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Thomas Bayer

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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TOP 3
Christensen Ditte Z; Bayer Thomas A; Wirths Oliver
Formic acid is essential for immunohistochemical detection of aggregated intraneuronal Abeta peptides in mouse models of Alzheimer's disease.
Wirths Oliver; Breyhan Henning; Cynis Holger; Schilling Stephan; Demuth Hans-Ulrich; Bayer Thomas A
Intraneuronal pyroglutamate-Abeta 3-42 triggers neurodegeneration and lethal neurological deficits in a transgenic mouse model.
Breyhan Henning; Wirths Oliver; Duan Kailai; Marcello Andrea; Rettig Jens; Bayer Thomas A
APP/PS1KI bigenic mice develop early synaptic deficits and hippocampus atrophy.

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All Publications

2009: Christensen Ditte Z; Bayer Thomas A; Wirths Oliver
Formic acid is essential for immunohistochemical detection of aggregated intraneuronal Abeta peptides in mouse models of Alzheimer's disease.
Brain research 2009;1301():116-25.
2009: Wirths Oliver; Breyhan Henning; Cynis Holger; Schilling Stephan; Demuth Hans-Ulrich; Bayer Thomas A
Intraneuronal pyroglutamate-Abeta 3-42 triggers neurodegeneration and lethal neurological deficits in a transgenic mouse model.
Acta neuropathologica 2009;118(4):487-96.
2009: Breyhan Henning; Wirths Oliver; Duan Kailai; Marcello Andrea; Rettig Jens; Bayer Thomas A
APP/PS1KI bigenic mice develop early synaptic deficits and hippocampus atrophy.
Acta neuropathologica 2009;117(6):677-85.
2009: Treiber Carina; Quadir Mohiuddin Abdul; Voigt Philipp; Radowski Michal; Xu Shangjie; Munter Lisa-Marie; Bayer Thomas A; Schaefer Michael; Haag Rainer; Multhaup Gerd
Cellular copper import by nanocarrier systems, intracellular availability, and effects on amyloid beta peptide secretion.
Biochemistry 2009;48(20):4273-84.
2008: Christensen Ditte Zerlang; Kraus Sophie Luise; Flohr Antonius; Cotel Marie-Caroline; Wirths Oliver; Bayer Thomas A
Transient intraneuronal A beta rather than extracellular plaque pathology correlates with neuron loss in the frontal cortex of APP/PS1KI mice.
Acta neuropathologica 2008;116(6):647-55.
2008: Kessler Holger; Pajonk Frank-Gerald; Bach Daniela; Schneider-Axmann Thomas; Falkai Peter; Herrmann Wolfgang; Multhaup Gerd; Wiltfang Jens; Schäfer Stephanie; Wirths Oliver; Bayer Thomas A
Effect of copper intake on CSF parameters in patients with mild Alzheimer's disease: a pilot phase 2 clinical trial.
Journal of neural transmission (Vienna, Austria : 1996) 2008;115(12):1651-9.
2008: Kessler Holger; Bayer Thomas A; Bach Daniela; Schneider-Axmann Thomas; Supprian Tillmann; Herrmann Wolfgang; Haber Manfred; Multhaup Gerd; Falkai Peter; Pajonk Frank-Gerald
Intake of copper has no effect on cognition in patients with mild Alzheimer's disease: a pilot phase 2 clinical trial.
Journal of neural transmission (Vienna, Austria : 1996) 2008;115(8):1181-7.
2008: Cotel Marie-Caroline; Bayer Thomas A; Wirths Oliver
Age-dependent loss of dentate gyrus granule cells in APP/PS1KI mice.
Brain research 2008;1222():207-13.
2008: Wirths Oliver; Breyhan Henning; Schäfer Stephanie; Roth Christian; Bayer Thomas A
Deficits in working memory and motor performance in the APP/PS1ki mouse model for Alzheimer's disease.
Neurobiology of aging 2008;29(6):891-901.
2008: Bayer T A; Wirths O
Review on the APP/PS1KI mouse model: intraneuronal Abeta accumulation triggers axonopathy, neuron loss and working memory impairment.
Genes, brain, and behavior 2008;7 Suppl 1():6-11.
2008: Wirths O; Bayer T A
Motor impairment in Alzheimer's disease and transgenic Alzheimer's disease mouse models.
Genes, brain, and behavior 2008;7 Suppl 1():1-5.
2008: Bayer Thomas A; Breyhan Henning; Duan Kailai; Rettig Jens; Wirths Oliver
Intraneuronal beta-amyloid is a major risk factor--novel evidence from the APP/PS1KI mouse model.
Neuro-degenerative diseases 2008;5(3-4):140-2.
2007: Wirths Oliver; Weis Joachim; Kayed Rakez; Saido Takaomi C; Bayer Thomas A
Age-dependent axonal degeneration in an Alzheimer mouse model.
Neurobiology of aging 2007;28(11):1689-99.
2007: Wirths Oliver; Thelen Karin M; Lütjohann Dieter; Falkai Peter; Bayer Thomas A
Altered cholesterol metabolism in APP695-transfected neuroblastoma cells.
Brain research 2007;1152():209-14.
2007: Schäfer Stephanie; Pajonk Frank-Gerald; Multhaup Gerd; Bayer Thomas A
Copper and clioquinol treatment in young APP transgenic and wild-type mice: effects on life expectancy, body weight, and metal-ion levels.
Journal of molecular medicine (Berlin, Germany) 2007;85(4):405-13.
2007: Schäfer S; Wirths O; Multhaup G; Bayer T A
Gender dependent APP processing in a transgenic mouse model of Alzheimer's disease.
Journal of neural transmission (Vienna, Austria : 1996) 2007;114(3):387-94.
2006: Kessler H; Pajonk F-G; Meisser P; Schneider-Axmann T; Hoffmann K-H; Supprian T; Herrmann W; Obeid R; Multhaup G; Falkai P; Bayer T A
Cerebrospinal fluid diagnostic markers correlate with lower plasma copper and ceruloplasmin in patients with Alzheimer's disease.
Journal of neural transmission (Vienna, Austria : 1996) 2006;113(11):1763-9.
2006: Bayer T A; Schäfer S; Breyhan H; Wirths O; Treiber C; Multhaup G
A vicious circle: role of oxidative stress, intraneuronal Abeta and Cu in Alzheimer's disease.
Clinical neuropathology 2006;25(4):163-71.
2006: Thelen K M; Falkai P; Bayer T A; Lütjohann D
Cholesterol synthesis rate in human hippocampus declines with aging.
Neuroscience letters 2006;403(1-2):15-9.
2006: Wirths Oliver; Weis Joachim; Szczygielski Jacek; Multhaup Gerd; Bayer Thomas A
Axonopathy in an APP/PS1 transgenic mouse model of Alzheimer's disease.
Acta neuropathologica 2006;111(4):312-9.
2006: Wirths Oliver; Thelen Karin; Breyhan Henning; Luzón-Toro Berta; Hoffmann Karl-Heinz; Falkai Peter; Lütjohann Dieter; Bayer Thomas A
Decreased plasma cholesterol levels during aging in transgenic mouse models of Alzheimer's disease.
Experimental gerontology 2006;41(2):220-4.
2005: Szczygielski J; Mautes A; Steudel W I; Falkai P; Bayer T A; Wirths O
Traumatic brain injury: cause or risk of Alzheimer's disease? A review of experimental studies.
Journal of neural transmission (Vienna, Austria : 1996) 2005;112(11):1547-64.
2005: Pajonk Frank-Gerald; Kessler Holger; Supprian Tillmann; Hamzei Pegah; Bach Daniela; Schweickhardt Janina; Herrmann Wolfgang; Obeid Rima; Simons Andreas; Falkai Peter; Multhaup Gerd; Bayer Thomas A
Cognitive decline correlates with low plasma concentrations of copper in patients with mild to moderate Alzheimer's disease.
Journal of Alzheimer's disease : JAD 2005;8(1):23-7.
2005: Rutten Bart P F; Van der Kolk Nicolien M; Schafer Stephanie; van Zandvoort Marc A M J; Bayer Thomas A; Steinbusch Harry W M; Schmitz Christoph
Age-related loss of synaptophysin immunoreactive presynaptic boutons within the hippocampus of APP751SL, PS1M146L, and APP751SL/PS1M146L transgenic mice.
The American journal of pathology 2005;167(1):161-73.
2005: Schuessel Katrin; Schäfer Stephanie; Bayer Thomas A; Czech Christian; Pradier Laurent; Müller-Spahn Franz; Müller Walter E; Eckert Anne
Impaired Cu/Zn-SOD activity contributes to increased oxidative damage in APP transgenic mice.
Neurobiology of disease 2005;18(1):89-99.
2004: Treiber Carina; Simons Andreas; Strauss Markus; Hafner Mathias; Cappai Roberto; Bayer Thomas A; Multhaup Gerd
Clioquinol mediates copper uptake and counteracts copper efflux activities of the amyloid precursor protein of Alzheimer's disease.
The Journal of biological chemistry 2004;279(50):51958-64.
2004: Wirths Oliver; Multhaup Gerd; Bayer Thomas A
A modified beta-amyloid hypothesis: intraneuronal accumulation of the beta-amyloid peptide--the first step of a fatal cascade.
Journal of neurochemistry 2004;91(3):513-20.
2004: Casas Caty; Sergeant Nicolas; Itier Jean-Michel; Blanchard Véronique; Wirths Oliver; van der Kolk Nicolien; Vingtdeux Valérie; van de Steeg Evita; Ret Gwenaëlle; Canton Thierry; Drobecq Hervé; Clark Allan; Bonici Bruno; Delacourte André; Benavides Jesús; Schmitz Christoph; Tremp Günter; Bayer Thomas A; Benoit Patrick; Pradier Laurent
Massive CA1/2 neuronal loss with intraneuronal and N-terminal truncated Abeta42 accumulation in a novel Alzheimer transgenic model.
The American journal of pathology 2004;165(4):1289-300.
2004: Schmechel Ariane; Strauss Markus; Schlicksupp Andrea; Pipkorn Rüdiger; Haass Christian; Bayer Thomas A; Multhaup Gerd
Human BACE forms dimers and colocalizes with APP.
The Journal of biological chemistry 2004;279(38):39710-7.
2004: Schmitz Christoph; Rutten Bart P F; Pielen Andrea; Schäfer Stephanie; Wirths Oliver; Tremp Günter; Czech Christian; Blanchard Veronique; Multhaup Gerd; Rezaie Payam; Korr Hubert; Steinbusch Harry W M; Pradier Laurent; Bayer Thomas A
Hippocampal neuron loss exceeds amyloid plaque load in a transgenic mouse model of Alzheimer's disease.
The American journal of pathology 2004;164(4):1495-502.
2003: Blanchard Véronique; Moussaoui Saliha; Czech Christian; Touchet Nathalie; Bonici Bruno; Planche Michel; Canton Thierry; Jedidi Iness; Gohin Micheline; Wirths Oliver; Bayer Thomas A; Langui Dominique; Duyckaerts Charles; Tremp Günter; Pradier Laurent
Time sequence of maturation of dystrophic neurites associated with Abeta deposits in APP/PS1 transgenic mice.
Experimental neurology 2003;184(1):247-63.
2003: Bayer Thomas A; Schäfer Stephanie; Simons Andreas; Kemmling André; Kamer Thomas; Tepest Ralf; Eckert Anne; Schüssel Katrin; Eikenberg Oliver; Sturchler-Pierrat Christine; Abramowski Dorothee; Staufenbiel Matthias; Multhaup Gerd
Dietary Cu stabilizes brain superoxide dismutase 1 activity and reduces amyloid Abeta production in APP23 transgenic mice.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(24):14187-92.
2003: Schmechel Ariane; Zentgraf Hanswalter; Scheuermann Stefan; Fritz Guenter; Pipkorn Rüdiger; Reed Jennifer; Beyreuther Konrad; Bayer Thomas A; Multhaup Gerd
Alzheimer beta-amyloid homodimers facilitate A beta fibrillization and the generation of conformational antibodies.
The Journal of biological chemistry 2003;278(37):35317-24.
2003: Rutten Bart P F; Wirths Oliver; Van de Berg Wilma D J; Lichtenthaler Stefan F; Vehoff Jochen; Steinbusch Harry W M; Korr Hubert; Beyreuther Konrad; Multhaup Gerd; Bayer Thomas A; Schmitz Christoph
No alterations of hippocampal neuronal number and synaptic bouton number in a transgenic mouse model expressing the beta-cleaved C-terminal APP fragment.
Neurobiology of disease 2003;12(2):110-20.
2003: Wirths Oliver; Bayer Thomas A
Alpha-synuclein, Abeta and Alzheimer's disease.
Progress in neuro-psychopharmacology & biological psychiatry 2003;27(1):103-8.
2002: Wirths Oliver; Multhaup Gerd; Czech Christian; Feldmann Nicole; Blanchard Véronique; Tremp Günter; Beyreuther Konrad; Pradier Laurent; Bayer Thomas A
Intraneuronal APP/A beta trafficking and plaque formation in beta-amyloid precursor protein and presenilin-1 transgenic mice.
Brain pathology (Zurich, Switzerland) 2002;12(3):275-86.
2002: Simons Andreas; Ruppert Thomas; Schmidt Carsten; Schlicksupp Andrea; Pipkorn Rüdiger; Reed Jennifer; Masters Colin L; White Anthony R; Cappai Roberto; Beyreuther Konrad; Bayer Thomas A; Multhaup Gerd
Evidence for a copper-binding superfamily of the amyloid precursor protein.
Biochemistry 2002;41(30):9310-20.
2002: Lütjohann Dieter; Brzezinka Andreas; Barth Esther; Abramowski Dorothee; Staufenbiel Matthias; von Bergmann Klaus; Beyreuther Konrad; Multhaup Gerd; Bayer Thomas A
Profile of cholesterol-related sterols in aged amyloid precursor protein transgenic mouse brain.
Journal of lipid research 2002;43(7):1078-85.
2002: Multhaup Gerd; Scheuermann Stefan; Schlicksupp Andrea; Simons Andreas; Strauss Markus; Kemmling André; Oehler Christian; Cappai Roberto; Pipkorn Rüdiger; Bayer Thomas A
Possible mechanisms of APP-mediated oxidative stress in Alzheimer's disease.
Free radical biology & medicine 2002;33(1):45-51.
2001: Wirths O; Multhaup G; Czech C; Blanchard V; Tremp G; Pradier L; Beyreuther K; Bayer T A
Reelin in plaques of beta-amyloid precursor protein and presenilin-1 double-transgenic mice.
Neuroscience letters 2001;316(3):145-8.
2001: Scheuermann S; Hambsch B; Hesse L; Stumm J; Schmidt C; Beher D; Bayer T A; Beyreuther K; Multhaup G
Homodimerization of amyloid precursor protein and its implication in the amyloidogenic pathway of Alzheimer's disease.
The Journal of biological chemistry 2001;276(36):33923-9.
2001: Wirths O; Multhaup G; Czech C; Blanchard V; Moussaoui S; Tremp G; Pradier L; Beyreuther K; Bayer T A
Intraneuronal Abeta accumulation precedes plaque formation in beta-amyloid precursor protein and presenilin-1 double-transgenic mice.
Neuroscience letters 2001;306(1-2):116-20.
2001: Weggen S; Preuss U; Pietsch T; Hilger N; Klawitz I; Scheidtmann K H; Wiestler O D; Bayer T A
Identification of amplified genes from SV40 large T antigen-induced rat PNET cell lines by subtractive cDNA analysis and radiation hybrid mapping.
Oncogene 2001;20(16):2023-31.
2001: Bayer T A; Wirths O; Majtényi K; Hartmann T; Multhaup G; Beyreuther K; Czech C
Key factors in Alzheimer's disease: beta-amyloid precursor protein processing, metabolism and intraneuronal transport.
Brain pathology (Zurich, Switzerland) 2001;11(1):1-11.
2000: Wirths O; Weickert S; Majtenyi K; Havas L; Kahle P J; Okochi M; Haass C; Multhaup G; Beyreuther K; Bayer T A
Lewy body variant of Alzheimer's disease: alpha-synuclein in dystrophic neurites of A beta plaques.
Neuroreport 2000;11(17):3737-41.
2000: Bayer T A; Schramm M; Feldmann N; Knable M B; Falkai P
Antidepressant drug exposure is associated with mRNA levels of tyrosine receptor kinase B in major depressive disorder.
Progress in neuro-psychopharmacology & biological psychiatry 2000;24(6):881-8.
2000: Ishii K; Muelhauser F; Liebl U; Picard M; Kühl S; Penke B; Bayer T; Wiessler M; Hennerici M; Beyreuther K; Hartmann T; Fassbender K
Subacute NO generation induced by Alzheimer's beta-amyloid in the living brain: reversal by inhibition of the inducible NO synthase.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2000;14(11):1485-9.
2000: Block W; Bayer T A; Tepest R; Träber F; Rietschel M; Müller D J; Schulze T G; Honer W G; Maier W; Schild H H; Falkai P
Decreased frontal lobe ratio of N-acetyl aspartate to choline in familial schizophrenia: a proton magnetic resonance spectroscopy study.
Neuroscience letters 2000;289(2):147-51.
2000: Weggen S; Bayer T A; von Deimling A; Reifenberger G; von Schweinitz D; Wiestler O D; Pietsch T
Low frequency of SV40, JC and BK polyomavirus sequences in human medulloblastomas, meningiomas and ependymomas.
Brain pathology (Zurich, Switzerland) 2000;10(1):85-92.
2000: Vogeley K; Schneider-Axmann T; Pfeiffer U; Tepest R; Bayer T A; Bogerts B; Honer W G; Falkai P
Disturbed gyrification of the prefrontal region in male schizophrenic patients: A morphometric postmortem study.
The American journal of psychiatry 2000;157(1):34-9.
1999: Bayer T A; Jäkälä P; Hartmann T; Egensperger R; Buslei R; Falkai P; Beyreuther K
Neural expression profile of alpha-synuclein in developing human cortex.
Neuroreport 1999;10(13):2799-803.
1999: Bayer T A; Buslei R; Havas L; Falkai P
Evidence for activation of microglia in patients with psychiatric illnesses.
Neuroscience letters 1999;271(2):126-8.
1999: Bayer T A; Thier M; Roeb E; Breuer B; Weggen S; Wiestler O D; Weis J
Migratory potential of transplantable neural tumor cell lines.
Acta neuropathologica 1999;97(6):607-12.
1999: Bayer T A; Jäkälä P; Hartmann T; Havas L; McLean C; Culvenor J G; Li Q X; Masters C L; Falkai P; Beyreuther K
Alpha-synuclein accumulates in Lewy bodies in Parkinson's disease and dementia with Lewy bodies but not in Alzheimer's disease beta-amyloid plaque cores.
Neuroscience letters 1999;266(3):213-6.
1999: Diehlmann A; Ida N; Weggen S; Grünberg J; Haass C; Masters C L; Bayer T A; Beyreuther K
Analysis of presenilin 1 and presenilin 2 expression and processing by newly developed monoclonal antibodies.
Journal of neuroscience research 1999;56(4):405-19.
1999: Salewski H; Bayer T A; Eidhoff U; Preuss U; Weggen S; Scheidtmann K H
Increased oncogenicity of subclones of SV40 large T-induced neuroectodermal tumor cell lines after loss of large T expression and concomitant mutation in p53.
Cancer research 1999;59(8):1980-6.
1999: Falkai P; Honer W G; David S; Bogerts B; Majtenyi C; Bayer T A
No evidence for astrogliosis in brains of schizophrenic patients. A post-mortem study.
Neuropathology and applied neurobiology 1999;25(1):48-53.
1999: Egensperger R; Weggen S; Ida N; Multhaup G; Schnabel R; Beyreuther K; Bayer T A
Reverse relationship between beta-amyloid precursor protein and beta-amyloid peptide plaques in Down's syndrome versus sporadic/familial Alzheimer's disease.
Acta neuropathologica 1999;97(2):113-8.
1999: Schramm M; Falkai P; Pietsch T; Neidt I; Egensperger R; Bayer T A
Neural expression profile of Elav-like genes in human brain.
Clinical neuropathology 1999;18(1):17-22.
1999: Schramm M; Falkai P; Tepest R; Schneider-Axmann T; Przkora R; Waha A; Pietsch T; Bonte W; Bayer T A
Stability of RNA transcripts in post-mortem psychiatric brains.
Journal of neural transmission (Vienna, Austria : 1996) 1999;106(3-4):329-35.
1998: Schramm M; Falkai P; Feldmann N; Knable M B; Bayer T A
Reduced tyrosine kinase receptor C mRNA levels in the frontal cortex of patients with schizophrenia.
Neuroscience letters 1998;257(2):65-8.
1998: Weggen S; Diehlmann A; Buslei R; Beyreuther K; Bayer T A
Prominent expression of presenilin-1 in senile plaques and reactive astrocytes in Alzheimer's disease brain.
Neuroreport 1998;9(14):3279-83.
1998: Przkora R; Falkai P; von Deimling A; Wiestler O D; Albus M; Rietschel M; Maier W; Bayer T A
Analysis of a polymorphism in the tuberous sclerosis (TSC2) gene does not predispose to schizophrenia.
European archives of psychiatry and clinical neuroscience 1998;248(6):314-5.
1997: Bayer T A; Paliga K; Weggen S; Wiestler O D; Beyreuther K; Multhaup G
Amyloid precursor-like protein 1 accumulates in neuritic plaques in Alzheimer's disease.
Acta neuropathologica 1997;94(6):519-24.
1997: Weggen S; Bayer T A; Koch A; Salewski H; Scheidtmann K H; Pietsch T; Wiestler O D
Characterization of neural cell lines derived from SV40 large T-induced primitive neuroectodermal tumors.
Brain pathology (Zurich, Switzerland) 1997;7(2):731-9.
1996: Bayer T A; Fossgreen A; Czech C; Beyreuther K; Wiestler O D
Plaque formation in brain transplants exposed to human beta-amyloid precursor protein 695.
Acta neuropathologica 1996;92(2):130-7.
1995: Albrecht S; Bayer T A; Kraus J A; Pietsch T
Transthyretin expression in medulloblastomas and medulloblastoma cell lines.
Neuropathology and applied neurobiology 1995;21(5):399-409.
1995: Bayer T A; Wiestler O D; Wolf H K
Hippocampal loss of N-methyl-D-aspartate receptor subunit 1 mRNA in chronic temporal lobe epilepsy.
Acta neuropathologica 1995;89(5):446-50.

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Thomas Bayer

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