Mello on the discovery of RNAi.
Cell death and differentiation 2007;14(12):1981-4.
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2007: Mello Craig C
Return to the RNAi world: rethinking gene expression and evolution (Nobel Lecture).
Angewandte Chemie (International ed. in English) 2007;46(37):6985-94.
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2006: Yigit Erbay; Batista Pedro J; Bei Yanxia; Pang Ka Ming; Chen Chun-Chieh G; Tolia Niraj H; Joshua-Tor Leemor; Mitani Shohei; Simard Martin J; Mello Craig C
Analysis of the C. elegans Argonaute family reveals that distinct Argonautes act sequentially during RNAi.
Cell 2006;127(4):747-57.
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2006: Hayakawa Akira; Leonard Deborah; Murphy Stephanie; Hayes Susan; Soto Martha; Fogarty Kevin; Standley Clive; Bellve Karl; Lambright David; Mello Craig; Corvera Silvia
The WD40 and FYVE domain containing protein 2 defines a class of early endosomes necessary for endocytosis.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(32):11928-33.
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2006: Duchaine Thomas F; Wohlschlegel James A; Kennedy Scott; Bei Yanxia; Conte Darryl; Pang Kaming; Brownell Daniel R; Harding Sandra; Mitani Shohei; Ruvkun Gary; Yates John R; Mello Craig C
Functional proteomics reveals the biochemical niche of C. elegans DCR-1 in multiple small-RNA-mediated pathways.
Cell 2006;124(2):343-54.
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2006: Shirayama Masaki; Soto Martha C; Ishidate Takao; Kim Soyoung; Nakamura Kuniaki; Bei Yanxia; van den Heuvel Sander; Mello Craig C
The Conserved Kinases CDK-1, GSK-3, KIN-19, and MBK-2 Promote OMA-1 Destruction to Regulate the Oocyte-to-Embryo Transition in C. elegans.
Current biology : CB 2006;16(1):47-55.
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2005: Nakamura Kuniaki; Kim Soyoung; Ishidate Takao; Bei Yanxia; Pang Kaming; Shirayama Masaki; Trzepacz Chris; Brownell Daniel R; Mello Craig C
Wnt signaling drives WRM-1/beta-catenin asymmetries in early C. elegans embryos.
Genes & development 2005;19(15):1749-54.
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2005: Wang Duo; Kennedy Scott; Conte Darryl; Kim John K; Gabel Harrison W; Kamath Ravi S; Mello Craig C; Ruvkun Gary
Somatic misexpression of germline P granules and enhanced RNA interference in retinoblastoma pathway mutants.
Nature 2005;436(7050):593-7.
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2005: Chen Chun-Chieh G; Simard Martin J; Tabara Hiroaki; Brownell Daniel R; McCollough Jennifer A; Mello Craig C
A member of the polymerase beta nucleotidyltransferase superfamily is required for RNA interference in C. elegans.
Current biology : CB 2005;15(4):378-83.
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2005: Tops Bastiaan B J; Tabara Hiroaki; Sijen Titia; Simmer Femke; Mello Craig C; Plasterk Ronald H A; Ketting René F
RDE-2 interacts with MUT-7 to mediate RNA interference in Caenorhabditis elegans.
Nucleic acids research 2005;33(1):347-55.
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2004: Mello Craig C; Czech Michael P
Micromanaging insulin secretion.
Nature medicine 2004;10(12):1297-8.
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2004: Grigorenko Anastasia P; Moliaka Yuri K; Soto Martha C; Mello Craig C; Rogaev Evgeny I
The Caenorhabditis elegans IMPAS gene, imp-2, is essential for development and is functionally distinct from related presenilins.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(41):14955-60.
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2004: Mello Craig C; Conte Darryl
Revealing the world of RNA interference.
Nature 2004;431(7006):338-42.
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2004: Hutvágner György; Simard Martin J; Mello Craig C; Zamore Phillip D
Sequence-specific inhibition of small RNA function.
PLoS biology 2004;2(4):E98.
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2004: Pang Ka Ming; Ishidate Takao; Nakamura Kuniaki; Shirayama Masaki; Trzepacz Chris; Schubert Charlotte M; Priess James R; Mello Craig C
The minibrain kinase homolog, mbk-2, is required for spindle positioning and asymmetric cell division in early C. elegans embryos.
Developmental biology 2004;265(1):127-39.
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2003: Shin Tae Ho; Mello Craig C
Chromatin regulation during C. elegans germline development.
Current opinion in genetics & development 2003;13(5):455-62.
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2003: Venkatesan Kavitha; McManus Heather R; Mello Craig C; Smith Temple F; Hansen Ulla
Functional conservation between members of an ancient duplicated transcription factor family, LSF/Grainyhead.
Nucleic acids research 2003;31(15):4304-16.
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2003: Timmons Lisa; Tabara Hiroaki; Mello Craig C; Fire Andrew Z
Inducible systemic RNA silencing in Caenorhabditis elegans.
Molecular biology of the cell 2003;14(7):2972-83.
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2003: Conte Darryl; Mello Craig C
RNA interference in Caenorhabditis elegans.
Current protocols in molecular biology / edited by Frederick M. Ausubel ... [et al.] 2003;Chapter 26():Unit 26.3.
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2002: Unhavaithaya Yingdee; Shin Tae Ho; Miliaras Nicholas; Lee Jungsoon; Oyama Tomoko; Mello Craig C
MEP-1 and a homolog of the NURD complex component Mi-2 act together to maintain germline-soma distinctions in C. elegans.
Cell 2002;111(7):991-1002.
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2002: Bei Yanxia; Hogan Jennifer; Berkowitz Laura A; Soto Martha; Rocheleau Christian E; Pang Ka Ming; Collins John; Mello Craig C
SRC-1 and Wnt signaling act together to specify endoderm and to control cleavage orientation in early C. elegans embryos.
Developmental cell 2002;3(1):113-25.
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2002: Tabara Hiroaki; Yigit Erbay; Siomi Haruhiko; Mello Craig C
The dsRNA binding protein RDE-4 interacts with RDE-1, DCR-1, and a DExH-box helicase to direct RNAi in C. elegans.
Cell 2002;109(7):861-71.
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2002: Soto Martha C; Qadota Hiroshi; Kasuya Katsuhisa; Inoue Makiko; Tsuboi Daisuke; Mello Craig C; Kaibuchi Kozo
The GEX-2 and GEX-3 proteins are required for tissue morphogenesis and cell migrations in C. elegans.
Genes & development 2002;16(5):620-32.
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2002: Victor Martin; Bei Yanxia; Gay Frederique; Calvo Dominica; Mello Craig; Shi Yang
HAT activity is essential for CBP-1-dependent transcription and differentiation in Caenorhabditis elegans.
EMBO reports 2002;3(1):50-5.
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2002: Grishok Alla; Mello Craig C
RNAi (Nematodes: Caenorhabditis elegans).
Advances in genetics 2002;46():339-60.
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2001: Grishok A; Pasquinelli A E; Conte D; Li N; Parrish S; Ha I; Baillie D L; Fire A; Ruvkun G; Mello C C
Genes and mechanisms related to RNA interference regulate expression of the small temporal RNAs that control C. elegans developmental timing.
Cell 2001;106(1):23-34.
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2000: Parrish S; Fleenor J; Xu S; Mello C; Fire A
Functional anatomy of a dsRNA trigger: differential requirement for the two trigger strands in RNA interference.
Molecular cell 2000;6(5):1077-87.
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2000: Grishok A; Tabara H; Mello C C
Genetic requirements for inheritance of RNAi in C. elegans.
Science (New York, N.Y.) 2000;287(5462):2494-7.
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1999: Tabara H; Sarkissian M; Kelly W G; Fleenor J; Grishok A; Timmons L; Fire A; Mello C C
The rde-1 gene, RNA interference, and transposon silencing in C. elegans.
Cell 1999;99(2):123-32.
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1999: Shin T H; Yasuda J; Rocheleau C E; Lin R; Soto M; Bei Y; Davis R J; Mello C C
MOM-4, a MAP kinase kinase kinase-related protein, activates WRM-1/LIT-1 kinase to transduce anterior/posterior polarity signals in C. elegans.
Molecular cell 1999;4(2):275-80.
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1999: Rocheleau C E; Yasuda J; Shin T H; Lin R; Sawa H; Okano H; Priess J R; Davis R J; Mello C C
WRM-1 activates the LIT-1 protein kinase to transduce anterior/posterior polarity signals in C. elegans.
Cell 1999;97(6):717-26.
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1999: Batchelder C; Dunn M A; Choy B; Suh Y; Cassie C; Shim E Y; Shin T H; Mello C; Seydoux G; Blackwell T K
Transcriptional repression by the Caenorhabditis elegans germ-line protein PIE-1.
Genes & development 1999;13(2):202-12.
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1999: Tabara H; Hill R J; Mello C C; Priess J R; Kohara Y
pos-1 encodes a cytoplasmic zinc-finger protein essential for germline specification in C. elegans.
Development (Cambridge, England) 1999;126(1):1-11.
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1998: Tabara H; Grishok A; Mello C C
RNAi in C. elegans: soaking in the genome sequence.
Science (New York, N.Y.) 1998;282(5388):430-1.
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1998: Shi Y; Mello C
A CBP/p300 homolog specifies multiple differentiation pathways in Caenorhabditis elegans.
Genes & development 1998;12(7):943-55.
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1998: Fire A; Xu S; Montgomery M K; Kostas S A; Driver S E; Mello C C
Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans.
Nature 1998;391(6669):806-11.
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1997: Rocheleau C E; Downs W D; Lin R; Wittmann C; Bei Y; Cha Y H; Ali M; Priess J R; Mello C C
Wnt signaling and an APC-related gene specify endoderm in early C. elegans embryos.
Cell 1997;90(4):707-16.
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1996: Watts J L; Etemad-Moghadam B; Guo S; Boyd L; Draper B W; Mello C C; Priess J R; Kemphues K J
par-6, a gene involved in the establishment of asymmetry in early C. elegans embryos, mediates the asymmetric localization of PAR-3.
Development (Cambridge, England) 1996;122(10):3133-40.
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1996: Draper B W; Mello C C; Bowerman B; Hardin J; Priess J R
MEX-3 is a KH domain protein that regulates blastomere identity in early C. elegans embryos.
Cell 1996;87(2):205-16.
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1996: Seydoux G; Mello C C; Pettitt J; Wood W B; Priess J R; Fire A
Repression of gene expression in the embryonic germ lineage of C. elegans.
Nature 1996;382(6593):713-6.
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1996: Mello C C; Schubert C; Draper B; Zhang W; Lobel R; Priess J R
The PIE-1 protein and germline specification in C. elegans embryos.
Nature 1996;382(6593):710-2.
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1996: Mickey K M; Mello C C; Montgomery M K; Fire A; Priess J R
An inductive interaction in 4-cell stage C. elegans embryos involves APX-1 expression in the signalling cell.
Development (Cambridge, England) 1996;122(6):1791-8.
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1995: Mello C; Fire A
DNA transformation.
Methods in cell biology 1995;48():451-82.
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1994: Levitan D J; Boyd L; Mello C C; Kemphues K J; Stinchcomb D T
par-2, a gene required for blastomere asymmetry in Caenorhabditis elegans, encodes zinc-finger and ATP-binding motifs.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(13):6108-12.
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1994: Mello C C; Draper B W; Priess J R
The maternal genes apx-1 and glp-1 and establishment of dorsal-ventral polarity in the early C. elegans embryo.
Cell 1994;77(1):95-106.
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1993: Sibley M H; Johnson J J; Mello C C; Kramer J M
Genetic identification, sequence, and alternative splicing of the Caenorhabditis elegans alpha 2(IV) collagen gene.
The Journal of cell biology 1993;123(1):255-64.
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1993: Bowerman B; Draper B W; Mello C C; Priess J R
The maternal gene skn-1 encodes a protein that is distributed unequally in early C. elegans embryos.
Cell 1993;74(3):443-52.
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1992: Mello C C; Draper B W; Krause M; Weintraub H; Priess J R
The pie-1 and mex-1 genes and maternal control of blastomere identity in early C. elegans embryos.
Cell 1992;70(1):163-76.
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1991: Mello C C; Kramer J M; Stinchcomb D; Ambros V
Efficient gene transfer in C.elegans: extrachromosomal maintenance and integration of transforming sequences.
The EMBO journal 1991;10(12):3959-70.
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1985: Stinchcomb D T; Mello C; Hirsh D
Caenorhabditis elegans DNA that directs segregation in yeast cells.
Proceedings of the National Academy of Sciences of the United States of America 1985;82(12):4167-71.
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