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Peter Meltzer

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Peter C Meltzer; Olga Kryatova; Duy-Phong Pham-Huu; Patrick Donovan; Aaron Janowsky
The synthesis of bivalent 2beta-carbomethoxy-3beta-(3,4-dichlorophenyl)-8-heterobicyclo[3.2.1]octanes as probes for proximal binding sites on the dopamine and serotonin transporters.
Thomas J Spencer; Joseph Biederman; Bertha K Madras; Darin D Dougherty; Ali A Bonab; Eli Livni; Peter C Meltzer; Jessica Martin; Scott Rauch; Alan J Fischman
Further evidence of dopamine transporter dysregulation in ADHD: a controlled PET imaging study using altropane.
Duy-Phong Pham-Huu; Jeffrey Deschamps; Shanghao Liu; Bertha K Madras; Peter C Meltzer
Synthesis of 8-thiabicyclo[3.2.1]octanes and their binding affinity for the dopamine and serotonin transporters.

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All Publications

2008: Peter C Meltzer; Olga Kryatova; Duy-Phong Pham-Huu; Patrick Donovan; Aaron Janowsky
The synthesis of bivalent 2beta-carbomethoxy-3beta-(3,4-dichlorophenyl)-8-heterobicyclo[3.2.1]octanes as probes for proximal binding sites on the dopamine and serotonin transporters.
Bioorganic & medicinal chemistry 2008;16(4):1832-41.
2007: Thomas J Spencer; Joseph Biederman; Bertha K Madras; Darin D Dougherty; Ali A Bonab; Eli Livni; Peter C Meltzer; Jessica Martin; Scott Rauch; Alan J Fischman
Further evidence of dopamine transporter dysregulation in ADHD: a controlled PET imaging study using altropane.
Biological psychiatry 2007;62(9):1059-61.
2007: Duy-Phong Pham-Huu; Jeffrey Deschamps; Shanghao Liu; Bertha K Madras; Peter C Meltzer
Synthesis of 8-thiabicyclo[3.2.1]octanes and their binding affinity for the dopamine and serotonin transporters.
Bioorganic & medicinal chemistry 2007;15(2):1067-82.
2006: Bertha K Madras; Michele A Fahey; Martin Goulet; Zhicheng Lin; Jacob Bendor; Claudia Goodrich; Peter C Meltzer; David R Elmaleh; Eli Livni; Ali A Bonab; Alan J Fischman
Dopamine transporter (DAT) inhibitors alleviate specific parkinsonian deficits in monkeys: association with DAT occupancy in vivo.
The Journal of pharmacology and experimental therapeutics 2006;319(2):570-85.
2006: Peter C Meltzer; David Butler; Jeffrey Deschamps; Bertha K Madras
1-(4-Methylphenyl)-2-pyrrolidin-1-yl-pentan-1-one (Pyrovalerone) analogues: a promising class of monoamine uptake inhibitors.
Journal of medicinal chemistry 2006;49(4):1420-32.
2004: Peter C Meltzer; Duy-Phong Pham-Huu; Bertha K Madras
Synthesis of 8-thiabicyclo[3.2.1]oct-2-enes and their binding affinity for the dopamine and serotonin transporters.
Bioorganic & medicinal chemistry letters 2004;14(24):6007-10.
2003: Peter C Meltzer; Mark McPhee; Bertha K Madras
Synthesis and biological activity of 2-carbomethoxy-3-catechol-8-azabicyclo[3.2.1]octanes.
Bioorganic & medicinal chemistry letters 2003;13(22):4133-7.
2003: Bertha K Madras; Michele A Fahey; Gregory M Miller; Richard De La Garza; Martin Goulet; Roger D Spealman; Peter C Meltzer; Susan R George; Brian F O'Dowd; Ali A Bonab; Eli Livni; Alan J Fischman
Non-amine-based dopamine transporter (reuptake) inhibitors retain properties of amine-based progenitors.
European journal of pharmacology 2003;479(1-3):41-51.
2003: Peter C Meltzer; Paul Blundell; Thomas Zona; Lihua Yang; Hong Huang; Ali A Bonab; Eli Livni; Alan J Fischman; Bertha K Madras
A second-generation 99m technetium single photon emission computed tomography agent that provides in vivo images of the dopamine transporter in primate brain.
Journal of medicinal chemistry 2003;46(16):3483-96.
2003: Peter C Meltzer; Pinglang Wang; Paul Blundell; Bertha K Madras
Synthesis and evaluation of dopamine and serotonin transporter inhibition by oxacyclic and carbacyclic analogues of methylphenidate.
Journal of medicinal chemistry 2003;46(8):1538-45.
2002: Peter C Meltzer; Shanghao Liu; Heather Blanchette; Paul Blundell; Bertha K Madras
Design and synthesis of an irreversible dopamine-sparing cocaine antagonist.
Bioorganic & medicinal chemistry 2002;10(11):3583-91.
2001: Martin Goulet; Gregory M Miller; Jacob Bendor; S Liu; Peter C Meltzer; Bertha K Madras
Non-amines, drugs without an amine nitrogen, potently block serotonin transport: novel antidepressant candidates?
Synapse (New York, N.Y.) 2001;42(3):129-40.
2001: Peter C Meltzer; B Wang; Z Chen; Paul Blundell; M Jayaraman; MD Gonzalez; C George; Bertha K Madras
Synthesis of 6- and 7- hydroxy-8-azabicyclo[3.2.1]octanes and their binding affinity for the dopamine and serotonin transporters.
Journal of medicinal chemistry 2001;44(16):2619-35.
2001: Alan J Fischman; Ali A Bonab; John W Babich; Eli Livni; Nathaniel M Alpert; Peter C Meltzer; Bertha K Madras
[(11)C, (127)I] Altropane: a highly selective ligand for PET imaging of dopamine transporter sites.
Synapse (New York, N.Y.) 2001;39(4):332-42.
2000: Peter C Meltzer; Paul Blundell; YF Yong; Z Chen; C George; MD Gonzalez; Bertha K Madras
2-Carbomethoxy-3-aryl-8-bicyclo[3.2.1]octanes: potent non-nitrogen inhibitors of monoamine transporters.
Journal of medicinal chemistry 2000;43(16):2982-91.
2000: Bertha K Madras; Gregory M Miller; Peter C Meltzer; Anna-Liisa Brownell; Alan J Fischman
Molecular and regional targets of cocaine in primate brain: liberation from prosaic views.
Addiction biology 2000;5(3):351-9.
2000: Peter C Meltzer; Paul Blundell; H Huang; Shanghao Liu; YF Yong; Bertha K Madras
3-Aryl-2-carbomethoxybicyclo[3.2.1]oct-2-enes inhibit WIN 35,428 binding potently and selectively at the dopamine transporter.
Bioorganic & medicinal chemistry 2000;8(3):581-90.
1999: Richard De La Garza; Peter C Meltzer; Bertha K Madras
Non-amine dopamine transporter probe [(3)H]tropoxene distributes to dopamine-rich regions of monkey brain.
Synapse (New York, N.Y.) 1999;34(1):20-7.
1999: Peter C Meltzer; Paul Blundell; Z Chen; YF Yong; Bertha K Madras
Bicyclo[3.2.1]octanes: synthesis and inhibition of binding at the dopamine and serotonin transporters.
Bioorganic & medicinal chemistry letters 1999;9(6):857-62.
1998: Alan J Fischman; Ali A Bonab; John W Babich; E P Palmer; Nathaniel M Alpert; David R Elmaleh; Ronald J Callahan; SA Barrow; W Graham; Peter C Meltzer; Robert N Hanson; Bertha K Madras
Rapid detection of Parkinson's disease by SPECT with altropane: a selective ligand for dopamine transporters.
Synapse (New York, N.Y.) 1998;29(2):128-41.
1998: Bertha K Madras; L M Gracz; Michele A Fahey; David R Elmaleh; Peter C Meltzer; AY Liang; Edward G Stopa; John W Babich; Alan J Fischman
Altropane, a SPECT or PET imaging probe for dopamine neurons: III. Human dopamine transporter in postmortem normal and Parkinson's diseased brain.
Synapse (New York, N.Y.) 1998;29(2):116-27.
1998: Bertha K Madras; L M Gracz; Peter C Meltzer; AY Liang; David R Elmaleh; Marc J Kaufman; Alan J Fischman
Altropane, a SPECT or PET imaging probe for dopamine neurons: II. Distribution to dopamine-rich regions of primate brain.
Synapse (New York, N.Y.) 1998;29(2):105-15.
1998: Bertha K Madras; Peter C Meltzer; AY Liang; David R Elmaleh; John W Babich; Alan J Fischman
Altropane, a SPECT or PET imaging probe for dopamine neurons: I. Dopamine transporter binding in primate brain.
Synapse (New York, N.Y.) 1998;29(2):93-104.
1997: Peter C Meltzer; AY Liang; Paul Blundell; MD Gonzalez; Z Chen; C George; Bertha K Madras
2-Carbomethoxy-3-aryl-8-oxabicyclo[3.2.1]octanes: potent non-nitrogen inhibitors of monoamine transporters.
Journal of medicinal chemistry 1997;40(17):2661-73.
1997: Peter C Meltzer; Paul Blundell; Alun G Jones; Ashfaq Mahmood; BM Garada; R E Zimmerman; Alan Davison; BL Holman; Bertha K Madras
A technetium-99m SPECT imaging agent which targets the dopamine transporter in primate brain.
Journal of medicinal chemistry 1997;40(12):1835-44.
1997: Peter C Meltzer; Bertha K Madras
Imaging of dopamine transporters in humans with technetium-99m TRODAT-1.
European journal of nuclear medicine 1997;24(4):462-3.
1996: Bertha K Madras; Zdenek Pristupa; Hyman B Niznik; AY Liang; Paul Blundell; M D Gonzalez; Peter C Meltzer
Nitrogen-based drugs are not essential for blockade of monoamine transporters.
Synapse (New York, N.Y.) 1996;24(4):340-8.
1996: David R Elmaleh; Alan J Fischman; T M Shoup; C Byon; Robert N Hanson; AY Liang; Peter C Meltzer; Bertha K Madras
Preparation and biological evaluation of iodine-125-IACFT: a selective SPECT agent for imaging dopamine transporter sites.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 1996;37(7):1197-202.
1996: Anna-Liisa Brownell; David R Elmaleh; Peter C Meltzer; T M Shoup; G L Brownell; Alan J Fischman; Bertha K Madras
Cocaine congeners as PET imaging probes for dopamine terminals.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 1996;37(7):1186-92.
1996: Bertha K Madras; A G Jones; A Mahmood; R E Zimmerman; BM Garada; BL Holman; A Davison; Paul Blundell; Peter C Meltzer
Technepine: a high-affinity 99m-technetium probe to label the dopamine transporter in brain by SPECT imaging.
Synapse (New York, N.Y.) 1996;22(3):239-46.
1996: Peter C Meltzer; AY Liang; Bertha K Madras
2-Carbomethoxy-3-(diarylmethoxy)-1 alpha H, 5 alpha H-tropane analogs: synthesis and inhibition of binding at the dopamine transporter and comparison with piperazines of the GBR series.
Journal of medicinal chemistry 1996;39(2):371-9.
1994: Peter C Meltzer; AY Liang; Bertha K Madras
The discovery of an unusually selective and novel cocaine analog: difluoropine. Synthesis and inhibition of binding at cocaine recognition sites.
Journal of medicinal chemistry 1994;37(13):2001-10.
1994: Bertha K Madras; Maarten E A Reith; Peter C Meltzer; Aloke Dutta
O-526, a piperidine analog of GBR 12909, retains high affinity for the dopamine transporter in monkey caudate-putamen.
European journal of pharmacology 1994;267(2):167-73.
1994: Bertha K Madras; D R Elmaleh; Peter C Meltzer; A Y Liang; G L Brownell; A L Brownell
Positron emission tomography of cocaine binding sites on the dopamine transporter.
NIDA research monograph 1994;138():57-69.
1993: Peter C Meltzer; AY Liang; A L Brownell; David R Elmaleh; Bertha K Madras
Substituted 3-phenyltropane analogs of cocaine: synthesis, inhibition of binding at cocaine recognition sites, and positron emission tomography imaging.
Journal of medicinal chemistry 1993;36(7):855-62.