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Andrea Mencarelli

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Barbara Renga; Angela Zampella; Daniela Francisci; Andrea Mencarelli; Angela Bruno; Adriana Carino; Sabrina Cipriani; Claudio D'Amore; Eleonora Distrutti; Stefano Fiorucci
The bile acid sensor FXR is required for immune-regulatory activities of TLR-9 in intestinal inflammation.
Sabrina Cipriani; Eleonora Distrutti; Franco Baldelli; Angela Bruno; Andrea Mencarelli; Barbara Renga; Luca Santucci; Stefano Fiorucci
Activation of the bile acid receptor GPBAR1 protects against gastrointestinal injury caused by non-steroidal anti-inflammatory drugs and aspirin in mice.
Carmen Festa; Stefano Fiorucci; Gianluigi Lauro; Andrea Mencarelli; Maria Chiara Monti; Sylvain Petek; Barbara Renga; Giuseppe Bifulco; Agostino Casapullo; Claudio D'Amore; Maria Valeria D'auria; Simona De Marino; Angela Zampella
Plakilactones from the marine sponge Plakinastrella mamillaris. Discovery of a new class of marine ligands of peroxisome proliferator-activated receptor γ.

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All Publications

2013: Barbara Renga; Angela Zampella; Daniela Francisci; Andrea Mencarelli; Angela Bruno; Adriana Carino; Sabrina Cipriani; Claudio D'Amore; Eleonora Distrutti; Stefano Fiorucci
The bile acid sensor FXR is required for immune-regulatory activities of TLR-9 in intestinal inflammation.
PloS one 2013;8(1):e54472.
2013: Sabrina Cipriani; Eleonora Distrutti; Franco Baldelli; Angela Bruno; Andrea Mencarelli; Barbara Renga; Luca Santucci; Stefano Fiorucci
Activation of the bile acid receptor GPBAR1 protects against gastrointestinal injury caused by non-steroidal anti-inflammatory drugs and aspirin in mice.
British journal of pharmacology 2013;168(1):225-37.
2012: Carmen Festa; Stefano Fiorucci; Gianluigi Lauro; Andrea Mencarelli; Maria Chiara Monti; Sylvain Petek; Barbara Renga; Giuseppe Bifulco; Agostino Casapullo; Claudio D'Amore; Maria Valeria D'auria; Simona De Marino; Angela Zampella
Plakilactones from the marine sponge Plakinastrella mamillaris. Discovery of a new class of marine ligands of peroxisome proliferator-activated receptor γ.
Journal of medicinal chemistry 2012;55(19):8303-17.
2012: Barbara Renga; Angela Zampella; Andrea Mencarelli; Franco Baldelli; Sabrina Cipriani; Claudio D'Amore; Eleonora Distrutti; Stefano Fiorucci
Glucocorticoid receptor mediates the gluconeogenic activity of the farnesoid X receptor in the fasting condition.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2012;26(7):3021-31.
2012: Stefano Fiorucci; Andrea Mencarelli; Eleonora Distrutti; Angela Zampella
Farnesoid X receptor: from medicinal chemistry to clinical applications.
Future medicinal chemistry 2012;4(7):877-91.
2012: Luigi Margarucci; Andrea Mencarelli; Maria Chiara Monti; Raffaele Riccio; Angela Zampella; Chiara Cassiano; Stefano Fiorucci; Agostino Casapullo
Heat shock proteins as key biological targets of the marine natural cyclopeptide perthamide C.
Molecular bioSystems 2012;8(5):1412-7.
2012: Simona De Marino; Stefano Fiorucci; Andrea Mencarelli; Sylvain Petek; Barbara Renga; Raffaella Ummarino; Giuseppe Bifulco; Maria Giovanna Chini; Claudio D'Amore; Maria Valeria D'auria; Angela Zampella
4-Methylenesterols from Theonella swinhoei sponge are natural pregnane-X-receptor agonists and farnesoid-X-receptor antagonists that modulate innate immunity.
Steroids 2012;77(5):484-95.
2012: Andrea Mencarelli; Barbara Renga; Angela Bruno; Sabrina Cipriani; Claudio D'Amore; Eleonora Distrutti; Stefano Fiorucci
VSL#3 resets insulin signaling and protects against NASH and atherosclerosis in a model of genetic dyslipidemia and intestinal inflammation.
PloS one 2012;7(9):e45425.
2012: Barbara Renga; Elisabetta Schiaroli; Daniela Francisci; Andrea Mencarelli; Franco Baldelli; Sabrina Cipriani; Claudio D'Amore; Stefano Fiorucci
The HIV matrix protein p17 subverts nuclear receptors expression and induces a STAT1-dependent proinflammatory phenotype in monocytes.
PloS one 2012;7(4):e35924.
2012: Andrea Mencarelli; Barbara Renga; Elisabetta Schiaroli; Daniela Francisci; Franco Baldelli; Flavia Basile; Sabrina Cipriani; Claudio D'Amore; Stefano Fiorucci
Ritonavir-induced lipoatrophy and dyslipidaemia is reversed by the anti-inflammatory drug leflunomide in a PPAR-γ-dependent manner.
Antiviral therapy 2012;17(4):669-78.
2012: Barbara Renga; Valentina Sepe; Angela Zampella; Andrea Mencarelli; Maria Chiara Monti; Giuseppe Bifulco; Maria Giovanna Chini; Sabrina Cipriani; Claudio D'Amore; Maria Valeria D'auria; Stefano Fiorucci
Discovery that theonellasterol a marine sponge sterol is a highly selective FXR antagonist that protects against liver injury in cholestasis.
PloS one 2012;7(1):e30443.
2012: Barbara Renga; Andrea Mencarelli; Sabrina Cipriani; Eleonora Distrutti
Molecular determinants of gastrointestinal and liver cancers: role of bile acid activated nuclear receptors.
Current topics in medicinal chemistry 2012;12(6):625-36.
2011: Stefano Fiorucci; Andrea Mencarelli; Giuseppe Palladino; Barbara Renga; Luca Santucci; Sabrina Cipriani; Eleonora Distrutti
Activation of the farnesoid-X receptor protects against gastrointestinal injury caused by non-steroidal anti-inflammatory drugs in mice.
British journal of pharmacology 2011;164(8):1929-38.
2011: Barbara Renga; Angela Zampella; Andrea Mencarelli; Maria Chiara Monti; Sabrina Cipriani; Claudio D'Amore; Eleonora Distrutti; Stefano Fiorucci
The nuclear receptor FXR regulates hepatic transport and metabolism of glutamine and glutamate.
Biochimica et biophysica acta 2011;1812(11):1522-31.
2011: Andrea Mencarelli; Giuseppe Palladino; Barbara Renga; Patrizia Ricci; Franco Baldelli; Miriam Barbanti; D'Amore Claudio; Eleonora Distrutti; Stefano Fiorucci
Inhibition of NF-κB by a PXR-dependent pathway mediates counter-regulatory activities of rifaximin on innate immunity in intestinal epithelial cells.
European journal of pharmacology 2011;668(1-2):317-24.
2011: Andrea Mencarelli; Giuseppe Palladino; Barbara Renga; Gregory Tudor; Catherine Booth; Micheal Burnet; Sabrina Cipriani; Eleonora Distrutti; Jan-Hinrich Guse; Ulrike Hahn; Stefano Fiorucci
Development of non-antibiotic macrolide that corrects inflammation-driven immune dysfunction in models of inflammatory bowel diseases and arthritis.
European journal of pharmacology 2011;665(1-3):29-39.
2011: S Fiorucci; Andrea Mencarelli; F Baldelli; G Bifulco; S Cipriani; Angela Zampella
Farnesoid X receptor agonist for the treatment of liver and metabolic disorders: focus on 6-ethyl-CDCA.
Mini reviews in medicinal chemistry 2011;11(9):753-62.
2011: Valentina Sepe; Raffaella Ummarino; Angela Zampella; Claudio D'Amore; Maria Valeria D'auria; Andrea Mencarelli; Barbara Renga; Stefano Fiorucci
Total synthesis and pharmacological characterization of solomonsterol A, a potent marine pregnane-X-receptor agonist endowed with anti-inflammatory activity.
Journal of medicinal chemistry 2011;54(13):4590-9.
2011: Barbara Renga; Andrea Mencarelli; Marco Migliorati; Sabrina Cipriani; Claudio D'Amore; Eleonora Distrutti; Stefano Fiorucci
SHP-dependent and -independent induction of peroxisome proliferator-activated receptor-γ by the bile acid sensor farnesoid X receptor counter-regulates the pro-inflammatory phenotype of liver myofibroblasts.
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2011;60(6):577-87.
2011: Sabrina Cipriani; Andrea Mencarelli
Hydrogen sulfide in gastrointestinal and liver physiopathology.
Inflammation & allergy drug targets 2011;10(2):92-102.
2011: Barbara Renga; Marco Migliorati; Andrea Mencarelli; Sabrina Cipriani; Claudio D'Amore; Eleonora Distrutti; Stefano Fiorucci
Farnesoid X receptor suppresses constitutive androstane receptor activity at the multidrug resistance protein-4 promoter.
Biochimica et biophysica acta 2011;1809(3):157-65.
2011: Sabrina Cipriani; Eleonora Distrutti; Annibale Donini; Franco Baldelli; Giuseppe Bifulco; Maria Giovanna Chini; Andrea Mencarelli; Barbara Renga; Stefano Fiorucci
The bile acid receptor GPBAR-1 (TGR5) modulates integrity of intestinal barrier and immune response to experimental colitis.
PloS one 2011;6(10):e25637.
2011: Andrea Mencarelli; Giuseppe Palladino; Barbara Renga; Patrizia Ricci; Sabrina Cipriani; Claudio D'Amore; Eleonora Distrutti; Annibale Donini; Stefano Fiorucci
Probiotics modulate intestinal expression of nuclear receptor and provide counter-regulatory signals to inflammation-driven adipose tissue activation.
PloS one 2011;6(7):e22978.
2010: Andrea Mencarelli; Marco Migliorati; Miriam Barbanti; Sabrina Cipriani; Giuseppe Palladino; Eleonora Distrutti; Barbara Renga; Stefano Fiorucci
Pregnane-X-receptor mediates the anti-inflammatory activities of rifaximin on detoxification pathways in intestinal epithelial cells.
Biochemical pharmacology 2010;80(11):1700-7.
2010: Stefano Fiorucci; Sabrina Cipriani; Andrea Mencarelli; Barbara Renga; Eleonora Distrutti; Franco Baldelli
Counter-regulatory role of bile acid activated receptors in immunity and inflammation.
Current molecular medicine 2010;10(6):579-95.
2010: Stefano Fiorucci; Sabrina Cipriani; Franco Baldelli; Andrea Mencarelli
Bile acid-activated receptors in the treatment of dyslipidemia and related disorders.
Progress in lipid research 2010;49(2):171-85.
2010: Sabrina Cipriani; Andrea Mencarelli; Giuseppe Palladino; Stefano Fiorucci
FXR activation reverses insulin resistance and lipid abnormalities and protects against liver steatosis in Zucker (fa/fa) obese rats.
Journal of lipid research 2010;51(4):771-84.
2010: Barbara Renga; Andrea Mencarelli; Piero Vavassori; Vincenzo Brancaleone; Stefano Fiorucci
The bile acid sensor FXR regulates insulin transcription and secretion.
Biochimica et biophysica acta 2010;1802(3):363-72.
2010: Andrea Mencarelli; Sabrina Cipriani; Barbara Renga; Daniela Francisci; Giuseppe Palladino; Eleonora Distrutti; Franco Baldelli; Stefano Fiorucci
The bile acid sensor FXR protects against dyslipidemia and aortic plaques development induced by the HIV protease inhibitor ritonavir in mice.
PloS one 2010;5(10):e13238.
2010: P Prontera; B Buldrini; V Aiello; D Rogaia; Andrea Mencarelli; R Gruppioni; A Bonfatti; N Beltrami; Emilio Donti; A Sensi
Familial pericentric inversion of chromosome 18: intrafamilial variability of the recombinant dup(18q).
Genetic counseling (Geneva, Switzerland) 2010;21(1):91-7.
2010: Andrea Mencarelli; Stefano Fiorucci
FXR an emerging therapeutic target for the treatment of atherosclerosis.
Journal of cellular and molecular medicine 2010;14(1-2):79-92.
2010: Stefano Fiorucci; Andrea Mencarelli; Elenora Distrutti; Giuseppe Palladino; Sabrina Cipriani
Targetting farnesoid-X-receptor: from medicinal chemistry to disease treatment.
Current medicinal chemistry 2010;17(2):139-59.
2009: Andrea Mencarelli; Barbara Renga; Marco Migliorati; Sabrina Cipriani; Eleonora Distrutti; Luca Santucci; Stefano Fiorucci
The bile acid sensor farnesoid X receptor is a modulator of liver immunity in a rodent model of acute hepatitis.
Journal of immunology (Baltimore, Md. : 1950) 2009;183(10):6657-66.
2009: Piero Vavassori; Andrea Mencarelli; Barbara Renga; Eleonora Distrutti; Stefano Fiorucci
The bile acid receptor FXR is a modulator of intestinal innate immunity.
Journal of immunology (Baltimore, Md. : 1950) 2009;183(10):6251-61.
2009: Stefano Fiorucci; Andrea Mencarelli; Giuseppe Palladino; Sabrina Cipriani
Bile-acid-activated receptors: targeting TGR5 and farnesoid-X-receptor in lipid and glucose disorders.
Trends in pharmacological sciences 2009;30(11):570-80.
2009: Andrea Mencarelli; Barbara Renga; Giuseppe Palladino; Eleonora Distrutti; Stefano Fiorucci
The plant sterol guggulsterone attenuates inflammation and immune dysfunction in murine models of inflammatory bowel disease.
Biochemical pharmacology 2009;78(9):1214-23.
2009: Barbara Renga; Marco Migliorati; Andrea Mencarelli; Stefano Fiorucci
Reciprocal regulation of the bile acid-activated receptor FXR and the interferon-gamma-STAT-1 pathway in macrophages.
Biochimica et biophysica acta 2009;1792(6):564-73.
2009: Barbara Renga; Andrea Mencarelli; Marco Migliorati; Eleonora Distrutti; Stefano Fiorucci
Bile-acid-activated farnesoid X receptor regulates hydrogen sulfide production and hepatic microcirculation.
World journal of gastroenterology : WJG 2009;15(17):2097-108.
2008: Eleonora Distrutti; Andrea Mencarelli; Luca Santucci; Barbara Renga; Stefano Orlandi; Annibale Donini; Vijay Shah; Stefano Fiorucci
The methionine connection: homocysteine and hydrogen sulfide exert opposite effects on hepatic microcirculation in rats.
Hepatology (Baltimore, Md.) 2008;47(2):659-67.
2007: Luca Santucci; Andrea Mencarelli; Barbara Renga; Daniela Ceccobelli; Gianfranco Pasut; Francesco M Veronese; Eleonora Distrutti; Stefano Fiorucci
Cardiac safety and antitumoral activity of a new nitric oxide derivative of pegylated epirubicin in mice.
Anti-cancer drugs 2007;18(9):1081-91.
2007: Stefano Fiorucci; Stefano Orlandi; Andrea Mencarelli; Giuseppe Caliendo; Vincenzo Santagada; Eleonora Distrutti; Luca Santucci; Giuseppe Cirino; John L Wallace
Enhanced activity of a hydrogen sulphide-releasing derivative of mesalamine (ATB-429) in a mouse model of colitis.
British journal of pharmacology 2007;150(8):996-1002.
2007: Luca Santucci; Massimiliano Agostini; Stefano Bruscoli; Andrea Mencarelli; Simona Ronchetti; Emira Ayroldi; Antonio Morelli; Monia Baldoni; Carlo Riccardi
GITR modulates innate and adaptive mucosal immunity during the development of experimental colitis in mice.
Gut 2007;56(1):52-60.
2006: Eleonora Distrutti; Luca Sediari; Andrea Mencarelli; Barbara Renga; Stefano Orlandi; Giuseppe Russo; Giuseppe Caliendo; Vincenzo Santagada; Giuseppe Cirino; John L Wallace; Stefano Fiorucci
5-Amino-2-hydroxybenzoic acid 4-(5-thioxo-5H-[1,2]dithiol-3yl)-phenyl ester (ATB-429), a hydrogen sulfide-releasing derivative of mesalamine, exerts antinociceptive effects in a model of postinflammatory hypersensitivity.
The Journal of pharmacology and experimental therapeutics 2006;319(1):447-58.
2006: Giovanni Rizzo; Moises Disante; Andrea Mencarelli; Barbara Renga; Antimo Gioiello; Roberto Pellicciari; Stefano Fiorucci
The farnesoid X receptor promotes adipocyte differentiation and regulates adipose cell function in vivo.
Molecular pharmacology 2006;70(4):1164-73.
2006: Nathalie Vergnolle; Laurie Cellars; Andrea Mencarelli; Giovanni Rizzo; Sunita Swaminathan; Paul Beck; Martin Steinhoff; Patricia Andrade-Gordon; Nigel W Bunnett; Morley D Hollenberg; John L Wallace; Giuseppe Cirino; Stefano Fiorucci
A role for proteinase-activated receptor-1 in inflammatory bowel diseases.
The Journal of clinical investigation 2006;116(7):2056.
2006: Luca Santucci; Andrea Mencarelli; Barbara Renga; Gianfranco Pasut; Francesco M Veronese; Antonella Zacheo; Antonia Germani; Stefano Fiorucci
Nitric oxide modulates proapoptotic and antiapoptotic properties of chemotherapy agents: the case of NO-pegylated epirubicin.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2006;20(6):765-7.
2006: Eleonora Distrutti; Luca Sediari; Andrea Mencarelli; Barbara Renga; Stefano Orlandi; Elisabetta Antonelli; Fiorenza Roviezzo; Antonio Morelli; Giuseppe Cirino; John L Wallace; Stefano Fiorucci
Evidence that hydrogen sulfide exerts antinociceptive effects in the gastrointestinal tract by activating KATP channels.
The Journal of pharmacology and experimental therapeutics 2006;316(1):325-35.
2005: Stefano Fiorucci; Elisabetta Antonelli; Eleonora Distrutti; Giovanni Rizzo; Andrea Mencarelli; Stefano Orlandi; Renata C O Zanardo; Barbara Renga; Moses Di Sante; Antonio Morelli; Giuseppe Cirino; John L Wallace
Inhibition of hydrogen sulfide generation contributes to gastric injury caused by anti-inflammatory nonsteroidal drugs.
Gastroenterology 2005;129(4):1210-24.
2005: Stefano Fiorucci; Giovanni Rizzo; Elisabetta Antonelli; Barbara Renga; Andrea Mencarelli; Luisa Riccardi; Antonio Morelli; Mark Pruzanski; Roberto Pellicciari
Cross-talk between farnesoid-X-receptor (FXR) and peroxisome proliferator-activated receptor gamma contributes to the antifibrotic activity of FXR ligands in rodent models of liver cirrhosis.
The Journal of pharmacology and experimental therapeutics 2005;315(1):58-68.
2005: Giovanni Rizzo; Barbara Renga; Andrea Mencarelli; Roberto Pellicciari; Stefano Fiorucci
Role of FXR in regulating bile acid homeostasis and relevance for human diseases.
Current drug targets. Immune, endocrine and metabolic disorders 2005;5(3):289-303.
2005: Stefano Fiorucci; Elisabetta Antonelli; Andrea Mencarelli; Stefano Orlandi; Barbara Renga; Giovanni Rizzo; Eleonora Distrutti; Vijay Shah; Antonio Morelli
The third gas: H2S regulates perfusion pressure in both the isolated and perfused normal rat liver and in cirrhosis.
Hepatology (Baltimore, Md.) 2005;42(3):539-48.
2005: Stefano Fiorucci; Giovanni Rizzo; Elisabetta Antonelli; Barbara Renga; Andrea Mencarelli; Luisa Riccardi; Stefano Orlandi; Mark Pruzanski; Antonio Morelli; Roberto Pellicciari
A farnesoid x receptor-small heterodimer partner regulatory cascade modulates tissue metalloproteinase inhibitor-1 and matrix metalloprotease expression in hepatic stellate cells and promotes resolution of liver fibrosis.
The Journal of pharmacology and experimental therapeutics 2005;314(2):584-95.
2005: Luca Santucci; John Wallace; Andrea Mencarelli; Silvana Farneti; Antonio Morelli; Stefano Fiorucci
Different sensitivity of lamina propria T-cell subsets to nitric oxide-induced apoptosis explains immunomodulatory activity of a nitric oxide-releasing derivative of mesalamine in rodent colitis.
Gastroenterology 2005;128(5):1243-57.
2004: Stefano Fiorucci; John L Wallace; Andrea Mencarelli; Eleonora Distrutti; Giovanni Rizzo; Silvana Farneti; Antonio Morelli; Jih-Lie Tseng; Babu Suramanyam; William J Guilford; John Parkinson
A beta-oxidation-resistant lipoxin A4 analog treats hapten-induced colitis by attenuating inflammation and immune dysfunction.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(44):15736-41.
2004: Nathalie Vergnolle; Laurie Cellars; Andrea Mencarelli; Giovanni Rizzo; Sunita Swaminathan; Paul Beck; Martin Steinhoff; Patricia Andrade-Gordon; Nigel W Bunnett; Morley D Hollenberg; John L Wallace; Giuseppe Cirino; Stefano Fiorucci
A role for proteinase-activated receptor-1 in inflammatory bowel diseases.
The Journal of clinical investigation 2004;114(10):1444-56.
2004: Stefano Fiorucci; Elisabetta Antonelli; Giovanni Rizzo; Barbara Renga; Andrea Mencarelli; Luisa Riccardi; Stefano Orlandi; Roberto Pellicciari; Antonio Morelli
The nuclear receptor SHP mediates inhibition of hepatic stellate cells by FXR and protects against liver fibrosis.
Gastroenterology 2004;127(5):1497-512.
2004: Stefano Fiorucci; Elisabetta Antonelli; Eleonora Distrutti; Andrea Mencarelli; Silvana Farneti; Piero Del Soldato; Antonio Morelli
Liver delivery of NO by NCX-1000 protects against acute liver failure and mitochondrial dysfunction induced by APAP in mice.
British journal of pharmacology 2004;143(1):33-42.
2004: Stefano Fiorucci; Andrea Mencarelli; Alessandra Meneguzzi; Alessandro Lechi; Barbara Renga; Piero Del Soldato; Antonio Morelli; Pietro Minuz
Co-administration of nitric oxide-aspirin (NCX-4016) and aspirin prevents platelet and monocyte activation and protects against gastric damage induced by aspirin in humans.
Journal of the American College of Cardiology 2004;44(3):635-41.
2004: Stefano Fiorucci; Andrea Mencarelli; Eleonora Distrutti; Monia Baldoni; Piero Del Soldato; Antonio Morelli
Nitric oxide regulates immune cell bioenergetic: a mechanism to understand immunomodulatory functions of nitric oxide-releasing anti-inflammatory drugs.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(2):874-82.
2004: Stefano Fiorucci; Eleonora Distrutti; Andrea Mencarelli; Giovanni Rizzo; Anna Rita Di Lorenzo; Monia Baldoni; Piero Del Soldato; Antonio Morelli; John L Wallace
Cooperation between aspirin-triggered lipoxin and nitric oxide (NO) mediates antiadhesive properties of 2-(Acetyloxy)benzoic acid 3-(nitrooxymethyl)phenyl ester (NCX-4016) (NO-aspirin) on neutrophil-endothelial cell adherence.
The Journal of pharmacology and experimental therapeutics 2004;309(3):1174-82.
2004: John L Wallace; Stella R Zamuner; Webb McKnight; Michael Dicay; Andrea Mencarelli; Piero Del Soldato; Stefano Fiorucci
Aspirin, but not NO-releasing aspirin (NCX-4016), interacts with selective COX-2 inhibitors to aggravate gastric damage and inflammation.
American journal of physiology. Gastrointestinal and liver physiology 2004;286(1):G76-81.
2003: Stefano Fiorucci; Eleonora Distrutti; Andrea Mencarelli; Antonio Morelli; Stefan A Laufor; Giuseppe Cirino; John L Wallace
Evidence that 5-lipoxygenase and acetylated cyclooxygenase 2-derived eicosanoids regulate leukocyte-endothelial adherence in response to aspirin.
British journal of pharmacology 2003;139(7):1351-9.
2003: Stefano Fiorucci; Eleonora Distrutti; Octavio Menezes de Lima; Mario Romano; Andrea Mencarelli; Miriam Barbanti; Ernesto Palazzini; Antonio Morelli; John L Wallace
Relative contribution of acetylated cyclo-oxygenase (COX)-2 and 5-lipooxygenase (LOX) in regulating gastric mucosal integrity and adaptation to aspirin.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2003;17(9):1171-3.
2003: Luca Santucci; Stefano Fiorucci; Natalia Rubinstein; Andrea Mencarelli; Barbara Palazzetti; Barbara Federici; Gabriel A Rabinovich; Antonio Morelli
Galectin-1 suppresses experimental colitis in mice.
Gastroenterology 2003;124(5):1381-94.
2002: Stefano Fiorucci; Andrea Mencarelli; Alessandra Meneguzzi; Alessandro Lechi; Antonio Morelli; Piero Del Soldato; Pietro Minuz
NCX-4016 (NO-aspirin) inhibits lipopolysaccharide-induced tissue factor expression in vivo: role of nitric oxide.
Circulation 2002;106(24):3120-5.
2002: Stefano Fiorucci; Andrea Mencarelli; Barbara Palazzetti; Andrew G Sprague; Eleonora Distrutti; Antonio Morelli; Tatiana I Novobrantseva; Giuseppe Cirino; Victor E Koteliansky; Antonin R de Fougerolles
Importance of innate immunity and collagen binding integrin alpha1beta1 in TNBS-induced colitis.
Immunity 2002;17(6):769-80.
2002: Stefano Fiorucci; Octavio Menezes de Lima; Andrea Mencarelli; Barbara Palazzetti; Eleonora Distrutti; Webb McKnight; Michael Dicay; Li Ma; Mario Romano; Antonio Morelli; John L Wallace
Cyclooxygenase-2-derived lipoxin A4 increases gastric resistance to aspirin-induced damage.
Gastroenterology 2002;123(5):1598-606.
2002: Stefano Fiorucci; Andrea Mencarelli; Roberta Mannucci; Eleonora Distrutti; Antonio Morelli; Piero Del Soldato; Salvador Moncada
NCX-4016, a nitric oxide-releasing aspirin, protects endothelial cells against apoptosis by modulating mitochondrial function.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2002;16(12):1645-7.
2002: Stefano Fiorucci; Elisabetta Antonelli; Andrea Mencarelli; Barbara Palazzetti; Lorena Alvarez-Miller; Marcelo N Muscara; Piero Del Soldato; Laura Sanpaolo; John L Wallace; Antonio Morelli
A NO-releasing derivative of acetaminophen spares the liver by acting at several checkpoints in the Fas pathway.
British journal of pharmacology 2002;135(3):589-99.
2002: Stefano Fiorucci; Eleonora Distrutti; Andrea Mencarelli; Miriam Barbanti; Ernesto Palazzini; Antonio Morelli
Inhibition of intestinal bacterial translocation with rifaximin modulates lamina propria monocytic cells reactivity and protects against inflammation in a rodent model of colitis.
Digestion 2002;66(4):246-56.
2001: Stefano Fiorucci; Andrea Mencarelli; Barbara Palazzetti; Eleonora Distrutti; Nathalie Vergnolle; M D Hollenberg; John L Wallace; Antonio Morelli; Giuseppe Cirino
Proteinase-activated receptor 2 is an anti-inflammatory signal for colonic lamina propria lymphocytes in a mouse model of colitis.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(24):13936-41.
2001: Stefano Fiorucci; Eleonora Distrutti; M N Ajuebor; Andrea Mencarelli; Roberta Mannucci; Barbara Palazzetti; Piero Del Soldato; Antonio Morelli; John L Wallace
NO-mesalamine protects colonic epithelial cells against apoptotic damage induced by proinflammatory cytokines.
American journal of physiology. Gastrointestinal and liver physiology 2001;281(3):G654-65.
2001: Stefano Fiorucci; Elisabetta Antonelli; Olivia Morelli; Andrea Mencarelli; A Casini; Tommaso Mello; Barbara Palazzetti; Dominique Tallet; Piero Del Soldato; Antonio Morelli
NCX-1000, a NO-releasing derivative of ursodeoxycholic acid, selectively delivers NO to the liver and protects against development of portal hypertension.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(15):8897-902.
2001: Stefano Fiorucci; Andrea Mencarelli; Barbara Palazzetti; Piero Del Soldato; Antonio Morelli; Louis J Ignarro
An NO derivative of ursodeoxycholic acid protects against Fas-mediated liver injury by inhibiting caspase activity.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(5):2652-7.
2000: Stefano Fiorucci; Luca Santucci; Giuseppe Cirino; Andrea Mencarelli; Luigi Familiari; Piero Del Soldato; Antonio Morelli
IL-1 beta converting enzyme is a target for nitric oxide-releasing aspirin: new insights in the antiinflammatory mechanism of nitric oxide-releasing nonsteroidal antiinflammatory drugs.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(9):5245-54.
1999: Concetta Liberatore; Marusca Capanni; N Albi; I Volpi; Elena Urbani; Loredana Ruggeri; Andrea Mencarelli; Francesco Grignani; Andrea Velardi
Natural killer cell-mediated lysis of autologous cells modified by gene therapy.
The Journal of experimental medicine 1999;189(12):1855-62.
1998: Marta Fagioli; Myriam Alcalay; L Tomassoni; Pier Francesco Ferrucci; Andrea Mencarelli; Daniela Riganelli; Francesco Grignani; T Pozzan; Ildo Nicoletti; F Grignani; Pier Giuseppe Pelicci
Cooperation between the RING + B1-B2 and coiled-coil domains of PML is necessary for its effects on cell survival.
Oncogene 1998;16(22):2905-13.
1998: Francesco Grignani; T Kinsella; Andrea Mencarelli; Mauro Valtieri; Daniela Riganelli; F Grignani; L Lanfrancone; Cesare Peschle; G P Nolan; Pier Giuseppe Pelicci
High-efficiency gene transfer and selection of human hematopoietic progenitor cells with a hybrid EBV/retroviral vector expressing the green fluorescence protein.
Cancer research 1998;58(1):14-9.
1996: M Gambacorta; L Flenghi; Marta Fagioli; S Pileri; Lorenzo Leoncini; B Bigerna; R Pacini; L N Tanci; Laura Pasqualucci; Stefano Ascani; Andrea Mencarelli; Arcangelo Liso; Pier Giuseppe Pelicci; Brunangelo Falini
Heterogeneous nuclear expression of the promyelocytic leukemia (PML) protein in normal and neoplastic human tissues.
The American journal of pathology 1996;149(6):2023-35.
1996: Adelmo Terenzi; Franco Aversa; Andrea Mencarelli; Pier Giuseppe Pelicci; Andrea Velardi; Katia Perruccio; Massimo F Martelli
Unusual split chimaerism after mismatched T-depleted BMT.
Bone marrow transplantation 1996;18(2):465-7.
1994: Marta Fagioli; F Grignani; Pier Francesco Ferrucci; Myriam Alcalay; Andrea Mencarelli; Ildo Nicoletti; Francesco Grignani; Pier Giuseppe Pelicci
Effect of the acute promyelocytic leukemia PML/RAR alpha protein on differentiation and survival of myeloid precursors.
Leukemia 1994;8 Suppl 1():S7-11.
1993: Francesco Grignani; Pier Francesco Ferrucci; Ugo Testa; G Talamo; Marta Fagioli; Myriam Alcalay; Andrea Mencarelli; F Grignani; Cesare Peschle; Ildo Nicoletti
The acute promyelocytic leukemia-specific PML-RAR alpha fusion protein inhibits differentiation and promotes survival of myeloid precursor cells.
Cell 1993;74(3):423-31.
1992: Marta Fagioli; Myriam Alcalay; Pier Paolo Pandolfi; L Venturini; Andrea Mencarelli; A Simeone; D Acampora; Francesco Grignani; Pier Giuseppe Pelicci
Alternative splicing of PML transcripts predicts coexpression of several carboxy-terminally different protein isoforms.
Oncogene 1992;7(6):1083-91.
1992: Myriam Alcalay; D Zangrilli; Marta Fagioli; Pier Paolo Pandolfi; Andrea Mencarelli; Francesco Lo Coco; Andrea Biondi; Francesco Grignani; Pier Giuseppe Pelicci
Expression pattern of the RAR alpha-PML fusion gene in acute promyelocytic leukemia.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(11):4840-4.
1992: Pier Paolo Pandolfi; Myriam Alcalay; Marta Fagioli; D Zangrilli; Andrea Mencarelli; Daniela Diverio; Andrea Biondi; Francesco Lo Coco; Alessandro Rambaldi; Francesco Grignani
Genomic variability and alternative splicing generate multiple PML/RAR alpha transcripts that encode aberrant PML proteins and PML/RAR alpha isoforms in acute promyelocytic leukaemia.
The EMBO journal 1992;11(4):1397-407.
1991: Pier Paolo Pandolfi; Francesco Grignani; Myriam Alcalay; Andrea Mencarelli; Andrea Biondi; F LoCoco; F Grignani; Pier Giuseppe Pelicci
Structure and origin of the acute promyelocytic leukemia myl/RAR alpha cDNA and characterization of its retinoid-binding and transactivation properties.
Oncogene 1991;6(7):1285-92.
1991: Andrea Biondi; Alessandro Rambaldi; Myriam Alcalay; Pier Paolo Pandolfi; Francesco Lo Coco; Daniela Diverio; V Rossi; Andrea Mencarelli; L Longo; D Zangrilli
RAR-alpha gene rearrangements as a genetic marker for diagnosis and monitoring in acute promyelocytic leukemia.
Blood 1991;77(7):1418-22.
1991: Myriam Alcalay; D Zangrilli; Pier Paolo Pandolfi; L Longo; Andrea Mencarelli; A Giacomucci; M Rocchi; Andrea Biondi; Alessandro Rambaldi; Francesco Lo Coco
Translocation breakpoint of acute promyelocytic leukemia lies within the retinoic acid receptor alpha locus.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(5):1977-81.
1991: Franco Aversa; Pier Giuseppe Pelicci; Adelmo Terenzi; Alessandra Carotti; Rita Felicini; Andrea Mencarelli; Emilio Donti; Paolo Latini; Cynthia Aristei; Massimo F Martelli
Results of T-depleted BMT in chronic myelogenous leukaemia after a conditioning regimen that included thiotepa.
Bone marrow transplantation 1991;7 Suppl 2():24.
1990: L Longo; Pier Paolo Pandolfi; Andrea Biondi; Alessandro Rambaldi; Andrea Mencarelli; Francesco Lo Coco; Daniela Diverio; Luigi Pegoraro; G Avanzi; Antonio Tabilio
Rearrangements and aberrant expression of the retinoic acid receptor alpha gene in acute promyelocytic leukemias.
The Journal of experimental medicine 1990;172(6):1571-5.
1990: L Longo; Emilio Donti; Andrea Mencarelli; G Avanzi; Luigi Pegoraro; G Alimena; Antonio Tabilio; Giovanna Venti; Francesco Grignani; Pier Giuseppe Pelicci
Mapping of chromosome 17 breakpoints in acute myeloid leukemias.
Oncogene 1990;5(10):1557-63.