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Yves Mély

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Julien Batisse; Serena Bernacchi; Hugues de Rocquigny; Julien Godet; Valérie Goldschmidt; Santiago Xavier Guerrero; Roland Marquet; Yves Mély; Ludovic Richert; Jean-Christophe Paillart
APOBEC3G Impairs the Multimerization of the HIV-1 Vif Protein in Living Cells.
Julien Godet; Cyril Kenfack; Frédéric Przybilla; Ludovic Richert; Guy Duportail; Yves Mély
Site-selective probing of cTAR destabilization highlights the necessary plasticity of the HIV-1 nucleocapsid protein to chaperone the first strand transfer.
Anne-Sophie Rinaldi; Natacha Rochel; Annie-Paule Sibler; Mireille Baltzinger; Dominique Desplancq; Pascal Didier; Guillaume Freund; Yves Mély; Etienne Weiss
The use of fluorescent intrabodies to detect endogenous gankyrin in living cancer cells.

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2013: Julien Batisse; Serena Bernacchi; Hugues de Rocquigny; Julien Godet; Valérie Goldschmidt; Santiago Xavier Guerrero; Roland Marquet; Yves Mély; Ludovic Richert; Jean-Christophe Paillart
APOBEC3G Impairs the Multimerization of the HIV-1 Vif Protein in Living Cells.
Journal of virology 2013;87(11):6492-506.
2013: Julien Godet; Cyril Kenfack; Frédéric Przybilla; Ludovic Richert; Guy Duportail; Yves Mély
Site-selective probing of cTAR destabilization highlights the necessary plasticity of the HIV-1 nucleocapsid protein to chaperone the first strand transfer.
Nucleic acids research 2013;41(9):5036-48.
2013: Anne-Sophie Rinaldi; Natacha Rochel; Annie-Paule Sibler; Mireille Baltzinger; Dominique Desplancq; Pascal Didier; Guillaume Freund; Yves Mély; Etienne Weiss
The use of fluorescent intrabodies to detect endogenous gankyrin in living cancer cells.
Experimental cell research 2013;319(6):838-49.
2012: Aleksandr V Strizhak; Eric Guittet; Andrey S Klymchenko; Nelly Morellet; Vasyl G Pivovarenko; Viktoriia Y Postupalenko; Volodymyr V Shvadchak; Yves Mély
Two-color fluorescent l-amino acid mimic of tryptophan for probing peptide-nucleic acid complexes.
Bioconjugate chemistry 2012;23(12):2434-43.
2012: Annette Niehl; Yves Mély; Khalid Amari; Katrin Brandner; Dalya Gereige; Manfred Heinlein
Control of Tobacco mosaic virus movement protein fate by CELL-DIVISION-CYCLE protein48.
Plant physiology 2012;160(4):2093-108.
2012: Zeinab Darwich; Andrey S Klymchenko; Oleksandr A Kucherak; Ludovic Richert; Yves Mély
Detection of apoptosis through the lipid order of the outer plasma membrane leaflet.
Biochimica et biophysica acta 2012;1818(12):3048-54.
2012: Julien Godet; Nicolas Humbert; Roland Ivanyi-Nagy; Christian Boudier; Jean-Luc Darlix; Yves Mély
Comparative nucleic acid chaperone properties of the nucleocapsid protein NCp7 and Tat protein of HIV-1.
Virus research 2012;169(2):349-60.
2012: Mattia Mori; Sarah Sanglier-Cianferani; Patrizia Schult-Dietrich; Beata Szafarowicz; Francois Debaene; Ursula Dietrich; Nicolas Humbert; Yves Mély; Maurizio Botta
Use of virtual screening for discovering antiretroviral compounds interacting with the HIV-1 nucleocapsid protein.
Virus research 2012;169(2):377-87.
2012: Vanille J Greiner; Andrey S Klymchenko; Eric Larquet; Catherine Manin; Julie Bonvin; Bernard Desbat; Catherine Estèves; Frédéric Gréco; Frédéric Ronzon; Yves Mély
The structure of HBsAg particles is not modified upon their adsorption on aluminium hydroxide gel.
Vaccine 2012;30(35):5240-5.
2012: Cyril A Kenfack; Andrey S Klymchenko; Alain Burger; Guy Duportail; Yves Mély
Ab initio study of the solvent H-bonding effect on ESIPT reaction and electronic transitions of 3-hydroxychromone derivatives.
Physical chemistry chemical physics : PCCP 2012;14(25):8910-8.
2012: Dmytro Dziuba; Vincent Guérineau; Andrey S Klymchenko; Yves Mély; Viktoriia Y Postupalenko; Marie Spadafora; Rachid Benhida; Alain Burger
A universal nucleoside with strong two-band switchable fluorescence and sensitivity to the environment for investigating DNA interactions.
Journal of the American Chemical Society 2012;134(24):10209-13.
2012: Ranjan Das; Guy Duportail; Andrey Klymchenko; Ludovic Richert; Yves Mély
Sensing micelle hydration by proton-transfer dynamics of a 3-hydroxychromone dye: role of the surfactant headgroup and chain length.
Langmuir : the ACS journal of surfaces and colloids 2012;28(18):7147-59.
2012: Vasyl G Pivovarenko; Viktoriia Y Postupalenko; Volodymyr V Shvadchak; Oleksandr M Zamotaiev; Andrey S Klymchenko; Yves Mély
Quantification of local hydration at the surface of biomolecules using dual-fluorescence labels.
The journal of physical chemistry. A 2012;116(12):3103-9.
2012: Geoffray Leriche; Yves Mély; Ghyslain Budin; Zeinab Darwich; Andrey S Klymchenko; Denis WELTIN; Alain Wagner
A FRET-based probe with a chemically deactivatable quencher.
Chemical communications (Cambridge, England) 2012;48(26):3224-6.
2012: Kamal Kant Sharma; François Pénin; Jean-Luc Darlix; Hugues de Rocquigny; Jean-Pierre Lavergne; Jean-Marc Lessinger; Yves Mély
Analysis of the RNA chaperoning activity of the hepatitis C virus core protein on the conserved 3'X region of the viral genome.
Nucleic acids research 2012;40(6):2540-53.
2012: Namrata Jain; Youri Arntz; Guy Duportail; Valérie Goldschmidt; Yves Mély; Sule Oncul; Andrey S Klymchenko
Lactose-ornithine bolaamphiphiles for efficient gene delivery in vitro.
International journal of pharmaceutics 2012;423(2):392-400.
2012: Oleksandr A Kucherak; Yves Mély; Ludovic Richert; Andrey S Klymchenko
Dipolar 3-methoxychromones as bright and highly solvatochromic fluorescent dyes.
Physical chemistry chemical physics : PCCP 2012;14(7):2292-300.
2012: A L Jouonang; P Didier; Yves Mély
Identification of a thermally activated process in the Cy3 photobleaching mechanism.
Physical chemistry chemical physics : PCCP 2012;14(5):1585-8.
2012: Sergiy V Avilov; Christian Boudier; Jean-Luc Darlix; Marina Gottikh; Yves Mély
Characterization of the inhibition mechanism of HIV-1 nucleocapsid protein chaperone activities by methylated oligoribonucleotides.
Antimicrobial agents and chemotherapy 2012;56(2):1010-8.
2012: Thomas Vercruysse; Jan Balzarini; Beata Basta; François Debaene; Wim Dehaen; Nicolas Humbert; Yves Mély; Christophe Pannecouque; Sarah Sanglier-Cianférani; Dirk Daelemans
A phenyl-thiadiazolylidene-amine derivative ejects zinc from retroviral nucleocapsid zinc fingers and inactivates HIV virions.
Retrovirology 2012;9():95.
2012: Ali Bazzi; Françoise Chaminade; Hugues de Rocquigny; Philippe Fossé; Yves Mély; Brigitte RENE; Loussiné Zargarian; Olivier Mauffret
Intrinsic nucleic acid dynamics modulates HIV-1 nucleocapsid protein binding to its targets.
PloS one 2012;7(6):e38905.
2011: Cécile Guichard; Roland Ivanyi-Nagy; Daniel Marc; Yves Mély; Kamal Kant Sharma; Caroline Gabus; Jean-Luc Darlix
Analysis of nucleic acid chaperoning by the prion protein and its inhibition by oligonucleotides.
Nucleic acids research 2011;39(19):8544-58.
2011: Igor Kanevsky; Olivier Mauffret; Yves Mély; Brigitte RENE; Françoise Chaminade; Yingying Chen; Jean-Luc Darlix; Julien Godet; Philippe Fossé
Structural determinants of TAR RNA-DNA annealing in the absence and presence of HIV-1 nucleocapsid protein.
Nucleic acids research 2011;39(18):8148-62.
2011: Vanille J Greiner; Yves Mély; Volodymyr V Shvadchak; Youri Arntz; Christian Boudier; Pascal Didier; Benoît Frisch; Joëlle Fritz; Hugues de Rocquigny
Characterization of the mechanisms of HIV-1 Vpr(52-96) internalization in cells.
Biochimie 2011;93(10):1647-58.
2011: Julien Godet; Jean-Luc Darlix; Hugues de Rocquigny; Guy Duportail; Nick Ramalanjaona; Ludovic Richert; Kamal K Sharma; Yves Mély
Specific implications of the HIV-1 nucleocapsid zinc fingers in the annealing of the primer binding site complementary sequences during the obligatory plus strand transfer.
Nucleic acids research 2011;39(15):6633-45.
2011: Jean-Luc Darlix; Philippe Fossé; Julien Godet; Roland Ivanyi-Nagy; Olivier Mauffret; Yves Mély
Flexible nature and specific functions of the HIV-1 nucleocapsid protein.
Journal of molecular biology 2011;410(4):565-81.
2011: Boyan Grigorov; Yves Mély; Myriam Witvrouw; Gilles Divita; Caroline Gabus; Marina Gottikh; Audrey Agopian; Sergey Avilov; Anne Bocquin; Jean-Luc Darlix
Identification of a methylated oligoribonucleotide as a potent inhibitor of HIV-1 reverse transcription complex.
Nucleic acids research 2011;39(13):5586-96.
2011: Roman V Rodik; Andrey S Klymchenko; Namrata Jain; Stanislav I Miroshnichenko; Ludovic Richert; Vitaly I Kalchenko; Yves Mély
Virus-sized DNA nanoparticles for gene delivery based on micelles of cationic calixarenes.
Chemistry (Weinheim an der Bergstrasse, Germany) 2011;17(20):5526-38.
2011: Natacha Rochel; Fabrice Ciesielski; Julien Godet; Edelmiro Moman; Manfred Roessle; Carole Peluso-Iltis; Martine Moulin; Michael Haertlein; Phil Callow; Yves Mély; Dmitri I Svergun; Dino Moras
Common architecture of nuclear receptor heterodimers on DNA direct repeat elements with different spacings.
Nature structural & molecular biology 2011;18(5):564-70.
2011: Ali Bazzi; Loussiné Zargarian; Françoise Chaminade; Christian Boudier; Hugues de Rocquigny; Brigitte René; Yves Mély; Philippe Fossé; Olivier Mauffret
Structural insights into the cTAR DNA recognition by the HIV-1 nucleocapsid protein: role of sugar deoxyriboses in the binding polarity of NC.
Nucleic acids research 2011;39(9):3903-16.
2011: Oleksandr M Zamotaiev; Viktoriia Y Postupalenko; Volodymyr V Shvadchak; Vasyl G Pivovarenko; Andrey S Klymchenko; Yves Mély
Improved hydration-sensitive dual-fluorescence labels for monitoring peptide-nucleic acid interactions.
Bioconjugate chemistry 2011;22(1):101-7.
2011: V Y Postupalenko; Volodymyr V Shvadchak; Guy Duportail; Vasyl G Pivovarenko; Andrey S Klymchenko; Yves Mély
Monitoring membrane binding and insertion of peptides by two-color fluorescent label.
Biochimica et biophysica acta 2011;1808(1):424-32.
2010: Namrata Jain; Youri Arntz; Valérie Goldschmidt; Guy Duportail; Yves Mély; Andrey S Klymchenko
New unsymmetrical bolaamphiphiles: synthesis, assembly with DNA, and application for gene delivery.
Bioconjugate chemistry 2010;21(11):2110-8.
2010: Julien Godet; Yves Mély
Biophysical studies of the nucleic acid chaperone properties of the HIV-1 nucleocapsid protein.
RNA biology 2010;7(6):687-99.
2010: Vanille J Greiner; Caroline Egelé; Sule Oncul; Frédéric Ronzon; Catherine Manin; Andrey Klymchenko; Yves Mély
Characterization of the lipid and protein organization in HBsAg viral particles by steady-state and time-resolved fluorescence spectroscopy.
Biochimie 2010;92(8):994-1002.
2010: Yann Roche; Andrey S Klymchenko; Patricia Gerbeau-Pissot; Patrick Gervais; Yves Mély; Françoise Simon-Plas; Jean-Marie Perrier-Cornet
Behavior of plant plasma membranes under hydrostatic pressure as monitored by fluorescent environment-sensitive probes.
Biochimica et biophysica acta 2010;1798(8):1601-7.
2010: Christian Boudier; R Storchak; K K Sharma; P Didier; Anny Follenius-Wund; Sylviane Muller; Jean-Luc Darlix; Yves Mély
The mechanism of HIV-1 Tat-directed nucleic acid annealing supports its role in reverse transcription.
Journal of molecular biology 2010;400(3):487-501.
2010: Sule Oncul; Andrey S Klymchenko; Oleksandr A Kucherak; Alexander P Demchenko; Sophie Martin; Monique Dontenwill; Youri Arntz; Pascal Didier; Guy Duportail; Yves Mély
Liquid ordered phase in cell membranes evidenced by a hydration-sensitive probe: effects of cholesterol depletion and apoptosis.
Biochimica et biophysica acta 2010;1798(7):1436-43.
2010: Laurence Choulier; Volodymyr V Shvadchak; Aletia Naidoo; Andrey S Klymchenko; Yves Mély; Danièle Altschuh
A peptide-based fluorescent ratiometric sensor for quantitative detection of proteins.
Analytical biochemistry 2010;401(2):188-95.
2010: Kamal kant Sharma; Pascal Didier; Jean-Luc Darlix; Hugues de Rocquigny; Hayet Bensikaddour; Jean-Pierre Lavergne; François Pénin; Jean-Marc Lessinger; Yves Mély
Kinetic analysis of the nucleic acid chaperone activity of the hepatitis C virus core protein.
Nucleic acids research 2010;38(11):3632-42.
2010: Oleksandr A Kucherak; Sule Oncul; Zeinab Darwich; Dmytro A Yushchenko; Youri Arntz; Pascal Didier; Yves Mély; Andrey S Klymchenko
Switchable nile red-based probe for cholesterol and lipid order at the outer leaflet of biomembranes.
Journal of the American Chemical Society 2010;132(13):4907-16.
2010: Christophe Pannecouque; Beata Szafarowicz; Natalia Volkova; Vasiliy Bakulev; Wim Dehaen; Yves Mély; Dirk Daelemans
Inhibition of HIV-1 replication by a bis-thiadiazolbenzene-1,2-diamine that chelates zinc ions from retroviral nucleocapsid zinc fingers.
Antimicrobial agents and chemotherapy 2010;54(4):1461-8.
2010: Joëlle V Fritz; Denis Dujardin; Julien Godet; Pascal Didier; Jan De Mey; Jean-Luc Darlix; Yves Mély; Hugues de Rocquigny
HIV-1 Vpr oligomerization but not that of Gag directs the interaction between Vpr and Gag.
Journal of virology 2010;84(3):1585-96.
2010: Yoshiteru Sato; Nick Ramalanjaona; Tiphaine Huet; Noelle Potier; Judit Osz; Pierre Antony; Carole Peluso-Iltis; Pierre Poussin-Courmontagne; Eric Ennifar; Yves Mély; Annick Dejaegere; Dino Moras; Natacha Rochel
The "Phantom Effect" of the Rexinoid LG100754: structural and functional insights.
PloS one 2010;5(11):e15119.
2010: Khalid Amari; Emmanuel Boutant; Christina Hofmann; Corinne Schmitt-Keichinger; Lourdes Fernandez-Calvino; Pascal Didier; Alexander Lerich; Jérôme Mutterer; Carole L Thomas; Manfred Heinlein; Yves Mély; Andrew J Maule; Christophe Ritzenthaler
A family of plasmodesmal proteins with receptor-like properties for plant viral movement proteins.
PLoS pathogens 2010;6(9):e1001119.
2010: Paul Claudon; Aude Violette; Karen Lamour; Marion Decossas; Sylvie Fournel; Béatrice Heurtault; Julien Godet; Yves Mély; Brigitte Jamart-Grégoire; Marie-Christine Averlant-Petit; Jean-Paul Briand; Guy Duportail; Henri Monteil; Gilles Guichard
Consequences of isostructural main-chain modifications for the design of antimicrobial foldamers: helical mimics of host-defense peptides based on a heterogeneous amide/urea backbone.
Angewandte Chemie (International ed. in English) 2010;49(2):333-6.
2009: Ranjan Das; Andrey S Klymchenko; Guy Duportail; Yves Mély
Unusually slow proton transfer dynamics of a 3-hydroxychromone dye in protic solvents.
Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology 2009;8(11):1583-9.
2009: Ali Hayek; Frédéric Bolze; Cyril Bourgogne; Patrice L Baldeck; Pascal Didier; Youri Arntz; Yves Mély; Jean-François Nicoud
Boron containing two-photon absorbing chromophores. 2. Fine tuning of the one- and two-photon photophysical properties of pyrazabole based fluorescent bioprobes.
Inorganic chemistry 2009;48(19):9112-9.
2009: Pascal Didier; Gilles Ulrich; Yves Mély; Raymond Ziessel
Improved push-pull-push E-Bodipy fluorophores for two-photon cell-imaging.
Organic & biomolecular chemistry 2009;7(18):3639-42.
2009: Volodymyr V Shvadchak; Sarah Sanglier; Sandrine Rocle; Pascal Villa; jacques haiech; Marcel Hibert; Alain Van Dorsselaer; Yves Mély; Hugues de Rocquigny
Identification by high throughput screening of small compounds inhibiting the nucleic acid destabilization activity of the HIV-1 nucleocapsid protein.
Biochimie 2009;91(7):916-23.
2009: Alexander P Demchenko; Yves Mély; Guy Duportail; Andrey S Klymchenko
Monitoring biophysical properties of lipid membranes by environment-sensitive fluorescent probes.
Biophysical journal 2009;96(9):3461-70.
2009: Mykhailo D Bilokin'; Volodymyr V Shvadchak; Dmytro A Yushchenko; Guy Duportail; Yves Mély; Vasyl G Pivovarenko
Dual-fluorescence probe of environment basicity (hydrogen bond accepting ability) displaying no sensitivity to polarity.
Journal of fluorescence 2009;19(3):545-53.
2009: Pascal Didier; Julien Godet; Yves Mély
Two-photon two-focus fluorescence correlation spectroscopy with a tunable distance between the excitation volumes.
Journal of fluorescence 2009;19(3):561-5.
2009: Sergiy V Avilov; Julien Godet; Etienne Piémont; Yves Mély
Site-specific characterization of HIV-1 nucleocapsid protein binding to oligonucleotides with two binding sites.
Biochemistry 2009;48(11):2422-30.
2009: Volodymyr V Shvadchak; Andrey S Klymchenko; Hugues de Rocquigny; Yves Mély
Sensing peptide-oligonucleotide interactions by a two-color fluorescence label: application to the HIV-1 nucleocapsid protein.
Nucleic acids research 2009;37(3):e25.
2009: Andrey S Klymchenko; Sule Oncul; Pascal Didier; Emmanuel Schaub; Luis Bagatolli; Guy Duportail; Yves Mély
Visualization of lipid domains in giant unilamellar vesicles using an environment-sensitive membrane probe based on 3-hydroxyflavone.
Biochimica et biophysica acta 2009;1788(2):495-9.
2008: Sarah Bourbigot; Nick Ramalanjaona; Christian Boudier; Gilmar F J Salgado; Bernard P Roques; Yves Mély; Serge Bouaziz; Nelly Morellet
How the HIV-1 nucleocapsid protein binds and destabilises the (-)primer binding site during reverse transcription.
Journal of molecular biology 2008;383(5):1112-28.
2008: Dina Grohmann; Julien Godet; Yves Mély; Jean-Luc Darlix; Tobias Restle
HIV-1 nucleocapsid traps reverse transcriptase on nucleic acid substrates.
Biochemistry 2008;47(46):12230-40.
2008: Andrey S Klymchenko; Volodymyr V Shvadchak; Dmytro A Yushchenko; Namrata Jain; Yves Mély
Excited-state intramolecular proton transfer distinguishes microenvironments in single- and double-stranded DNA.
The journal of physical chemistry. B 2008;112(38):12050-5.
2008: Ranjan Das; Andrey S Klymchenko; Guy Duportail; Yves Mély
Excited state proton transfer and solvent relaxation of a 3-hydroxyflavone probe in lipid bilayers.
The journal of physical chemistry. B 2008;112(38):11929-35.
2008: Karin Enander; Laurence Choulier; A Linnéa Olsson; Dmytro A Yushchenko; Daniel Kanmert; Andrey S Klymchenko; Alexander P Demchenko; Yves Mély; Danièle Altschuh
A peptide-based, ratiometric biosensor construct for direct fluorescence detection of a protein analyte.
Bioconjugate chemistry 2008;19(9):1864-70.
2008: Cyril A Kenfack; Etienne Piémont; Nouha Ben Gaied; Alain Burger; Yves Mély
Time-resolved fluorescent properties of 8-vinyl-deoxyadenosine and 2-amino-deoxyribosylpurine exhibit different sensitivity to their opposite base in duplexes.
The journal of physical chemistry. B 2008;112(32):9736-45.
2008: Xin Zhang; Kamal Kant Sharma; Marcel Boeglin; Joëlle Ogier; Didier Mainard; Jean-Claude Voegel; Yves Mély; Nadia Benkirane-Jessel
Transfection ability and intracellular DNA pathway of nanostructured gene-delivery systems.
Nano letters 2008;8(8):2432-6.
2008: Gora M'Baye; Yves Mély; Guy Duportail; Andrey S Klymchenko
Liquid ordered and gel phases of lipid bilayers: fluorescent probes reveal close fluidity but different hydration.
Biophysical journal 2008;95(3):1217-25.
2008: Monika Kuciak; Caroline Gabus; Roland Ivanyi-Nagy; Katharina Semrad; Roman Storchak; Olivier Chaloin; Sylviane Muller; Yves Mély; Jean-Luc Darlix
The HIV-1 transcriptional activator Tat has potent nucleic acid chaperoning activities in vitro.
Nucleic acids research 2008;36(10):3389-400.
2008: Katrin Brandner; Adrian Sambade; Emmanuel Boutant; Pascal Didier; Yves Mély; Christophe Ritzenthaler; Manfred Heinlein
Tobacco mosaic virus movement protein interacts with green fluorescent protein-tagged microtubule end-binding protein 1.
Plant physiology 2008;147(2):611-23.
2008: Xin Zhang; Sebnem Ercelen; Guy Duportail; Emmanuel Schaub; Vladimir Tikhonov; Alexander Slita; Vladimir Zarubaev; Valery Babak; Yves Mély
Hydrophobically modified low molecular weight chitosans as efficient and nontoxic gene delivery vectors.
The journal of gene medicine 2008;10(5):527-39.
2008: Julia Dietz; Joachim Koch; Ajit Kaur; Chinnappan Raja; Stefan Stein; Manuel Grez; Anette Pustowka; Sarah Mensch; Jan Ferner; Lars Möller; Norbert Bannert; Robert Tampé; Gilles Divita; Yves Mély; Harald Schwalbe; Ursula Dietrich
Inhibition of HIV-1 by a peptide ligand of the genomic RNA packaging signal Psi.
ChemMedChem 2008;3(5):749-55.
2008: Moussa Ouedraogo; Sandra Lecat; Moulay Driss Rochdi; Muriel Hachet-Haas; Hans Matthes; Hervé Gicquiaux; Sophie Verrier; Mireille Gaire; Nicole Glasser; Yves Mély; Kenneth Takeda; Michel Bouvier; Jean-Luc Galzi; Bernard Bucher
Distinct motifs of neuropeptide Y receptors differentially regulate trafficking and desensitization.
Traffic (Copenhagen, Denmark) 2008;9(3):305-24.
2008: Sergiy V Avilov; E Piemont; Volodymyr V Shvadchak; Hugues de Rocquigny; Yves Mély
Probing dynamics of HIV-1 nucleocapsid protein/target hexanucleotide complexes by 2-aminopurine.
Nucleic acids research 2008;36(3):885-96.
2008: Joëlle V Fritz; Pascal Didier; Jean-Pierre Clamme; Emmanuel Schaub; Delphine Muriaux; Charlotte Cabanne; Nelly Morellet; Serge Bouaziz; Jean-Luc Darlix; Yves Mély; Hugues de Rocquigny
Direct Vpr-Vpr interaction in cells monitored by two photon fluorescence correlation spectroscopy and fluorescence lifetime imaging.
Retrovirology 2008;5():87.
2008: Caroline Egelé; pascale barbier; Pascal Didier; Etienne Piémont; Diane Allegro; Olivier Chaloin; Sylviane Muller; Vincent Peyrot; Yves Mély
Modulation of microtubule assembly by the HIV-1 Tat protein is strongly dependent on zinc binding to Tat.
Retrovirology 2008;5():62.
2008: Ben Berkhout; Robert Gorelick; Michael F Summers; Yves Mély; Jean-Luc Darlix
6th international symposium on retroviral nucleocapsid.
Retrovirology 2008;5():21.
2008: Hugues de Rocquigny; Volodymyr V Shvadchak; Sergiy V Avilov; Chang-Zhi Dong; Ursula Dietrich; Jean-Luc Darlix; Yves Mély
Targeting the viral nucleocapsid protein in anti-HIV-1 therapy.
Mini reviews in medicinal chemistry 2008;8(1):24-35.
2007: Caroline Egelé; Etienne Piémont; Pascal Didier; Damien Ficheux; Bernard Roques; Jean-Luc Darlix; Hugues de Rocquigny; Yves Mély
The single-finger nucleocapsid protein of moloney murine leukemia virus binds and destabilizes the TAR sequences of HIV-1 but does not promote efficiently their annealing.
Biochemistry 2007;46(50):14650-62.
2007: Nick Ramalanjaona; Hugues de Rocquigny; Aurélie Millet; Damien Ficheux; Jean-Luc Darlix; Yves Mély
Investigating the mechanism of the nucleocapsid protein chaperoning of the second strand transfer during HIV-1 DNA synthesis.
Journal of molecular biology 2007;374(4):1041-53.
2007: Dmytro A Yushchenko; Volodymyr V Shvadchak; Andrey S Klymchenko; Guy Duportail; Vasyl G Pivovarenko; Yves Mély
Modulation of excited-state intramolecular proton transfer by viscosity in protic media.
The journal of physical chemistry. A 2007;111(42):10435-8.
2007: Dmytro A Yushchenko; Olga B Vadzyuk; Sergiy O Kosterin; Guy Duportail; Yves Mély; Vasyl G Pivovarenko
Sensing of adenosine-5'-triphosphate anion in aqueous solutions and mitochondria by a fluorescent 3-hydroxyflavone dye.
Analytical biochemistry 2007;369(2):218-25.
2007: Ali Hayek; Alexei Grichine; Thomas Huault; Clément Ricard; Frédéric Bolze; Boudewijn van der Sanden; Jean-Claude Vial; Yves Mély; Alain Duperray; Patrice L Baldeck; Jean-François Nicoud
Cell-permeant cytoplasmic blue fluorophores optimized for in vivo two-photon microscopy with low-power excitation.
Microscopy research and technique 2007;70(10):880-5.
2007: Dmytro A Yushchenko; Volodymyr V Shvadchak; Andrey S Klymchenko; Guy Duportail; Vasyl G Pivovarenko; Yves Mély
Steric control of the excited-state intramolecular proton transfer in 3-hydroxyquinolones: steady-state and time-resolved fluorescence study.
The journal of physical chemistry. A 2007;111(37):8986-92.
2007: Elisa Bombarda; Ernst Grell; Bernard P Roques; Yves Mély
Molecular mechanism of the Zn2+-induced folding of the distal CCHC finger motif of the HIV-1 nucleocapsid protein.
Biophysical journal 2007;93(1):208-17.
2007: Ali Hayek; Sebnem Ercelen; Xin Zhang; Frédéric Bolze; Jean-François Nicoud; Emmanuel Schaub; Patrice L Baldeck; Yves Mély
Conjugation of a new two-photon fluorophore to poly(ethylenimine) for gene delivery imaging.
Bioconjugate chemistry 2007;18(3):844-51.
2007: Chouaib Tahtaoui; Cécile Thomas; François Rohmer; Philippe Klotz; Guy Duportail; Yves Mély; Dominique Bonnet; Marcel Hibert
Convenient method to access new 4,4-dialkoxy- and 4,4-diaryloxy-diaza-s-indacene dyes: Synthesis and spectroscopic evaluation.
The Journal of organic chemistry 2007;72(1):269-72.
2007: Jean-Luc Darlix; José Luis Garrido; Nelly Morellet; Yves Mély; Hugues de Rocquigny
Properties, functions, and drug targeting of the multifunctional nucleocapsid protein of the human immunodeficiency virus.
Advances in pharmacology (San Diego, Calif.) 2007;55():299-346.
2007: Gora M'Baye; Andrey S Klymchenko; Dmytro A Yushchenko; Volodymyr V Shvadchak; Turan Ozturk; Yves Mély; Guy Duportail
Fluorescent dyes undergoing intramolecular proton transfer with improved sensitivity to surface charge in lipid bilayers.
Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology 2007;6(1):71-6.
2006: Cyril A Kenfack; Alain Burger; Yves Mély
Excited-state properties and transitions of fluorescent 8-vinyl adenosine in DNA.
The journal of physical chemistry. B 2006;110(51):26327-36.
2006: Dmytro A Yushchenko; Volodymyr V Shvadchak; Mykhailo D Bilokin'; Andrey S Klymchenko; Guy Duportail; Yves Mély; Vasyl G Pivovarenko
Modulation of dual fluorescence in a 3-hydroxyquinolone dye by perturbation of its intramolecular proton transfer with solvent polarity and basicity.
Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology 2006;5(11):1038-44.
2006: Sebnem Ercelen; Xin Zhang; Guy Duportail; Christian Grandfils; Jacques Desbrières; Svetlana Karaeva; Vladimir Tikhonov; Yves Mély; Valery Babak
Physicochemical properties of low molecular weight alkylated chitosans: a new class of potential nonviral vectors for gene delivery.
Colloids and surfaces. B, Biointerfaces 2006;51(2):140-8.
2006: Chinappan Raja; Jan Ferner; Ursula Dietrich; Sergiy Avilov; Damien Ficheux; Jean-Luc Darlix; Hugues de Rocquigny; Harald Schwalbe; Yves Mély
A tryptophan-rich hexapeptide inhibits nucleic acid destabilization chaperoned by the HIV-1 nucleocapsid protein.
Biochemistry 2006;45(30):9254-65.
2006: Andrey S Klymchenko; Herrade Stoeckel; Kenneth Takeda; Yves Mély
Fluorescent probe based on intramolecular proton transfer for fast ratiometric measurement of cellular transmembrane potential.
The journal of physical chemistry. B 2006;110(27):13624-32.
2006: Julien Godet; Hugues de Rocquigny; Chinnappan Raja; Nicole Glasser; Damien Ficheux; Jean-Luc Darlix; Yves Mély
During the early phase of HIV-1 DNA synthesis, nucleocapsid protein directs hybridization of the TAR complementary sequences via the ends of their double-stranded stem.
Journal of molecular biology 2006;356(5):1180-92.
2006: Gora M'Baye; Vasyl V Shynkar; Andrey S Klymchenko; Yves Mély; Guy Duportail
Membrane dipole potential as measured by ratiometric 3-hydroxyflavone fluorescence probes: accounting for hydration effects.
Journal of fluorescence 2006;16(1):35-42.
2006: Ali Hayek; Frédéric Bolze; Jean-François Nicoud; Patrice L Baldeck; Yves Mély
Synthesis and characterization of water-soluble two-photon excited blue fluorescent chromophores for bioimaging.
Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology 2006;5(1):102-6.
2005: Caroline Egelé; Emmanuel Schaub; Etienne Piémont; Hugues de Rocquigny; Yves Mély
Investigation by fluorescence correlation spectroscopy of the chaperoning interactions of HIV-1 nucleocapsid protein with the viral DNA initiation sequences.
Comptes rendus biologies 2005;328(12):1041-51.
2005: Vasyl V Shynkar; Andrey S Klymchenko; Guy Duportail; Alexander P Demchenko; Yves Mély
Two-color fluorescent probes for imaging the dipole potential of cell plasma membranes.
Biochimica et biophysica acta 2005;1712(2):128-36.
2005: Sebnem Ercelen; Andrey S Klymchenko; Yves Mély; Alexander P Demchenko
The binding of novel two-color fluorescence probe FA to serum albumins of different species.
International journal of biological macromolecules 2005;35(5):231-42.
2005: Hervé Beltz; Céline Clauss; Etienne Piémont; Damien Ficheux; Robert J Gorelick; Bernard P Roques; Caroline Gabus; Jean-Luc Darlix; Hugues de Rocquigny; Yves Mély
Structural determinants of HIV-1 nucleocapsid protein for cTAR DNA binding and destabilization, and correlation with inhibition of self-primed DNA synthesis.
Journal of molecular biology 2005;348(5):1113-26.
2005: Elisa Bombarda; Bernard P Roques; Yves Mély; Ernst Grell
Mechanism of zinc coordination by point-mutated structures of the distal CCHC binding motif of the HIV-1 NCp7 protein.
Biochemistry 2005;44(19):7315-25.
2005: Sarah Bourbigot; Hervé Beltz; Jérôme Denis; Nelly Morellet; Bernard P Roques; Yves Mély; Serge Bouaziz
The C-terminal domain of the HIV-1 regulatory protein Vpr adopts an antiparallel dimeric structure in solution via its leucine-zipper-like domain.
The Biochemical journal 2005;387(Pt 2):333-41.
2005: Nouha Ben Gaied; Nicole Glasser; Nick Ramalanjaona; Hervé Beltz; Philippe Wolff; Roland Marquet; Alain Burger; Yves Mély
8-vinyl-deoxyadenosine, an alternative fluorescent nucleoside analog to 2'-deoxyribosyl-2-aminopurine with improved properties.
Nucleic acids research 2005;33(3):1031-9.
2004: Andrey S Klymchenko; Yves Mély; Alexander P Demchenko; Guy Duportail
Simultaneous probing of hydration and polarity of lipid bilayers with 3-hydroxyflavone fluorescent dyes.
Biochimica et biophysica acta 2004;1665(1-2):6-19.
2004: Caroline Egelé; Emmanuel Schaub; Nick Ramalanjaona; Etienne Piémont; Damien Ficheux; Bernard P Roques; Jean-Luc Darlix; Yves Mély
HIV-1 nucleocapsid protein binds to the viral DNA initiation sequences and chaperones their kissing interactions.
Journal of molecular biology 2004;342(2):453-66.
2004: Roland H Stote; Esther Kellenberger; Hervé Muller; Elisa Bombarda; Bernard P Roques; Bruno Kieffer; Yves Mély
Structure of the His44 --> Ala single point mutant of the distal finger motif of HIV-1 nucleocapsid protein: a combined NMR, molecular dynamics simulation, and fluorescence study.
Biochemistry 2004;43(24):7687-97.
2004: Hervé Beltz; Etienne Piémont; Emmanuel Schaub; Damien Ficheux; Bernard P Roques; Jean-Luc Darlix; Yves Mély
Role of the structure of the top half of HIV-1 cTAR DNA on the nucleic acid destabilizing activity of the nucleocapsid protein NCp7.
Journal of molecular biology 2004;338(4):711-23.
2004: Andrey S Klymchenko; Guy Duportail; Alexander P Demchenko; Yves Mély
Bimodal distribution and fluorescence response of environment-sensitive probes in lipid bilayers.
Biophysical journal 2004;86(5):2929-41.
2004: David Llères; Jean-Marc Weibel; Denis Heissler; Guy Zuber; Guy Duportail; Yves Mély
Dependence of the cellular internalization and transfection efficiency on the structure and physicochemical properties of cationic detergent/DNA/liposomes.
The journal of gene medicine 2004;6(4):415-28.
2003: Paul Ramos; Thierry Coste; Etienne Piémont; Jean-Marc Lessinger; Jean Alain Bousquet; Catherine Chapus; Brigitte Kerfelec; Georges Férard; Yves Mély
Time-resolved fluorescence allows selective monitoring of Trp30 environmental changes in the seven-Trp-containing human pancreatic lipase.
Biochemistry 2003;42(43):12488-96.
2003: Jean-Pierre Clamme; Guruswamy Krishnamoorthy; Yves Mély
Intracellular dynamics of the gene delivery vehicle polyethylenimine during transfection: investigation by two-photon fluorescence correlation spectroscopy.
Biochimica et biophysica acta 2003;1617(1-2):52-61.
2003: Emmanuelle Pion; Elisa Bombarda; Patrick Stiegler; G Matthias Ullmann; Yves Mély; Gilbert de Murcia; Dominique Gérard
Poly(ADP-ribose) polymerase-1 dimerizes at a 5' recessed DNA end in vitro: a fluorescence study.
Biochemistry 2003;42(42):12409-17.
2003: Andrey S Klymchenko; Guy Duportail; Yves Mély; Alexander P Demchenko
Ultrasensitive two-color fluorescence probes for dipole potential in phospholipid membranes.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(20):11219-24.
2003: Guruswamy Krishnamoorthy; Bernard P Roques; Jean-Luc Darlix; Yves Mély
DNA condensation by the nucleocapsid protein of HIV-1: a mechanism ensuring DNA protection.
Nucleic acids research 2003;31(18):5425-32.
2003: Hervé Beltz; Joel Azoulay; Serena Bernacchi; Jean-Pierre Clamme; Damien Ficheux; Bernard P Roques; Jean-Luc Darlix; Yves Mély
Impact of the terminal bulges of HIV-1 cTAR DNA on its stability and the destabilizing activity of the nucleocapsid protein NCp7.
Journal of molecular biology 2003;328(1):95-108.
2003: Jean-Pierre Clamme; Joel Azoulay; Yves Mély
Monitoring of the formation and dissociation of polyethylenimine/DNA complexes by two photon fluorescence correlation spectroscopy.
Biophysical journal 2003;84(3):1960-8.
2003: Joel Azoulay; Jean-Pierre Clamme; Jean-Luc Darlix; Bernard P Roques; Yves Mély
Destabilization of the HIV-1 complementary sequence of TAR by the nucleocapsid protein through activation of conformational fluctuations.
Journal of molecular biology 2003;326(3):691-700.
2003: Jean-Alain Bousquet; Jérôme Duranton; Yves Mély; Joseph G Bieth
Conformational change in elastase following complexation with alpha1-proteinase inhibitor: a CD investigation.
The Biochemical journal 2003;370(Pt 1):345-9.
2003: Hélène M Courrier; Marie Pierre Krafft; N Butz; C Porté; N Frossard; A Rémy-Kristensen; Yves Mély; F Pons; Thierry F Vandamme
Evaluation of cytotoxicity of new semi-fluorinated amphiphiles derived from dimorpholinophosphate.
Biomaterials 2003;24(4):689-96.
2003: Serena Bernacchi; Etienne Piémont; Noelle Potier; Alain Van Dorsselaer; Yves Mély
Excitonic heterodimer formation in an HIV-1 oligonucleotide labeled with a donor-acceptor pair used for fluorescence resonance energy transfer.
Biophysical journal 2003;84(1):643-54.
2002: Guruswamy Krishnamoorthy; Guy Duportail; Yves Mély
Structure and dynamics of condensed DNA probed by 1,1'-(4,4,8,8-tetramethyl-4,8-diazaundecamethylene)bis[4-[[3- methylbenz-1,3-oxazol-2-yl]methylidine]-1,4-dihydroquinolinium] tetraiodide fluorescence.
Biochemistry 2002;41(51):15277-87.
2002: Andrey S Klymchenko; Guy Duportail; Turan Ozturk; Vasyl G Pivovarenko; Yves Mély; Alexander P Demchenko
Novel two-band ratiometric fluorescence probes with different location and orientation in phospholipid membranes.
Chemistry & biology 2002;9(11):1199-208.
2002: Philippe Mellet; Yves Mély; Lizbeth Hedstrom; Marguerite Cahoon; Didier Belorgey; Narayanan Srividya; Harvey Rubin; Joseph G Bieth
Comparative trajectories of active and S195A inactive trypsin upon binding to serpins.
The Journal of biological chemistry 2002;277(41):38901-14.
2002: Elisa Bombarda; H Cherradi; Nelly Morellet; Bernard P Roques; Yves Mély
Zn(2+) binding properties of single-point mutants of the C-terminal zinc finger of the HIV-1 nucleocapsid protein: evidence of a critical role of cysteine 49 in Zn(2+) dissociation.
Biochemistry 2002;41(13):4312-20.
2002: Serena Bernacchi; Stoyl Stoylov; Etienne Piémont; Damien Ficheux; Bernard P Roques; Jean-Luc Darlix; Yves Mély
HIV-1 nucleocapsid protein activates transient melting of least stable parts of the secondary structure of TAR and its complementary sequence.
Journal of molecular biology 2002;317(3):385-99.
2002: Stéphanie Ramboarina; Narayanan Srividya; R Andrew Atkinson; Nelly Morellet; Bernard P Roques; Jean-François Lefèvre; Yves Mély; Bruno Kieffer
Effects of temperature on the dynamic behaviour of the HIV-1 nucleocapsid NCp7 and its DNA complex.
Journal of molecular biology 2002;316(3):611-27.
2002: Hervé Gicquiaux; Sandra Lecat; Mireille Gaire; Alain Dieterlen; Yves Mély; Kenneth Takeda; Bernard Bucher; Jean-Luc Galzi
Rapid internalization and recycling of the human neuropeptide Y Y(1) receptor.
The Journal of biological chemistry 2002;277(8):6645-55.
2001: A Rémy-Kristensen; Jean-Pierre Clamme; C Vuilleumier; JG Kuhry; Yves Mély
Role of endocytosis in the transfection of L929 fibroblasts by polyethylenimine/DNA complexes.
Biochimica et biophysica acta 2001;1514(1):21-32.
2001: Elisa Bombarda; Nelly Morellet; H Cherradi; Bernard Spiess; Serge Bouaziz; Ernst Grell; Bernard P Roques; Yves Mély
Determination of the pK(a) of the four Zn2+-coordinating residues of the distal finger motif of the HIV-1 nucleocapsid protein: consequences on the binding of Zn2+.
Journal of molecular biology 2001;310(3):659-72.
2001: Serena Bernacchi; Yves Mély
Exciton interaction in molecular beacons: a sensitive sensor for short range modifications of the nucleic acid structure.
Nucleic acids research 2001;29(13):E62-2.
2001: D Lleres; Emmanuel Dauty; J P Behr; Yves Mély; Guy Duportail
DNA condensation by an oxidizable cationic detergent. Interactions with lipid vesicles.
Chemistry and physics of lipids 2001;111(1):59-71.
2000: Jean-Pierre Clamme; Serena Bernacchi; C Vuilleumier; Guy Duportail; Yves Mély
Gene transfer by cationic surfactants is essentially limited by the trapping of the surfactant/DNA complexes onto the cell membrane: a fluorescence investigation.
Biochimica et biophysica acta 2000;1467(2):347-61.
2000: J A Bousquet; C Garbay; Bernard P Roques; Yves Mély
Circular dichroic investigation of the native and non-native conformational states of the growth factor receptor-binding protein 2 N-terminal src homology domain 3: effect of binding to a proline-rich peptide from guanine nucleotide exchange factor.
Biochemistry 2000;39(26):7722-35.
1999: C Vuilleumier; Elisa Bombarda; Nelly Morellet; Dominique Gérard; Bernard P Roques; Yves Mély
Nucleic acid sequence discrimination by the HIV-1 nucleocapsid protein NCp7: a fluorescence study.
Biochemistry 1999;38(51):16816-25.
1999: Elisa Bombarda; A Ababou; C Vuilleumier; Dominique Gérard; Bernard P Roques; Etienne Piémont; Yves Mély
Time-resolved fluorescence investigation of the human immunodeficiency virus type 1 nucleocapsid protein: influence of the binding of nucleic acids.
Biophysical journal 1999;76(3):1561-70.
1998: Eric Le Cam; Dominique Coulaud; Etienne Delain; P Petitjean; Bernard P Roques; Dominique Gérard; E Stoylova; C Vuilleumier; Stoyl Stoylov; Yves Mély
Properties and growth mechanism of the ordered aggregation of a model RNA by the HIV-1 nucleocapsid protein: an electron microscopy investigation.
Biopolymers 1998;45(3):217-29.
1997: Yves Mély; Martine Cadene; I Sylte; Joseph G Bieth
Mapping the suramin-binding sites of human neutrophil elastase: investigation by fluorescence resonance energy transfer and molecular modeling.
Biochemistry 1997;36(50):15624-31.
1997: Stoyl Stoylov; C Vuilleumier; E Stoylova; Hugues de Rocquigny; Bernard P Roques; Dominique Gérard; Yves Mély
Ordered aggregation of ribonucleic acids by the human immunodeficiency virus type 1 nucleocapsid protein.
Biopolymers 1997;41(3):301-12.
1997: C Vuilleumier; C Maechling-Strasser; Dominique Gérard; Yves Mély
Evidence and prevention of HIV-1 nucleocapsid protein adsorption onto fluorescence quartz cells.
Analytical biochemistry 1997;244(1):183-5.
1996: Yves Mély; Hugues de Rocquigny; Nelly Morellet; Bernard P Roques; D Gérad
Zinc binding to the HIV-1 nucleocapsid protein: a thermodynamic investigation by fluorescence spectroscopy.
Biochemistry 1996;35(16):5175-82.
1995: Yves Mély; Hugues de Rocquigny; M Sorinas-Jimeno; G Keith; Bernard P Roques; R Marquet; Dominique Gérard
Binding of the HIV-1 nucleocapsid protein to the primer tRNA(3Lys), in vitro, is essentially not specific.
The Journal of biological chemistry 1995;270(4):1650-6.
1994: Yves Mély; N Jullian; Nelly Morellet; Hugues de Rocquigny; C Z Dong; Etienne Piémont; Bernard P Roques; Dominique Gérard
Spatial proximity of the HIV-1 nucleocapsid protein zinc fingers investigated by time-resolved fluorescence and fluorescence resonance energy transfer.
Biochemistry 1994;33(40):12085-91.
1994: Nelly Morellet; Hugues de Rocquigny; Yves Mély; N Jullian; H Déméné; M Ottmann; Dominique Gérard; Jean-Luc Darlix; MC Fournie-Zaluski; Bernard P Roques
Conformational behaviour of the active and inactive forms of the nucleocapsid NCp7 of HIV-1 studied by 1H NMR.
Journal of molecular biology 1994;235(1):287-301.
1993: Yves Mély; Etienne Piémont; M Sorinas-Jimeno; Hugues de Rocquigny; N Jullian; Nelly Morellet; Bernard P Roques; Dominique Gérard
Structural and dynamic characterization of the aromatic amino acids of the human immunodeficiency virus type I nucleocapsid protein zinc fingers and their involvement in heterologous tRNA(Phe) binding: a steady-state and time-resolved fluorescence study.
Biophysical journal 1993;65(4):1513-22.