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Piero Melloni

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Sergio De Munari; Alberto Cerri; Mauro Gobbini; Nicoletta Almirante; Leonardo Banfi; Giulio Carzana; Patrizia Ferrari; Giuseppe Marazzi; Rosella Micheletti; Antonio Schiavone; Simona Sputore; Marco Torri; Maria Pia Zappavigna; Piero Melloni
Structure-based design and synthesis of novel potent Na+,K+ -ATPase inhibitors derived from a 5alpha,14alpha-androstane scaffold as positive inotropic compounds.
Patrizia Ferrari; Mara Ferrandi; Lucia Torielli; Paolo Barassi; Grazia Tripodi; Elena Minotti; Isabella Molinari; Piero Melloni; Giuseppe Bianchi
Antihypertensive compounds that modulate the Na-K pump.
Rosella Micheletti; Giovan Giuseppe Mattera; Marcella Rocchetti; Antonio Schiavone; M F Loi; Antonio Zaza; R J P Gagnol; Sergio De Munari; Piero Melloni; Paolo Carminati; Giuseppe Bianchi; Patrizia Ferrari
Pharmacological profile of the novel inotropic agent (E,Z)-3-((2-aminoethoxy)imino)androstane-6,17-dione hydrochloride (PST2744).

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All Publications

2003: Sergio De Munari; Alberto Cerri; Mauro Gobbini; Nicoletta Almirante; Leonardo Banfi; Giulio Carzana; Patrizia Ferrari; Giuseppe Marazzi; Rosella Micheletti; Antonio Schiavone; Simona Sputore; Marco Torri; Maria Pia Zappavigna; Piero Melloni
Structure-based design and synthesis of novel potent Na+,K+ -ATPase inhibitors derived from a 5alpha,14alpha-androstane scaffold as positive inotropic compounds.
Journal of medicinal chemistry 2003;46(17):3644-54.
2003: Patrizia Ferrari; Mara Ferrandi; Lucia Torielli; Paolo Barassi; Grazia Tripodi; Elena Minotti; Isabella Molinari; Piero Melloni; Giuseppe Bianchi
Antihypertensive compounds that modulate the Na-K pump.
Annals of the New York Academy of Sciences 2003;986():694-701.
2002: Rosella Micheletti; Giovan Giuseppe Mattera; Marcella Rocchetti; Antonio Schiavone; M F Loi; Antonio Zaza; R J P Gagnol; Sergio De Munari; Piero Melloni; Paolo Carminati; Giuseppe Bianchi; Patrizia Ferrari
Pharmacological profile of the novel inotropic agent (E,Z)-3-((2-aminoethoxy)imino)androstane-6,17-dione hydrochloride (PST2744).
The Journal of pharmacology and experimental therapeutics 2002;303(2):592-600.
2002: Alberto Cerri; Nicoletta Almirante; Paolo Barassi; Alessandra Benicchio; Sergio De Munari; Giuseppe Marazzi; Isabella Molinari; Fulvio Serra; Piero Melloni
Synthesis and inotropic activity of 1-(O-aminoalkyloximes) of perhydroindene derivatives as simplified digitalis-like compounds acting on the Na(+),K(+)-ATPase.
Journal of medicinal chemistry 2002;45(1):189-207.
2001: Mauro Gobbini; Paolo Barassi; Alberto Cerri; Sergio De Munari; G Fedrizzi; M Santagostino; Antonio Schiavone; Marco Torri; Piero Melloni
17 alpha-O-(aminoalkyl)oxime derivatives of 3 beta,14 beta-dihydroxy-5 beta-androstane and 3 beta-hydroxy-14-oxoseco-D-5 beta-androstane as inhibitors of Na(+),K(+)-ATPase at the digitalis receptor.
Journal of medicinal chemistry 2001;44(23):3821-30.
2000: Alberto Cerri; Nicoletta Almirante; Paolo Barassi; A Benicchio; G Fedrizzi; Patrizia Ferrari; Rosella Micheletti; L Quadri; E Ragg; R Rossi; M Santagostino; Antonio Schiavone; Fulvio Serra; Maria Pia Zappavigna; Piero Melloni
17beta-O-Aminoalkyloximes of 5beta-androstane-3beta,14beta-diol with digitalis-like activity: synthesis, cardiotonic activity, structure-activity relationships, and molecular modeling of the Na(+),K(+)-ATPase receptor.
Journal of medicinal chemistry 2000;43(12):2332-49.
1999: Patrizia Ferrari; Mara Ferrandi; Grazia Tripodi; Lucia Torielli; Gloria Padoani; Elena Minotti; Piero Melloni; Giuseppe Bianchi
PST 2238: A new antihypertensive compound that modulates Na,K-ATPase in genetic hypertension.
The Journal of pharmacology and experimental therapeutics 1999;288(3):1074-83.
1998: Mauro Gobbini; Giuseppe Marazzi; Gloria Padoani; L Quadri; L Valentino; Maria Pia Zappavigna; Piero Melloni
Synthesis and biological evaluation of 2-hydroxy derivatives of digitoxigenin and 3-epidigitoxigenin.
Bioorganic & medicinal chemistry 1998;6(10):1889-94.
1998: Sergio De Munari; Paolo Barassi; Alberto Cerri; G Fedrizzi; Mauro Gobbini; M Mabilia; Piero Melloni
A new approach to the design of novel inhibitors of Na+,K+-ATPase: 17alpha-substituted seco-D 5beta-androstane as cassaine analogues.
Journal of medicinal chemistry 1998;41(16):3033-40.
1998: Patrizia Ferrari; Lucia Torielli; Mara Ferrandi; Gloria Padoani; L Duzzi; Monica Florio; F Conti; Piero Melloni; L Vesci; N Corsico; Giuseppe Bianchi
PST2238: a new antihypertensive compound that antagonizes the long-term pressor effect of ouabain.
The Journal of pharmacology and experimental therapeutics 1998;285(1):83-94.
1997: Alberto Cerri; Fulvio Serra; Patrizia Ferrari; E Folpini; Gloria Padoani; Piero Melloni
Synthesis, cardiotonic activity, and structure-activity relationships of 17 beta-guanylhydrazone derivatives of 5 beta-androstane-3 beta, 14 beta-diol acting on the Na+,K(+)-ATPase receptor.
Journal of medicinal chemistry 1997;40(21):3484-8.
1997: L Quadri; Giuseppe Bianchi; Alberto Cerri; G Fedrizzi; Patrizia Ferrari; Mauro Gobbini; Piero Melloni; S Sputore; Marco Torri
17 beta-(3-furyl)-5 beta-androstane-3 beta, 14 beta, 17 alpha-triol (PST 2238). A very potent antihypertensive agent with a novel mechanism of action.
Journal of medicinal chemistry 1997;40(11):1561-4.
1996: Mauro Gobbini; A Benicchio; G Marazzi; Gloria Padoani; M Torri; Piero Melloni
Digitalis-like compounds: synthesis and biological evaluation of seco-D and D-homo derivatives.
Steroids 1996;61(10):572-82.
1996: L Quadri; Alberto Cerri; Patrizia Ferrari; E Folpini; M Mabilia; Piero Melloni
Synthesis and quantitative structure-activity relationship of 17 beta-(hydrazonomethyl)-5 beta-androstane-3 beta,14 beta-diol derivatives that bind to Na+,K(+)-ATPase receptor.
Journal of medicinal chemistry 1996;39(17):3385-93.
1991: Piero Melloni; C Banzatti; F Heidempergher; G Marazzi; S Ricciardi; F Vaghi; Mario Varasi
New 2-substituted 2,3,3a,4-tetrahydro-1H-imidazo[5,1-c] [1,4]benzoxazin-1-ones as alpha 2-adrenoceptor antagonists.
Farmaco (Società chimica italiana : 1989) 1991;46(9):1011-21.
1991: Anna Arnoldi; Lucio Merlini; M L Quadri; A Bonsignori; Piero Melloni; Mario Varasi
Synthesis and anticonvulsant activity of some benzopyranone imino derivatives of GABA and related compounds.
Farmaco (Società chimica italiana : 1989) 1991;46(5):629-38.
1990: Anna Arnoldi; A Bonsignori; Piero Melloni; Lucio Merlini; M L Quadri; A C Rossi; M Valsecchi
Synthesis and anticonvulsant and sedative-hypnotic activity of 4-(alkylimino)-2,3-dihydro-4H-1-benzopyrans and -benzothiopyrans.
Journal of medicinal chemistry 1990;33(10):2865-9.
1988: C Banzatti; N Carfagna; R Commisso; F Heidempergher; L Pegrassi; Piero Melloni
Preparation of 7-oxaaporphine derivatives and evaluation of their dopaminergic activity.
Journal of medicinal chemistry 1988;31(7):1466-71.
1984: C Banzatti; U Branzoli; P P Lovisolo; Piero Melloni; G Orsini; P Salvadori
Hypolipidemic activity of some derivatives of 6H-dibenzo[b,d]pyran.
Arzneimittel-Forschung 1984;34(8):864-9.