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Ronald Melnick

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Bradley J Collins; Matthew D Stout; Keith E Levine; Grace E Kissling; Ronald L Melnick; Timothy R Fennell; Ramsey Walden; Kamal Abdo; John B Pritchard; Reshan A Fernando; Leo T Burka; Michelle J Hooth
Exposure to hexavalent chromium resulted in significantly higher tissue chromium burden compared with trivalent chromium following similar oral doses to male F344/N rats and female B6C3F1 mice.
Matthew D Stout; Ronald A Herbert; Grace E Kissling; Bradley J Collins; Gregory S Travlos; Kristine L Witt; Ronald L Melnick; Kamal Abdo; David E Malarkey; Michelle J Hooth
Hexavalent chromium is carcinogenic to F344/N rats and B6C3F1 mice after chronic oral exposure.
Ronald L Melnick; Kristina A Thayer; John R Bucher
Conflicting views on chemical carcinogenesis arising from the design and evaluation of rodent carcinogenicity studies.

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2010: Bradley J Collins; Matthew D Stout; Keith E Levine; Grace E Kissling; Ronald L Melnick; Timothy R Fennell; Ramsey Walden; Kamal Abdo; John B Pritchard; Reshan A Fernando; Leo T Burka; Michelle J Hooth
Exposure to hexavalent chromium resulted in significantly higher tissue chromium burden compared with trivalent chromium following similar oral doses to male F344/N rats and female B6C3F1 mice.
Toxicological sciences : an official journal of the Society of Toxicology 2010;118(2):368-79.
2009: Matthew D Stout; Ronald A Herbert; Grace E Kissling; Bradley J Collins; Gregory S Travlos; Kristine L Witt; Ronald L Melnick; Kamal Abdo; David E Malarkey; Michelle J Hooth
Hexavalent chromium is carcinogenic to F344/N rats and B6C3F1 mice after chronic oral exposure.
Environmental health perspectives 2009;117(5):716-22.
2008: Ronald L Melnick; Kristina A Thayer; John R Bucher
Conflicting views on chemical carcinogenesis arising from the design and evaluation of rodent carcinogenicity studies.
Environmental health perspectives 2008;116(1):130-5.
2007: Thai-Vu T Ton; Hue-Hua L Hong; Theodora R Devereux; Ronald L Melnick; Robert C Sills; Yongbaek Kim
Evaluation of genetic alterations in cancer-related genes in lung and brain tumors from B6C3F1 mice exposed to 1,3-butadiene or chloroprene.
Chemico-biological interactions 2007;166(1-3):112-20.
2007: Ronald L Melnick; Abraham Nyska; Paul M Foster; Joseph H Roycroft; Grace E Kissling
Toxicity and carcinogenicity of the water disinfection byproduct, dibromoacetic acid, in rats and mice.
Toxicology 2007;230(2-3):126-36.
2006: Kristina A Thayer; Ronald L Melnick; James Huff; Kathy Burns; Devra Davis
Hormesis: a new religion?
Environmental health perspectives 2006;114(11):A632-3.
2005: Kristina A Thayer; Ronald L Melnick; Kathy Burns; Devra Davis; James Huff
Fundamental flaws of hormesis for public health decisions.
Environmental health perspectives 2005;113(10):1271-6.
2005: Ronald L Melnick
A Daubert motion: a legal strategy to exclude essential scientific evidence in toxic tort litigation.
American journal of public health 2005;95 Suppl 1():S30-4.
2005: Yongbaek Kim; Hue-Hua L Hong; Yan Lachat; Natasha P Clayton; Theodora R Devereux; Ronald L Melnick; Monika E Hegi; Robert C Sills
Genetic alterations in brain tumors following 1,3-butadiene exposure in B6C3F1 mice.
Toxicologic pathology 2005;33(3):307-12.
2004: Ronald L Melnick; James Huff
Testing toxic pesticides in humans: health risks with no health benefits.
Environmental health perspectives 2004;112(8):A459-61.
2004: James Huff; Ronald L Melnick; Lorenzo Tomatis; Joseph LaDou; Daniel Teitelbaum
Trichloroethylene and cancers in humans.
Toxicology 2004;197(2):185-7.
2003: Ronald L Melnick; Charlotte Brody; Joseph DiGangi; James Huff
The IARC evaluation of DEHP excludes key papers demonstrating carcinogenic effects.
International journal of occupational and environmental health 2003;9(4):400-2.
2003: Ronald L Melnick; Freya Kamel; James Huff
Declaring chemicals "not carcinogenic to humans" requires validation, not speculation.
Environmental health perspectives 2003;111(4):A203-4.
2002: Ronald L Melnick
Carcinogenicity and mechanistic insights on the behavior of epoxides and epoxide-forming chemicals.
Annals of the New York Academy of Sciences 2002;982():177-89.
2002: Michael C Kohn; Ronald L Melnick
Biochemical origins of the non-monotonic receptor-mediated dose-response.
Journal of molecular endocrinology 2002;29(1):113-23.
2002: Ronald L Melnick
The IARC evaluation of di(2-ethylhexyl)phthalate (DEHP): a flawed decision based on an untested hypothesis.
International journal of occupational and environmental health 2002;8(3):284-6.
2002: Olav Axelson; Barry Castleman; Samuel Epstein; Giuliano Franco; Fernanda Giannasi; Philippe Grandjean; Morris Greenberg; Kim Hooper; James Huff; Michael Jacobson; T K Joshi; G K Kulkarni; Joseph LaDou; Maria Mazaheri; Yared Mekonnen; Ronald L Melnick; Dario Mirabelli; Roderico Ofrin; Timo Partanen; Friedrich Pott; Jennifer Beth Sass; Colin L Soskolne; Maria Lurenda Suplido; Benedetto Terracini; Lorenzo Tomatis; Gyorgy Ungvary; Andrew Watterson; Catharina Ineke Wesseling; Annalee Yassi
Re: Implementation of WHO Guidelines on Disclosure of Interest by members of WHO Expert Panels.
International journal of occupational and environmental health 2002;8(3):271-3.
2002: Michael C Kohn; Ronald L Melnick; Frank Ye; Christopher Portier
Pharmacokinetics of sodium nitrite-induced methemoglobinemia in the rat.
Drug metabolism and disposition: the biological fate of chemicals 2002;30(6):676-83.
2002: Ronald L Melnick; George W Lucier; Mary Wolfe; Roxanne Hall; George Stancel; Gail S Prins; Michael Gallo; Kenneth R Reuhl; Shuk-Mei Ho; Terry R Brown; John Moore; Julian Leakey; Joseph Haseman; Michael Kohn
Summary of the National Toxicology Program's report of the endocrine disruptors low-dose peer review.
Environmental health perspectives 2002;110(4):427-31.
2001: B A Willems; Ronald L Melnick; Michael C Kohn; Christopher Portier
A physiologically based pharmacokinetic model for inhalation and intravenous administration of naphthalene in rats and mice.
Toxicology and applied pharmacology 2001;176(2):81-91.
2001: Joseph Haseman; Ronald L Melnick; Lorenzo Tomatis; James Huff
Carcinogenesis bioassays: study duration and biological relevance.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2001;39(7):739-44.
2001: Robert C Sills; HL Hong; Gary A Boorman; Theodora R Devereux; Ronald L Melnick
Point mutations of K-ras and H-ras genes in forestomach neoplasms from control B6C3F1 mice and following exposure to 1,3-butadiene, isoprene or chloroprene for up to 2-years.
Chemico-biological interactions 2001;135-136():373-86.
2001: Michael C Kohn; Ronald L Melnick
Physiological modeling of butadiene disposition in mice and rats.
Chemico-biological interactions 2001;135-136():285-301.
2001: Ronald L Melnick; Robert C Sills
Comparative carcinogenicity of 1,3-butadiene, isoprene, and chloroprene in rats and mice.
Chemico-biological interactions 2001;135-136():27-42.
2001: Ronald L Melnick
Is peroxisome proliferation an obligatory precursor step in the carcinogenicity of di(2-ethylhexyl)phthalate (DEHP)?
Environmental health perspectives 2001;109(5):437-42.
2001: Lorenzo Tomatis; Ronald L Melnick; Joseph Haseman; J Carl Barrett; James Huff
Alleged misconceptions' distort perceptions of environmental cancer risks.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2001;15(1):195-203.
2000: Michael C Kohn; Ronald L Melnick
The privileged access model of 1,3-butadiene disposition.
Environmental health perspectives 2000;108 Suppl 5():911-7.
2000: Hue-Hua L Hong; Theodora R Devereux; Ronald L Melnick; Cindy R Moomaw; Gary A Boorman; Robert C Sills
Mutations of ras protooncogenes and p53 tumor suppressor gene in cardiac hemangiosarcomas from B6C3F1 mice exposed to 1,3-butadiene for 2 years.
Toxicologic pathology 2000;28(4):529-34.
2000: Ronald L Melnick; Michael C Kohn
Dose-response analyses of experimental cancer data.
Drug metabolism reviews 2000;32(2):193-209.
1999: Robert C Sills; James R Hailey; J Neal; Gary A Boorman; Joseph K Haseman; Ronald L Melnick
Examination of low-incidence brain tumor responses in F344 rats following chemical exposures in National Toxicology Program carcinogenicity studies.
Toxicologic pathology 1999;27(5):589-99.
1999: Michael C Kohn; Ronald L Melnick
A physiological model for ligand-induced accumulation of alpha 2u globulin in male rat kidney: roles of protein synthesis and lysosomal degradation in the renal dosimetry of 2,4,4-trimethyl-2-pentanol.
Toxicology 1999;136(2-3):89-105.
1999: Ronald L Melnick
Introduction--workshop on characterizing the effects of endocrine disruptors on human health at environmental exposure levels.
Environmental health perspectives 1999;107 Suppl 4():603-4.
1999: Ronald L Melnick; Robert C Sills; Christopher Portier; Joseph H Roycroft; Billy J Chou; Sondra L Grumbein; Rodney A Miller
Multiple organ carcinogenicity of inhaled chloroprene (2-chloro-1,3-butadiene) in F344/N rats and B6C3F1 mice and comparison of dose-response with 1,3-butadiene in mice.
Carcinogenesis 1999;20(5):867-78.
1999: Robert C Sills; HL Hong; Ronald L Melnick; Gary A Boorman; Theodora R Devereux
High frequency of codon 61 K-ras A-->T transversions in lung and Harderian gland neoplasms of B6C3F1 mice exposed to chloroprene (2-chloro-1,3-butadiene) for 2 years, and comparisons with the structurally related chemicals isoprene and 1,3-butadiene.
Carcinogenesis 1999;20(4):657-62.
1999: Ronald L Melnick; Michael C Kohn
Possible mechanisms of induction of renal tubule cell neoplasms in rats associated with alpha 2u-globulin: role of protein accumulation versus ligand delivery to the kidney.
IARC scientific publications 1999;(147):119-37.
1998: L W Reiter; C DeRosa; Robert Kavlock; G Lucier; M J Mac; J Melillo; Ronald L Melnick; T Sinks; B T Walton
The U.S. federal framework for research on endocrine disruptors and an analysis of research programs supported during fiscal year 1996.
Environmental health perspectives 1998;106(3):105-13.
1998: Ronald L Melnick; Michael C Kohn; June K Dunnick; J Leininger
Regenerative hyperplasia is not required for liver tumor induction in female B6C3F1 mice exposed to trihalomethanes.
Toxicology and applied pharmacology 1998;148(1):137-47.
1997: Ronald L Melnick; Michael C Kohn; James Huff
Weight of evidence versus weight of speculation to evaluate the alpha2u-globulin hypothesis.
Environmental health perspectives 1997;105(9):904-6.
1997: Ronald L Melnick; G A Boorman; V Dellarco
Water chlorination, 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone (MX), and potential cancer risk.
Journal of the National Cancer Institute 1997;89(12):832-3.
1997: HL Hong; Theodora R Devereux; Ronald L Melnick; S R Eldridge; A Greenwell; Joseph Haseman; Gary A Boorman; Robert C Sills
Both K-ras and H-ras protooncogene mutations are associated with Harderian gland tumorigenesis in B6C3F1 mice exposed to isoprene for 26 weeks.
Carcinogenesis 1997;18(4):783-9.
1996: Ronald L Melnick; Robert C Sills; Joseph H Roycroft; Billy J Chou; H A Ragan; Rodney A Miller
Inhalation toxicity and carcinogenicity of isoprene in rats and mice: comparisons with 1,3-butadiene.
Toxicology 1996;113(1-3):247-52.
1996: Michael C Kohn; Ronald L Melnick
Effects of the structure of a toxicokinetic model of butadiene inhalation exposure on computed production of carcinogenic intermediates.
Toxicology 1996;113(1-3):31-9.
1996: Ronald L Melnick; Michael R Elwell; Joseph H Roycroft; Billy J Chou; H A Ragan; Rodney A Miller
Toxicity of inhaled chloroprene (2-chloro-1,3-butadiene) in F344 rats and B6C3F(1) mice.
Toxicology 1996;108(1-2):79-91.
1996: Ronald L Melnick; Michael C Kohn; Christopher Portier
Implications for risk assessment of suggested nongenotoxic mechanisms of chemical carcinogenesis.
Environmental health perspectives 1996;104 Suppl 1():123-34.
1995: Ronald L Melnick; Michael C Kohn
Mechanistic data indicate that 1,3-butadiene is a human carcinogen.
Carcinogenesis 1995;16(2):157-63.
1994: Ronald L Melnick; Robert C Sills; Joseph H Roycroft; Billy J Chou; H A Ragan; Rodney A Miller
Isoprene, an endogenous hydrocarbon and industrial chemical, induces multiple organ neoplasia in rodents after 26 weeks of inhalation exposure.
Cancer research 1994;54(20):5333-9.
1994: K E Tomaszewski; Ronald L Melnick
In vitro evidence for involvement of CoA thioesters in peroxisome proliferation and hypolipidaemia.
Biochimica et biophysica acta 1994;1220(2):118-24.
1993: Ronald L Melnick; James Huff; J Carl Barrett; Robert R Maronpot; George W Lucier; Christopher Portier
Cell proliferation and chemical carcinogenesis: symposium overview.
Environmental health perspectives 1993;101 Suppl 5():3-7.
1993: Ronald L Melnick
Critique does not validate assumptions in the model on alpha 2u-globulin and renal carcinogenesis.
Regulatory toxicology and pharmacology : RTP 1993;18(2):365-8.
1993: June K Dunnick; Ronald L Melnick
Assessment of the carcinogenic potential of chlorinated water: experimental studies of chlorine, chloramine, and trihalomethanes.
Journal of the National Cancer Institute 1993;85(10):817-22.
1993: Ronald L Melnick; James Huff
Liver carcinogenesis is not a predicted outcome of chemically induced hepatocyte proliferation.
Toxicology and industrial health 1993;9(3):415-38.
1993: Michael C Kohn; Ronald L Melnick
Species differences in the production and clearance of 1,3-butadiene metabolites: a mechanistic model indicates predominantly physiological, not biochemical, control.
Carcinogenesis 1993;14(4):619-28.
1993: Ronald L Melnick; C C Shackelford; James Huff
Carcinogenicity of 1,3-butadiene.
Environmental health perspectives 1993;100():227-36.
1993: Ronald L Melnick; J E Huff
1,3-Butadiene induces cancer in experimental animals at all concentrations from 6.25 to 8000 parts per million.
IARC scientific publications 1993;(127):309-22.
1992: Ronald L Melnick
An alternative hypothesis on the role of chemically induced protein droplet (alpha 2u-globulin) nephropathy in renal carcinogenesis.
Regulatory toxicology and pharmacology : RTP 1992;16(2):111-25.
1992: Ronald L Melnick; James Huff
1,3-Butadiene: toxicity and carcinogenicity in laboratory animals and in humans.
Reviews of environmental contamination and toxicology 1992;124():111-44.
1990: K E Tomaszewski; S W Heindel; W L Jenkins; Ronald L Melnick
Induction of peroxisomal acyl CoA oxidase activity and lipid peroxidation in primary rat hepatocyte cultures.
Toxicology 1990;65(1-2):49-60.
1990: Ronald L Melnick; James Huff; Billy J Chou; Rodney A Miller
Carcinogenicity of 1,3-butadiene in C57BL/6 x C3H F1 mice at low exposure concentrations.
Cancer research 1990;50(20):6592-9.
1990: Ronald L Melnick; Joseph H Roycroft; Billy J Chou; H A Ragan; Rodney A Miller
Inhalation toxicology of isoprene in F344 rats and B6C3F1 mice following two-week exposures.
Environmental health perspectives 1990;86():93-8.
1990: Ronald L Melnick; J E Huff; Joseph H Roycroft; Billy J Chou; Rodney A Miller
Inhalation toxicology and carcinogenicity of 1,3-butadiene in B6C3F1 mice following 65 weeks of exposure.
Environmental health perspectives 1990;86():27-36.
1990: J Kralovánszky; F Harrington; A Greenwell; Ronald L Melnick
Isolation of viable intestinal epithelial cells and their use for in vitro toxicity studies.
In vivo (Athens, Greece) 1990;4(3):201-4.
1989: J Kralovánszky; W L Jenkins; A Greenwell; Ronald L Melnick
Metabolic processes in isolated rat small intestine villus cells: effects of cis-diamminedichloroplatinum (II).
Research communications in chemical pathology and pharmacology 1989;64(2):299-316.
1988: K E Tomaszewski; Charles Montgomery; Ronald L Melnick
Modulation of 2,3,7,8-tetrachlorodibenzo-p-dioxin toxicity in F344 rats by di(2-ethylhexyl)phthalate.
Chemico-biological interactions 1988;65(3):205-22.
1988: Ronald L Melnick; J E Huff; J K Haseman; E E McConnell
Chronic toxicity results and ongoing studies of 1,3-butadiene by the National Toxicology Program.
Annals of the New York Academy of Sciences 1988;534():648-62.
1987: A Greenwell; K E Tomaszewski; Ronald L Melnick
A biochemical basis for 1,2-dibromo-3-chloropropane-induced male infertility: inhibition of sperm mitochondrial electron transport activity.
Toxicology and applied pharmacology 1987;91(2):274-80.
1987: K E Tomaszewski; M C Derks; Ronald L Melnick
Acyl CoA oxidase is the most suitable marker for hepatic peroxisomal changes caused by treatment of F344 rats with di(2-ethylhexyl)phthalate.
Toxicology letters 1987;37(3):203-12.
1987: Ronald L Melnick; R E Morrissey; K E Tomaszewski
Studies by the National Toxicology Program on di(2-ethylhexyl)phthalate.
Toxicology and industrial health 1987;3(2):99-118.
1987: Ronald L Melnick; C W Jameson; TJ Goehl; G O Kuhn
Application of microencapsulation for toxicology studies. I. Principles and stabilization of trichloroethylene in gelatin-sorbitol microcapsules.
Fundamental and applied toxicology : official journal of the Society of Toxicology 1987;8(4):425-31.
1987: Ronald L Melnick; C W Jameson; TJ Goehl; Robert R Maronpot; B J Collins; A Greenwell; F W Harrington; R E Wilson; K E Tomaszewski; D K Agarwal
Application of microencapsulation for toxicology studies. II. Toxicity of microencapsulated trichloroethylene in Fischer 344 rats.
Fundamental and applied toxicology : official journal of the Society of Toxicology 1987;8(4):432-42.
1986: K E Tomaszewski; D K Agarwal; Ronald L Melnick
In vitro steady-state levels of hydrogen peroxide after exposure of male F344 rats and female B6C3F1 mice to hepatic peroxisome proliferators.
Carcinogenesis 1986;7(11):1871-6.