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Sylvain Meloche
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Chemicals & Drugs
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Network (preview)
13
Coulombe, Philippe
9
Rodier, Geneviève
9
Servant, Marc
9
Saba-El-Leil, Marc
6
Voisin, Laure
6
Giasson, Edith
5
Turgeon, Benjamin
5
Gopalbhai, Kailesh
5
Pelletier, Stephane
4
Whiteway, Malcolm
4
Ong, Huy
4
McNicoll, Normand
4
De Léan, André
3
Julien, Catherine
3
Makris, Constantin
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All Publications
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2009: Klinger Sonia; Turgeon Benjamin; Lévesque Kim; Wood Geoffrey A; Aagaard-Tillery Kjersti M; Meloche Sylvain
Loss of Erk3 function in mice leads to intrauterine growth restriction, pulmonary immaturity, and neonatal lethality.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(39):16710-5.
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2009: Coulombe Philippe; Rodier Geneviève; Meloche Sylvain
[Cdc14B/Skp2/p27 : a novel cancer axis of evil?]
Médecine sciences : M/S 2009;25(8-9):673-5.
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2009: White Michel; Ross Heather; Levesque Sylvie; Whittom Lucette; Pelletier Guy B; Racine Normand; Meloche Sylvain; Voisin Laure
Effects of angiotensin-converting enzyme inhibitor versus valsartan on cellular signaling events in heart transplant.
The Annals of pharmacotherapy 2009;43(5):831-9.
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2009: Granados Diana P; Tanguay Pierre-Luc; Hardy Marie-Pierre; Caron Etienne; de Verteuil Danielle; Meloche Sylvain; Perreault Claude
ER stress affects processing of MHC class I-associated peptides.
BMC immunology 2009;10():10.
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2008: Déléris Paul; Rousseau Justine; Coulombe Philippe; Rodier Geneviève; Tanguay Pierre-Luc; Meloche Sylvain
Activation loop phosphorylation of the atypical MAP kinases ERK3 and ERK4 is required for binding, activation and cytoplasmic relocalization of MK5.
Journal of cellular physiology 2008;217(3):778-88.
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2008: Clément Jean-François; Meloche Sylvain; Servant Marc J
The IKK-related kinases: from innate immunity to oncogenesis.
Cell research 2008;18(9):889-99.
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2008: Culjkovic Biljana; Tan Keith; Orolicki Slobodanka; Amri Abdellatif; Meloche Sylvain; Borden Katherine L B
The eIF4E RNA regulon promotes the Akt signaling pathway.
The Journal of cell biology 2008;181(1):51-63.
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2008: Clément Jean-François; Bibeau-Poirier Annie; Gravel Simon-Pierre; Grandvaux Nathalie; Bonneil Eric; Thibault Pierre; Meloche Sylvain; Servant Marc J
Phosphorylation of IRF-3 on Ser 339 generates a hyperactive form of IRF-3 through regulation of dimerization and CBP association.
Journal of virology 2008;82(8):3984-96.
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2008: Rodier Geneviève; Coulombe Philippe; Tanguay Pierre-Luc; Boutonnet Christel; Meloche Sylvain
Phosphorylation of Skp2 regulated by CDK2 and Cdc14B protects it from degradation by APC(Cdh1) in G1 phase.
The EMBO journal 2008;27(4):679-91.
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2008: Voisin Laure; Julien Catherine; Duhamel Stéphanie; Gopalbhai Kailesh; Claveau Isabelle; Saba-El-Leil Marc K; Rodrigue-Gervais Ian Gaël; Gaboury Louis; Lamarre Daniel; Basik Mark; Meloche Sylvain
Activation of MEK1 or MEK2 isoform is sufficient to fully transform intestinal epithelial cells and induce the formation of metastatic tumors.
BMC cancer 2008;8():337.
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2007: Purcell Nicole H; Wilkins Benjamin J; York Allen; Saba-El-Leil Marc K; Meloche Sylvain; Robbins Jeffrey; Molkentin Jeffery D
Genetic inhibition of cardiac ERK1/2 promotes stress-induced apoptosis and heart failure but has no effect on hypertrophy in vivo.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(35):14074-9.
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2007: Kunath Tilo; Saba-El-Leil Marc K; Almousailleakh Marwa; Wray Jason; Meloche Sylvain; Smith Austin
FGF stimulation of the Erk1/2 signalling cascade triggers transition of pluripotent embryonic stem cells from self-renewal to lineage commitment.
Development (Cambridge, England) 2007;134(16):2895-902.
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2007: Coulombe Phillipe; Meloche Sylvain
Atypical mitogen-activated protein kinases: structure, regulation and functions.
Biochimica et biophysica acta 2007;1773(8):1376-87.
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2007: Cellot Sonia; Krosl Jana; Chagraoui Jalila; Meloche Sylvain; Humphries R Keith; Sauvageau Guy
Sustained in vitro trigger of self-renewal divisions in Hoxb4hiPbx1(10) hematopoietic stem cells.
Experimental hematology 2007;35(5):802-16.
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2007: Meloche S; Pouysségur J
The ERK1/2 mitogen-activated protein kinase pathway as a master regulator of the G1- to S-phase transition.
Oncogene 2007;26(22):3227-39.
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2006: Aberg Espen; Perander Maria; Johansen Bjarne; Julien Catherine; Meloche Sylvain; Keyse Stephen M; Seternes Ole-Morten
Regulation of MAPK-activated protein kinase 5 activity and subcellular localization by the atypical MAPK ERK4/MAPK4.
The Journal of biological chemistry 2006;281(46):35499-510.
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2006: Bibeau-Poirier Annie; Gravel Simon-Pierre; Clément Jean-François; Rolland Sébastien; Rodier Geneviève; Coulombe Philippe; Hiscott John; Grandvaux Nathalie; Meloche Sylvain; Servant Marc J
Involvement of the IkappaB kinase (IKK)-related kinases tank-binding kinase 1/IKKi and cullin-based ubiquitin ligases in IFN regulatory factor-3 degradation.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(8):5059-67.
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2006: Chagraoui Jalila; Niessen Sherry L; Lessard Julie; Girard Simon; Coulombe Philippe; Sauvageau Martin; Meloche Sylvain; Sauvageau Guy
E4F1: a novel candidate factor for mediating BMI1 function in primitive hematopoietic cells.
Genes & development 2006;20(15):2110-20.
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2005: Martin Nicole L; Saba-El-Leil Marc K; Sadekova Svetlana; Meloche Sylvain; Sauvageau Guy
EN2 is a candidate oncogene in human breast cancer.
Oncogene 2005;24(46):6890-901.
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2005: Pelletier Stéphane; Julien Catherine; Popoff Michel R; Lamarche-Vane Nathalie; Meloche Sylvain
Cyclic AMP induces morphological changes of vascular smooth muscle cells by inhibiting a Rac-dependent signaling pathway.
Journal of cellular physiology 2005;204(2):412-22.
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2005: Rodier Geneviève; Makris Constantin; Coulombe Philippe; Scime Anthony; Nakayama Keiko; Nakayama Keiichi I; Meloche Sylvain
p107 inhibits G1 to S phase progression by down-regulating expression of the F-box protein Skp2.
The Journal of cell biology 2005;168(1):55-66.
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2004: Seternes Ole-Morten; Mikalsen Theresa; Johansen Bjarne; Michaelsen Espen; Armstrong Chris G; Morrice Nick A; Turgeon Benjamin; Meloche Sylvain; Moens Ugo; Keyse Stephen M
Activation of MK5/PRAK by the atypical MAP kinase ERK3 defines a novel signal transduction pathway.
The EMBO journal 2004;23(24):4780-91.
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2004: Coulombe Philippe; Rodier Geneviève; Bonneil Eric; Thibault Pierre; Meloche Sylvain
N-Terminal ubiquitination of extracellular signal-regulated kinase 3 and p21 directs their degradation by the proteasome.
Molecular and cellular biology 2004;24(14):6140-50.
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2004: Zhang Donglei; Bar-Eli Menashe; Meloche Sylvain; Brodt Pnina
Dual regulation of MMP-2 expression by the type 1 insulin-like growth factor receptor: the phosphatidylinositol 3-kinase/Akt and Raf/ERK pathways transmit opposing signals.
The Journal of biological chemistry 2004;279(19):19683-90.
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2004: Lips Daniel J; Bueno Orlando F; Wilkins Benjamin J; Purcell Nicole H; Kaiser Robert A; Lorenz John N; Voisin Laure; Saba-El-Leil Marc K; Meloche Sylvain; Pouysségur Jacques; Pagès Gilles; De Windt Leon J; Doevendans Pieter A; Molkentin Jeffery D
MEK1-ERK2 signaling pathway protects myocardium from ischemic injury in vivo.
Circulation 2004;109(16):1938-41.
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2004: Meloche Sylvain; Vella Francis D J; Voisin Laure; Ang Siew-Lan; Saba-El-Leil Marc
Erk2 signaling and early embryo stem cell self-renewal.
Cell cycle (Georgetown, Tex.) 2004;3(3):241-3.
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2003: Wu Cunle; Arcand Mathieu; Jansen Gregor; Zhong Mei; Iouk Tatiana; Thomas David Y; Meloche Sylvain; Whiteway Malcolm
Phosphorylation of the MAPKKK regulator Ste50p in Saccharomyces cerevisiae: a casein kinase I phosphorylation site is required for proper mating function.
Eukaryotic cell 2003;2(5):949-61.
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2003: Saba-El-Leil Marc K; Vella Francis D J; Vernay Bertrand; Voisin Laure; Chen Lan; Labrecque Nathalie; Ang Siew-Lan; Meloche Sylvain
An essential function of the mitogen-activated protein kinase Erk2 in mouse trophoblast development.
EMBO reports 2003;4(10):964-8.
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2003: Julien Catherine; Coulombe Philippe; Meloche Sylvain
Nuclear export of ERK3 by a CRM1-dependent mechanism regulates its inhibitory action on cell cycle progression.
The Journal of biological chemistry 2003;278(43):42615-24.
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2003: Coulombe Philippe; Rodier Geneviève; Pelletier Stéphane; Pellerin Johanne; Meloche Sylvain
Rapid turnover of extracellular signal-regulated kinase 3 by the ubiquitin-proteasome pathway defines a novel paradigm of mitogen-activated protein kinase regulation during cellular differentiation.
Molecular and cellular biology 2003;23(13):4542-58.
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2003: Gingras Bruno; Rodier Geneviève; Giasson Edith; Coulombe Philippe; Chassagne Catherine; Meloche Sylvain
Expression of angiotensin type II receptor downregulates Cdk4 synthesis and inhibits cell-cycle progression.
Oncogene 2003;22(17):2633-42.
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2003: Gopalbhai Kailesh; Jansen Gregor; Beauregard Geneviève; Whiteway Malcolm; Dumas France; Wu Cunle; Meloche Sylvain
Negative regulation of MAPKK by phosphorylation of a conserved serine residue equivalent to Ser212 of MEK1.
The Journal of biological chemistry 2003;278(10):8118-25.
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2003: Gennaro Giuseppa; Ménard Catherine; Giasson Edith; Michaud Sophie-Elise; Palasis Maria; Meloche Sylvain; Rivard Alain
Role of p44/p42 MAP kinase in the age-dependent increase in vascular smooth muscle cell proliferation and neointimal formation.
Arteriosclerosis, thrombosis, and vascular biology 2003;23(2):204-10.
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2003: Pelletier Stéphane; Duhamel François; Coulombe Philippe; Popoff Michel R; Meloche Sylvain
Rho family GTPases are required for activation of Jak/STAT signaling by G protein-coupled receptors.
Molecular and cellular biology 2003;23(4):1316-33.
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2002: Turgeon Benjamin; Lang B Franz; Meloche Sylvain
The protein kinase ERK3 is encoded by a single functional gene: genomic analysis of the ERK3 gene family.
Genomics 2002;80(6):673-80.
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2002: Coulombe Philippe; Meloche Sylvain
Dual-tag prokaryotic vectors for enhanced expression of full-length recombinant proteins.
Analytical biochemistry 2002;310(2):219-22.
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2002: Makris Constantin; Voisin Laure; Giasson Edith; Tudan Christopher; Kaplan David R; Meloche Sylvain
The Rb-family protein p107 inhibits translation by a PDK1-dependent mechanism.
Oncogene 2002;21(51):7891-6.
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2002: Voisin Laure; Foisy Sylvain; Giasson Edith; Lambert Chantal; Moreau Pierre; Meloche Sylvain
EGF receptor transactivation is obligatory for protein synthesis stimulation by G protein-coupled receptors.
American journal of physiology. Cell physiology 2002;283(2):C446-55.
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2002: Chassagne Catherine; Adamy Christophe; Ratajczak Philippe; Gingras Bruno; Teiger Emmanuel; Planus Emmanuelle; Oliviero Patricia; Rappaport Lydie; Samuel Jane-Lise; Meloche Sylvain
Angiotensin II AT(2) receptor inhibits smooth muscle cell migration via fibronectin cell production and binding.
American journal of physiology. Cell physiology 2002;282(4):C654-64.
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2001: Rodier G; Montagnoli A; Di Marcotullio L; Coulombe P; Draetta G F; Pagano M; Meloche S
p27 cytoplasmic localization is regulated by phosphorylation on Ser10 and is not a prerequisite for its proteolysis.
The EMBO journal 2001;20(23):6672-82.
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2001: Charron F; Tsimiklis G; Arcand M; Robitaille L; Liang Q; Molkentin J D; Meloche S; Nemer M
Tissue-specific GATA factors are transcriptional effectors of the small GTPase RhoA.
Genes & development 2001;15(20):2702-19.
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2001: Rouleau J L; Kapuku G; Pelletier S; Gosselin H; Adam A; Gagnon C; Lambert C; Meloche S
Cardioprotective effects of ramipril and losartan in right ventricular pressure overload in the rabbit: importance of kinins and influence on angiotensin II type 1 receptor signaling pathway.
Circulation 2001;104(8):939-44.
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2000: Meloche S; Pelletier S; Servant M J
Functional cross-talk between the cyclic AMP and Jak/STAT signaling pathways in vascular smooth muscle cells.
Molecular and cellular biochemistry 2000;212(1-2):99-109.
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2000: Meloche S; Landry J; Huot J; Houle F; Marceau F; Giasson E
p38 MAP kinase pathway regulates angiotensin II-induced contraction of rat vascular smooth muscle.
American journal of physiology. Heart and circulatory physiology 2000;279(2):H741-51.
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2000: Yen L; You X L; Al Moustafa A E; Batist G; Hynes N E; Mader S; Meloche S; Alaoui-Jamali M A
Heregulin selectively upregulates vascular endothelial growth factor secretion in cancer cells and stimulates angiogenesis.
Oncogene 2000;19(31):3460-9.
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2000: Servant M J; Coulombe P; Turgeon B; Meloche S
Differential regulation of p27(Kip1) expression by mitogenic and hypertrophic factors: Involvement of transcriptional and posttranscriptional mechanisms.
The Journal of cell biology 2000;148(3):543-56.
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2000: Turgeon B; Saba-El-Leil M K; Meloche S
Cloning and characterization of mouse extracellular-signal-regulated protein kinase 3 as a unique gene product of 100 kDa.
The Biochemical journal 2000;346 Pt 1():169-75.
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2000: Meloche S; Gopalbhai K; Beatty B G; Scherer S W; Pellerin J
Chromosome mapping of the human genes encoding the MAP kinase kinase MEK1 (MAP2K1) to 15q21 and MEK2 (MAP2K2) to 7q32.
Cytogenetics and cell genetics 2000;88(3-4):249-52.
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1999: Bastien N R; Servant M J; Gutkowska J; Meloche S; Lambert C
Downregulation of cardiac AT1-receptor expression and angiotensin II concentrations after long-term blockade of the renin-angiotensin system in cardiomyopathic hamsters.
Journal of cardiovascular pharmacology 1999;34(3):402-6.
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1999: Voisin L; Larose L; Meloche S
Angiotensin II stimulates serine phosphorylation of the adaptor protein Nck: physical association with the serine/threonine kinases Pak1 and casein kinase I.
The Biochemical journal 1999;341 ( Pt 1)():217-23.
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1998: Csank C; Schröppel K; Leberer E; Harcus D; Mohamed O; Meloche S; Thomas D Y; Whiteway M
Roles of the Candida albicans mitogen-activated protein kinase homolog, Cek1p, in hyphal development and systemic candidiasis.
Infection and immunity 1998;66(6):2713-21.
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1998: Gopalbhai K; Meloche S
Repression of mitogen-activated protein kinases ERK1/ERK2 activity by a protein tyrosine phosphatase in rat fibroblasts transformed by upstream oncoproteins.
Journal of cellular physiology 1998;174(1):35-47.
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1997: Csank C; Makris C; Meloche S; Schröppel K; Röllinghoff M; Dignard D; Thomas D Y; Whiteway M
Derepressed hyphal growth and reduced virulence in a VH1 family-related protein phosphatase mutant of the human pathogen Candida albicans.
Molecular biology of the cell 1997;8(12):2539-51.
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1997: Giasson E; Servant M J; Meloche S
Cyclic AMP-mediated inhibition of angiotensin II-induced protein synthesis is associated with suppression of tyrosine phosphorylation signaling in vascular smooth muscle cells.
The Journal of biological chemistry 1997;272(43):26879-86.
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1997: Scimeca J C; Servant M J; Dyer J O; Meloche S
Essential role of calcium in the regulation of MAP kinase phosphatase-1 expression.
Oncogene 1997;15(6):717-25.
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1997: Benzeroual K; van de Werve G; Meloche S; Mathé L; Romanelli A; Haddad P
Insulin induces Ca2+ influx into isolated rat hepatocyte couplets.
The American journal of physiology 1997;272(6 Pt 1):G1425-32.
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1997: Saba-el-Leil M K; Malo D; Meloche S
Chromosomal localization of the mouse genes encoding the ERK1 and ERK2 isoforms of MAP kinases.
Mammalian genome : official journal of the International Mammalian Genome Society 1997;8(2):141-2.
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1997: Fleurent M; Gingras A C; Sonenberg N; Meloche S
Angiotensin II stimulates phosphorylation of the translational repressor 4E-binding protein 1 by a mitogen-activated protein kinase-independent mechanism.
The Journal of biological chemistry 1997;272(7):4006-12.
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1996: Meloche S; Beatty B G; Pellerin J
Primary structure, expression and chromosomal locus of a human homolog of rat ERK3.
Oncogene 1996;13(7):1575-9.
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1996: Rajotte D; Sadowski H B; Haman A; Gopalbhai K; Meloche S; Liu L; Krystal G; Hoang T
Contribution of both STAT and SRF/TCF to c-fos promoter activation by granulocyte-macrophage colony-stimulating factor.
Blood 1996;88(8):2906-16.
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1996: Servant M J; Giasson E; Meloche S
Inhibition of growth factor-induced protein synthesis by a selective MEK inhibitor in aortic smooth muscle cells.
The Journal of biological chemistry 1996;271(27):16047-52.
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1996: Lin R; Beauparlant P; Makris C; Meloche S; Hiscott J
Phosphorylation of IkappaBalpha in the C-terminal PEST domain by casein kinase II affects intrinsic protein stability.
Molecular and cellular biology 1996;16(4):1401-9.
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1995: Lambert C; Massillon Y; Meloche S
Upregulation of cardiac angiotensin II AT1 receptors in congenital cardiomyopathic hamsters.
Circulation research 1995;77(5):1001-7.
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1995: Leduc I; Haddad P; Giasson E; Meloche S
Involvement of a tyrosine kinase pathway in the growth-promoting effects of angiotensin II on aortic smooth muscle cells.
Molecular pharmacology 1995;48(4):582-92.
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1995: Meloche S
Cell cycle reentry of mammalian fibroblasts is accompanied by the sustained activation of p44mapk and p42mapk isoforms in the G1 phase and their inactivation at the G1/S transition.
Journal of cellular physiology 1995;163(3):577-88.
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1995: Leduc I; Meloche S
Angiotensin II stimulates tyrosine phosphorylation of the focal adhesion-associated protein paxillin in aortic smooth muscle cells.
The Journal of biological chemistry 1995;270(9):4401-4.
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1995: Giasson E; Meloche S
Role of p70 S6 protein kinase in angiotensin II-induced protein synthesis in vascular smooth muscle cells.
The Journal of biological chemistry 1995;270(10):5225-31.
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1995: Chassagne C; Beatty B G; Meloche S
Assignment of the human angiotensin II type 2 receptor gene (AGTR2) to chromosome Xq22-q23 by fluorescence in situ hybridization.
Genomics 1995;25(2):601-3.
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1992: Rondeau J J; McNicoll N; Lord C; Larose L; Meloche S; Gagnon J; Ong H; De Léan A
Production of polyclonal antibody to the bovine adrenal atrial natriuretic factor-R1 receptor.
Journal of receptor research 1992;12(4):485-505.
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1990: Rondeau J J; McNicoll N; Escher E; Meloche S; Ong H; De Léan A
Hydrodynamic properties of the angiotensin II receptor from bovine adrenal zona glomerulosa.
The Biochemical journal 1990;268(2):443-8.
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1989: Liu B; Meloche S; McNicoll N; Lord C; De Léan A
Topographical characterization of the domain structure of the bovine adrenal atrial natriuretic factor R1 receptor.
Biochemistry 1989;28(13):5599-605.
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1989: Féthière J; Meloche S; Nguyen T T; Ong H; De Lean A
Distinct properties of atrial natriuretic factor receptor subpopulations in epithelial and fibroblast cell lines.
Molecular pharmacology 1989;35(5):584-92.
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1988: Meloche S; McNicoll N; Liu B; Ong H; De Léan A
Atrial natriuretic factor R1 receptor from bovine adrenal zona glomerulosa: purification, characterization, and modulation by amiloride.
Biochemistry 1988;27(21):8151-8.
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