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Stephen Baylin

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Nilofer Azad; Charles M Rudin; Cynthia A Zahnow; Stephen B Baylin
The future of epigenetic therapy in solid tumours-lessons from the past.
Kurinji Pandiyan; Xiaojing Yang; Jueng-Soo You; Xianghong J Zhou; Stephen B Baylin; Chao Dai; Peter A Jones; Gangning Liang
Functional DNA demethylation is accompanied by chromatin accessibility.
Hariharan Easwaran; Stephen B Baylin
Epigenetic abnormalities in cancer find a "home on the range".

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All Publications

2013: Nilofer Azad; Charles M Rudin; Cynthia A Zahnow; Stephen B Baylin
The future of epigenetic therapy in solid tumours-lessons from the past.
Nature reviews. Clinical oncology 2013;10(5):256-66.
2013: Kurinji Pandiyan; Xiaojing Yang; Jueng-Soo You; Xianghong J Zhou; Stephen B Baylin; Chao Dai; Peter A Jones; Gangning Liang
Functional DNA demethylation is accompanied by chromatin accessibility.
Nucleic acids research 2013;41(7):3973-85.
2013: Hariharan Easwaran; Stephen B Baylin
Epigenetic abnormalities in cancer find a "home on the range".
Cancer cell 2013;23(1):1-3.
2012: Tao Fu; Angela A Guzzetta; Craig M Hooker; Christine A Iacobuzio-Donahue; Jana Jeschke; Ruby Kwak; Richard Morgan; Emmanouil P Pappou; Christopher L Wolfgang; Stephen B Baylin; Pujan Dave; NITA AHUJA
CpG island methylator phenotype-positive tumors in the absence of MLH1 methylation constitute a distinct subset of duodenal adenocarcinomas and are associated with poor prognosis.
Clinical cancer research : an official journal of the American Association for Cancer Research 2012;18(17):4743-52.
2012: Jana Jeschke; Alexander Koch; Kornel E Schuebel; Wim van Criekinge; Leander Van Neste; Ilse Vlassenbroeck; Andreas Winterpacht; Stephen B Baylin; Marilia Freitas Calmon; Timothy A Chan; Leslie Cope; Valérie Deregowski; Mashaal Dhir; Edward Gabrielson; Sabine C Glöckner; James G Herman; Craig M Hooker; NITA AHUJA
Biomarkers for detection and prognosis of breast cancer identified by a functional hypermethylome screen.
Epigenetics : official journal of the DNA Methylation Society 2012;7(7):701-9.
2012: Shuguang Leng; Maria A Picchi; Christine A Stidley; Holly J Wolf; Christin M Yingling; Malcolm V Brock; Tim Byers; Kieu Do; William J Feser; Wilbur A Franklin; James G Herman; Timothy C Kennedy; Anna E Baron; Stephen B Baylin; Steven A Belinsky
Defining a gene promoter methylation signature in sputum for lung cancer risk assessment.
Clinical cancer research : an official journal of the American Association for Cancer Research 2012;18(12):3387-95.
2012: Stephen B Baylin
The cancer epigenome: its origins, contributions to tumorigenesis, and translational implications.
Proceedings of the American Thoracic Society 2012;9(2):64-5.
2012: Hariharan Easwaran; Sarah E Johnstone; Patrick Joyce; William Matsui; Tim Mosbruger; Joyce E Ohm; Leander Van Neste; Qiuju Wang; Dan Weisenberger; Srinivasan Yegnasubramanian; Jingchun Zhu; NITA AHUJA; Martin Aryee; Eric Collisson; Stephen B Baylin
A DNA hypermethylation module for the stem/progenitor cell signature of cancer.
Genome research 2012;22(5):837-49.
2012: Eriko G Clements; Hariharan Easwaran; Benjamin R Leadem; Helai P Mohammad; Leander Van Neste; Yi Cai; Stephen B Baylin
DNMT1 modulates gene expression without its catalytic activity partially through its interactions with histone-modifying enzymes.
Nucleic acids research 2012;40(10):4334-46.
2012: Hariharan Easwaran; Stephen B Baylin
Biomarkers for EGFR-antagonist response: in the genes and on the genes!
Clinical cancer research : an official journal of the American Association for Cancer Research 2012;18(8):2121-3.
2012: Hsing-Chen Tsai; Leander Van Neste; Alana L Welm; Lonny Brett Yarmus; Ray-Whay Chiu Yen; NITA AHUJA; Stephen B Baylin; ROBERT BEATY; Malcolm V Brock; Yi Cai; DAVID FELLER-KOPMAN; Kirsten M Harbom; James Harris; Jean-Pierre J Issa; YOON YOUNG JANG; Huili Li; Yi-Chun Lin; William Matsui; Il Minn; Emmanouil Pappou; Feyruz V Rassool; Carine Robert; Saul J Sharkis; James J Shin; Vered Stearns; Cynthia A Zahnow
Transient low doses of DNA-demethylating agents exert durable antitumor effects on hematological and epithelial tumor cells.
Cancer cell 2012;21(3):430-46.
2012: Timothy A Chan; Stephen B Baylin
Epigenetic biomarkers.
Current topics in microbiology and immunology 2012;355():189-216.
2011: Rosalyn A Juergens; Beverly Lee; Sara C Murphy; Kristen Rodgers; Michelle A Rudek; Rosa Sebree; Salina D Tsai; Frank P Vendetti; John Wrangle; Ming Zhao; Stephen B Baylin; Steven A Belinsky; Malcolm V Brock; Barbara Coleman; Igor Espinoza Delgado; Noreli Franco; James G Herman; Craig M Hooker; Charles Rudin
Combination epigenetic therapy has efficacy in patients with refractory advanced non-small cell lung cancer.
Cancer discovery 2011;1(7):598-607.
2011: Heather M O'Hagan; Cynthia L Sears; Subhojit Sen; Leander Van Neste; Wei Wang; Yang W Zhang; Yi Cai; Robert A Casero; Eriko G Clements; Christina Destefano Shields; Hariharan Easwaran; Stella S Lee; Stephen B Baylin
Oxidative damage targets complexes containing DNA methyltransferases, SIRT1, and polycomb members to promoter CpG Islands.
Cancer cell 2011;20(5):606-19.
2011: James E Harris; Craig M Hooker; Alicia Hulbert; Beverly Lee; Kristen Pelosky; James Shin; Stephen C Yang; Cynthia A Zahnow; Stephen B Baylin; CORY BRAYTON; Kirsten Harbom; Malcolm V Brock
A murine xenograft model of spontaneous metastases of human lung adenocarcinoma.
The Journal of surgical research 2011;171(1):e75-9.
2011: Mashaal Dhir; Sabine C Glöckner; James G Herman; Christine A Iacobuzio-Donahue; Jana Jeschke; Elizabeth Montgomery; Emmanouil P Pappou; Shinichi Yachida; Leander Van Neste; Stephen B Baylin; NITA AHUJA
Sessile serrated adenomas and classical adenomas: an epigenetic perspective on premalignant neoplastic lesions of the gastrointestinal tract.
International journal of cancer. Journal international du cancer 2011;129(8):1889-98.
2011: Stephen B Baylin; Peter A Jones
A decade of exploring the cancer epigenome - biological and translational implications.
Nature reviews. Cancer 2011;11(10):726-34.
2011: Stephen B Baylin; Peter Jones
Q&A: Stephen Baylin and Peter Jones on team science by Suzanne Rose.
Cancer discovery 2011;1(4):279.
2011: Jinshui Fan; YOON YOUNG JANG; Hua Liu; Carine Robert; Saul J Sharkis; Stephen B Baylin; Feyruz V Rassool
Human induced pluripotent cells resemble embryonic stem cells demonstrating enhanced levels of DNA repair and efficacy of nonhomologous end-joining.
Mutation research 2011;713(1-2):8-17.
2011: Helai P Mohammad; H S Prevas; DAVID WATKINS; M Zhang; W Zhang; James G Herman; Craig M Hooker; David L Huso; Baktiar O Karim; B R Leadem; Stephen B Baylin
Loss of a single Hic1 allele accelerates polyp formation in Apc(Δ716) mice.
Oncogene 2011;30(23):2659-69.
2011: Eitan Halper-Stromberg; Laurence Frelin; Ingo Ruczinski; Robert B Scharpf; Chunfa Jie; Benilton Carvalho; Haiping Hao; Kurt Hetrick; Anne E Jedlicka; Amanda Dziedzic; Kim Doheny; Alan F Scott; Stephen B Baylin; Jonathan Pevsner; Forrest Spencer; Rafael A Irizarry
Performance assessment of copy number microarray platforms using a spike-in experiment.
Bioinformatics (Oxford, England) 2011;27(8):1052-60.
2011: Fang Fang; Sevin Turcan; Andreas Rimner; Andrew Kaufman; Dilip Giri; Luc G T Morris; Ronglai Shen; Venkatraman Seshan; Qianxing Mo; Adriana Heguy; Stephen B Baylin; NITA AHUJA; Agnes Viale; Joan Massague; Larry Norton; Linda Vahdat; Mary Ellen Moynahan; Timothy Chan
Breast cancer methylomes establish an epigenomic foundation for metastasis.
Science translational medicine 2011;3(75):75ra25.
2011: Joo-Mi Yi; Mashaal Dhir; Leander Van Neste; Stephanie R Downing; Jana Jeschke; Sabine C Glöckner; Marilia de Freitas Calmon; Craig M Hooker; Juan M Funes; Chris Boshoff; Kim M Smits; Manon van Engeland; Matty P Weijenberg; Christine A Iacobuzio-Donahue; James G Herman; Kornel E Schuebel; Stephen B Baylin; NITA AHUJA
Genomic and epigenomic integration identifies a prognostic signature in colon cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2011;17(6):1535-45.
2011: Stephen B Baylin
Resistance, epigenetics and the cancer ecosystem.
Nature medicine 2011;17(3):288-9.
2011: Hsing-Chen Tsai; Stephen B Baylin
Cancer epigenetics: linking basic biology to clinical medicine.
Cell research 2011;21(3):502-17.
2011: Steven A Belinsky; Marcie J Grimes; Maria A Picchi; Hugh D Mitchell; Christine A Stidley; Stephanie Holmgren; Meghan M Channell; Yanbin Liu; Robert A Casero; Stephen B Baylin; Mathew D Reed; Carmen S Tellez; Thomas H March
Combination therapy with vidaza and entinostat suppresses tumor growth and reprograms the epigenome in an orthotopic lung cancer model.
Cancer research 2011;71(2):454-62.
2010: J D F Licchesi; L Van Neste; V K Tiwari; Leslie Cope; X Lin; Stephen B Baylin; James G Herman
Transcriptional regulation of Wnt inhibitory factor-1 by Miz-1/c-Myc.
Oncogene 2010;29(44):5923-34.
2010: Sarah E Johnstone; Stephen B Baylin
Stress and the epigenetic landscape: a link to the pathobiology of human diseases?
Nature reviews. Genetics 2010;11(11):806-12.
2010: Hariharan P Easwaran; Leander Van Neste; Leslie Cope; Subhojit Sen; Helai P Mohammad; Gayle J Pageau; Jeanne B Lawrence; James G Herman; Kornel E Schuebel; Stephen B Baylin
Aberrant silencing of cancer-related genes by CpG hypermethylation occurs independently of their spatial organization in the nucleus.
Cancer research 2010;70(20):8015-24.
2010: Helai P Mohammad; Stephen B Baylin
Linking cell signaling and the epigenetic machinery.
Nature biotechnology 2010;28(10):1033-8.
2010: Joyce E Ohm; Prashant Mali; Leander Van Neste; berman david; Liang Liang; Kurinji Pandiyan; Kimberly J Briggs; Wei Zhang; Pedram Argani; Brian Simons; Wayne Yu; William Matsui; Wim van Criekinge; Feyruz V Rassool; ELIAS ZAMBIDIS; Kornel E Schuebel; Leslie Cope; Jonathan Yen; Helai P Mohammad; Linzhao Cheng; Stephen B Baylin
Cancer-related epigenome changes associated with reprogramming to induced pluripotent stem cells.
Cancer research 2010;70(19):7662-73.
2010: Cynthia A Zahnow; Stephen B Baylin
Epigenetic networks and miRNAs in stem cells and cancer.
Molecular cell 2010;39(5):661-3.
2010: Vasudev J Bailey; Yi Zhang; Brian P Keeley; Chao Yin; Kristen L Pelosky; Malcolm V Brock; Stephen B Baylin; James G Herman; Tza-Huei Wang
Single-tube analysis of DNA methylation with silica superparamagnetic beads.
Clinical chemistry 2010;56(6):1022-5.
2010: Houtan Noushmehr; Daniel J Weisenberger; Kristin Diefes; Heidi S Phillips; Kanan Pujara; Benjamin P Berman; Fei Pan; Christopher E Pelloski; Erik P Sulman; Krishna P Bhat; Roel G W Verhaak; Katherine A Hoadley; D Neil Hayes; Charles M Perou; Heather K Schmidt; Li Ding; Richard K Wilson; David Van Den Berg; Hui Shen; Henrik Bengtsson; Pierre Neuvial; Leslie Cope; Jonathan Buckley; James G Herman; Stephen B Baylin; Peter W Laird; Kenneth Aldape
Identification of a CpG island methylator phenotype that defines a distinct subgroup of glioma.
Cancer cell 2010;17(5):510-22.
2010: W Zhang; X Zeng; K J Briggs; ROBERT BEATY; B Simons; R-W Chiu Yen; M A Tyler; H-C Tsai; Y Ye; G S Gesell; James G Herman; Stephen B Baylin; DAVID WATKINS
A potential tumor suppressor role for Hic1 in breast cancer through transcriptional repression of ephrin-A1.
Oncogene 2010;29(17):2467-76.
2010: Prashant Mali; Bin-Kuan Chou; Jonathan Yen; Zhaohui Ye; Jizhong Zou; Sarah Dowey; Robert A Brodsky; Joyce E Ohm; Wayne Yu; Stephen B Baylin; Kosuke Yusa; Allan Bradley; DAVID MEYERS; Chandrani Mukherjee; Philip A Cole; Linzhao Cheng
Butyrate greatly enhances derivation of human induced pluripotent stem cells by promoting epigenetic remodeling and the expression of pluripotency-associated genes.
Stem cells (Dayton, Ohio) 2010;28(4):713-20.
2010: Vasudev J Bailey; Brian P Keeley; Yi Zhang; Yi-Ping Ho; Hariharan Easwaran; Malcolm V Brock; Kristen L Pelosky; Hetty Carraway; Stephen B Baylin; James G Herman; Tza-Huei Wang
Enzymatic incorporation of multiple dyes for increased sensitivity in QD-FRET sensing for DNA methylation detection.
Chembiochem : a European journal of chemical biology 2010;11(1):71-4.
2010: Hariharan P Easwaran; Stephen B Baylin
Role of nuclear architecture in epigenetic alterations in cancer.
Cold Spring Harbor symposia on quantitative biology 2010;75():507-15.
2010: Vijay K Tiwari; Stephen B Baylin
Mapping networks of protein-mediated physical interactions between chromatin elements.
Current protocols in molecular biology / edited by Frederick M. Ausubel ... [et al.] 2010;Chapter 21():Unit 21.16.1-13.
2009: Yi Huang; Tracy Murray-Stewart; Yu Wu; Stephen B Baylin; Laurence J Marton; Brandy Perkins; Richard J Jones; Patrick M Woster; Robert A Casero
Novel oligoamine analogues inhibit lysine-specific demethylase 1 and induce reexpression of epigenetically silenced genes.
Clinical cancer research : an official journal of the American Association for Cancer Research 2009;15(23):7217-28.
2009: Helai P Mohammad; Yi Cai; Kelly M McGarvey; Hariharan Easwaran; Leander Van Neste; Joyce E Ohm; Heather M O'Hagan; Stephen B Baylin
Polycomb CBX7 promotes initiation of heritable repression of genes frequently silenced with cancer-specific DNA hypermethylation.
Cancer research 2009;69(15):6322-30.
2009: Vasudev J Bailey; Hariharan Easwaran; Yi Zhang; Elizabeth Griffiths; Steven A Belinsky; James G Herman; Stephen B Baylin; Hetty Carraway; Tza-Huei Wang
MS-qFRET: a quantum dot-based method for analysis of DNA methylation.
Genome research 2009;19(8):1455-61.
2009: Mathewos Tessema; Yang Y Yu; Christine A Stidley; Emi O Machida; Kornel E Schuebel; Stephen B Baylin; Steven A Belinsky
Concomitant promoter methylation of multiple genes in lung adenocarcinomas from current, former and never smokers.
Carcinogenesis 2009;30(7):1132-8.
2009: Debby M E I Hellebrekers; Marjolein H F M Lentjes; Sandra M van den Bosch; Veerle Melotte; Kim A D Wouters; Kathleen L J Daenen; Kim M Smits; Yoshimitsu Akiyama; Yasuhito Yuasa; Silvia Sanduleanu; Carolina A J Khalid-de Bakker; Daisy Jonkers; Matty P Weijenberg; joost louwagie; Wim van Criekinge; Beatriz Carvalho; Gerrit A Meijer; Stephen B Baylin; James G Herman; Adriaan P de Bruïne; Manon van Engeland
GATA4 and GATA5 are potential tumor suppressors and biomarkers in colorectal cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2009;15(12):3990-7.
2009: Sabine C Glöckner; Mashaal Dhir; Joo-Mi Yi; Kelly E McGarvey; Leander Van Neste; joost louwagie; Timothy Chan; Wolfram Kleeberger; Adriaan P de Bruïne; Kim M Smits; Carolina A J Khalid-de Bakker; Daisy M A E Jonkers; Reinhold W Stockbrügger; Gerrit A Meijer; Frank A Oort; Christine A Iacobuzio-Donahue; Katja Bierau; James G Herman; Stephen B Baylin; Manon Van Engeland; Kornel E Schuebel; NITA AHUJA
Methylation of TFPI2 in stool DNA: a potential novel biomarker for the detection of colorectal cancer.
Cancer research 2009;69(11):4691-9.
2009: Vijay K Tiwari; Stephen B Baylin
Breaching the boundaries that safeguard against repression.
Molecular cell 2009;34(4):395-7.
2009: Yi Zhang; Vasudev Bailey; Christopher M Puleo; Hariharan Easwaran; Elizabeth Griffiths; James G Herman; Stephen B Baylin; Tza-Huei Wang
DNA methylation analysis on a droplet-in-oil PCR array.
Lab on a chip 2009;9(8):1059-64.
2009: Vijay K Tiwari; Stephen B Baylin
Combined 3C-ChIP-cloning (6C) assay: a tool to unravel protein-mediated genome architecture.
Cold Spring Harbor protocols 2009;2009(3):pdb.prot5168.
2008: Vijay K Tiwari; Kelly M McGarvey; Julien D F Licchesi; Joyce E Ohm; James G Herman; Dirk Schübeler; Stephen B Baylin
PcG proteins, DNA methylation, and gene repression by chromatin looping.
PLoS biology 2008;6(12):2911-27.
2008: Joo-Mi Yi; Hsing-Chen Tsai; Sabine C Glöckner; Steven Lin; Joyce E Ohm; Hari Easwaran; C David James; Joseph F Costello; Gregory J Riggins; Charles G Eberhart; John Laterra; Angelo L Vescovi; NITA AHUJA; James G Herman; Kornel E Schuebel; Stephen B Baylin
Abnormal DNA methylation of CD133 in colorectal and glioblastoma tumors.
Cancer research 2008;68(19):8094-103.
2008: Mashaal Dhir; Elizabeth Montgomery; Sabine C Glöckner; Kornel E Schuebel; Craig M Hooker; James G Herman; Stephen B Baylin; Susan L Gearhart; NITA AHUJA
Epigenetic regulation of WNT signaling pathway genes in inflammatory bowel disease (IBD) associated neoplasia.
Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract 2008;12(10):1745-53.
2008: Kelly M McGarvey; Leander Van Neste; Leslie Cope; Joyce E Ohm; James G Herman; Wim van Criekinge; Kornel E Schuebel; Stephen B Baylin
Defining a chromatin pattern that characterizes DNA-hypermethylated genes in colon cancer cells.
Cancer research 2008;68(14):5753-9.
2008: Vijay K Tiwari; Leslie Cope; Kelly M McGarvey; Joyce E Ohm; Stephen B Baylin
A novel 6C assay uncovers Polycomb-mediated higher order chromatin conformations.
Genome research 2008;18(7):1171-9.
2008: Anchalee Jiemjit; James G Herman; K A Bailey; Stephen B Baylin; Hetty Carraway; Tamer E Fandy; Steven D Gore
p21(WAF1/CIP1) induction by 5-azacytosine nucleosides requires DNA damage.
Oncogene 2008;27(25):3615-23.
2008: Timothy Chan; Sabine Glockner; Joo-Mi Yi; Wei Chen; Leander Van Neste; Leslie Cope; James G Herman; Victor E Velculescu; Kornel E Schuebel; NITA AHUJA; Stephen B Baylin
Convergence of mutation and epigenetic alterations identifies common genes in cancer that predict for poor prognosis.
PLoS medicine 2008;5(5):e114.
2008: Julien D F Licchesi; William H Westra; Craig M Hooker; Emi O Machida; Stephen B Baylin; James G Herman
Epigenetic alteration of Wnt pathway antagonists in progressive glandular neoplasia of the lung.
Carcinogenesis 2008;29(5):895-904.
2008: Wei Zhang; Sabine C Glöckner; Mingzhou Guo; Emi Ota Machida; David H Wang; Hariharan Easwaran; Leander Van Neste; James G Herman; Kornel E Schuebel; DAVID WATKINS; NITA AHUJA; Stephen B Baylin
Epigenetic inactivation of the canonical Wnt antagonist SRY-box containing gene 17 in colorectal cancer.
Cancer research 2008;68(8):2764-72.
2008: Angela H Ting; Hiromu Suzuki; Leslie Cope; Kornel E Schuebel; Byron H Lee; Minoru Toyota; Kohzoh Imai; Yasuhisa Shinomura; Takashi Tokino; Stephen B Baylin
A requirement for DICER to maintain full promoter CpG island hypermethylation in human cancer cells.
Cancer research 2008;68(8):2570-5.
2008: Hiromu Suzuki; Minoru Toyota; Hetty Carraway; H Caraway; Edward Gabrielson; T Ohmura; T Fujikane; Noriko Nishikawa; Y Sogabe; M Nojima; Tomoko Sonoda; M Mori; Koichi Hirata; Kohzoh Imai; Yasuhisa Shinomura; Stephen B Baylin; Takashi Tokino
Frequent epigenetic inactivation of Wnt antagonist genes in breast cancer.
British journal of cancer 2008;98(6):1147-56.
2008: Kimberly J Briggs; Ian M Corcoran-Schwartz; Wei Zhang; Thomas Harcke; Wendy L Devereux; Stephen B Baylin; Charles G Eberhart; DAVID WATKINS
Cooperation between the Hic1 and Ptch1 tumor suppressors in medulloblastoma.
Genes & development 2008;22(6):770-85.
2008: Mathewos Tessema; Randy Willink; Kieu Do; Yang Y Yu; Wayne Yu; Emi O Machida; Malcolm V Brock; Leander Van Neste; Christine A Stidley; Stephen B Baylin; Steven A Belinsky
Promoter methylation of genes in and around the candidate lung cancer susceptibility locus 6q23-25.
Cancer research 2008;68(6):1707-14.
2008: Malcolm V Brock; Craig M Hooker; Emi Ota-Machida; Yu Han; Mingzhou Guo; Stephen Ames; Sabine Glöckner; Steven Piantadosi; Edward Gabrielson; Genevieve Pridham; Kristen Pelosky; Steven A Belinsky; Stephen C Yang; Stephen B Baylin; James G Herman
DNA methylation markers and early recurrence in stage I lung cancer.
The New England journal of medicine 2008;358(11):1118-28.
2008: Jordan M Winter; Angela H Ting; Felip Vilardell; Eike Gallmeier; Stephen B Baylin; Ralph Hruban; Scott E Kern; Christine A Iacobuzio-Donahue
Absence of E-cadherin expression distinguishes noncohesive from cohesive pancreatic cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2008;14(2):412-8.
2008: Heather M O'Hagan; Helai P Mohammad; Stephen B Baylin
Double strand breaks can initiate gene silencing and SIRT1-dependent onset of DNA methylation in an exogenous promoter CpG island.
PLoS genetics 2008;4(8):e1000155.
2007: Marco A Riojas; Mingzhou Guo; Sabine C Glöckner; Emi Ota Machida; Stephen B Baylin; NITA AHUJA
Methylation-induced silencing of ASC/TMS1, a pro-apoptotic gene, is a late-stage event in colorectal cancer.
Cancer biology & therapy 2007;6(11):1710-6.
2007: Kornel E Schuebel; Wei Chen; Leslie Cope; Sabine C Glöckner; Hiromu Suzuki; Joo-Mi Yi; Timothy Chan; Leander Van Neste; Wim van Criekinge; Sandra van den Bosch; Manon van Engeland; Angela H Ting; Kam-Wing Jair; Wayne Yu; Minoru Toyota; Kohzoh Imai; NITA AHUJA; James G Herman; Stephen B Baylin
Comparing the DNA hypermethylome with gene mutations in human colorectal cancer.
PLoS genetics 2007;3(9):1709-23.
2007: Stephen B Baylin; Kornel E Schuebel
Genomic biology: the epigenomic era opens.
Nature 2007;448(7153):548-9.
2007: Kelly M McGarvey; Eriko Greene; Jill A Fahrner; Thomas Jenuwein; Stephen B Baylin
DNA methylation and complete transcriptional silencing of cancer genes persist after depletion of EZH2.
Cancer research 2007;67(11):5097-102.
2007: Yi Huang; Eriko Greene; Tracy Murray-Stewart; Andrew C Goodwin; Stephen B Baylin; Patrick M Woster; Robert A Casero
Inhibition of lysine-specific demethylase 1 by polyamine analogues results in reexpression of aberrantly silenced genes.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(19):8023-8.
2007: Joyce E Ohm; Stephen B Baylin
Stem cell chromatin patterns: an instructive mechanism for DNA hypermethylation?
Cell cycle (Georgetown, Tex.) 2007;6(9):1040-3.
2007: Sandra A Biankin; Michael I Collector; Andrew V Biankin; Lindsey J Brown; Wolfram Kleeberger; Wendy L Devereux; Cynthia A Zahnow; Stephen B Baylin; DAVID WATKINS; Saul J Sharkis; Steven D Leach
A histological survey of green fluorescent protein expression in 'green' mice: implications for stem cell research.
Pathology 2007;39(2):247-51.
2007: M Chris Gibbons; Malcolm V Brock; Anthony J Alberg; Thomas A. Glass; Thomas A LaVeist; Stephen B Baylin; David M Levine; Claude Earl Fox
The sociobiologic integrative model (SBIM): enhancing the integration of sociobehavioral, environmental, and biomolecular knowledge in urban health and disparities research.
Journal of urban health : bulletin of the New York Academy of Medicine 2007;84(2):198-211.
2007: Peter A Jones; Stephen B Baylin
The epigenomics of cancer.
Cell 2007;128(4):683-92.
2007: Joyce E Ohm; Kelly M McGarvey; Xiaobing Yu; Linzhao Cheng; Kornel E Schuebel; Leslie Cope; Helai P Mohammad; Wei Chen; Vincent C Daniel; Wayne Yu; berman david; Thomas Jenuwein; Kevin Pruitt; Saul J Sharkis; DAVID WATKINS; James G Herman; Stephen B Baylin
A stem cell-like chromatin pattern may predispose tumor suppressor genes to DNA hypermethylation and heritable silencing.
Nature genetics 2007;39(2):237-42.
2007: Malcolm V Brock; James G Herman; Stephen B Baylin
Cancer as a manifestation of aberrant chromatin structure.
Cancer journal (Sudbury, Mass.) 2007;13(1):3-8.
2007: Rebekah L Zinn; Kevin Pruitt; Sayaka Eguchi; Stephen B Baylin; James G Herman
hTERT is expressed in cancer cell lines despite promoter DNA methylation by preservation of unmethylated DNA and active chromatin around the transcription start site.
Cancer research 2007;67(1):194-201.
2006: Angela H Ting; Kelly M McGarvey; Stephen B Baylin
The cancer epigenome--components and functional correlates.
Genes & development 2006;20(23):3215-31.
2006: Mingzhou Guo; Michael G House; Yoshimitsu Akiyama; Yu Qi; Domenico Capagna; John W Harmon; Stephen B Baylin; Malcolm V Brock; James G Herman
Hypermethylation of the GATA gene family in esophageal cancer.
International journal of cancer. Journal international du cancer 2006;119(9):2078-83.
2006: Anju Singh; Vikas Misra; Rajesh K Thimmulappa; Hannah Lee; Stephen Ames; Mohammad Hoque; James G Herman; Stephen B Baylin; David Sidransky; Edward Gabrielson; Malcolm V Brock; Shyam Biswal
Dysfunctional KEAP1-NRF2 interaction in non-small-cell lung cancer.
PLoS medicine 2006;3(10):e420.
2006: Malcolm V Brock; Craig M Hooker; Eric A Engels; Richard D Moore; Maura L Gillison; Anthony J Alberg; Jeanne C Keruly; Stephen C Yang; Richard F Heitmiller; Stephen B Baylin; James G Herman; Julie R Brahmer
Delayed diagnosis and elevated mortality in an urban population with HIV and lung cancer: implications for patient care.
Journal of acquired immune deficiency syndromes (1999) 2006;43(1):47-55.
2006: Kornel E Schuebel; Wei Chen; Stephen B Baylin
CIMPle origin for promoter hypermethylation in colorectal cancer?
Nature genetics 2006;38(7):738-40.
2006: Steven D Gore; Stephen B Baylin; Elizabeth Sugar; Hetty Carraway; Carole B Miller; Michael A Carducci; Michael R Grever; Oliver Galm; Tianna Dauses; Judith E Karp; MICHELLE RUDEK-RENAUT; Ming Zhao; B Douglas Smith; Jasper Manning; Anchalee Jiemjit; George J Dover; Abbie Mays; James Zwiebel; Anthony J Murgo; Li-Jun Weng; James G Herman
Combined DNA methyltransferase and histone deacetylase inhibition in the treatment of myeloid neoplasms.
Cancer research 2006;66(12):6361-9.
2006: Emi Ota Machida; Malcolm V Brock; Craig M Hooker; Jun Nakayama; Akiko Ishida; Jun Amano; Maria A Picchi; Steven A Belinsky; James G Herman; Shun'ichiro Taniguchi; Stephen B Baylin
Hypermethylation of ASC/TMS1 is a sputum marker for late-stage lung cancer.
Cancer research 2006;66(12):6210-8.
2006: Xian-Zi Wen; Yoshimitsu Akiyama; Stephen B Baylin; Yasuhito Yuasa
Frequent epigenetic silencing of the bone morphogenetic protein 2 gene through methylation in gastric carcinomas.
Oncogene 2006;25(18):2666-73.
2006: Kelly M McGarvey; Jill A Fahrner; Eriko Greene; Joost Martens; Thomas Jenuwein; Stephen B Baylin
Silenced tumor suppressor genes reactivated by DNA demethylation do not return to a fully euchromatic chromatin state.
Cancer research 2006;66(7):3541-9.
2006: Steven A Belinsky; Kieu C Liechty; Frederick D Gentry; Holly J Wolf; Justin Rogers; Kieu O Vu; Jerry Haney; Timothy C Kennedy; Fred R Hirsch; York E Miller; Wilbur A Franklin; James G Herman; Stephen B Baylin; Paul A Bunn; Tim E Byers
Promoter hypermethylation of multiple genes in sputum precedes lung cancer incidence in a high-risk cohort.
Cancer research 2006;66(6):3338-44.
2006: Kevin Pruitt; Rebekah L Zinn; Joyce E Ohm; Kelly M McGarvey; Sung-Hae L Kang; DAVID WATKINS; James G Herman; Stephen B Baylin
Inhibition of SIRT1 reactivates silenced cancer genes without loss of promoter DNA hypermethylation.
PLoS genetics 2006;2(3):e40.
2006: Debby M E I Hellebrekers; Kam-Wing Jair; Emmanuelle Viré; Sayaka Eguchi; Nicole T H Hoebers; Mario F Fraga; Manel Esteller; François Fuks; Stephen B Baylin; Manon van Engeland; Arjan W Griffioen
Angiostatic activity of DNA methyltransferase inhibitors.
Molecular cancer therapeutics 2006;5(2):467-75.
2006: Stephen B Baylin; Joyce E Ohm
Epigenetic gene silencing in cancer - a mechanism for early oncogenic pathway addiction?
Nature reviews. Cancer 2006;6(2):107-16.
2006: Angela H Ting; Kam-Wing Jair; Kornel E Schuebel; Stephen B Baylin
Differential requirement for DNA methyltransferase 1 in maintaining human cancer cell gene promoter hypermethylation.
Cancer research 2006;66(2):729-35.
2006: Kam-Wing Jair; Kurtis E Bachman; Hiromu Suzuki; Angela H Ting; Ina Rhee; Ray-Whay Chiu Yen; Stephen B Baylin; Kornel E Schuebel
De novo CpG island methylation in human cancer cells.
Cancer research 2006;66(2):682-92.
2006: Oliver Galm; James G Herman; Stephen B Baylin
The fundamental role of epigenetics in hematopoietic malignancies.
Blood reviews 2006;20(1):1-13.
2005: Stephen B Baylin
DNA methylation and gene silencing in cancer.
Nature clinical practice. Oncology 2005;2 Suppl 1():S4-11.
2005: Stephen B Baylin; Ghulam J Mufti
Myelodysplastic syndromes (MDSs) and acute myelogenous leukemia (AML) comprise a closely linked continuum of malignant hematologic diseases. Introduction.
Nature clinical practice. Oncology 2005;2 Suppl 1():S1-3.
2005: Wen Yong Chen; David H Wang; Ray-Whay Chiu Yen; Jianyuan Luo; Wei Gu; Stephen B Baylin
Tumor suppressor HIC1 directly regulates SIRT1 to modulate p53-dependent DNA-damage responses.
Cell 2005;123(3):437-48.
2005: Malcolm V Brock; Craig M Hooker; Rex C-W Yung; Mingzhou Guo; Yu Han; Stephen E Ames; David C Chang; Stephen C Yang; David Mason; Marc S Sussman; Stephen B Baylin; James G Herman
Can we improve the cytologic examination of malignant pleural effusions using molecular analysis?
The Annals of thoracic surgery 2005;80(4):1241-7.
2005: Kornel E Schuebel; Stephen B Baylin
In living color: DNA methyltransferase caught in the act.
Nature methods 2005;2(10):736-8.
2005: Angela H Ting; Kornel E Schuebel; James G Herman; Stephen B Baylin
Short double-stranded RNA induces transcriptional gene silencing in human cancer cells in the absence of DNA methylation.
Nature genetics 2005;37(8):906-10.
2005: Oliver Galm; Hiromu Suzuki; Yoshimitsu Akiyama; Manel Esteller; Malcolm V Brock; Rainhardt Osieka; Stephen B Baylin; James G Herman
Inactivation of the tissue inhibitor of metalloproteinases-2 gene by promoter hypermethylation in lymphoid malignancies.
Oncogene 2005;24(30):4799-805.
2005: Stephen B Baylin; WenYong Chen
Aberrant gene silencing in tumor progression: implications for control of cancer.
Cold Spring Harbor symposia on quantitative biology 2005;70():427-33.
2005: Malcolm V Brock; Craig M Hooker; James E Syphard; William H Westra; Li Xu; Anthony J Alberg; David Mason; Stephen B Baylin; James G Herman; Rex C-W Yung; Julie R Brahmer; Charles Rudin; David S Ettinger; Stephen C Yang
Surgical resection of limited disease small cell lung cancer in the new era of platinum chemotherapy: Its time has come.
The Journal of thoracic and cardiovascular surgery 2005;129(1):64-72.
2005: Wen Yong Chen; Stephen B Baylin
Inactivation of tumor suppressor genes: choice between genetic and epigenetic routes.
Cell cycle (Georgetown, Tex.) 2005;4(1):10-2.
2004: Mingzhou Guo; Yoshimitsu Akiyama; Michael G House; Craig M Hooker; Elisabeth Iljas Heath; Edward Gabrielson; Stephen C Yang; Yu Han; Stephen B Baylin; James G Herman; Malcolm V Brock
Hypermethylation of the GATA genes in lung cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(23):7917-24.
2004: WenYong Chen; Timothy K Cooper; Cynthia A Zahnow; Michael Overholtzer; Zhiquan Zhao; Marc Ladanyi; Judith E Karp; Nalan Gokgoz; Jay S Wunder; Irene L Andrulis; Arnold J Levine; Joseph L Mankowski; Stephen B Baylin
Epigenetic and genetic loss of Hic1 function accentuates the role of p53 in tumorigenesis.
Cancer cell 2004;6(4):387-98.
2004: Mingzhou Guo; Michael G House; Craig M Hooker; Yu Han; Elisabeth Iljas Heath; Edward Gabrielson; Stephen C Yang; Stephen B Baylin; James G Herman; Malcolm V Brock
Promoter hypermethylation of resected bronchial margins: a field defect of changes?
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(15):5131-6.
2004: Angela H Ting; Kam-Wing Jair; Hiromu Suzuki; Ray-Whay Chiu Yen; Stephen B Baylin; Kornel E Schuebel
Mammalian DNA methyltransferase 1: inspiration for new directions.
Cell cycle (Georgetown, Tex.) 2004;3(8):1024-6.
2004: Angela H Ting; Kam-Wing Jair; Hiromu Suzuki; Ray-Whay Chiu Yen; Stephen B Baylin; Kornel E Schuebel
CpG island hypermethylation is maintained in human colorectal cancer cells after RNAi-mediated depletion of DNMT1.
Nature genetics 2004;36(6):582-4.
2004: YOON YOUNG JANG; Michael I Collector; Stephen B Baylin; Anna Mae Diehl; Saul J Sharkis
Hematopoietic stem cells convert into liver cells within days without fusion.
Nature cell biology 2004;6(6):532-9.
2004: Hiromu Suzuki; DAVID WATKINS; Kam-Wing Jair; Kornel E Schuebel; Sanford D Markowitz; Wei Dong Chen; Theresa P Pretlow; Bin Yang; Yoshimitsu Akiyama; Manon van Engeland; Minoru Toyota; Takashi Tokino; Yuji Hinoda; Kohzoh Imai; James G Herman; Stephen B Baylin
Epigenetic inactivation of SFRP genes allows constitutive WNT signaling in colorectal cancer.
Nature genetics 2004;36(4):417-22.
2004: Robert Stoehr; Christoph Wissmann; Hiromu Suzuki; Ruth Knuechel; Rene C Krieg; Eva Klopocki; Edgar Dahl; Peter Wild; Hagen Blaszyk; Guido Sauter; Ronald Simon; Ruediger Schmitt; Dirk Zaak; Ferdinand Hofstaedter; André Rosenthal; Stephen B Baylin; Christian Pilarsky; Arndt Hartmann
Deletions of chromosome 8p and loss of sFRP1 expression are progression markers of papillary bladder cancer.
Laboratory investigation; a journal of technical methods and pathology 2004;84(4):465-78.
2004: Donna Douglas; Yoshimitsu Akiyama; Hetty Carraway; Steven A Belinsky; Manel Esteller; Edward Gabrielson; Sigmund Weitzman; Trevor Williams; James G Herman; Stephen B Baylin
Hypermethylation of a small CpGuanine-rich region correlates with loss of activator protein-2alpha expression during progression of breast cancer.
Cancer research 2004;64(5):1611-20.
2004: Stephen B Baylin
Reversal of gene silencing as a therapeutic target for cancer--roles for DNA methylation and its interdigitation with chromatin.
Novartis Foundation symposium 2004;259():226-33; discussion 234-7, 285-8.
2003: Yoshimitsu Akiyama; Neil Watkins; Hiromu Suzuki; Kam-Wing Jair; Manon van Engeland; Manel Esteller; Hidekazu Sakai; Chun-Yan Ren; Yasuhito Yuasa; James G Herman; Stephen B Baylin
GATA-4 and GATA-5 transcription factor genes and potential downstream antitumor target genes are epigenetically silenced in colorectal and gastric cancer.
Molecular and cellular biology 2003;23(23):8429-39.
2003: James G Herman; Stephen B Baylin
Gene silencing in cancer in association with promoter hypermethylation.
The New England journal of medicine 2003;349(21):2042-54.
2003: Steven A Belinsky; Donna M Klinge; Christine A Stidley; Jean-Pierre J Issa; James G Herman; Thomas H March; Stephen B Baylin
Inhibition of DNA methylation and histone deacetylation prevents murine lung cancer.
Cancer research 2003;63(21):7089-93.
2003: Malcolm V Brock; Mingzhou Gou; Yoshimitsu Akiyama; Alison Muller; Tsung-Teh Wu; Elizabeth Montgomery; Mari Deasel; Paul Germonpré; Lewis Rubinson; Richard F Heitmiller; Stephen C Yang; Arlene A Forastiere; Stephen B Baylin; James G Herman
Prognostic importance of promoter hypermethylation of multiple genes in esophageal adenocarcinoma.
Clinical cancer research : an official journal of the American Association for Cancer Research 2003;9(8):2912-9.
2003: William A Palmisano; Kevin P Crume; Marcie J Grimes; Sally A Winters; Minoru Toyota; Manel Esteller; Nancy E Joste; Stephen B Baylin; Steven A Belinsky
Aberrant promoter methylation of the transcription factor genes PAX5 alpha and beta in human cancers.
Cancer research 2003;63(15):4620-5.
2003: Jill A Fahrner; Stephen B Baylin
Heterochromatin: stable and unstable invasions at home and abroad.
Genes & development 2003;17(15):1805-12.
2003: Manon van Engeland; Matty P Weijenberg; Guido M J M Roemen; Mirian Brink; Adriaan P de Bruïne; R Alexandra Goldbohm; Piet A van den Brandt; Stephen B Baylin; Anton F P M de Goeij; James G Herman
Effects of dietary folate and alcohol intake on promoter methylation in sporadic colorectal cancer: the Netherlands cohort study on diet and cancer.
Cancer research 2003;63(12):3133-7.
2003: DAVID WATKINS; berman david; Stephen B Baylin
Hedgehog signaling: progenitor phenotype in small-cell lung cancer.
Cell cycle (Georgetown, Tex.) 2003;2(3):196-8.
2003: Brian E Reese; Kurtis E Bachman; Stephen B Baylin; Michael R Rountree
The methyl-CpG binding protein MBD1 interacts with the p150 subunit of chromatin assembly factor 1.
Molecular and cellular biology 2003;23(9):3226-36.
2003: Charles R Holst; Gerard J Nuovo; Manel Esteller; Karen L Chew; Stephen B Baylin; James G Herman; Thea D Tlsty
Methylation of p16(INK4a) promoters occurs in vivo in histologically normal human mammary epithelia.
Cancer research 2003;63(7):1596-601.
2003: DAVID WATKINS; berman david; Scott G Burkholder; Baolin Wang; Philip A Beachy; Stephen B Baylin
Hedgehog signalling within airway epithelial progenitors and in small-cell lung cancer.
Nature 2003;422(6929):313-7.
2003: Wen Yong Chen; Xiaobei Zeng; Mark Carter; Craig N Morrell; Ray-Whay Chiu Yen; Manel Esteller; DAVID WATKINS; James G Herman; Joseph L Mankowski; Stephen B Baylin
Heterozygous disruption of Hic1 predisposes mice to a gender-dependent spectrum of malignant tumors.
Nature genetics 2003;33(2):197-202.
2003: Kurtis E Bachman; Ben Ho Park; Ina Rhee; Harith Rajagopalan; James G Herman; Stephen B Baylin; Kenneth W Kinzler; Bert Vogelstein
Histone modifications and silencing prior to DNA methylation of a tumor suppressor gene.
Cancer cell 2003;3(1):89-95.
2002: Jill A Fahrner; Sayaka Eguchi; James G Herman; Stephen B Baylin
Dependence of histone modifications and gene expression on DNA hypermethylation in cancer.
Cancer research 2002;62(24):7213-8.
2002: Manel Esteller; Mingzhou Guo; Victor Moreno; Miquel Angel Peinado; Gabriel Capella; Oliver Galm; Stephen B Baylin; James G Herman
Hypermethylation-associated Inactivation of the Cellular Retinol-Binding-Protein 1 Gene in Human Cancer.
Cancer research 2002;62(20):5902-5.
2002: Elizabeth Cameron; Aleksandar Mijovic; James G Herman; Stephen B Baylin; Anjala Pradhan; Ghulam J Mufti; Feyruz V Rassool
P15INK4B is not mutated in adult familial myelodysplastic syndromes.
British journal of haematology 2002;119(1):277-9.
2002: Stephen B Baylin
Mechanisms underlying epigenetically mediated gene silencing in cancer.
Seminars in cancer biology 2002;12(5):331-7.
2002: Peter A Jones; Stephen B Baylin
The fundamental role of epigenetic events in cancer.
Nature reviews. Genetics 2002;3(6):415-28.
2002: Hiromu Suzuki; Edward Gabrielson; Wei Chen; Ramaswamy Anbazhagan; Manon van Engeland; Matty P Weijenberg; James G Herman; Stephen B Baylin
A genomic screen for genes upregulated by demethylation and histone deacetylase inhibition in human colorectal cancer.
Nature genetics 2002;31(2):141-9.
2002: Stephen B Baylin; Timothy H Bestor
Altered methylation patterns in cancer cell genomes: cause or consequence?
Cancer cell 2002;1(4):299-305.
2002: Ina Rhee; Kurtis E Bachman; Ben Ho Park; Kam-Wing Jair; Ray-Whay Chiu Yen; Kornel E Schuebel; Hengmi Cui; Andrew P Feinberg; Christoph Lengauer; Kenneth W Kinzler; Stephen B Baylin; Bert Vogelstein
DNMT1 and DNMT3b cooperate to silence genes in human cancer cells.
Nature 2002;416(6880):552-6.
2002: Max M van Noesel; Saskia van Bezouw; Gajja S Salomons; Paul A Voûte; Rob Pieters; Stephen B Baylin; James G Herman; Rogier Versteeg
Tumor-specific down-regulation of the tumor necrosis factor-related apoptosis-inducing ligand decoy receptors DcR1 and DcR2 is associated with dense promoter hypermethylation.
Cancer research 2002;62(7):2157-61.
2002: Manel Esteller; Gianluca Gaidano; Steven Goodman; Vittorina Zagonel; Daniela Capello; Barbara Botto; Davide Rossi; Annunziata Gloghini; Umberto Vitolo; Antonino Carbone; Stephen B Baylin; James G Herman
Hypermethylation of the DNA repair gene O(6)-methylguanine DNA methyltransferase and survival of patients with diffuse large B-cell lymphoma.
Journal of the National Cancer Institute 2002;94(1):26-32.
2002: Oliver Galm; Michael R Rountree; Kurtis E Bachman; Kam-Wing Jair; Stephen B Baylin; James G Herman
Enzymatic regional methylation assay: a novel method to quantify regional CpG methylation density.
Genome research 2002;12(1):153-7.
2001: Manel Esteller; Mario F Fraga; Mingzhou Guo; J Garcia-Foncillas; I Hedenfalk; A K Godwin; J Trojan; Catherine Vaurs-Barrière; Yves-Jean Bignon; S Ramus; J Benitez; T Caldes; Y Akiyama; Y Yuasa; Virpi Launonen; M J Canal; R Rodriguez; Gabriel Capella; Miguel A Peinado; A Borg; L A Aaltonen; bruce ponder; Stephen B Baylin; James G Herman
DNA methylation patterns in hereditary human cancers mimic sporadic tumorigenesis.
Human molecular genetics 2001;10(26):3001-7.
2001: Kurtis E Bachman; Michael R Rountree; Stephen B Baylin
Dnmt3a and Dnmt3b are transcriptional repressors that exhibit unique localization properties to heterochromatin.
The Journal of biological chemistry 2001;276(34):32282-7.
2001: Manel Esteller; Rosa-Ana Risques; M Toyota; Gabriel Capella; Victor Moreno; Miguel A Peinado; Stephen B Baylin; James G Herman
Promoter hypermethylation of the DNA repair gene O(6)-methylguanine-DNA methyltransferase is associated with the presence of G:C to A:T transition mutations in p53 in human colorectal tumorigenesis.
Cancer research 2001;61(12):4689-92.
2001: Michael R Rountree; Kurtis E Bachman; James G Herman; Stephen B Baylin
DNA methylation, chromatin inheritance, and cancer.
Oncogene 2001;20(24):3156-65.
2001: Stephen B Baylin; James G Herman
Promoter hypermethylation--can this change alone ever designate true tumor suppressor gene function?
Journal of the National Cancer Institute 2001;93(9):664-5.
2001: James G Herman; Stephen B Baylin
Methylation-specific PCR.
Current protocols in human genetics / editorial board, Jonathan L. Haines ... [et al.] 2001;Chapter 10():Unit 10.6.
2001: Manel Esteller; P G Corn; Stephen B Baylin; James G Herman
A gene hypermethylation profile of human cancer.
Cancer research 2001;61(8):3225-9.
2001: Virote Sriuranpong; Michael W Borges; Rajani Ravi; D R Arnold; Barry D Nelkin; Stephen B Baylin; Douglas W Ball
Notch signaling induces cell cycle arrest in small cell lung cancer cells.
Cancer research 2001;61(7):3200-5.
2001: Manel Esteller; C Cordon-Cardo; P G Corn; Meltzer Stephen J.; K S Pohar; DAVID WATKINS; Gabriel Capella; Miguel A Peinado; X Matias-Guiu; J Prat; Stephen B Baylin; James G Herman
p14ARF silencing by promoter hypermethylation mediates abnormal intracellular localization of MDM2.
Cancer research 2001;61(7):2816-21.
2001: Stephen B Baylin; Manel Esteller; Michael R Rountree; Kurtis E Bachman; Kornel E Schuebel; James G Herman
Aberrant patterns of DNA methylation, chromatin formation and gene expression in cancer.
Human molecular genetics 2001;10(7):687-92.
2001: S Myöhänen; Stephen B Baylin
Sequence-specific DNA binding activity of RNA helicase A to the p16INK4a promoter.
The Journal of biological chemistry 2001;276(2):1634-42.
2001: Stephen B Baylin
DNA methylation and epigenetic mechanisms of carcinogenesis.
Developments in biologicals 2001;106():85-7; discussion 143-60.
2000: M Esteller; Jesus Garcia-Foncillas; Esther Andion; Steven Goodman; O F Hidalgo; V Vanaclocha; Stephen B Baylin; James G Herman
Inactivation of the DNA-repair gene MGMT and the clinical response of gliomas to alkylating agents.
The New England journal of medicine 2000;343(19):1350-4.
2000: P G Corn; B Douglas Smith; E S Ruckdeschel; D Douglas; Stephen B Baylin; James G Herman
E-cadherin expression is silenced by 5' CpG island methylation in acute leukemia.
Clinical cancer research : an official journal of the American Association for Cancer Research 2000;6(11):4243-8.
2000: William A Palmisano; Kevin K Divine; G Saccomanno; Frank D Gilliland; Stephen B Baylin; James G Herman; Steven A Belinsky
Predicting lung cancer by detecting aberrant promoter methylation in sputum.
Cancer research 2000;60(21):5954-8.
2000: Stephen B Baylin; S A Belinsky; James G Herman
Aberrant methylation of gene promoters in cancer---concepts, misconcepts, and promise.
Journal of the National Cancer Institute 2000;92(18):1460-1.
2000: Manel Esteller; A Sparks; M Toyota; Montserrat Sanchez-Cespedes; Gabriel Capella; Miguel A Peinado; S Gonzalez; Gemma Tarafa; David Sidransky; Meltzer Stephen J.; Stephen B Baylin; James G Herman
Analysis of adenomatous polyposis coli promoter hypermethylation in human cancer.
Cancer research 2000;60(16):4366-71.
2000: R Ilona Linnoila; B Zhao; Janet DeMayo; Barry D Nelkin; Stephen B Baylin; Francesco J DeMayo; Douglas W Ball
Constitutive achaete-scute homologue-1 promotes airway dysplasia and lung neuroendocrine tumors in transgenic mice.
Cancer research 2000;60(15):4005-9.
2000: Michael R Rountree; Kurtis E Bachman; Stephen B Baylin
DNMT1 binds HDAC2 and a new co-repressor, DMAP1, to form a complex at replication foci.
Nature genetics 2000;25(3):269-77.
2000: A Krasner; L Wallace; A Thiagalingam; C Jones; Christoph Lengauer; L Minahan; Y Ma; L Kalikin; Andrew P Feinberg; Ethylin Jabs; A Tunnacliffe; Stephen B Baylin; Douglas W Ball; Barry D Nelkin
Cloning and chromosomal localization of the human BARX2 homeobox protein gene.
Gene 2000;250(1-2):171-80.
2000: Manel Esteller; M Toyota; Montserrat Sanchez-Cespedes; Gabriel Capella; Miguel A Peinado; DAVID WATKINS; Jean-Pierre J Issa; David Sidransky; Stephen B Baylin; James G Herman
Inactivation of the DNA repair gene O6-methylguanine-DNA methyltransferase by promoter hypermethylation is associated with G to A mutations in K-ras in colorectal tumorigenesis.
Cancer research 2000;60(9):2368-71.
2000: Ina Rhee; Kam-Wing Jair; Ray-Whay Chiu Yen; Christoph Lengauer; James G Herman; Kenneth W Kinzler; Bert Vogelstein; Stephen B Baylin; Kornel E Schuebel
CpG methylation is maintained in human cancer cells lacking DNMT1.
Nature 2000;404(6781):1003-7.
2000: M Esteller; J M Silva; G Dominguez; F Bonilla; Xavier Matias-Guiu; E Lerma; Elena Bussaglia; Jaime Prat; IC Harkes; E A Repasky; Edward Gabrielson; Mieke Schutte; Stephen B Baylin; James G Herman
Promoter hypermethylation and BRCA1 inactivation in sporadic breast and ovarian tumors.
Journal of the National Cancer Institute 2000;92(7):564-9.
2000: Gamil R Antoun; Stephen B Baylin; Francis Ali-Osman
DNA methyltransferase levels and altered CpG methylation in the total genome and in the GSTP1 gene in human glioma cells transfected with sense and antisense DNA methyltransferase cDNA.
Journal of cellular biochemistry 2000;77(3):372-81.
2000: Stephen B Baylin; James G Herman
DNA hypermethylation in tumorigenesis: epigenetics joins genetics.
Trends in genetics : TIG 2000;16(4):168-74.
2000: Mark Carter; M A Johns; X Zeng; Li Zhou; MARY ZINK; Joseph L Mankowski; D M Donovan; Stephen B Baylin
Mice deficient in the candidate tumor suppressor gene Hic1 exhibit developmental defects of structures affected in the Miller-Dieker syndrome.
Human molecular genetics 2000;9(3):413-9.
2000: C Eng; James G Herman; Stephen B Baylin
A bird's eye view of global methylation.
Nature genetics 2000;24(2):101-2.
2000: Jeremy R Graff; Edward Gabrielson; H Fujii; Stephen B Baylin; James G Herman
Methylation patterns of the E-cadherin 5' CpG island are unstable and reflect the dynamic, heterogeneous loss of E-cadherin expression during metastatic progression.
The Journal of biological chemistry 2000;275(4):2727-32.
2000: Manel Esteller; E Avizienyte; P G Corn; Ragnhild A Lothe; Stephen B Baylin; Lauri A Aaltonen; James G Herman
Epigenetic inactivation of LKB1 in primary tumors associated with the Peutz-Jeghers syndrome.
Oncogene 2000;19(1):164-8.
2000: James G Herman; Stephen B Baylin
Promoter-region hypermethylation and gene silencing in human cancer.
Current topics in microbiology and immunology 2000;249():35-54.
2000: M Esteller; Silvia Tortola; Minoru Toyota; G Capella; Miguel A Peinado; Stephen B Baylin; James G Herman
Hypermethylation-associated inactivation of p14(ARF) is independent of p16(INK4a) methylation and p53 mutational status.
Cancer research 2000;60(1):129-33.
1999: Minoru Toyota; NITA AHUJA; H Suzuki; F Itoh; M Ohe-Toyota; K Imai; Stephen B Baylin; Jean-Pierre J Issa
Aberrant methylation in gastric cancer associated with the CpG island methylator phenotype.
Cancer research 1999;59(21):5438-42.
1999: M Esteller; Lluis Catasus; Xavier Matias-Guiu; G L Mutter; Jaime Prat; Stephen B Baylin; James G Herman
hMLH1 promoter hypermethylation is an early event in human endometrial tumorigenesis.
The American journal of pathology 1999;155(5):1767-72.
1999: G J Nuovo; T W Plaia; S A Belinsky; Stephen B Baylin; James G Herman
In situ detection of the hypermethylation-induced inactivation of the p16 gene as an early event in oncogenesis.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(22):12754-9.
1999: E E Cameron; Stephen B Baylin; James G Herman
p15(INK4B) CpG island methylation in primary acute leukemia is heterogeneous and suggests density as a critical factor for transcriptional silencing.
Blood 1999;94(7):2445-51.
1999: Minoru Toyota; C Ho; M Ohe-Toyota; Stephen B Baylin; Jean-Pierre J Issa
Inactivation of CACNA1G, a T-type calcium channel gene, by aberrant methylation of its 5' CpG island in human tumors.
Cancer research 1999;59(18):4535-41.
1999: Minoru Toyota; NITA AHUJA; M Ohe-Toyota; James G Herman; Stephen B Baylin; Jean-Pierre J Issa
CpG island methylator phenotype in colorectal cancer.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(15):8681-6.
1999: P G Corn; Steven J Kuerbitz; M M van Noesel; M Esteller; Nicole Compitello; Stephen B Baylin; James G Herman
Transcriptional silencing of the p73 gene in acute lymphoblastic leukemia and Burkitt's lymphoma is associated with 5' CpG island methylation.
Cancer research 1999;59(14):3352-6.
1999: R A Katzenellenbogen; Stephen B Baylin; James G Herman
Hypermethylation of the DAP-kinase CpG island is a common alteration in B-cell malignancies.
Blood 1999;93(12):4347-53.
1999: Minoru Toyota; C Ho; NITA AHUJA; Kam-Wing Jair; Qing Li; M Ohe-Toyota; Stephen B Baylin; Jean-Pierre J Issa
Identification of differentially methylated sequences in colorectal cancer by methylated CpG island amplification.
Cancer research 1999;59(10):2307-12.
1999: L M McGregor; B K McCune; J R Graff; P R McDowell; Katharine E Romans; G D Yancopoulos; Douglas W Ball; Stephen B Baylin; Barry D Nelkin
Roles of trk family neurotrophin receptors in medullary thyroid carcinoma development and progression.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(8):4540-5.
1999: Kurtis E Bachman; James G Herman; P G Corn; A Merlo; Joseph F Costello; W K Cavenee; Stephen B Baylin; Jeremy R Graff
Methylation-associated silencing of the tissue inhibitor of metalloproteinase-3 gene suggest a suppressor role in kidney, brain, and other human cancers.
Cancer research 1999;59(4):798-802.
1999: Manel Esteller; Stanley R Hamilton; Peter C Burger; Stephen B Baylin; James G Herman
Inactivation of the DNA repair gene O6-methylguanine-DNA methyltransferase by promoter hypermethylation is a common event in primary human neoplasia.
Cancer research 1999;59(4):793-7.
1999: Steven J Kuerbitz; J Malandro; Nicole Compitello; Stephen B Baylin; J R Graff
Deletion of p16INK4A/CDKN2 and p15INK4B in human somatic cell hybrids and hybrid-derived tumors.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1999;10(1):27-33.
1999: E E Cameron; Kurtis E Bachman; S Myöhänen; James G Herman; Stephen B Baylin
Synergy of demethylation and histone deacetylase inhibition in the re-expression of genes silenced in cancer.
Nature genetics 1999;21(1):103-7.
1999: Manel Esteller; Montserrat Sanchez-Cespedes; R Rosell; David Sidransky; Stephen B Baylin; James G Herman
Detection of aberrant promoter hypermethylation of tumor suppressor genes in serum DNA from non-small cell lung cancer patients.
Cancer research 1999;59(1):67-70.
1998: NITA AHUJA; Qing Li; A L Mohan; Stephen B Baylin; Jean-Pierre J Issa
Aging and DNA methylation in colorectal mucosa and cancer.
Cancer research 1998;58(23):5489-94.
1998: Manel Esteller; Ross Levine; Stephen B Baylin; L H Ellenson; James G Herman
MLH1 promoter hypermethylation is associated with the microsatellite instability phenotype in sporadic endometrial carcinomas.
Oncogene 1998;17(18):2413-7.
1998: Manel Esteller; P G Corn; J M Urena; Edward Gabrielson; Stephen B Baylin; James G Herman
Inactivation of glutathione S-transferase P1 gene by promoter hypermethylation in human neoplasia.
Cancer research 1998;58(20):4515-8.
1998: Steven A Belinsky; Kristen J Nikula; William A Palmisano; R Michels; G Saccomanno; Edward Gabrielson; Stephen B Baylin; James G Herman
Aberrant methylation of p16(INK4a) is an early event in lung cancer and a potential biomarker for early diagnosis.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(20):11891-6.
1998: A Narayan; W Ji; X Y Zhang; A Marrogi; J R Graff; Stephen B Baylin; Melanie Ehrlich
Hypomethylation of pericentromeric DNA in breast adenocarcinomas.
International journal of cancer. Journal international du cancer 1998;77(6):833-8.
1998: Judy A Mikovits; H A Young; Paula M Vertino; Jean-Pierre J Issa; PAULA PITHA-ROWE; S Turcoski-Corrales; Dennis D Taub; C L Petrow; Stephen B Baylin; Francis W Ruscetti
Infection with human immunodeficiency virus type 1 upregulates DNA methyltransferase, resulting in de novo methylation of the gamma interferon (IFN-gamma) promoter and subsequent downregulation of IFN-gamma production.
Molecular and cellular biology 1998;18(9):5166-77.
1998: Eleanor B Carson-Walter; D P Smith; bruce ponder; Stephen B Baylin; Barry D Nelkin
Post-transcriptional silencing of RET occurs, but is not required, during raf-1 mediated differentiation of medullary thyroid carcinoma cells.
Oncogene 1998;17(3):367-76.
1998: Qing Li; Anne E Jedlicka; NITA AHUJA; M C Gibbons; Stephen B Baylin; Peter C Burger; Jean-Pierre J Issa
Concordant methylation of the ER and N33 genes in glioblastoma multiforme.
Oncogene 1998;16(24):3197-202.
1998: James G Herman; A Umar; Kornelia Polyak; Jeremy R Graff; NITA AHUJA; Jean-Pierre J Issa; Sanford Markowitz; James Willson; Stanley R Hamilton; Kenneth W Kinzler; Michael F Kane; Richard D Kolodner; Bert Vogelstein; T A Kunkel; Stephen B Baylin
Incidence and functional consequences of hMLH1 promoter hypermethylation in colorectal carcinoma.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(12):6870-5.
1998: Herbert Chen; J R Roberts; Douglas W Ball; D W Eisele; Stephen B Baylin; R Udelsman; G B Bulkley
Effective long-term palliation of symptomatic, incurable metastatic medullary thyroid cancer by operative resection.
Annals of surgery 1998;227(6):887-95.
1998: Jeremy R Graff; V E Greenberg; James G Herman; William H Westra; ER Boghaert; Kenneth B Ain; Motoyasu Saji; Martha A Zeiger; Stephen G Zimmer; Stephen B Baylin
Distinct patterns of E-cadherin CpG island methylation in papillary, follicular, Hurthle's cell, and poorly differentiated human thyroid carcinoma.
Cancer research 1998;58(10):2063-6.
1998: S Hiraguri; T Godfrey; H Nakamura; J Graff; Colin Collins; L Shayesteh; N Doggett; K Johnson; M Wheelock; James G Herman; Stephen B Baylin; Daniel Pinkel; Joe Gray
Mechanisms of inactivation of E-cadherin in breast cancer cell lines.
Cancer research 1998;58(9):1972-7.
1998: H Fujii; M A Biel; W Zhou; Sigmund A Weitzman; Stephen B Baylin; Edward Gabrielson
Methylation of the HIC-1 candidate tumor suppressor gene in human breast cancer.
Oncogene 1998;16(16):2159-64.
1998: S K Myöhänen; Stephen B Baylin; James G Herman
Hypermethylation can selectively silence individual p16ink4A alleles in neoplasia.
Cancer research 1998;58(4):591-3.
1998: Rajani Ravi; E Weber; M McMahon; JR Williams; Stephen B Baylin; Asoke K Mal; Marian L Harter; Larry E Dillehay; P P Claudio; Antonio Giordano; Barry D Nelkin; M Mabry
Activated Raf-1 causes growth arrest in human small cell lung cancer cells.
The Journal of clinical investigation 1998;101(1):153-9.
1998: Stephen B Baylin; James G Herman; Jeremy R Graff; Paula M Vertino; Jean-Pierre J Issa
Alterations in DNA methylation: a fundamental aspect of neoplasia.
Advances in cancer research 1998;72():141-96.
1997: AT Ferguson; Paula M Vertino; Jeff Spitzner; Stephen B Baylin; Mark T Muller; Nancy E Davidson
Role of estrogen receptor gene demethylation and DNA methyltransferase.DNA adduct formation in 5-aza-2'deoxycytidine-induced cytotoxicity in human breast cancer cells.
The Journal of biological chemistry 1997;272(51):32260-6.
1997: A Thiagalingam; Christoph Lengauer; Stephen B Baylin; Barry D Nelkin
RREB1, a ras responsive element binding protein, maps to human chromosome 6p25.
Genomics 1997;45(3):630-2.
1997: DJ Yamashiro; Xing-ge Liu; C P Lee; A Nakagawara; Naohiko Ikegaki; L M McGregor; Stephen B Baylin; Garrett M Brodeur
Expression and function of Trk-C in favourable human neuroblastomas.
European journal of cancer (Oxford, England : 1990) 1997;33(12):2054-7.
1997: Stephen B Baylin
Tying it all together: epigenetics, genetics, cell cycle, and cancer.
Science (New York, N.Y.) 1997;277(5334):1948-9.
1997: Jeremy R Graff; James G Herman; S Myöhänen; Stephen B Baylin; Paula M Vertino
Mapping patterns of CpG island methylation in normal and neoplastic cells implicates both upstream and downstream regions in de novo methylation.
The Journal of biological chemistry 1997;272(35):22322-9.
1997: NITA AHUJA; A L Mohan; Qing Li; J M Stolker; James G Herman; Stanley R Hamilton; Stephen B Baylin; Jean-Pierre J Issa
Association between CpG island methylation and microsatellite instability in colorectal cancer.
Cancer research 1997;57(16):3370-4.
1997: Mieke Schutte; Ralph Hruban; Joseph Geradts; R Maynard; Werner Hilgers; S K Rabindran; Christopher A Moskaluk; Stephan Hahn; Irmgard Schwarte-Waldhoff; Wolff Schmiegel; Stephen B Baylin; Scott E Kern; James G Herman
Abrogation of the Rb/p16 tumor-suppressive pathway in virtually all pancreatic carcinomas.
Cancer research 1997;57(15):3126-30.
1997: Herbert Chen; M A Biel; Michael W Borges; A Thiagalingam; Barry D Nelkin; Stephen B Baylin; Douglas W Ball
Tissue-specific expression of human achaete-scute homologue-1 in neuroendocrine tumors: transcriptional regulation by dual inhibitory regions.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1997;8(6):677-86.
1997: David F Jarrard; G Steven Bova; Charles M Ewing; Sokhom Pin; SH Nguyen; Stephen B Baylin; Paul Cairns; David Sidransky; James G Herman; William B Isaacs
Deletional, mutational, and methylation analyses of CDKN2 (p16/MTS1) in primary and metastatic prostate cancer.
Genes, chromosomes & cancer 1997;19(2):90-6.
1997: Herbert Chen; A Thiagalingam; H Chopra; Michael W Borges; J N Feder; Barry D Nelkin; Stephen B Baylin; Douglas W Ball
Conservation of the Drosophila lateral inhibition pathway in human lung cancer: a hairy-related protein (HES-1) directly represses achaete-scute homolog-1 expression.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(10):5355-60.
1997: T Kubota; S Das; S L Christian; Stephen B Baylin; James G Herman; David Ledbetter
Methylation-specific PCR simplifies imprinting analysis.
Nature genetics 1997;16(1):16-7.
1997: Jean-Pierre J Issa; B A Zehnbauer; S H Kaufmann; M A Biel; Stephen B Baylin
HIC1 hypermethylation is a late event in hematopoietic neoplasms.
Cancer research 1997;57(9):1678-81.
1997: M Borges; R Ilona Linnoila; H J van de Velde; Herbert Chen; Barry D Nelkin; M Mabry; Stephen B Baylin; Douglas W Ball
An achaete-scute homologue essential for neuroendocrine differentiation in the lung.
Nature 1997;386(6627):852-5.
1997: L F Barr; SE Campbell; Stephen B Baylin
Protein kinase C-beta 2 inhibits cycling and decreases c-myc-induced apoptosis in small cell lung cancer cells.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1997;8(4):381-92.
1997: Jean-Pierre J Issa; Stephen B Baylin; James G Herman
DNA methylation changes in hematologic malignancies: biologic and clinical implications.
Leukemia 1997;11 Suppl 1():S7-11.
1997: James G Herman; Curt I Civin; Jean-Pierre J Issa; Michael I Collector; Saul J Sharkis; Stephen B Baylin
Distinct patterns of inactivation of p15INK4B and p16INK4A characterize the major types of hematological malignancies.
Cancer research 1997;57(5):837-41.
1997: DS Swafford; S K Middleton; William A Palmisano; Kristen J Nikula; Yohannes Tesfaigzi; Stephen B Baylin; James G Herman; Steven A Belinsky
Frequent aberrant methylation of p16INK4a in primary rat lung tumors.
Molecular and cellular biology 1997;17(3):1366-74.
1996: Jeffrey A Yoder; Ray-Whay Chiu Yen; Paula M Vertino; Timothy H Bestor; Stephen B Baylin
New 5' regions of the murine and human genes for DNA (cytosine-5)-methyltransferase.
The Journal of biological chemistry 1996;271(49):31092-7.
1996: Jean-Pierre J Issa; Paula M Vertino; Corinne D Boehm; Irene Newsham; Stephen B Baylin
Switch from monoallelic to biallelic human IGF2 promoter methylation during aging and carcinogenesis.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(21):11757-62.
1996: A Thiagalingam; A De Bustros; M Borges; R Jasti; D Compton; L Diamond; M Mabry; Douglas W Ball; Stephen B Baylin; Barry D Nelkin
RREB-1, a novel zinc finger protein, is involved in the differentiation response to Ras in human medullary thyroid carcinomas.
Molecular and cellular biology 1996;16(10):5335-45.
1996: James G Herman; Jeremy R Graff; S Myöhänen; Barry D Nelkin; Stephen B Baylin
Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(18):9821-6.
1996: L F Barr; SE Campbell; Margaret B Penno; Douglas W Ball; Stephen B Baylin
Cell-substratum interactions mediate oncogene-induced phenotype of lung cancer cells.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1996;7(9):1149-56.
1996: Jean-Pierre J Issa; Stephen B Baylin; Steven A Belinsky
Methylation of the estrogen receptor CpG island in lung tumors is related to the specific type of carcinogen exposure.
Cancer research 1996;56(16):3655-8.
1996: Paula M Vertino; Ray-Whay Chiu Yen; J Gao; Stephen B Baylin
De novo methylation of CpG island sequences in human fibroblasts overexpressing DNA (cytosine-5-)-methyltransferase.
Molecular and cellular biology 1996;16(8):4555-65.
1996: Herbert Chen; Eleanor B Carson-Walter; Stephen B Baylin; Barry D Nelkin; Douglas W Ball
Differentiation of medullary thyroid cancer by C-Raf-1 silences expression of the neural transcription factor human achaete-scute homolog-1.
Surgery 1996;120(2):168-72; discussion 173.
1996: Ronald A Morton; J J Watkins; G Steven Bova; M M Wales; Stephen B Baylin; William B Isaacs
Hypermethylation of chromosome 17P locus D17S5 in human prostate tissue.
The Journal of urology 1996;156(2 Pt 1):512-6.
1996: S J Kuerbitz; Stephen B Baylin
Retention of unmethylated CpG island alleles in human diploid fibroblast x fibrosarcoma hybrids expressing high levels of DNA methyltransferase.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1996;7(6):847-53.
1996: Rena Lapidus; AT Ferguson; YVONNE OTTAVIANO; F F Parl; H S Smith; S A Weitzman; Stephen B Baylin; Jean-Pierre J Issa; Nancy E Davidson
Methylation of estrogen and progesterone receptor gene 5' CpG islands correlates with lack of estrogen and progesterone receptor gene expression in breast tumors.
Clinical cancer research : an official journal of the American Association for Cancer Research 1996;2(5):805-10.
1996: Steven A Belinsky; Kristen J Nikula; Stephen B Baylin; Jean-Pierre J Issa
Increased cytosine DNA-methyltransferase activity is target-cell-specific and an early event in lung cancer.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(9):4045-50.
1996: Jean-Pierre J Issa; B A Zehnbauer; Curt I Civin; Michael I Collector; Saul J Sharkis; Nancy E Davidson; Scott H Kaufmann; Stephen B Baylin
The estrogen receptor CpG island is methylated in most hematopoietic neoplasms.
Cancer research 1996;56(5):973-77.
1996: Jean-Pierre J Issa; Stephen B Baylin
Epigenetics and human disease.
Nature medicine 1996;2(3):281-2.
1996: James G Herman; Jin Jen; A Merlo; Stephen B Baylin
Hypermethylation-associated inactivation indicates a tumor suppressor role for p15INK4B.
Cancer research 1996;56(4):722-7.
1996: J Wu; James G Herman; G Wilson; R Y Lee; Ray-Whay Chiu Yen; M Mabry; A de Bustros; Barry D Nelkin; Stephen B Baylin
Expression of prokaryotic HhaI DNA methyltransferase is transforming and lethal to NIH 3T3 cells.
Cancer research 1996;56(3):616-22.
1995: Steven A Belinsky; Kristen J Nikula; Stephen B Baylin; Jean-Pierre J Issa
A microassay for measuring cytosine DNA methyltransferase activity during tumor progression.
Toxicology letters 1995;82-83():335-40.
1995: Jeremy R Graff; James G Herman; Rena Lapidus; H Chopra; R Xu; David F Jarrard; William B Isaacs; PAULA PITHA-ROWE; Nancy E Davidson; Stephen B Baylin
E-cadherin expression is silenced by DNA hypermethylation in human breast and prostate carcinomas.
Cancer research 1995;55(22):5195-9.
1995: James G Herman; A Merlo; Li Mao; Rena Lapidus; Jean-Pierre J Issa; Nancy E Davidson; David Sidransky; Stephen B Baylin
Inactivation of the CDKN2/p16/MTS1 gene is frequently associated with aberrant DNA methylation in all common human cancers.
Cancer research 1995;55(20):4525-30.
1995: A Merlo; James G Herman; Li Mao; Daniel Lee; Edward Gabrielson; Peter C Burger; Stephen B Baylin; David Sidransky
5' CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers.
Nature medicine 1995;1(7):686-92.
1995: M M Wales; M A Biel; Wafik S El-Deiry; Barry D Nelkin; Jean-Pierre J Issa; W K Cavenee; S J Kuerbitz; Stephen B Baylin
p53 activates expression of HIC-1, a new candidate tumour suppressor gene on 17p13.3.
Nature medicine 1995;1(6):570-7.
1995: AT Ferguson; Rena Lapidus; Stephen B Baylin; Nancy E Davidson
Demethylation of the estrogen receptor gene in estrogen receptor-negative breast cancer cells can reactivate estrogen receptor gene expression.
Cancer research 1995;55(11):2279-83.
1995: E B Carson; M McMahon; Stephen B Baylin; Barry D Nelkin
Ret gene silencing is associated with Raf-1-induced medullary thyroid carcinoma cell differentiation.
Cancer research 1995;55(10):2048-52.
1994: Paula M Vertino; Jean-Pierre J Issa; Olivia M Pereira-Smith; Stephen B Baylin
Stabilization of DNA methyltransferase levels and CpG island hypermethylation precede SV40-induced immortalization of human fibroblasts.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1994;5(12):1395-402.
1994: J E Blaugrund; Michael M Johns; Yolanda Eby; Douglas W Ball; Stephen B Baylin; Ralph Hruban; David Sidransky
RET proto-oncogene mutations in inherited and sporadic medullary thyroid cancer.
Human molecular genetics 1994;3(10):1895-7.
1994: Jean-Pierre J Issa; YVONNE OTTAVIANO; P Celano; Stanley R Hamilton; Nancy E Davidson; Stephen B Baylin
Methylation of the oestrogen receptor CpG island links ageing and neoplasia in human colon.
Nature genetics 1994;7(4):536-40.
1994: L M McGregor; Stephen B Baylin; Constance A Griffin; Anita L Hawkins; Barry D Nelkin
Molecular cloning of the cDNA for human TrkC (NTRK3), chromosomal assignment, and evidence for a splice variant.
Genomics 1994;22(2):267-72.
1994: YVONNE OTTAVIANO; Jean-Pierre J Issa; F F Parl; H S Smith; Stephen B Baylin; Nancy E Davidson
Methylation of the estrogen receptor gene CpG island marks loss of estrogen receptor expression in human breast cancer cells.
Cancer research 1994;54(10):2552-5.
1994: A Merlo; Edward Gabrielson; M Mabry; R Vollmer; Stephen B Baylin; David Sidransky
Homozygous deletion on chromosome 9p and loss of heterozygosity on 9q, 6p, and 6q in primary human small cell lung cancer.
Cancer research 1994;54(9):2322-6.
1994: A Merlo; M Mabry; Edward Gabrielson; R Vollmer; Stephen B Baylin; David Sidransky
Frequent microsatellite instability in primary small cell lung cancer.
Cancer research 1994;54(8):2098-101.
1994: Barry D Nelkin; Douglas W Ball; Stephen B Baylin
Molecular abnormalities in tumors associated with multiple endocrine neoplasia type 2.
Endocrinology and metabolism clinics of North America 1994;23(1):187-213.
1994: Margaret B Penno; Thomas J August; Stephen B Baylin; M Mabry; R I Linnoila; V S Lee; D Croteau; X L Yang; C Rosada
Expression of CD44 in human lung tumors.
Cancer research 1994;54(5):1381-7.
1994: L T Wu; S D Averbuch; Douglas W Ball; A de Bustros; Stephen B Baylin; W P McGuire
Treatment of advanced medullary thyroid carcinoma with a combination of cyclophosphamide, vincristine, and dacarbazine.
Cancer 1994;73(2):432-6.
1993: Robert Udelsman; Douglas W Ball; Stephen B Baylin; C Y Wong; FA Osterman; SAMUEL SOSTRE
Preoperative localization of occult medullary carcinoma of the thyroid gland with single-photon emission tomography dimercaptosuccinic acid.
Surgery 1993;114(6):1083-9.
1993: J Wu; Jean-Pierre J Issa; James G Herman; D E Bassett; Barry D Nelkin; Stephen B Baylin
Expression of an exogenous eukaryotic DNA methyltransferase gene induces transformation of NIH 3T3 cells.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(19):8891-5.
1993: Jean-Pierre J Issa; Paula M Vertino; J Wu; Sunil Sazawal; P Celano; Barry D Nelkin; S R Hamilton; Stephen B Baylin
Increased cytosine DNA-methyltransferase activity during colon cancer progression.
Journal of the National Cancer Institute 1993;85(15):1235-40.
1993: Barry D Nelkin; Stephen B Baylin
Ret oncogene responsible for MEN2A.
Current biology : CB 1993;3(7):477-80.
1993: M Makos; Barry D Nelkin; Robert E Reiter; JR Gnarra; J Brooks; William B Isaacs; M Linehan; Stephen B Baylin
Regional DNA hypermethylation at D17S5 precedes 17p structural changes in the progression of renal tumors.
Cancer research 1993;53(12):2719-22.
1993: Douglas W Ball; Christopher G Azzoli; Stephen B Baylin; D Chi; S Dou; H Donis-Keller; A Cumaraswamy; M Borges; Barry D Nelkin
Identification of a human achaete-scute homolog highly expressed in neuroendocrine tumors.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(12):5648-52.
1993: M Makos; Barry D Nelkin; V R Chazin; W K Cavenee; G M Brodeur; Stephen B Baylin
DNA hypermethylation is associated with 17p allelic loss in neural tumors.
Cancer research 1993;53(12):2715-8.
1993: Terry Lairmore; Douglas W Ball; Stephen B Baylin; Samuel A Wells
Management of pheochromocytomas in patients with multiple endocrine neoplasia type 2 syndromes.
Annals of surgery 1993;217(6):595-601; discussion 601-3.
1993: Paula M Vertino; E A Spillare; C C Harris; Stephen B Baylin
Altered chromosomal methylation patterns accompany oncogene-induced transformation of human bronchial epithelial cells.
Cancer research 1993;53(7):1684-9.
1993: Stephen B Baylin; A C de Bustros; Douglas W Ball; Barry D Nelkin
Pathobiology of the C-cells.
Monographs in pathology 1993;(35):63-71.
1992: T Fukuhara; W C Hooper; Stephen B Baylin; J Benson; Jim Pruckler; A C Olson; B L Evatt; W R Vogler
Use of the polymerase chain reaction to detect hypermethylation in the calcitonin gene. A new, sensitive approach to monitor tumor cells in acute myelogenous leukemia.
Leukemia research 1992;16(10):1031-40.
1992: P Celano; C M Berchtold; D L Kizer; A Weeraratna; Barry D Nelkin; Stephen B Baylin; Robert A Casero
Characterization of an endogenous RNA transcript with homology to the antisense strand of the human c-myc gene.
The Journal of biological chemistry 1992;267(21):15092-6.
1992: Ray-Whay Chiu Yen; Paula M Vertino; Barry D Nelkin; J J Yu; Wafik S El-Deiry; A Cumaraswamy; G G Lennon; Barbara J Trask; P Celano; Stephen B Baylin
Isolation and characterization of the cDNA encoding human DNA methyltransferase.
Nucleic acids research 1992;20(9):2287-91.
1992: M Mabry; T W Moody; Stephen B Baylin
Preclinical research in early lung cancer: breakout group report.
Cancer research 1992;52(9 Suppl):2764s-2765s.
1992: Stephen B Baylin
Abnormal regional hypermethylation in cancer cells.
AIDS research and human retroviruses 1992;8(5):811-20.
1992: M Makos; Barry D Nelkin; M I Lerman; F Latif; B Zbar; Stephen B Baylin
Distinct hypermethylation patterns occur at altered chromosome loci in human lung and colon cancer.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(5):1929-33.
1992: Jeffrey F Moley; M B Brother; C T Fong; P S White; Stephen B Baylin; Barry D Nelkin; Samuel A Wells; Garrett M Brodeur
Consistent association of 1p loss of heterozygosity with pheochromocytomas from patients with multiple endocrine neoplasia type 2 syndromes.
Cancer research 1992;52(4):770-4.
1992: Douglas W Ball; D Compton; Barry D Nelkin; Stephen B Baylin; A de Bustros
Human calcitonin gene regulation by helix-loop-helix recognition sequences.
Nucleic acids research 1992;20(1):117-23.
1991: L F Barr; M Mabry; Barry D Nelkin; G Tyler; W S May; Stephen B Baylin
c-myc gene-induced alterations in protein kinase C expression: a possible mechanism facilitating myc-ras gene complementation.
Cancer research 1991;51(20):5514-9.
1991: Stephen B Baylin; M Makos; J J Wu; Ray-Whay Chiu Yen; A de Bustros; Paula M Vertino; Barry D Nelkin
Abnormal patterns of DNA methylation in human neoplasia: potential consequences for tumor progression.
Cancer cells (Cold Spring Harbor, N.Y. : 1989) 1991;3(10):383-90.
1991: Barry D Nelkin; D Przepiorka; PJ Burke; E D Thomas; Stephen B Baylin
Abnormal methylation of the calcitonin gene marks progression of chronic myelogenous leukemia.
Blood 1991;77(11):2431-4.
1991: Wafik S El-Deiry; Barry D Nelkin; P Celano; Ray-Whay Chiu Yen; J P Falco; S R Hamilton; Stephen B Baylin
High expression of the DNA methyltransferase gene characterizes human neoplastic cells and progression stages of colon cancer.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(8):3470-4.
1991: M Mabry; Barry D Nelkin; J P Falco; L F Barr; Stephen B Baylin
Transitions between lung cancer phenotypes--implications for tumor progression.
Cancer cells (Cold Spring Harbor, N.Y. : 1989) 1991;3(2):53-8.
1990: Barry D Nelkin; M Borges; M Mabry; Stephen B Baylin
Transcription factor levels in medullary thyroid carcinoma cells differentiated by Harvey ras oncogene: c-jun is increased.
Biochemical and biophysical research communications 1990;170(1):140-6.
1990: J P Falco; Stephen B Baylin; R Lupu; M Borges; Barry D Nelkin; R K Jasti; Nancy E Davidson; M Mabry
v-rasH induces non-small cell phenotype, with associated growth factors and receptors, in a small cell lung cancer cell line.
The Journal of clinical investigation 1990;85(6):1740-5.
1990: H Brauch; Farida Latif; Stephen B Baylin; Barry D Nelkin; S Hosoe; L Daniel; Gladys Glenn; I Danko; W E Bradley; M L Orcutt
MspI and DraI polymorphisms at the ERBA beta locus on chromosome 3p.
Nucleic acids research 1990;18(9):2833.
1990: A de Bustros; R Y Lee; D Compton; T Y Tsong; Stephen B Baylin; Barry D Nelkin
Differential utilization of calcitonin gene regulatory DNA sequences in cultured lines of medullary thyroid carcinoma and small-cell lung carcinoma.
Molecular and cellular biology 1990;10(4):1773-8.
1990: Stephen B Baylin
"APUD" cells: fact and fiction.
Trends in endocrinology and metabolism: TEM 1990;1(4):198-204.
1989: Barry D Nelkin; K Y Chen; A de Bustros; Bernard A Roos; Stephen B Baylin
Changes in calcitonin gene RNA processing during growth of a human medullary thyroid carcinoma cell line.
Cancer research 1989;49(24 Pt 1):6949-52.
1989: J M Nigro; S J Baker; A C Preisinger; J M Jessup; R Hostetter; K Cleary; S H Bigner; Nancy E Davidson; Stephen B Baylin; P Devilee
Mutations in the p53 gene occur in diverse human tumour types.
Nature 1989;342(6250):705-8.
1989: Stephen B Baylin
Neuroendocrine differentiation: a prognostic feature of non-small-cell lung cancer?
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1989;7(10):1375-6.
1989: Barry D Nelkin; Y Nakamura; R W White; A C de Bustros; James G Herman; S A Wells; Stephen B Baylin
Low incidence of loss of chromosome 10 in sporadic and hereditary human medullary thyroid carcinoma.
Cancer research 1989;49(15):4114-9.
1989: Ann L. Silverman; J G Park; Stanley R Hamilton; A F Gazdar; GD Luk; Stephen B Baylin
Abnormal methylation of the calcitonin gene in human colonic neoplasms.
Cancer research 1989;49(13):3468-73.
1989: M Mabry; T Nakagawa; Stephen B Baylin; O Pettengill; G Sorenson; Barry D Nelkin
Insertion of the v-Ha-ras oncogene induces differentiation of calcitonin-producing human small cell lung cancer.
The Journal of clinical investigation 1989;84(1):194-9.
1989: Barry D Nelkin; A C de Bustros; M Mabry; Stephen B Baylin
The molecular biology of medullary thyroid carcinoma. A model for cancer development and progression.
JAMA : the journal of the American Medical Association 1989;261(21):3130-5.
1989: FREDERICK HAUSHEER; S N Rao; Michael P Gamcsik; P A Kollman; O Michael Colvin; J D Saxe; Barry D Nelkin; I J McLennan; G Barnett; Stephen B Baylin
Computational analysis of structural and energetic consequences of DNA methylation.
Carcinogenesis 1989;10(6):1131-7.
1989: P Celano; Stephen B Baylin; Robert A Casero
Polyamines differentially modulate the transcription of growth-associated genes in human colon carcinoma cells.
The Journal of biological chemistry 1989;264(15):8922-7.
1989: Robert A Casero; S J Ervin; P Celano; Stephen B Baylin; R J Bergeron
Differential response to treatment with the bis(ethyl)polyamine analogues between human small cell lung carcinoma and undifferentiated large cell lung carcinoma in culture.
Cancer research 1989;49(3):639-43.
1988: M S Tockman; P K Gupta; J D Myers; J K Frost; Stephen B Baylin; E B Gold; A M Chase; P H Wilkinson; J L Mulshine
Sensitive and specific monoclonal antibody recognition of human lung cancer antigen on preserved sputum cells: a new approach to early lung cancer detection.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1988;6(11):1685-93.
1988: M Mabry; T Nakagawa; Barry D Nelkin; E McDowell; M Gesell; J C Eggleston; Robert A Casero; Stephen B Baylin
v-Ha-ras oncogene insertion: a model for tumor progression of human small cell lung cancer.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(17):6523-7.
1988: A de Bustros; Barry D Nelkin; Ann L. Silverman; G Ehrlich; Bernard J Poiesz; Stephen B Baylin
The short arm of chromosome 11 is a "hot spot" for hypermethylation in human neoplasia.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(15):5693-7.
1988: P Celano; Stephen B Baylin; Francis M Giardiello; Barry D Nelkin; Robert A Casero
Effect of polyamine depletion on c-myc expression in human colon carcinoma cells.
The Journal of biological chemistry 1988;263(12):5491-4.
1988: T Nakagawa; Barry D Nelkin; Stephen B Baylin; A de Bustros
Transcriptional and posttranscriptional modulation of calcitonin gene expression by sodium n-butyrate in cultured human medullary thyroid carcinoma.
Cancer research 1988;48(8):2096-100.
1987: Stephen B Baylin; Eric R Fearon; Bert Vogelstein; A de Bustros; Saul J Sharkis; P J Burke; S P Staal; Barry D Nelkin
Hypermethylation of the 5' region of the calcitonin gene is a property of human lymphoid and acute myeloid malignancies.
Blood 1987;70(2):412-7.
1987: T Nakagawa; M Mabry; A de Bustros; J N Ihle; Barry D Nelkin; Stephen B Baylin
Introduction of v-Ha-ras oncogene induces differentiation of cultured human medullary thyroid carcinoma cells.
Proceedings of the National Academy of Sciences of the United States of America 1987;84(16):5923-7.
1987: Robert A Casero; B Go; H W Theiss; J Smith; Stephen B Baylin; GD Luk
Cytotoxic response of the relatively difluoromethylornithine-resistant human lung tumor cell line NCI H157 to the polyamine analogue N1,N8-bis(ethyl)spermidine.
Cancer research 1987;47(15):3964-7.
1987: Lee Helman; Carol Jeanne Thiele; W M Linehan; Barry D Nelkin; Stephen B Baylin; Mark Israel
Molecular markers of neuroendocrine development and evidence of environmental regulation.
Proceedings of the National Academy of Sciences of the United States of America 1987;84(8):2336-9.
1987: K Tanaka; Stephen B Baylin; Barry D Nelkin; J R Testa
Cytogenetic studies of a human medullary thyroid carcinoma cell line.
Cancer genetics and cytogenetics 1987;25(1):27-35.
1987: Constance A Griffin; M Slavik; S C Chien; J Hermann; G Thompson; O Blanc; GD Luk; Stephen B Baylin; M D Abeloff
Phase I trial and pharmacokinetic study of intravenous and oral alpha-difluoromethylornithine.
Investigational new drugs 1987;5(2):177-86.
1986: A J Wong; J M Ruppert; J Eggleston; Stanley R Hamilton; Stephen B Baylin; Bert Vogelstein
Gene amplification of c-myc and N-myc in small cell carcinoma of the lung.
Science (New York, N.Y.) 1986;233(4762):461-4.
1986: M D Abeloff; S T Rosen; GD Luk; Stephen B Baylin; M Zeltzman; A Sjoerdsma
Phase II trials of alpha-difluoromethylornithine, an inhibitor of polyamine synthesis, in advanced small cell lung cancer and colon cancer.
Cancer treatment reports 1986;70(7):843-5.
1986: J M Ruppert; J C Eggleston; A deBustros; Stephen B Baylin
Disseminated calcitonin-poor medullary thyroid carcinoma in a patient with calcitonin-rich primary tumor.
The American journal of surgical pathology 1986;10(7):513-8.
1986: A deBustros; Stephen B Baylin; Michael A. Levine; Barry D Nelkin
Cyclic AMP and phorbol esters separately induce growth inhibition, calcitonin secretion, and calcitonin gene transcription in cultured human medullary thyroid carcinoma.
The Journal of biological chemistry 1986;261(17):8036-41.
1986: Stephen B Baylin; Jo W M Höppener; A de Bustros; Paul H Steenbergh; C J Lips; Barry D Nelkin
DNA methylation patterns of the calcitonin gene in human lung cancers and lymphomas.
Cancer research 1986;46(6):2917-22.
1986: J R Farndon; George S Leight; William G Dilley; Stephen B Baylin; R C Smallridge; T S Harrison; S A Wells
Familial medullary thyroid carcinoma without associated endocrinopathies: a distinct clinical entity.
The British journal of surgery 1986;73(4):278-81.
1986: GD Luk; M D Abeloff; P P McCann; A Sjoerdsma; Stephen B Baylin
Long-term maintenance therapy of established human small cell variant lung carcinoma implants in athymic mice with a cyclic regimen of difluoromethylornithine.
Cancer research 1986;46(4 Pt 1):1849-53.
1986: GD Luk; Stephen B Baylin
Anchorage dependency effects on difluoromethylornithine cytotoxicity in human lung carcinoma cells.
Cancer research 1986;46(4 Pt 1):1844-8.
1986: Robert A Casero; Stephen B Baylin; Barry D Nelkin; GD Luk
Human lung tumor sensitivity to difluoromethylornithine as related to ornithine decarboxylase messenger RNA levels.
Biochemical and biophysical research communications 1986;134(2):572-9.
1985: Gary S Wand; R L Ney; Stephen B Baylin; B Eipper; R E Mains
Characterization of a peptide alpha-amidation activity in human plasma and tissues.
Metabolism: clinical and experimental 1985;34(11):1044-52.
1985: A F Gazdar; P A Bunn; J D Minna; Stephen B Baylin
Origin of human small cell lung cancer.
Science (New York, N.Y.) 1985;229(4714):679-80.
1985: S A Wells; William G Dilley; J A Farndon; George S Leight; Stephen B Baylin
Early diagnosis and treatment of medullary thyroid carcinoma.
Archives of internal medicine 1985;145(7):1248-52.
1985: A Robinson-White; Stephen B Baylin; Thomas Olivecrona; M A Beaven
Binding of diamine oxidase activity to rat and guinea pig microvascular endothelial cells. Comparisons with lipoprotein lipase binding.
The Journal of clinical investigation 1985;76(1):93-100.
1985: P K Gupta; J D Myers; Stephen B Baylin; J L Mulshine; F Cuttitta; A F Gazdar
Improved antigen detection in ethanol-fixed cytologic specimens. A modified avidin-biotin-peroxidase complex (ABC) method.
Diagnostic cytopathology 1985;1(2):133-6.
1985: A de Bustros; Stephen B Baylin
Hormone production by tumours: biological and clinical aspects.
Clinics in endocrinology and metabolism 1985;14(1):221-56.
1985: A de Bustros; Stephen B Baylin; C L Berger; Bernard A Roos; S S Leong; Barry D Nelkin
Phorbol esters increase calcitonin gene transcription and decrease c-myc mRNA levels in cultured human medullary thyroid carcinoma.
The Journal of biological chemistry 1985;260(1):98-104.
1985: GD Luk; Stephen B Baylin
Polyamines in biology and medicine.
The Western journal of medicine 1985;142(1):88-90.
1985: Constance A Griffin; Stephen B Baylin
Oncogene expression in human small cell lung carcinoma.
Recent results in cancer research. Fortschritte der Krebsforschung. Progrès dans les recherches sur le cancer 1985;99():237-45.
1985: Jo W M Höppener; Paul H Steenbergh; J Zandberg; A H Geurts van Kessel; Stephen B Baylin; Barry D Nelkin; H S Jansz; Cornelis J M Lips
The second human calcitonin/CGRP gene is located on chromosome 11.
Human genetics 1985;70(3):259-63.
1985: Constance A Griffin; Stephen B Baylin
Expression of the c-myb oncogene in human small cell lung carcinoma.
Cancer research 1985;45(1):272-5.
1984: P Yang; Stephen B Baylin; GD Luk
Polyamines and intestinal growth: absolute requirement for ODC activity in adaptation during lactation.
The American journal of physiology 1984;247(5 Pt 1):G553-7.
1984: Barry D Nelkin; K I Rosenfeld; A de Bustros; S S Leong; Bernard A Roos; Stephen B Baylin
Structure and expression of a gene encoding human calcitonin and calcitonin gene related peptide.
Biochemical and biophysical research communications 1984;123(2):648-55.
1984: GD Luk; Stephen B Baylin
Inhibition of intestinal epithelial DNA synthesis and adaptive hyperplasia after jejunectomy in the rat by suppression of polyamine biosynthesis.
The Journal of clinical investigation 1984;74(3):698-704.
1984: G Mendelsohn; S A Wells; Stephen B Baylin
Relationship of tissue carcinoembryonic antigen and calcitonin to tumor virulence in medullary thyroid carcinoma. An immunohistochemical study in early, localized, and virulent disseminated stages of disease.
Cancer 1984;54(4):657-62.
1984: C L Berger; A de Bustros; Bernard A Roos; S S Leong; G Mendelsohn; M S Gesell; Stephen B Baylin
Human medullary thyroid carcinoma in culture provides a model relating growth dynamics, endocrine cell differentiation, and tumor progression.
The Journal of clinical endocrinology and metabolism 1984;59(2):338-43.
1984: GD Luk; Stephen B Baylin
Ornithine decarboxylase as a biologic marker in familial colonic polyposis.
The New England journal of medicine 1984;311(2):80-3.
1984: D Przepiorka; Stephen B Baylin; O W McBride; J R Testa; A de Bustros; Barry D Nelkin
The human calcitonin gene is located on the short arm of chromosome 11.
Biochemical and biophysical research communications 1984;120(2):493-9.
1984: M D Abeloff; M Slavik; GD Luk; Constance A Griffin; J Hermann; O Blanc; A Sjoerdsma; Stephen B Baylin
Phase I trial and pharmacokinetic studies of alpha-difluoromethylornithine--an inhibitor of polyamine biosynthesis.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1984;2(2):124-30.
1984: G Mendelsohn; Stephen B Baylin
Ectopic hormone production--biological and clinical implications.
Progress in clinical and biological research 1984;142():291-316.
1983: R Maneckjee; Stephen B Baylin
Use of radiolabeled monofluoromethyl-Dopa to define the subunit structure of human L-Dopa decarboxylase.
Biochemistry 1983;22(26):6058-63.
1983: GD Luk; Stephen B Baylin
Polyamines and intestinal growth--increased polyamine biosynthesis after jejunectomy.
The American journal of physiology 1983;245(5 Pt 1):G656-60.
1983: GD Luk; M D Abeloff; Constance A Griffin; Stephen B Baylin
Successful treatment with DL-alpha-difluoromethylornithine in established human small cell variant lung carcinoma implants in athymic mice.
Cancer research 1983;43(9):4239-43.
1983: GD Luk; Saul J Sharkis; M D Abeloff; P P McCann; A Sjoerdsma; Stephen B Baylin
Polyamine biosynthesis is required for the maintenance of peripheral blood cell elements in the rat.
Proceedings of the National Academy of Sciences of the United States of America 1983;80(16):5090-3.
1983: Andrew P Feinberg; Bert Vogelstein; M J Droller; Stephen B Baylin; Barry D Nelkin
Mutation affecting the 12th amino acid of the c-Ha-ras oncogene product occurs infrequently in human cancer.
Science (New York, N.Y.) 1983;220(4602):1175-7.
1983: G Goodwin; J H Shaper; M D Abeloff; G Mendelsohn; Stephen B Baylin
Analysis of cell surface proteins delineates a differentiation pathway linking endocrine and nonendocrine human lung cancers.
Proceedings of the National Academy of Sciences of the United States of America 1983;80(12):3807-11.
1983: GD Luk; Theodore M Bayless; Stephen B Baylin
Plasma postheparin diamine oxidase. Sensitive provocative test for quantitating length of acute intestinal mucosal injury in the rat.
The Journal of clinical investigation 1983;71(5):1308-15.
1983: Bernard A Roos; M B Huber; R S Birnbaum; D C Aron; A W Lindall; K Lips; Stephen B Baylin
Medullary thyroid carcinomas secrete a noncalcitonin peptide corresponding to the carboxyl-terminal region of preprocalcitonin.
The Journal of clinical endocrinology and metabolism 1983;56(4):802-7.
1983: S D Bernal; Stephen B Baylin; J H Shaper; A F Gazdar; Lan Bo Chen
Cytoskeleton-associated proteins of human lung cancer cells.
Cancer research 1983;43(4):1798-808.
1983: S Bernal; R Thompson; F Gilbert; Stephen B Baylin
In vitro and in vivo growth characteristics of two different cell populations in an established line of human neuroblastoma.
Cancer research 1983;43(3):1256-60.
1983: Saul J Sharkis; GD Luk; Michael I Collector; P P McCann; Stephen B Baylin; L L Sensenbrenner
Regulation of hematopoiesis II: the role of polyamine inhibition on helper or suppressor influences of the thymus.
Blood 1983;61(3):604-7.
1983: H K Oie; A F Gazdar; J D Minna; G C Weir; Stephen B Baylin
Clonal analysis of insulin and somatostatin secretion and L-dopa decarboxylase expression by a rat islet cell tumor.
Endocrinology 1983;112(3):1070-5.
1983: J Francis; R Thompson; S D Bernal; GD Luk; Stephen B Baylin
Effects of dibutyryl cyclic adenosine 3':5'-monophosphate on the growth of cultured human small-cell lung carcinoma and the specific cellular activity of L-dopa decarboxylase.
Cancer research 1983;43(2):639-45.
1983: Stephen B Baylin; R H Jackson; W Lennarz; J H Shaper
The spectrum of human lung cancer cells in culture: a potential model for studying molecular determinants of tumor progression and metastasis.
Symposium on Fundamental Cancer Research 1983;36():281-91.
1982: Stephen B Baylin; G Mendelsohn
Time-dependent changes in human tumors: implications for diagnosis and clinical behavior.
Seminars in oncology 1982;9(4):504-12.
1982: S A Wells; Stephen B Baylin; I S Johnsrude; D P Harrington; G Mendelsohn; David A Ontjes; C W Cooper
Thyroid venous catheterization in the early diagnosis of familial medullary thyroid carcinoma.
Annals of surgery 1982;196(5):505-11.
1982: Stephen B Baylin; R D Jackson; G Goodwin; A F Gazdar
Neuroendocrine-related biochemistry in the spectrum of human lung cancers.
Experimental lung research 1982;3(3-4):209-23.
1982: GD Luk; G Goodwin; A F Gazdar; Stephen B Baylin
Growth-inhibitory effects of DL-alpha-difluoromethylornithine in the spectrum of human lung carcinoma cells in culture.
Cancer research 1982;42(8):3070-3.
1982: Stephen B Baylin; A F Gazdar; J D Minna; S D Bernal; J H Shaper
A unique cell-surface protein phenotype distinguishes human small-cell from non-small-cell lung cancer.
Proceedings of the National Academy of Sciences of the United States of America 1982;79(15):4650-4.
1982: S A Wells; Stephen B Baylin; George S Leight; J K Dale; William G Dilley; J R Farndon
The importance of early diagnosis in patients with hereditary medullary thyroid carcinoma.
Annals of surgery 1982;195(5):595-9.
1982: GD Luk; Curt I Civin; R M Weissman; Stephen B Baylin
Ornithine decarboxylase: essential in proliferation but not differentiation of human promyelocytic leukemia cells.
Science (New York, N.Y.) 1982;216(4541):75-7.
1982: G Goodwin; Stephen B Baylin
Relationships between neuroendocrine differentiation and sensitivity to gamma-radiation in culture line OH-1 of human small cell lung carcinoma.
Cancer research 1982;42(4):1361-7.
1982: S M Lippman; G Mendelsohn; D L Trump; S A Wells; Stephen B Baylin
The prognostic and biological significance of cellular heterogeneity in medullary thyroid carcinoma: a study of calcitonin, L-dopa decarboxylase, and histaminase.
The Journal of clinical endocrinology and metabolism 1982;54(2):233-40.
1981: M D Abeloff; D L Trump; Stephen B Baylin
Ectopic adrenocorticotrophic (ACTH) syndrome and small cell carcinoma of the lung-assessment of clinical implications in patients on combination chemotherapy.
Cancer 1981;48(5):1082-7.
1981: Stephen B Baylin; K C Wieman; J A O'Neil; Bernard A Roos
Multiple forms of human tumor calcitonin demonstrated by denaturing polyacrylamide gel electrophoresis and lectin affinity chromatography.
The Journal of clinical endocrinology and metabolism 1981;53(3):489-97.
1981: C L Berger; G Goodwin; G Mendelsohn; J C Eggleston; M D Abeloff; Seena Aisner; Stephen B Baylin
Endocrine-related biochemistry in the spectrum of human lung carcinoma.
The Journal of clinical endocrinology and metabolism 1981;53(2):422-9.
1981: Stephen B Baylin; S A Wells
Management of hereditary medullary thyroid carcinoma.
Clinics in endocrinology and metabolism 1981;10(2):367-78.
1981: S H Bigner; E B Cox; G Mendelsohn; Stephen B Baylin; S A Wells; J C Eggleston
Medullary carcinoma of the thyroid in the multiple endocrine neoplasia IIA syndrome.
The American journal of surgical pathology 1981;5(5):459-72.
1981: A F Gazdar; M H Zweig; D N Carney; A C Van Steirteghen; Stephen B Baylin; J D Minna
Levels of creatine kinase and its BB isoenzyme in lung cancer specimens and cultures.
Cancer research 1981;41(7):2773-7.
1981: GD Luk; W P Vaughan; P J Burke; Stephen B Baylin
Diamine oxidase as a plasma marker of rat intestinal mucosal injury and regeneration after administration of 1-beta-D-arabinofuranosylcytosine.
Cancer research 1981;41(6):2334-7.
1981: GD Luk; G Goodwin; L J Marton; Stephen B Baylin
Polyamines are necessary for the survival of human small-cell lung carcinoma in culture.
Proceedings of the National Academy of Sciences of the United States of America 1981;78(4):2355-8.
1980: G D Lux; L J Marton; Stephen B Baylin
Ornithine decarboxylase is important in intestinal mucosal maturation and recovery from injury in rats.
Science (New York, N.Y.) 1980;210(4466):195-8.
1980: A F Gazdar; D N Carney; E K Russell; H L Sims; Stephen B Baylin; P A Bunn; J G Guccion; J D Minna
Establishment of continuous, clonable cultures of small-cell carcinoma of lung which have amine precursor uptake and decarboxylation cell properties.
Cancer research 1980;40(10):3502-7.
1980: G Mendelsohn; Stephen B Baylin; S H Bigner; S A Wells; J C Eggleston
Anaplastic variants of medullary thyroid carcinoma: a light-microscopic and immunohistochemical study.
The American journal of surgical pathology 1980;4(4):333-41.
1980: Stephen B Baylin; Beryl J Rosenstein; L J Marton; D H Lockwood
Age-related abnormalities of circulating polyamines and diamine oxidase activity in cystic fibrosis heterozygotes and homozygotes.
Pediatric research 1980;14(8):921-5.
1980: GD Luk; Theodore M Bayless; Stephen B Baylin
Diamine oxidase (histaminase). A circulating marker for rat intestinal mucosal maturation and integrity.
The Journal of clinical investigation 1980;66(1):66-70.
1980: Stephen B Baylin; M D Abeloff; G Goodwin; D N Carney; A F Gazdar
Activities of L-dopa decarboxylase and diamine oxidase (histaminase) in human lung cancers and decarboxylase as a marker for small (oat) cell cancer in cell culture.
Cancer research 1980;40(6):1990-4.
1980: David S Ettinger; N B Rosenshein; T H Parmley; G Mendelsohn; Stephen B Baylin
Tumor cell origin of histaminase activity in ascites fluid from patients with ovarian carcinoma.
Cancer 1980;45(10):2568-72.
1980: Bernard A Roos; A W Lindall; Stephen B Baylin; J A O'Neil; A L Frelinger; R S Birnbaum; P W Lambert
Plasma immunoreactive calcitonin in lung cancer.
The Journal of clinical endocrinology and metabolism 1980;50(4):659-66.
1980: G Mendelsohn; Stephen B Baylin; J C Eggleston
Relationship of metastatic medullary thyroid carcinoma to calcitonin content of pheochromocytomas: an immunohistochemical study.
Cancer 1980;45(3):498-502.
1980: Stephen B Baylin; G Mendelsohn
Ectopic (inappropriate) hormone production by tumors: mechanisms involved and the biological and clinical implications.
Endocrine reviews 1980;1(1):45-77.
1979: Stephen B Baylin; G Mendelsohn; W R Weisburger; Donald S Gann; J C Eggleston
Levels of histaminase and L-DOPA decarboxylase activity in the transition from C-cell hyperplasia to familial medullary thyroid carcinoma.
Cancer 1979;44(4):1315-21.
1979: D L Trump; G Mendelsohn; Stephen B Baylin
Discordance between plasma calcitonin and tumor-cell mass in medullary thyroid carcinoma.
The New England journal of medicine 1979;301(5):253-5.
1979: G Mendelsohn; J C Eggleston; J L Olson; S I Said; Stephen B Baylin
Vasoactive intestinal peptide and its relationship to ganglion cell differentiation in neuroblastic tumors.
Laboratory investigation; a journal of technical methods and pathology 1979;41(2):144-9.
1979: G Mendelsohn; R D'Agostino; J C Eggleston; Stephen B Baylin
Distribution of beta-endorphin immunoreactivity in normal human pituitary.
The Journal of clinical investigation 1979;63(6):1297-301.
1979: D F Hutcheon; Theodore M Bayless; John L Cameron; Stephen B Baylin
Hormone-mediated watery diarrhea in a family with multiple endocrine neoplasms.
Annals of internal medicine 1979;90(6):932-4.
1979: M D Abeloff; J C Eggleston; G Mendelsohn; David S Ettinger; Stephen B Baylin
Changes in morphologic and biochemical characteristics of small cell carcinoma of the lung. A clinicopathologic study.
The American journal of medicine 1979;66(5):757-64.
1979: Stephen B Baylin; TAH-HSIUNG HSU; S A Stevens; C H Kallman; D L Trump; M A Beaven
The effects of L-dopa on in vitro and in vivo calcitonin release from medullary thyroid carcinoma.
The Journal of clinical endocrinology and metabolism 1979;48(3):408-14.
1979: C E Cox; J VanVickle; L C Froome; G Mendelsohn; Stephen B Baylin; S A Wells
Carcinoembryonic antigen and calcitonin as markers of malignancy in medullary thyroid carcinoma.
Surgical forum 1979;30():120-1.
1979: Bernard A Roos; A W Lindall; Stephen B Baylin; J O'Neil; A L Frelinger; R S Birnbaum; P W Lambert
Plasma immunoreactive calcitonin in lung cancer.
Endocrine research communications 1979;6(2):169-90.
1978: S A Wells; Stephen B Baylin; Donald S Gann; R E Farrell; W G Dilley; S H Preissig; W M Linehan; C W Cooper
Medullary thyroid carcinoma: relationship of method of diagnosis to pathologic staging.
Annals of surgery 1978;188(3):377-83.
1978: S A Wells; Stephen B Baylin; W M Linehan; R E Farrell; E B Cox; C W Cooper
Provocative agents and the diagnosis of medullary carcinoma of the thyroid gland.
Annals of surgery 1978;188(2):139-41.
1978: Stephen B Baylin; W R Weisburger; J C Eggleston; G Mendelsohn; M A Beaven; M D Abeloff; David S Ettinger
Variable content of histaminase, L-dopa decarboxylase and calcitonin in small-cell carcinoma of the lung. Biologic and clinical implications.
The New England journal of medicine 1978;299(3):105-10.
1978: Stephen B Baylin; S A Stevens; K M Shakir
Association of diamine oxidase and ornithine decarboxylase with maturing cells in rapidly proliferating epithelium.
Biochimica et biophysica acta 1978;541(3):415-9.
1978: G Mendelsohn; J C Eggleston; W R Weisburger; Donald S Gann; Stephen B Baylin
Calcitonin and histaminase in C-cell hyperplasia and medullary thyroid carcinoma. A light microscopic and immunohistochemical study.
The American journal of pathology 1978;92(1):35-52.
1978: David S Ettinger; Stephen B Baylin; D Minaberry; M D Abeloff; E D Mellits
Response of plasma histaminase activity to heparin in normal subjects and in patients with small cell carcinoma of the lung.
Journal of the National Cancer Institute 1978;60(6):1239-42.
1978: W R Weisburger; G Mendelsohn; J C Eggleston; Stephen B Baylin
Immunohistochemical localization of histaminase (diamine oxidase) in decidual cells of human placenta.
Laboratory investigation; a journal of technical methods and pathology 1978;38(6):703-6.
1978: Stephen B Baylin
The multiple endocrine neoplasia syndromes: implications for the study of inherited tumors.
Seminars in oncology 1978;5(1):35-45.
1978: Stephen B Baylin; S H Hsu; Donald S Gann; R C Smallridge; S A Wells
Inherited medullary thyroid carcinoma: a final monoclonal mutation in one of multiple clones of susceptible cells.
Science (New York, N.Y.) 1978;199(4327):429-31.
1977: K M Shakir; Simeon Margolis; Stephen B Baylin
Localization of histamine (diamine oxidase) in rat small intestinal mucosa: site of release by heparin.
Biochemical pharmacology 1977;26(24):2343-7.
1977: Stephen B Baylin; A L Bailey; TAH-HSIUNG HSU; G V Foster
Degradation of human calcitonin in human plasmas.
Metabolism: clinical and experimental 1977;26(12):1345-54.
1977: D L Trump; J N Livingston; Stephen B Baylin
Watery diarrhea syndrome in an adult with ganglioneuroma-pheochromocytoma: identification of vasoactive intestinal peptide, calcitonin, and catecholamines and assessment of their biologic activity.
Cancer 1977;40(4):1526-32.
1977: Peter O Kwiterovich; J R Farah; W Virgil Brown; P S Bachorik; Stephen B Baylin; C A Neill
The clinical, biochemical, and familial presentation of type V hyperlipoproteinemia in childhood.
Pediatrics 1977;59(4):513-25.
1977: Stephen B Baylin
Histaminase (diamine oxidase) activity in human tumors: an expression of a mature genome.
Proceedings of the National Academy of Sciences of the United States of America 1977;74(3):883-7.
1976: M D Abeloff; David S Ettinger; Stephen B Baylin; T Hazra
Management of small cell carcinoma of the lung: therapy, staging, and biochemical markers.
Cancer 1976;38(3):1394-401.
1976: Stephen B Baylin; Donald S Gann; S H Hsu
Clonal origin of inherited medullary thyroid carcinoma and pheochromocytoma.
Science (New York, N.Y.) 1976;193(4250):321-3.
1975: Stephen B Baylin; M D Abeloff; K C Wieman; J W Tomford; David S Ettinger
Elevated histaminase (diamine oxidase) activity in small-cell carcinoma of the lung.
The New England journal of medicine 1975;293(25):1286-90.
1975: M A Beaven; J R Marshall; Stephen B Baylin; A Sjoerdsma
Changes in plasma histaminase activity during normal early human pregnancy and pregnancy disorders.
American journal of obstetrics and gynecology 1975;123(6):605-9.
1975: Stephen B Baylin; Simeon Margolis
Purification of histaminase (diamine oxidase) from human pregnancy plasma by affinity chromatography.
Biochimica et biophysica acta 1975;397(2):294-306.
1975: Stephen B Baylin; Z Horakova; M A Beaven
Increase in food consumption and growth after treatment with aminoguanidine.
Experientia 1975;31(5):562-4.
1974: Stephen B Baylin
Medullary carcinoma of the thyroid gland: use of biochemical parameters in detection and surgical management of the tumor.
The Surgical clinics of North America 1974;54(2):309-23.
1973: E B Knights; Stephen B Baylin; G V Foster
Control of polypeptide hormones by enzymatic degradation.
Lancet 1973;2(7831):719-23.
1973: Stephen B Baylin; M A Beaven; R M Krauss; H R Keiser
Response of plasma histaminase activity to small doses of heparin in normal subjects and patients with hyperlipoproteinemia.
The Journal of clinical investigation 1973;52(8):1985-93.
1972: Stephen B Baylin; M A Beaven; L M Buja; H R Keiser
Histaminase activity: a biochemical marker for medullary carcinoma of the thyroid.
The American journal of medicine 1972;53(6):723-33.
1972: Stephen B Baylin; M A Beaven; H R Keiser; A H Tashjian; K E Melvin
Serum histaminase and calcitonin levels in medullary carcinoma of the thyroid.
Lancet 1972;1(7748):455-8.
1970: Stephen B Baylin; M A Beaven; K Engelman; A Sjoerdsma
Elevated histaminase activity in medullary carcinoma of the thyroid gland.
The New England journal of medicine 1970;283(23):1239-44.
1966: G J Baylin; W J DeMaria; Stephen B Baylin; R P Krueger; A P Sanders
ATP concentration and localization of sites of epinephrine induced renal artery constriction.
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.) 1966;122(2):396-9.