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Synthia Mellon

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Seonok Lee; Synthia H Mellon; Stephanie A Redmond; Samuel J Tuck; S Y Christin Chong; Joseph M Corey; Zhang-Qi Feng; Michelle K Leach; Jonah R Chan
A culture system to study oligodendrocyte myelination processes using engineered nanofibers.
Marcus D Schonemann; Meng Kian Tee; Walter L Miller; Marcus O Muench; Synthia H Mellon
Expression of P450c17 in the human fetal nervous system.
Owen Wolkowitz; Heather M Burke; M Compagnone; Firdaus S Dhabhar; Elissa S Epel; Jue Lin; Synthia H Mellon; J Craig Nelson; V I Reus; R Rosser; Elizabeth H Blackburn
Resting leukocyte telomerase activity is elevated in major depression and predicts treatment response.

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2012: Seonok Lee; Synthia H Mellon; Stephanie A Redmond; Samuel J Tuck; S Y Christin Chong; Joseph M Corey; Zhang-Qi Feng; Michelle K Leach; Jonah R Chan
A culture system to study oligodendrocyte myelination processes using engineered nanofibers.
Nature methods 2012;9(9):917-22.
2012: Marcus D Schonemann; Meng Kian Tee; Walter L Miller; Marcus O Muench; Synthia H Mellon
Expression of P450c17 in the human fetal nervous system.
Endocrinology 2012;153(5):2494-505.
2012: Owen Wolkowitz; Heather M Burke; M Compagnone; Firdaus S Dhabhar; Elissa S Epel; Jue Lin; Synthia H Mellon; J Craig Nelson; V I Reus; R Rosser; Elizabeth H Blackburn
Resting leukocyte telomerase activity is elevated in major depression and predicts treatment response.
Molecular psychiatry 2012;17(2):164-72.
2011: Owen M Wolkowitz; Heather M Burke; Elissa S Epel; George K Lerner; J Craig Nelson; Victor I Reus; Rebecca Rosser; Wendy Shelly; Jessica Wolf; Synthia H Mellon
Serum BDNF levels before treatment predict SSRI response in depression.
Progress in neuro-psychopharmacology & biological psychiatry 2011;35(7):1623-30.
2011: Owen Wolkowitz; Victor I Reus; Synthia H Mellon
Of sound mind and body: depression, disease, and accelerated aging.
Dialogues in clinical neuroscience 2011;13(1):25-39.
2011: Owen Wolkowitz; Synthia H Mellon; Elissa S Epel; Jue Lin; Firdaus S Dhabhar; Yali Su; Victor I Reus; Rebecca Rosser; Heather M Burke; Eve Kupferman; Mariana Compagnone; J Craig Nelson; Elizabeth H Blackburn
Leukocyte telomere length in major depression: correlations with chronicity, inflammation and oxidative stress--preliminary findings.
PloS one 2011;6(3):e17837.
2010: William Berger; Akhil Mehra; Maryanne Lenoci; Thomas J Metzler; Christian Otte; Gary Tarasovsky; Synthia H Mellon; Owen Wolkowitz; Charles Marmar; Thomas Neylan
Serum brain-derived neurotrophic factor predicts responses to escitalopram in chronic posttraumatic stress disorder.
Progress in neuro-psychopharmacology & biological psychiatry 2010;34(7):1279-84.
2010: Owen Wolkowitz; Elissa S Epel; Victor I Reus; Synthia H Mellon
Depression gets old fast: do stress and depression accelerate cell aging?
Depression and anxiety 2010;27(4):327-38.
2010: Jue Lin; Elissa S Epel; Joshua Cheon; Candyce H Kroenke; Elizabeth Sinclair; Marty Bigos; Owen Wolkowitz; Synthia H Mellon; Elizabeth Blackburn
Analyses and comparisons of telomerase activity and telomere length in human T and B cells: insights for epidemiology of telomere maintenance.
Journal of immunological methods 2010;352(1-2):71-80.
2010: Lili Zhang; Brigitte E Blackman; Marcus D Schonemann; Tatjana Zogovic-Kapsalis; Xiaoyu Pan; Mary Tagliaferri; Heather A Harris; Isaac Cohen; Renee A Reijo Pera; Synthia H Mellon; Richard I Weiner; Dale C Leitman
Estrogen receptor beta-selective agonists stimulate calcium oscillations in human and mouse embryonic stem cell-derived neurons.
PloS one 2010;5(7):e11791.
2009: Sophia Vinogradov; Melissa Fisher; Christine Holland; Wendy Shelly; Owen Wolkowitz; Synthia H Mellon
Is serum brain-derived neurotrophic factor a biomarker for cognitive enhancement in schizophrenia?
Biological psychiatry 2009;66(6):549-53.
2009: Firdaus S Dhabhar; Heather M Burke; Elissa S Epel; Synthia H Mellon; Rebecca Rosser; Victor I Reus; Owen Wolkowitz
Low serum IL-10 concentrations and loss of regulatory association between IL-6 and IL-10 in adults with major depression.
Journal of psychiatric research 2009;43(11):962-9.
2009: Yimin Shi; Marcus D Schonemann; Synthia H Mellon
Regulation of P450c17 expression in the early embryo depends on GATA factors.
Endocrinology 2009;150(2):946-56.
2009: Nicole Maninger; Owen Wolkowitz; Victor I Reus; Elissa S Epel; Synthia H Mellon
Neurobiological and neuropsychiatric effects of dehydroepiandrosterone (DHEA) and DHEA sulfate (DHEAS).
Frontiers in neuroendocrinology 2009;30(1):65-91.
2008: Synthia H Mellon; Wenhui Gong; Marcus D Schonemann
Endogenous and synthetic neurosteroids in treatment of Niemann-Pick Type C disease.
Brain research reviews 2008;57(2):410-20.
2008: Owen Wolkowitz; Elissa S Epel; Synthia H Mellon
When blue turns to grey: do stress and depression accelerate cell aging?
The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry 2008;9(1):2-5.
2007: Synthia H Mellon
Neurosteroid regulation of central nervous system development.
Pharmacology & therapeutics 2007;116(1):107-24.
2007: Synthia H Mellon; Susanna R Bair; Christophe Depoix; Jean-Louis Vigne; Norman B Hecht; Paul B Brake
Translin coactivates steroidogenic factor-1-stimulated transcription.
Molecular endocrinology (Baltimore, Md.) 2007;21(1):89-105.
2006: S Joshua Langmade; Sarah E Gale; Andrey Frolov; Ikuko Mohri; Kinuko Suzuki; Synthia H Mellon; Steven U Walkley; Douglas F Covey; Jean E Schaffer; Daniel S Ory
Pregnane X receptor (PXR) activation: a mechanism for neuroprotection in a mouse model of Niemann-Pick C disease.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(37):13807-12.
2005: Paul B Brake; Susanna R Bair; Synthia H Mellon
DNA sequence-dependent regulation of SF-1-mediated transcription.
DNA and cell biology 2005;24(3):148-60.
2004: Synthia H Mellon; Wenhui Gong; Lisa D Griffin
Niemann pick type C disease as a model for defects in neurosteroidogenesis.
Endocrine research 2004;30(4):727-35.
2004: Lisa D Griffin; Wenhui Gong; Lucie Verot; Synthia H Mellon
Niemann-Pick type C disease involves disrupted neurosteroidogenesis and responds to allopregnanolone.
Nature medicine 2004;10(7):704-11.
2004: Susanna R Bair; Synthia H Mellon
Deletion of the mouse P450c17 gene causes early embryonic lethality.
Molecular and cellular biology 2004;24(12):5383-90.
2004: Paul A Komesaroff; Mark A Bach; Ann Danoff; Melvin M Grumbach; Selna Kaplan; Joan M Lakoski; Dale C Leitman; Synthia H Mellon; Louis E Underwood; Sarah Leupen
The Endocrine Society Ethics Advisory Committee: ethical aspects of conflicts of interests, October 2003.
Endocrinology 2004;145(6):3032-41.
2004: Cheol Yi Hong; Jin Hee Park; Ryun Sup Ahn; Suhn-Young Im; Hueng-Sik Choi; Jaemog Soh; Synthia H Mellon; Keesook Lee
Molecular mechanism of suppression of testicular steroidogenesis by proinflammatory cytokine tumor necrosis factor alpha.
Molecular and cellular biology 2004;24(7):2593-604.
2004: Fabian Hammer; Nathalie A Compagnone; Jean-Louis Vigne; Susanna R Bair; Synthia H Mellon
Transcriptional regulation of P450scc gene expression in the embryonic rodent nervous system.
Endocrinology 2004;145(2):901-12.
2003: Amit V Pandey; Synthia H Mellon; Walter L Miller
Protein phosphatase 2A and phosphoprotein SET regulate androgen production by P450c17.
The Journal of biological chemistry 2003;278(5):2837-44.
2002: Synthia H Mellon; Lisa D Griffin
Synthesis, regulation, and function of neurosteroids.
Endocrine research 2002;28(4):463.
2002: Martin Y H Zhang; Xuemei Wang; Jonathan T Wang; Nathalie A Compagnone; Synthia H Mellon; Jean L Olson; Harriet S Tenenhouse; Walter L Miller; Anthony A Portale
Dietary phosphorus transcriptionally regulates 25-hydroxyvitamin D-1alpha-hydroxylase gene expression in the proximal renal tubule.
Endocrinology 2002;143(2):587-95.
2002: Synthia H Mellon; Lisa D Griffin
Neurosteroids: biochemistry and clinical significance.
Trends in endocrinology and metabolism: TEM 2002;13(1):35-43.
2001: Synthia H Mellon; Lisa D Griffin; Nathalie A Compagnone
Biosynthesis and action of neurosteroids.
Brain research. Brain research reviews 2001;37(1-3):3-12.
2001: Lisa D Griffin; Synthia H Mellon
Biosynthesis of the neurosteroid 3 alpha-hydroxy-4-pregnen-20-one (3 alpha hp), a specific inhibitor of FSH release.
Endocrinology 2001;142(11):4617-22.
2001: P Zhang; Nathalie A Compagnone; C Fiore; Jean-Louis Vigne; PA Culp; Thomas J Musci; Synthia H Mellon
Developmental gonadal expression of the transcription factor SET and its target gene, P450c17 (17alpha-hydroxylase/c17,20 lyase).
DNA and cell biology 2001;20(10):613-24.
2001: E Fujii; Synthia H Mellon
Regulation of uterine gamma-aminobutyric acid(A) receptor subunit expression throughout pregnancy.
Endocrinology 2001;142(5):1770-7.
2001: Lisa D Griffin; S C Conrad; Synthia H Mellon
Current perspectives on the role of neurosteroids in PMS and depression.
International review of neurobiology 2001;46():479-92.
2001: Synthia H Mellon; H Vaudry
Biosynthesis of neurosteroids and regulation of their synthesis.
International review of neurobiology 2001;46():33-78.
2001: Jean-Pierre Chanoine; Nathalie A Compagnone; Alfred C K Wong; Synthia H Mellon
Modulation of steroidogenesis by selenium in a novel adrenal cell line developed using targeted tumorigenesis.
BioFactors (Oxford, England) 2001;14(1-4):229-38.
2000: Saleh Adi; Z Q Cheng; P L Zhang; Nan-Yan Wu; Synthia H Mellon; Stephen M Rosenthal
Opposing early inhibitory and late stimulatory effects of insulin-like growth factor-I on myogenin gene transcription.
Journal of cellular biochemistry 2000;78(4):617-26.
2000: Nathalie A Compagnone; P Zhang; Jean-Louis Vigne; Synthia H Mellon
Novel role for the nuclear phosphoprotein SET in transcriptional activation of P450c17 and initiation of neurosteroidogenesis.
Molecular endocrinology (Baltimore, Md.) 2000;14(6):875-88.
2000: Holly A Ingraham; Y Hirokawa; Lori M Roberts; Synthia H Mellon; EA McGee; Mark W Nachtigal; Jenny A Visser
Autocrine and paracrine Müllerian inhibiting substance hormone signaling in reproduction.
Recent progress in hormone research 2000;55():53-67; discussion 67-8.
2000: Nathalie A Compagnone; Synthia H Mellon
Neurosteroids: biosynthesis and function of these novel neuromodulators.
Frontiers in neuroendocrinology 2000;21(1):1-56.
1999: L D Griffin; Synthia H Mellon
Selective serotonin reuptake inhibitors directly alter activity of neurosteroidogenic enzymes.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(23):13512-7.
1999: P Zhang; F Hammer; Susanna R Bair; J Wang; W H Reeves; Synthia H Mellon
Ku autoimmune antigen is involved in placental regulation of rat P450c17 gene transcription.
DNA and cell biology 1999;18(3):197-208.
1998: Synthia H Mellon; Nathalie A Compagnone; P Zhang
Orphan receptors, proto-oncogenes and other nuclear factors regulate P450C17 gene transcription.
Endocrine research 1998;24(3-4):505-13.
1998: Synthia H Mellon; Susanna R Bair
25-Hydroxycholesterol is not a ligand for the orphan nuclear receptor steroidogenic factor-1 (SF-1).
Endocrinology 1998;139(6):3026-9.
1998: Nathalie A Compagnone; Synthia H Mellon
Dehydroepiandrosterone: a potential signalling molecule for neocortical organization during development.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(8):4678-83.
1998: P Zhang; Jean-Louis Vigne; Synthia H Mellon
Polyribonucleotide phosphorylase is a double-stranded DNA-binding protein.
DNA and cell biology 1998;17(2):169-75.
1997: Nathalie A Compagnone; Eduardo Salido; Lawrence J Shapiro; Synthia H Mellon
Expression of steroid sulfatase during embryogenesis.
Endocrinology 1997;138(11):4768-73.
1997: P Zhang; Synthia H Mellon
Multiple orphan nuclear receptors converge to regulate rat P450c17 gene transcription: novel mechanisms for orphan nuclear receptor action.
Molecular endocrinology (Baltimore, Md.) 1997;11(7):891-904.
1997: Nathalie A Compagnone; Susanna R Bair; Synthia H Mellon
Characterization of adrenocortical cell lines produced by genetically targeted tumorigenesis in transgenic mice.
Steroids 1997;62(2):238-43.
1997: Synthia H Mellon; P Zhang
The testis and the adrenal are (transcriptionally) the same.
Steroids 1997;62(1):46-52.
1996: G F Scheumann; P Heitmann; O E Teebken; E Mössinger; Synthia H Mellon; Rudolf Pichlmayr
Enzymatic properties of transplanted glomerulosa cells.
World journal of surgery 1996;20(7):933-8; discussion 938-9.
1996: T Yamamoto; Belinda M Chapman; Donald Johnson; CR Givens; Synthia H Mellon; Michael J Soares
Cytochrome P450 17 alpha-hydroxylase gene expression in differentiating rat trophoblast cells.
The Journal of endocrinology 1996;150(1):161-8.
1996: P Zhang; X G Han; Synthia H Mellon; P F Hall
Expression of the gene for cytochrome P-450 17 alpha-hydroxylase/C17-20 lyase (CYP17) in porcine Leydig cells: identification of a DNA sequence that mediates cAMP response.
Biochimica et biophysica acta 1996;1307(1):73-82.
1996: P Zhang; Synthia H Mellon
The orphan nuclear receptor steroidogenic factor-1 regulates the cyclic adenosine 3',5'-monophosphate-mediated transcriptional activation of rat cytochrome P450c17 (17 alpha-hydroxylase/c17-20 lyase).
Molecular endocrinology (Baltimore, Md.) 1996;10(2):147-58.
1995: P Zhang; H Rodriguez; Synthia H Mellon
Transcriptional regulation of P450scc gene expression in neural and steroidogenic cells: implications for regulation of neurosteroidogenesis.
Molecular endocrinology (Baltimore, Md.) 1995;9(11):1571-82.
1995: Nathalie A Compagnone; Alessandro Bulfone; John L R Rubenstein; Synthia H Mellon
Steroidogenic enzyme P450c17 is expressed in the embryonic central nervous system.
Endocrinology 1995;136(11):5212-23.
1995: R G Allen; C Carey; J D Parker; M T Mortrud; Synthia H Mellon; Malcolm J Low
Targeted ablation of pituitary pre-proopiomelanocortin cells by herpes simplex virus-1 thymidine kinase differentially regulates mRNAs encoding the adrenocorticotropin receptor and aldosterone synthase in the mouse adrenal gland.
Molecular endocrinology (Baltimore, Md.) 1995;9(8):1005-16.
1995: C M Cover; J M Wang; E St Lezin; theodore kurtz; Synthia H Mellon
Molecular variants in the P450c11AS gene as determinants of aldosterone synthase activity in the Dahl rat model of hypertension.
The Journal of biological chemistry 1995;270(28):16555-60.
1995: Nathalie A Compagnone; Alessandro Bulfone; John L R Rubenstein; Synthia H Mellon
Expression of the steroidogenic enzyme P450scc in the central and peripheral nervous systems during rodent embryogenesis.
Endocrinology 1995;136(6):2689-96.
1995: B Djavidani; M Sander; R Kreutz; K Zeh; Michael Bader; Synthia H Mellon; P Vecsei; J Peters; Detlev Ganten
Chronic dexamethasone treatment suppresses hypertension development in the transgenic rat TGR(mREN2)27.
Journal of hypertension 1995;13(6):637-45.
1995: Carlos Fardella; H Rodriguez; D W Hum; Synthia H Mellon; Walter L Miller
Artificial mutations in P450c11AS (aldosterone synthase) can increase enzymatic activity: a model for low-renin hypertension?
The Journal of clinical endocrinology and metabolism 1995;80(3):1040-3.
1995: Synthia H Mellon; Susanna R Bair; H Monis
P450c11B3 mRNA, transcribed from a third P450c11 gene, is expressed in a tissue-specific, developmentally, and hormonally regulated fashion in the rodent adrenal and encodes a protein with both 11-hydroxylase and 18-hydroxylase activities.
The Journal of biological chemistry 1995;270(4):1643-9.
1995: Paul Saenger; Z Klonari; Stephen Matthew Black; Nathalie A Compagnone; Synthia H Mellon; Adiel Fleischer; C A Abrams; C H Shackelton; W L Miller
Prenatal diagnosis of congenital lipoid adrenal hyperplasia.
The Journal of clinical endocrinology and metabolism 1995;80(1):200-5.
1995: Synthia H Mellon; Nathalie A Compagnone; M Sander; C Cover; Detlev Ganten; B Djavidani
Rodent models for studying steroids and hypertension: from fetal development to cells in culture.
Steroids 1995;60(1):59-64.
1994: CR Givens; P Zhang; Susanna R Bair; Synthia H Mellon
Transcriptional regulation of rat cytochrome P450c17 expression in mouse Leydig MA-10 and adrenal Y-1 cells: identification of a single protein that mediates both basal and cAMP-induced activities.
DNA and cell biology 1994;13(11):1087-98.
1994: Synthia H Mellon
Neurosteroids: biochemistry, modes of action, and clinical relevance.
The Journal of clinical endocrinology and metabolism 1994;78(5):1003-8.
1994: M Sander; Detlev Ganten; Synthia H Mellon
Role of adrenal renin in the regulation of adrenal steroidogenesis by corticotropin.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(1):148-52.
1994: Synthia H Mellon; Walter L Miller; Susanna R Bair; C C Moore; Jean-Louis Vigne; Richard I Weiner
Steroidogenic adrenocortical cell lines produced by genetically targeted tumorigenesis in transgenic mice.
Molecular endocrinology (Baltimore, Md.) 1994;8(1):97-108.
1993: Synthia H Mellon; Christian Deschepper
Neurosteroid biosynthesis: genes for adrenal steroidogenic enzymes are expressed in the brain.
Brain research 1993;629(2):283-92.
1993: C C Moore; Synthia H Mellon; JT Murai; Pentti Siiteri; Walter L Miller
Structure and function of the hepatic form of 11 beta-hydroxysteroid dehydrogenase in the squirrel monkey, an animal model of glucocorticoid resistance.
Endocrinology 1993;133(1):368-75.
1993: James Bristow; Meng Kian Tee; Stephen E Gitelman; Synthia H Mellon; Walter L Miller
Tenascin-X: a novel extracellular matrix protein encoded by the human XB gene overlapping P450c21B.
The Journal of cell biology 1993;122(1):265-78.
1993: S Mesiano; Synthia H Mellon; Robert B Jaffe
Mitogenic action, regulation, and localization of insulin-like growth factors in the human fetal adrenal gland.
The Journal of clinical endocrinology and metabolism 1993;76(4):968-76.
1991: S Mesiano; Synthia H Mellon; D Gospodarowicz; A M Di Blasio; Robert B Jaffe
Basic fibroblast growth factor expression is regulated by corticotropin in the human fetal adrenal: a model for adrenal growth regulation.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(12):5428-32.
1991: M P Malee; Synthia H Mellon
Zone-specific regulation of two messenger RNAs for P450c11 in the adrenals of pregnant and nonpregnant rats.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(11):4731-5.
1991: Synthia H Mellon; J A Kushner; C Vaisse
Expression and regulation of adrenodoxin and P450scc mRNA in rodent tissues.
DNA and cell biology 1991;10(5):339-47.
1991: Synthia H Mellon; J E Shively; Walter L Miller
Human proopiomelanocortin-(79-96), a proposed androgen stimulatory hormone, does not affect steroidogenesis in cultured human fetal adrenal cells.
The Journal of clinical endocrinology and metabolism 1991;72(1):19-22.
1990: S T Brentano; J Picado-Leonard; Synthia H Mellon; C C Moore; Walter L Miller
Tissue-specific, cyclic adenosine 3',5'-monophosphate-induced, and phorbol ester-repressed transcription from the human P450c17 promoter in mouse cells.
Molecular endocrinology (Baltimore, Md.) 1990;4(12):1972-9.
1990: K A Elias; Richard I Weiner; Synthia H Mellon
Effect of extracellular matrix on prolactin secretion and mRNA accumulation in GH3 cells.
DNA and cell biology 1990;9(5):369-75.
1989: Synthia H Mellon; Walter L Miller
Extraadrenal steroid 21-hydroxylation is not mediated by P450c21.
The Journal of clinical investigation 1989;84(5):1497-502.
1989: Synthia H Mellon; C Vaisse
cAMP regulates P450scc gene expression by a cycloheximide-insensitive mechanism in cultured mouse Leydig MA-10 cells.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(20):7775-9.
1988: Synthia H Mellon; J D Baxter; A Gutierrez-Hartmann
Cell-specific expression of transfected brain identifier repetitive DNAs.
Nucleic acids research 1988;16(9):3963-76.
1987: A Lightman; Christian Deschepper; Synthia H Mellon; W F Ganong; Frederick Naftolin
In situ hybridization identifies renin mRNA in the rat corpus luteum.
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 1987;1(3):227-33.
1987: Brian L West; Daniel F Catanzaro; Synthia H Mellon; P A Cattini; J D Baxter; Timothy L Reudelhuber
Interaction of a tissue-specific factor with an essential rat growth hormone gene promoter element.
Molecular and cellular biology 1987;7(3):1193-7.
1986: Christian Deschepper; Synthia H Mellon; F Cumin; J D Baxter; W F Ganong
Analysis by immunocytochemistry and in situ hybridization of renin and its mRNA in kidney, testis, adrenal, and pituitary of the rat.
Proceedings of the National Academy of Sciences of the United States of America 1986;83(19):7552-6.
1985: Bon-Chu Chung; K J Matteson; J E Morin; Synthia H Mellon; Walter L Miller
An approach to the molecular biology of congenital adrenal hyperplasia.
Annals of the New York Academy of Sciences 1985;458():238-51.
1984: Michael Karin; Norman L Eberhardt; Synthia H Mellon; N Malich; R I Richards; E P Slater; A Barta; J A Martial; J D Baxter; G Cathala
Expression and hormonal regulation of the rat growth hormone gene in transfected mouse L cells.
DNA (Mary Ann Liebert, Inc.) 1984;3(2):147-55.
1982: S R Spindler; Synthia H Mellon; J D Baxter
Growth hormone gene transcription is regulated by thyroid and glucocorticoid hormones in cultured rat pituitary tumor cells.
The Journal of biological chemistry 1982;257(19):11627-32.