FIND

researchers

DISCOVER

relevant articles

PROMOTE

your research

now for free

Ian Mellor

Research Profile

Chemicals & Drugs

Living Beings

Procedures

Patch-Clamp Techniques

Anatomy

Physiology

Ion Channel Gating

Concepts & Ideas

Co-author Network

Publications

TOP 3
Richard J Wall; Martin Rose; J Craig Rowlands; Rana Bazzi; David R Bell; Alwyn Fernandes; Ian R Mellor
Fused mesoionic heterocyclic compounds are a new class of aryl hydrocarbon receptor (AhR) agonist of exceptional potency.
Richard J Wall; Valentina Onnis; Martin Rose; J Craig Rowlands; Gianfranco Balboni; David R Bell; Cenzo Congiu; Michael S Denison; Alwyn Fernandes; Guochun He; Ian R Mellor
Novel 2-amino-isoflavones exhibit aryl hydrocarbon receptor agonist or antagonist activity in a species/cell-specific context.
David W McClymont; John Harris; Ian R Mellor
Open-channel blockade is less effective on GluN3B than GluN3A subunit-containing NMDA receptors.

Register for free to view:

Visualized networks:

See your personal network in
sophisticated graphical views

GeoTargeted Searches:

Locate experts around the world
and connect with global collaborators

Research Profiles:

See the research activity
of experts around the globe

Geonetwork of Ian Mellor (preview)

Cities where this author has publications
Cities where co-authors of this author have publications

Flash Player Required

All Publications

2012: Richard J Wall; Martin Rose; J Craig Rowlands; Rana Bazzi; David R Bell; Alwyn Fernandes; Ian R Mellor
Fused mesoionic heterocyclic compounds are a new class of aryl hydrocarbon receptor (AhR) agonist of exceptional potency.
Toxicology 2012;302(2-3):140-5.
2012: Richard J Wall; Valentina Onnis; Martin Rose; J Craig Rowlands; Gianfranco Balboni; David R Bell; Cenzo Congiu; Michael S Denison; Alwyn Fernandes; Guochun He; Ian R Mellor
Novel 2-amino-isoflavones exhibit aryl hydrocarbon receptor agonist or antagonist activity in a species/cell-specific context.
Toxicology 2012;297(1-3):26-33.
2012: David W McClymont; John Harris; Ian R Mellor
Open-channel blockade is less effective on GluN3B than GluN3A subunit-containing NMDA receptors.
European journal of pharmacology 2012;686(1-3):22-31.
2011: Mark J Burton; T G E Davies; Ian R Duce; Linda M Field; Ian R Mellor; Martin S Williamson
Differential resistance of insect sodium channels with kdr mutations to deltamethrin, permethrin and DDT.
Insect biochemistry and molecular biology 2011;41(9):723-32.
2010: Ian R Mellor
The AMPA receptor as a therapeutic target: current perspectives and emerging possibilities.
Future medicinal chemistry 2010;2(5):877-91.
2009: Fang Peng; Ian R Mellor; Martin S Williamson; T G Emyr Davies; Linda M Field; Peter N R Usherwood
Single channel study of deltamethrin interactions with wild-type and mutated rat Na(V)1.2 sodium channels expressed in Xenopus oocytes.
Neurotoxicology 2009;30(3):358-67.
2007: Peter N R Usherwood; T G E Davies; Ian R Mellor; Andrias O O'Reilly; F Peng; H Vais; Bhupinder P S Khambay; Linda M Field; Martin S Williamson
Mutations in DIIS5 and the DIIS4-S5 linker of Drosophila melanogaster sodium channel define binding domains for pyrethroids and DDT.
FEBS letters 2007;581(28):5485-92.
2007: David Anderson; Tim Self; Ian R Mellor; Gareth Goh; Stephen J Hill; Chris Denning
Transgenic enrichment of cardiomyocytes from human embryonic stem cells.
Molecular therapy : the journal of the American Society of Gene Therapy 2007;15(11):2027-36.
2006: Cailean Clarkson; Ian R Mellor; Maja Lambery; Jerzy W Jaroszewski
5alpha-cardenolides from Kanahia laniflora inhibit ionotropic acetylcholine receptors.
Planta medica 2006;72(15):1418-20.
2006: Trine F Andersen; Denis B Tikhonov; Ulrik Bølcho; Konstantin Bolshakov; Jared K Nelson; Florentina Pluteanu; Ian R Mellor; Jan Egebjerg; Kristian Strømgaard
Uncompetitive antagonism of AMPA receptors: Mechanistic insights from studies of polyamine toxin derivatives.
Journal of medicinal chemistry 2006;49(18):5414-23.
2006: Christian A Olsen; Ian R Mellor; Petrine Wellendorph; Peter N R Usherwood; Matthias Witt; Henrik Franzyk; Jerzy W Jaroszewski
Tuning wasp toxin structure for nicotinic receptor antagonism: cyclohexylalanine-containing analogues as potent and voltage-dependent blockers.
ChemMedChem 2006;1(3):303-5.
2005: Samy Zalat; Shereen Elbana; Silvio Rizzoli; Justin O Schmidt; Ian R Mellor
Modulation of nicotinic acetylcholine and N-methyl-d-aspartate receptors by some Hymenopteran venoms.
Toxicon : official journal of the International Society on Toxinology 2005;46(3):282-90.
2005: Konstantin Bolshakov; K H Kim; N N Potapjeva; VE Gmiro; Denis B Tikhonov; Peter N R Usherwood; Ian R Mellor; Lev G Magazanik
Design of antagonists for NMDA and AMPA receptors.
Neuropharmacology 2005;49(2):144-55.
2005: Pauline Moore; Jane Ogilvie; Elisabeth Horridge; Ian R Mellor; Richard H Clothier
The development of an innervated epithelial barrier model using a human corneal cell line and ND7/23 sensory neurons.
European journal of cell biology 2005;84(5):581-92.
2005: Malene R Jørgensen; Christian A Olsen; Ian R Mellor; Peter N R Usherwood; Matthias Witt; Henrik Franzyk; Jerzy W Jaroszewski
The effects of conformational constraints and steric bulk in the amino acid moiety of philanthotoxins on AMPAR antagonism.
Journal of medicinal chemistry 2005;48(1):56-70.
2004: Ian R Mellor; Jane Ogilvie; Florentina Pluteanu; Richard H Clothier; Terence L Parker; Michela Rosini; Anna Minarini; Vincenzo Tumiatti; Carlo Melchiorre
Methoctramine analogues inhibit responses to capsaicin and protons in rat dorsal root ganglion neurons.
European journal of pharmacology 2004;505(1-3):37-50.
2004: Kristian Strømgaard; Ian R Mellor
AMPA receptor ligands: synthetic and pharmacological studies of polyamines and polyamine toxins.
Medicinal research reviews 2004;24(5):589-620.
2004: Denis B Tikhonov; Ian R Mellor; Peter N R Usherwood
Modeling noncompetitive antagonism of a nicotinic acetylcholine receptor.
Biophysical journal 2004;87(1):159-70.
2004: Ian R Mellor; Peter N R Usherwood
Targeting ionotropic receptors with polyamine-containing toxins.
Toxicon : official journal of the International Society on Toxinology 2004;43(5):493-508.
2003: Tim J Brier; Ian R Mellor; Denis B Tikhonov; Ioana Neagoe; Zuoyi Shao; Matt J Brierley; Kristian Strømgaard; Jerzy W Jaroszewski; Povl Krogsgaard-Larsen; Peter N R Usherwood
Contrasting actions of philanthotoxin-343 and philanthotoxin-(12) on human muscle nicotinic acetylcholine receptors.
Molecular pharmacology 2003;64(4):954-64.
2003: Ian R Mellor; Tim J Brier; Florentina Pluteanu; Kristian Strømgaard; A Saghyan; N Eldursi; Matt J Brierley; Kim Andersen; Jerzy W Jaroszewski; Povl Krogsgaard-Larsen; Peter N R Usherwood
Modification of the philanthotoxin-343 polyamine moiety results in different structure-activity profiles at muscle nicotinic ACh, NMDA and AMPA receptors.
Neuropharmacology 2003;44(1):70-80.
2002: Kristian Strømgaard; Ian R Mellor; Kim Andersen; Ioana Neagoe; Florentina Pluteanu; Peter N R Usherwood; Povl Krogsgaard-Larsen; Jerzy W Jaroszewski
Solid-phase synthesis and pharmacological evaluation of analogues of PhTX-12-A potent and selective nicotinic acetylcholine receptor antagonist.
Bioorganic & medicinal chemistry letters 2002;12(8):1159-62.
2001: M Gabriele Bixel; Christoph Weise; Maria Laura Bolognesi; Michela Rosini; M J Brierly; Ian R Mellor; Peter N R Usherwood; Carlo Melchiorre; Ferdinand Hucho
Location of the polyamine binding site in the vestibule of the nicotinic acetylcholine receptor ion channel.
The Journal of biological chemistry 2001;276(9):6151-60.
2000: Kristian Strømgaard; Tim J Brier; Kim Andersen; Ian R Mellor; A Saghyan; Denis B Tikhonov; Peter N R Usherwood; Povl Krogsgaard-Larsen; Jerzy W Jaroszewski
Solid-phase synthesis and biological evaluation of a combinatorial library of philanthotoxin analogues.
Journal of medicinal chemistry 2000;43(23):4526-33.
2000: Kristian Strømgaard; Inga Bjørnsdottir; Kim Andersen; Matt J Brierley; S Rizoli; N Eldursi; Ian R Mellor; Peter N R Usherwood; Steen H Hansen; Povl Krogsgaard-Larsen; Jerzy W Jaroszewski
Solid phase synthesis and biological evaluation of enantiomerically pure wasp toxin analogues PhTX-343 and PhTX-12.
Chirality 2000;12(2):93-102.
2000: Denis B Tikhonov; Lev G Magazanik; Ian R Mellor; Peter N R Usherwood
Possible influence of intramolecular hydrogen bonds on the three-dimensional structure of polyamine amides and their interaction with ionotropic glutamate receptors.
Receptors & channels 2000;7(3):227-36.
1999: K Stromgaard; Matt J Brierley; Kim Andersen; Frank A Sløk; Ian R Mellor; Peter N R Usherwood; Povl Krogsgaard-Larsen; Jerzy W Jaroszewski
Analogues of neuroactive polyamine wasp toxins that lack inner basic sites exhibit enhanced antagonism toward a muscle-type mammalian nicotinic acetylcholine receptor.
Journal of medicinal chemistry 1999;42(25):5224-34.
1999: Michela Rosini; Roberta Budriesi; M Gabriele Bixel; Maria Laura Bolognesi; Alberto Chiarini; Ferdinand Hucho; P Krogsgaard-Larsen; Ian R Mellor; Anna Minarini; Vincenzo Tumiatti; Peter N R Usherwood; Carlo Melchiorre
Design, synthesis, and biological evaluation of symmetrically and unsymmetrically substituted methoctramine-related polyamines as muscular nicotinic receptor noncompetitive antagonists.
Journal of medicinal chemistry 1999;42(25):5212-23.
1998: Zuoyi Shao; Ian R Mellor; Matt J Brierley; J Harris; Peter N R Usherwood
Potentiation and inhibition of nicotinic acetylcholine receptors by spermine in the TE671 human muscle cell line.
The Journal of pharmacology and experimental therapeutics 1998;286(3):1269-76.
1998: Mikhail Soloviev; K Abutidze; Ian R Mellor; P Streit; E V Grishin; Peter N R Usherwood; Eric A Barnard
Plasticity of agonist binding sites in hetero-oligomers of the unitary glutamate receptor subunit XenU1.
Journal of neurochemistry 1998;71(3):991-1001.
1997: Lev G Magazanik; SL Buldakova; MV Samoilova; VE Gmiro; Ian R Mellor; Peter N R Usherwood
Block of open channels of recombinant AMPA receptors and native AMPA/kainate receptors by adamantane derivatives.
The Journal of physiology 1997;505 ( Pt 3)():655-63.
1997: Simon R Tomlinson; S Kirwin; Ian R Mellor; J Harris; MK Mundey; Matt J Brierley; David R Bell; Peter N R Usherwood
Interaction of a polyamine amide wasp toxin with cloned and mutant glutamate receptors.
Biochemical Society transactions 1997;25(3):551S.
1996: Mikhail Soloviev; Matt J Brierley; Zuoyi Shao; Ian R Mellor; Tatyana M Volkova; Rajender K Kamboj; H Ishimaru; H Sudan; J Harris; R L Foldes; E V Grishin; Peter N R Usherwood; Eric A Barnard
Functional expression of a recombinant unitary glutamate receptor from Xenopus, which contains N-methyl-D-aspartate (NMDA) and non-NMDA receptor subunits.
The Journal of biological chemistry 1996;271(51):32572-9.
1996: E Gorczynska; P L Huddie; B A Miller; Ian R Mellor; H Vais; R L Ramsey; Peter N R Usherwood
Potassium channels of adult locust (Schistocerca gregaria) muscle.
Pflügers Archiv : European journal of physiology 1996;432(4):597-606.
1995: H L Sudan; C J Kerry; Ian R Mellor; Seok Ki Choi; D Huang; K Nakanishi; Peter N R Usherwood
The action of philanthotoxin-343 and photolabile analogues on locust (Schistocerca gregaria) muscle.
Invertebrate neuroscience : IN 1995;1(2):159-72.
1995: M Spassova; Ian R Mellor; A G Petrov; Kenneth A Beattie; Geoffrey A Codd; H Vais; Peter N R Usherwood
Pores formed in lipid bilayers and in native membranes by nodularin, a cyanobacterial toxin.
European biophysics journal : EBJ 1995;24(2):69-76.
1993: C J Kerry; H L Sudan; K Abutidze; Ian R Mellor; Eric A Barnard; Peter N R Usherwood
Reconstitution of glutamate receptor proteins purified from Xenopus central nervous system into artificial bilayers.
Molecular pharmacology 1993;44(1):142-52.
1993: Peter N R Usherwood; Ian R Mellor; L Breedon; Robert Justin Harvey; Eric A Barnard; MG Darlison
Channels formed by M2 peptides of a putative glutamate receptor subunit of locust.
EXS 1993;63():241-9.
1992: Jeremy M Henley; A Ambrosini; Daniel Rodriguez-Ithurralde; H Sudan; P Brackley; C Kerry; Ian R Mellor; K Abutidze; Peter N R Usherwood; Eric A Barnard
Purified unitary kainate/alpha-amino-3-hydroxy-5-methylisooxazole-propionate (AMPA) and kainate/AMPA/N-methyl-D-aspartate receptors with interchangeable subunits.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(11):4806-10.
1991: M S Sansom; I D Kerr; Ian R Mellor
Ion channels formed by amphipathic helical peptides. A molecular modelling study.
European biophysics journal : EBJ 1991;20(4):229-40.
1990: Ian R Mellor; M S Sansom
Ion-channel properties of mastoparan, a 14-residue peptide from wasp venom, and of MP3, a 12-residue analogue.
Proceedings of the Royal Society of London. Series B, Containing papers of a Biological character. Royal Society (Great Britain) 1990;239(1296):383-400.
1988: Ian R Mellor; D H Thomas; M S Sansom
Properties of ion channels formed by Staphylococcus aureus delta-toxin.
Biochimica et biophysica acta 1988;942(2):280-94.